{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P07900","secondaryAccessions":["A8K500","B3KPJ9","Q2PP14","Q5CAQ6","Q5CAQ7","Q9BVQ5"],"uniProtkbId":"HS90A_HUMAN","entryAudit":{"firstPublicDate":"1988-08-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-01-23","entryVersion":286,"sequenceVersion":5},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Heat shock protein HSP 90-alpha"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12526792"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"value":"Heat shock 86 kDa"},"shortNames":[{"value":"HSP 86"},{"value":"HSP86"}]},{"fullName":{"value":"Heat shock protein family C member 1"}},{"fullName":{"value":"Lipopolysaccharide-associated protein 2"},"shortNames":[{"value":"LAP-2"},{"value":"LPS-associated protein 2"}]},{"fullName":{"value":"Renal carcinoma antigen NY-REN-38"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:5253"}],"value":"HSP90AA1"},"synonyms":[{"value":"HSP90A"},{"value":"HSPC1"},{"value":"HSPCA"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11274138"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11276205"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12526792"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15577939"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15937123"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628368"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24613385"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25609812"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27353360"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25973397"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26991466"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"27295069"}],"value":"Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22066472"}],"value":"(Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12526792"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18400751"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"}],"value":"In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation (PubMed:18400751). Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation (PubMed:18400751). After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state (PubMed:18400751). Co-chaperone TSC1 promotes ATP binding and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Binding to phosphorylated AHSA1 promotes HSP90AA1 ATPase activity (PubMed:29127155). Inhibited by geldanamycin, Ganetespib (STA-9090) and SNX-2112 (PubMed:12526792, PubMed:29127155)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":300.0,"unit":"uM","substrate":"ATP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18400751"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P82995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10409742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11274138"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11276205"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11583998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12526792"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12604615"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12853476"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15235609"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15383005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15577939"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15708368"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16307917"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16531226"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17028174"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17947705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18400751"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19875381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20353823"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628368"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23569206"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24613385"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24681825"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25738358"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26517842"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26754925"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27353360"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30559449"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41742417"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7588731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8289821"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9195923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660753"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9817749"}],"value":"Homodimer (PubMed:18400751, PubMed:29127155, PubMed:7588731, PubMed:8289821). Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1 (PubMed:15383005, PubMed:9195923). Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex (PubMed:29127155). The closed form interacts (via the middle domain and TPR repeat-binding motif) with co-chaperone TSC1 (via C-terminus) (PubMed:29127155). Interacts with TOM34 (PubMed:9660753). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (PubMed:11274138, PubMed:9817749). Interacts with CHORDC1 and DNAJC7 (PubMed:12853476, PubMed:19875381). Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems (PubMed:16307917, PubMed:27353360). Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226, PubMed:27353360). Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 (PubMed:11276205). Interacts with KSR1 (PubMed:10409742). Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity (PubMed:23569206, PubMed:27353360). May interact with NWD1 (PubMed:24681825). Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity (PubMed:17028174, PubMed:27353360). Interacts with co-chaperone AHSA1 (phosphorylated on 'Tyr-223'); the interaction activates HSP90AA1 ATPase activity and results in the dissociation of TSC1 from HSP90AA1 (PubMed:12604615, PubMed:27353360, PubMed:29127155). Interacts with FLCN in the presence of FNIP1 (PubMed:27353360). Interacts with HSP70, STIP1 and PTGES3 (PubMed:27353360). Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase (PubMed:15235609, PubMed:25738358). Interacts with SGTA (via TPR repeats) (PubMed:15708368). Interacts with TTC1 (via TPR repeats) (PubMed:15708368). Interacts with HSF1 in an ATP-dependent manner (PubMed:11583998, PubMed:26517842). Interacts with MET; the interaction suppresses MET kinase activity (PubMed:26517842). Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (PubMed:26517842). Interacts with HIF1A, KEAP1 and RHOBTB2 (PubMed:26517842). Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities (PubMed:26754925). Interacts with STUB1 and SMAD3 (PubMed:24613385). Interacts with HSP90AB1; interaction is constitutive (PubMed:20353823). Interacts with HECTD1 (via N-terminus) (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with NLPR12 (PubMed:17947705, PubMed:30559449). Interacts with PDCL3 (By similarity). Interacts with TOMM70; the interaction is required for preprotein mitochondrial import (PubMed:12526792). Interacts with TOMM70, IRF3 and TBK1; the interactions are direct and mediate the association of TOMM70 with IRF3 and TBK1 (PubMed:20628368). Forms a complex with ASL, ASS1 and NOS2; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway. Interacts with RNASEK; the interaction is increased by arsenite and heat stress (PubMed:41742417)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29743370"}],"value":"(Microbial infection) Interacts with herpes simplex virus 1 protein US11; this interaction inhibits TBK1-induced interferon production"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22066472"}],"value":"(Microbial infection) Interacts with N.meningitidis serogroup B adhesin A (nadA). Interaction is stabilized by ADP and 17-AAG (17-N-allylamino-17-demethoxygeldanamycin) and inhibited by ATP. Decreasing HSP90 levels increases adhesion and entry of bacterial into human Chang cells; increasing its levels leads to decreased adhseion and invasion"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q6UY14-3","geneName":"ADAMTSL4","intActId":"EBI-10173507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"O95433","geneName":"AHSA1","intActId":"EBI-448610"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9Y243","geneName":"AKT3","intActId":"EBI-296115"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q16671","geneName":"AMHR2","intActId":"EBI-6423788"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9H0C5","geneName":"BTBD1","intActId":"EBI-935503"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9UQM7","geneName":"CAMK2A","intActId":"EBI-1383687"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q8IWD4","geneName":"CCDC117","intActId":"EBI-3387963"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9BV29","geneName":"CCDC32","intActId":"EBI-2874058"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q16543","geneName":"CDC37","intActId":"EBI-295634"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q7L3B6","geneName":"CDC37L1","intActId":"EBI-2841876"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q96Q40","geneName":"CDK15","intActId":"EBI-1051975"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P50750","geneName":"CDK9","intActId":"EBI-1383449"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q96G23","geneName":"CERS2","intActId":"EBI-1057080"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9UHD1","geneName":"CHORDC1","intActId":"EBI-2550959"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"O15111","geneName":"CHUK","intActId":"EBI-81249"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q6QEF8-4","geneName":"CORO6","intActId":"EBI-10699285"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q14194","geneName":"CRMP1","intActId":"EBI-473101"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P35222","geneName":"CTNNB1","intActId":"EBI-491549"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q15438","geneName":"CYTH1","intActId":"EBI-997830"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9NR20","geneName":"DYRK4","intActId":"EBI-3914009"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P04626","geneName":"ERBB2","intActId":"EBI-641062"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q02790","geneName":"FKBP4","intActId":"EBI-1047444"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q13451","geneName":"FKBP5","intActId":"EBI-306914"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q14318","geneName":"FKBP8","intActId":"EBI-724839"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P06241","geneName":"FYN","intActId":"EBI-515315"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q96LI6-3","geneName":"HSFY2","intActId":"EBI-25830912"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P07900","geneName":"HSP90AA1","intActId":"EBI-296047"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q6PK50","geneName":"HSP90AB1","intActId":"EBI-9356629"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9Y6K9","geneName":"IKBKG","intActId":"EBI-81279"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9UHH9","geneName":"IP6K2","intActId":"EBI-747509"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P05412","geneName":"JUN","intActId":"EBI-852823"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q92993-2","geneName":"KAT5","intActId":"EBI-20795332"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q6VAB6","geneName":"KSR2","intActId":"EBI-6424389"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P06239","geneName":"LCK","intActId":"EBI-1348"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q99558","geneName":"MAP3K14","intActId":"EBI-358011"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"O43318-2","geneName":"MAP3K7","intActId":"EBI-358700"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P00540","geneName":"MOS","intActId":"EBI-1757866"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P04150","geneName":"NR3C1","intActId":"EBI-493507"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q8WVJ2","geneName":"NUDCD2","intActId":"EBI-1052153"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P43034","geneName":"PAFAH1B1","intActId":"EBI-720620"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P53041","geneName":"PPP5C","intActId":"EBI-716663"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P17612","geneName":"PRKACA","intActId":"EBI-476586"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q8WUY3","geneName":"PRUNE2","intActId":"EBI-743880"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q96QS6","geneName":"PSKH2","intActId":"EBI-6424813"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q15185","geneName":"PTGES3","intActId":"EBI-1049387"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P04049","geneName":"RAF1","intActId":"EBI-365996"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q13127","geneName":"REST","intActId":"EBI-926706"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9H6T3","geneName":"RPAP3","intActId":"EBI-356928"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P61247","geneName":"RPS3A","intActId":"EBI-352378"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P12931","geneName":"SRC","intActId":"EBI-621482"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q15831","geneName":"STK11","intActId":"EBI-306838"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9UNE7","geneName":"STUB1","intActId":"EBI-357085"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"O94826","geneName":"TOMM70","intActId":"EBI-2800236"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9BXA6","geneName":"TSSK6","intActId":"EBI-851883"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P10599","geneName":"TXN","intActId":"EBI-594644"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q8IWX7","geneName":"UNC45B","intActId":"EBI-9363363"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"Q9H6R7-2","geneName":"WDCP","intActId":"EBI-25833271"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P26882","geneName":"PPID","intActId":"EBI-6477155"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P07900","intActId":"EBI-296047"},"interactantTwo":{"uniProtKBAccession":"P35467","geneName":"S100a1","intActId":"EBI-6477109"},"numberOfExperiments":4,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Identified by mass spectrometry in melanosome fractions from stage I to stage IV"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17081065"}],"value":"Melanosome","id":"SL-0161"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11276205"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25609812"}],"value":"Mitochondrion","id":"SL-0173"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41742417"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"HSP90AA1-1"},{"value":"HSP90-alpha 2"}],"isoformIds":["P07900-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"HSP90AA1-2"}],"isoformIds":["P07900-2"],"sequenceIds":["VSP_026604"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16307917"}],"value":"The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16139798"}],"value":"ISGylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15937123"}],"value":"S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}],"value":"Ubiquitinated via 'Lys-63'-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the heat shock protein 90 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2492519"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Heat shock protein HSP 90-alpha","featureId":"PRO_0000062911"},{"type":"Region","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Interaction with NR3C1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}]},{"type":"Region","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"Interaction with NR3C1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Interaction with FLCN and FNIP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27353360"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"Interaction with FNIP2 and TSC1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27353360"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"}]},{"type":"Region","location":{"start":{"value":628,"modifier":"EXACT"},"end":{"value":731,"modifier":"EXACT"}},"description":"Interaction with NR1D1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}]},{"type":"Region","location":{"start":{"value":682,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Required for homodimerization","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8289821"}]},{"type":"Region","location":{"start":{"value":700,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":728,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Essential for interaction with SMYD3, TSC1 and STIP1/HOP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25738358"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"}]},{"type":"Region","location":{"start":{"value":729,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Essential for interaction with SGTA and TTC1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15708368"}]},{"type":"Motif","location":{"start":{"value":723,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"TPR repeat-binding","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16307917"}]},{"type":"Compositional bias","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"Phosphothreonine; by PRKDC","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2507541"}]},{"type":"Modified residue","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"Phosphothreonine; by PRKDC","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2507541"}]},{"type":"Modified residue","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}]},{"type":"Modified residue","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}]},{"type":"Modified residue","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2492519"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18088087"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2492519"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16807684"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18088087"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19367720"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}]},{"type":"Modified residue","location":{"start":{"value":443,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P82995"}]},{"type":"Modified residue","location":{"start":{"value":458,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07901"}]},{"type":"Modified residue","location":{"start":{"value":585,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":598,"modifier":"EXACT"}},"description":"S-nitrosocysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15937123"}]},{"type":"Modified residue","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16269234"}],"featureId":"VSP_026604","alternativeSequence":{"originalSequence":"M","alternativeSequences":["MPPCSGGDGSTPPGPSLRDRDCPAQSAEYPRDRLDPRPGSPSEASSPPFLRSRAPVNWYQEKAQVFLWHLMVSGSTTLLCLWKQPFHVSAFPVTASLAFRQSQGAGQHLYKDLQPFILLRLLM"]}},{"type":"Mutagenesis","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Strong ATP-binding. Strong interaction with HSF1, HIF1A, ERBB2, MET, KEAP1 and RHOBTB2. No effect on interaction with TSC1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26517842"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Impaired ATP-binding. Strong interaction with HIF1A, MET, KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. Los of interaction with TSC1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26517842"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Abolishes ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18256191"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Loss of interaction with TSC1 and increases interaction with AHSA1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"No deffect on the interaction with TSC1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":598,"modifier":"EXACT"}},"description":"Reduces ATPase activity and client protein activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15937123"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19696785"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A","N","D"]}},{"type":"Mutagenesis","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":598,"modifier":"EXACT"}},"description":"Loss of S-nitrosylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15937123"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19696785"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":728,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Loss of interaction with TOMM70. No effect on interaction with IRF3.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25609812"}],"alternativeSequence":{"originalSequence":"MEEVD","alternativeSequences":["AAAA"]}},{"type":"Mutagenesis","location":{"start":{"value":728,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Loss of interaction with TSC1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29127155"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":729,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Loss of interaction with TOMM70.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628368"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":731,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Loss of interaction with TOMM70. No effect on interaction with IRF3.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628368"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25609812"}],"alternativeSequence":{"originalSequence":"VD","alternativeSequences":["AA"]}},{"type":"Sequence conflict","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"in Ref. 1; CAA33259","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"in Ref. 4; CAI64495 and 6; BAG51711","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"in Ref. 4; CAI64495 and 6; BAG51711","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in Ref. 15; AA sequence","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["D"]}},{"type":"Helix","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GQS"}]},{"type":"Helix","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GQS"}]},{"type":"Beta strand","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Helix","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Turn","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GPF"}]},{"type":"Helix","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Helix","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Beta strand","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Turn","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Beta strand","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Helix","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Helix","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Helix","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Helix","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Helix","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Beta strand","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Beta strand","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2WI6"}]},{"type":"Beta strand","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Beta strand","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9KMR"}]},{"type":"Beta strand","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Beta strand","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Turn","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JR6"}]},{"type":"Helix","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Helix","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Beta strand","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VHC"}]},{"type":"Beta strand","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TN5"}]},{"type":"Helix","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GQS"}]},{"type":"Helix","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2XJX"}]},{"type":"Beta strand","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KRJ"}]},{"type":"Helix","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KSQ"}]},{"type":"Helix","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Turn","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KSQ"}]},{"type":"Beta strand","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Turn","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KSQ"}]},{"type":"Helix","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":465,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Turn","location":{"start":{"value":468,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":490,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":499,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":506,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":521,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Turn","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":543,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":546,"modifier":"EXACT"},"end":{"value":548,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":555,"modifier":"EXACT"},"end":{"value":579,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3Q6M"}]},{"type":"Beta strand","location":{"start":{"value":584,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":603,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KRJ"}]},{"type":"Helix","location":{"start":{"value":608,"modifier":"EXACT"},"end":{"value":613,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":619,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RXZ"}]},{"type":"Helix","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KRJ"}]},{"type":"Turn","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":629,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KRJ"}]},{"type":"Beta strand","location":{"start":{"value":632,"modifier":"EXACT"},"end":{"value":636,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":652,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Helix","location":{"start":{"value":681,"modifier":"EXACT"},"end":{"value":696,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RY0"}]},{"type":"Beta strand","location":{"start":{"value":728,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4CGW"}]},{"type":"Natural variant","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"},"sequence":"P07900-2"},"description":"in dbSNP:rs8005905","featureCrossReferences":[{"database":"dbSNP","id":"rs8005905"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VAR_082835","alternativeSequence":{"originalSequence":"M","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0702","category":"PTM","name":"S-nitrosylation"},{"id":"KW-0346","category":"Biological process","name":"Stress response"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"2780322","citationType":"journal article","authors":["Soeda E.","Yokoyama K.","Yamazaki M.","Akaogi K.","Miwa T.","Imai T."],"citationCrossReferences":[{"database":"PubMed","id":"2780322"},{"database":"DOI","id":"10.1093/nar/17.17.7108"}],"title":"Nucleotide sequence of a full-length cDNA for 90 kDa heat-shock protein from human peripheral blood lymphocytes.","publicationDate":"1989","journal":"Nucleic Acids Res.","firstPage":"7108","lastPage":"7108","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Peripheral blood lymphocyte","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"1368637","citationType":"journal article","authors":["Yamazaki M.","Tashiro H.","Yokoyama K.","Soeda E."],"citationCrossReferences":[{"database":"PubMed","id":"1368637"},{"database":"DOI","id":"10.1271/bbb1961.54.3163"}],"title":"Molecular cloning of cDNA encoding a human heat-shock protein whose expression is induced by adenovirus type 12 E1A in HeLa cells.","publicationDate":"1990","journal":"Agric. Biol. Chem.","firstPage":"3163","lastPage":"3170","volume":"54"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"2527334","citationType":"journal article","authors":["Hickey E.","Brandon S.E.","Smale G.","Lloyd D.","Weber L.A."],"citationCrossReferences":[{"database":"PubMed","id":"2527334"},{"database":"DOI","id":"10.1128/mcb.9.6.2615-2626.1989"}],"title":"Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein.","publicationDate":"1989","journal":"Mol. Cell. Biol.","firstPage":"2615","lastPage":"2626","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"16269234","citationType":"journal article","authors":["Chen B.","Piel W.H.","Gui L.","Bruford E.","Monteiro A."],"citationCrossReferences":[{"database":"PubMed","id":"16269234"},{"database":"DOI","id":"10.1016/j.ygeno.2005.08.012"}],"title":"The HSP90 family of genes in the human genome: insights into their divergence and evolution.","publicationDate":"2005","journal":"Genomics","firstPage":"627","lastPage":"637","volume":"86"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)","NOMENCLATURE"]},{"referenceNumber":5,"citation":{"id":"CI-APNV2K4FQRL2N","citationType":"submission","authoringGroup":["NHLBI resequencing and genotyping service (RS&G)"],"publicationDate":"DEC-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"},{"value":"Teratocarcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.-L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","De Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruels T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.W.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"2469626","citationType":"journal article","authors":["Hoffmann T.","Hovemann B."],"citationCrossReferences":[{"database":"PubMed","id":"2469626"},{"database":"DOI","id":"10.1016/0378-1119(88)90182-5"}],"title":"Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens.","publicationDate":"1988","journal":"Gene","firstPage":"491","lastPage":"501","volume":"74"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-312"]},{"referenceNumber":10,"citation":{"id":"2591742","citationType":"journal article","authors":["Walter T.","Drabent B.","Krebs H.","Tomalak M.","Heiss S.","Benecke B.J.J."],"citationCrossReferences":[{"database":"PubMed","id":"2591742"},{"database":"DOI","id":"10.1016/0378-1119(89)90408-3"}],"title":"Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene.","publicationDate":"1989","journal":"Gene","firstPage":"105","lastPage":"115","volume":"83"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-312"]},{"referenceNumber":11,"citation":{"id":"CI-5JLPE8IQ42OFK","citationType":"submission","authors":["Lubec G.","Vishwanath V.","Chen W.-Q.","Sun Y."],"publicationDate":"DEC-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 101-112; 210-224; 300-314; 328-338; 346-355; 387-400; 465-478 AND 633-647","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Cajal-Retzius cell","type":"TISSUE"},{"value":"Fetal brain cortex","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-732"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"CI-BEF31CADHBFR9","citationType":"submission","authors":["Tanaka M.","Tanaka T.","Mitsui Y.","Yamamoto M.","Wood J.N."],"title":"The analysis of the genes reactive to monoclonal antibody, CE5.","publicationDate":"SEP-1996","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 539-732"],"referenceComments":[{"value":"Heart","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"2492519","citationType":"journal article","authors":["Lees-Miller S.P.","Anderson C.W."],"citationCrossReferences":[{"database":"PubMed","id":"2492519"},{"database":"DOI","id":"10.1016/s0021-9258(19)81631-9"}],"title":"Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"2431","lastPage":"2437","volume":"264"},"referencePositions":["PROTEIN SEQUENCE OF 2-21","PHOSPHORYLATION AT SER-231 AND SER-263"]},{"referenceNumber":15,"citation":{"id":"10409742","citationType":"journal article","authors":["Stewart S.","Sundaram M.","Zhang Y.","Lee J.","Han M.","Guan K.L."],"citationCrossReferences":[{"database":"PubMed","id":"10409742"},{"database":"DOI","id":"10.1128/mcb.19.8.5523"}],"title":"Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.","publicationDate":"1999","journal":"Mol. Cell. Biol.","firstPage":"5523","lastPage":"5534","volume":"19"},"referencePositions":["PROTEIN SEQUENCE OF 154-163 AND 186-191","INTERACTION WITH KSR1"]},{"referenceNumber":16,"citation":{"id":"15937123","citationType":"journal article","authors":["Martinez-Ruiz A.","Villanueva L.","Gonzalez de Orduna C.","Lopez-Ferrer D.","Higueras M.A.","Tarin C.","Rodriguez-Crespo I.","Vazquez J.","Lamas S."],"citationCrossReferences":[{"database":"PubMed","id":"15937123"},{"database":"DOI","id":"10.1073/pnas.0407294102"}],"title":"S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities.","publicationDate":"2005","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"8525","lastPage":"8530","volume":"102"},"referencePositions":["PROTEIN SEQUENCE OF 592-612","FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF CYS-598","S-NITROSYLATION AT CYS-598"]},{"referenceNumber":17,"citation":{"id":"2507541","citationType":"journal article","authors":["Lees-Miller S.P.","Anderson C.W."],"citationCrossReferences":[{"database":"PubMed","id":"2507541"},{"database":"DOI","id":"10.1016/s0021-9258(18)71488-9"}],"title":"The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"17275","lastPage":"17280","volume":"264"},"referencePositions":["PHOSPHORYLATION AT THR-5 AND THR-7"]},{"referenceNumber":18,"citation":{"id":"8289821","citationType":"journal article","authors":["Minami Y.","Kimura Y.","Kawasaki H.","Suzuki K.","Yahara I."],"citationCrossReferences":[{"database":"PubMed","id":"8289821"},{"database":"DOI","id":"10.1128/mcb.14.2.1459-1464.1994"}],"title":"The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo.","publicationDate":"1994","journal":"Mol. Cell. Biol.","firstPage":"1459","lastPage":"1464","volume":"14"},"referencePositions":["HOMODIMERIZATION"]},{"referenceNumber":19,"citation":{"id":"7588731","citationType":"journal article","authors":["Nemoto T.","Ohara-Nemoto Y.","Ota M.","Takagi T.","Yokoyama K."],"citationCrossReferences":[{"database":"PubMed","id":"7588731"},{"database":"DOI","id":"10.1111/j.1432-1033.1995.001_1.x"}],"title":"Mechanism of dimer formation of the 90-kDa heat-shock protein.","publicationDate":"1995","journal":"Eur. J. Biochem.","firstPage":"1","lastPage":"8","volume":"233"},"referencePositions":["SUBUNIT"]},{"referenceNumber":20,"citation":{"id":"9195923","citationType":"journal article","authors":["Silverstein A.M.","Galigniana M.D.","Chen M.S.","Owens-Grillo J.K.","Chinkers M.","Pratt W.B."],"citationCrossReferences":[{"database":"PubMed","id":"9195923"},{"database":"DOI","id":"10.1074/jbc.272.26.16224"}],"title":"Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"16224","lastPage":"16230","volume":"272"},"referencePositions":["IDENTIFICATION IN A COMPLEX WITH NR3C1 AND FKBP4; PPID; PPP5C OR STIP1"]},{"referenceNumber":21,"citation":{"id":"9660753","citationType":"journal article","authors":["Young J.C.","Obermann W.M.","Hartl F.U."],"citationCrossReferences":[{"database":"PubMed","id":"9660753"},{"database":"DOI","id":"10.1074/jbc.273.29.18007"}],"title":"Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"18007","lastPage":"18010","volume":"273"},"referencePositions":["INTERACTION WITH TOM34"]},{"referenceNumber":22,"citation":{"id":"10508479","citationType":"journal article","authors":["Scanlan M.J.","Gordan J.D.","Williamson B.","Stockert E.","Bander N.H.","Jongeneel C.V.","Gure A.O.","Jaeger D.","Jaeger E.","Knuth A.","Chen Y.-T.","Old L.J."],"citationCrossReferences":[{"database":"PubMed","id":"10508479"},{"database":"DOI","id":"10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5"}],"title":"Antigens recognized by autologous antibody in patients with renal-cell carcinoma.","publicationDate":"1999","journal":"Int. J. Cancer","firstPage":"456","lastPage":"464","volume":"83"},"referencePositions":["IDENTIFICATION AS A RENAL CANCER ANTIGEN"],"referenceComments":[{"value":"Renal cell carcinoma","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"11274138","citationType":"journal article","authors":["Forsythe H.L.","Jarvis J.L.","Turner J.W.","Elmore L.W.","Holt S.E."],"citationCrossReferences":[{"database":"PubMed","id":"11274138"},{"database":"DOI","id":"10.1074/jbc.c100055200"}],"title":"Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"15571","lastPage":"15574","volume":"276"},"referencePositions":["INTERACTION WITH TERT","FUNCTION AS A CO-CHAPERONE IN TELOMERASE HOLOENZYME ASSEMBLY"]},{"referenceNumber":24,"citation":{"id":"11583998","citationType":"journal article","authors":["Guo Y.","Guettouche T.","Fenna M.","Boellmann F.","Pratt W.B.","Toft D.O.","Smith D.F.","Voellmy R."],"citationCrossReferences":[{"database":"PubMed","id":"11583998"},{"database":"DOI","id":"10.1074/jbc.m105931200"}],"title":"Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"45791","lastPage":"45799","volume":"276"},"referencePositions":["INTERACTION WITH HSF1"]},{"referenceNumber":25,"citation":{"id":"11276205","citationType":"journal article","authors":["Triantafilou K.","Triantafilou M.","Dedrick R.L."],"citationCrossReferences":[{"database":"PubMed","id":"11276205"},{"database":"DOI","id":"10.1038/86342"}],"title":"A CD14-independent LPS receptor cluster.","publicationDate":"2001","journal":"Nat. Immunol.","firstPage":"338","lastPage":"345","volume":"2"},"referencePositions":["FUNCTION","IDENTIFICATION AS LPS RECEPTOR","INTERACTION WITH CXCR4; GDF5 AND HSPA8","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":26,"citation":{"id":"12526792","citationType":"journal article","authors":["Young J.C.","Hoogenraad N.J.","Hartl F.U."],"citationCrossReferences":[{"database":"PubMed","id":"12526792"},{"database":"DOI","id":"10.1016/s0092-8674(02)01250-3"}],"title":"Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70.","publicationDate":"2003","journal":"Cell","firstPage":"41","lastPage":"50","volume":"112"},"referencePositions":["FUNCTION","INTERACTION WITH TOMM70","CATALYTIC ACTIVITY"]},{"referenceNumber":27,"citation":{"id":"12853476","citationType":"journal article","authors":["Brychzy A.","Rein T.","Winklhofer K.F.","Hartl F.U.","Young J.C.","Obermann W.M."],"citationCrossReferences":[{"database":"PubMed","id":"12853476"},{"database":"DOI","id":"10.1093/emboj/cdg362"}],"title":"Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.","publicationDate":"2003","journal":"EMBO J.","firstPage":"3613","lastPage":"3623","volume":"22"},"referencePositions":["INTERACTION WITH DNAJC7"]},{"referenceNumber":28,"citation":{"id":"12604615","citationType":"journal article","authors":["Lotz G.P.","Lin H.","Harst A.","Obermann W.M.J."],"citationCrossReferences":[{"database":"PubMed","id":"12604615"},{"database":"DOI","id":"10.1074/jbc.m212761200"}],"title":"Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"17228","lastPage":"17235","volume":"278"},"referencePositions":["INTERACTION WITH AHSA1"]},{"referenceNumber":29,"citation":{"id":"14654843","citationType":"journal article","authors":["Andersen J.S.","Wilkinson C.J.","Mayor T.","Mortensen P.","Nigg E.A.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"14654843"},{"database":"DOI","id":"10.1038/nature02166"}],"title":"Proteomic characterization of the human centrosome by protein correlation profiling.","publicationDate":"2003","journal":"Nature","firstPage":"570","lastPage":"574","volume":"426"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Lymphoblast","type":"TISSUE"}]},{"referenceNumber":30,"citation":{"id":"15235609","citationType":"journal article","authors":["Hamamoto R.","Furukawa Y.","Morita M.","Iimura Y.","Silva F.P.","Li M.","Yagyu R.","Nakamura Y."],"citationCrossReferences":[{"database":"PubMed","id":"15235609"},{"database":"DOI","id":"10.1038/ncb1151"}],"title":"SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.","publicationDate":"2004","journal":"Nat. Cell Biol.","firstPage":"731","lastPage":"740","volume":"6"},"referencePositions":["INTERACTION WITH SMYD3"]},{"referenceNumber":31,"citation":{"id":"15708368","citationType":"journal article","authors":["Liou S.T.","Wang C."],"citationCrossReferences":[{"database":"PubMed","id":"15708368"},{"database":"DOI","id":"10.1016/j.abb.2004.12.020"}],"title":"Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.","publicationDate":"2005","journal":"Arch. Biochem. Biophys.","firstPage":"253","lastPage":"263","volume":"435"},"referencePositions":["INTERACTION WITH SGTA AND TTC1"]},{"referenceNumber":32,"citation":{"id":"15383005","citationType":"journal article","authors":["Zeke T.","Morrice N.","Vazquez-Martin C.","Cohen P.T."],"citationCrossReferences":[{"database":"PubMed","id":"15383005"},{"database":"DOI","id":"10.1042/bj20040690"}],"title":"Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.","publicationDate":"2005","journal":"Biochem. J.","firstPage":"45","lastPage":"56","volume":"385"},"referencePositions":["INTERACTION WITH PPP5C","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":33,"citation":{"id":"15577939","citationType":"journal article","authors":["Yang J.","Roe S.M.","Cliff M.J.","Williams M.A.","Ladbury J.E.","Cohen P.T.","Barford D."],"citationCrossReferences":[{"database":"PubMed","id":"15577939"},{"database":"DOI","id":"10.1038/sj.emboj.7600496"}],"title":"Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.","publicationDate":"2005","journal":"EMBO J.","firstPage":"1","lastPage":"10","volume":"24"},"referencePositions":["FUNCTION","INTERACTION WITH PPP5C"]},{"referenceNumber":34,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-263","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":35,"citation":{"id":"16807684","citationType":"journal article","authors":["Beranova-Giorgianni S.","Zhao Y.","Desiderio D.M.","Giorgianni F."],"citationCrossReferences":[{"database":"PubMed","id":"16807684"},{"database":"DOI","id":"10.1007/s11102-006-8916-x"}],"title":"Phosphoproteomic analysis of the human pituitary.","publicationDate":"2006","journal":"Pituitary","firstPage":"109","lastPage":"120","volume":"9"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":36,"citation":{"id":"16531226","citationType":"journal article","authors":["Cliff M.J.","Harris R.","Barford D.","Ladbury J.E.","Williams M.A."],"citationCrossReferences":[{"database":"PubMed","id":"16531226"},{"database":"DOI","id":"10.1016/j.str.2005.12.009"}],"title":"Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.","publicationDate":"2006","journal":"Structure","firstPage":"415","lastPage":"426","volume":"14"},"referencePositions":["INTERACTION WITH PPP5C"]},{"referenceNumber":37,"citation":{"id":"17947705","citationType":"journal article","authors":["Arthur J.C.","Lich J.D.","Aziz R.K.","Kotb M.","Ting J.P."],"citationCrossReferences":[{"database":"PubMed","id":"17947705"},{"database":"DOI","id":"10.4049/jimmunol.179.9.6291"}],"title":"Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.","publicationDate":"2007","journal":"J. Immunol.","firstPage":"6291","lastPage":"6296","volume":"179"},"referencePositions":["INTERACTION WITH NLRP12"]},{"referenceNumber":38,"citation":{"id":"18400751","citationType":"journal article","authors":["Richter K.","Soroka J.","Skalniak L.","Leskovar A.","Hessling M.","Reinstein J.","Buchner J."],"citationCrossReferences":[{"database":"PubMed","id":"18400751"},{"database":"DOI","id":"10.1074/jbc.m800540200"}],"title":"Conserved conformational changes in the ATPase cycle of human Hsp90.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"17757","lastPage":"17765","volume":"283"},"referencePositions":["SUBUNIT","ACTIVITY REGULATION","BIOPHYSICOCHEMICAL PROPERTIES"]},{"referenceNumber":39,"citation":{"id":"19367720","citationType":"journal article","authors":["Carrascal M.","Ovelleiro D.","Casas V.","Gay M.","Abian J."],"citationCrossReferences":[{"database":"PubMed","id":"19367720"},{"database":"DOI","id":"10.1021/pr800500r"}],"title":"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"5167","lastPage":"5176","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"T-cell","type":"TISSUE"}]},{"referenceNumber":40,"citation":{"id":"18088087","citationType":"journal article","authors":["Zahedi R.P.","Lewandrowski U.","Wiesner J.","Wortelkamp S.","Moebius J.","Schuetz C.","Walter U.","Gambaryan S.","Sickmann A."],"citationCrossReferences":[{"database":"PubMed","id":"18088087"},{"database":"DOI","id":"10.1021/pr0704130"}],"title":"Phosphoproteome of resting human platelets.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"526","lastPage":"534","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252 AND SER-263","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":41,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":42,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":43,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-263","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":44,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":45,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":46,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-443; LYS-458; LYS-489 AND LYS-585","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":47,"citation":{"id":"19875381","citationType":"journal article","authors":["Gano J.J.","Simon J.A."],"citationCrossReferences":[{"database":"PubMed","id":"19875381"},{"database":"DOI","id":"10.1074/mcp.m900261-mcp200"}],"title":"A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.","publicationDate":"2010","journal":"Mol. Cell. Proteomics","firstPage":"255","lastPage":"270","volume":"9"},"referencePositions":["INTERACTION WITH CHORDC1"]},{"referenceNumber":48,"citation":{"id":"16139798","citationType":"journal article","authors":["Giannakopoulos N.V.","Luo J.K.","Papov V.","Zou W.","Lenschow D.J.","Jacobs B.S.","Borden E.C.","Li J.","Virgin H.W.","Zhang D.E."],"citationCrossReferences":[{"database":"PubMed","id":"16139798"},{"database":"DOI","id":"10.1016/j.bbrc.2005.08.132"}],"title":"Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.","publicationDate":"2005","journal":"Biochem. Biophys. Res. Commun.","firstPage":"496","lastPage":"506","volume":"336"},"referencePositions":["ISGYLATION"]},{"referenceNumber":49,"citation":{"id":"17081065","citationType":"journal article","authors":["Chi A.","Valencia J.C.","Hu Z.-Z.","Watabe H.","Yamaguchi H.","Mangini N.J.","Huang H.","Canfield V.A.","Cheng K.C.","Yang F.","Abe R.","Yamagishi S.","Shabanowitz J.","Hearing V.J.","Wu C.","Appella E.","Hunt D.F."],"citationCrossReferences":[{"database":"PubMed","id":"17081065"},{"database":"DOI","id":"10.1021/pr060363j"}],"title":"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.","publicationDate":"2006","journal":"J. Proteome Res.","firstPage":"3135","lastPage":"3144","volume":"5"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Melanoma","type":"TISSUE"}]},{"referenceNumber":50,"citation":{"id":"17028174","citationType":"journal article","authors":["Baba M.","Hong S.-B.","Sharma N.","Warren M.B.","Nickerson M.L.","Iwamatsu A.","Esposito D.","Gillette W.K.","Hopkins R.F. III","Hartley J.L.","Furihata M.","Oishi S.","Zhen W.","Burke T.R. Jr.","Linehan W.M.","Schmidt L.S.","Zbar B."],"citationCrossReferences":[{"database":"PubMed","id":"17028174"},{"database":"DOI","id":"10.1073/pnas.0603781103"}],"title":"Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15552","lastPage":"15557","volume":"103"},"referencePositions":["INTERACTION WITH FNIP1","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":51,"citation":{"id":"18256191","citationType":"journal article","authors":["Hawkins T.A.","Haramis A.P.","Etard C.","Prodromou C.","Vaughan C.K.","Ashworth R.","Ray S.","Behra M.","Holder N.","Talbot W.S.","Pearl L.H.","Strahle U.","Wilson S.W."],"citationCrossReferences":[{"database":"PubMed","id":"18256191"},{"database":"DOI","id":"10.1242/dev.018150"}],"title":"The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis.","publicationDate":"2008","journal":"Development","firstPage":"1147","lastPage":"1156","volume":"135"},"referencePositions":["MUTAGENESIS OF GLY-97"]},{"referenceNumber":52,"citation":{"id":"19696785","citationType":"journal article","authors":["Retzlaff M.","Stahl M.","Eberl H.C.","Lagleder S.","Beck J.","Kessler H.","Buchner J."],"citationCrossReferences":[{"database":"PubMed","id":"19696785"},{"database":"DOI","id":"10.1038/embor.2009.153"}],"title":"Hsp90 is regulated by a switch point in the C-terminal domain.","publicationDate":"2009","journal":"EMBO Rep.","firstPage":"1147","lastPage":"1153","volume":"10"},"referencePositions":["MUTAGENESIS OF CYS-598"]},{"referenceNumber":53,"citation":{"id":"20628368","citationType":"journal article","authors":["Liu X.Y.","Wei B.","Shi H.X.","Shan Y.F.","Wang C."],"citationCrossReferences":[{"database":"PubMed","id":"20628368"},{"database":"DOI","id":"10.1038/cr.2010.103"}],"title":"Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.","publicationDate":"2010","journal":"Cell Res.","firstPage":"994","lastPage":"1011","volume":"20"},"referencePositions":["FUNCTION","INTERACTION WITH TOMM70; IRF3 AND TBK1","MUTAGENESIS OF 729-GLU--ASP-732"]},{"referenceNumber":54,"citation":{"id":"20353823","citationType":"journal article","authors":["Cheng M.B.","Zhang Y.","Zhong X.","Sutter B.","Cao C.Y.","Chen X.S.","Cheng X.K.","Zhang Y.","Xiao L.","Shen Y.F."],"citationCrossReferences":[{"database":"PubMed","id":"20353823"},{"database":"DOI","id":"10.1016/j.cellsig.2010.03.012"}],"title":"Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.","publicationDate":"2010","journal":"Cell. Signal.","firstPage":"1206","lastPage":"1213","volume":"22"},"referencePositions":["INTERACTION WITH HSP90AB1"]},{"referenceNumber":55,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":56,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":57,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":58,"citation":{"id":"22066472","citationType":"journal article","authors":["Montanari P.","Bozza G.","Capecchi B.","Caproni E.","Barrile R.","Norais N.","Capitani M.","Sallese M.","Cecchini P.","Ciucchi L.","Gao Z.","Rappuoli R.","Pizza M.","Arico B.","Merola M."],"citationCrossReferences":[{"database":"PubMed","id":"22066472"},{"database":"DOI","id":"10.1111/j.1462-5822.2011.01722.x"}],"title":"Human heat shock protein (Hsp) 90 interferes with Neisseria meningitidis adhesin A (NadA)-mediated adhesion and invasion.","publicationDate":"2012","journal":"Cell. Microbiol.","firstPage":"368","lastPage":"385","volume":"14"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH N.MENINGITIDIS ADHESIN A (MICROBIAL INFECTION)"]},{"referenceNumber":59,"citation":{"id":"23569206","citationType":"journal article","authors":["Eckl J.M.","Rutz D.A.","Haslbeck V.","Zierer B.K.","Reinstein J.","Richter K."],"citationCrossReferences":[{"database":"PubMed","id":"23569206"},{"database":"DOI","id":"10.1074/jbc.m112.439257"}],"title":"Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites.","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"16032","lastPage":"16042","volume":"288"},"referencePositions":["INTERACTION WITH CDC37"]},{"referenceNumber":60,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-252; SER-263; SER-476 AND SER-641","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":61,"citation":{"id":"24613385","citationType":"journal article","authors":["Shang Y.","Xu X.","Duan X.","Guo J.","Wang Y.","Ren F.","He D.","Chang Z."],"citationCrossReferences":[{"database":"PubMed","id":"24613385"},{"database":"DOI","id":"10.1016/j.bbrc.2014.02.124"}],"title":"Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.","publicationDate":"2014","journal":"Biochem. Biophys. Res. Commun.","firstPage":"387","lastPage":"392","volume":"446"},"referencePositions":["FUNCTION","INTERACTION WITH STUB1 AND SMAD3"]},{"referenceNumber":62,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":63,"citation":{"id":"24681825","citationType":"journal article","authors":["Correa R.G.","Krajewska M.","Ware C.F.","Gerlic M.","Reed J.C."],"citationCrossReferences":[{"database":"PubMed","id":"24681825"},{"database":"DOI","id":"10.18632/oncotarget.1850"}],"title":"The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.","publicationDate":"2014","journal":"Oncotarget","firstPage":"1666","lastPage":"1682","volume":"5"},"referencePositions":["INTERACTION WITH NWD1"]},{"referenceNumber":64,"citation":{"id":"25973397","citationType":"journal article","authors":["Khurana N.","Bhattacharyya S."],"citationCrossReferences":[{"database":"PubMed","id":"25973397"},{"database":"DOI","id":"10.3389/fonc.2015.00100"}],"title":"Hsp90, the concertmaster: tuning transcription.","publicationDate":"2015","journal":"Front. Oncol.","firstPage":"100","lastPage":"100","volume":"5"},"referencePositions":["REVIEW"]},{"referenceNumber":65,"citation":{"id":"25609812","citationType":"journal article","authors":["Wei B.","Cui Y.","Huang Y.","Liu H.","Li L.","Li M.","Ruan K.C.","Zhou Q.","Wang C."],"citationCrossReferences":[{"database":"PubMed","id":"25609812"},{"database":"DOI","id":"10.1128/jvi.02959-14"}],"title":"Tom70 mediates Sendai virus-induced apoptosis on mitochondria.","publicationDate":"2015","journal":"J. Virol.","firstPage":"3804","lastPage":"3818","volume":"89"},"referencePositions":["FUNCTION","INTERACTION WITH TOMM70 AND IRF3","SUBCELLULAR LOCATION","MUTAGENESIS OF 728-MET--ASP-732"]},{"referenceNumber":66,"citation":{"id":"25738358","citationType":"journal article","authors":["Brown M.A.","Foreman K.","Harriss J.","Das C.","Zhu L.","Edwards M.","Shaaban S.","Tucker H."],"citationCrossReferences":[{"database":"PubMed","id":"25738358"},{"database":"DOI","id":"10.18632/oncotarget.2970"}],"title":"C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis.","publicationDate":"2015","journal":"Oncotarget","firstPage":"4005","lastPage":"4019","volume":"6"},"referencePositions":["INTERACTION WITH SMYD3"]},{"referenceNumber":67,"citation":{"id":"26517842","citationType":"journal article","authors":["Prince T.L.","Kijima T.","Tatokoro M.","Lee S.","Tsutsumi S.","Yim K.","Rivas C.","Alarcon S.","Schwartz H.","Khamit-Kush K.","Scroggins B.T.","Beebe K.","Trepel J.B.","Neckers L."],"citationCrossReferences":[{"database":"PubMed","id":"26517842"},{"database":"DOI","id":"10.1371/journal.pone.0141786"}],"title":"Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.","publicationDate":"2015","journal":"PLoS ONE","firstPage":"E0141786","lastPage":"E0141786","volume":"10"},"referencePositions":["INTERACTION WITH HSF1; HIF1A; ERBB2; MET; KEAP1 AND RHOBTB2","MUTAGENESIS OF GLU-47 AND ASP-93"]},{"referenceNumber":68,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":69,"citation":{"id":"27295069","citationType":"journal article","authors":["Verma S.","Goyal S.","Jamal S.","Singh A.","Grover A."],"citationCrossReferences":[{"database":"PubMed","id":"27295069"},{"database":"DOI","id":"10.1016/j.biochi.2016.05.018"}],"title":"Hsp90: Friends, clients and natural foes.","publicationDate":"2016","journal":"Biochimie","firstPage":"227","lastPage":"240","volume":"127"},"referencePositions":["REVIEW"]},{"referenceNumber":70,"citation":{"id":"26991466","citationType":"journal article","authors":["Pearl L.H."],"citationCrossReferences":[{"database":"PubMed","id":"26991466"},{"database":"DOI","id":"10.1002/bip.22835"}],"title":"Review: The HSP90 molecular chaperone-an enigmatic ATPase.","publicationDate":"2016","journal":"Biopolymers","firstPage":"594","lastPage":"607","volume":"105"},"referencePositions":["REVIEW"]},{"referenceNumber":71,"citation":{"id":"27353360","citationType":"journal article","authors":["Woodford M.R.","Dunn D.M.","Blanden A.R.","Capriotti D.","Loiselle D.","Prodromou C.","Panaretou B.","Hughes P.F.","Smith A.","Ackerman W.","Haystead T.A.","Loh S.N.","Bourboulia D.","Schmidt L.S.","Marston Linehan W.","Bratslavsky G.","Mollapour M."],"citationCrossReferences":[{"database":"PubMed","id":"27353360"},{"database":"DOI","id":"10.1038/ncomms12037"}],"title":"The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.","publicationDate":"2016","journal":"Nat. Commun.","firstPage":"12037","lastPage":"12037","volume":"7"},"referencePositions":["FUNCTION","INTERACTION WITH FLCN; AHSA1; HSP70; CDC37; FNIP1; FNIP2; STUB1; STIP1; PTGES3 AND PPP5C"]},{"referenceNumber":72,"citation":{"id":"26754925","citationType":"journal article","authors":["Asano Y.","Kawase T.","Okabe A.","Tsutsumi S.","Ichikawa H.","Tatebe S.","Kitabayashi I.","Tashiro F.","Namiki H.","Kondo T.","Semba K.","Aburatani H.","Taya Y.","Nakagama H.","Ohki R."],"citationCrossReferences":[{"database":"PubMed","id":"26754925"},{"database":"DOI","id":"10.1038/srep19174"}],"title":"IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.","publicationDate":"2016","journal":"Sci. Rep.","firstPage":"19174","lastPage":"19174","volume":"6"},"referencePositions":["INTERACTION WITH HSF1"]},{"referenceNumber":73,"citation":{"id":"29127155","citationType":"journal article","authors":["Woodford M.R.","Sager R.A.","Marris E.","Dunn D.M.","Blanden A.R.","Murphy R.L.","Rensing N.","Shapiro O.","Panaretou B.","Prodromou C.","Loh S.N.","Gutmann D.H.","Bourboulia D.","Bratslavsky G.","Wong M.","Mollapour M."],"citationCrossReferences":[{"database":"PubMed","id":"29127155"},{"database":"DOI","id":"10.15252/embj.201796700"}],"title":"Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.","publicationDate":"2017","journal":"EMBO J.","firstPage":"3650","lastPage":"3665","volume":"36"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","IDENTIFICATION IN A COMPLEX WITH TSC1 AND TSC2","INTERACTION WITH TSC1 AND AHSA1","SUBUNIT","MUTAGENESIS OF GLU-47; ASP-93; TYR-313 AND 728-MET--ASP-732"]},{"referenceNumber":74,"citation":{"id":"30559449","citationType":"journal article","authors":["Normand S.","Waldschmitt N.","Neerincx A.","Martinez-Torres R.J.","Chauvin C.","Couturier-Maillard A.","Boulard O.","Cobret L.","Awad F.","Huot L.","Ribeiro-Ribeiro A.","Lautz K.","Ruez R.","Delacre M.","Bondu C.","Guilliams M.","Scott C.","Segal A.","Amselem S.","Hot D.","Karabina S.","Bohn E.","Ryffel B.","Poulin L.F.","Kufer T.A.","Chamaillard M."],"citationCrossReferences":[{"database":"PubMed","id":"30559449"},{"database":"DOI","id":"10.1038/s41467-018-07750-5"}],"title":"Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens.","publicationDate":"2018","journal":"Nat. Commun.","firstPage":"5338","lastPage":"5338","volume":"9"},"referencePositions":["INTERACTION WITH NLRP12"]},{"referenceNumber":75,"citation":{"id":"29743370","citationType":"journal article","authors":["Liu X.","Main D.","Ma Y.","He B."],"citationCrossReferences":[{"database":"PubMed","id":"29743370"},{"database":"DOI","id":"10.1128/jvi.00402-18"}],"title":"Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex.","publicationDate":"2018","journal":"J. Virol.","firstPage":"0","lastPage":"0","volume":"92"},"referencePositions":["INTERACTION WITH HERPES SIMPLEX VIRUS 1 PROTEIN US11 (MICROBIAL INFECTION)"]},{"referenceNumber":76,"citation":{"id":"41742417","citationType":"journal article","authors":["Kim S.S.","Ham S.","Boo S.H.","Lee D.","Min H.","Kang E.","Haque R.","Lee H.","Jung Y.","Kwon S.","Park S.","Park H.H.","Kim E.J.E.","Hwang W.","Kim E.","Lee G.Y.","Park K.Y.","Suh J.M.","Lee G.","Kim Y.K.","Lee S.V."],"citationCrossReferences":[{"database":"PubMed","id":"41742417"},{"database":"DOI","id":"10.1016/j.molcel.2026.01.031"}],"title":"Ribonuclease kappa promotes longevity by preventing age-associated accumulation of circular RNA in stress granules.","publicationDate":"2026","journal":"Mol. Cell","firstPage":"885","lastPage":"900.e14","volume":"86"},"referencePositions":["INTERACTION WITH RNASEK","SUBCELLULAR LOCATION"]},{"referenceNumber":77,"citation":{"id":"9108479","citationType":"journal article","authors":["Stebbins C.E.","Russo A.A.","Schneider C.","Rosen N.","Hartl F.U.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"9108479"},{"database":"DOI","id":"10.1016/s0092-8674(00)80203-2"}],"title":"Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.","publicationDate":"1997","journal":"Cell","firstPage":"239","lastPage":"250","volume":"89"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH GELDANAMYCIN"]},{"referenceNumber":78,"citation":{"id":"9817749","citationType":"journal article","authors":["Obermann W.M.","Sondermann H.","Russo A.A.","Pavletich N.P.","Hartl F.U."],"citationCrossReferences":[{"database":"PubMed","id":"9817749"},{"database":"DOI","id":"10.1083/jcb.143.4.901"}],"title":"In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.","publicationDate":"1998","journal":"J. Cell Biol.","firstPage":"901","lastPage":"910","volume":"143"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH ADP","CATALYTIC ACTIVITY","INTERACTION WITH PTGES3"]},{"referenceNumber":79,"citation":{"id":"16307917","citationType":"journal article","authors":["Zhang M.","Windheim M.","Roe S.M.","Peggie M.","Cohen P.","Prodromou C.","Pearl L.H."],"citationCrossReferences":[{"database":"PubMed","id":"16307917"},{"database":"DOI","id":"10.1016/j.molcel.2005.09.023"}],"title":"Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.","publicationDate":"2005","journal":"Mol. Cell","firstPage":"525","lastPage":"538","volume":"20"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH STUB1","INTERACTION WITH STUB1 AND UBE2N","MOTIF TPR REPEAT-BINDING"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X15183","properties":[{"key":"ProteinId","value":"CAA33259.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M27024","properties":[{"key":"ProteinId","value":"AAA63194.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ890082","properties":[{"key":"ProteinId","value":"CAI64495.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ890083","properties":[{"key":"ProteinId","value":"CAI64496.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ314871","properties":[{"key":"ProteinId","value":"ABC40730.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK056446","properties":[{"key":"ProteinId","value":"BAG51711.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291115","properties":[{"key":"ProteinId","value":"BAF83804.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291607","properties":[{"key":"ProteinId","value":"BAF84296.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL133223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471061","properties":[{"key":"ProteinId","value":"EAW81765.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X07270","properties":[{"key":"ProteinId","value":"CAA30255.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M30626","properties":[{"key":"ProteinId","value":"AAA36023.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC000987","properties":[{"key":"ProteinId","value":"AAH00987.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC121062","properties":[{"key":"ProteinId","value":"AAI21063.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D87666","properties":[{"key":"ProteinId","value":"BAA13430.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D87666","properties":[{"key":"ProteinId","value":"BAA13431.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS32160.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P07900-2"},{"database":"CCDS","id":"CCDS9967.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P07900-1"},{"database":"PIR","id":"A32319","properties":[{"key":"EntryName","value":"HHHU86"}]},{"database":"RefSeq","id":"NP_001017963.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001017963.3"}],"isoformId":"P07900-2"},{"database":"RefSeq","id":"NP_005339.3","properties":[{"key":"NucleotideSequenceId","value":"NM_005348.4"}],"isoformId":"P07900-1"},{"database":"PDB","id":"1BYQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"1OSF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=9-223"}]},{"database":"PDB","id":"1UY6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UY7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UY8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.98 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UY9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UYC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UYD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UYE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UYF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UYG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UYH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UYI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UYK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1UYL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"1YC1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"1YC3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.12 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"1YC4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.81 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"1YER","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"1YES","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"1YET","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2BSM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"2BT0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=2-236"}]},{"database":"PDB","id":"2BUG","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=728-732"}]},{"database":"PDB","id":"2BYH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"2BYI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"2BZ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=2-236"}]},{"database":"PDB","id":"2C2L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"E/F/G/H=724-732"}]},{"database":"PDB","id":"2CCS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2CCT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2CCU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2FWY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2FWZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2H55","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2JJC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A=8-223"}]},{"database":"PDB","id":"2K5B","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=14-223"}]},{"database":"PDB","id":"2QF6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/C/D=17-223"}]},{"database":"PDB","id":"2QFO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.68 A"},{"key":"Chains","value":"A/B=17-223"}]},{"database":"PDB","id":"2QG0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=17-223"}]},{"database":"PDB","id":"2QG2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=17-223"}]},{"database":"PDB","id":"2UWD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2VCI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2VCJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2WI1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2WI2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"A/B=1-236"}]},{"database":"PDB","id":"2WI3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2WI4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2WI5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2WI6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.18 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2WI7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"2XAB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"2XDK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.97 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2XDL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.98 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2XDS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.97 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2XDU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"A=14-224"}]},{"database":"PDB","id":"2XDX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.42 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2XHR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2XHT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.27 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2XHX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2XJG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2XJJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"2XJX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2XK2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YE2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YE3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YE4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YE5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.73 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YE6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.56 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YE7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YE8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YE9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YEA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.73 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YEB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YEC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YED","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YEE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YEF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YEG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"2YEH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YEI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YEJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"2YI0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1-229"}]},{"database":"PDB","id":"2YI5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-229"}]},{"database":"PDB","id":"2YI6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-229"}]},{"database":"PDB","id":"2YI7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=1-229"}]},{"database":"PDB","id":"2YJW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.61 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"2YJX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.83 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"2YK2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"2YK9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.32 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"2YKB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.93 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"2YKC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"2YKE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.43 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"2YKI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"2YKJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.46 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"3B24","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"3B25","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3B26","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"3B27","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3B28","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"3BM9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=10-236"}]},{"database":"PDB","id":"3BMY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=10-236"}]},{"database":"PDB","id":"3D0B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"A=1-232"}]},{"database":"PDB","id":"3EKO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3EKR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3FT5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3FT8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3HEK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3HHU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A/B=1-224"}]},{"database":"PDB","id":"3HYY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3HYZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"3HZ1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3HZ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3INW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A=10-236"}]},{"database":"PDB","id":"3INX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=10-236"}]},{"database":"PDB","id":"3K97","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3K98","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3K99","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=9-225"}]},{"database":"PDB","id":"3MNR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"P=1-232"}]},{"database":"PDB","id":"3O0I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.47 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"3OW6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=17-223"}]},{"database":"PDB","id":"3OWB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=17-223"}]},{"database":"PDB","id":"3OWD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.63 A"},{"key":"Chains","value":"A=17-223"}]},{"database":"PDB","id":"3Q6M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C=293-732"}]},{"database":"PDB","id":"3Q6N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"A/B/C/D/E/F=293-732"}]},{"database":"PDB","id":"3QDD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"3QTF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A=10-236"}]},{"database":"PDB","id":"3R4M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3R4N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3R4O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3R4P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3R91","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A=10-236"}]},{"database":"PDB","id":"3R92","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A=10-236"}]},{"database":"PDB","id":"3RKZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A=10-236"}]},{"database":"PDB","id":"3RLP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3RLQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3RLR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=9-225"}]},{"database":"PDB","id":"3T0H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.20 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3T0Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.19 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3T10","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.24 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3T1K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"3T2S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"3TUH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=16-224"}]},{"database":"PDB","id":"3VHA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.39 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3VHC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.41 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"3VHD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"3WHA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"3WQ9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"4AIF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"D/E=726-732"}]},{"database":"PDB","id":"4AWO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"4AWP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"4AWQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"4B7P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4BQG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4BQJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4CGQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"Q=726-732"}]},{"database":"PDB","id":"4CGU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.11 A"},{"key":"Chains","value":"C=726-732"}]},{"database":"PDB","id":"4CGV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.54 A"},{"key":"Chains","value":"E/F=726-732"}]},{"database":"PDB","id":"4CGW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"C/D=726-732"}]},{"database":"PDB","id":"4CWF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4CWN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4CWO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.31 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4CWP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4CWQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4CWR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4CWS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4CWT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4EEH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4EFT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.12 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4EFU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4EGH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4EGI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4EGK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4FCP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=1-236"}]},{"database":"PDB","id":"4FCQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"4FCR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"4HY6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4JQL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.72 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4L8Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4L90","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4L91","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4L93","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.84 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"4L94","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4LWE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=17-224"}]},{"database":"PDB","id":"4LWF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=17-224"}]},{"database":"PDB","id":"4LWG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=17-224"}]},{"database":"PDB","id":"4LWH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=16-224"}]},{"database":"PDB","id":"4LWI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=17-224"}]},{"database":"PDB","id":"4NH7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"4NH8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4O04","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4O05","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4O07","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4O09","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.96 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4O0B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.93 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4R3M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=16-224"}]},{"database":"PDB","id":"4U93","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"4W7T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"4XIP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4XIQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.84 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4XIR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4XIT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"4YKQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.91 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"4YKR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.61 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"4YKT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"4YKU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"4YKW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=2-236"}]},{"database":"PDB","id":"4YKX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"4YKY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.78 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"4YKZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"5CF0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5FNC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"5FND","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"5FNF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"5GGZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.02 A"},{"key":"Chains","value":"A/B/C/D=16-225"}]},{"database":"PDB","id":"5J20","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.76 A"},{"key":"Chains","value":"A=17-223"}]},{"database":"PDB","id":"5J27","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=16-224"}]},{"database":"PDB","id":"5J2V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A=17-223"}]},{"database":"PDB","id":"5J2X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.22 A"},{"key":"Chains","value":"A=17-224"}]},{"database":"PDB","id":"5J64","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5J6L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5J6M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.64 A"},{"key":"Chains","value":"A=9-234"}]},{"database":"PDB","id":"5J6N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=9-234"}]},{"database":"PDB","id":"5J80","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.17 A"},{"key":"Chains","value":"A=9-233"}]},{"database":"PDB","id":"5J82","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.17 A"},{"key":"Chains","value":"A=9-233"}]},{"database":"PDB","id":"5J86","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.87 A"},{"key":"Chains","value":"A=9-233"}]},{"database":"PDB","id":"5J8M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=9-233"}]},{"database":"PDB","id":"5J8U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=9-233"}]},{"database":"PDB","id":"5J9X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=9-233"}]},{"database":"PDB","id":"5LNY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5LNZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.54 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5LO0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5LO1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5LO5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5LO6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5LQ9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=17-223"}]},{"database":"PDB","id":"5LR1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"5LR7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"5LRL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.33 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"5LRZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"5LS1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=17-223"}]},{"database":"PDB","id":"5M4E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5M4H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5NYH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5NYI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A=9-235"}]},{"database":"PDB","id":"5OCI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.62 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5OD7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5ODX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5T21","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=18-223"}]},{"database":"PDB","id":"5VYY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"5XQD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5XQE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5XR5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5XR9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5XRB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5XRD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5XRE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"5ZR3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/C/E/G=1-236"}]},{"database":"PDB","id":"6B99","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6B9A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/B=1-236"}]},{"database":"PDB","id":"6CEO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6CYG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=1-236"}]},{"database":"PDB","id":"6CYH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.49 A"},{"key":"Chains","value":"A/B=1-236"}]},{"database":"PDB","id":"6EI5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=15-223"}]},{"database":"PDB","id":"6EL5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6ELN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=17-223"}]},{"database":"PDB","id":"6ELO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6ELP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6EY8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.16 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6EY9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6EYA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6EYB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6F1N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6FCJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.49 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"6FDP","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=724-732"}]},{"database":"PDB","id":"6GP4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GP8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GPF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GPH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.56 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GPO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.48 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GPP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.51 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GPR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GPT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GPW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GPY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GQ6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GQR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GQS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.43 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GQU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.72 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GR1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GR3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GR4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6GR5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.34 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6HHR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=17-224"}]},{"database":"PDB","id":"6KSQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=293-554"}]},{"database":"PDB","id":"6LR9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"6LSZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"6LT8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"6LTI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"6LTK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.14 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"6N8X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.49 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6OLX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"6TN4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.27 A"},{"key":"Chains","value":"AAA=9-236"}]},{"database":"PDB","id":"6TN5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.17 A"},{"key":"Chains","value":"AAA=9-236"}]},{"database":"PDB","id":"6U98","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"6U99","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"6U9A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"6U9B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"7DMC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.34 A"},{"key":"Chains","value":"A=16-224"}]},{"database":"PDB","id":"7H9K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.42 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.49 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.64 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.51 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9R","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.17 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.48 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.94 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.64 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.47 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.11 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7H9Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.06 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.47 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.46 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.73 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.98 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.61 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.27 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.22 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HA9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.68 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.73 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.61 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.72 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.77 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.61 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.83 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.77 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.08 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.04 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.29 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.27 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HAZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.68 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.78 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.34 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.87 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.98 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HB9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.84 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.97 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.14 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.21 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.07 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.91 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.73 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.91 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.56 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.91 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HBZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HC0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HC1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.13 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HC2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7HC3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.22 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"7KRJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.56 A"},{"key":"Chains","value":"A/B=1-732"}]},{"database":"PDB","id":"7KW7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.57 A"},{"key":"Chains","value":"A/B=1-732"}]},{"database":"PDB","id":"7L7I","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A/B=1-732"}]},{"database":"PDB","id":"7L7J","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B=1-732"}]},{"database":"PDB","id":"7LSZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1-293"}]},{"database":"PDB","id":"7LT0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1-293"}]},{"database":"PDB","id":"7RXZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.15 A"},{"key":"Chains","value":"A/B/C/D/E/F=293-714"}]},{"database":"PDB","id":"7RY0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B=293-714"}]},{"database":"PDB","id":"7RY1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.52 A"},{"key":"Chains","value":"A/B/C=293-714"}]},{"database":"PDB","id":"7S8Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7S8Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.64 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7S90","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7S95","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.71 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7S98","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7S99","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7S9F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7S9G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7S9H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7S9I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"7UR3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1-293"}]},{"database":"PDB","id":"8AGI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=1-236"}]},{"database":"PDB","id":"8AGJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.32 A"},{"key":"Chains","value":"A/B=1-236"}]},{"database":"PDB","id":"8AGL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B=1-236"}]},{"database":"PDB","id":"8B7I","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"8B7J","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"8FFV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.01 A"},{"key":"Chains","value":"A/B=2-732"}]},{"database":"PDB","id":"8FFW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.23 A"},{"key":"Chains","value":"A/B=2-732"}]},{"database":"PDB","id":"8JR6","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-237"}]},{"database":"PDB","id":"8JR7","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-237"}]},{"database":"PDB","id":"8JRA","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-237"}]},{"database":"PDB","id":"8KI4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"8SBT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"8W4V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.81 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"8W8K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A/B=9-236"}]},{"database":"PDB","id":"8X2R","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"PDB","id":"9AUU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=2-236"}]},{"database":"PDB","id":"9IMW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"A=9-236"}]},{"database":"PDB","id":"9KMR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.98 A"},{"key":"Chains","value":"A/B=1-732"}]},{"database":"PDB","id":"9KOX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.43 A"},{"key":"Chains","value":"A/B=1-732"}]},{"database":"PDB","id":"9KQN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.84 A"},{"key":"Chains","value":"A/B=1-732"}]},{"database":"PDB","id":"9QQU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.13 A"},{"key":"Chains","value":"B=728-732"}]},{"database":"PDB","id":"9X6X","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-237"}]},{"database":"PDB","id":"9X70","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-237"}]},{"database":"PDB","id":"9X71","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-237"}]},{"database":"PDB","id":"9X72","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-237"}]},{"database":"PDB","id":"9X73","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-237"}]},{"database":"PDB","id":"9XZ1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.96 A"},{"key":"Chains","value":"A=1-236"}]},{"database":"AlphaFoldDB","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23004","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23005","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23006","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23050","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23213","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23214","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29068","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29069","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29949","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29957","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29973","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29976","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-5981","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62442","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62482","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62508","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-73359","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109552","properties":[{"key":"Interactions","value":"1399"}]},{"database":"ComplexPortal","id":"CPX-3288","properties":[{"key":"EntryName","value":"HSP90A-CDC37 chaperone complex"}]},{"database":"CORUM","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-27595N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P07900","properties":[{"key":"Number of interactors","value":"2774"}]},{"database":"IntAct","id":"P07900","properties":[{"key":"Interactions","value":"469"}]},{"database":"NDEx","id":"IQUERY-CP-HSP90AA1","properties":[{"key":"Evidences","value":"34 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000335153","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3880","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB07317","properties":[{"key":"GenericName","value":"(3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one"}]},{"database":"DrugBank","id":"DB08197","properties":[{"key":"GenericName","value":"(5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime"}]},{"database":"DrugBank","id":"DB08443","properties":[{"key":"GenericName","value":"2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol"}]},{"database":"DrugBank","id":"DB08557","properties":[{"key":"GenericName","value":"2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide"}]},{"database":"DrugBank","id":"DB08789","properties":[{"key":"GenericName","value":"2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE"}]},{"database":"DrugBank","id":"DB06969","properties":[{"key":"GenericName","value":"2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide"}]},{"database":"DrugBank","id":"DB08788","properties":[{"key":"GenericName","value":"3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE"}]},{"database":"DrugBank","id":"DB07324","properties":[{"key":"GenericName","value":"3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE"}]},{"database":"DrugBank","id":"DB02840","properties":[{"key":"GenericName","value":"4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid"}]},{"database":"DrugBank","id":"DB03749","properties":[{"key":"GenericName","value":"4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole"}]},{"database":"DrugBank","id":"DB08787","properties":[{"key":"GenericName","value":"4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine"}]},{"database":"DrugBank","id":"DB08786","properties":[{"key":"GenericName","value":"4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine"}]},{"database":"DrugBank","id":"DB07502","properties":[{"key":"GenericName","value":"4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol"}]},{"database":"DrugBank","id":"DB07100","properties":[{"key":"GenericName","value":"4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL"}]},{"database":"DrugBank","id":"DB06957","properties":[{"key":"GenericName","value":"4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL"}]},{"database":"DrugBank","id":"DB07601","properties":[{"key":"GenericName","value":"4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol"}]},{"database":"DrugBank","id":"DB08194","properties":[{"key":"GenericName","value":"4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine"}]},{"database":"DrugBank","id":"DB08442","properties":[{"key":"GenericName","value":"4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol"}]},{"database":"DrugBank","id":"DB07495","properties":[{"key":"GenericName","value":"5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE"}]},{"database":"DrugBank","id":"DB06964","properties":[{"key":"GenericName","value":"5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE"}]},{"database":"DrugBank","id":"DB06961","properties":[{"key":"GenericName","value":"5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide"}]},{"database":"DrugBank","id":"DB06958","properties":[{"key":"GenericName","value":"5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE"}]},{"database":"DrugBank","id":"DB07319","properties":[{"key":"GenericName","value":"6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE"}]},{"database":"DrugBank","id":"DB03137","properties":[{"key":"GenericName","value":"8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine"}]},{"database":"DrugBank","id":"DB03093","properties":[{"key":"GenericName","value":"8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine"}]},{"database":"DrugBank","id":"DB02550","properties":[{"key":"GenericName","value":"8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine"}]},{"database":"DrugBank","id":"DB04505","properties":[{"key":"GenericName","value":"8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine"}]},{"database":"DrugBank","id":"DB07877","properties":[{"key":"GenericName","value":"8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE"}]},{"database":"DrugBank","id":"DB04254","properties":[{"key":"GenericName","value":"8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine"}]},{"database":"DrugBank","id":"DB08436","properties":[{"key":"GenericName","value":"8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H"}]},{"database":"DrugBank","id":"DB04054","properties":[{"key":"GenericName","value":"9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine"}]},{"database":"DrugBank","id":"DB02359","properties":[{"key":"GenericName","value":"9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine"}]},{"database":"DrugBank","id":"DB03504","properties":[{"key":"GenericName","value":"9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine"}]},{"database":"DrugBank","id":"DB02754","properties":[{"key":"GenericName","value":"9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine"}]},{"database":"DrugBank","id":"DB03809","properties":[{"key":"GenericName","value":"9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine"}]},{"database":"DrugBank","id":"DB03899","properties":[{"key":"GenericName","value":"9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine"}]},{"database":"DrugBank","id":"DB12442","properties":[{"key":"GenericName","value":"Alvespimycin"}]},{"database":"DrugBank","id":"DB01025","properties":[{"key":"GenericName","value":"Amlexanox"}]},{"database":"DrugBank","id":"DB12359","properties":[{"key":"GenericName","value":"BIIB021"}]},{"database":"DrugBank","id":"DB07594","properties":[{"key":"GenericName","value":"CCT-018159"}]},{"database":"DrugBank","id":"DB09130","properties":[{"key":"GenericName","value":"Copper"}]},{"database":"DrugBank","id":"DB01003","properties":[{"key":"GenericName","value":"Cromoglicic acid"}]},{"database":"DrugBank","id":"DB02424","properties":[{"key":"GenericName","value":"Geldanamycin"}]},{"database":"DrugBank","id":"DB13023","properties":[{"key":"GenericName","value":"IPI-493"}]},{"database":"DrugBank","id":"DB06956","properties":[{"key":"GenericName","value":"N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE"}]},{"database":"DrugBank","id":"DB07325","properties":[{"key":"GenericName","value":"N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE"}]},{"database":"DrugBank","id":"DB04588","properties":[{"key":"GenericName","value":"N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE"}]},{"database":"DrugBank","id":"DB06306","properties":[{"key":"GenericName","value":"Onalespib"}]},{"database":"DrugBank","id":"DB09221","properties":[{"key":"GenericName","value":"Polaprezinc"}]},{"database":"DrugBank","id":"DB04216","properties":[{"key":"GenericName","value":"Quercetin"}]},{"database":"DrugBank","id":"DB03758","properties":[{"key":"GenericName","value":"Radicicol"}]},{"database":"DrugBank","id":"DB13174","properties":[{"key":"GenericName","value":"Rhein"}]},{"database":"DrugBank","id":"DB00615","properties":[{"key":"GenericName","value":"Rifabutin"}]},{"database":"DrugBank","id":"DB17055","properties":[{"key":"GenericName","value":"SNX-2112"}]},{"database":"DrugBank","id":"DB06070","properties":[{"key":"GenericName","value":"SNX-5422"}]},{"database":"DrugBank","id":"DB05134","properties":[{"key":"GenericName","value":"Tanespimycin"}]},{"database":"DrugCentral","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"2905","properties":[{"key":"Description","value":"-"}]},{"database":"MoonDB","id":"P07900","properties":[{"key":"Type","value":"Predicted"}]},{"database":"CarbonylDB","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P07900","properties":[{"key":"glycosylation","value":"1 N-Linked glycan (1 site)"}]},{"database":"GlyCosmos","id":"P07900","properties":[{"key":"glycosylation","value":"2 sites, 3 glycans"}]},{"database":"GlyGen","id":"P07900","properties":[{"key":"glycosylation","value":"3 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HSP90AA1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"92090606","properties":[{"key":"Description","value":"-"}]},{"database":"OGP","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"IPI00784295","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000335153","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"PRIDE","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52031","properties":[{"key":"Description","value":"-"}],"isoformId":"P07900-1"},{"database":"ProteomicsDB","id":"52032","properties":[{"key":"Description","value":"-"}],"isoformId":"P07900-2"},{"database":"Pumba","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P07900-1","properties":[{"key":"Description","value":"-"}],"isoformId":"P07900-1"},{"database":"Antibodypedia","id":"3676","properties":[{"key":"antibodies","value":"1927 antibodies from 49 providers"}]},{"database":"DNASU","id":"3320","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000216281.13","properties":[{"key":"ProteinId","value":"ENSP00000216281.8"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-1"},{"database":"Ensembl","id":"ENST00000334701.11","properties":[{"key":"ProteinId","value":"ENSP00000335153.7"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-2"},{"database":"Ensembl","id":"ENST00000877282.1","properties":[{"key":"ProteinId","value":"ENSP00000547341.1"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-1"},{"database":"Ensembl","id":"ENST00000877283.1","properties":[{"key":"ProteinId","value":"ENSP00000547342.1"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-1"},{"database":"Ensembl","id":"ENST00000877284.1","properties":[{"key":"ProteinId","value":"ENSP00000547343.1"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-1"},{"database":"Ensembl","id":"ENST00000877286.1","properties":[{"key":"ProteinId","value":"ENSP00000547345.1"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-1"},{"database":"Ensembl","id":"ENST00000922308.1","properties":[{"key":"ProteinId","value":"ENSP00000592367.1"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-1"},{"database":"Ensembl","id":"ENST00000922309.1","properties":[{"key":"ProteinId","value":"ENSP00000592368.1"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-1"},{"database":"Ensembl","id":"ENST00000922311.1","properties":[{"key":"ProteinId","value":"ENSP00000592370.1"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-1"},{"database":"Ensembl","id":"ENST00000922312.1","properties":[{"key":"ProteinId","value":"ENSP00000592371.1"},{"key":"GeneId","value":"ENSG00000080824.20"}],"isoformId":"P07900-1"},{"database":"GeneID","id":"3320","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3320","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000216281.13","properties":[{"key":"ProteinId","value":"ENSP00000216281.8"},{"key":"RefSeqNucleotideId","value":"NM_005348.4"},{"key":"RefSeqProteinId","value":"NP_005339.3"}]},{"database":"UCSC","id":"uc001yku.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P07900-1"},{"database":"AGR","id":"HGNC:5253","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29519","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3320","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3320","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HSP90AA1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5253","properties":[{"key":"GeneName","value":"HSP90AA1"}]},{"database":"HPA","id":"ENSG00000080824","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"HSP90AA1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"140571","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000080824","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000080824","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0019","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01020000230401","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_006684_1_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACNCICL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5426351at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P07900","properties":[{"key":"Number of GO annotations","value":"13 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"5.6.1.10","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1227986","properties":[{"key":"PathwayName","value":"Signaling by ERBB2"}]},{"database":"Reactome","id":"R-HSA-1236382","properties":[{"key":"PathwayName","value":"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants"}]},{"database":"Reactome","id":"R-HSA-1474151","properties":[{"key":"PathwayName","value":"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"}]},{"database":"Reactome","id":"R-HSA-168928","properties":[{"key":"PathwayName","value":"DDX58/IFIH1-mediated induction of interferon-alpha/beta"}]},{"database":"Reactome","id":"R-HSA-192905","properties":[{"key":"PathwayName","value":"vRNP Assembly"}]},{"database":"Reactome","id":"R-HSA-2029482","properties":[{"key":"PathwayName","value":"Regulation of actin dynamics for phagocytic cup formation"}]},{"database":"Reactome","id":"R-HSA-203615","properties":[{"key":"PathwayName","value":"eNOS activation"}]},{"database":"Reactome","id":"R-HSA-2565942","properties":[{"key":"PathwayName","value":"Regulation of PLK1 Activity at G2/M Transition"}]},{"database":"Reactome","id":"R-HSA-3000484","properties":[{"key":"PathwayName","value":"Scavenging by Class F Receptors"}]},{"database":"Reactome","id":"R-HSA-3371497","properties":[{"key":"PathwayName","value":"HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"}]},{"database":"Reactome","id":"R-HSA-3371511","properties":[{"key":"PathwayName","value":"HSF1 activation"}]},{"database":"Reactome","id":"R-HSA-3371568","properties":[{"key":"PathwayName","value":"Attenuation phase"}]},{"database":"Reactome","id":"R-HSA-3371571","properties":[{"key":"PathwayName","value":"HSF1-dependent transactivation"}]},{"database":"Reactome","id":"R-HSA-380259","properties":[{"key":"PathwayName","value":"Loss of Nlp from mitotic centrosomes"}]},{"database":"Reactome","id":"R-HSA-380270","properties":[{"key":"PathwayName","value":"Recruitment of mitotic centrosome proteins and complexes"}]},{"database":"Reactome","id":"R-HSA-380284","properties":[{"key":"PathwayName","value":"Loss of proteins required for interphase microtubule organization from the centrosome"}]},{"database":"Reactome","id":"R-HSA-380320","properties":[{"key":"PathwayName","value":"Recruitment of NuMA to mitotic centrosomes"}]},{"database":"Reactome","id":"R-HSA-399954","properties":[{"key":"PathwayName","value":"Sema3A PAK dependent Axon repulsion"}]},{"database":"Reactome","id":"R-HSA-4420097","properties":[{"key":"PathwayName","value":"VEGFA-VEGFR2 Pathway"}]},{"database":"Reactome","id":"R-HSA-5218920","properties":[{"key":"PathwayName","value":"VEGFR2 mediated vascular permeability"}]},{"database":"Reactome","id":"R-HSA-5336415","properties":[{"key":"PathwayName","value":"Uptake and function of diphtheria toxin"}]},{"database":"Reactome","id":"R-HSA-5601884","properties":[{"key":"PathwayName","value":"PIWI-interacting RNA (piRNA) biogenesis"}]},{"database":"Reactome","id":"R-HSA-5620912","properties":[{"key":"PathwayName","value":"Anchoring of the basal body to the plasma membrane"}]},{"database":"Reactome","id":"R-HSA-5637810","properties":[{"key":"PathwayName","value":"Constitutive Signaling by EGFRvIII"}]},{"database":"Reactome","id":"R-HSA-5675482","properties":[{"key":"PathwayName","value":"Regulation of necroptotic cell death"}]},{"database":"Reactome","id":"R-HSA-6785807","properties":[{"key":"PathwayName","value":"Interleukin-4 and Interleukin-13 signaling"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-HSA-8852276","properties":[{"key":"PathwayName","value":"The role of GTSE1 in G2/M progression after G2 checkpoint"}]},{"database":"Reactome","id":"R-HSA-8854518","properties":[{"key":"PathwayName","value":"AURKA Activation by TPX2"}]},{"database":"Reactome","id":"R-HSA-8863795","properties":[{"key":"PathwayName","value":"Downregulation of ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-8939211","properties":[{"key":"PathwayName","value":"ESR-mediated signaling"}]},{"database":"Reactome","id":"R-HSA-9009391","properties":[{"key":"PathwayName","value":"Extra-nuclear estrogen signaling"}]},{"database":"Reactome","id":"R-HSA-9013418","properties":[{"key":"PathwayName","value":"RHOBTB2 GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9018519","properties":[{"key":"PathwayName","value":"Estrogen-dependent gene expression"}]},{"database":"Reactome","id":"R-HSA-9613829","properties":[{"key":"PathwayName","value":"Chaperone Mediated Autophagy"}]},{"database":"Reactome","id":"R-HSA-9634285","properties":[{"key":"PathwayName","value":"Constitutive Signaling by Overexpressed ERBB2"}]},{"database":"Reactome","id":"R-HSA-9646399","properties":[{"key":"PathwayName","value":"Aggrephagy"}]},{"database":"Reactome","id":"R-HSA-9652282","properties":[{"key":"PathwayName","value":"Drug-mediated inhibition of ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-9664565","properties":[{"key":"PathwayName","value":"Signaling by ERBB2 KD Mutants"}]},{"database":"Reactome","id":"R-HSA-9665233","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to trastuzumab"}]},{"database":"Reactome","id":"R-HSA-9665244","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to sapitinib"}]},{"database":"Reactome","id":"R-HSA-9665245","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to tesevatinib"}]},{"database":"Reactome","id":"R-HSA-9665246","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to neratinib"}]},{"database":"Reactome","id":"R-HSA-9665247","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to osimertinib"}]},{"database":"Reactome","id":"R-HSA-9665249","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to afatinib"}]},{"database":"Reactome","id":"R-HSA-9665250","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to AEE788"}]},{"database":"Reactome","id":"R-HSA-9665251","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to lapatinib"}]},{"database":"Reactome","id":"R-HSA-9665348","properties":[{"key":"PathwayName","value":"Signaling by ERBB2 ECD mutants"}]},{"database":"Reactome","id":"R-HSA-9665686","properties":[{"key":"PathwayName","value":"Signaling by ERBB2 TMD/JMD mutants"}]},{"database":"Reactome","id":"R-HSA-9665737","properties":[{"key":"PathwayName","value":"Drug resistance in ERBB2 TMD/JMD mutants"}]},{"database":"Reactome","id":"R-HSA-9679191","properties":[{"key":"PathwayName","value":"Potential therapeutics for SARS"}]},{"database":"Reactome","id":"R-HSA-9705671","properties":[{"key":"PathwayName","value":"SARS-CoV-2 activates/modulates innate and adaptive immune responses"}]},{"database":"Reactome","id":"R-HSA-9820962","properties":[{"key":"PathwayName","value":"Assembly and release of respiratory syncytial virus (RSV) virions"}]},{"database":"Reactome","id":"R-HSA-9834752","properties":[{"key":"PathwayName","value":"Respiratory syncytial virus genome replication"}]},{"database":"Reactome","id":"R-HSA-9920588","properties":[{"key":"PathwayName","value":"Dengue virus activates/modulates innate and adaptive immune responses"}]},{"database":"SignaLink","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000080824","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3320","properties":[{"key":"hits","value":"39 hits in 1173 CRISPR screens"}]},{"database":"CD-CODE","id":"232F8A39","properties":[{"key":"EntryName","value":"P-body"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"B5B9A610","properties":[{"key":"EntryName","value":"PML body"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"HSP90AA1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P07900","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3320","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P07900","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P07900","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"RNAct","id":"P07900","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000080824","properties":[{"key":"ExpressionPatterns","value":"Expressed in Brodmann (1909) area 23 and 218 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P07900","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0044295","properties":[{"key":"GoTerm","value":"C:axonal growth cone"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0016323","properties":[{"key":"GoTerm","value":"C:basolateral plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031526","properties":[{"key":"GoTerm","value":"C:brush border membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10791971"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0044294","properties":[{"key":"GoTerm","value":"C:dendritic growth cone"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0071682","properties":[{"key":"GoTerm","value":"C:endocytic vesicle lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"11487543"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"12519789"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19199708"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:1904813","properties":[{"key":"GoTerm","value":"C:ficolin-1-rich granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:1990565","properties":[{"key":"GoTerm","value":"C:HSP90-CDC37 chaperone complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19073599"}]},{"database":"GO","id":"GO:0043202","properties":[{"key":"GoTerm","value":"C:lysosomal lumen"},{"key":"GoEvidenceType","value":"TAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"25719862"}]},{"database":"GO","id":"GO:0042470","properties":[{"key":"GoTerm","value":"C:melanosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17081065"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25609812"}]},{"database":"GO","id":"GO:0043209","properties":[{"key":"GoTerm","value":"C:myelin sheath"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"21630459"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11276205"}]},{"database":"GO","id":"GO:0101031","properties":[{"key":"GoTerm","value":"C:protein folding chaperone complex"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25719862"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23349634"}]},{"database":"GO","id":"GO:0034774","properties":[{"key":"GoTerm","value":"C:secretory granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0097226","properties":[{"key":"GoTerm","value":"C:sperm mitochondrial sheath"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097524","properties":[{"key":"GoTerm","value":"C:sperm plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27353360"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15937123"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29127155"}]},{"database":"GO","id":"GO:0140662","properties":[{"key":"GoTerm","value":"F:ATP-dependent protein folding chaperone"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0002135","properties":[{"key":"GoTerm","value":"F:CTP binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032564","properties":[{"key":"GoTerm","value":"F:dATP binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097718","properties":[{"key":"GoTerm","value":"F:disordered domain specific binding"},{"key":"GoEvidenceType","value":"IPI:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15713458"}]},{"database":"GO","id":"GO:0070182","properties":[{"key":"GoTerm","value":"F:DNA polymerase binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10197982"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19751963"}]},{"database":"GO","id":"GO:0140767","properties":[{"key":"GoTerm","value":"F:enzyme-substrate adaptor activity"},{"key":"GoEvidenceType","value":"EXP:Reactome"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11988487"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12799359"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051020","properties":[{"key":"GoTerm","value":"F:GTPase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24337748"}]},{"database":"GO","id":"GO:0042826","properties":[{"key":"GoTerm","value":"F:histone deacetylase binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16809764"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29127155"}]},{"database":"GO","id":"GO:0023026","properties":[{"key":"GoTerm","value":"F:MHC class II protein complex binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0003729","properties":[{"key":"GoTerm","value":"F:mRNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030235","properties":[{"key":"GoTerm","value":"F:nitric-oxide synthase regulator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15937123"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29127155"}]},{"database":"GO","id":"GO:0019903","properties":[{"key":"GoTerm","value":"F:protein phosphatase binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1990782","properties":[{"key":"GoTerm","value":"F:protein tyrosine kinase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20353823"}]},{"database":"GO","id":"GO:0051022","properties":[{"key":"GoTerm","value":"F:Rho GDP-dissociation inhibitor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22681889"}]},{"database":"GO","id":"GO:0097110","properties":[{"key":"GoTerm","value":"F:scaffold protein binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10409742"}]},{"database":"GO","id":"GO:0017098","properties":[{"key":"GoTerm","value":"F:sulfonylurea receptor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048156","properties":[{"key":"GoTerm","value":"F:tau protein binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19363271"}]},{"database":"GO","id":"GO:0030911","properties":[{"key":"GoTerm","value":"F:TPR domain binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9660753"}]},{"database":"GO","id":"GO:0044325","properties":[{"key":"GoTerm","value":"F:transmembrane transporter binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16207813"}]},{"database":"GO","id":"GO:0002134","properties":[{"key":"GoTerm","value":"F:UTP binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002218","properties":[{"key":"GoTerm","value":"P:activation of innate immune response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20628368"}]},{"database":"GO","id":"GO:0010659","properties":[{"key":"GoTerm","value":"P:cardiac muscle cell apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034605","properties":[{"key":"GoTerm","value":"P:cellular response to heat"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070301","properties":[{"key":"GoTerm","value":"P:cellular response to hydrogen peroxide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071456","properties":[{"key":"GoTerm","value":"P:cellular response to hypoxia"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071222","properties":[{"key":"GoTerm","value":"P:cellular response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071260","properties":[{"key":"GoTerm","value":"P:cellular response to mechanical stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0036120","properties":[{"key":"GoTerm","value":"P:cellular response to platelet-derived growth factor stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0098586","properties":[{"key":"GoTerm","value":"P:cellular response to virus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25609812"}]},{"database":"GO","id":"GO:0061684","properties":[{"key":"GoTerm","value":"P:chaperone-mediated autophagy"},{"key":"GoEvidenceType","value":"TAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"25719862"}]},{"database":"GO","id":"GO:0051131","properties":[{"key":"GoTerm","value":"P:chaperone-mediated protein complex assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15644312"}]},{"database":"GO","id":"GO:0006839","properties":[{"key":"GoTerm","value":"P:mitochondrial transport"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"12526792"}]},{"database":"GO","id":"GO:0010664","properties":[{"key":"GoTerm","value":"P:negative regulation of striated muscle cell apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1902988","properties":[{"key":"GoTerm","value":"P:neurofibrillary tangle assembly"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19363271"}]},{"database":"GO","id":"GO:0001764","properties":[{"key":"GoTerm","value":"P:neuron migration"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046209","properties":[{"key":"GoTerm","value":"P:nitric oxide metabolic process"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0060452","properties":[{"key":"GoTerm","value":"P:positive regulation of cardiac muscle contraction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045793","properties":[{"key":"GoTerm","value":"P:positive regulation of cell size"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002230","properties":[{"key":"GoTerm","value":"P:positive regulation of defense response to virus by host"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20628368"}]},{"database":"GO","id":"GO:0032728","properties":[{"key":"GoTerm","value":"P:positive regulation of interferon-beta production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20628368"}]},{"database":"GO","id":"GO:0010592","properties":[{"key":"GoTerm","value":"P:positive regulation of lamellipodium assembly"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045429","properties":[{"key":"GoTerm","value":"P:positive regulation of nitric oxide biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045732","properties":[{"key":"GoTerm","value":"P:positive regulation of protein catabolic process"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"18292230"}]},{"database":"GO","id":"GO:0042307","properties":[{"key":"GoTerm","value":"P:positive regulation of protein import into nucleus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032273","properties":[{"key":"GoTerm","value":"P:positive regulation of protein polymerization"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19363271"}]},{"database":"GO","id":"GO:0032212","properties":[{"key":"GoTerm","value":"P:positive regulation of telomere maintenance via telomerase"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"19740745"}]},{"database":"GO","id":"GO:0006457","properties":[{"key":"GoTerm","value":"P:protein folding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030150","properties":[{"key":"GoTerm","value":"P:protein import into mitochondrial matrix"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15644312"}]},{"database":"GO","id":"GO:0051604","properties":[{"key":"GoTerm","value":"P:protein maturation"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27339980"}]},{"database":"GO","id":"GO:0042026","properties":[{"key":"GoTerm","value":"P:protein refolding"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9660753"}]},{"database":"GO","id":"GO:0050821","properties":[{"key":"GoTerm","value":"P:protein stabilization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27353360"}]},{"database":"GO","id":"GO:0043335","properties":[{"key":"GoTerm","value":"P:protein unfolding"},{"key":"GoEvidenceType","value":"NAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20176123"}]},{"database":"GO","id":"GO:0042981","properties":[{"key":"GoTerm","value":"P:regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25609812"}]},{"database":"GO","id":"GO:0032880","properties":[{"key":"GoTerm","value":"P:regulation of protein localization"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0031396","properties":[{"key":"GoTerm","value":"P:regulation of protein ubiquitination"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16809764"}]},{"database":"GO","id":"GO:0043254","properties":[{"key":"GoTerm","value":"P:regulation of protein-containing complex assembly"},{"key":"GoEvidenceType","value":"NAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20176123"}]},{"database":"GO","id":"GO:0046677","properties":[{"key":"GoTerm","value":"P:response to antibiotic"},{"key":"GoEvidenceType","value":"ISS:AgBase"}]},{"database":"GO","id":"GO:0061771","properties":[{"key":"GoTerm","value":"P:response to caloric restriction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042220","properties":[{"key":"GoTerm","value":"P:response to cocaine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009409","properties":[{"key":"GoTerm","value":"P:response to cold"},{"key":"GoEvidenceType","value":"ISS:AgBase"}]},{"database":"GO","id":"GO:0002021","properties":[{"key":"GoTerm","value":"P:response to dietary excess"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043627","properties":[{"key":"GoTerm","value":"P:response to estrogen"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032354","properties":[{"key":"GoTerm","value":"P:response to follicle-stimulating hormone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009408","properties":[{"key":"GoTerm","value":"P:response to heat"},{"key":"GoEvidenceType","value":"ISS:AgBase"}]},{"database":"GO","id":"GO:0035900","properties":[{"key":"GoTerm","value":"P:response to isolation stress"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009651","properties":[{"key":"GoTerm","value":"P:response to salt stress"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006986","properties":[{"key":"GoTerm","value":"P:response to unfolded protein"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2527334"}]},{"database":"GO","id":"GO:0009410","properties":[{"key":"GoTerm","value":"P:response to xenobiotic stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003009","properties":[{"key":"GoTerm","value":"P:skeletal muscle contraction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1905323","properties":[{"key":"GoTerm","value":"P:telomerase holoenzyme complex assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10197982"}]},{"database":"GO","id":"GO:0007004","properties":[{"key":"GoTerm","value":"P:telomere maintenance via telomerase"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10197982"}]},{"database":"CDD","id":"cd16927","properties":[{"key":"EntryName","value":"HATPase_Hsp90-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.790:FF:000001","properties":[{"key":"EntryName","value":"Heat shock protein 90 alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.230.80:FF:000001","properties":[{"key":"EntryName","value":"Heat shock protein 90 alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.11260:FF:000001","properties":[{"key":"EntryName","value":"Heat shock protein 90 alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.565.10:FF:000204","properties":[{"key":"EntryName","value":"Heat shock protein HSP 90-beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.230.80","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.11260","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.790","properties":[{"key":"EntryName","value":"Heat shock protein 90, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00505","properties":[{"key":"EntryName","value":"HSP90"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00772","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR003594","properties":[{"key":"EntryName","value":"HATPase_dom"}]},{"database":"InterPro","id":"IPR019805","properties":[{"key":"EntryName","value":"Heat_shock_protein_90_CS"}]},{"database":"InterPro","id":"IPR037196","properties":[{"key":"EntryName","value":"HSP90_C"}]},{"database":"InterPro","id":"IPR001404","properties":[{"key":"EntryName","value":"Hsp90_fam"}]},{"database":"InterPro","id":"IPR020575","properties":[{"key":"EntryName","value":"Hsp90_N"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"NCBIfam","id":"NF003555","properties":[{"key":"EntryName","value":"htpG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11528","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 90 FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13589","properties":[{"key":"EntryName","value":"HATPase_c_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00183","properties":[{"key":"EntryName","value":"HSP90"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF002583","properties":[{"key":"EntryName","value":"Hsp90"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00775","properties":[{"key":"EntryName","value":"HEATSHOCK90"}]},{"database":"SMART","id":"SM00387","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110942","properties":[{"key":"EntryName","value":"HSP90 C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00298","properties":[{"key":"EntryName","value":"HSP90"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD","length":732,"molWeight":84660,"crc64":"969F65FCC0BC86FD","md5":"E80FDEF4A43A3FEA6A16DDA3C56D33FE"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBUNIT":3,"INTERACTION":61,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"DOMAIN":1,"PTM":3,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Region":10,"Motif":1,"Compositional bias":2,"Binding site":5,"Modified residue":17,"Alternative sequence":1,"Mutagenesis":11,"Sequence conflict":4,"Helix":36,"Beta strand":28,"Turn":8,"Natural variant":1},"uniParcId":"UPI0000163B5F"}}