{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0AFU8","secondaryAccessions":["P29015"],"uniProtkbId":"RISA_ECOLI","entryAudit":{"firstPublicDate":"2005-12-20","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2005-12-20","entryVersion":143,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Riboflavin synthase"},"shortNames":[{"value":"RS"}],"ecNumbers":[{"value":"2.5.1.9"}]}},"genes":[{"geneName":{"value":"ribC"},"synonyms":[{"value":"ribE"}],"orderedLocusNames":[{"value":"b1662"},{"value":"JW1654"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9022701"}],"value":"Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20772"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15934"},{"database":"ChEBI","id":"CHEBI:57986"},{"database":"ChEBI","id":"CHEBI:58201"}],"ecNumber":"2.5.1.9","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9022701"}]}},{"texts":[{"value":"Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11399071"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12927541"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9022701"}],"value":"Homotrimer. Unlike in B.subtilis, does not interact with 6,7-dimethyl-8-ribityllumazine synthase"}],"commentType":"SUBUNIT"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Riboflavin synthase","featureId":"PRO_0000068166"},{"type":"Repeat","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Lumazine-binding 1"},{"type":"Repeat","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Lumazine-binding 2"},{"type":"Binding site","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16489"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2YN92"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12927541"}],"ligand":{"name":"2,4-dihydroxypteridine","id":"ChEBI:CHEBI:16489","label":"1"}},{"type":"Binding site","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16489"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2YN92"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12927541"}],"ligand":{"name":"2,4-dihydroxypteridine","id":"ChEBI:CHEBI:16489","label":"2","note":"ligand shared between two trimeric partners"}},{"type":"Binding site","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16489"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2YN92"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12927541"}],"ligand":{"name":"2,4-dihydroxypteridine","id":"ChEBI:CHEBI:16489","label":"2","note":"ligand shared between two trimeric partners"}},{"type":"Binding site","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16489"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2YN92"}],"ligand":{"name":"2,4-dihydroxypteridine","id":"ChEBI:CHEBI:16489","label":"2","note":"ligand shared between two trimeric partners"}},{"type":"Binding site","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in other chain","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16489"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2YN92"}],"ligand":{"name":"2,4-dihydroxypteridine","id":"ChEBI:CHEBI:16489","label":"2","note":"ligand shared between two trimeric partners"}},{"type":"Binding site","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16489"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2YN92"}],"ligand":{"name":"2,4-dihydroxypteridine","id":"ChEBI:CHEBI:16489","label":"1"}},{"type":"Binding site","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16489"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2YN92"}],"ligand":{"name":"2,4-dihydroxypteridine","id":"ChEBI:CHEBI:16489","label":"1"}},{"type":"Beta strand","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Helix","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Turn","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Helix","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Helix","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Helix","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Helix","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Helix","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Beta strand","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]},{"type":"Helix","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1I8D"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0686","category":"Biological process","name":"Riboflavin biosynthesis"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"9022701","citationType":"journal article","authors":["Eberhardt S.M.R.","Richter G.","Gimbel W.","Werner T.","Bacher A."],"citationCrossReferences":[{"database":"PubMed","id":"9022701"},{"database":"DOI","id":"10.1111/j.1432-1033.1996.0712r.x"}],"title":"Cloning, sequencing, mapping and hyperexpression of the ribC gene coding for riboflavin synthase of Escherichia coli.","publicationDate":"1996","journal":"Eur. J. Biochem.","firstPage":"712","lastPage":"719","volume":"242"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","FUNCTION","CATALYTIC ACTIVITY","SUBUNIT"],"referenceComments":[{"value":"K12 / RR28","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9023191","citationType":"journal article","authors":["Hensel M.","Shea J.E.","Baeumler A.J.","Gleeson C.","Blattner F.R.","Holden D.W."],"citationCrossReferences":[{"database":"PubMed","id":"9023191"},{"database":"DOI","id":"10.1128/jb.179.4.1105-1111.1997"}],"title":"Analysis of the boundaries of Salmonella pathogenicity island 2 and the corresponding chromosomal region of Escherichia coli K-12.","publicationDate":"1997","journal":"J. Bacteriol.","firstPage":"1105","lastPage":"1111","volume":"179"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"9097039","citationType":"journal article","authors":["Aiba H.","Baba T.","Fujita K.","Hayashi K.","Inada T.","Isono K.","Itoh T.","Kasai H.","Kashimoto K.","Kimura S.","Kitakawa M.","Kitagawa M.","Makino K.","Miki T.","Mizobuchi K.","Mori H.","Mori T.","Motomura K.","Nakade S.","Nakamura Y.","Nashimoto H.","Nishio Y.","Oshima T.","Saito N.","Sampei G.","Seki Y.","Sivasundaram S.","Tagami H.","Takeda J.","Takemoto K.","Takeuchi Y.","Wada C.","Yamamoto Y.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"9097039"},{"database":"DOI","id":"10.1093/dnares/3.6.363"}],"title":"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.","publicationDate":"1996","journal":"DNA Res.","firstPage":"363","lastPage":"377","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"11399071","citationType":"journal article","authors":["Truffault V.","Coles M.","Diercks T.","Abelmann K.","Eberhardt S.","Luttgen H.","Bacher A.","Kessler H."],"citationCrossReferences":[{"database":"PubMed","id":"11399071"},{"database":"DOI","id":"10.1006/jmbi.2001.4683"}],"title":"The solution structure of the N-terminal domain of riboflavin synthase.","publicationDate":"2001","journal":"J. Mol. Biol.","firstPage":"949","lastPage":"960","volume":"309"},"referencePositions":["STRUCTURE BY NMR OF 1-97 IN COMPLEX WITH RIBOFLAVIN"]},{"referenceNumber":7,"citation":{"id":"11377200","citationType":"journal article","authors":["Liao D.I.","Wawrzak Z.","Calabrese J.C.","Viitanen P.V.","Jordan D.B."],"citationCrossReferences":[{"database":"PubMed","id":"11377200"},{"database":"DOI","id":"10.1016/s0969-2126(01)00600-1"}],"title":"Crystal structure of riboflavin synthase.","publicationDate":"2001","journal":"Structure","firstPage":"399","lastPage":"408","volume":"9"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)"]},{"referenceNumber":8,"citation":{"id":"12927541","citationType":"journal article","authors":["Meining W.","Eberhardt S.","Bacher A.","Ladenstein R."],"citationCrossReferences":[{"database":"PubMed","id":"12927541"},{"database":"DOI","id":"10.1016/s0022-2836(03)00844-1"}],"title":"The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution.","publicationDate":"2003","journal":"J. Mol. Biol.","firstPage":"1053","lastPage":"1063","volume":"331"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 1-97 IN COMPLEX WITH RIBOFLAVIN"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X69109","properties":[{"key":"ProteinId","value":"CAA48861.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U68703","properties":[{"key":"ProteinId","value":"AAB47940.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC74734.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAA15429.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S28526","properties":[{"key":"EntryName","value":"S28526"}]},{"database":"RefSeq","id":"NP_416179.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000493947.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"PDB","id":"1HZE","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=1-97"}]},{"database":"PDB","id":"1I18","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=1-97"}]},{"database":"PDB","id":"1I8D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C=1-213"}]},{"database":"PDB","id":"1PKV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B=1-97"}]},{"database":"PDBsum","id":"1HZE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1I18","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1I8D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1PKV","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P0AFU8","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P0AFU8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0AFU8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4261654","properties":[{"key":"Interactions","value":"52"}]},{"database":"DIP","id":"DIP-47865N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P0AFU8","properties":[{"key":"Number of interactors","value":"785"}]},{"database":"IntAct","id":"P0AFU8","properties":[{"key":"Interactions","value":"3"}]},{"database":"STRING","id":"511145.b1662","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB00140","properties":[{"key":"GenericName","value":"Riboflavin"}]},{"database":"jPOST","id":"P0AFU8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b1662","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC74734","properties":[{"key":"ProteinId","value":"AAC74734"},{"key":"GeneId","value":"b1662"}]},{"database":"GeneID","id":"93775817","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"945848","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW1654","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b1662","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_09535","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.595","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB1378","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG0307","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_034388_0_1_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P0AFU8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"IGGHAMS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9788537at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P0AFU8","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:RIBOFLAVIN-SYN-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:RIBOFLAVIN-SYN-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.5.1.9","properties":[{"key":"OrganismId","value":"2026"}]},{"database":"SABIO-RK","id":"P0AFU8","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00275","properties":[{"key":"RectionId","value":"UER00405"}]},{"database":"EvolutionaryTrace","id":"P0AFU8","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P0AFU8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18304323"}]},{"database":"GO","id":"GO:0004746","properties":[{"key":"GoTerm","value":"F:riboflavin synthase activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9022701"}]},{"database":"GO","id":"GO:0009231","properties":[{"key":"GoTerm","value":"P:riboflavin biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9022701"}]},{"database":"CDD","id":"cd00402","properties":[{"key":"EntryName","value":"Riboflavin_synthase_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.30.20:FF:000003","properties":[{"key":"EntryName","value":"Riboflavin synthase, alpha subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.30.20:FF:000005","properties":[{"key":"EntryName","value":"Riboflavin synthase, alpha subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.30.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR023366","properties":[{"key":"EntryName","value":"ATP_synth_asu-like_sf"}]},{"database":"InterPro","id":"IPR001783","properties":[{"key":"EntryName","value":"Lumazine-bd"}]},{"database":"InterPro","id":"IPR026017","properties":[{"key":"EntryName","value":"Lumazine-bd_dom"}]},{"database":"InterPro","id":"IPR017938","properties":[{"key":"EntryName","value":"Riboflavin_synthase-like_b-brl"}]},{"database":"NCBIfam","id":"NF006767","properties":[{"key":"EntryName","value":"PRK09289.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF009566","properties":[{"key":"EntryName","value":"PRK13020.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR00187","properties":[{"key":"EntryName","value":"ribE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21098:SF0","properties":[{"key":"EntryName","value":"RIBOFLAVIN SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21098","properties":[{"key":"EntryName","value":"RIBOFLAVIN SYNTHASE ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00677","properties":[{"key":"EntryName","value":"Lum_binding"},{"key":"MatchStatus","value":"2"}]},{"database":"PIRSF","id":"PIRSF000498","properties":[{"key":"EntryName","value":"Riboflavin_syn_A"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF63380","properties":[{"key":"EntryName","value":"Riboflavin synthase domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51177","properties":[{"key":"EntryName","value":"LUMAZINE_BIND"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MFTGIVQGTAKLVSIDEKPNFRTHVVELPDHMLDGLETGASVAHNGCCLTVTEINGNHVSFDLMKETLRITNLGDLKVGDWVNVERAAKFSDEIGGHLMSGHIMTTAEVAKILTSENNRQIWFKVQDSQLMKYILYKGFIGIDGISLTVGEVTPTRFCVHLIPETLERTTLGKKKLGARVNIEIDPQTQAVVDTVERVLAARENAMNQPGTEA","length":213,"molWeight":23445,"crc64":"CD1C7E40E4AC88B6","md5":"BA36EC06B78CD67AC2924910795C560C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBUNIT":1},"countByFeatureType":{"Chain":1,"Repeat":2,"Binding site":7,"Beta strand":12,"Helix":7,"Turn":1},"uniParcId":"UPI0000113130"}}