{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0A898","secondaryAccessions":["P77385"],"uniProtkbId":"YBEY_ECOLI","entryAudit":{"firstPublicDate":"2005-04-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-04-26","entryVersion":148,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00009"}],"value":"Endoribonuclease YbeY"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00009"}],"value":"3.1.-.-"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00009"}],"value":"ybeY"},"orderedLocusNames":[{"value":"b0659"},{"value":"JW0656"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00009"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16511207"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20639334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20807199"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23273979"}],"value":"Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. Acts together with the RNase R to eliminate defective 70S ribosomes, but not properly matured 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. Involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'- and 3'-ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00009"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00009"}],"value":"Binds 1 zinc ion."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23273979"}],"value":"Inhibited by EDTA"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P0A898","intActId":"EBI-560240"},"interactantTwo":{"uniProtKBAccession":"P0DTT0","geneName":"bipA","intActId":"EBI-562154"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P0A898","intActId":"EBI-560240"},"interactantTwo":{"uniProtKBAccession":"P0A9K3","geneName":"ybeZ","intActId":"EBI-560255"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00009"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20639334"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16818608"}],"value":"By heat shock"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19181801"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20639334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20807199"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23273979"}],"value":"Mutants show defects in 16S rRNA maturation, ribosome activity, translational fidelity, and ribosome assembly. They have severe growth defect at high temperatures, essentially no thermotolerance at lethal temperatures. They also show a decrease in polysomes and a large increase in both free 50S and free 30S ribosomal subunits relative to 70S ribosomes"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00009"}],"value":"Belongs to the endoribonuclease YbeY family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"Endoribonuclease YbeY","featureId":"PRO_0000102449"},{"type":"Binding site","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Mutagenesis","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Loss of activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20807199"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23273979"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A","E"]}},{"type":"Mutagenesis","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Loss of activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20807199"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23273979"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"No change in activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20807199"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"No change in activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20807199"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Beta strand","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Beta strand","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Helix","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Helix","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Beta strand","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Helix","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Beta strand","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Helix","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Beta strand","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Helix","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Helix","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]},{"type":"Helix","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1XM5"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0690","category":"Biological process","name":"Ribosome biogenesis"},{"id":"KW-0698","category":"Biological process","name":"rRNA processing"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"8905232","citationType":"journal article","authors":["Oshima T.","Aiba H.","Baba T.","Fujita K.","Hayashi K.","Honjo A.","Ikemoto K.","Inada T.","Itoh T.","Kajihara M.","Kanai K.","Kashimoto K.","Kimura S.","Kitagawa M.","Makino K.","Masuda S.","Miki T.","Mizobuchi K.","Mori H.","Motomura K.","Nakamura Y.","Nashimoto H.","Nishio Y.","Saito N.","Sampei G.","Seki Y.","Tagami H.","Takemoto K.","Wada C.","Yamamoto Y.","Yano M.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"8905232"},{"database":"DOI","id":"10.1093/dnares/3.3.137"}],"title":"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.","publicationDate":"1996","journal":"DNA Res.","firstPage":"137","lastPage":"155","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"CI-B1UJ6TNQ0SAS1","citationType":"submission","authors":["Chung E.","Allen E.","Araujo R.","Aparicio A.M.","Davis K.","Duncan M.","Federspiel N.","Hyman R.","Kalman S.","Komp C.","Kurdi O.","Lew H.","Lin D.","Namath A.","Oefner P.","Roberts D.","Schramm S.","Davis R.W."],"title":"Sequence of minutes 4-25 of Escherichia coli.","publicationDate":"JAN-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"16818608","citationType":"journal article","authors":["Nonaka G.","Blankschien M.","Herman C.","Gross C.A.","Rhodius V.A."],"citationCrossReferences":[{"database":"PubMed","id":"16818608"},{"database":"DOI","id":"10.1101/gad.1428206"}],"title":"Regulon and promoter analysis of the E. coli heat-shock factor, sigma32, reveals a multifaceted cellular response to heat stress.","publicationDate":"2006","journal":"Genes Dev.","firstPage":"1776","lastPage":"1789","volume":"20"},"referencePositions":["INDUCTION"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"19181801","citationType":"journal article","authors":["Rasouly A.","Schonbrun M.","Shenhar Y.","Ron E.Z."],"citationCrossReferences":[{"database":"PubMed","id":"19181801"},{"database":"DOI","id":"10.1128/jb.01663-08"}],"title":"YbeY, a heat shock protein involved in translation in Escherichia coli.","publicationDate":"2009","journal":"J. Bacteriol.","firstPage":"2649","lastPage":"2655","volume":"191"},"referencePositions":["DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"20639334","citationType":"journal article","authors":["Rasouly A.","Davidovich C.","Ron E.Z."],"citationCrossReferences":[{"database":"PubMed","id":"20639334"},{"database":"DOI","id":"10.1128/jb.00448-10"}],"title":"The heat shock protein YbeY is required for optimal activity of the 30S ribosomal subunit.","publicationDate":"2010","journal":"J. Bacteriol.","firstPage":"4592","lastPage":"4596","volume":"192"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":8,"citation":{"id":"20807199","citationType":"journal article","authors":["Davies B.W.","Kohrer C.","Jacob A.I.","Simmons L.A.","Zhu J.","Aleman L.M.","Rajbhandary U.L.","Walker G.C."],"citationCrossReferences":[{"database":"PubMed","id":"20807199"},{"database":"DOI","id":"10.1111/j.1365-2958.2010.07351.x"}],"title":"Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing.","publicationDate":"2010","journal":"Mol. Microbiol.","firstPage":"506","lastPage":"518","volume":"78"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE","MUTAGENESIS OF ARG-59; HIS-114; HIS-118 AND HIS-124"],"referenceComments":[{"value":"K12 / MC4100 / ATCC 35695 / DSM 6574","type":"STRAIN"}]},{"referenceNumber":9,"citation":{"id":"23273979","citationType":"journal article","authors":["Jacob A.I.","Kohrer C.","Davies B.W.","Rajbhandary U.L.","Walker G.C."],"citationCrossReferences":[{"database":"PubMed","id":"23273979"},{"database":"DOI","id":"10.1016/j.molcel.2012.11.025"}],"title":"Conserved bacterial RNase YbeY plays key roles in 70S ribosome quality control and 16S rRNA maturation.","publicationDate":"2013","journal":"Mol. Cell","firstPage":"427","lastPage":"438","volume":"49"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","DISRUPTION PHENOTYPE","MUTAGENESIS OF ARG-59 AND HIS-114"],"referenceComments":[{"value":"K12 / MC4100 / ATCC 35695 / DSM 6574","type":"STRAIN"}]},{"referenceNumber":10,"citation":{"id":"16511207","citationType":"journal article","authors":["Zhan C.","Fedorov E.V.","Shi W.","Ramagopal U.A.","Thirumuruhan R.","Manjasetty B.A.","Almo S.C.","Fiser A.","Chance M.R.","Fedorov A.A."],"citationCrossReferences":[{"database":"PubMed","id":"16511207"},{"database":"DOI","id":"10.1107/s1744309105031131"}],"title":"The ybeY protein from Escherichia coli is a metalloprotein.","publicationDate":"2005","journal":"Acta Crystallogr. F","firstPage":"959","lastPage":"963","volume":"61"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) IN COMPLEX WITH DIVALENT METAL CATIONS","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U82598","properties":[{"key":"ProteinId","value":"AAB40861.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC73760.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAA35314.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A64801","properties":[{"key":"EntryName","value":"A64801"}]},{"database":"RefSeq","id":"NP_415192.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000084469.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"PDB","id":"1XM5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/C/D=1-155"}]},{"database":"PDBsum","id":"1XM5","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P0A898","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0A898","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4261388","properties":[{"key":"Interactions","value":"80"}]},{"database":"DIP","id":"DIP-48144N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P0A898","properties":[{"key":"Number of interactors","value":"304"}]},{"database":"IntAct","id":"P0A898","properties":[{"key":"Interactions","value":"15"}]},{"database":"STRING","id":"511145.b0659","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P0A898","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b0659","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"946430","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC73760","properties":[{"key":"ProteinId","value":"AAC73760"},{"key":"GeneId","value":"b0659"}]},{"database":"GeneID","id":"93776823","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"946430","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW0656","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b0659","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_03295","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.1609","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB3419","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG0319","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_106710_0_1_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P0A898","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RMRIHPL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9807740at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P0A898","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:G6362-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"P0A898","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P0A898","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P0A898","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004222","properties":[{"key":"GoTerm","value":"F:metalloendopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016151","properties":[{"key":"GoTerm","value":"F:nickel cation binding"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16511207"}]},{"database":"GO","id":"GO:0016892","properties":[{"key":"GoTerm","value":"F:RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23273979"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0030490","properties":[{"key":"GoTerm","value":"P:maturation of SSU-rRNA"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20807199"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24901994"}]},{"database":"GO","id":"GO:0009408","properties":[{"key":"GoTerm","value":"P:response to heat"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19181801"}]},{"database":"GO","id":"GO:0042274","properties":[{"key":"GoTerm","value":"P:ribosomal small subunit biogenesis"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20639334"}]},{"database":"GO","id":"GO:0042254","properties":[{"key":"GoTerm","value":"P:ribosome biogenesis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20807199"}]},{"database":"GO","id":"GO:0006364","properties":[{"key":"GoTerm","value":"P:rRNA processing"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20807199"}]},{"database":"GO","id":"GO:0031564","properties":[{"key":"GoTerm","value":"P:transcription antitermination"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23638028"}]},{"database":"GO","id":"GO:0006412","properties":[{"key":"GoTerm","value":"P:translation"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19181801"}]},{"database":"FunFam","id":"3.40.390.30:FF:000001","properties":[{"key":"EntryName","value":"Endoribonuclease YbeY"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.30","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00009","properties":[{"key":"EntryName","value":"Endoribonucl_YbeY"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023091","properties":[{"key":"EntryName","value":"MetalPrtase_cat_dom_sf_prd"}]},{"database":"InterPro","id":"IPR002036","properties":[{"key":"EntryName","value":"YbeY"}]},{"database":"InterPro","id":"IPR020549","properties":[{"key":"EntryName","value":"YbeY_CS"}]},{"database":"NCBIfam","id":"TIGR00043","properties":[{"key":"EntryName","value":"rRNA maturation RNase YbeY"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46986","properties":[{"key":"EntryName","value":"ENDORIBONUCLEASE YBEY, CHLOROPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46986:SF1","properties":[{"key":"EntryName","value":"ENDORIBONUCLEASE YBEY, CHLOROPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02130","properties":[{"key":"EntryName","value":"YbeY"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01306","properties":[{"key":"EntryName","value":"UPF0054"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSQVILDLQLACEDNSGLPEESQFQTWLNAVIPQFQEESEVTIRVVDTAESHSLNLTYRGKDKPTNVLSFPFEVPPGMEMSLLGDLVICRQVVEKEAQEQGKPLEAHWAHMVVHGSLHLLGYDHIEDDEAEEMEALETEIMLALGYEDPYIAEKE","length":155,"molWeight":17526,"crc64":"C0DAC40266F846A5","md5":"83B737FFB679080AA9C0D56ED58FF728"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"ACTIVITY REGULATION":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Binding site":3,"Mutagenesis":4,"Beta strand":5,"Helix":7},"uniParcId":"UPI000013A30C"}}