{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P09429","secondaryAccessions":["A5D8W9","Q14321","Q5T7C3","Q6IBE1"],"uniProtkbId":"HMGB1_HUMAN","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":250,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"High mobility group protein B1"}},"alternativeNames":[{"fullName":{"value":"High mobility group protein 1"},"shortNames":[{"value":"HMG-1"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4983"}],"value":"HMGB1"},"synonyms":[{"value":"HMG1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P12682"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23303669"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25549101"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27362237"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33147444"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34743181"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23446148"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23519706"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23994764"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25048472"}],"value":"Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15014079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16143102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17803946"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19446504"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23063560"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19360789"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20123072"}],"value":"Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20819940"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21395369"}],"value":"In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12765338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15607795"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15944249"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18250463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18354232"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18631454"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19064698"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19264983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20547845"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21660935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22370717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22473704"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24474694"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24971542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25660311"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"}],"value":"In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33147444"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35239449"}],"value":"(Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22696656"}],"value":"(Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34922257"}],"value":"(Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34971702"}],"value":"(Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15014079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15841214"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17803946"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18160415"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18250463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19264983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19446504"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20547845"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20819940"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22370717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23063560"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23303669"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24474694"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34743181"}],"value":"Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin (PubMed:22370717). Associates with the TLR4:LY96 receptor complex (PubMed:20547845). Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 (By similarity). Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy (PubMed:20819940). Interacts with KPNA1; involved in nuclear import (PubMed:17114460). Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT (By similarity). Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53 (PubMed:15014079, PubMed:18160415, PubMed:18250463, PubMed:19446504, PubMed:23063560, PubMed:24474694). Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response (PubMed:19264983). Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity (PubMed:15841214). Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response (By similarity). Interacts with XPO1; mediating nuclear export (By similarity). Interacts with HTT (wild-type and mutant HTT with expanded polyglutamine repeat) (PubMed:23303669). Interacts with receptor RAGE/AGER (PubMed:34743181)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27362237"}],"value":"(Microbial infection) Interacts with adenovirus protein pVII; this interaction immobilizes HMGB1 on chromatin, thus preventing its release from cell and subsequent inflammation activation"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35239449"}],"value":"(Microbial infection) Interacts with SARS-CoV-2 ORF3A protein; the interaction promotes association of HMGB1 with BECN1, promoting reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22696656"}],"value":"(Microbial infection) Interacts with influenza A virus protein NP; this interaction promotes viral replication"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"Q15109","geneName":"AGER","intActId":"EBI-1646426"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"Q6RW13","geneName":"AGTRAP","intActId":"EBI-741181"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"Q14457","geneName":"BECN1","intActId":"EBI-949378"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"O95273","geneName":"CCNDBP1","intActId":"EBI-748961"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"Q00839","geneName":"HNRNPU","intActId":"EBI-351126"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"P08729","geneName":"KRT7","intActId":"EBI-297833"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"P43246","geneName":"MSH2","intActId":"EBI-355888"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"P09874","geneName":"PARP1","intActId":"EBI-355676"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"Q96T23","geneName":"RSF1","intActId":"EBI-926768"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"P23497","geneName":"SP100","intActId":"EBI-751145"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"P84103","geneName":"SRSF3","intActId":"EBI-372557"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"P04637","geneName":"TP53","intActId":"EBI-366083"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09429","intActId":"EBI-389432"},"interactantTwo":{"uniProtKBAccession":"Q96B54","geneName":"ZNF428","intActId":"EBI-9995882"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154118"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12231511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14532127"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15944249"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16855214"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18631454"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19811284"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20819940"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27362237"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20123072"}],"value":"In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284). Also released from apoptotic cells (PubMed:16855214, PubMed:18631454). Active secretion from a variety of immune and non-immune cells such as macrophages, monocytes, neutrophils, dendritic cells and natural killer cells in response to various stimuli such as LPS and cytokines involves a nonconventional secretory process via secretory lysosomes (PubMed:12231511, PubMed:14532127, PubMed:15944249). Secreted by plasma cells in response to LPS (By similarity). Found on the surface of activated platelets (PubMed:11154118). An increased chromatin association is observed when associated with the adenovirus protein pVII (PubMed:27362237)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12231511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20819940"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22696656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22869893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27362237"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33147444"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000305"}],"value":"Chromosome","id":"SL-0468"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154118"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12231511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20819940"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22869893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33147444"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34971702"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12231511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14532127"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15944249"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19811284"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22869893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33147444"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154118"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154118"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154118"}],"value":"Extracellular side","id":"SL-9911"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"}],"value":"Endosome","id":"SL-0101"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"}],"value":"Endoplasmic reticulum-Golgi intermediate compartment","id":"SL-0098"}}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35239449"}],"value":"(Microbial infection) SARS-COV-2 ORF3A promotes HMGB1 translocation from the nucleus to the cytoplasm where it is recruited by and colocalizes with ORF3A at the endoplasmic reticulum"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35239449"}],"value":"Endoplasmic reticulum","id":"SL-0095"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154118"}],"value":"Ubiquitous. Expressed in platelets (PubMed:11154118)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33147444"}],"value":"(Microbial infection) Protein levels increase upon infection by human coronavirus SARS-CoV-2"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12765338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20547845"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24474694"}],"value":"HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4 (PubMed:12765338, PubMed:20547845). However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance (PubMed:24474694)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23063560"}],"value":"The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins (PubMed:23063560)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"value":"Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion (PubMed:17114460)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22801494"}],"value":"Acetylated on multiple sites upon stimulation with LPS (PubMed:22801494). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion (By similarity). Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16962095"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19811284"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22869893"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24531895"}],"value":"Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"}],"value":"Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24474694"}],"value":"In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance (PubMed:24474694). Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"}],"value":"Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14695889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23040637"},{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19064698"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24220159"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26078984"}],"value":"Proposed to contribute to the pathogenesis of various chronic inflammatory and autoimmune diseases, and cancer. High serum levels are found in several inflammatory events including sepsis, rheumatoid arthritis, artherosclerosis chronic kidney disease, systemic lupus erythematosus (SLE). Seems to be implicated in other diseases characterized by cell death and damage, including diabetes and Alzheimer's disease. Its nucleosome-associated release during secondary necrosis may play a role in SLE (PubMed:19064698). During chemotherapy can mediate regrowth and metastasis of remaining cells in a AGER/RAGE-dependent manner (PubMed:23040637). Purified HMG box 1 acts as a specific antagonist to HGMB1 pro-inflammatory activities (PubMed:14695889)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the HMGB family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Inconsistent experimental results may reflect the use of inconsistently defined redox forms. A recombinant fully reduced form has been used in a number of experiments. However, the redox states of HMGB1 administered in vivo, may interconvert among each other. Purified HMGB1 by itself has only weak pro-inflammatory activity"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"High mobility group protein B1","featureId":"PRO_0000048526"},{"type":"DNA binding","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"HMG box 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00267"}]},{"type":"DNA binding","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"HMG box 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00267"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Sufficient for interaction with HAVCR2","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"}]},{"type":"Region","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"LPS binding (delipidated)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21660935"}]},{"type":"Region","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"LPS binding (Lipid A)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21660935"}]},{"type":"Region","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Cytokine-stimulating activity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12765338"}]},{"type":"Region","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Binding to AGER/RAGE","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"}]},{"type":"Region","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Nuclear localization signal (NLS) 1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"}]},{"type":"Motif","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Nuclear localization signal (NLS) 2","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"}]},{"type":"Compositional bias","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:28304"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}],"ligand":{"name":"heparin","id":"ChEBI:CHEBI:28304"}},{"type":"Site","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"Cleavage; by thrombin:thrombomodulin","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Site","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Cleavage; by CASP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24474694"}]},{"type":"Modified residue","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Cysteine sulfonic acid (-SO3H); alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"}]},{"type":"Modified residue","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"}]},{"type":"Modified residue","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Cysteine sulfonic acid (-SO3H); alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"}]},{"type":"Modified residue","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"}]},{"type":"Modified residue","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Cysteine sulfonic acid (-SO3H)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"}]},{"type":"Modified residue","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63158"}]},{"type":"Modified residue","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"ADP-ribosylserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28190768"}]},{"type":"Modified residue","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Modified residue","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10103"}]},{"type":"Disulfide bond","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"In disulfide HMGB1; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63159"}]},{"type":"Cross-link","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"}]},{"type":"Cross-link","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"}]},{"type":"Cross-link","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"}]},{"type":"Cross-link","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"}]},{"type":"Cross-link","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"}]},{"type":"Cross-link","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"}]},{"type":"Cross-link","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"}]},{"type":"Cross-link","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"}]},{"type":"Natural variant","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"in gastric-carcinoma cell line","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9036861"}],"featureId":"VAR_046451","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in gastric-carcinoma cell line","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9036861"}],"featureId":"VAR_046452","alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}],"featureId":"VAR_046453","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"in gastric-carcinoma cell line","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9036861"}],"featureId":"VAR_046454","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Greatly reduces phosphorylation, nuclear localization; when associated with A-39; A-42; A-46; A-53 and A-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Cytoplasmic localization (phosphorylation mimicking); when associated with E-39; E-42; E-46; E-53 and E-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-42; A-46; A-53 and A-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-42; E-46; E-53 and E-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-46; A-53 and A-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-46; E-53 and E-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-42; A-53 and A-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-42; E-53 and E-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-42; A-46 and A-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-42; E-46 and E-181.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Abolishes cleavage by CASP1 and impairs ability to antagonize apoptosis-induced immune tolerance.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24474694"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Inhibits oxidation-dependent inactivation of immunostimmulatory activity in apoptotic cells.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18631454"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-42; A-46 and A-53.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-42; E-46 and E-53.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"in Ref. 13; AAI41845","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in Ref. 8; CAG33144","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Beta strand","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2YRQ"}]},{"type":"Beta strand","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2YRQ"}]},{"type":"Helix","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9CG9"}]},{"type":"Helix","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9CG9"}]},{"type":"Beta strand","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CIK"}]},{"type":"Helix","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9CG9"}]},{"type":"Helix","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9CG9"}]},{"type":"Beta strand","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2YRQ"}]},{"type":"Helix","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CIK"}]},{"type":"Helix","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CIK"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2YRQ"}]},{"type":"Helix","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CIK"}]},{"type":"Helix","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2YRQ"}]},{"type":"Helix","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CIK"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"id":"KW-0013","category":"PTM","name":"ADP-ribosylation"},{"id":"KW-0072","category":"Biological process","name":"Autophagy"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0558","category":"PTM","name":"Oxidation"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"}],"references":[{"referenceNumber":1,"citation":{"id":"2922262","citationType":"journal article","authors":["Wen L.","Huang J.K.","Johnson B.H.","Reeck G.R."],"citationCrossReferences":[{"database":"PubMed","id":"2922262"},{"database":"DOI","id":"10.1093/nar/17.3.1197"}],"title":"A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.","publicationDate":"1989","journal":"Nucleic Acids Res.","firstPage":"1197","lastPage":"1214","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"8661151","citationType":"journal article","authors":["Ferrari S.","Finelli P.","Rocchi M.","Bianchi M.E."],"citationCrossReferences":[{"database":"PubMed","id":"8661151"},{"database":"DOI","id":"10.1006/geno.1996.0369"}],"title":"The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13.","publicationDate":"1996","journal":"Genomics","firstPage":"367","lastPage":"371","volume":"35"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"9036861","citationType":"journal article","authors":["Xiang Y.-Y.","Wang D.-Y.","Tanaka M.","Suzuki M.","Kiyokawa E.","Igarashi H.","Niato Y.","Shen Q.","Sugimura H."],"citationCrossReferences":[{"database":"PubMed","id":"9036861"},{"database":"DOI","id":"10.1002/(sici)1097-0215(19970220)74:1<1::aid-ijc1>3.0.co;2-6"}],"title":"Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.","publicationDate":"1997","journal":"Int. J. Cancer","firstPage":"1","lastPage":"6","volume":"74"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","VARIANTS ARG-11; GLU-149 AND GLY-190"]},{"referenceNumber":4,"citation":{"id":"17610420","citationType":"journal article","authors":["Kornblit B.","Munthe-Fog L.","Petersen S.","Madsen H.","Vindeloev L.","Garred P."],"citationCrossReferences":[{"database":"PubMed","id":"17610420"},{"database":"DOI","id":"10.1111/j.1399-0039.2007.00854.x"}],"title":"The genetic variation of the human HMGB1 gene.","publicationDate":"2007","journal":"Tissue Antigens","firstPage":"151","lastPage":"156","volume":"70"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-6KC976N1UG2BE","citationType":"submission","authors":["He F.T.","Yang Z.H.","Ji Q.","Li R.","Peng J.","Jiang Y.","Zhong X."],"publicationDate":"SEP-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":6,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Cerebellum","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Small intestine","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"CI-D49P6QQO8F5LU","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":9,"citation":{"id":"CI-54UTT6AFSFO1R","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"OCT-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":10,"citation":{"id":"CI-8451548LO0DBJ","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"JUL-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT GLN-156"]},{"referenceNumber":11,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.R.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.F.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":12,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":13,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Cervix","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"9150946","citationType":"journal article","authors":["Rasmussen R.K.","Ji H.","Eddes J.S.","Moritz R.L.","Reid G.E.","Simpson R.J.","Dorow D.S."],"citationCrossReferences":[{"database":"PubMed","id":"9150946"},{"database":"DOI","id":"10.1002/elps.1150180342"}],"title":"Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.","publicationDate":"1997","journal":"Electrophoresis","firstPage":"588","lastPage":"598","volume":"18"},"referencePositions":["PROTEIN SEQUENCE OF 58-65 AND 113-127"],"referenceComments":[{"value":"Mammary carcinoma","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"11154118","citationType":"journal article","authors":["Rouhiainen A.","Imai S.","Rauvala H.","Parkkinen J."],"citationCrossReferences":[{"database":"PubMed","id":"11154118"},{"database":"DOI","id":"10.1055/s-0037-1614175"}],"title":"Occurrence of amphoterin (HMG1) as an endogenous protein of human platelets that is exported to the cell surface upon platelet activation.","publicationDate":"2000","journal":"Thromb. Haemost.","firstPage":"1087","lastPage":"1094","volume":"84"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":16,"citation":{"id":"12231511","citationType":"journal article","authors":["Gardella S.","Andrei C.","Ferrera D.","Lotti L.V.","Torrisi M.R.","Bianchi M.E.","Rubartelli A."],"citationCrossReferences":[{"database":"PubMed","id":"12231511"},{"database":"DOI","id":"10.1093/embo-reports/kvf198"}],"title":"The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway.","publicationDate":"2002","journal":"EMBO Rep.","firstPage":"995","lastPage":"1001","volume":"3"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":17,"citation":{"id":"14532127","citationType":"journal article","authors":["Bonaldi T.","Talamo F.","Scaffidi P.","Ferrera D.","Porto A.","Bachi A.","Rubartelli A.","Agresti A.","Bianchi M.E."],"citationCrossReferences":[{"database":"PubMed","id":"14532127"},{"database":"DOI","id":"10.1093/emboj/cdg516"}],"title":"Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion.","publicationDate":"2003","journal":"EMBO J.","firstPage":"5551","lastPage":"5560","volume":"22"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":18,"citation":{"id":"12765338","citationType":"journal article","authors":["Li J.","Kokkola R.","Tabibzadeh S.","Yang R.","Ochani M.","Qiang X.","Harris H.E.","Czura C.J.","Wang H.","Ulloa L.","Wang H.","Warren H.S.","Moldawer L.L.","Fink M.P.","Andersson U.","Tracey K.J.","Yang H."],"citationCrossReferences":[{"database":"PubMed","id":"12765338"},{"database":"DOI","id":"10.1007/bf03402105"}],"title":"Structural basis for the proinflammatory cytokine activity of high mobility group box 1.","publicationDate":"2003","journal":"Mol. Med.","firstPage":"37","lastPage":"45","volume":"9"},"referencePositions":["FUNCTION","DOMAIN"]},{"referenceNumber":19,"citation":{"id":"15014079","citationType":"journal article","authors":["Yuan F.","Gu L.","Guo S.","Wang C.","Li G.M."],"citationCrossReferences":[{"database":"PubMed","id":"15014079"},{"database":"DOI","id":"10.1074/jbc.m401931200"}],"title":"Evidence for involvement of HMGB1 protein in human DNA mismatch repair.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"20935","lastPage":"20940","volume":"279"},"referencePositions":["FUNCTION","INTERACTION WITH MSH2"]},{"referenceNumber":20,"citation":{"id":"14695889","citationType":"journal article","authors":["Yang H.","Ochani M.","Li J.","Qiang X.","Tanovic M.","Harris H.E.","Susarla S.M.","Ulloa L.","Wang H.","DiRaimo R.","Czura C.J.","Wang H.","Roth J.","Warren H.S.","Fink M.P.","Fenton M.J.","Andersson U.","Tracey K.J."],"citationCrossReferences":[{"database":"PubMed","id":"14695889"},{"database":"DOI","id":"10.1073/pnas.2434651100"}],"title":"Reversing established sepsis with antagonists of endogenous high-mobility group box 1.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"296","lastPage":"301","volume":"101"},"referencePositions":["INVOLVEMENT IN INFLAMMATORY DISEASES"]},{"referenceNumber":21,"citation":{"id":"16143102","citationType":"journal article","authors":["Zhang Y.","Yuan F.","Presnell S.R.","Tian K.","Gao Y.","Tomkinson A.E.","Gu L.","Li G.-M."],"citationCrossReferences":[{"database":"PubMed","id":"16143102"},{"database":"DOI","id":"10.1016/j.cell.2005.06.027"}],"title":"Reconstitution of 5'-directed human mismatch repair in a purified system.","publicationDate":"2005","journal":"Cell","firstPage":"693","lastPage":"705","volume":"122"},"referencePositions":["FUNCTION"]},{"referenceNumber":22,"citation":{"id":"15841214","citationType":"journal article","authors":["Abeyama K.","Stern D.M.","Ito Y.","Kawahara K.","Yoshimoto Y.","Tanaka M.","Uchimura T.","Ida N.","Yamazaki Y.","Yamada S.","Yamamoto Y.","Yamamoto H.","Iino S.","Taniguchi N.","Maruyama I."],"citationCrossReferences":[{"database":"PubMed","id":"15841214"},{"database":"DOI","id":"10.1172/jci22782"}],"title":"The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism.","publicationDate":"2005","journal":"J. Clin. Invest.","firstPage":"1267","lastPage":"1274","volume":"115"},"referencePositions":["INTERACTION WITH THBD"]},{"referenceNumber":23,"citation":{"id":"15944249","citationType":"journal article","authors":["Dumitriu I.E.","Baruah P.","Valentinis B.","Voll R.E.","Herrmann M.","Nawroth P.P.","Arnold B.","Bianchi M.E.","Manfredi A.A.","Rovere-Querini P."],"citationCrossReferences":[{"database":"PubMed","id":"15944249"},{"database":"DOI","id":"10.4049/jimmunol.174.12.7506"}],"title":"Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products.","publicationDate":"2005","journal":"J. Immunol.","firstPage":"7506","lastPage":"7515","volume":"174"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":24,"citation":{"id":"15607795","citationType":"journal article","authors":["DeMarco R.A.","Fink M.P.","Lotze M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15607795"},{"database":"DOI","id":"10.1016/j.molimm.2004.07.023"}],"title":"Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1.","publicationDate":"2005","journal":"Mol. Immunol.","firstPage":"433","lastPage":"444","volume":"42"},"referencePositions":["FUNCTION"]},{"referenceNumber":25,"citation":{"id":"16855214","citationType":"journal article","authors":["Bell C.W.","Jiang W.","Reich C.F.","Pisetsky D.S."],"citationCrossReferences":[{"database":"PubMed","id":"16855214"},{"database":"DOI","id":"10.1152/ajpcell.00616.2005"}],"title":"The extracellular release of HMGB1 during apoptotic cell death.","publicationDate":"2006","journal":"Am. J. Physiol.","firstPage":"C1318","lastPage":"C1325","volume":"291"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":26,"citation":{"id":"16962095","citationType":"journal article","authors":["Hoppe G.","Talcott K.E.","Bhattacharya S.K.","Crabb J.W.","Sears J.E."],"citationCrossReferences":[{"database":"PubMed","id":"16962095"},{"database":"DOI","id":"10.1016/j.yexcr.2006.07.020"}],"title":"Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1.","publicationDate":"2006","journal":"Exp. Cell Res.","firstPage":"3526","lastPage":"3538","volume":"312"},"referencePositions":["DISULFIDE BRIDGE","REDOX FORMS"]},{"referenceNumber":27,"citation":{"id":"17114460","citationType":"journal article","authors":["Youn J.H.","Shin J.S."],"citationCrossReferences":[{"database":"PubMed","id":"17114460"},{"database":"DOI","id":"10.4049/jimmunol.177.11.7889"}],"title":"Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion.","publicationDate":"2006","journal":"J. Immunol.","firstPage":"7889","lastPage":"7897","volume":"177"},"referencePositions":["PHOSPHORYLATION","MUTAGENESIS OF SER-35; SER-39; SER-42; SER-46; SER-53 AND SER-181","SUBCELLULAR LOCATION","INTERACTION WITH KPNA1"]},{"referenceNumber":28,"citation":{"id":"18631454","citationType":"journal article","authors":["Kazama H.","Ricci J.E.","Herndon J.M.","Hoppe G.","Green D.R.","Ferguson T.A."],"citationCrossReferences":[{"database":"PubMed","id":"18631454"},{"database":"DOI","id":"10.1016/j.immuni.2008.05.013"}],"title":"Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein.","publicationDate":"2008","journal":"Immunity","firstPage":"21","lastPage":"32","volume":"29"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","MUTAGENESIS OF CYS-106"]},{"referenceNumber":29,"citation":{"id":"17803946","citationType":"journal article","authors":["Prasad R.","Liu Y.","Deterding L.J.","Poltoratsky V.P.","Kedar P.S.","Horton J.K.","Kanno S.","Asagoshi K.","Hou E.W.","Khodyreva S.N.","Lavrik O.I.","Tomer K.B.","Yasui A.","Wilson S.H."],"citationCrossReferences":[{"database":"PubMed","id":"17803946"},{"database":"DOI","id":"10.1016/j.molcel.2007.06.029"}],"title":"HMGB1 is a cofactor in mammalian base excision repair.","publicationDate":"2007","journal":"Mol. Cell","firstPage":"829","lastPage":"841","volume":"27"},"referencePositions":["FUNCTION"]},{"referenceNumber":30,"citation":{"id":"19064698","citationType":"journal article","authors":["Urbonaviciute V.","Furnrohr B.G.","Meister S.","Munoz L.","Heyder P.","De Marchis F.","Bianchi M.E.","Kirschning C.","Wagner H.","Manfredi A.A.","Kalden J.R.","Schett G.","Rovere-Querini P.","Herrmann M.","Voll R.E."],"citationCrossReferences":[{"database":"PubMed","id":"19064698"},{"database":"DOI","id":"10.1084/jem.20081165"}],"title":"Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE.","publicationDate":"2008","journal":"J. Exp. Med.","firstPage":"3007","lastPage":"3018","volume":"205"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","INVOLVEMENT IN AUTOIMMUNE DISEASES"]},{"referenceNumber":31,"citation":{"id":"18250463","citationType":"journal article","authors":["Sha Y.","Zmijewski J.","Xu Z.","Abraham E."],"citationCrossReferences":[{"database":"PubMed","id":"18250463"},{"database":"DOI","id":"10.4049/jimmunol.180.4.2531"}],"title":"HMGB1 develops enhanced proinflammatory activity by binding to cytokines.","publicationDate":"2008","journal":"J. Immunol.","firstPage":"2531","lastPage":"2537","volume":"180"},"referencePositions":["FUNCTION","INTERACTION WITH IL1B"]},{"referenceNumber":32,"citation":{"id":"18354232","citationType":"journal article","authors":["Youn J.H.","Oh Y.J.","Kim E.S.","Choi J.E.","Shin J.S."],"citationCrossReferences":[{"database":"PubMed","id":"18354232"},{"database":"DOI","id":"10.4049/jimmunol.180.7.5067"}],"title":"High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes.","publicationDate":"2008","journal":"J. Immunol.","firstPage":"5067","lastPage":"5074","volume":"180"},"referencePositions":["FUNCTION"]},{"referenceNumber":33,"citation":{"id":"18160415","citationType":"journal article","authors":["Yu M.","Wang J.","Li W.","Yuan Y.Z.","Li C.Y.","Qian X.H.","Xu W.X.","Zhan Y.Q.","Yang X.M."],"citationCrossReferences":[{"database":"PubMed","id":"18160415"},{"database":"DOI","id":"10.1093/nar/gkm1131"}],"title":"Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha.","publicationDate":"2008","journal":"Nucleic Acids Res.","firstPage":"1209","lastPage":"1219","volume":"36"},"referencePositions":["INTERACTION WITH HNF1A"]},{"referenceNumber":34,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-100","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":35,"citation":{"id":"19811284","citationType":"journal article","authors":["Urbonaviciute V.","Meister S.","Furnrohr B.G.","Frey B.","Guckel E.","Schett G.","Herrmann M.","Voll R.E."],"citationCrossReferences":[{"database":"PubMed","id":"19811284"},{"database":"DOI","id":"10.1080/08916930902831803"}],"title":"Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis.","publicationDate":"2009","journal":"Autoimmunity","firstPage":"305","lastPage":"307","volume":"42"},"referencePositions":["REDOX FORMS","SUBCELLULAR LOCATION"]},{"referenceNumber":36,"citation":{"id":"19446504","citationType":"journal article","authors":["Lange S.S.","Reddy M.C.","Vasquez K.M."],"citationCrossReferences":[{"database":"PubMed","id":"19446504"},{"database":"DOI","id":"10.1016/j.dnarep.2009.04.001"}],"title":"Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.","publicationDate":"2009","journal":"DNA Repair","firstPage":"865","lastPage":"872","volume":"8"},"referencePositions":["FUNCTION","INTERACTION WITH XPA AND XPC"]},{"referenceNumber":37,"citation":{"id":"19360789","citationType":"journal article","authors":["Lange S.S.","Vasquez K.M."],"citationCrossReferences":[{"database":"PubMed","id":"19360789"},{"database":"DOI","id":"10.1002/mc.20544"}],"title":"HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic.","publicationDate":"2009","journal":"Mol. Carcinog.","firstPage":"571","lastPage":"580","volume":"48"},"referencePositions":["REVIEW ON FUNCTION RELATED TO DNA REPAIR"]},{"referenceNumber":38,"citation":{"id":"19264983","citationType":"journal article","authors":["Chen G.Y.","Tang J.","Zheng P.","Liu Y."],"citationCrossReferences":[{"database":"PubMed","id":"19264983"},{"database":"DOI","id":"10.1126/science.1168988"}],"title":"CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.","publicationDate":"2009","journal":"Science","firstPage":"1722","lastPage":"1725","volume":"323"},"referencePositions":["FUNCTION","INTERACTION WITH CD24","LIGAND FOR CD24:SIGLEC10 RECEPTOR COMPLEX"]},{"referenceNumber":39,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-30","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":40,"citation":{"id":"20123072","citationType":"journal article","authors":["Stros M."],"citationCrossReferences":[{"database":"PubMed","id":"20123072"},{"database":"DOI","id":"10.1016/j.bbagrm.2009.09.008"}],"title":"HMGB proteins: interactions with DNA and chromatin.","publicationDate":"2010","journal":"Biochim. Biophys. Acta","firstPage":"101","lastPage":"113","volume":"1799"},"referencePositions":["REVIEW ON FUNCTION RELATED TO DNA-BINDING"]},{"referenceNumber":41,"citation":{"id":"20819940","citationType":"journal article","authors":["Tang D.","Kang R.","Livesey K.M.","Cheh C.W.","Farkas A.","Loughran P.","Hoppe G.","Bianchi M.E.","Tracey K.J.","Zeh H.J. III","Lotze M.T."],"citationCrossReferences":[{"database":"PubMed","id":"20819940"},{"database":"DOI","id":"10.1083/jcb.200911078"}],"title":"Endogenous HMGB1 regulates autophagy.","publicationDate":"2010","journal":"J. Cell Biol.","firstPage":"881","lastPage":"892","volume":"190"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH BECN1"]},{"referenceNumber":42,"citation":{"id":"20547845","citationType":"journal article","authors":["Yang H.","Hreggvidsdottir H.S.","Palmblad K.","Wang H.","Ochani M.","Li J.","Lu B.","Chavan S.","Rosas-Ballina M.","Al-Abed Y.","Akira S.","Bierhaus A.","Erlandsson-Harris H.","Andersson U.","Tracey K.J."],"citationCrossReferences":[{"database":"PubMed","id":"20547845"},{"database":"DOI","id":"10.1073/pnas.1003893107"}],"title":"A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11942","lastPage":"11947","volume":"107"},"referencePositions":["FUNCTION","LIGAND FOR TLR4:LY96 RECEPTOR COMPLEX","DOMAIN"]},{"referenceNumber":43,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":44,"citation":{"id":"21395369","citationType":"journal article","authors":["Tang D.","Kang R.","Livesey K.M.","Zeh H.J.","Lotze M.T."],"citationCrossReferences":[{"database":"PubMed","id":"21395369"},{"database":"DOI","id":"10.1089/ars.2010.3666"}],"title":"High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress.","publicationDate":"2011","journal":"Antioxid. Redox Signal.","firstPage":"2185","lastPage":"2195","volume":"15"},"referencePositions":["FUNCTION"]},{"referenceNumber":45,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":46,"citation":{"id":"21660935","citationType":"journal article","authors":["Youn J.H.","Kwak M.S.","Wu J.","Kim E.S.","Ji Y.","Min H.J.","Yoo J.H.","Choi J.E.","Cho H.S.","Shin J.S."],"citationCrossReferences":[{"database":"PubMed","id":"21660935"},{"database":"DOI","id":"10.1002/eji.201141391"}],"title":"Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model.","publicationDate":"2011","journal":"Eur. J. Immunol.","firstPage":"2753","lastPage":"2762","volume":"41"},"referencePositions":["LPS-BINDING"]},{"referenceNumber":47,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":48,"citation":{"id":"22696656","citationType":"journal article","authors":["Moisy D.","Avilov S.V.","Jacob Y.","Laoide B.M.","Ge X.","Baudin F.","Naffakh N.","Jestin J.L."],"citationCrossReferences":[{"database":"PubMed","id":"22696656"},{"database":"DOI","id":"10.1128/jvi.00789-12"}],"title":"HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication.","publicationDate":"2012","journal":"J. Virol.","firstPage":"9122","lastPage":"9133","volume":"86"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH INFLUENZA A VIRUS PROTEIN NP (MICROBIAL INFECTION)","SUBCELLULAR LOCATION"]},{"referenceNumber":49,"citation":{"id":"22473704","citationType":"journal article","authors":["Wild C.A.","Bergmann C.","Fritz G.","Schuler P.","Hoffmann T.K.","Lotfi R.","Westendorf A.","Brandau S.","Lang S."],"citationCrossReferences":[{"database":"PubMed","id":"22473704"},{"database":"DOI","id":"10.1093/intimm/dxs051"}],"title":"HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells.","publicationDate":"2012","journal":"Int. Immunol.","firstPage":"485","lastPage":"494","volume":"24"},"referencePositions":["FUNCTION"]},{"referenceNumber":50,"citation":{"id":"22370717","citationType":"journal article","authors":["Schiraldi M.","Raucci A.","Munoz L.M.","Livoti E.","Celona B.","Venereau E.","Apuzzo T.","De Marchis F.","Pedotti M.","Bachi A.","Thelen M.","Varani L.","Mellado M.","Proudfoot A.","Bianchi M.E.","Uguccioni M."],"citationCrossReferences":[{"database":"PubMed","id":"22370717"},{"database":"DOI","id":"10.1084/jem.20111739"}],"title":"HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4.","publicationDate":"2012","journal":"J. Exp. Med.","firstPage":"551","lastPage":"563","volume":"209"},"referencePositions":["FUNCTION","INTERACTION WITH CXCL12"]},{"referenceNumber":51,"citation":{"id":"22869893","citationType":"journal article","authors":["Venereau E.","Casalgrandi M.","Schiraldi M.","Antoine D.J.","Cattaneo A.","De Marchis F.","Liu J.","Antonelli A.","Preti A.","Raeli L.","Shams S.S.","Yang H.","Varani L.","Andersson U.","Tracey K.J.","Bachi A.","Uguccioni M.","Bianchi M.E."],"citationCrossReferences":[{"database":"PubMed","id":"22869893"},{"database":"DOI","id":"10.1084/jem.20120189"}],"title":"Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release.","publicationDate":"2012","journal":"J. Exp. Med.","firstPage":"1519","lastPage":"1528","volume":"209"},"referencePositions":["REDOX FORMS","SUBCELLULAR LOCATION"]},{"referenceNumber":52,"citation":{"id":"22801494","citationType":"journal article","authors":["Lu B.","Nakamura T.","Inouye K.","Li J.","Tang Y.","Lundbaeck P.","Valdes-Ferrer S.I.","Olofsson P.S.","Kalb T.","Roth J.","Zou Y.","Erlandsson-Harris H.","Yang H.","Ting J.P.","Wang H.","Andersson U.","Antoine D.J.","Chavan S.S.","Hotamisligil G.S.","Tracey K.J."],"citationCrossReferences":[{"database":"PubMed","id":"22801494"},{"database":"DOI","id":"10.1038/nature11290"}],"title":"Novel role of PKR in inflammasome activation and HMGB1 release.","publicationDate":"2012","journal":"Nature","firstPage":"670","lastPage":"674","volume":"488"},"referencePositions":["ACETYLATION"]},{"referenceNumber":53,"citation":{"id":"23040637","citationType":"journal article","authors":["Luo Y.","Chihara Y.","Fujimoto K.","Sasahira T.","Kuwada M.","Fujiwara R.","Fujii K.","Ohmori H.","Kuniyasu H."],"citationCrossReferences":[{"database":"PubMed","id":"23040637"},{"database":"DOI","id":"10.1016/j.ejca.2012.09.016"}],"title":"High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy.","publicationDate":"2013","journal":"Eur. J. Cancer","firstPage":"741","lastPage":"751","volume":"49"},"referencePositions":["INVOLVEMENT IN CANCER THERAPY"]},{"referenceNumber":54,"citation":{"id":"23519706","citationType":"journal article","authors":["Li G.","Liang X.","Lotze M.T."],"citationCrossReferences":[{"database":"PubMed","id":"23519706"},{"database":"DOI","id":"10.3389/fimmu.2013.00068"}],"title":"HMGB1: The central cytokine for all lymphoid cells.","publicationDate":"2013","journal":"Front. Immunol.","firstPage":"68","lastPage":"68","volume":"4"},"referencePositions":["REVIEW ON FUNCTION RELATED TO ADAPTIVE IMMUNITY"]},{"referenceNumber":55,"citation":{"id":"23303669","citationType":"journal article","authors":["Min H.J.","Ko E.A.","Wu J.","Kim E.S.","Kwon M.K.","Kwak M.S.","Choi J.E.","Lee J.E.","Shin J.S."],"citationCrossReferences":[{"database":"PubMed","id":"23303669"},{"database":"DOI","id":"10.4049/jimmunol.1202472"}],"title":"Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates.","publicationDate":"2013","journal":"J. Immunol.","firstPage":"1797","lastPage":"1806","volume":"190"},"referencePositions":["FUNCTION","INTERACTION WITH HTT"]},{"referenceNumber":56,"citation":{"id":"23446148","citationType":"journal article","authors":["Yang H.","Antoine D.J.","Andersson U.","Tracey K.J."],"citationCrossReferences":[{"database":"PubMed","id":"23446148"},{"database":"DOI","id":"10.1189/jlb.1212662"}],"title":"The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis.","publicationDate":"2013","journal":"J. Leukoc. Biol.","firstPage":"865","lastPage":"873","volume":"93"},"referencePositions":["REVIEW ON FUNCTION RELATED TO INFLAMMATION"]},{"referenceNumber":57,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":58,"citation":{"id":"23994764","citationType":"journal article","authors":["Li G.","Tang D.","Lotze M.T."],"citationCrossReferences":[{"database":"PubMed","id":"23994764"},{"database":"DOI","id":"10.1016/j.semcancer.2013.08.002"}],"title":"Menage a Trois in stress: DAMPs, redox and autophagy.","publicationDate":"2013","journal":"Semin. Cancer Biol.","firstPage":"380","lastPage":"390","volume":"23"},"referencePositions":["REVIEW"]},{"referenceNumber":59,"citation":{"id":"24971542","citationType":"journal article","authors":["Liu L.","Yang M.","Kang R.","Dai Y.","Yu Y.","Gao F.","Wang H.","Sun X.","Li X.","Li J.","Wang H.","Cao L.","Tang D."],"citationCrossReferences":[{"database":"PubMed","id":"24971542"},{"database":"DOI","id":"10.1016/j.bbrc.2014.06.074"}],"title":"HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE.","publicationDate":"2014","journal":"Biochem. Biophys. Res. Commun.","firstPage":"851","lastPage":"856","volume":"450"},"referencePositions":["FUNCTION"]},{"referenceNumber":60,"citation":{"id":"24474694","citationType":"journal article","authors":["LeBlanc P.M.","Doggett T.A.","Choi J.","Hancock M.A.","Durocher Y.","Frank F.","Nagar B.","Ferguson T.A.","Saleh M."],"citationCrossReferences":[{"database":"PubMed","id":"24474694"},{"database":"DOI","id":"10.1074/jbc.m113.541474"}],"title":"An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor.","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"7777","lastPage":"7786","volume":"289"},"referencePositions":["FUNCTION","MUTAGENESIS OF ASP-67","INTERACTION WITH AGER","DOMAIN","PROTEOLYTIC CLEAVAGE"]},{"referenceNumber":61,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":62,"citation":{"id":"24531895","citationType":"journal article","authors":["Antoine D.J.","Harris H.E.","Andersson U.","Tracey K.J.","Bianchi M.E."],"citationCrossReferences":[{"database":"PubMed","id":"24531895"},{"database":"DOI","id":"10.2119/molmed.2014.00022"}],"title":"A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.","publicationDate":"2014","journal":"Mol. Med.","firstPage":"135","lastPage":"137","volume":"20"},"referencePositions":["NOMENCLATURE OF REDOX FORMS"]},{"referenceNumber":63,"citation":{"id":"24220159","citationType":"journal article","authors":["Musumeci D.","Roviello G.N.","Montesarchio D."],"citationCrossReferences":[{"database":"PubMed","id":"24220159"},{"database":"DOI","id":"10.1016/j.pharmthera.2013.11.001"}],"title":"An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies.","publicationDate":"2014","journal":"Pharmacol. Ther.","firstPage":"347","lastPage":"357","volume":"141"},"referencePositions":["REVIEW ON INVOLVEMENT IN DISEASES AND THERAPEUTIC TARGET"]},{"referenceNumber":64,"citation":{"id":"25549101","citationType":"journal article","authors":["Lee L.C.","Chen C.M.","Wang P.R.","Su M.T.","Lee-Chen G.J.","Chang C.Y."],"citationCrossReferences":[{"database":"PubMed","id":"25549101"},{"database":"DOI","id":"10.1371/journal.pone.0115809"}],"title":"Role of high mobility group box 1 (HMGB1) in SCA17 pathogenesis.","publicationDate":"2014","journal":"PLoS ONE","firstPage":"E115809","lastPage":"E115809","volume":"9"},"referencePositions":["FUNCTION"]},{"referenceNumber":65,"citation":{"id":"25048472","citationType":"journal article","authors":["Lee S.A.","Kwak M.S.","Kim S.","Shin J.S."],"citationCrossReferences":[{"database":"PubMed","id":"25048472"},{"database":"DOI","id":"10.3349/ymj.2014.55.5.1165"}],"title":"The role of high mobility group box 1 in innate immunity.","publicationDate":"2014","journal":"Yonsei Med. J.","firstPage":"1165","lastPage":"1176","volume":"55"},"referencePositions":["REVIEW ON FUNCTION RELATED TO INNATE IMMUNITY"]},{"referenceNumber":66,"citation":{"id":"26078984","citationType":"journal article","authors":["Lu M.","Yu S.","Xu W.","Gao B.","Xiong S."],"citationCrossReferences":[{"database":"PubMed","id":"26078984"},{"database":"DOI","id":"10.1155/2015/946748"}],"title":"HMGB1 promotes systemic lupus erythematosus by enhancing macrophage inflammatory response.","publicationDate":"2015","journal":"J. Immunol. Res.","firstPage":"946748","lastPage":"946748","volume":"2015"},"referencePositions":["INVOLVEMENT AUTOIMMUNE DISEASES"]},{"referenceNumber":67,"citation":{"id":"25660311","citationType":"journal article","authors":["Kwak M.S.","Lim M.","Lee Y.J.","Lee H.S.","Kim Y.H.","Youn J.H.","Choi J.E.","Shin J.S."],"citationCrossReferences":[{"database":"PubMed","id":"25660311"},{"database":"DOI","id":"10.1159/000369972"}],"title":"HMGB1 binds to lipoteichoic acid and enhances TNF-alpha and IL-6 production through HMGB1-mediated transfer of lipoteichoic acid to CD14 and TLR2.","publicationDate":"2015","journal":"J. Innate Immun.","firstPage":"405","lastPage":"416","volume":"7"},"referencePositions":["FUNCTION"]},{"referenceNumber":68,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":69,"citation":{"id":"27362237","citationType":"journal article","authors":["Avgousti D.C.","Herrmann C.","Kulej K.","Pancholi N.J.","Sekulic N.","Petrescu J.","Molden R.C.","Blumenthal D.","Paris A.J.","Reyes E.D.","Ostapchuk P.","Hearing P.","Seeholzer S.H.","Worthen G.S.","Black B.E.","Garcia B.A.","Weitzman M.D."],"citationCrossReferences":[{"database":"PubMed","id":"27362237"},{"database":"DOI","id":"10.1038/nature18317"}],"title":"A core viral protein binds host nucleosomes to sequester immune danger signals.","publicationDate":"2016","journal":"Nature","firstPage":"173","lastPage":"177","volume":"535"},"referencePositions":["FUNCTION","INTERACTION WITH ADENOVIRUS PROTEIN PVII (MICROBIAL INFECTION)","SUBCELLULAR LOCATION"]},{"referenceNumber":70,"citation":{"id":"28190768","citationType":"journal article","authors":["Bonfiglio J.J.","Fontana P.","Zhang Q.","Colby T.","Gibbs-Seymour I.","Atanassov I.","Bartlett E.","Zaja R.","Ahel I.","Matic I."],"citationCrossReferences":[{"database":"PubMed","id":"28190768"},{"database":"DOI","id":"10.1016/j.molcel.2017.01.003"}],"title":"Serine ADP-ribosylation depends on HPF1.","publicationDate":"2017","journal":"Mol. Cell","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["ADP-RIBOSYLATION AT SER-181"]},{"referenceNumber":71,"citation":{"id":"29618516","citationType":"journal article","authors":["Willis W.L.","Wang L.","Wada T.T.","Gardner M.","Abdouni O.","Hampton J.","Valiente G.","Young N.","Ardoin S.","Agarwal S.","Freitas M.A.","Wu L.C.","Jarjour W.N."],"citationCrossReferences":[{"database":"PubMed","id":"29618516"},{"database":"DOI","id":"10.1074/jbc.ra117.001078"}],"title":"The proinflammatory protein HMGB1 is a substrate of transglutaminase-2 and forms high-molecular weight complexes with autoantigens.","publicationDate":"2018","journal":"J. Biol. Chem.","firstPage":"8394","lastPage":"8409","volume":"293"},"referencePositions":["SUBCELLULAR LOCATION","TRANSGLUTAMINATION AT LYS-28; LYS-43; LYS-44; LYS-68; LYS-177; LYS-180; LYS-182; LYS-183 AND LYS-184"]},{"referenceNumber":72,"citation":{"id":"33147444","citationType":"journal article","authors":["Wei J.","Alfajaro M.M.","DeWeirdt P.C.","Hanna R.E.","Lu-Culligan W.J.","Cai W.L.","Strine M.S.","Zhang S.M.","Graziano V.R.","Schmitz C.O.","Chen J.S.","Mankowski M.C.","Filler R.B.","Ravindra N.G.","Gasque V.","de Miguel F.J.","Patil A.","Chen H.","Oguntuyo K.Y.","Abriola L.","Surovtseva Y.V.","Orchard R.C.","Lee B.","Lindenbach B.D.","Politi K.","van Dijk D.","Kadoch C.","Simon M.D.","Yan Q.","Doench J.G.","Wilen C.B."],"citationCrossReferences":[{"database":"PubMed","id":"33147444"},{"database":"DOI","id":"10.1016/j.cell.2020.10.028"}],"title":"Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.","publicationDate":"2021","journal":"Cell","firstPage":"76","lastPage":"91.e13","volume":"184"},"referencePositions":["FUNCTION","FUNCTION (MICROBIAL INFECTION)","SUBCELLULAR LOCATION","INDUCTION BY SARS-COV2 (MICROBIAL INFECTION)"]},{"referenceNumber":73,"citation":{"id":"34743181","citationType":"journal article","authors":["Wang G.","Jin S.","Huang W.","Li Y.","Wang J.","Ling X.","Huang Y.","Hu Y.","Li C.","Meng Y.","Li X."],"citationCrossReferences":[{"database":"PubMed","id":"34743181"},{"database":"DOI","id":"10.1038/s41420-021-00729-0"}],"title":"LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.","publicationDate":"2021","journal":"Cell. Death. Discov.","firstPage":"337","lastPage":"337","volume":"7"},"referencePositions":["FUNCTION","INTERACTION WITH AGER"]},{"referenceNumber":74,"citation":{"id":"34922257","citationType":"journal article","authors":["Reinhart N.M.","Akinyemi I.A.","Frey T.R.","Xu H.","Agudelo C.","Brathwaite J.","Burton E.M.","Burgula S.","McIntosh M.T.","Bhaduri-McIntosh S."],"citationCrossReferences":[{"database":"PubMed","id":"34922257"},{"database":"DOI","id":"10.1016/j.virol.2021.12.002"}],"title":"The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells.","publicationDate":"2022","journal":"Virology","firstPage":"136","lastPage":"142","volume":"566"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)"]},{"referenceNumber":75,"citation":{"id":"36585612","citationType":"journal article","authors":["Shin J.","Kim Y.H.","Lee B.","Chang J.H.","Choi H.Y.","Lee H.","Song K.C.","Kwak M.S.","Choi J.E.","Shin J.S."],"citationCrossReferences":[{"database":"PubMed","id":"36585612"},{"database":"DOI","id":"10.1186/s10020-022-00596-0"}],"title":"USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity.","publicationDate":"2022","journal":"Mol. Med.","firstPage":"164","lastPage":"164","volume":"28"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":76,"citation":{"id":"34971702","citationType":"journal article","authors":["Chaudhary N.","Srivastava S.","Dave U.","Ojha A.","Guchhait P.","Chandele A.","Patel A.K."],"citationCrossReferences":[{"database":"PubMed","id":"34971702"},{"database":"DOI","id":"10.1016/j.virusres.2021.198668"}],"title":"High-mobility group box 1 protein promotes dengue virus replication by interacting with untranslated regions of viral genome.","publicationDate":"2022","journal":"Virus Res.","firstPage":"198668","lastPage":"198668","volume":"309"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","SUBCELLULAR LOCATION"]},{"referenceNumber":77,"citation":{"id":"35239449","citationType":"journal article","authors":["Zhang X.","Yang Z.","Pan T.","Long X.","Sun Q.","Wang P.H.","Li X.","Kuang E."],"citationCrossReferences":[{"database":"PubMed","id":"35239449"},{"database":"DOI","id":"10.1080/15548627.2022.2039992"}],"title":"SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection.","publicationDate":"2022","journal":"Autophagy","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH SARS-COV-2 ORF3A","SUBCELLULAR LOCATION (MICROBIAL INFECTION)"]},{"referenceNumber":78,"citation":{"id":"CI-20FVUVHJGDPEV","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Solution structure of the tandem HMG box domain from human high mobility group protein B1.","publicationDate":"FEB-2008","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR OF 1-166"]},{"referenceNumber":79,"citation":{"id":"23063560","citationType":"journal article","authors":["Rowell J.P.","Simpson K.L.","Stott K.","Watson M.","Thomas J.O."],"citationCrossReferences":[{"database":"PubMed","id":"23063560"},{"database":"DOI","id":"10.1016/j.str.2012.09.004"}],"title":"HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail.","publicationDate":"2012","journal":"Structure","firstPage":"2014","lastPage":"2024","volume":"20"},"referencePositions":["STRUCTURE BY NMR OF 2-84 IN COMPLEX WITH TP53","FUNCTION","DOMAIN"]},{"referenceNumber":80,"citation":{"id":"24427810","citationType":"journal article","authors":["Wang J.","Tochio N.","Takeuchi A.","Uewaki J.","Kobayashi N.","Tate S."],"citationCrossReferences":[{"database":"PubMed","id":"24427810"},{"database":"DOI","id":"10.1016/j.bbrc.2013.10.085"}],"title":"Redox-sensitive structural change in the A-domain of HMGB1 and its implication for the binding to cisplatin modified DNA.","publicationDate":"2013","journal":"Biochem. Biophys. Res. Commun.","firstPage":"701","lastPage":"706","volume":"441"},"referencePositions":["STRUCTURE BY NMR OF 1-84"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X12597","properties":[{"key":"ProteinId","value":"CAA31110.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U51677","properties":[{"key":"ProteinId","value":"AAB08987.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"D63874","properties":[{"key":"ProteinId","value":"BAA09924.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF157968","properties":[{"key":"ProteinId","value":"ABM47301.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY377859","properties":[{"key":"ProteinId","value":"AAQ91389.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291494","properties":[{"key":"ProteinId","value":"BAF84183.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK122825","properties":[{"key":"ProteinId","value":"BAG53745.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR749614","properties":[{"key":"ProteinId","value":"CAH18408.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR456863","properties":[{"key":"ProteinId","value":"CAG33144.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT006940","properties":[{"key":"ProteinId","value":"AAP35586.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT020159","properties":[{"key":"ProteinId","value":"AAV38961.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EU012027","properties":[{"key":"ProteinId","value":"ABS29271.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL353648","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471075","properties":[{"key":"ProteinId","value":"EAX08457.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC003378","properties":[{"key":"ProteinId","value":"AAH03378.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC030981","properties":[{"key":"ProteinId","value":"AAH30981.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC066889","properties":[{"key":"ProteinId","value":"AAH66889.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC067732","properties":[{"key":"ProteinId","value":"AAH67732.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC141844","properties":[{"key":"ProteinId","value":"AAI41845.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS9335.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S02826","properties":[{"key":"EntryName","value":"S02826"}]},{"database":"RefSeq","id":"NP_001300821.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001313892.2"}]},{"database":"RefSeq","id":"NP_001300822.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001313893.1"}]},{"database":"RefSeq","id":"NP_001357269.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001370340.1"}]},{"database":"RefSeq","id":"NP_001357270.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001370341.1"}]},{"database":"RefSeq","id":"NP_001432849.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001445920.1"}]},{"database":"RefSeq","id":"NP_002119.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002128.7"}]},{"database":"PDB","id":"2LY4","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-84"}]},{"database":"PDB","id":"2RTU","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-84"}]},{"database":"PDB","id":"2YRQ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-166"}]},{"database":"PDB","id":"6CG0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.17 A"},{"key":"Chains","value":"N=15-140"}]},{"database":"PDB","id":"6CIJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"N=1-163"}]},{"database":"PDB","id":"6CIK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.15 A"},{"key":"Chains","value":"N=1-163"}]},{"database":"PDB","id":"6CIL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.15 A"},{"key":"Chains","value":"N=1-163"}]},{"database":"PDB","id":"6CIM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"N=1-163"}]},{"database":"PDB","id":"6OEM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"H/N=15-155"}]},{"database":"PDB","id":"6OEN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.30 A"},{"key":"Chains","value":"H/N=1-163"}]},{"database":"PDB","id":"6OEO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.69 A"},{"key":"Chains","value":"N=1-163"}]},{"database":"PDB","id":"8I9M","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.19 A"},{"key":"Chains","value":"A=89-163"}]},{"database":"PDB","id":"9CG9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.94 A"},{"key":"Chains","value":"K=1-215"}]},{"database":"PDBsum","id":"2LY4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2RTU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2YRQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CG0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CIJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CIK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CIL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CIM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6OEM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6OEN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6OEO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8I9M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CG9","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20030","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20031","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20032","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35276","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45578","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7470","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7480","properties":[{"key":"Description","value":"-"}]},{"database":"PCDDB","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109389","properties":[{"key":"Interactions","value":"593"}]},{"database":"CORUM","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-24195N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P09429","properties":[{"key":"Number of interactors","value":"1876"}]},{"database":"IntAct","id":"P09429","properties":[{"key":"Interactions","value":"286"}]},{"database":"MINT","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-HMGB1","properties":[{"key":"Evidences","value":"17 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000345347","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2311236","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB00608","properties":[{"key":"GenericName","value":"Chloroquine"}]},{"database":"DrugBank","id":"DB05869","properties":[{"key":"GenericName","value":"Ethyl pyruvate"}]},{"database":"DrugCentral","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"3279","properties":[{"key":"Description","value":"-"}]},{"database":"MoonProt","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P09429","properties":[{"key":"glycosylation","value":"2 sites, 1 glycan"}]},{"database":"GlyGen","id":"P09429","properties":[{"key":"glycosylation","value":"6 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)"}]},{"database":"iPTMnet","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HMGB1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"123369","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000345347","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52217","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P09429","properties":[{"key":"antibodies","value":"24 sequenced antibodies"}]},{"database":"Antibodypedia","id":"3132","properties":[{"key":"antibodies","value":"1726 antibodies from 49 providers"}]},{"database":"CPTC","id":"P09429","properties":[{"key":"antibodies","value":"1 antibody"}]},{"database":"DNASU","id":"3146","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000339872.8","properties":[{"key":"ProteinId","value":"ENSP00000343040.4"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000341423.10","properties":[{"key":"ProteinId","value":"ENSP00000345347.5"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000399494.5","properties":[{"key":"ProteinId","value":"ENSP00000382417.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000405805.5","properties":[{"key":"ProteinId","value":"ENSP00000384678.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897840.1","properties":[{"key":"ProteinId","value":"ENSP00000567899.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897841.1","properties":[{"key":"ProteinId","value":"ENSP00000567900.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897842.1","properties":[{"key":"ProteinId","value":"ENSP00000567901.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897843.1","properties":[{"key":"ProteinId","value":"ENSP00000567902.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897844.1","properties":[{"key":"ProteinId","value":"ENSP00000567903.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897845.1","properties":[{"key":"ProteinId","value":"ENSP00000567904.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897846.1","properties":[{"key":"ProteinId","value":"ENSP00000567905.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897847.1","properties":[{"key":"ProteinId","value":"ENSP00000567906.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897848.1","properties":[{"key":"ProteinId","value":"ENSP00000567907.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897849.1","properties":[{"key":"ProteinId","value":"ENSP00000567908.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897850.1","properties":[{"key":"ProteinId","value":"ENSP00000567909.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897851.1","properties":[{"key":"ProteinId","value":"ENSP00000567910.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897852.1","properties":[{"key":"ProteinId","value":"ENSP00000567911.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897853.1","properties":[{"key":"ProteinId","value":"ENSP00000567912.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897854.1","properties":[{"key":"ProteinId","value":"ENSP00000567913.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897855.1","properties":[{"key":"ProteinId","value":"ENSP00000567914.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000897856.1","properties":[{"key":"ProteinId","value":"ENSP00000567915.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000927781.1","properties":[{"key":"ProteinId","value":"ENSP00000597840.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000927782.1","properties":[{"key":"ProteinId","value":"ENSP00000597841.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000927785.1","properties":[{"key":"ProteinId","value":"ENSP00000597844.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000970317.1","properties":[{"key":"ProteinId","value":"ENSP00000640376.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"Ensembl","id":"ENST00000970318.1","properties":[{"key":"ProteinId","value":"ENSP00000640377.1"},{"key":"GeneId","value":"ENSG00000189403.16"}]},{"database":"GeneID","id":"3146","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3146","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000341423.10","properties":[{"key":"ProteinId","value":"ENSP00000345347.5"},{"key":"RefSeqNucleotideId","value":"NM_002128.7"},{"key":"RefSeqProteinId","value":"NP_002119.1"}]},{"database":"UCSC","id":"uc001usx.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:4983","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA188","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3146","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3146","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HMGB1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:4983","properties":[{"key":"GeneName","value":"HMGB1"}]},{"database":"HPA","id":"ENSG00000189403","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"HMGB1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"163905","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000189403","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000189403","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0381","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183120","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PHSANEV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9484645at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P09429","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1236974","properties":[{"key":"PathwayName","value":"ER-Phagosome pathway"}]},{"database":"Reactome","id":"R-HSA-140342","properties":[{"key":"PathwayName","value":"Apoptosis induced DNA fragmentation"}]},{"database":"Reactome","id":"R-HSA-166058","properties":[{"key":"PathwayName","value":"MyD88:MAL(TIRAP) cascade initiated on plasma membrane"}]},{"database":"Reactome","id":"R-HSA-3000471","properties":[{"key":"PathwayName","value":"Scavenging by Class B Receptors"}]},{"database":"Reactome","id":"R-HSA-445989","properties":[{"key":"PathwayName","value":"TAK1-dependent IKK and NF-kappa-B activation"}]},{"database":"Reactome","id":"R-HSA-5602498","properties":[{"key":"PathwayName","value":"MyD88 deficiency (TLR2/4)"}]},{"database":"Reactome","id":"R-HSA-5603041","properties":[{"key":"PathwayName","value":"IRAK4 deficiency (TLR2/4)"}]},{"database":"Reactome","id":"R-HSA-5620971","properties":[{"key":"PathwayName","value":"Pyroptosis"}]},{"database":"Reactome","id":"R-HSA-5686938","properties":[{"key":"PathwayName","value":"Regulation of TLR by endogenous ligand"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-HSA-879415","properties":[{"key":"PathwayName","value":"Advanced glycosylation endproduct receptor signaling"}]},{"database":"Reactome","id":"R-HSA-933542","properties":[{"key":"PathwayName","value":"TRAF6 mediated NF-kB activation"}]},{"database":"SignaLink","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000189403","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3146","properties":[{"key":"hits","value":"313 hits in 1115 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"HMGB1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P09429","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"HMGB1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3146","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P09429","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P09429","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"RNAct","id":"P09429","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000189403","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 181 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P09429","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0035868","properties":[{"key":"GoTerm","value":"C:alphav-beta3 integrin-HMGB1 complex"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20826760"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19841752"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000793","properties":[{"key":"GoTerm","value":"C:condensed chromosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12925773"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154118"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12231511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17114460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20819940"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22869893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29618516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33147444"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34971702"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35239449"}]},{"database":"GO","id":"GO:0005793","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum-Golgi intermediate compartment"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19841752"}]},{"database":"GO","id":"GO:1904813","properties":[{"key":"GoTerm","value":"C:ficolin-1-rich granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0043005","properties":[{"key":"GoTerm","value":"C:neuron projection"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19223331"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8339930"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154118"}]},{"database":"GO","id":"GO:0034774","properties":[{"key":"GoTerm","value":"C:secretory granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0017053","properties":[{"key":"GoTerm","value":"C:transcription repressor complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19158276"}]},{"database":"GO","id":"GO:0000405","properties":[{"key":"GoTerm","value":"F:bubble DNA binding"},{"key":"GoEvidenceType","value":"ISS:AgBase"}]},{"database":"GO","id":"GO:0019958","properties":[{"key":"GoTerm","value":"F:C-X-C chemokine binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22370717"}]},{"database":"GO","id":"GO:0010858","properties":[{"key":"GoTerm","value":"F:calcium-dependent protein kinase regulator activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042056","properties":[{"key":"GoTerm","value":"F:chemoattractant activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005125","properties":[{"key":"GoTerm","value":"F:cytokine activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0003684","properties":[{"key":"GoTerm","value":"F:damaged DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17803946"}]},{"database":"GO","id":"GO:0008301","properties":[{"key":"GoTerm","value":"F:DNA binding, bending"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19223331"}]},{"database":"GO","id":"GO:0070182","properties":[{"key":"GoTerm","value":"F:DNA polymerase binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17803946"}]},{"database":"GO","id":"GO:0140297","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19223331"}]},{"database":"GO","id":"GO:0003690","properties":[{"key":"GoTerm","value":"F:double-stranded DNA binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0003725","properties":[{"key":"GoTerm","value":"F:double-stranded RNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0140656","properties":[{"key":"GoTerm","value":"F:endodeoxyribonuclease activator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17803946"}]},{"database":"GO","id":"GO:0000400","properties":[{"key":"GoTerm","value":"F:four-way junction DNA binding"},{"key":"GoEvidenceType","value":"ISS:AgBase"}]},{"database":"GO","id":"GO:0005178","properties":[{"key":"GoTerm","value":"F:integrin binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20826760"}]},{"database":"GO","id":"GO:0001530","properties":[{"key":"GoTerm","value":"F:lipopolysaccharide binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21660935"}]},{"database":"GO","id":"GO:0016829","properties":[{"key":"GoTerm","value":"F:lyase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17803946"}]},{"database":"GO","id":"GO:0001786","properties":[{"key":"GoTerm","value":"F:phosphatidylserine binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18768881"}]},{"database":"GO","id":"GO:0030295","properties":[{"key":"GoTerm","value":"F:protein kinase activator activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050786","properties":[{"key":"GoTerm","value":"F:RAGE receptor binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17568691"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22681889"}]},{"database":"GO","id":"GO:0061629","properties":[{"key":"GoTerm","value":"F:RNA polymerase II-specific DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19223331"}]},{"database":"GO","id":"GO:0003697","properties":[{"key":"GoTerm","value":"F:single-stranded DNA binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0003727","properties":[{"key":"GoTerm","value":"F:single-stranded RNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097100","properties":[{"key":"GoTerm","value":"F:supercoiled DNA binding"},{"key":"GoEvidenceType","value":"ISS:AgBase"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19158276"}]},{"database":"GO","id":"GO:0003713","properties":[{"key":"GoTerm","value":"F:transcription coactivator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19223331"}]},{"database":"GO","id":"GO:0003714","properties":[{"key":"GoTerm","value":"F:transcription corepressor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11748232"}]},{"database":"GO","id":"GO:0002218","properties":[{"key":"GoTerm","value":"P:activation of innate immune response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24971542"}]},{"database":"GO","id":"GO:0043277","properties":[{"key":"GoTerm","value":"P:apoptotic cell clearance"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18768881"}]},{"database":"GO","id":"GO:0006284","properties":[{"key":"GoTerm","value":"P:base-excision repair"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071222","properties":[{"key":"GoTerm","value":"P:cellular response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0006338","properties":[{"key":"GoTerm","value":"P:chromatin remodeling"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0002407","properties":[{"key":"GoTerm","value":"P:dendritic cell chemotaxis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032392","properties":[{"key":"GoTerm","value":"P:DNA geometric change"},{"key":"GoEvidenceType","value":"ISS:AgBase"}]},{"database":"GO","id":"GO:0006310","properties":[{"key":"GoTerm","value":"P:DNA recombination"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006265","properties":[{"key":"GoTerm","value":"P:DNA topological change"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006302","properties":[{"key":"GoTerm","value":"P:double-strand break repair"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006303","properties":[{"key":"GoTerm","value":"P:double-strand break repair via nonhomologous end joining"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035767","properties":[{"key":"GoTerm","value":"P:endothelial cell chemotaxis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001935","properties":[{"key":"GoTerm","value":"P:endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031507","properties":[{"key":"GoTerm","value":"P:heterochromatin formation"},{"key":"GoEvidenceType","value":"IGI:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"19158276"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23146691"}]},{"database":"GO","id":"GO:0002437","properties":[{"key":"GoTerm","value":"P:inflammatory response to antigenic stimulus"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"19841752"}]},{"database":"GO","id":"GO:0002281","properties":[{"key":"GoTerm","value":"P:macrophage activation involved in immune response"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001773","properties":[{"key":"GoTerm","value":"P:myeloid dendritic cell activation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2000426","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic cell clearance"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20826760"}]},{"database":"GO","id":"GO:0043537","properties":[{"key":"GoTerm","value":"P:negative regulation of blood vessel endothelial cell migration"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23148224"}]},{"database":"GO","id":"GO:0043371","properties":[{"key":"GoTerm","value":"P:negative regulation of CD4-positive, alpha-beta T cell differentiation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22473704"}]},{"database":"GO","id":"GO:0017055","properties":[{"key":"GoTerm","value":"P:negative regulation of RNA polymerase II transcription preinitiation complex assembly"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8006019"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11748232"}]},{"database":"GO","id":"GO:0032689","properties":[{"key":"GoTerm","value":"P:negative regulation of type II interferon production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22473704"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0097350","properties":[{"key":"GoTerm","value":"P:neutrophil clearance"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18768881"}]},{"database":"GO","id":"GO:0002270","properties":[{"key":"GoTerm","value":"P:plasmacytoid dendritic cell activation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042104","properties":[{"key":"GoTerm","value":"P:positive regulation of activated T cell proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15944249"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19800306"}]},{"database":"GO","id":"GO:0010508","properties":[{"key":"GoTerm","value":"P:positive regulation of autophagy"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20819940"}]},{"database":"GO","id":"GO:0043536","properties":[{"key":"GoTerm","value":"P:positive regulation of blood vessel endothelial cell migration"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28276476"}]},{"database":"GO","id":"GO:2000343","properties":[{"key":"GoTerm","value":"P:positive regulation of chemokine (C-X-C motif) ligand 2 production"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26961863"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22370717"}]},{"database":"GO","id":"GO:2001200","properties":[{"key":"GoTerm","value":"P:positive regulation of dendritic cell differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15944249"}]},{"database":"GO","id":"GO:0043388","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11748232"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19223331"}]},{"database":"GO","id":"GO:0070374","properties":[{"key":"GoTerm","value":"P:positive regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22370717"}]},{"database":"GO","id":"GO:0032727","properties":[{"key":"GoTerm","value":"P:positive regulation of interferon-alpha production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032728","properties":[{"key":"GoTerm","value":"P:positive regulation of interferon-beta production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032731","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-1 beta production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032732","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-1 production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12765338"}]},{"database":"GO","id":"GO:0032733","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-10 production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22473704"}]},{"database":"GO","id":"GO:0032735","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-12 production"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15944249"}]},{"database":"GO","id":"GO:0032755","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-6 production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12765338"}]},{"database":"GO","id":"GO:0032757","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-8 production"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26961863"}]},{"database":"GO","id":"GO:0046330","properties":[{"key":"GoTerm","value":"P:positive regulation of JNK cascade"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12765338"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12765338"}]},{"database":"GO","id":"GO:0032425","properties":[{"key":"GoTerm","value":"P:positive regulation of mismatch repair"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15014079"}]},{"database":"GO","id":"GO:0071639","properties":[{"key":"GoTerm","value":"P:positive regulation of monocyte chemotactic protein-1 production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0090026","properties":[{"key":"GoTerm","value":"P:positive regulation of monocyte chemotaxis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22370717"}]},{"database":"GO","id":"GO:1901224","properties":[{"key":"GoTerm","value":"P:positive regulation of non-canonical NF-kappaB signal transduction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903672","properties":[{"key":"GoTerm","value":"P:positive regulation of sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034137","properties":[{"key":"GoTerm","value":"P:positive regulation of toll-like receptor 2 signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034145","properties":[{"key":"GoTerm","value":"P:positive regulation of toll-like receptor 4 signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034165","properties":[{"key":"GoTerm","value":"P:positive regulation of toll-like receptor 9 signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19223331"}]},{"database":"GO","id":"GO:0032760","properties":[{"key":"GoTerm","value":"P:positive regulation of tumor necrosis factor production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12765338"}]},{"database":"GO","id":"GO:1905564","properties":[{"key":"GoTerm","value":"P:positive regulation of vascular endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28276476"}]},{"database":"GO","id":"GO:0046598","properties":[{"key":"GoTerm","value":"P:positive regulation of viral entry into host cell"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"33147444"}]},{"database":"GO","id":"GO:0090303","properties":[{"key":"GoTerm","value":"P:positive regulation of wound healing"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:2000819","properties":[{"key":"GoTerm","value":"P:regulation of nucleotide-excision repair"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002840","properties":[{"key":"GoTerm","value":"P:regulation of T cell mediated immune response to tumor cell"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0002643","properties":[{"key":"GoTerm","value":"P:regulation of tolerance induction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18631454"}]},{"database":"GO","id":"GO:0035711","properties":[{"key":"GoTerm","value":"P:T-helper 1 cell activation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22473704"}]},{"database":"GO","id":"GO:0045063","properties":[{"key":"GoTerm","value":"P:T-helper 1 cell differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15944249"}]},{"database":"GO","id":"GO:0033151","properties":[{"key":"GoTerm","value":"P:V(D)J recombination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9166431"}]},{"database":"CDD","id":"cd21978","properties":[{"key":"EntryName","value":"HMG-box_HMGB_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21979","properties":[{"key":"EntryName","value":"HMG-box_HMGB_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP01493","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"1.10.30.10:FF:000006","properties":[{"key":"EntryName","value":"High mobility group protein B1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.30.10:FF:000015","properties":[{"key":"EntryName","value":"high mobility group protein B1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.30.10","properties":[{"key":"EntryName","value":"High mobility group box domain"},{"key":"MatchStatus","value":"2"}]},{"database":"IDEAL","id":"IID00297","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR009071","properties":[{"key":"EntryName","value":"HMG_box_dom"}]},{"database":"InterPro","id":"IPR036910","properties":[{"key":"EntryName","value":"HMG_box_dom_sf"}]},{"database":"InterPro","id":"IPR017967","properties":[{"key":"EntryName","value":"HMG_boxA_CS"}]},{"database":"InterPro","id":"IPR050342","properties":[{"key":"EntryName","value":"HMGB"}]},{"database":"PANTHER","id":"PTHR48112:SF35","properties":[{"key":"EntryName","value":"HIGH MOBILITY GROUP PROTEIN B1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48112","properties":[{"key":"EntryName","value":"HIGH MOBILITY GROUP PROTEIN DSP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00505","properties":[{"key":"EntryName","value":"HMG_box"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09011","properties":[{"key":"EntryName","value":"HMG_box_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00886","properties":[{"key":"EntryName","value":"HIGHMOBLTY12"}]},{"database":"SMART","id":"SM00398","properties":[{"key":"EntryName","value":"HMG"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF47095","properties":[{"key":"EntryName","value":"HMG-box"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00353","properties":[{"key":"EntryName","value":"HMG_BOX_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50118","properties":[{"key":"EntryName","value":"HMG_BOX_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE","length":215,"molWeight":24894,"crc64":"8A868CF277D417B5","md5":"3A98F2059F7E9361E2776130200C2DCE"},"extraAttributes":{"countByCommentType":{"FUNCTION":8,"SUBUNIT":4,"INTERACTION":15,"SUBCELLULAR LOCATION":2,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":2,"PTM":6,"MISCELLANEOUS":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Chain":1,"DNA binding":2,"Region":7,"Motif":2,"Compositional bias":3,"Binding site":1,"Site":2,"Modified residue":26,"Disulfide bond":1,"Cross-link":8,"Natural variant":4,"Mutagenesis":14,"Sequence conflict":2,"Beta strand":5,"Helix":9},"uniParcId":"UPI00000015ED"}}