{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0ADM0","secondaryAccessions":["P31445","Q2M7Y9"],"uniProtkbId":"YIDH_ECOLI","entryAudit":{"firstPublicDate":"2005-12-06","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2005-12-06","entryVersion":113,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Inner membrane protein YidH"}}},"genes":[{"geneName":{"value":"yidH"},"orderedLocusNames":[{"value":"b3676"},{"value":"JW3652"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cell inner membrane","id":"SL-0037"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"To M.tuberculosis Rv2272"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Inner membrane protein YidH","featureId":"PRO_0000169628"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0997","category":"Cellular component","name":"Cell inner membrane"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"7686882","citationType":"journal article","authors":["Burland V.D.","Plunkett G. III","Daniels D.L.","Blattner F.R."],"citationCrossReferences":[{"database":"PubMed","id":"7686882"},{"database":"DOI","id":"10.1006/geno.1993.1230"}],"title":"DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.","publicationDate":"1993","journal":"Genomics","firstPage":"551","lastPage":"561","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"15919996","citationType":"journal article","authors":["Daley D.O.","Rapp M.","Granseth E.","Melen K.","Drew D.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"15919996"},{"database":"DOI","id":"10.1126/science.1109730"}],"title":"Global topology analysis of the Escherichia coli inner membrane proteome.","publicationDate":"2005","journal":"Science","firstPage":"1321","lastPage":"1323","volume":"308"},"referencePositions":["TOPOLOGY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L10328","properties":[{"key":"ProteinId","value":"AAA62028.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC76699.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE77617.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"E65169","properties":[{"key":"EntryName","value":"E65169"}]},{"database":"RefSeq","id":"NP_418132.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000703959.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P0ADM0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0ADM0","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4262587","properties":[{"key":"Interactions","value":"6"}]},{"database":"DIP","id":"DIP-47894N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P0ADM0","properties":[{"key":"Number of interactors","value":"5"}]},{"database":"STRING","id":"511145.b3676","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.B.51.1.1","properties":[{"key":"FamilyName","value":"the uncharacterized duf202/yidh (yidh) family"}]},{"database":"PaxDb","id":"511145-b3676","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC76699","properties":[{"key":"ProteinId","value":"AAC76699"},{"key":"GeneId","value":"b3676"}]},{"database":"GeneID","id":"93778418","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"948190","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW3652","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b3676","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_19935","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|511145.12.peg.3797","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB1647","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG2149","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_053359_4_1_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P0ADM0","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NHWVRCE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"582337at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P0ADM0","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:EG11696-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P0ADM0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15919996"}]},{"database":"GO","id":"GO:0006979","properties":[{"key":"GoTerm","value":"P:response to oxidative stress"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24580753"}]},{"database":"InterPro","id":"IPR003807","properties":[{"key":"EntryName","value":"DUF202"}]},{"database":"InterPro","id":"IPR052053","properties":[{"key":"EntryName","value":"IM_YidH-like"}]},{"database":"PANTHER","id":"PTHR34187:SF2","properties":[{"key":"EntryName","value":"DUF202 DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34187","properties":[{"key":"EntryName","value":"FGR18P"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02656","properties":[{"key":"EntryName","value":"DUF202"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKISRLGEAPDYRFSLANERTFLAWIRTALGFLAAGVGLDQLAPDFATPVIRELLALLLCLFSGGLAMYGYLRWLRNEKAMRLKEDLPYTNSLLIISLILMVVAVIVMGLVLYAG","length":115,"molWeight":12779,"crc64":"59E08E0F3EA7125A","md5":"EA3BB3B2B3D8F47B24456920EDFEFE29"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":4,"Transmembrane":3},"uniParcId":"UPI000013B3B2"}}