{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0AC30","secondaryAccessions":["P10122","Q2M7C5"],"uniProtkbId":"FTSX_ECOLI","entryAudit":{"firstPublicDate":"2005-11-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-11-08","entryVersion":141,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cell division protein FtsX"}}},"genes":[{"geneName":{"value":"ftsX"},"synonyms":[{"value":"ftsS"}],"orderedLocusNames":[{"value":"b3462"},{"value":"JW3427"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10048040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14729705"}],"value":"Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. Encoded in an operon consisting of genes ftsY, ftsE and ftsX"}],"commentType":"FUNCTION"},{"texts":[{"value":"Forms a membrane-associated complex with FtsE"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P0AC30","intActId":"EBI-1119111"},"interactantTwo":{"uniProtKBAccession":"P37690","geneName":"envC","intActId":"EBI-15948725"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Localizes to the septal ring at the later stages of cell growth and remains there until division is complete. This localization is dependent on localization of FtsZ, FtsA and ZipA, but not on the downstream division proteins FtsK, FtsQ or FtsI"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10048040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14729705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3323846"}],"value":"Cell inner membrane","id":"SL-0037"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10048040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14729705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3323846"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071757"}],"value":"Double deletion mutant FtsEX grows well on plates with LB medium with 1% NaCl forming healthy colonies at 30 degrees Celsius, whereas at 37 or 42 degrees Celsius, the colonies are very tiny and sick. In culture medium it exhibits mild elongation of cells at 30 degrees Celsius, and become very extensive at higher temperatures. This double mutant does not grow on LB culture medium without NaCl (LBON) at any temperature, possibly due to excessive lethal filamentation. Supplementation with any of a variety of osmolytes, such as glucose, sucrose, glycerol, or NaCl, completely rescues the growth on LBON medium. Though the growth is completely inhibited on LBON plates, the cultures grown in LBON broth show an initial increase in cell mass before the cessation of growth, and at this stage, the culture is extremely filamentous. The filaments grown in LB at 42 degrees Celsius or in LBON at 30 degrees Celsius are very long and appear to have elongated cells. They are normal and regularly spaced without any significant chromosomal aberrations or partition defects"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"value":"Overexpression leads to strong inhibition of growth, cell filamentation and eventually cell death"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ABC-4 integral membrane protein family. FtsX subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Cell division protein FtsX","featureId":"PRO_0000166792"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Helix","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YMC"}]},{"type":"Helix","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YMC"}]},{"type":"Beta strand","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Beta strand","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9IUE"}]},{"type":"Helix","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Beta strand","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8HD0"}]},{"type":"Beta strand","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Helix","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Beta strand","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8HD0"}]},{"type":"Turn","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Helix","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Beta strand","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YMC"}]},{"type":"Helix","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Beta strand","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Helix","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Helix","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Beta strand","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8HD0"}]},{"type":"Beta strand","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPI"}]},{"type":"Helix","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YMC"}]},{"type":"Helix","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YMC"}]},{"type":"Helix","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YMC"}]},{"type":"Helix","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8HD0"}]},{"type":"Helix","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YMC"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0997","category":"Cellular component","name":"Cell inner membrane"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"3025556","citationType":"journal article","authors":["Gill D.R.","Hatfull G.F.","Salmond G.P.C."],"citationCrossReferences":[{"database":"PubMed","id":"3025556"},{"database":"DOI","id":"10.1007/bf02428043"}],"title":"A new cell division operon in Escherichia coli.","publicationDate":"1986","journal":"Mol. Gen. Genet.","firstPage":"134","lastPage":"145","volume":"205"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"K12","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"8041620","citationType":"journal article","authors":["Sofia H.J.","Burland V.","Daniels D.L.","Plunkett G. III","Blattner F.R."],"citationCrossReferences":[{"database":"PubMed","id":"8041620"},{"database":"DOI","id":"10.1093/nar/22.13.2576"}],"title":"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.","publicationDate":"1994","journal":"Nucleic Acids Res.","firstPage":"2576","lastPage":"2586","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"6394955","citationType":"journal article","authors":["Salmond G.P.","Plakidou S."],"citationCrossReferences":[{"database":"PubMed","id":"6394955"},{"database":"DOI","id":"10.1007/bf00330978"}],"title":"Genetic analysis of essential genes in the ftsE region of the Escherichia coli genetic map and identification of a new cell division gene, ftsS.","publicationDate":"1984","journal":"Mol. Gen. Genet.","firstPage":"304","lastPage":"308","volume":"197"},"referencePositions":["GENE NAME"]},{"referenceNumber":6,"citation":{"id":"3323846","citationType":"journal article","authors":["Gill D.R.","Salmond G.P."],"citationCrossReferences":[{"database":"PubMed","id":"3323846"},{"database":"DOI","id":"10.1007/bf00327204"}],"title":"The Escherichia coli cell division proteins FtsY, FtsE and FtsX are inner membrane-associated.","publicationDate":"1987","journal":"Mol. Gen. Genet.","firstPage":"504","lastPage":"508","volume":"210"},"referencePositions":["SUBCELLULAR LOCATION","OPERON STRUCTURE"]},{"referenceNumber":7,"citation":{"id":"10048040","citationType":"journal article","authors":["de Leeuw E.","Graham B.","Phillips G.J.","ten Hagen-Jongman C.M.","Oudega B.","Luirink J."],"citationCrossReferences":[{"database":"PubMed","id":"10048040"},{"database":"DOI","id":"10.1046/j.1365-2958.1999.01245.x"}],"title":"Molecular characterization of Escherichia coli FtsE and FtsX.","publicationDate":"1999","journal":"Mol. Microbiol.","firstPage":"983","lastPage":"993","volume":"31"},"referencePositions":["FUNCTION","INTERACTION WITH FTSE","SUBCELLULAR LOCATION","OVEREXPRESSION"]},{"referenceNumber":8,"citation":{"id":"14729705","citationType":"journal article","authors":["Schmidt K.L.","Peterson N.D.","Kustusch R.J.","Wissel M.C.","Graham B.","Phillips G.J.","Weiss D.S."],"citationCrossReferences":[{"database":"PubMed","id":"14729705"},{"database":"DOI","id":"10.1128/jb.186.3.785-793.2004"}],"title":"A predicted ABC transporter, FtsEX, is needed for cell division in Escherichia coli.","publicationDate":"2004","journal":"J. Bacteriol.","firstPage":"785","lastPage":"793","volume":"186"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":9,"citation":{"id":"15919996","citationType":"journal article","authors":["Daley D.O.","Rapp M.","Granseth E.","Melen K.","Drew D.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"15919996"},{"database":"DOI","id":"10.1126/science.1109730"}],"title":"Global topology analysis of the Escherichia coli inner membrane proteome.","publicationDate":"2005","journal":"Science","firstPage":"1321","lastPage":"1323","volume":"308"},"referencePositions":["TOPOLOGY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":10,"citation":{"id":"17071757","citationType":"journal article","authors":["Reddy M."],"citationCrossReferences":[{"database":"PubMed","id":"17071757"},{"database":"DOI","id":"10.1128/jb.01347-06"}],"title":"Role of FtsEX in cell division of Escherichia coli: viability of ftsEX mutants is dependent on functional SufI or high osmotic strength.","publicationDate":"2007","journal":"J. Bacteriol.","firstPage":"98","lastPage":"108","volume":"189"},"referencePositions":["DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"K12","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X04398","properties":[{"key":"ProteinId","value":"CAA27986.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00039","properties":[{"key":"ProteinId","value":"AAB18437.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC76487.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE77831.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S03132","properties":[{"key":"EntryName","value":"CEECFX"}]},{"database":"RefSeq","id":"NP_417919.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_001042003.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"PDB","id":"6TPI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B/C=110-209"}]},{"database":"PDB","id":"8HD0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.11 A"},{"key":"Chains","value":"C/D=1-352"}]},{"database":"PDB","id":"8W6I","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"A/C=1-352"}]},{"database":"PDB","id":"8W6J","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A/C=1-352"}]},{"database":"PDB","id":"8X61","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"C/D=1-352"}]},{"database":"PDB","id":"8Y3X","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.11 A"},{"key":"Chains","value":"C/D=1-352"}]},{"database":"PDB","id":"8YMC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"C/D=19-352"}]},{"database":"PDB","id":"9IUE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A/B/C/D/I/J/O/P/U/V/a/b/g/h/m/n/s/t=1-352"}]},{"database":"PDBsum","id":"6TPI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HD0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8W6I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8W6J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8X61","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Y3X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8YMC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9IUE","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P0AC30","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34668","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37324","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37325","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38077","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38906","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-39394","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60898","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0AC30","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4262498","properties":[{"key":"Interactions","value":"608"}]},{"database":"ComplexPortal","id":"CPX-4602","properties":[{"key":"EntryName","value":"FtsEX ABC cell division complex"}]},{"database":"DIP","id":"DIP-35993N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P0AC30","properties":[{"key":"Number of interactors","value":"339"}]},{"database":"IntAct","id":"P0AC30","properties":[{"key":"Interactions","value":"7"}]},{"database":"STRING","id":"511145.b3462","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3309011","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P0AC30","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b3462","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC76487","properties":[{"key":"ProteinId","value":"AAC76487"},{"key":"GeneId","value":"b3462"}]},{"database":"GeneID","id":"93778529","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"947969","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW3427","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b3462","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_18755","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|511145.12.peg.3561","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB0341","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG2177","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_073546_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P0AC30","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"IKTMQMV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9813411at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P0AC30","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:FTSX-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P0AC30","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:1904949","properties":[{"key":"GoTerm","value":"C:ATPase complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10048040"}]},{"database":"GO","id":"GO:0032153","properties":[{"key":"GoTerm","value":"C:cell division site"},{"key":"GoEvidenceType","value":"IDA:EcoliWiki"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14729705"}]},{"database":"GO","id":"GO:0000935","properties":[{"key":"GoTerm","value":"C:division septum"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14729705"}]},{"database":"GO","id":"GO:1990586","properties":[{"key":"GoTerm","value":"C:divisome complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28419603"}]},{"database":"GO","id":"GO:0009276","properties":[{"key":"GoTerm","value":"C:Gram-negative-bacterium-type cell wall"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10048040"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"3323846"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10048040"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15919996"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17309111"}]},{"database":"GO","id":"GO:0098797","properties":[{"key":"GoTerm","value":"C:plasma membrane protein complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10048040"}]},{"database":"GO","id":"GO:0051301","properties":[{"key":"GoTerm","value":"P:cell division"},{"key":"GoEvidenceType","value":"IMP:EcoliWiki"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14729705"}]},{"database":"GO","id":"GO:0000917","properties":[{"key":"GoTerm","value":"P:division septum assembly"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28419603"}]},{"database":"GO","id":"GO:0043093","properties":[{"key":"GoTerm","value":"P:FtsZ-dependent cytokinesis"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28419603"}]},{"database":"GO","id":"GO:0009254","properties":[{"key":"GoTerm","value":"P:peptidoglycan turnover"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22006326"}]},{"database":"GO","id":"GO:0051781","properties":[{"key":"GoTerm","value":"P:positive regulation of cell division"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14729705"}]},{"database":"FunFam","id":"3.30.70.3040:FF:000001","properties":[{"key":"EntryName","value":"Cell division protein FtsX"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.3040","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003838","properties":[{"key":"EntryName","value":"ABC3_permease_C"}]},{"database":"InterPro","id":"IPR004513","properties":[{"key":"EntryName","value":"FtsX"}]},{"database":"InterPro","id":"IPR040690","properties":[{"key":"EntryName","value":"FtsX_ECD"}]},{"database":"InterPro","id":"IPR047590","properties":[{"key":"EntryName","value":"FtsX_proteobact-type"}]},{"database":"NCBIfam","id":"TIGR00439","properties":[{"key":"EntryName","value":"FtsX_Gneg"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47755","properties":[{"key":"EntryName","value":"CELL DIVISION PROTEIN FTSX"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47755:SF1","properties":[{"key":"EntryName","value":"CELL DIVISION PROTEIN FTSX"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02687","properties":[{"key":"EntryName","value":"FtsX"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18075","properties":[{"key":"EntryName","value":"FtsX_ECD"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF003097","properties":[{"key":"EntryName","value":"FtsX"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNKRDAINHIRQFGGRLDRFRKSVGGSGDGGRNAPKRAKSSPKPVNRKTNVFNEQVRYAFHGALQDLKSKPFATFLTVMVIAISLTLPSVCYMVYKNVNQAATQYYPSPQITVYLQKTLDDDAAAGVVAQLQAEQGVEKVNYLSREDALGEFRNWSGFGGALDMLEENPLPAVAVVIPKLDFQGTESLNTLRDRITQINGIDEVRMDDSWFARLAALTGLVGRVSAMIGVLMVAAVFLVIGNSVRLSIFARRDSINVQKLIGATDGFILRPFLYGGALLGFSGALLSLILSEILVLRLSSAVAEVAQVFGTKFDINGLSFDECLLLLLVCSMIGWVAAWLATVQHLRHFTPE","length":352,"molWeight":38544,"crc64":"C006ED56043739AE","md5":"3ED844D1B49FBE63AFCFC819444FDA72"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"DISRUPTION PHENOTYPE":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":5,"Transmembrane":4,"Region":1,"Helix":13,"Beta strand":9,"Turn":1},"uniParcId":"UPI000012ACFE"}}