{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P08046","secondaryAccessions":["Q61777"],"uniProtkbId":"EGR1_MOUSE","entryAudit":{"firstPublicDate":"1988-08-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-11-01","entryVersion":224,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Early growth response protein 1"},"shortNames":[{"value":"EGR-1"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1740423"}],"value":"Nerve growth factor-induced protein A"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1740423"}],"value":"NGFI-A"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2028256"}],"value":"Transcription factor Zif268"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2511075"}],"value":"Zinc finger protein Krox-24"}}]},"genes":[{"geneName":{"value":"Egr1"},"synonyms":[{"value":"Egr-1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2511075"}],"value":"Krox-24"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P18146"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11100120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15265859"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15958557"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26471974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29138967"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8336701"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8703054"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0000305"}],"value":"Transcriptional regulator (PubMed:15958557, PubMed:8336701, PubMed:8703054). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:15958557, PubMed:2028256, PubMed:8703054, PubMed:8939742). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia (PubMed:11100120, PubMed:15958557). Plays a role in the regulation of cell survival, proliferation and cell death (PubMed:15265859, PubMed:15958557). Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation (PubMed:15958557). Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy (PubMed:15265859). Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia (PubMed:11100120). Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (PubMed:8703054). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription (PubMed:26471974). Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (PubMed:29138967)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P18146"}],"value":"Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11100120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15958557"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8336701"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P18146"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11100120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15265859"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26471974"}],"value":"Detected in lung vasculature and in mononuclear phagocytes (PubMed:11100120). Detected in liver (at protein level) (PubMed:15265859). Expressed in the liver in a circadian manner (PubMed:26471974)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11100120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15265859"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3133658"}],"value":"By growth factors (PubMed:3133658). Up-regulated in lung vasculature in response to reperfusion after ischemia (PubMed:11100120). Up-regulated in liver in response to partial hepatectomy (PubMed:15265859)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P18146"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1740423"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"}],"value":"Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers (PubMed:1740423, PubMed:2028256, PubMed:8336701, PubMed:8939742). The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif (PubMed:2028256, PubMed:8939742). Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (By similarity)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11100120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15265859"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15958557"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29138967"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8703054"}],"value":"Mice appear grossly normal, but females are anestrous and infertile with an uterus weight that is roughly 30% of that of wild-type. Ovaries contain normal numbers of follicles, but lack corpora lutea. Serum progesterone levels are strongly reduced; estradiol levels are normal. The level of luteinizing hormone (LHB) in the pituitary is strongly reduced in males and not detectable in females (PubMed:8703054). Responses to ischemia and hypoxia are blunted, leading to reduced tissue damage in response to ischemia and increased survival (PubMed:11100120). Liver regeneration is impaired after partial hepatectomy, due to impaired mitotic progress and reduced proliferation of hepatocytes (PubMed:15265859). Untreated mutant mice do not display an increased tendency to develop tumors, but develop tumors earlier than wild-type when treated first with a tumor initiator, and then with a tumor promoter (PubMed:15958557). Mice lack daily rhythmicity in the expression of the core-clock gene BMAL1 and display a reduced and altered locomotor activity and altered temperature regulation (PubMed:29138967)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the EGR C2H2-type zinc-finger protein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"Early growth response protein 1","featureId":"PRO_0000047110"},{"type":"Zinc finger","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"C2H2-type 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00042"}]},{"type":"Zinc finger","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"C2H2-type 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00042"}]},{"type":"Zinc finger","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"C2H2-type 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00042"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"type":"Site","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"type":"Site","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"type":"Site","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"type":"Site","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"type":"Site","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"type":"Site","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"type":"Site","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"type":"Site","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2028256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8939742"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"type":"Cross-link","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P18146"}]},{"type":"Sequence conflict","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"in Ref. 3; AAB00468 and 4; AAA39382","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"in Ref. 3; AAB00468 and 4; AAA39382","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Helix","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1F2I"}]},{"type":"Beta strand","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1P47"}]},{"type":"Beta strand","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1A1H"}]},{"type":"Beta strand","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1A1H"}]},{"type":"Helix","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1A1H"}]},{"type":"Turn","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LLM"}]},{"type":"Beta strand","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LLM"}]},{"type":"Helix","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LLM"}]},{"type":"Turn","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LLM"}]},{"type":"Beta strand","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LLM"}]},{"type":"Helix","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LLM"}]},{"type":"Helix","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1A1H"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"3127059","citationType":"journal article","authors":["Sukhatme V.P.","Cao X.","Chang L.C.","Tsai-Morris C.-H.","Stamenkovich D.","Ferreira P.C.P.","Cohen D.R.","Edwards S.A.","Shows T.B.","Curran T.","le Beau M.M.","Adamson E.D."],"citationCrossReferences":[{"database":"PubMed","id":"3127059"},{"database":"DOI","id":"10.1016/0092-8674(88)90485-0"}],"title":"A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.","publicationDate":"1988","journal":"Cell","firstPage":"37","lastPage":"43","volume":"53"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"3141919","citationType":"journal article","authors":["Christy B.A.","Lau L.F.","Nathans D."],"citationCrossReferences":[{"database":"PubMed","id":"3141919"},{"database":"DOI","id":"10.1073/pnas.85.21.7857"}],"title":"A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with 'zinc finger' sequences.","publicationDate":"1988","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7857","lastPage":"7861","volume":"85"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"2511075","citationType":"journal article","authors":["Janssen-Timmen U.","Lemaire P.","Mattei M.-G.","Revelant O.","Charnay P."],"citationCrossReferences":[{"database":"PubMed","id":"2511075"},{"database":"DOI","id":"10.1016/0378-1119(89)90296-5"}],"title":"Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24; evidence for a common regulatory pathway for immediate-early serum-response genes.","publicationDate":"1989","journal":"Gene","firstPage":"325","lastPage":"336","volume":"80"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"3133658","citationType":"journal article","authors":["Lemaire P.","Revelant O.","Bravo R.","Charnay P."],"citationCrossReferences":[{"database":"PubMed","id":"3133658"},{"database":"DOI","id":"10.1073/pnas.85.13.4691"}],"title":"Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.","publicationDate":"1988","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4691","lastPage":"4695","volume":"85"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 50-533","INDUCTION BY GROWTH FACTORS"]},{"referenceNumber":5,"citation":{"id":"1740423","citationType":"journal article","authors":["Wilson T.E.","Day M.L.","Pexton T.","Padgett K.A.","Johnston M.","Milbrandt J."],"citationCrossReferences":[{"database":"PubMed","id":"1740423"},{"database":"DOI","id":"10.1016/s0021-9258(19)50584-1"}],"title":"In vivo mutational analysis of the NGFI-A zinc fingers.","publicationDate":"1992","journal":"J. Biol. Chem.","firstPage":"3718","lastPage":"3724","volume":"267"},"referencePositions":["MUTAGENESIS OF ZINC-FINGERS","DOMAIN"]},{"referenceNumber":6,"citation":{"id":"8336701","citationType":"journal article","authors":["Gashler A.L.","Swaminathan S.","Sukhatme V.P."],"citationCrossReferences":[{"database":"PubMed","id":"8336701"},{"database":"DOI","id":"10.1128/mcb.13.8.4556-4571.1993"}],"title":"A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1.","publicationDate":"1993","journal":"Mol. Cell. Biol.","firstPage":"4556","lastPage":"4571","volume":"13"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","DOMAIN"]},{"referenceNumber":7,"citation":{"id":"8703054","citationType":"journal article","authors":["Lee S.L.","Sadovsky Y.","Swirnoff A.H.","Polish J.A.","Goda P.","Gavrilina G.","Milbrandt J."],"citationCrossReferences":[{"database":"PubMed","id":"8703054"},{"database":"DOI","id":"10.1126/science.273.5279.1219"}],"title":"Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).","publicationDate":"1996","journal":"Science","firstPage":"1219","lastPage":"1221","volume":"273"},"referencePositions":["DISRUPTION PHENOTYPE","FUNCTION"]},{"referenceNumber":8,"citation":{"id":"11100120","citationType":"journal article","authors":["Yan S.F.","Fujita T.","Lu J.","Okada K.","Shan Zou Y.","Mackman N.","Pinsky D.J.","Stern D.M."],"citationCrossReferences":[{"database":"PubMed","id":"11100120"},{"database":"DOI","id":"10.1038/82168"}],"title":"Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress.","publicationDate":"2000","journal":"Nat. Med.","firstPage":"1355","lastPage":"1361","volume":"6"},"referencePositions":["DISRUPTION PHENOTYPE","FUNCTION","TISSUE SPECIFICITY","SUBCELLULAR LOCATION","INDUCTION BY ISCHEMIA"]},{"referenceNumber":9,"citation":{"id":"15265859","citationType":"journal article","authors":["Liao Y.","Shikapwashya O.N.","Shteyer E.","Dieckgraefe B.K.","Hruz P.W.","Rudnick D.A."],"citationCrossReferences":[{"database":"PubMed","id":"15265859"},{"database":"DOI","id":"10.1074/jbc.m407969200"}],"title":"Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"43107","lastPage":"43116","volume":"279"},"referencePositions":["DISRUPTION PHENOTYPE","FUNCTION","TISSUE SPECIFICITY","INDUCTION BY PARTIAL HEPATECTOMY"]},{"referenceNumber":10,"citation":{"id":"15958557","citationType":"journal article","authors":["Krones-Herzig A.","Mittal S.","Yule K.","Liang H.","English C.","Urcis R.","Soni T.","Adamson E.D.","Mercola D."],"citationCrossReferences":[{"database":"PubMed","id":"15958557"},{"database":"DOI","id":"10.1158/0008-5472.can-04-3742"}],"title":"Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53.","publicationDate":"2005","journal":"Cancer Res.","firstPage":"5133","lastPage":"5143","volume":"65"},"referencePositions":["DISRUPTION PHENOTYPE","FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"26471974","citationType":"journal article","authors":["Tao W.","Wu J.","Zhang Q.","Lai S.S.","Jiang S.","Jiang C.","Xu Y.","Xue B.","Du J.","Li C.J."],"citationCrossReferences":[{"database":"PubMed","id":"26471974"},{"database":"DOI","id":"10.1038/srep15212"}],"title":"EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription.","publicationDate":"2015","journal":"Sci. Rep.","firstPage":"15212","lastPage":"15212","volume":"5"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":12,"citation":{"id":"29138967","citationType":"journal article","authors":["Riedel C.S.","Georg B.","Joergensen H.L.","Hannibal J.","Fahrenkrug J."],"citationCrossReferences":[{"database":"PubMed","id":"29138967"},{"database":"DOI","id":"10.1007/s12031-017-0996-8"}],"title":"Mice lacking EGR1 have impaired clock gene (BMAL1) oscillation, locomotor activity, and body temperature.","publicationDate":"2018","journal":"J. Mol. Neurosci.","firstPage":"9","lastPage":"19","volume":"64"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":13,"citation":{"id":"2028256","citationType":"journal article","authors":["Pavletich N.P.","Pabo C.O."],"citationCrossReferences":[{"database":"PubMed","id":"2028256"},{"database":"DOI","id":"10.1126/science.2028256"}],"title":"Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A.","publicationDate":"1991","journal":"Science","firstPage":"809","lastPage":"817","volume":"252"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 332-418 IN COMPLEX WITH ZINC AND TARGET DNA","DOMAIN","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1ZAA"}]},{"referenceNumber":14,"citation":{"id":"8939742","citationType":"journal article","authors":["Elrod-Erickson M.","Rould M.A.","Nekludova L.","Pabo C.O."],"citationCrossReferences":[{"database":"PubMed","id":"8939742"},{"database":"DOI","id":"10.1016/s0969-2126(96)00125-6"}],"title":"Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions.","publicationDate":"1996","journal":"Structure","firstPage":"1171","lastPage":"1180","volume":"4"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 333-421 IN COMPLEX WITH ZINC AND TARGET DNA","DOMAIN","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1AAY"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M20157","properties":[{"key":"ProteinId","value":"AAA37544.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M22326","properties":[{"key":"ProteinId","value":"AAA40416.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M28845","properties":[{"key":"ProteinId","value":"AAB00468.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M28844","properties":[{"key":"ProteinId","value":"AAB00468.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M19643","properties":[{"key":"ProteinId","value":"AAA39382.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS29136.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"JS0304","properties":[{"key":"EntryName","value":"JS0304"}]},{"database":"RefSeq","id":"NP_031939.1","properties":[{"key":"NucleotideSequenceId","value":"NM_007913.5"}]},{"database":"PDB","id":"1A1F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1A1G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1A1H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1A1I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1A1J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1A1K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1A1L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1AAY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1F2I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"G/H/I/J/K/L=319-389"}]},{"database":"PDB","id":"1G2D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"C/F=333-421"}]},{"database":"PDB","id":"1G2F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"C/F=333-421"}]},{"database":"PDB","id":"1JK1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1JK2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=333-421"}]},{"database":"PDB","id":"1LLM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"C/D=363-412"}]},{"database":"PDB","id":"1P47","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B=333-419"}]},{"database":"PDB","id":"1ZAA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"C=332-418"}]},{"database":"PDBsum","id":"1A1F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1A1G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1A1H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1A1I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1A1J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1A1K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1A1L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1AAY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1F2I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1G2D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1G2F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JK1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JK2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1LLM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1P47","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1ZAA","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P08046","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P08046","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P08046","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"199404","properties":[{"key":"Interactions","value":"9"}]},{"database":"FunCoup","id":"P08046","properties":[{"key":"Number of interactors","value":"2128"}]},{"database":"IntAct","id":"P08046","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"10090.ENSMUSP00000069616","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P08046","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"P08046","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P08046","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000069616","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"275907","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P08046","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"14988","properties":[{"key":"antibodies","value":"560 antibodies from 44 providers"}]},{"database":"DNASU","id":"13653","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000064795.6","properties":[{"key":"ProteinId","value":"ENSMUSP00000069616.6"},{"key":"GeneId","value":"ENSMUSG00000038418.9"}]},{"database":"GeneID","id":"13653","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:13653","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008elt.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:95295","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1958","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:95295","properties":[{"key":"GeneName","value":"Egr1"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000038418","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1721","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000160184","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_043235_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P08046","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NFQVPMI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10018191at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P08046","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"13653","properties":[{"key":"hits","value":"4 hits in 83 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"P08046","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P08046","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 18"}]},{"database":"RNAct","id":"P08046","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000038418","properties":[{"key":"ExpressionPatterns","value":"Expressed in associated mesenchyme of midgut and 293 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P08046","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11100120"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12689920"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18323529"}]},{"database":"GO","id":"GO:0001228","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20018936"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12689920"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0003690","properties":[{"key":"GoTerm","value":"F:double-stranded DNA binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0010385","properties":[{"key":"GoTerm","value":"F:double-stranded methylated DNA binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0019899","properties":[{"key":"GoTerm","value":"F:enzyme binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"31467272"}]},{"database":"GO","id":"GO:0044729","properties":[{"key":"GoTerm","value":"F:hemi-methylated DNA-binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035035","properties":[{"key":"GoTerm","value":"F:histone acetyltransferase binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:1990841","properties":[{"key":"GoTerm","value":"F:promoter-specific chromatin binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20018936"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31467272"}]},{"database":"GO","id":"GO:0000979","properties":[{"key":"GoTerm","value":"F:RNA polymerase II core promoter sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15958557"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18281035"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030509","properties":[{"key":"GoTerm","value":"P:BMP signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8769660"}]},{"database":"GO","id":"GO:0071480","properties":[{"key":"GoTerm","value":"P:cellular response to gamma radiation"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19057511"}]},{"database":"GO","id":"GO:0071504","properties":[{"key":"GoTerm","value":"P:cellular response to heparin"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098759","properties":[{"key":"GoTerm","value":"P:cellular response to interleukin-8"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071506","properties":[{"key":"GoTerm","value":"P:cellular response to mycophenolic acid"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032922","properties":[{"key":"GoTerm","value":"P:circadian regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26471974"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29138967"}]},{"database":"GO","id":"GO:0060086","properties":[{"key":"GoTerm","value":"P:circadian temperature homeostasis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29138967"}]},{"database":"GO","id":"GO:0044849","properties":[{"key":"GoTerm","value":"P:estrous cycle"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8703054"}]},{"database":"GO","id":"GO:0072110","properties":[{"key":"GoTerm","value":"P:glomerular mesangial cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070498","properties":[{"key":"GoTerm","value":"P:interleukin-1-mediated signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045475","properties":[{"key":"GoTerm","value":"P:locomotor rhythm"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29138967"}]},{"database":"GO","id":"GO:0007616","properties":[{"key":"GoTerm","value":"P:long-term memory"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0090090","properties":[{"key":"GoTerm","value":"P:negative regulation of canonical Wnt signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18281035"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16033766"}]},{"database":"GO","id":"GO:0032722","properties":[{"key":"GoTerm","value":"P:positive regulation of chemokine production"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11100120"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12689920"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7720589"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0044029","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression via chromosomal CpG island demethylation"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"31467272"}]},{"database":"GO","id":"GO:0072303","properties":[{"key":"GoTerm","value":"P:positive regulation of glomerular metanephric mesangial cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046886","properties":[{"key":"GoTerm","value":"P:positive regulation of hormone biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8703054"}]},{"database":"GO","id":"GO:0032731","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-1 beta production"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11100120"}]},{"database":"GO","id":"GO:1902895","properties":[{"key":"GoTerm","value":"P:positive regulation of miRNA transcription"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043525","properties":[{"key":"GoTerm","value":"P:positive regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:1901875","properties":[{"key":"GoTerm","value":"P:positive regulation of post-translational protein modification"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0014911","properties":[{"key":"GoTerm","value":"P:positive regulation of smooth muscle cell migration"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048661","properties":[{"key":"GoTerm","value":"P:positive regulation of smooth muscle cell proliferation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20018936"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31467272"}]},{"database":"GO","id":"GO:0042981","properties":[{"key":"GoTerm","value":"P:regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23277542"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12165491"}]},{"database":"GO","id":"GO:0048169","properties":[{"key":"GoTerm","value":"P:regulation of long-term neuronal synaptic plasticity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043523","properties":[{"key":"GoTerm","value":"P:regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:2000182","properties":[{"key":"GoTerm","value":"P:regulation of progesterone biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8703054"}]},{"database":"GO","id":"GO:0033233","properties":[{"key":"GoTerm","value":"P:regulation of protein sumoylation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18323529"}]},{"database":"GO","id":"GO:0009749","properties":[{"key":"GoTerm","value":"P:response to glucose"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12689920"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11100120"}]},{"database":"GO","id":"GO:0032868","properties":[{"key":"GoTerm","value":"P:response to insulin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12689920"}]},{"database":"GO","id":"GO:0002931","properties":[{"key":"GoTerm","value":"P:response to ischemia"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11100120"}]},{"database":"GO","id":"GO:0035914","properties":[{"key":"GoTerm","value":"P:skeletal muscle cell differentiation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22147266"}]},{"database":"GO","id":"GO:0030217","properties":[{"key":"GoTerm","value":"P:T cell differentiation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12165491"}]},{"database":"FunFam","id":"3.30.160.60:FF:000769","properties":[{"key":"EntryName","value":"Early growth response 2b"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.60:FF:000324","properties":[{"key":"EntryName","value":"Early growth response protein 4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.60:FF:000419","properties":[{"key":"EntryName","value":"Early growth response protein 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR021839","properties":[{"key":"EntryName","value":"EGR1_C"}]},{"database":"InterPro","id":"IPR021849","properties":[{"key":"EntryName","value":"EGR_N"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR013087","properties":[{"key":"EntryName","value":"Znf_C2H2_type"}]},{"database":"PANTHER","id":"PTHR23235:SF42","properties":[{"key":"EntryName","value":"EARLY GROWTH RESPONSE PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23235","properties":[{"key":"EntryName","value":"KRUEPPEL-LIKE TRANSCRIPTION FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11914","properties":[{"key":"EntryName","value":"DUF3432"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11928","properties":[{"key":"EntryName","value":"DUF3446"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00096","properties":[{"key":"EntryName","value":"zf-C2H2"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00355","properties":[{"key":"EntryName","value":"ZnF_C2H2"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00028","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50157","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_2"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGGNSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKAMVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSSSASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPATKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQDLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASPAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGFPSPSVATTFASVPPAFPTQVSSFPSAGVSSSFSTSTGLSDMTATFSPRTIEIC","length":533,"molWeight":56590,"crc64":"36E3935767CEAA0F","md5":"1EAD2C34A60E934887FC67B275B0BE52"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Zinc finger":3,"Region":4,"Compositional bias":4,"Site":9,"Cross-link":1,"Sequence conflict":2,"Helix":5,"Beta strand":5,"Turn":2},"uniParcId":"UPI000000402D"}}