{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0AEC5","secondaryAccessions":["P26607","P77032"],"uniProtkbId":"BARA_ECOLI","entryAudit":{"firstPublicDate":"2005-12-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-12-06","entryVersion":153,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Signal transduction histidine-protein kinase BarA"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11022030"}],"value":"2.7.13.3"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1574005"}],"value":"barA"},"orderedLocusNames":[{"value":"b2786"},{"value":"JW2757"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11022030"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12193630"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12533459"}],"value":"Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system (PubMed:12193630, PubMed:12533459). Phosphorylates UvrY, probably via a four-step phosphorelay (PubMed:11022030)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.","ecNumber":"2.7.13.3","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11022030"}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P0AEC5","intActId":"EBI-546740"},"interactantTwo":{"uniProtKBAccession":"P0ABH9","geneName":"clpA","intActId":"EBI-546140"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15919996"}],"value":"Cell inner membrane","id":"SL-0037"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11022030"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1574005"},{"evidenceCode":"ECO:0000305"}],"value":"Autophosphorylated (PubMed:11022030, PubMed:1574005). Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain (Probable)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11022030"}],"value":"Inactivation of the gene leads to hydrogen peroxide hypersensitivity"}],"commentType":"DISRUPTION PHENOTYPE"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":918,"modifier":"EXACT"}},"description":"Signal transduction histidine-protein kinase BarA","featureId":"PRO_0000074697"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":918,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"HAMP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00102"}]},{"type":"Domain","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"Histidine kinase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00107"}]},{"type":"Domain","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":785,"modifier":"EXACT"}},"description":"Response regulatory","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00169"}]},{"type":"Domain","location":{"start":{"value":822,"modifier":"EXACT"},"end":{"value":918,"modifier":"EXACT"}},"description":"HPt","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00110"}]},{"type":"Modified residue","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Phosphohistidine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00107"}]},{"type":"Modified residue","location":{"start":{"value":718,"modifier":"EXACT"},"end":{"value":718,"modifier":"EXACT"}},"description":"4-aspartylphosphate","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00169"}]},{"type":"Modified residue","location":{"start":{"value":861,"modifier":"EXACT"},"end":{"value":861,"modifier":"EXACT"}},"description":"Phosphohistidine","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00110"}]}],"keywords":[{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0997","category":"Cellular component","name":"Cell inner membrane"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0902","category":"Biological process","name":"Two-component regulatory system"}],"references":[{"referenceNumber":1,"citation":{"id":"1574005","citationType":"journal article","authors":["Nagasawa S.","Tokishita S.","Aiba H.","Mizuno T."],"citationCrossReferences":[{"database":"PubMed","id":"1574005"},{"database":"DOI","id":"10.1111/j.1365-2958.1992.tb01530.x"}],"title":"A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli.","publicationDate":"1992","journal":"Mol. Microbiol.","firstPage":"799","lastPage":"807","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","AUTOPHOSPHORYLATION"],"referenceComments":[{"value":"K12","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"9205837","citationType":"journal article","authors":["Yamamoto Y.","Aiba H.","Baba T.","Hayashi K.","Inada T.","Isono K.","Itoh T.","Kimura S.","Kitagawa M.","Makino K.","Miki T.","Mitsuhashi N.","Mizobuchi K.","Mori H.","Nakade S.","Nakamura Y.","Nashimoto H.","Oshima T.","Oyama S.","Saito N.","Sampei G.","Satoh Y.","Sivasundaram S.","Tagami H.","Takahashi H.","Takeda J.","Takemoto K.","Uehara K.","Wada C.","Yamagata S.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"9205837"},{"database":"DOI","id":"10.1093/dnares/4.2.91"}],"title":"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.","publicationDate":"1997","journal":"DNA Res.","firstPage":"91","lastPage":"113","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 106-918"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"11022030","citationType":"journal article","authors":["Pernestig A.-K.","Melefors O.","Georgellis D."],"citationCrossReferences":[{"database":"PubMed","id":"11022030"},{"database":"DOI","id":"10.1074/jbc.m001550200"}],"title":"Identification of UvrY as the cognate response regulator for the BarA sensor kinase in Escherichia coli.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"225","lastPage":"231","volume":"276"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","AUTOPHOSPHORYLATION","DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"K12 / MC4100 / ATCC 35695 / DSM 6574","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"12193630","citationType":"journal article","authors":["Suzuki K.","Wang X.","Weilbacher T.","Pernestig A.-K.","Melefors O.","Georgellis D.","Babitzke P.","Romeo T."],"citationCrossReferences":[{"database":"PubMed","id":"12193630"},{"database":"DOI","id":"10.1128/jb.184.18.5130-5140.2002"}],"title":"Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.","publicationDate":"2002","journal":"J. Bacteriol.","firstPage":"5130","lastPage":"5140","volume":"184"},"referencePositions":["FUNCTION"],"referenceComments":[{"value":"K12 / MC4100 / ATCC 35695 / DSM 6574","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"12533459","citationType":"journal article","authors":["Pernestig A.-K.","Georgellis D.","Romeo T.","Suzuki K.","Tomenius H.","Normark S.","Melefors O."],"citationCrossReferences":[{"database":"PubMed","id":"12533459"},{"database":"DOI","id":"10.1128/jb.185.3.843-853.2003"}],"title":"The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources.","publicationDate":"2003","journal":"J. Bacteriol.","firstPage":"843","lastPage":"853","volume":"185"},"referencePositions":["FUNCTION"]},{"referenceNumber":8,"citation":{"id":"15919996","citationType":"journal article","authors":["Daley D.O.","Rapp M.","Granseth E.","Melen K.","Drew D.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"15919996"},{"database":"DOI","id":"10.1126/science.1109730"}],"title":"Global topology analysis of the Escherichia coli inner membrane proteome.","publicationDate":"2005","journal":"Science","firstPage":"1321","lastPage":"1323","volume":"308"},"referencePositions":["SUBCELLULAR LOCATION"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D10888","properties":[{"key":"ProteinId","value":"BAA01710.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U29580","properties":[{"key":"ProteinId","value":"AAA69296.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC75828.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAA16571.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S20550","properties":[{"key":"EntryName","value":"S20550"}]},{"database":"RefSeq","id":"NP_417266.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000186450.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P0AEC5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0AEC5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4262286","properties":[{"key":"Interactions","value":"27"}]},{"database":"BioGRID","id":"851585","properties":[{"key":"Interactions","value":"1"}]},{"database":"DIP","id":"DIP-47932N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P0AEC5","properties":[{"key":"Number of interactors","value":"525"}]},{"database":"IntAct","id":"P0AEC5","properties":[{"key":"Interactions","value":"4"}]},{"database":"STRING","id":"511145.b2786","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"P0AEC5","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P0AEC5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b2786","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC75828","properties":[{"key":"ProteinId","value":"AAC75828"},{"key":"GeneId","value":"b2786"}]},{"database":"GeneID","id":"75172870","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"75203823","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"947255","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW2757","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b2786","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_15320","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.3949","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB1341","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG2205","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"eggNOG","id":"COG3437","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"eggNOG","id":"COG3850","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"eggNOG","id":"COG4999","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_000445_104_1_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P0AEC5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NDATRYL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9770795at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P0AEC5","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:BARA-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:BARA-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P0AEC5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15919996"}]},{"database":"GO","id":"GO:0009927","properties":[{"key":"GoTerm","value":"F:histidine phosphotransfer kinase activity"},{"key":"GoEvidenceType","value":"IDA:EcoliWiki"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11022030"}]},{"database":"GO","id":"GO:0004721","properties":[{"key":"GoTerm","value":"F:phosphoprotein phosphatase activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16237014"}]},{"database":"GO","id":"GO:0000155","properties":[{"key":"GoTerm","value":"F:phosphorelay sensor kinase activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11022030"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20118252"}]},{"database":"GO","id":"GO:0004673","properties":[{"key":"GoTerm","value":"F:protein histidine kinase activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11022030"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16237014"}]},{"database":"GO","id":"GO:0010034","properties":[{"key":"GoTerm","value":"P:response to acetate"},{"key":"GoEvidenceType","value":"IEP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"20118252"}]},{"database":"GO","id":"GO:1901425","properties":[{"key":"GoTerm","value":"P:response to formic acid"},{"key":"GoEvidenceType","value":"IEP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"20118252"}]},{"database":"GO","id":"GO:0042542","properties":[{"key":"GoTerm","value":"P:response to hydrogen peroxide"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10931332"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11022030"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"EXP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1574005"}]},{"database":"CDD","id":"cd06225","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd16922","properties":[{"key":"EntryName","value":"HATPase_EvgS-ArcB-TorS-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00082","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00088","properties":[{"key":"EntryName","value":"HPT"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd17546","properties":[{"key":"EntryName","value":"REC_hyHK_CKI1_RcsC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.130:FF:000003","properties":[{"key":"EntryName","value":"Histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.160:FF:000002","properties":[{"key":"EntryName","value":"Histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.565.10:FF:000020","properties":[{"key":"EntryName","value":"Histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.2300:FF:000109","properties":[{"key":"EntryName","value":"Histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.130","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.340.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.160","properties":[{"key":"EntryName","value":"HPT domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011006","properties":[{"key":"EntryName","value":"CheY-like_superfamily"}]},{"database":"InterPro","id":"IPR003660","properties":[{"key":"EntryName","value":"HAMP_dom"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR003594","properties":[{"key":"EntryName","value":"HATPase_dom"}]},{"database":"InterPro","id":"IPR005467","properties":[{"key":"EntryName","value":"His_kinase_dom"}]},{"database":"InterPro","id":"IPR003661","properties":[{"key":"EntryName","value":"HisK_dim/P_dom"}]},{"database":"InterPro","id":"IPR036097","properties":[{"key":"EntryName","value":"HisK_dim/P_sf"}]},{"database":"InterPro","id":"IPR019247","properties":[{"key":"EntryName","value":"Histidine_kinase_BarA_N"}]},{"database":"InterPro","id":"IPR036641","properties":[{"key":"EntryName","value":"HPT_dom_sf"}]},{"database":"InterPro","id":"IPR004358","properties":[{"key":"EntryName","value":"Sig_transdc_His_kin-like_C"}]},{"database":"InterPro","id":"IPR008207","properties":[{"key":"EntryName","value":"Sig_transdc_His_kin_Hpt_dom"}]},{"database":"InterPro","id":"IPR001789","properties":[{"key":"EntryName","value":"Sig_transdc_resp-reg_receiver"}]},{"database":"NCBIfam","id":"NF008318","properties":[{"key":"EntryName","value":"PRK11107.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45339","properties":[{"key":"EntryName","value":"HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45339:SF1","properties":[{"key":"EntryName","value":"HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00672","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02518","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00512","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01627","properties":[{"key":"EntryName","value":"Hpt"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00072","properties":[{"key":"EntryName","value":"Response_reg"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09984","properties":[{"key":"EntryName","value":"sCache_4"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00344","properties":[{"key":"EntryName","value":"BCTRLSENSOR"}]},{"database":"SMART","id":"SM00304","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00387","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00388","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00073","properties":[{"key":"EntryName","value":"HPT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00448","properties":[{"key":"EntryName","value":"REC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52172","properties":[{"key":"EntryName","value":"CheY-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF158472","properties":[{"key":"EntryName","value":"HAMP domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47226","properties":[{"key":"EntryName","value":"Histidine-containing phosphotransfer domain, HPT domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47384","properties":[{"key":"EntryName","value":"Homodimeric domain of signal transducing histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50885","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50109","properties":[{"key":"EntryName","value":"HIS_KIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50894","properties":[{"key":"EntryName","value":"HPT"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50110","properties":[{"key":"EntryName","value":"RESPONSE_REGULATORY"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTNYSLRARMMILILAPTVLIGLLLSIFFVVHRYNDLQRQLEDAGASIIEPLAVSTEYGMSLQNRESIGQLISVLHRRHSDIVRAISVYDENNRLFVTSNFHLDPSSMQLGSNVPFPRQLTVTRDGDIMILRTPIISESYSPDESPSSDAKNSQNMLGYIALELDLKSVRLQQYKEIFISSVMMLFCIGIALIFGWRLMRDVTGPIRNMVNTVDRIRRGQLDSRVEGFMLGELDMLKNGINSMAMSLAAYHEEMQHNIDQATSDLRETLEQMEIQNVELDLAKKRAQEAARIKSEFLANMSHELRTPLNGVIGFTRLTLKTELTPTQRDHLNTIERSANNLLAIINDVLDFSKLEAGKLILESIPFPLRSTLDEVVTLLAHSSHDKGLELTLNIKSDVPDNVIGDPLRLQQIITNLVGNAIKFTENGNIDILVEKRALSNTKVQIEVQIRDTGIGIPERDQSRLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHINLDLNPNIIIEGPSTQCLAGKRLAYVEPNSAAAQCTLDILSETPLEVVYSPTFSALPPAHYDMMLLGIAVTFREPLTMQHERLAKAVSMTDFLMLALPCHAQVNAEKLKQDGIGACLLKPLTPTRLLPALTEFCHHKQNTLLPVTDESKLAMTVMAVDDNPANLKLIGALLEDMVQHVELCDSGHQAVERAKQMPFDLILMDIQMPDMDGIRACELIHQLPHQQQTPVIAVTAHAMAGQKEKLLGAGMSDYLAKPIEEERLHNLLLRYKPGSGISSRVVTPEVNEIVVNPNATLDWQLALRQAAGKTDLARDMLQMLLDFLPEVRNKVEEQLVGENPEGLVDLIHKLHGSCGYSGVPRMKNLCQLIEQQLRSGTKEEDLEPELLELLDEMDNVAREASKILG","length":918,"molWeight":102453,"crc64":"EA31D6D732F023CD","md5":"72978632C51F18B6449E7F060A82D213"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"PTM":1,"DISRUPTION PHENOTYPE":1},"countByFeatureType":{"Chain":1,"Topological domain":3,"Transmembrane":2,"Domain":4,"Modified residue":3},"uniParcId":"UPI000012678B"}}