{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0AAQ0","secondaryAccessions":["P77273","Q2MC45"],"uniProtkbId":"YAIZ_ECOLI","entryAudit":{"firstPublicDate":"2005-10-11","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2005-10-11","entryVersion":112,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein YaiZ"}}},"genes":[{"geneName":{"value":"yaiZ"},"orderedLocusNames":[{"value":"b0380"},{"value":"JW5053"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAB18103.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Uncharacterized protein YaiZ","featureId":"PRO_0000168602"},{"type":"Transmembrane","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-B1UJ6TNQ0SAS1","citationType":"submission","authors":["Chung E.","Allen E.","Araujo R.","Aparicio A.M.","Davis K.","Duncan M.","Federspiel N.","Hyman R.","Kalman S.","Komp C.","Kurdi O.","Lew H.","Lin D.","Namath A.","Oefner P.","Roberts D.","Schramm S.","Davis R.W."],"title":"Sequence of minutes 4-25 of Escherichia coli.","publicationDate":"JAN-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U73857","properties":[{"key":"ProteinId","value":"AAB18103.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC73483.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE76161.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"D64766","properties":[{"key":"EntryName","value":"D64766"}]},{"database":"RefSeq","id":"NP_414914.2","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_001295334.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P0AAQ0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0AAQ0","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4259826","properties":[{"key":"Interactions","value":"3"}]},{"database":"FunCoup","id":"P0AAQ0","properties":[{"key":"Number of interactors","value":"159"}]},{"database":"STRING","id":"511145.b0380","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.B.382.1.1","properties":[{"key":"FamilyName","value":"the duf2754 domain or yaiz (duf2754) family"}]},{"database":"PaxDb","id":"511145-b0380","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC73483","properties":[{"key":"ProteinId","value":"AAC73483"},{"key":"GeneId","value":"b0380"}]},{"database":"GeneID","id":"93777082","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"947355","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW5053","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b0380","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_01835","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.1898","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB4028","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG5032T5P","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_2600729_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P0AAQ0","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LIFIMNG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6563899at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P0AAQ0","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:G6229-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P0AAQ0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20333498"}]},{"database":"InterPro","id":"IPR020490","properties":[{"key":"EntryName","value":"Uncharacterised_YaiZ"}]},{"database":"Pfam","id":"PF10953","properties":[{"key":"EntryName","value":"DUF2754"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNLPVKIRRDWHYYAFAIGLIFILNGVVGLLGFEAKGWQTYAVGLVTWVISFWLAGLIIRRRDEETENAQ","length":70,"molWeight":8097,"crc64":"10EB267CCED4BCEA","md5":"48ECA8134A8510CA6323F54C8427D41E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Transmembrane":2},"uniParcId":"UPI000013A0DF"}}