{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0ADN4","secondaryAccessions":["P27827"],"uniProtkbId":"MAOP_ECO57","entryAudit":{"firstPublicDate":"2005-12-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":93,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Escherichia coli O157:H7","taxonId":83334,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0ADN2"}],"value":"Macrodomain Ori protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0ADN2"}],"value":"maoP"},"synonyms":[{"value":"yifE"}],"orderedLocusNames":[{"value":"Z5276"},{"value":"ECs4699"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0ADN2"}],"value":"Involved in the organization of the Ori region of the chromosome into a macrodomain (MD) (By similarity). It constrains DNA mobility in the Ori macrodomain and limits long-distance DNA interactions with other chromosomal regions (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MaoP family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Macrodomain Ori protein","featureId":"PRO_0000169642"},{"type":"Region","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11206551","citationType":"journal article","authors":["Perna N.T.","Plunkett G. III","Burland V.","Mau B.","Glasner J.D.","Rose D.J.","Mayhew G.F.","Evans P.S.","Gregor J.","Kirkpatrick H.A.","Posfai G.","Hackett J.","Klink S.","Boutin A.","Shao Y.","Miller L.","Grotbeck E.J.","Davis N.W.","Lim A.","Dimalanta E.T.","Potamousis K.","Apodaca J.","Anantharaman T.S.","Lin J.","Yen G.","Schwartz D.C.","Welch R.A.","Blattner F.R."],"citationCrossReferences":[{"database":"PubMed","id":"11206551"},{"database":"DOI","id":"10.1038/35054089"}],"title":"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.","publicationDate":"2001","journal":"Nature","firstPage":"529","lastPage":"533","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"O157:H7 / EDL933 / ATCC 700927 / EHEC","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"11258796","citationType":"journal article","authors":["Hayashi T.","Makino K.","Ohnishi M.","Kurokawa K.","Ishii K.","Yokoyama K.","Han C.-G.","Ohtsubo E.","Nakayama K.","Murata T.","Tanaka M.","Tobe T.","Iida T.","Takami H.","Honda T.","Sasakawa C.","Ogasawara N.","Yasunaga T.","Kuhara S.","Shiba T.","Hattori M.","Shinagawa H."],"citationCrossReferences":[{"database":"PubMed","id":"11258796"},{"database":"DOI","id":"10.1093/dnares/8.1.11"}],"title":"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12.","publicationDate":"2001","journal":"DNA Res.","firstPage":"11","lastPage":"22","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"O157:H7 / Sakai / RIMD 0509952 / EHEC","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AE005174","properties":[{"key":"ProteinId","value":"AAG58960.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BA000007","properties":[{"key":"ProteinId","value":"BAB38122.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"C91216","properties":[{"key":"EntryName","value":"C91216"}]},{"database":"PIR","id":"D86062","properties":[{"key":"EntryName","value":"D86062"}]},{"database":"RefSeq","id":"NP_312726.1","properties":[{"key":"NucleotideSequenceId","value":"NC_002695.2"}]},{"database":"RefSeq","id":"WP_000841001.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_AP018488.1"}]},{"database":"AlphaFoldDB","id":"P0ADN4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0ADN4","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"155864.Z5276","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"67174666","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"915294","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"93778186","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ece:Z5276","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecs:ECs_4699","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|386585.9.peg.4905","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"eggNOG","id":"COG3085","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_144599_2_2_6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CRGIREP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"Proteomes","id":"UP000000558","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"InterPro","id":"IPR007335","properties":[{"key":"EntryName","value":"DUF413"}]},{"database":"NCBIfam","id":"NF008251","properties":[{"key":"EntryName","value":"PRK11027.1-1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF008252","properties":[{"key":"EntryName","value":"PRK11027.1-2"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF008253","properties":[{"key":"EntryName","value":"PRK11027.1-4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04219","properties":[{"key":"EntryName","value":"DUF413"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAESFTTTNRYFDNKHYPRGFSRHGDFTIKEAQLLERHGYAFNELDLGKREPVTEEEKLFVAVCRGEREPVTEAERVWSKYMTRIKRPKRFHTLSGGKPQVEGAEDYTDSDD","length":112,"molWeight":13134,"crc64":"EB2F585318770224","md5":"E9F588040B00F0A765A09EDB29D4DC3C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000163A3F"}}