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In the absence of formaldehyde, mediates repression of the frmRAB operon (PubMed:15466022, PubMed:27934966). Acts by binding directly to the frmRAB promoter region (PubMed:27934966). In the presence of formaldehyde, it dissociates from the frmRAB promoter region and allows expression of the formaldehyde detoxification system encoded by frmA and frmB (PubMed:27934966). It senses the toxic chemical formaldehyde directly, with no metal-dependence (PubMed:27934966)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27934966"}],"value":"The presence of formaldehyde leads to the formation of methylene bridges between Pro-2 and Cys-35 residues of adjacent subunits, which remodels the surface of the tetramer (PubMed:27934966). These conformational changes lead to de-repression of frmRAB expression by promoting disassociation of FrmR from the frmRAB promoter region (PubMed:27934966). Can bind Zn(II), however Zn(II) blocks amino acid residues required for formaldehyde sensing (PubMed:27934966). It is likely that Zn(II) could only inhibit FrmR activity in vivo under conditions when Zn(II) homeostasis is severely perturbed (PubMed:27934966)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27934966"}],"value":"Homotetramer (PubMed:27934966). Dimer of dimers (PubMed:27934966)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15466022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16549663"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27934966"}],"value":"Negatively autoregulated (PubMed:15466022). Induced by formaldehyde (PubMed:15466022, PubMed:27934966). Also induced by acetaldehyde, methylglyoxal and glyoxal, albeit to lesser extents (PubMed:27934966). Markedly induced (41-fold) by polyhexamethylene biguanide (PHMB), a broad-spectrum antibacterial agent, but overexpression of the gene causes no change in PHMB sensitivity (PubMed:16549663). Not induced by S-nitrosoglutathione or bulky aldehydes, such as furaldehyde and tribromoacetaldehyde (PubMed:15466022, PubMed:27934966)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the FrmR/RcnR family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAB18082.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"D85613","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27934966"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Transcriptional repressor FrmR","featureId":"PRO_0000168591"},{"type":"Site","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"Important for response to formaldehyde","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27934966"}]},{"type":"Site","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Important for response to formaldehyde","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27934966"}]},{"type":"Mutagenesis","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"Fails to respond to formaldehyde. 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