{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P07550","secondaryAccessions":["B0LPE4","B2R7X2","O14823","O14824","O14825","O14826","Q4JG18","Q53GA6","Q6GMT4","Q6P4D8","Q8NEQ9","Q96EC3","Q9UCZ0","Q9UCZ1","Q9UCZ2","Q9UCZ3","Q9UH95","Q9UHA1","Q9UMZ5"],"uniProtkbId":"ADRB2_HUMAN","entryAudit":{"firstPublicDate":"1988-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-05-18","entryVersion":260,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3034889"}],"value":"Beta-2 adrenergic receptor"}},"alternativeNames":[{"fullName":{"value":"Beta-2 adrenoreceptor"},"shortNames":[{"value":"Beta-2 adrenoceptor"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:286"}],"value":"ADRB2"},"synonyms":[{"value":"ADRB2R"},{"value":"B2AR"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P18762"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2831218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33093660"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915137"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9560162"}],"value":"G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways (PubMed:2831218, PubMed:7915137). ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE) (PubMed:2831218, PubMed:33093660, PubMed:7915137). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively (By similarity). Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate (By similarity). Epi also promotes ADRB2 coupling to G(i) proteins to exert cardioprotective effects especially in the conditions of hypoxia and oxidative stress through the G(i)/PI3K/Akt signaling pathway (By similarity). ADRB2-G(s) signaling delivers proapoptotic signals in cardiomyocytes although G(i)-mediated survival effect appears to predominate (By similarity). ADRB2 also transduces signals independently of PKA to regulate cellular pH by modulating Na(+)/H(+) exchanger SLC9A3 function (PubMed:9560162)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10499588"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12142540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17952055"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17962520"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18547522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19424180"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19584355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20559325"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20733053"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21602791"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23166351"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24405750"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25220262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7822302"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9388255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9560162"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9924018"}],"value":"Binds NHERF1 and GPRASP1 (PubMed:9560162). Interacts with ARRB1 and ARRB2. Interacts with SRC (PubMed:9924018). Interacts with USP20 and USP33 (PubMed:19424180, PubMed:23166351). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262). Interacts with NEDD4 (PubMed:23166351). Interacts with MARCHF2 (PubMed:23166351)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"P30542","geneName":"ADORA1","intActId":"EBI-2903663"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"P07550","geneName":"ADRB2","intActId":"EBI-491169"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"P32121","geneName":"ARRB2","intActId":"EBI-714559"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q96B67","geneName":"ARRDC3","intActId":"EBI-2875665"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q9UII2","geneName":"ATP5IF1","intActId":"EBI-718459"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q9ULD4-2","geneName":"BRPF3","intActId":"EBI-23662416"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q9NSI6-4","geneName":"BRWD1","intActId":"EBI-10693038"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q5M9N0-2","geneName":"CCDC158","intActId":"EBI-21796846"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q15700","geneName":"DLG2","intActId":"EBI-80426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"A0AVK6","geneName":"E2F8","intActId":"EBI-7779316"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q658K8","geneName":"EEF1DP3","intActId":"EBI-10248874"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"O00472","geneName":"ELL2","intActId":"EBI-395274"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q15910-2","geneName":"EZH2","intActId":"EBI-10699473"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q15486","geneName":"GUSBP1","intActId":"EBI-712457"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"P61978","geneName":"HNRNPK","intActId":"EBI-304185"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q96QZ7","geneName":"MAGI1","intActId":"EBI-924464"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q5TCQ9","geneName":"MAGI3","intActId":"EBI-310506"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q99685","geneName":"MGLL","intActId":"EBI-721306"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"O14745","geneName":"NHERF1","intActId":"EBI-349787"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q9NR21-5","geneName":"PARP11","intActId":"EBI-17159452"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"O60894","geneName":"RAMP1","intActId":"EBI-962893"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"O60896","geneName":"RAMP3","intActId":"EBI-720447"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q8WVD3","geneName":"RNF138","intActId":"EBI-749039"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q9H0X6","geneName":"RNF208","intActId":"EBI-751555"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q14160","geneName":"SCRIB","intActId":"EBI-357345"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q13573","geneName":"SNW1","intActId":"EBI-632715"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"P12931","geneName":"SRC","intActId":"EBI-621482"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q5T0J7-2","geneName":"TEX35","intActId":"EBI-12833746"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q07157","geneName":"TJP1","intActId":"EBI-79553"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q8N0U2","geneName":"TMEM61","intActId":"EBI-25830583"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P07550","intActId":"EBI-491169"},"interactantTwo":{"uniProtKBAccession":"Q9P202","geneName":"WHRN","intActId":"EBI-310886"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19584355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20559325"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27481942"}],"value":"Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19584355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20559325"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23166351"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25220262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2831218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915137"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19584355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27481942"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11146000"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17962520"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18547522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2540197"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27481942"}],"value":"Palmitoylated (PubMed:11146000, PubMed:17962520, PubMed:18547522, PubMed:2540197, PubMed:27481942). Mainly palmitoylated at Cys-341 (PubMed:17962520, PubMed:18547522, PubMed:2540197). Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (PubMed:11146000). Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi (PubMed:27481942). Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor (PubMed:27481942). Could be depalmitoylated by LYPLA1 at the plasma membrane (PubMed:27481942)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P18762"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11146000"}],"value":"Phosphorylated by PKA and BARK/GRK2 upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK/GRK2 (PubMed:11146000). Distinct temporal phosphorylation on Ser-355 and Ser-356 by BARK/GRK2 plays a critical role for dictating receptor cellular events and signaling properties induced by Epi or NE in cardiomyocytes (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8521811"}],"value":"Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19424180"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20559325"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23166351"}],"value":"Polyubiquitinated (PubMed:23166351). Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation (PubMed:19424180, PubMed:20559325, PubMed:23166351). Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19424180"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19584355"}],"value":"Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2"}],"commentType":"PTM"},{"texts":[{"value":"The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to controls, and appears to be an important genetic factor in the expression of this asthmatic phenotype"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAD96745.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Beta-2 adrenergic receptor","featureId":"PRO_0000069130"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"}]},{"type":"Topological domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"}]},{"type":"Topological domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"}]},{"type":"Topological domain","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"}]},{"type":"Topological domain","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"}]},{"type":"Topological domain","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"}]},{"type":"Topological domain","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"}]},{"type":"Topological domain","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"PDZ-binding"},{"type":"Compositional bias","location":{"start":{"value":393,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:71406"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDO"}],"ligand":{"name":"(R)-adrenaline","id":"ChEBI:CHEBI:71406"}},{"type":"Binding site","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:188146"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17952055"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17962520"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2RH1"}],"ligand":{"name":"(S)-carazolol","id":"ChEBI:CHEBI:188146","note":"inverse agonist"}},{"type":"Binding site","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:188157"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18547522"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3D4S"}],"ligand":{"name":"(S)-timolol","id":"ChEBI:CHEBI:188157","note":"inverse agonist"}},{"type":"Binding site","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:188157"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18547522"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3D4S"}],"ligand":{"name":"(S)-timolol","id":"ChEBI:CHEBI:188157","note":"inverse agonist"}},{"type":"Binding site","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:188146"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17952055"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17962520"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2RH1"}],"ligand":{"name":"(S)-carazolol","id":"ChEBI:CHEBI:188146","note":"inverse agonist"}},{"type":"Binding site","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:71406"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDO"}],"ligand":{"name":"(R)-adrenaline","id":"ChEBI:CHEBI:71406"}},{"type":"Binding site","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:188157"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18547522"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3D4S"}],"ligand":{"name":"(S)-timolol","id":"ChEBI:CHEBI:188157","note":"inverse agonist"}},{"type":"Binding site","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:71406"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDO"}],"ligand":{"name":"(R)-adrenaline","id":"ChEBI:CHEBI:71406"}},{"type":"Binding site","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:188146"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17952055"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17962520"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2RH1"}],"ligand":{"name":"(S)-carazolol","id":"ChEBI:CHEBI:188146","note":"inverse agonist"}},{"type":"Binding site","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:188157"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18547522"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3D4S"}],"ligand":{"name":"(S)-timolol","id":"ChEBI:CHEBI:188157","note":"inverse agonist"}},{"type":"Binding site","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:71406"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDO"}],"ligand":{"name":"(R)-adrenaline","id":"ChEBI:CHEBI:71406"}},{"type":"Binding site","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:188157"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18547522"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3D4S"}],"ligand":{"name":"(S)-timolol","id":"ChEBI:CHEBI:188157","note":"inverse agonist"}},{"type":"Modified residue","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8521811"}]},{"type":"Modified residue","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17525332"}]},{"type":"Modified residue","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11146000"}]},{"type":"Modified residue","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11146000"}]},{"type":"Modified residue","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"Phosphoserine; by BARK","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18056263"}]},{"type":"Modified residue","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Phosphoserine; by BARK","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18056263"}]},{"type":"Modified residue","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"4-hydroxyproline","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19584355"}]},{"type":"Modified residue","location":{"start":{"value":395,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"4-hydroxyproline","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19584355"}]},{"type":"Lipidation","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27481942"}]},{"type":"Lipidation","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17962520"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18547522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2540197"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27481942"}]},{"type":"Glycosylation","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDO"}]},{"type":"Disulfide bond","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24056936"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDO"}]},{"type":"Natural variant","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"in dbSNP:rs33973603","featureCrossReferences":[{"database":"dbSNP","id":"rs33973603"}],"featureId":"VAR_049373","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"in dbSNP:rs1042713","featureCrossReferences":[{"database":"dbSNP","id":"rs1042713"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3025863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3033609"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3034889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7706471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915137"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8383511"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"}],"featureId":"VAR_003452","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"in dbSNP:rs1042714","featureCrossReferences":[{"database":"dbSNP","id":"rs1042714"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11246467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2823249"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3025863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3026848"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3033609"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3034889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915137"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8383511"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.11"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"}],"featureId":"VAR_003453","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"in dbSNP:rs990810566","featureCrossReferences":[{"database":"dbSNP","id":"rs990810566"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8383511"}],"featureId":"VAR_003454","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11246467"}],"featureId":"VAR_009125","alternativeSequence":{"originalSequence":"I","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11246467"}],"featureId":"VAR_009124","alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"in dbSNP:rs1800888","featureCrossReferences":[{"database":"dbSNP","id":"rs1800888"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8383511"}],"featureId":"VAR_003455","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"in dbSNP:rs3729943","featureCrossReferences":[{"database":"dbSNP","id":"rs3729943"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.11"}],"featureId":"VAR_025101","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"in dbSNP:rs771585355","featureCrossReferences":[{"database":"dbSNP","id":"rs771585355"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11246467"}],"featureId":"VAR_009394","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Affects binding of catecholamines, and produces an uncoupling between the receptor and stimulatory G proteins.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2831218"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Abolishes insulin-induced tyrosine phosphorylation and insulin-induced receptor supersensitization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8521811"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Increased noradrenaline affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33093660"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["W"]}},{"type":"Mutagenesis","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Loss of ligand-induced palmitoylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27481942"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Increased noradrenaline affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33093660"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Loss of basal palmitoylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27481942"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Uncoupled receptor.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2540197"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Delayed agonist-promoted desensitization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11146000"}],"alternativeSequence":{"originalSequence":"SS","alternativeSequences":["AA"]}},{"type":"Mutagenesis","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8521811"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8521811"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8521811"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Loss of interaction with NHERF1 after isoprenaline stimulation. Inhibition of SLC9A3 activity after isoprenaline stimulation. No change in adenylyl cyclase activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9560162"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"in Ref. 9; BAG35969","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"in Ref. 8; AAN01267","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"in Ref. 10; BAD96745","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"in Ref. 14; AAH12481","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Beta strand","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3P0G"}]},{"type":"Helix","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Beta strand","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Beta strand","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6PS2"}]},{"type":"Helix","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Turn","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Beta strand","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BUY"}]},{"type":"Helix","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Turn","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8GG0"}]},{"type":"Helix","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Beta strand","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6PS4"}]},{"type":"Helix","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RH1"}]},{"type":"Helix","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8GG3"}]},{"type":"Beta strand","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GQ4"}]},{"type":"Turn","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2R4R"}]},{"type":"Beta strand","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GQ4"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0379","category":"PTM","name":"Hydroxylation"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"3026848","citationType":"journal article","authors":["Chung F.-Z.","Lentes K.-U.","Gocayne J.D.","Fitzgerald M.G.","Robinson D.A.","Kerlavage A.R.","Fraser C.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"3026848"},{"database":"DOI","id":"10.1016/0014-5793(87)81436-9"}],"title":"Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors.","publicationDate":"1987","journal":"FEBS Lett.","firstPage":"200","lastPage":"206","volume":"211"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","VARIANT GLN-27"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"3034889","citationType":"journal article","authors":["Kobilka B.K.","Frielle T.","Dohlman H.G.","Bolanowski M.A.","Dixon R.A.F.","Keller P.","Caron M.G.","Lefkowitz R.J."],"citationCrossReferences":[{"database":"PubMed","id":"3034889"},{"database":"DOI","id":"10.1016/s0021-9258(18)48239-7"}],"title":"Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.","publicationDate":"1987","journal":"J. Biol. Chem.","firstPage":"7321","lastPage":"7327","volume":"262"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS ARG-16 AND GLN-27"]},{"referenceNumber":3,"citation":{"id":"3033609","citationType":"journal article","authors":["Schofield P.R.","Rhee L.M.","Peralta E.G."],"citationCrossReferences":[{"database":"PubMed","id":"3033609"},{"database":"DOI","id":"10.1093/nar/15.8.3636"}],"title":"Primary structure of the human beta-adrenergic receptor gene.","publicationDate":"1987","journal":"Nucleic Acids Res.","firstPage":"3636","lastPage":"3636","volume":"15"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS ARG-16 AND GLN-27"]},{"referenceNumber":4,"citation":{"id":"3025863","citationType":"journal article","authors":["Kobilka B.K.","Dixon R.A.F.","Frielle T.","Dohlman H.G.","Bolanowski M.A.","Sigal I.S.","Yang-Feng T.L.","Francke U.","Caron M.G.","Lefkowitz R.J."],"citationCrossReferences":[{"database":"PubMed","id":"3025863"},{"database":"DOI","id":"10.1073/pnas.84.1.46"}],"title":"cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.","publicationDate":"1987","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"46","lastPage":"50","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","VARIANTS ARG-16 AND GLN-27"]},{"referenceNumber":5,"citation":{"id":"2823249","citationType":"journal article","authors":["Emorine L.J.","Marullo S.","Delavier-Klutchko C.","Kaveri S.V.","Durieu-Trautmann O.","Strosberg A.D."],"citationCrossReferences":[{"database":"PubMed","id":"2823249"},{"database":"DOI","id":"10.1073/pnas.84.20.6995"}],"title":"Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.","publicationDate":"1987","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6995","lastPage":"6999","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT GLN-27"]},{"referenceNumber":6,"citation":{"id":"8383511","citationType":"journal article","authors":["Reihsaus E.","Innis M.","Macintyre N.","Liggett S.B."],"citationCrossReferences":[{"database":"PubMed","id":"8383511"},{"database":"DOI","id":"10.1165/ajrcmb/8.3.334"}],"title":"Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.","publicationDate":"1993","journal":"Am. J. Respir. Cell Mol. Biol.","firstPage":"334","lastPage":"339","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS ARG-16; GLN-27; MET-34 AND ILE-164"]},{"referenceNumber":7,"citation":{"id":"11246467","citationType":"journal article","authors":["Rupert J.L.","Monsalve M.V.","Devine D.V.","Hochachka P.W."],"citationCrossReferences":[{"database":"PubMed","id":"11246467"},{"database":"DOI","id":"10.1017/s0003480000008009"}],"title":"Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population.","publicationDate":"2000","journal":"Ann. Hum. Genet.","firstPage":"135","lastPage":"143","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS GLN-27; LEU-159; PHE-159 AND ARG-375"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"CI-A6VD5CI1Q2HUA","citationType":"submission","authors":["Puhl H.L. III","Ikeda S.R.","Aronstam R.S."],"title":"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).","publicationDate":"JUL-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANTS ARG-16 AND GLN-27"],"referenceComments":[{"value":"Heart","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"CI-5AVBODINQ93DF","citationType":"submission","authors":["Suzuki Y.","Sugano S.","Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S."],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT GLN-27"],"referenceComments":[{"value":"Thyroid","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"CI-DG517G2GQIOQ6","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"JUN-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS GLN-27 AND CYS-220"]},{"referenceNumber":12,"citation":{"id":"CI-FDNV2K4FQT0J2","citationType":"submission","authoringGroup":["NHLBI resequencing and genotyping service (RS&G)"],"publicationDate":"DEC-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT GLN-27"]},{"referenceNumber":13,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":14,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANTS ARG-16 AND GLN-27"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"},{"value":"Leukocyte","type":"TISSUE"},{"value":"Prostate","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"2831218","citationType":"journal article","authors":["Chung F.-Z.","Wang C.-D.","Potter P.C.","Venter J.C.","Fraser C.M."],"citationCrossReferences":[{"database":"PubMed","id":"2831218"},{"database":"DOI","id":"10.1016/s0021-9258(18)68888-x"}],"title":"Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation.","publicationDate":"1988","journal":"J. Biol. Chem.","firstPage":"4052","lastPage":"4055","volume":"263"},"referencePositions":["MUTAGENESIS OF ASP-79","FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":16,"citation":{"id":"2540197","citationType":"journal article","authors":["O'Dowd B.F.","Hnatowich M.","Caron M.G.","Lefkowitz R.J.","Bouvier M."],"citationCrossReferences":[{"database":"PubMed","id":"2540197"},{"database":"DOI","id":"10.1016/s0021-9258(18)83271-9"}],"title":"Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"7564","lastPage":"7569","volume":"264"},"referencePositions":["PALMITOYLATION AT CYS-341","MUTAGENESIS OF CYS-341"]},{"referenceNumber":17,"citation":{"id":"8521811","citationType":"journal article","authors":["Valiquette M.","Parent S.","Loisel T.P.","Bouvier M."],"citationCrossReferences":[{"database":"PubMed","id":"8521811"},{"database":"DOI","id":"10.1002/j.1460-2075.1995.tb00241.x"}],"title":"Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.","publicationDate":"1995","journal":"EMBO J.","firstPage":"5542","lastPage":"5549","volume":"14"},"referencePositions":["MUTAGENESIS OF TYR-141; TYR-350; TYR-354 AND TYR-366","PHOSPHORYLATION AT TYR-141"]},{"referenceNumber":18,"citation":{"id":"7822302","citationType":"journal article","authors":["Gurevich V.V.","Dion S.B.","Onorato J.J.","Ptasienski J.","Kim C.M.","Sterne-Marr R.","Hosey M.M.","Benovic J.L."],"citationCrossReferences":[{"database":"PubMed","id":"7822302"},{"database":"DOI","id":"10.1074/jbc.270.2.720"}],"title":"Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"720","lastPage":"731","volume":"270"},"referencePositions":["INTERACTION WITH ARRB1 AND ARRB2"]},{"referenceNumber":19,"citation":{"id":"9388255","citationType":"journal article","authors":["Lin F.-T.","Krueger K.M.","Kendall H.E.","Daaka Y.","Fredericks Z.L.","Pitcher J.A.","Lefkowitz R.J."],"citationCrossReferences":[{"database":"PubMed","id":"9388255"},{"database":"DOI","id":"10.1074/jbc.272.49.31051"}],"title":"Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"31051","lastPage":"31057","volume":"272"},"referencePositions":["INTERACTION WITH ARRB1"]},{"referenceNumber":20,"citation":{"id":"9560162","citationType":"journal article","authors":["Hall R.A.","Premont R.T.","Chow C.-W.","Blitzer J.T.","Pitcher J.A.","Claing A.","Stoffel R.H.","Barak L.S.","Shenolikar S.","Weinman E.J.","Grinstein S.","Lefkowitz R.J."],"citationCrossReferences":[{"database":"PubMed","id":"9560162"},{"database":"DOI","id":"10.1038/33458"}],"title":"The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.","publicationDate":"1998","journal":"Nature","firstPage":"626","lastPage":"630","volume":"392"},"referencePositions":["FUNCTION","INTERACTION WITH NHERF1","MUTAGENESIS OF LEU-413"]},{"referenceNumber":21,"citation":{"id":"10499588","citationType":"journal article","authors":["Cao T.T.","Deacon H.W.","Reczek D.","Bretscher A.","von Zastrow M."],"citationCrossReferences":[{"database":"PubMed","id":"10499588"},{"database":"DOI","id":"10.1038/45816"}],"title":"A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.","publicationDate":"1999","journal":"Nature","firstPage":"286","lastPage":"290","volume":"401"},"referencePositions":["INTERACTION WITH NHERF1"]},{"referenceNumber":22,"citation":{"id":"9924018","citationType":"journal article","authors":["Luttrell L.M.","Ferguson S.S.G.","Daaka Y.","Miller W.E.","Maudsley S.","Della Rocca G.J.","Lin F.-T.","Kawakatsu H.","Owada K.","Luttrell D.K.","Caron M.G.","Lefkowitz R.J."],"citationCrossReferences":[{"database":"PubMed","id":"9924018"},{"database":"DOI","id":"10.1126/science.283.5402.655"}],"title":"Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.","publicationDate":"1999","journal":"Science","firstPage":"655","lastPage":"661","volume":"283"},"referencePositions":["INTERACTION WITH SRC AND ARRB1"]},{"referenceNumber":23,"citation":{"id":"11146000","citationType":"journal article","authors":["Moffett S.","Rousseau G.","Lagace M.","Bouvier M."],"citationCrossReferences":[{"database":"PubMed","id":"11146000"},{"database":"DOI","id":"10.1046/j.1471-4159.2001.00005.x"}],"title":"The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization.","publicationDate":"2001","journal":"J. Neurochem.","firstPage":"269","lastPage":"279","volume":"76"},"referencePositions":["EFFECT OF PALMITOYLATION","PHOSPHORYLATION AT SER-345 AND SER-346","MUTAGENESIS OF 345-SER-SER-346"]},{"referenceNumber":24,"citation":{"id":"18056263","citationType":"journal article","authors":["Wang Y.","De Arcangelis V.","Gao X.","Ramani B.","Jung Y.S.","Xiang Y."],"citationCrossReferences":[{"database":"PubMed","id":"18056263"},{"database":"DOI","id":"10.1074/jbc.m705747200"}],"title":"Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"1799","lastPage":"1807","volume":"283"},"referencePositions":["PHOSPHORYLATION AT SER-355 AND SER-356"]},{"referenceNumber":25,"citation":{"id":"12142540","citationType":"journal article","authors":["Whistler J.L.","Enquist J.","Marley A.","Fong J.","Gladher F.","Tsuruda P.","Murray S.R.","Von Zastrow M."],"citationCrossReferences":[{"database":"PubMed","id":"12142540"},{"database":"DOI","id":"10.1126/science.1073308"}],"title":"Modulation of postendocytic sorting of G protein-coupled receptors.","publicationDate":"2002","journal":"Science","firstPage":"615","lastPage":"620","volume":"297"},"referencePositions":["INTERACTION WITH GPRASP1"]},{"referenceNumber":26,"citation":{"id":"17525332","citationType":"journal article","authors":["Matsuoka S.","Ballif B.A.","Smogorzewska A.","McDonald E.R. III","Hurov K.E.","Luo J.","Bakalarski C.E.","Zhao Z.","Solimini N.","Lerenthal Y.","Shiloh Y.","Gygi S.P.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17525332"},{"database":"DOI","id":"10.1126/science.1140321"}],"title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.","publicationDate":"2007","journal":"Science","firstPage":"1160","lastPage":"1166","volume":"316"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic kidney","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"19424180","citationType":"journal article","authors":["Berthouze M.","Venkataramanan V.","Li Y.","Shenoy S.K."],"citationCrossReferences":[{"database":"PubMed","id":"19424180"},{"database":"DOI","id":"10.1038/emboj.2009.128"}],"title":"The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.","publicationDate":"2009","journal":"EMBO J.","firstPage":"1684","lastPage":"1696","volume":"28"},"referencePositions":["UBIQUITINATION","DEUBIQUITINATION BY USP20 AND USP33","INTERACTION WITH USP20 AND USP33"]},{"referenceNumber":28,"citation":{"id":"19584355","citationType":"journal article","authors":["Xie L.","Xiao K.","Whalen E.J.","Forrester M.T.","Freeman R.S.","Fong G.","Gygi S.P.","Lefkowitz R.J.","Stamler J.S."],"citationCrossReferences":[{"database":"PubMed","id":"19584355"},{"database":"DOI","id":"10.1126/scisignal.2000444"}],"title":"Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA33","lastPage":"RA33","volume":"2"},"referencePositions":["INTERACTION WITH EGLN3 AND VHL","SUBCELLULAR LOCATION","INDUCTION","UBIQUITINATION","HYDROXYLATION AT PRO-382 AND PRO-395","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":29,"citation":{"id":"20559325","citationType":"journal article","authors":["Nabhan J.F.","Pan H.","Lu Q."],"citationCrossReferences":[{"database":"PubMed","id":"20559325"},{"database":"DOI","id":"10.1038/embor.2010.80"}],"title":"Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.","publicationDate":"2010","journal":"EMBO Rep.","firstPage":"605","lastPage":"611","volume":"11"},"referencePositions":["UBIQUITINATION","SUBCELLULAR LOCATION","INTERACTION WITH ARRDC3"]},{"referenceNumber":30,"citation":{"id":"20733053","citationType":"journal article","authors":["Lauffer B.E.","Melero C.","Temkin P.","Lei C.","Hong W.","Kortemme T.","von Zastrow M."],"citationCrossReferences":[{"database":"PubMed","id":"20733053"},{"database":"DOI","id":"10.1083/jcb.201004060"}],"title":"SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane.","publicationDate":"2010","journal":"J. Cell Biol.","firstPage":"565","lastPage":"574","volume":"190"},"referencePositions":["INTERACTION WITH SNX27"]},{"referenceNumber":31,"citation":{"id":"21602791","citationType":"journal article","authors":["Temkin P.","Lauffer B.","Jager S.","Cimermancic P.","Krogan N.J.","von Zastrow M."],"citationCrossReferences":[{"database":"PubMed","id":"21602791"},{"database":"DOI","id":"10.1038/ncb2252"}],"title":"SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.","publicationDate":"2011","journal":"Nat. Cell Biol.","firstPage":"715","lastPage":"721","volume":"13"},"referencePositions":["INTERACTION WITH SNX27"]},{"referenceNumber":32,"citation":{"id":"23166351","citationType":"journal article","authors":["Han S.O.","Xiao K.","Kim J.","Wu J.H.","Wisler J.W.","Nakamura N.","Freedman N.J.","Shenoy S.K."],"citationCrossReferences":[{"database":"PubMed","id":"23166351"},{"database":"DOI","id":"10.1083/jcb.201208192"}],"title":"MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors.","publicationDate":"2012","journal":"J. Cell Biol.","firstPage":"817","lastPage":"830","volume":"199"},"referencePositions":["INTERACTION WITH MARCHF2; NEDD4; USP20 AND USP33","SUBCELLULAR LOCATION","UBIQUITINATION"]},{"referenceNumber":33,"citation":{"id":"25220262","citationType":"journal article","authors":["Qi S.","O'Hayre M.","Gutkind J.S.","Hurley J.H."],"citationCrossReferences":[{"database":"PubMed","id":"25220262"},{"database":"DOI","id":"10.1002/pro.2549"}],"title":"Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.","publicationDate":"2014","journal":"Protein Sci.","firstPage":"1708","lastPage":"1716","volume":"23"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH ARRDC3"]},{"referenceNumber":34,"citation":{"id":"24405750","citationType":"journal article","authors":["Sauvageau E.","Rochdi M.D.","Oueslati M.","Hamdan F.F.","Percherancier Y.","Simpson J.C.","Pepperkok R.","Bouvier M."],"citationCrossReferences":[{"database":"PubMed","id":"24405750"},{"database":"DOI","id":"10.1111/tra.12148"}],"title":"CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.","publicationDate":"2014","journal":"Traffic","firstPage":"383","lastPage":"400","volume":"15"},"referencePositions":["INTERACTION WITH CNIH4"]},{"referenceNumber":35,"citation":{"id":"27481942","citationType":"journal article","authors":["Adachi N.","Hess D.T.","McLaughlin P.","Stamler J.S."],"citationCrossReferences":[{"database":"PubMed","id":"27481942"},{"database":"DOI","id":"10.1074/jbc.m116.725762"}],"title":"S-Palmitoylation of a Novel Site in the beta2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary.","publicationDate":"2016","journal":"J. Biol. Chem.","firstPage":"20232","lastPage":"20246","volume":"291"},"referencePositions":["SUBCELLULAR LOCATION","PALMITOYLATION AT CYS-265 AND CYS-341","MUTAGENESIS OF CYS-265 AND CYS-341"]},{"referenceNumber":36,"citation":{"id":"33093660","citationType":"journal article","authors":["Xu X.","Kaindl J.","Clark M.J.","Hubner H.","Hirata K.","Sunahara R.K.","Gmeiner P.","Kobilka B.K.","Liu X."],"citationCrossReferences":[{"database":"PubMed","id":"33093660"},{"database":"DOI","id":"10.1038/s41422-020-00424-2"}],"title":"Binding pathway determines norepinephrine selectivity for the human beta1AR over beta2AR.","publicationDate":"2021","journal":"Cell Res.","firstPage":"569","lastPage":"579","volume":"31"},"referencePositions":["FUNCTION","MUTAGENESIS OF TYR-174 AND ASP-300"]},{"referenceNumber":37,"citation":{"id":"17952055","citationType":"journal article","authors":["Rasmussen S.G.F.","Choi H.-J.","Rosenbaum D.M.","Kobilka T.S.","Thian F.S.","Edwards P.C.","Burghammer M.","Ratnala V.R.P.","Sanishvili R.","Fischetti R.F.","Schertler G.F.X.","Weis W.I.","Kobilka B.K."],"citationCrossReferences":[{"database":"PubMed","id":"17952055"},{"database":"DOI","id":"10.1038/nature06325"}],"title":"Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.","publicationDate":"2007","journal":"Nature","firstPage":"383","lastPage":"387","volume":"450"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 1-365 IN COMPLEX WITH CARAZOLOL","TOPOLOGY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2R4R"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2R4S"}]},{"referenceNumber":38,"citation":{"id":"17962520","citationType":"journal article","authors":["Cherezov V.","Rosenbaum D.M.","Hanson M.A.","Rasmussen S.G.F.","Thian F.S.","Kobilka T.S.","Choi H.-J.","Kuhn P.","Weis W.I.","Kobilka B.K.","Stevens R.C."],"citationCrossReferences":[{"database":"PubMed","id":"17962520"},{"database":"DOI","id":"10.1126/science.1150577"}],"title":"High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.","publicationDate":"2007","journal":"Science","firstPage":"1258","lastPage":"1265","volume":"318"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-365 IN COMPLEX WITH CARAZOLOL AND CHOLESTEROL","DISULFIDE BONDS","TOPOLOGY","PALMITOYLATION AT CYS-341"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2RH1"}]},{"referenceNumber":39,"citation":{"id":"18547522","citationType":"journal article","authors":["Hanson M.A.","Cherezov V.","Griffith M.T.","Roth C.B.","Jaakola V.P.","Chien E.Y.","Velasquez J.","Kuhn P.","Stevens R.C."],"citationCrossReferences":[{"database":"PubMed","id":"18547522"},{"database":"DOI","id":"10.1016/j.str.2008.05.001"}],"title":"A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.","publicationDate":"2008","journal":"Structure","firstPage":"897","lastPage":"905","volume":"16"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-365 IN COMPLEX WITH TIMOLOL AND CHOLESTEROL","DISULFIDE BONDS","TOPOLOGY","PALMITOYLATION AT CYS-341"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3D4S"}]},{"referenceNumber":40,"citation":{"id":"24056936","citationType":"journal article","authors":["Ring A.M.","Manglik A.","Kruse A.C.","Enos M.D.","Weis W.I.","Garcia K.C.","Kobilka B.K."],"citationCrossReferences":[{"database":"PubMed","id":"24056936"},{"database":"DOI","id":"10.1038/nature12572"}],"title":"Adrenaline-activated structure of beta2-adrenoceptor stabilized by an engineered nanobody.","publicationDate":"2013","journal":"Nature","firstPage":"575","lastPage":"579","volume":"502"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.79 ANGSTROMS) OF 29-348 IN COMPLEX WITH (R)-ADRENALINE AND G PROTEINS","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDE"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4LDO"}]},{"referenceNumber":41,"citation":{"id":"7915137","citationType":"journal article","authors":["Green S.A.","Turki J.","Innis M.","Ligget S.B."],"citationCrossReferences":[{"database":"PubMed","id":"7915137"},{"database":"DOI","id":"10.1021/bi00198a006"}],"title":"Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.","publicationDate":"1994","journal":"Biochemistry","firstPage":"9414","lastPage":"9419","volume":"33"},"referencePositions":["VARIANTS ARG-16 AND GLN-27","CHARACTERIZATION","FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":42,"citation":{"id":"7706471","citationType":"journal article","authors":["Turki J.","Pak J.","Green S.A.","Martin R.J.","Liggett S.B."],"citationCrossReferences":[{"database":"PubMed","id":"7706471"},{"database":"DOI","id":"10.1172/jci117838"}],"title":"Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.","publicationDate":"1995","journal":"J. Clin. Invest.","firstPage":"1635","lastPage":"1641","volume":"95"},"referencePositions":["VARIANT ARG-16","POLYMORPHISM"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X04827","properties":[{"key":"ProteinId","value":"CAA28511.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Y00106","properties":[{"key":"ProteinId","value":"CAA68289.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M15169","properties":[{"key":"ProteinId","value":"AAA88015.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"J02960","properties":[{"key":"ProteinId","value":"AAA88017.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF022953","properties":[{"key":"ProteinId","value":"AAB82148.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF022954","properties":[{"key":"ProteinId","value":"AAB82149.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF022955","properties":[{"key":"ProteinId","value":"AAB82150.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF022956","properties":[{"key":"ProteinId","value":"AAB82151.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF169225","properties":[{"key":"ProteinId","value":"AAD48036.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF202305","properties":[{"key":"ProteinId","value":"AAF17569.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF203386","properties":[{"key":"ProteinId","value":"AAF20199.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY136741","properties":[{"key":"ProteinId","value":"AAN01267.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK313151","properties":[{"key":"ProteinId","value":"BAG35969.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK223025","properties":[{"key":"ProteinId","value":"BAD96745.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ094845","properties":[{"key":"ProteinId","value":"AAY88739.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EU332834","properties":[{"key":"ProteinId","value":"ABY87523.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471062","properties":[{"key":"ProteinId","value":"EAW61798.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC012481","properties":[{"key":"ProteinId","value":"AAH12481.3"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC063486","properties":[{"key":"ProteinId","value":"AAH63486.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC073856","properties":[{"key":"ProteinId","value":"AAH73856.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS4292.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A27525","properties":[{"key":"EntryName","value":"QRHUB2"}]},{"database":"RefSeq","id":"NP_000015.2","properties":[{"key":"NucleotideSequenceId","value":"NM_000024.6"}]},{"database":"PDB","id":"1GQ4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=336-366"}]},{"database":"PDB","id":"2R4R","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A=1-365"}]},{"database":"PDB","id":"2R4S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A=24-365"}]},{"database":"PDB","id":"2RH1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=1-230, A=264-365"}]},{"database":"PDB","id":"3D4S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"3KJ6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A=2-365"}]},{"database":"PDB","id":"3NY8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.84 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"3NY9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.84 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"3NYA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.16 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"3P0G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A=1-230, A=264-365"}]},{"database":"PDB","id":"3PDS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A=25-230, A=264-348"}]},{"database":"PDB","id":"3SN6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"R=29-365"}]},{"database":"PDB","id":"4GBR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.99 A"},{"key":"Chains","value":"A=29-365"}]},{"database":"PDB","id":"4LDE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.79 A"},{"key":"Chains","value":"A=29-348"}]},{"database":"PDB","id":"4LDL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=29-348"}]},{"database":"PDB","id":"4LDO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=29-348"}]},{"database":"PDB","id":"4QKX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A=29-348"}]},{"database":"PDB","id":"5D5A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.48 A"},{"key":"Chains","value":"A=1-230, A=264-365"}]},{"database":"PDB","id":"5D5B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A=1-230, A=264-365"}]},{"database":"PDB","id":"5D6L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-223, A=264-365"}]},{"database":"PDB","id":"5JQH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B=30-348"}]},{"database":"PDB","id":"5X7D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=1-230, A=264-365"}]},{"database":"PDB","id":"6E67","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"A/B=1-232, A/B=268-365"}]},{"database":"PDB","id":"6KR8","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=25-350"}]},{"database":"PDB","id":"6MXT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.96 A"},{"key":"Chains","value":"A=29-365"}]},{"database":"PDB","id":"6N48","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=29-348"}]},{"database":"PDB","id":"6NI3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"R=29-341"}]},{"database":"PDB","id":"6OBA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=1-230, A=264-365"}]},{"database":"PDB","id":"6PRZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"6PS0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"6PS1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"6PS2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"6PS3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"6PS4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"6PS5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"6PS6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=1-230, A=264-348"}]},{"database":"PDB","id":"7BZ2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.82 A"},{"key":"Chains","value":"R=1-348"}]},{"database":"PDB","id":"7DHI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.26 A"},{"key":"Chains","value":"R=1-348"}]},{"database":"PDB","id":"7DHR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"R=1-348"}]},{"database":"PDB","id":"7XK9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A=29-348"}]},{"database":"PDB","id":"7XKA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=29-348"}]},{"database":"PDB","id":"8GDZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GE1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GE2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GE3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GE4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GE5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GE6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GE7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GE8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GE9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GEA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GEB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GEC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GED","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GEE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GEF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GEG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GEH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GEI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.10 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GEJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.20 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GFV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GFW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GFX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GFY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GFZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GG9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GGZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GH0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8GH1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.10 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8JJ8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"F=29-230, F=263-340"}]},{"database":"PDB","id":"8JJL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=29-230, A=263-340"}]},{"database":"PDB","id":"8JJO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"F=29-230, F=262-340"}]},{"database":"PDB","id":"8UHB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.35 A"},{"key":"Chains","value":"A=1-30"}]},{"database":"PDB","id":"8UNL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UNZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UO0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UO1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UO2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UO3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8UO4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"8W1V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B=1-365"}]},{"database":"PDB","id":"8ZBE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.24 A"},{"key":"Chains","value":"A=1-24, A=385-400"}]},{"database":"PDB","id":"8ZCJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.09 A"},{"key":"Chains","value":"G=1-24, G=385-400"}]},{"database":"PDB","id":"8ZWF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A=1-30"}]},{"database":"PDB","id":"8ZWG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.87 A"},{"key":"Chains","value":"A=1-30"}]},{"database":"PDB","id":"9BUY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"9CHU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.49 A"},{"key":"Chains","value":"A=29-230, A=263-336"}]},{"database":"PDB","id":"9CHV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.95 A"},{"key":"Chains","value":"A=29-230, A=263-354"}]},{"database":"PDB","id":"9CHX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A=29-230, A=263-354"}]},{"database":"PDB","id":"9I52","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"R=1-30"}]},{"database":"PDB","id":"9I54","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.72 A"},{"key":"Chains","value":"R=1-30"}]},{"database":"PDB","id":"9L8L","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.22 A"},{"key":"Chains","value":"R=1-413"}]},{"database":"PDB","id":"9LW5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.87 A"},{"key":"Chains","value":"R=1-348"}]},{"database":"PDB","id":"9RKF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A=28-230, A=264-342"}]},{"database":"PDB","id":"9RKG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A=29-230, A=264-342"}]},{"database":"PDB","id":"9RKH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=29-230, A=264-342"}]},{"database":"PDB","id":"9RKI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=29-230, A=264-342"}]},{"database":"PDB","id":"9U4Y","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.67 A"},{"key":"Chains","value":"R=1-30, R=41-326"}]},{"database":"PDB","id":"9U9V","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"R=1-348"}]},{"database":"PDB","id":"9UAM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A=2-30, A=377-400"}]},{"database":"PDBsum","id":"1GQ4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2R4R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2R4S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2RH1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3D4S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3KJ6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NY8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NY9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NYA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3P0G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3PDS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3SN6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4GBR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4LDE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4LDL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4LDO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4QKX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5D5A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5D5B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5D6L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JQH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5X7D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6E67","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KR8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MXT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6N48","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6NI3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6OBA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PRZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PS0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PS1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PS2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PS3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PS4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PS5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PS6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7BZ2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7DHI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7DHR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XK9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XKA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GDZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GE1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GE2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GE3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GE4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GE5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GE6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GE7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GE8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GE9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GEA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GEB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GEC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GED","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GEE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GEF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GEG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GEH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GEI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GEJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GFV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GFW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GFX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GFY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GFZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GG9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GGZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GH0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GH1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JJ8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JJL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JJO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UHB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UNZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UO0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UO1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UO2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UO3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UO4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8W1V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ZBE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ZCJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ZWF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ZWG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BUY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CHU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CHV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CHX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9I52","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9I54","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9L8L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9LW5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9RKF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9RKG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9RKH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9RKI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9U4Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9U9V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9UAM","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29951","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29952","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29953","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29954","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29955","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29956","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29958","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29959","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29960","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29961","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29962","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29964","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29965","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29966","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29967","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29968","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29969","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29970","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29971","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29972","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29985","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29986","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29987","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29988","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29989","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29990","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29991","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29992","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29993","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29994","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29995","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29996","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29997","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29998","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29999","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30249","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30681","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30682","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36342","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36360","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36361","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40000","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40001","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40002","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40004","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40005","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40009","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40010","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40011","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40012","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40013","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40014","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40015","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40016","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40017","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40018","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40019","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40020","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40021","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40022","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40023","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40024","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40025","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40026","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40027","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40028","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40096","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40097","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40098","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40099","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40100","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40101","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40102","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40103","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40104","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40105","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40106","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40107","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40108","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40109","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40110","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40111","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40112","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40113","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40114","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40115","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40116","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40117","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40118","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40119","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40121","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40122","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40123","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40124","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40125","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40126","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40127","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40128","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40129","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40130","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40131","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40132","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40133","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40134","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40135","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40136","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40137","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40138","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40139","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40140","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40141","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40142","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40143","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40144","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40145","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40146","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40147","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40148","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40149","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40150","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40152","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40153","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40154","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40155","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40157","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40158","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40159","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40160","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40161","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40163","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40164","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40165","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40166","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40167","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40170","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40171","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40172","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40173","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40174","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40175","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40176","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42408","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42409","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42410","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42411","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42412","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42413","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42414","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42415","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42416","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42417","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42418","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42419","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42420","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42421","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42422","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42423","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42424","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42425","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42426","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42427","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44925","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45602","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45603","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45604","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62885","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-63431","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-63971","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9376","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"106663","properties":[{"key":"Interactions","value":"327"}]},{"database":"CORUM","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-33948N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P07550","properties":[{"key":"Number of interactors","value":"1168"}]},{"database":"IntAct","id":"P07550","properties":[{"key":"Interactions","value":"179"}]},{"database":"MINT","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-ADRB2","properties":[{"key":"Evidences","value":"14 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000305372","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL210","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB07543","properties":[{"key":"GenericName","value":"(S)-carazolol"}]},{"database":"DrugBank","id":"DB12100","properties":[{"key":"GenericName","value":"Abediterol"}]},{"database":"DrugBank","id":"DB01193","properties":[{"key":"GenericName","value":"Acebutolol"}]},{"database":"DrugBank","id":"DB01001","properties":[{"key":"GenericName","value":"Albuterol"}]},{"database":"DrugBank","id":"DB00866","properties":[{"key":"GenericName","value":"Alprenolol"}]},{"database":"DrugBank","id":"DB01118","properties":[{"key":"GenericName","value":"Amiodarone"}]},{"database":"DrugBank","id":"DB00182","properties":[{"key":"GenericName","value":"Amphetamine"}]},{"database":"DrugBank","id":"DB18759","properties":[{"key":"GenericName","value":"APD-209"}]},{"database":"DrugBank","id":"DB01102","properties":[{"key":"GenericName","value":"Arbutamine"}]},{"database":"DrugBank","id":"DB01274","properties":[{"key":"GenericName","value":"Arformoterol"}]},{"database":"DrugBank","id":"DB01238","properties":[{"key":"GenericName","value":"Aripiprazole"}]},{"database":"DrugBank","id":"DB09204","properties":[{"key":"GenericName","value":"Arotinolol"}]},{"database":"DrugBank","id":"DB06216","properties":[{"key":"GenericName","value":"Asenapine"}]},{"database":"DrugBank","id":"DB00335","properties":[{"key":"GenericName","value":"Atenolol"}]},{"database":"DrugBank","id":"DB01408","properties":[{"key":"GenericName","value":"Bambuterol"}]},{"database":"DrugBank","id":"DB12526","properties":[{"key":"GenericName","value":"Batefenterol"}]},{"database":"DrugBank","id":"DB05590","properties":[{"key":"GenericName","value":"Bedoradrine"}]},{"database":"DrugBank","id":"DB09013","properties":[{"key":"GenericName","value":"Befunolol"}]},{"database":"DrugBank","id":"DB00195","properties":[{"key":"GenericName","value":"Betaxolol"}]},{"database":"DrugBank","id":"DB00217","properties":[{"key":"GenericName","value":"Bethanidine"}]},{"database":"DrugBank","id":"DB01295","properties":[{"key":"GenericName","value":"Bevantolol"}]},{"database":"DrugBank","id":"DB00612","properties":[{"key":"GenericName","value":"Bisoprolol"}]},{"database":"DrugBank","id":"DB00901","properties":[{"key":"GenericName","value":"Bitolterol"}]},{"database":"DrugBank","id":"DB08807","properties":[{"key":"GenericName","value":"Bopindolol"}]},{"database":"DrugBank","id":"DB12752","properties":[{"key":"GenericName","value":"Bucindolol"}]},{"database":"DrugBank","id":"DB06726","properties":[{"key":"GenericName","value":"Bufuralol"}]},{"database":"DrugBank","id":"DB08808","properties":[{"key":"GenericName","value":"Bupranolol"}]},{"database":"DrugBank","id":"DB00248","properties":[{"key":"GenericName","value":"Cabergoline"}]},{"database":"DrugBank","id":"DB15784","properties":[{"key":"GenericName","value":"Carmoterol"}]},{"database":"DrugBank","id":"DB00521","properties":[{"key":"GenericName","value":"Carteolol"}]},{"database":"DrugBank","id":"DB01136","properties":[{"key":"GenericName","value":"Carvedilol"}]},{"database":"DrugBank","id":"DB04846","properties":[{"key":"GenericName","value":"Celiprolol"}]},{"database":"DrugBank","id":"DB01407","properties":[{"key":"GenericName","value":"Clenbuterol"}]},{"database":"DrugBank","id":"DB00785","properties":[{"key":"GenericName","value":"Cryptenamine"}]},{"database":"DrugBank","id":"DB01151","properties":[{"key":"GenericName","value":"Desipramine"}]},{"database":"DrugBank","id":"DB12803","properties":[{"key":"GenericName","value":"Dichloroisoproterenol"}]},{"database":"DrugBank","id":"DB11273","properties":[{"key":"GenericName","value":"Dihydroergocornine"}]},{"database":"DrugBank","id":"DB13345","properties":[{"key":"GenericName","value":"Dihydroergocristine"}]},{"database":"DrugBank","id":"DB00449","properties":[{"key":"GenericName","value":"Dipivefrin"}]},{"database":"DrugBank","id":"DB11278","properties":[{"key":"GenericName","value":"DL-Methylephedrine"}]},{"database":"DrugBank","id":"DB00841","properties":[{"key":"GenericName","value":"Dobutamine"}]},{"database":"DrugBank","id":"DB09273","properties":[{"key":"GenericName","value":"Doxofylline"}]},{"database":"DrugBank","id":"DB06262","properties":[{"key":"GenericName","value":"Droxidopa"}]},{"database":"DrugBank","id":"DB01363","properties":[{"key":"GenericName","value":"Ephedra sinica root"}]},{"database":"DrugBank","id":"DB01364","properties":[{"key":"GenericName","value":"Ephedrine"}]},{"database":"DrugBank","id":"DB00668","properties":[{"key":"GenericName","value":"Epinephrine"}]},{"database":"DrugBank","id":"DB01049","properties":[{"key":"GenericName","value":"Ergoloid mesylate"}]},{"database":"DrugBank","id":"DB11587","properties":[{"key":"GenericName","value":"Etafedrine"}]},{"database":"DrugBank","id":"DB01288","properties":[{"key":"GenericName","value":"Fenoterol"}]},{"database":"DrugBank","id":"DB00983","properties":[{"key":"GenericName","value":"Formoterol"}]},{"database":"DrugBank","id":"DB04946","properties":[{"key":"GenericName","value":"Iloperidone"}]},{"database":"DrugBank","id":"DB05039","properties":[{"key":"GenericName","value":"Indacaterol"}]},{"database":"DrugBank","id":"DB00221","properties":[{"key":"GenericName","value":"Isoetharine"}]},{"database":"DrugBank","id":"DB01064","properties":[{"key":"GenericName","value":"Isoprenaline"}]},{"database":"DrugBank","id":"DB00598","properties":[{"key":"GenericName","value":"Labetalol"}]},{"database":"DrugBank","id":"DB12212","properties":[{"key":"GenericName","value":"Landiolol"}]},{"database":"DrugBank","id":"DB01210","properties":[{"key":"GenericName","value":"Levobunolol"}]},{"database":"DrugBank","id":"DB13139","properties":[{"key":"GenericName","value":"Levosalbutamol"}]},{"database":"DrugBank","id":"DB20693","properties":[{"key":"GenericName","value":"Meluadrine"}]},{"database":"DrugBank","id":"DB01365","properties":[{"key":"GenericName","value":"Mephentermine"}]},{"database":"DrugBank","id":"DB13624","properties":[{"key":"GenericName","value":"Methoxyphenamine"}]},{"database":"DrugBank","id":"DB01214","properties":[{"key":"GenericName","value":"Metipranolol"}]},{"database":"DrugBank","id":"DB00264","properties":[{"key":"GenericName","value":"Metoprolol"}]},{"database":"DrugBank","id":"DB05043","properties":[{"key":"GenericName","value":"Milveterol"}]},{"database":"DrugBank","id":"DB01203","properties":[{"key":"GenericName","value":"Nadolol"}]},{"database":"DrugBank","id":"DB05849","properties":[{"key":"GenericName","value":"NCX 950"}]},{"database":"DrugBank","id":"DB04861","properties":[{"key":"GenericName","value":"Nebivolol"}]},{"database":"DrugBank","id":"DB00368","properties":[{"key":"GenericName","value":"Norepinephrine"}]},{"database":"DrugBank","id":"DB00540","properties":[{"key":"GenericName","value":"Nortriptyline"}]},{"database":"DrugBank","id":"DB00334","properties":[{"key":"GenericName","value":"Olanzapine"}]},{"database":"DrugBank","id":"DB09080","properties":[{"key":"GenericName","value":"Olodaterol"}]},{"database":"DrugBank","id":"DB00816","properties":[{"key":"GenericName","value":"Orciprenaline"}]},{"database":"DrugBank","id":"DB01580","properties":[{"key":"GenericName","value":"Oxprenolol"}]},{"database":"DrugBank","id":"DB00715","properties":[{"key":"GenericName","value":"Paroxetine"}]},{"database":"DrugBank","id":"DB01359","properties":[{"key":"GenericName","value":"Penbutolol"}]},{"database":"DrugBank","id":"DB11871","properties":[{"key":"GenericName","value":"PF-00610355"}]},{"database":"DrugBank","id":"DB00925","properties":[{"key":"GenericName","value":"Phenoxybenzamine"}]},{"database":"DrugBank","id":"DB00397","properties":[{"key":"GenericName","value":"Phenylpropanolamine"}]},{"database":"DrugBank","id":"DB20301","properties":[{"key":"GenericName","value":"Picumeterol"}]},{"database":"DrugBank","id":"DB00960","properties":[{"key":"GenericName","value":"Pindolol"}]},{"database":"DrugBank","id":"DB01291","properties":[{"key":"GenericName","value":"Pirbuterol"}]},{"database":"DrugBank","id":"DB01366","properties":[{"key":"GenericName","value":"Procaterol"}]},{"database":"DrugBank","id":"DB01182","properties":[{"key":"GenericName","value":"Propafenone"}]},{"database":"DrugBank","id":"DB00571","properties":[{"key":"GenericName","value":"Propranolol"}]},{"database":"DrugBank","id":"DB06814","properties":[{"key":"GenericName","value":"Protokylol"}]},{"database":"DrugBank","id":"DB00852","properties":[{"key":"GenericName","value":"Pseudoephedrine"}]},{"database":"DrugBank","id":"DB01917","properties":[{"key":"GenericName","value":"Putrescine"}]},{"database":"DrugBank","id":"DB06483","properties":[{"key":"GenericName","value":"PW2101"}]},{"database":"DrugBank","id":"DB11124","properties":[{"key":"GenericName","value":"Racepinephrine"}]},{"database":"DrugBank","id":"DB12846","properties":[{"key":"GenericName","value":"Reproterol"}]},{"database":"DrugBank","id":"DB00867","properties":[{"key":"GenericName","value":"Ritodrine"}]},{"database":"DrugBank","id":"DB00938","properties":[{"key":"GenericName","value":"Salmeterol"}]},{"database":"DrugBank","id":"DB20962","properties":[{"key":"GenericName","value":"Sibenadet"}]},{"database":"DrugBank","id":"DB00489","properties":[{"key":"GenericName","value":"Sotalol"}]},{"database":"DrugBank","id":"DB03566","properties":[{"key":"GenericName","value":"Spermidine"}]},{"database":"DrugBank","id":"DB00127","properties":[{"key":"GenericName","value":"Spermine"}]},{"database":"DrugBank","id":"DB00871","properties":[{"key":"GenericName","value":"Terbutaline"}]},{"database":"DrugBank","id":"DB00373","properties":[{"key":"GenericName","value":"Timolol"}]},{"database":"DrugBank","id":"DB00726","properties":[{"key":"GenericName","value":"Trimipramine"}]},{"database":"DrugBank","id":"DB12248","properties":[{"key":"GenericName","value":"Tulobuterol"}]},{"database":"DrugBank","id":"DB09082","properties":[{"key":"GenericName","value":"Vilanterol"}]},{"database":"DrugBank","id":"DB09185","properties":[{"key":"GenericName","value":"Viloxazine"}]},{"database":"DrugCentral","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"29","properties":[{"key":"Description","value":"-"}]},{"database":"MoonDB","id":"P07550","properties":[{"key":"Type","value":"Predicted"}]},{"database":"TCDB","id":"9.A.14.3.5","properties":[{"key":"FamilyName","value":"the g-protein-coupled receptor (gpcr) family"}]},{"database":"GlyCosmos","id":"P07550","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"P07550","properties":[{"key":"glycosylation","value":"4 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ADRB2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"296439450","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000305372","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52013","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P07550","properties":[{"key":"antibodies","value":"44 sequenced antibodies"}]},{"database":"Antibodypedia","id":"15959","properties":[{"key":"antibodies","value":"1166 antibodies from 46 providers"}]},{"database":"DNASU","id":"154","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000305988.6","properties":[{"key":"ProteinId","value":"ENSP00000305372.4"},{"key":"GeneId","value":"ENSG00000169252.6"}]},{"database":"GeneID","id":"154","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:154","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000305988.6","properties":[{"key":"ProteinId","value":"ENSP00000305372.4"},{"key":"RefSeqNucleotideId","value":"NM_000024.6"},{"key":"RefSeqProteinId","value":"NP_000015.2"}]},{"database":"AGR","id":"HGNC:286","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA39","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"154","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"154","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ADRB2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:286","properties":[{"key":"GeneName","value":"ADRB2"}]},{"database":"HPA","id":"ENSG00000169252","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (breast, skin)"}]},{"database":"MalaCards","id":"ADRB2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"109690","properties":[{"key":"Type","value":"gene+phenotype"}]},{"database":"OpenTargets","id":"ENSG00000169252","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000169252","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3656","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000159538","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_11_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CEFWISI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5975661at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P07550","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-390696","properties":[{"key":"PathwayName","value":"Adrenoceptors"}]},{"database":"Reactome","id":"R-HSA-418555","properties":[{"key":"PathwayName","value":"G alpha (s) signalling events"}]},{"database":"Reactome","id":"R-HSA-5689880","properties":[{"key":"PathwayName","value":"Ub-specific processing proteases"}]},{"database":"Reactome","id":"R-HSA-8856825","properties":[{"key":"PathwayName","value":"Cargo recognition for clathrin-mediated endocytosis"}]},{"database":"Reactome","id":"R-HSA-8856828","properties":[{"key":"PathwayName","value":"Clathrin-mediated endocytosis"}]},{"database":"SignaLink","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000169252","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"154","properties":[{"key":"hits","value":"10 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"ADRB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P07550","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Beta-2_adrenergic_receptor","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"154","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P07550","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P07550","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"P07550","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000169252","properties":[{"key":"ExpressionPatterns","value":"Expressed in cartilage tissue and 162 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P07550","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016324","properties":[{"key":"GoTerm","value":"C:apical plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030669","properties":[{"key":"GoTerm","value":"C:clathrin-coated endocytic vesicle membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005768","properties":[{"key":"GoTerm","value":"C:endosome"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10734107"}]},{"database":"GO","id":"GO:0010008","properties":[{"key":"GoTerm","value":"C:endosome membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27481942"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9507004"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"NAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20395454"}]},{"database":"GO","id":"GO:0098992","properties":[{"key":"GoTerm","value":"C:neuronal dense core vesicle"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23166351"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27481942"}]},{"database":"GO","id":"GO:0043235","properties":[{"key":"GoTerm","value":"C:signaling receptor complex"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15123695"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23382219"}]},{"database":"GO","id":"GO:0008179","properties":[{"key":"GoTerm","value":"F:adenylate cyclase binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001540","properties":[{"key":"GoTerm","value":"F:amyloid-beta binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20395454"}]},{"database":"GO","id":"GO:0004941","properties":[{"key":"GoTerm","value":"F:beta2-adrenergic receptor activity"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15123695"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19710023"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15518545"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19763081"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20590567"}]},{"database":"GO","id":"GO:0051380","properties":[{"key":"GoTerm","value":"F:norepinephrine binding"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15123695"}]},{"database":"GO","id":"GO:0015459","properties":[{"key":"GoTerm","value":"F:potassium channel regulator activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12297500"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IPI:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15123695"}]},{"database":"GO","id":"GO:0044877","properties":[{"key":"GoTerm","value":"F:protein-containing complex binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20395454"}]},{"database":"GO","id":"GO:0071880","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-activating adrenergic receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15123695"}]},{"database":"GO","id":"GO:0071881","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-inhibiting adrenergic receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007188","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"2823249"}]},{"database":"GO","id":"GO:0071875","properties":[{"key":"GoTerm","value":"P:adrenergic receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19710023"}]},{"database":"GO","id":"GO:0098990","properties":[{"key":"GoTerm","value":"P:AMPA selective glutamate receptor signaling pathway"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"20395454"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1371121"}]},{"database":"GO","id":"GO:1904646","properties":[{"key":"GoTerm","value":"P:cellular response to amyloid-beta"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"20395454"}]},{"database":"GO","id":"GO:0008333","properties":[{"key":"GoTerm","value":"P:endosome to lysosome transport"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9507004"}]},{"database":"GO","id":"GO:0010667","properties":[{"key":"GoTerm","value":"P:negative regulation of cardiac muscle cell apoptotic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045744","properties":[{"key":"GoTerm","value":"P:negative regulation of G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15123695"}]},{"database":"GO","id":"GO:0002025","properties":[{"key":"GoTerm","value":"P:norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:1901098","properties":[{"key":"GoTerm","value":"P:positive regulation of autophagosome maturation"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23708524"}]},{"database":"GO","id":"GO:0010666","properties":[{"key":"GoTerm","value":"P:positive regulation of cardiac muscle cell apoptotic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0106134","properties":[{"key":"GoTerm","value":"P:positive regulation of cardiac muscle cell contraction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0120162","properties":[{"key":"GoTerm","value":"P:positive regulation of cold-induced thermogenesis"},{"key":"GoEvidenceType","value":"ISS:YuBioLab"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"12387862"}]},{"database":"GO","id":"GO:1900451","properties":[{"key":"GoTerm","value":"P:positive regulation of glutamate receptor signaling pathway"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"20395454"}]},{"database":"GO","id":"GO:1904504","properties":[{"key":"GoTerm","value":"P:positive regulation of lipophagy"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23708524"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15123695"}]},{"database":"GO","id":"GO:0061885","properties":[{"key":"GoTerm","value":"P:positive regulation of mini excitatory postsynaptic potential"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006898","properties":[{"key":"GoTerm","value":"P:receptor-mediated endocytosis"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15123695"}]},{"database":"GO","id":"GO:0006940","properties":[{"key":"GoTerm","value":"P:regulation of smooth muscle contraction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:1990911","properties":[{"key":"GoTerm","value":"P:response to psychosocial stress"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20395454"}]},{"database":"CDD","id":"cd15957","properties":[{"key":"EntryName","value":"7tmA_Beta2_AR"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP03692","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000057","properties":[{"key":"EntryName","value":"Beta-1 adrenergic receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002233","properties":[{"key":"EntryName","value":"ADR_fam"}]},{"database":"InterPro","id":"IPR000332","properties":[{"key":"EntryName","value":"ADRB2_rcpt"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR24248","properties":[{"key":"EntryName","value":"ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24248:SF21","properties":[{"key":"EntryName","value":"BETA-2 ADRENERGIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01103","properties":[{"key":"EntryName","value":"ADRENERGICR"}]},{"database":"PRINTS","id":"PR00562","properties":[{"key":"EntryName","value":"ADRENRGCB2AR"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SMART","id":"SM01381","properties":[{"key":"EntryName","value":"7TM_GPCR_Srsx"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL","length":413,"molWeight":46459,"crc64":"408C22731C6EDFBE","md5":"3E9D25347D93E5C2B71F7D8151DD1E9C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":46,"SUBCELLULAR LOCATION":1,"PTM":5,"POLYMORPHISM":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Region":1,"Motif":1,"Compositional bias":1,"Binding site":12,"Modified residue":10,"Lipidation":2,"Glycosylation":2,"Disulfide bond":2,"Natural variant":9,"Mutagenesis":12,"Sequence conflict":4,"Beta strand":7,"Helix":17,"Turn":3},"uniParcId":"UPI000013EAD0"}}