{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P09683","uniProtkbId":"SECR_HUMAN","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-01-11","entryVersion":189,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11060443"}],"value":"Secretin"}},"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11060443"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:10607"}],"value":"SCT"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11384"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q08535"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32811827"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33008599"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25332973"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"30449620"}],"value":"Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973). Exerts its biological effects by binding to secretin receptor (SCTR), a G protein-coupled receptor expressed in the basolateral domain of several cells (PubMed:25332973, PubMed:33008599, PubMed:32811827). Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (By similarity). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (Probable). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P09683","intActId":"EBI-12844598"},"interactantTwo":{"uniProtKBAccession":"O14964","geneName":"HGS","intActId":"EBI-740220"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09683","intActId":"EBI-12844598"},"interactantTwo":{"uniProtKBAccession":"P49639","geneName":"HOXA1","intActId":"EBI-740785"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09683","intActId":"EBI-12844598"},"interactantTwo":{"uniProtKBAccession":"O14770-4","geneName":"MEIS2","intActId":"EBI-8025850"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09683","intActId":"EBI-12844598"},"interactantTwo":{"uniProtKBAccession":"Q8N6Y0","geneName":"USHBP1","intActId":"EBI-739895"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.2"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30449620"}],"value":"Serum secretin levels are increased after single-meal ingestion"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the glucagon family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Secretin","ftp":false,"note":"Secretin entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.2"}],"featureId":"PRO_0000011423"},{"type":"Peptide","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Secretin","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.2"}],"featureId":"PRO_0000011424"},{"type":"Propeptide","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.2"}],"featureId":"PRO_0000011425"},{"type":"Modified residue","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Valine amide","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.2"}]},{"type":"Modified residue","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11384"}]},{"type":"Helix","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WZG"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0027","category":"PTM","name":"Amidation"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0372","category":"Molecular function","name":"Hormone"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11060443","citationType":"journal article","authors":["Whitmore T.E.","Holloway J.L.","Lofton-Day C.E.","Maurer M.F.","Chen L.","Quinton T.J.","Vincent J.B.","Scherer S.W.","Lok S."],"citationCrossReferences":[{"database":"PubMed","id":"11060443"},{"database":"DOI","id":"10.1159/000015658"}],"title":"Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA.","publicationDate":"2000","journal":"Cytogenet. Cell Genet.","firstPage":"47","lastPage":"52","volume":"90"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"CI-5E5J0DL28HK2Q","citationType":"journal article","authors":["Carlquist M.","Joernvall H.","Forssmann W.-G.","Thulin L.","Johansson C.","Mutt V."],"title":"Human secretin is not identical to the porcine/bovine hormone.","publicationDate":"1985","journal":"IRCS Med. Sci.","firstPage":"217","lastPage":"218","volume":"13"},"referencePositions":["PROTEIN SEQUENCE OF 28-54","SUBCELLULAR LOCATION","AMIDATION AT VAL-54"]},{"referenceNumber":3,"citation":{"id":"25332973","citationType":"journal article","authors":["Afroze S.","Meng F.","Jensen K.","McDaniel K.","Rahal K.","Onori P.","Gaudio E.","Alpini G.","Glaser S.S."],"citationCrossReferences":[{"database":"PubMed","id":"25332973"},{"database":"DOI","id":"10.3978/j.issn.2305-5839.2012.12.01"}],"title":"The physiological roles of secretin and its receptor.","publicationDate":"2013","journal":"Ann. Transl. Med.","firstPage":"29","lastPage":"29","volume":"1"},"referencePositions":["REVIEW"]},{"referenceNumber":4,"citation":{"id":"30449620","citationType":"journal article","authors":["Li Y.","Schnabl K.","Gabler S.M.","Willershaeuser M.","Reber J.","Karlas A.","Laurila S.","Lahesmaa M.","U Din M.","Bast-Habersbrunner A.","Virtanen K.A.","Fromme T.","Bolze F.","O'Farrell L.S.","Alsina-Fernandez J.","Coskun T.","Ntziachristos V.","Nuutila P.","Klingenspor M."],"citationCrossReferences":[{"database":"PubMed","id":"30449620"},{"database":"DOI","id":"10.1016/j.cell.2018.10.016"}],"title":"Secretin-activated brown fat mediates prandial thermogenesis to induce satiation.","publicationDate":"2018","journal":"Cell","firstPage":"1561","lastPage":"1574","volume":"175"},"referencePositions":["FUNCTION","INDUCTION"]},{"referenceNumber":5,"citation":{"id":"33008599","citationType":"journal article","authors":["Fukuhara S.","Kobayashi K.","Kusakizako T.","Iida W.","Kato M.","Shihoya W.","Nureki O."],"citationCrossReferences":[{"database":"PubMed","id":"33008599"},{"database":"DOI","id":"10.1016/j.bbrc.2020.08.042"}],"title":"Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.","publicationDate":"2020","journal":"Biochem. Biophys. Res. Commun.","firstPage":"861","lastPage":"866","volume":"533"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) OF 28-54 IN COMPLEX WITH SCTR","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7D3S"}]},{"referenceNumber":6,"citation":{"id":"32811827","citationType":"journal article","authors":["Dong M.","Deganutti G.","Piper S.J.","Liang Y.L.","Khoshouei M.","Belousoff M.J.","Harikumar K.G.","Reynolds C.A.","Glukhova A.","Furness S.G.B.","Christopoulos A.","Danev R.","Wootten D.","Sexton P.M.","Miller L.J."],"citationCrossReferences":[{"database":"PubMed","id":"32811827"},{"database":"DOI","id":"10.1038/s41467-020-17791-4"}],"title":"Structure and dynamics of the active Gs-coupled human secretin receptor.","publicationDate":"2020","journal":"Nat. Commun.","firstPage":"4137","lastPage":"4137","volume":"11"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.30 ANGSTROMS) OF 28-54 IN COMPLEX WITH SCTR","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6WI9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6WZG"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF244355","properties":[{"key":"ProteinId","value":"AAG31443.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS7709.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_068739.1","properties":[{"key":"NucleotideSequenceId","value":"NM_021920.4"}]},{"database":"PDB","id":"6WI9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.30 A"},{"key":"Chains","value":"P=28-54"}]},{"database":"PDB","id":"6WZG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"P=28-54"}]},{"database":"PDB","id":"7D3S","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"P=28-54"}]},{"database":"PDBsum","id":"6WI9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WZG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7D3S","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21683","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21972","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30566","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112247","properties":[{"key":"Interactions","value":"6"}]},{"database":"CORUM","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P09683","properties":[{"key":"Number of interactors","value":"370"}]},{"database":"IntAct","id":"P09683","properties":[{"key":"Interactions","value":"4"}]},{"database":"STRING","id":"9606.ENSP00000176195","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB09532","properties":[{"key":"GenericName","value":"Secretin human"}]},{"database":"PhosphoSitePlus","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SCT","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"12231018","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000176195","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"9839","properties":[{"key":"antibodies","value":"199 antibodies from 32 providers"}]},{"database":"DNASU","id":"6343","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000176195.4","properties":[{"key":"ProteinId","value":"ENSP00000176195.3"},{"key":"GeneId","value":"ENSG00000070031.4"}]},{"database":"Ensembl","id":"ENST00000622382.2","properties":[{"key":"ProteinId","value":"ENSP00000483559.1"},{"key":"GeneId","value":"ENSG00000274473.2"}]},{"database":"GeneID","id":"6343","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6343","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000176195.4","properties":[{"key":"ProteinId","value":"ENSP00000176195.3"},{"key":"RefSeqNucleotideId","value":"NM_021920.4"},{"key":"RefSeqProteinId","value":"NP_068739.1"}]},{"database":"UCSC","id":"uc001lqo.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:10607","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA35017","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6343","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6343","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SCT","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10607","properties":[{"key":"GeneName","value":"SCT"}]},{"database":"HPA","id":"ENSG00000070031","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (intestine)"}]},{"database":"MIM","id":"182099","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000070031","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000070031","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502R8F0","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000002624","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1991937_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HAPFPWL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9417777at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P09683","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-418555","properties":[{"key":"PathwayName","value":"G alpha (s) signalling events"}]},{"database":"Reactome","id":"R-HSA-420092","properties":[{"key":"PathwayName","value":"Glucagon-type ligand receptors"}]},{"database":"SignaLink","id":"P09683","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000070031","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6343","properties":[{"key":"hits","value":"14 hits in 1145 CRISPR screens"}]},{"database":"GeneWiki","id":"Secretin","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6343","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P09683","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P09683","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"P09683","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000070031","properties":[{"key":"ExpressionPatterns","value":"Expressed in duodenum and 89 other cell types or tissues"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046659","properties":[{"key":"GoTerm","value":"F:digestive hormone activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001664","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor binding"},{"key":"GoEvidenceType","value":"IPI:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7612008"}]},{"database":"GO","id":"GO:0005179","properties":[{"key":"GoTerm","value":"F:hormone activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007189","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32811827"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0002024","properties":[{"key":"GoTerm","value":"P:diet induced thermogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048566","properties":[{"key":"GoTerm","value":"P:embryonic digestive tract development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0021766","properties":[{"key":"GoTerm","value":"P:hippocampus development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0009992","properties":[{"key":"GoTerm","value":"P:intracellular water homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1903640","properties":[{"key":"GoTerm","value":"P:negative regulation of gastrin-induced gastric acid secretion"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030157","properties":[{"key":"GoTerm","value":"P:pancreatic juice secretion"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11060443"}]},{"database":"GO","id":"GO:0141163","properties":[{"key":"GoTerm","value":"P:positive regulation of cAMP/PKA signal transduction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050996","properties":[{"key":"GoTerm","value":"P:positive regulation of lipid catabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0090187","properties":[{"key":"GoTerm","value":"P:positive regulation of pancreatic juice secretion"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0090274","properties":[{"key":"GoTerm","value":"P:positive regulation of somatostatin secretion"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032098","properties":[{"key":"GoTerm","value":"P:regulation of appetite"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048167","properties":[{"key":"GoTerm","value":"P:regulation of synaptic plasticity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031667","properties":[{"key":"GoTerm","value":"P:response to nutrient levels"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR000532","properties":[{"key":"EntryName","value":"Glucagon_GIP_secretin_VIP"}]},{"database":"InterPro","id":"IPR015675","properties":[{"key":"EntryName","value":"Prosecretin"}]},{"database":"PANTHER","id":"PTHR17378","properties":[{"key":"EntryName","value":"SECRETIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR17378:SF1","properties":[{"key":"EntryName","value":"SECRETIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00123","properties":[{"key":"EntryName","value":"Hormone_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00070","properties":[{"key":"EntryName","value":"GLUCA"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00260","properties":[{"key":"EntryName","value":"GLUCAGON"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPRPLLLLLLLLGGSAARPAPPRARRHSDGTFTSELSRLREGARLQRLLQGLVGKRSEQDAENSMAWTRLSAGLLCPSGSNMPILQAWMPLDGTWSPWLPPGPMVSEPAGAAAEGTLRPR","length":121,"molWeight":13016,"crc64":"44BDB4EFC0E161CF","md5":"D58CB411EB6CBCB11E622172717A10E4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":4,"SUBCELLULAR LOCATION":1,"INDUCTION":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Propeptide":2,"Peptide":1,"Modified residue":2,"Helix":1},"uniParcId":"UPI00001357C7"}}