{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P06493","secondaryAccessions":["A8K7C4","C9J497","O60764"],"uniProtkbId":"CDK1_HUMAN","entryAudit":{"firstPublicDate":"1988-01-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-05-31","entryVersion":282,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cyclin-dependent kinase 1"},"shortNames":[{"value":"CDK1"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2188730"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23355470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2344612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26829474"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30704899"}],"value":"2.7.11.22"},{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11440"}],"value":"2.7.11.23"}]},"alternativeNames":[{"fullName":{"value":"Cell division control protein 2 homolog"}},{"fullName":{"value":"Cell division protein kinase 1"}},{"fullName":{"value":"p34 protein kinase"}}]},"genes":[{"geneName":{"value":"CDK1"},"synonyms":[{"value":"CDC2"},{"value":"CDC28A"},{"value":"CDKN1"},{"value":"P34CDC2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11440"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P39951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16407259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16933150"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17459720"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18356527"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18480403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19202191"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19509060"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19917720"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20171170"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20360007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20395957"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20935635"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20937773"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21063390"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2188730"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22411829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23355470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2344612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23601106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23602554"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25012651"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25556658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26549230"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26829474"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27238018"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27814491"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28479321"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30139873"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30704899"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30723163"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31279575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31804178"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32351706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32491969"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34741373"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37788673"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41100585"}],"value":"Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899, PubMed:40440427). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, ASB7, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, UHRF1, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS, GLI2 and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:22411829, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:31279575, PubMed:32351706, PubMed:34741373, PubMed:40440427). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (PubMed:41100585). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21516087"}],"value":"(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.22","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19202191"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2188730"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23355470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2344612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26829474"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30704899"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31279575"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.22","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23355470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26829474"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30704899"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10216"},{"database":"Rhea","id":"RHEA-COMP:11321"},{"database":"Rhea","id":"RHEA-COMP:11322"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43176"},{"database":"ChEBI","id":"CHEBI:68546"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.23","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11440"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17459720"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20360007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30139873"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41100585"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7569953"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9030781"}],"value":"Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it (PubMed:20360007, PubMed:7569953). Binding to cyclin-B is required for relocation of cyclin-kinase complexes to the nucleus for activation (PubMed:20360007, PubMed:7569953). Activated by CAK/CDK7-mediated phosphorylation on Thr-161, and reciprocally phosphorylates its activating kinase CDK7 (PubMed:20360007, PubMed:41100585). CDC25-mediated dephosphorylation of inhibitory phosphorylation on Thr-14 and Tyr-15 is required for full activation (PubMed:20360007, PubMed:7569953). Activity is restricted during S-phase in an ATR-dependent manner to prevent premature entry into G2 (PubMed:30139873). Repressed by the CDK inhibitors CDKN1A/p21 and CDKN1B/p27 during the G1 phase and by CDKN1A/p21 at the G1-S checkpoint upon DNA damage. Transient activation by rapid and transient dephosphorylation at Tyr-15 triggered by TGFB1 (PubMed:17459720). Inhibited by flavopiridol and derivatives, pyrimidine derivatives, pyridine derivatives, purine derivatives, staurosporine, paullones, oxoindoles, indazole analogs, indolin-2-ones, pyrazolo[3,4-b]pyridines, imidazo[1,2-a]pyridine (AZ703), thiazolinone analogs(RO-3306), thiazol urea, macrocyclic quinoxalin-2-one, pyrrolo[2,3-a]carbazole, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine (Dinaciclib, SCH 727965), 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), olomoucine, AG-024322, AT-7519, P276-00, R547/Ro-4584820 and SNS-032/BMS-387032 (PubMed:9030781)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12775724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15145941"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17459720"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20360007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21406398"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2188730"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2344612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25556658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27238018"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9242535"}],"value":"Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin (PubMed:20360007). The cyclin subunit imparts substrate specificity to the complex (PubMed:20360007). Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex known as maturation promoting factor (MPF) (PubMed:20360007, PubMed:2188730, PubMed:2344612). Promotes G2-M transition when in complex with a cyclin-B (PubMed:20360007). Can also form CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro (PubMed:17459720). Associates with cyclins-A and B1 during S-phase in regenerating hepatocytes (PubMed:20360007). Interacts with DLGAP5 (PubMed:15145941). Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27 (By similarity). Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase (PubMed:12775724). Interacts with FANCC (PubMed:9242535). Interacts with CEP63; this interaction recruits CDK1 to centrosomes (PubMed:21406398). Interacts with CENPA (PubMed:25556658). Interacts with NR1D1 (PubMed:27238018). Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9515786"}],"value":"Unable to complex with cyclin-B1 and also fails to bind to CDKN1A/p21"}],"commentType":"SUBUNIT","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31852787"}],"value":"(Microbial infection) Interacts with severe fever with thrombocytopenia syndrome virus (SFTSV) NSs; this interaction is inclusion body dependent, it inhibits the formation and nuclear import of the cyclin B1-CDK1 complex and leads to cell cycle arrest"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"Q86V81","geneName":"ALYREF","intActId":"EBI-347640"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"O15392","geneName":"BIRC5","intActId":"EBI-518823"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P14635","geneName":"CCNB1","intActId":"EBI-495332"},"numberOfExperiments":30,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P30307","geneName":"CDC25C","intActId":"EBI-974439"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"Q99741","geneName":"CDC6","intActId":"EBI-374862"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P38936","geneName":"CDKN1A","intActId":"EBI-375077"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P46527","geneName":"CDKN1B","intActId":"EBI-519280"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P61024","geneName":"CKS1B","intActId":"EBI-456371"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"O75618-1","geneName":"DEDD","intActId":"EBI-15621191"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P36957","geneName":"DLST","intActId":"EBI-351007"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P19525","geneName":"EIF2AK2","intActId":"EBI-640775"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"Q12778","geneName":"FOXO1","intActId":"EBI-1108782"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"O95835","geneName":"LATS1","intActId":"EBI-444209"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P27986-2","geneName":"PIK3R1","intActId":"EBI-9090282"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"Q99640","geneName":"PKMYT1","intActId":"EBI-495308"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"O43508","geneName":"TNFSF12","intActId":"EBI-6932080"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P0CG48","geneName":"UBC","intActId":"EBI-3390054"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P21796","geneName":"VDAC1","intActId":"EBI-354158"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P06493","intActId":"EBI-444308"},"interactantTwo":{"uniProtKBAccession":"P03070","intActId":"EBI-617698"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11440"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11440"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19917720"}],"value":"Mitochondrion","id":"SL-0173"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14654843"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}},{"location":{"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P06493-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"CDC2deltaT"}],"isoformIds":["P06493-2"],"sequenceIds":["VSP_021375"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9515786"}],"value":"Found in breast cancer tissues"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17459720"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18056467"}],"value":"Follows a cyclic expression; during interphase, accumulates gradually following G1, S to reach a critical threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis, but later repressed. Triggered by CKS1B during mitotic entry in breast cancer cells. Down-regulated under genotoxic stresses triggered by PKR/EIF2AK2-mediated phosphorylation"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19917613"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20360007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20395957"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29606300"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41100585"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7569953"}],"value":"Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity (PubMed:20360007, PubMed:41100585). Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation (PubMed:7569953). Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition) (PubMed:20360007). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2 (PubMed:20360007, PubMed:7569953). By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated (PubMed:20360007). Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition (PubMed:20360007). Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry (PubMed:29606300). Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation (PubMed:29606300). Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress (PubMed:20395957). This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest (PubMed:20395957). In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint (PubMed:19917613)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20395957"}],"value":"Polyubiquitinated upon genotoxic stress (PubMed:20395957)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21517772"}],"value":"As a key regulator of the cell cycle, CDK1 is a potent therapeutic target for inhibitors in cancer treatment"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"EAW54204.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Cyclin-dependent kinase 1","featureId":"PRO_0000085724"},{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}]},{"type":"Active site","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Phosphotyrosine; by PKR","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20395957"}]},{"type":"Modified residue","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11440"}]},{"type":"Modified residue","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Phosphothreonine; by PKMYT1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7569953"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"Phosphotyrosine; by PKMYT1, WEE1, WEE2 and PKC/PRKCD","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19917613"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29606300"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7569953"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Modified residue","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"}]},{"type":"Modified residue","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"Phosphothreonine; by CAK","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20360007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41100585"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"9SKQ"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Modified residue","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Modified residue","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"N6-succinyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11440"}]},{"type":"Modified residue","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Cross-link","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9515786"}],"featureId":"VSP_021375","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Constitutive polyubiquitination.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20395957"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D","E"]}},{"type":"Mutagenesis","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"Abnormal cell cycle exhibiting only M-phase without completing either karyokinesis or cytokinesis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18480403"}],"alternativeSequence":{"originalSequence":"TY","alternativeSequences":["AF"]}},{"type":"Helix","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Beta strand","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Beta strand","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Turn","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Beta strand","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Beta strand","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Beta strand","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Beta strand","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LQF"}]},{"type":"Helix","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Turn","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Beta strand","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Beta strand","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9SKQ"}]},{"type":"Beta strand","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU6"}]},{"type":"Beta strand","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Turn","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4YC6"}]},{"type":"Helix","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU6"}]},{"type":"Helix","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Beta strand","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4YC6"}]},{"type":"Helix","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Turn","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Turn","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GU2"}]},{"type":"Helix","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4YC3"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-1183","category":"Molecular function","name":"Host cell receptor for virus entry"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"3553962","citationType":"journal article","authors":["Lee M.G.","Nurse P."],"citationCrossReferences":[{"database":"PubMed","id":"3553962"},{"database":"DOI","id":"10.1038/327031a0"}],"title":"Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.","publicationDate":"1987","journal":"Nature","firstPage":"31","lastPage":"35","volume":"327"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"9515786","citationType":"journal article","authors":["Ohta T.","Okamoto K.","Isohashi F.","Shibata K.","Fukuda M.","Yamaguchi S.","Xiong Y."],"citationCrossReferences":[{"database":"PubMed","id":"9515786"}],"title":"T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21.","publicationDate":"1998","journal":"Cancer Res.","firstPage":"1095","lastPage":"1098","volume":"58"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Mammary cancer","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":5,"citation":{"id":"CI-6QALQ4R1NTRR0","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"MAY-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.R.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.S.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.M.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"3289755","citationType":"journal article","authors":["Draetta G.","Beach D."],"citationCrossReferences":[{"database":"PubMed","id":"3289755"},{"database":"DOI","id":"10.1016/0092-8674(88)90175-4"}],"title":"Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement.","publicationDate":"1988","journal":"Cell","firstPage":"17","lastPage":"26","volume":"54"},"referencePositions":["ASSOCIATION WITH P13"]},{"referenceNumber":10,"citation":{"id":"2344612","citationType":"journal article","authors":["Heald R.","McKeon F."],"citationCrossReferences":[{"database":"PubMed","id":"2344612"},{"database":"DOI","id":"10.1016/0092-8674(90)90470-y"}],"title":"Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.","publicationDate":"1990","journal":"Cell","firstPage":"579","lastPage":"589","volume":"61"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","IDENTIFICATION IN THE MPF COMPLEX"]},{"referenceNumber":11,"citation":{"id":"2188730","citationType":"journal article","authors":["Ward G.E.","Kirschner M.W."],"citationCrossReferences":[{"database":"PubMed","id":"2188730"},{"database":"DOI","id":"10.1016/0092-8674(90)90469-u"}],"title":"Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C.","publicationDate":"1990","journal":"Cell","firstPage":"561","lastPage":"577","volume":"61"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","IDENTIFICATION IN THE MPF COMPLEX"]},{"referenceNumber":12,"citation":{"id":"7569953","citationType":"journal article","authors":["Mueller P.R.","Coleman T.R.","Kumagai A.","Dunphy W.G."],"citationCrossReferences":[{"database":"PubMed","id":"7569953"},{"database":"DOI","id":"10.1126/science.270.5233.86"}],"title":"Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.","publicationDate":"1995","journal":"Science","firstPage":"86","lastPage":"90","volume":"270"},"referencePositions":["ACTIVITY REGULATION","PHOSPHORYLATION AT THR-14 AND TYR-15 BY PKMYT1"]},{"referenceNumber":13,"citation":{"id":"9242535","citationType":"journal article","authors":["Kupfer G.M.","Yamashita T.","Naf D.","Suliman A.","Asano S.","D'Andrea A.D."],"citationCrossReferences":[{"database":"PubMed","id":"9242535"},{"database":"DOI","id":"10.1182/blood.v90.3.1047"}],"title":"The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2.","publicationDate":"1997","journal":"Blood","firstPage":"1047","lastPage":"1054","volume":"90"},"referencePositions":["INTERACTION WITH FANCC"]},{"referenceNumber":14,"citation":{"id":"9030781","citationType":"journal article","authors":["Meijer L.","Borgne A.","Mulner O.","Chong J.P.J.","Blow J.J.","Inagaki N.","Inagaki M.","Delcros J.-G.","Moulinoux J.-P."],"citationCrossReferences":[{"database":"PubMed","id":"9030781"},{"database":"DOI","id":"10.1111/j.1432-1033.1997.t01-2-00527.x"}],"title":"Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.","publicationDate":"1997","journal":"Eur. J. Biochem.","firstPage":"527","lastPage":"536","volume":"243"},"referencePositions":["ACTIVITY REGULATION BY ROSCOVITINE AND OLOMOUCINE"]},{"referenceNumber":15,"citation":{"id":"12775724","citationType":"journal article","authors":["Rosse C.","L'Hoste S.","Offner N.","Picard A.","Camonis J."],"citationCrossReferences":[{"database":"PubMed","id":"12775724"},{"database":"DOI","id":"10.1074/jbc.m302191200"}],"title":"RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"30597","lastPage":"30604","volume":"278"},"referencePositions":["INTERACTION WITH RALBP1"]},{"referenceNumber":16,"citation":{"id":"14654843","citationType":"journal article","authors":["Andersen J.S.","Wilkinson C.J.","Mayor T.","Mortensen P.","Nigg E.A.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"14654843"},{"database":"DOI","id":"10.1038/nature02166"}],"title":"Proteomic characterization of the human centrosome by protein correlation profiling.","publicationDate":"2003","journal":"Nature","firstPage":"570","lastPage":"574","volume":"426"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY","SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Lymphoblast","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"15145941","citationType":"journal article","authors":["Hsu J.-M.","Lee Y.-C.G.","Yu C.-T.R.","Huang C.-Y.F."],"citationCrossReferences":[{"database":"PubMed","id":"15145941"},{"database":"DOI","id":"10.1074/jbc.m404950200"}],"title":"Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"32592","lastPage":"32602","volume":"279"},"referencePositions":["INTERACTION WITH DLGAP5"]},{"referenceNumber":18,"citation":{"id":"16407259","citationType":"journal article","authors":["Qiao M.","Shapiro P.","Fosbrink M.","Rus H.","Kumar R.","Passaniti A."],"citationCrossReferences":[{"database":"PubMed","id":"16407259"},{"database":"DOI","id":"10.1074/jbc.m508162200"}],"title":"Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"7118","lastPage":"7128","volume":"281"},"referencePositions":["FUNCTION AS RUNX2 KINASE"]},{"referenceNumber":19,"citation":{"id":"16371510","citationType":"journal article","authors":["Fourest-Lieuvin A.","Peris L.","Gache V.","Garcia-Saez I.","Juillan-Binard C.","Lantez V.","Job D."],"citationCrossReferences":[{"database":"PubMed","id":"16371510"},{"database":"DOI","id":"10.1091/mbc.e05-07-0621"}],"title":"Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.","publicationDate":"2006","journal":"Mol. Biol. Cell","firstPage":"1041","lastPage":"1050","volume":"17"},"referencePositions":["FUNCTION AS BETA-TUBULINS KINASE"]},{"referenceNumber":20,"citation":{"id":"18056467","citationType":"journal article","authors":["Westbrook L.","Manuvakhova M.","Kern F.G.","Estes N.R. II","Ramanathan H.N.","Thottassery J.V."],"citationCrossReferences":[{"database":"PubMed","id":"18056467"},{"database":"DOI","id":"10.1158/0008-5472.can-06-4173"}],"title":"Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells.","publicationDate":"2007","journal":"Cancer Res.","firstPage":"11393","lastPage":"11401","volume":"67"},"referencePositions":["INDUCTION BY CKS1B"]},{"referenceNumber":21,"citation":{"id":"17459720","citationType":"journal article","authors":["Hu X.","Cui D.","Moscinski L.C.","Zhang X.","Maccachero V.","Zuckerman K.S."],"citationCrossReferences":[{"database":"PubMed","id":"17459720"},{"database":"DOI","id":"10.1016/j.cyto.2007.03.009"}],"title":"TGFbeta regulates the expression and activities of G2 checkpoint kinases in human myeloid leukemia cells.","publicationDate":"2007","journal":"Cytokine","firstPage":"155","lastPage":"162","volume":"37"},"referencePositions":["FUNCTION AS RB1 KINASE","ACTIVITY REGULATION BY TGFB1","REPRESSION BY TGFB1"]},{"referenceNumber":22,"citation":{"id":"16933150","citationType":"journal article","authors":["Southwood C.M.","Peppi M.","Dryden S.","Tainsky M.A.","Gow A."],"citationCrossReferences":[{"database":"PubMed","id":"16933150"},{"database":"DOI","id":"10.1007/s11064-006-9127-6"}],"title":"Microtubule deacetylases, SirT2 and HDAC6, in the nervous system.","publicationDate":"2007","journal":"Neurochem. Res.","firstPage":"187","lastPage":"195","volume":"32"},"referencePositions":["FUNCTION AS SIRT2 KINASE","SUBCELLULAR LOCATION"]},{"referenceNumber":23,"citation":{"id":"18220336","citationType":"journal article","authors":["Cantin G.T.","Yi W.","Lu B.","Park S.K.","Xu T.","Lee J.-D.","Yates J.R. III"],"citationCrossReferences":[{"database":"PubMed","id":"18220336"},{"database":"DOI","id":"10.1021/pr0705441"}],"title":"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1346","lastPage":"1351","volume":"7"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"18480403","citationType":"journal article","authors":["Pomerening J.R.","Ubersax J.A.","Ferrell J.E. Jr."],"citationCrossReferences":[{"database":"PubMed","id":"18480403"},{"database":"DOI","id":"10.1091/mbc.e08-02-0172"}],"title":"Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.","publicationDate":"2008","journal":"Mol. Biol. Cell","firstPage":"3426","lastPage":"3441","volume":"19"},"referencePositions":["FUNCTION DURING THE M PHASE","MUTAGENESIS OF 14-THR-TYR-15"]},{"referenceNumber":25,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-19; SER-39; TYR-77 AND THR-222","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14 AND TYR-15","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"18356527","citationType":"journal article","authors":["Yuan Z.","Becker E.B.E.","Merlo P.","Yamada T.","DiBacco S.","Konishi Y.","Schaefer E.M.","Bonni A."],"citationCrossReferences":[{"database":"PubMed","id":"18356527"},{"database":"DOI","id":"10.1126/science.1152337"}],"title":"Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.","publicationDate":"2008","journal":"Science","firstPage":"1665","lastPage":"1668","volume":"319"},"referencePositions":["FUNCTION AS FOXO1 KINASE"]},{"referenceNumber":28,"citation":{"id":"19202191","citationType":"journal article","authors":["Huertas P.","Jackson S.P."],"citationCrossReferences":[{"database":"PubMed","id":"19202191"},{"database":"DOI","id":"10.1074/jbc.m808906200"}],"title":"Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"9558","lastPage":"9565","volume":"284"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":29,"citation":{"id":"19509060","citationType":"journal article","authors":["Zhang X.","Chen Q.","Feng J.","Hou J.","Yang F.","Liu J.","Jiang Q.","Zhang C."],"citationCrossReferences":[{"database":"PubMed","id":"19509060"},{"database":"DOI","id":"10.1242/jcs.042747"}],"title":"Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.","publicationDate":"2009","journal":"J. Cell Sci.","firstPage":"2240","lastPage":"2251","volume":"122"},"referencePositions":["FUNCTION AS NEDD1 KINASE"]},{"referenceNumber":30,"citation":{"id":"19369195","citationType":"journal article","authors":["Oppermann F.S.","Gnad F.","Olsen J.V.","Hornberger R.","Greff Z.","Keri G.","Mann M.","Daub H."],"citationCrossReferences":[{"database":"PubMed","id":"19369195"},{"database":"DOI","id":"10.1074/mcp.m800588-mcp200"}],"title":"Large-scale proteomics analysis of the human kinome.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"1751","lastPage":"1764","volume":"8"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-19; SER-39; SER-178; THR-222 AND SER-248","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":31,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; TYR-15 AND THR-161","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":32,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-6","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":33,"citation":{"id":"20171170","citationType":"journal article","authors":["Nakamura A.","Naito M.","Arai H.","Fujita N."],"citationCrossReferences":[{"database":"PubMed","id":"20171170"},{"database":"DOI","id":"10.1016/j.bbrc.2010.02.103"}],"title":"Mitotic phosphorylation of Aki1 at Ser208 by cyclin B1-Cdk1 complex.","publicationDate":"2010","journal":"Biochem. Biophys. Res. Commun.","firstPage":"872","lastPage":"876","volume":"393"},"referencePositions":["FUNCTION AS CC2D1A KINASE"]},{"referenceNumber":34,"citation":{"id":"20395957","citationType":"journal article","authors":["Yoon C.-H.","Miah M.A.","Kim K.P.","Bae Y.-S."],"citationCrossReferences":[{"database":"PubMed","id":"20395957"},{"database":"DOI","id":"10.1038/embor.2010.45"}],"title":"New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.","publicationDate":"2010","journal":"EMBO Rep.","firstPage":"393","lastPage":"399","volume":"11"},"referencePositions":["FUNCTION IN G2 ARREST UPON DNA DAMAGE","PHOSPHORYLATION AT TYR-4 BY PKR/EIF2AK2","POLYUBIQUITINATION","MUTAGENESIS OF TYR-4"]},{"referenceNumber":35,"citation":{"id":"19917613","citationType":"journal article","authors":["LaGory E.L.","Sitailo L.A.","Denning M.F."],"citationCrossReferences":[{"database":"PubMed","id":"19917613"},{"database":"DOI","id":"10.1074/jbc.m109.055392"}],"title":"The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"1879","lastPage":"1887","volume":"285"},"referencePositions":["PHOSPHORYLATION AT TYR-15"]},{"referenceNumber":36,"citation":{"id":"20360007","citationType":"journal article","authors":["Timofeev O.","Cizmecioglu O.","Settele F.","Kempf T.","Hoffmann I."],"citationCrossReferences":[{"database":"PubMed","id":"20360007"},{"database":"DOI","id":"10.1074/jbc.m109.096552"}],"title":"Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"16978","lastPage":"16990","volume":"285"},"referencePositions":["FUNCTION IN G2-M TRANSITION","ACTIVITY REGULATION","DEPHOSPHORYLATION AT THR-14 AND TYR-15 BY CDC25","PHOSPHORYLATION AT THR-161 BY CDK7/CAK","INTERACTION WITH B-CYCLIN"]},{"referenceNumber":37,"citation":{"id":"19917720","citationType":"journal article","authors":["Terrano D.T.","Upreti M.","Chambers T.C."],"citationCrossReferences":[{"database":"PubMed","id":"19917720"},{"database":"DOI","id":"10.1128/mcb.00882-09"}],"title":"Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.","publicationDate":"2010","journal":"Mol. Cell. Biol.","firstPage":"640","lastPage":"656","volume":"30"},"referencePositions":["FUNCTION AS BCL-XL/BCL2L1 KINASE","SUBCELLULAR LOCATION"]},{"referenceNumber":38,"citation":{"id":"20937773","citationType":"journal article","authors":["Matthess Y.","Raab M.","Sanhaji M.","Lavrik I.N.","Strebhardt K."],"citationCrossReferences":[{"database":"PubMed","id":"20937773"},{"database":"DOI","id":"10.1128/mcb.00731-10"}],"title":"Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.","publicationDate":"2010","journal":"Mol. Cell. Biol.","firstPage":"5726","lastPage":"5740","volume":"30"},"referencePositions":["FUNCTION AS CASP8 KINASE"]},{"referenceNumber":39,"citation":{"id":"20935635","citationType":"journal article","authors":["Chen S.","Bohrer L.R.","Rai A.N.","Pan Y.","Gan L.","Zhou X.","Bagchi A.","Simon J.A.","Huang H."],"citationCrossReferences":[{"database":"PubMed","id":"20935635"},{"database":"DOI","id":"10.1038/ncb2116"}],"title":"Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.","publicationDate":"2010","journal":"Nat. Cell Biol.","firstPage":"1108","lastPage":"1114","volume":"12"},"referencePositions":["FUNCTION AS EZH2 KINASE"]},{"referenceNumber":40,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-161","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":41,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":42,"citation":{"id":"21406398","citationType":"journal article","authors":["Loffler H.","Fechter A.","Matuszewska M.","Saffrich R.","Mistrik M.","Marhold J.","Hornung C.","Westermann F.","Bartek J.","Kramer A."],"citationCrossReferences":[{"database":"PubMed","id":"21406398"},{"database":"DOI","id":"10.1158/0008-5472.can-10-2684"}],"title":"Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.","publicationDate":"2011","journal":"Cancer Res.","firstPage":"2129","lastPage":"2139","volume":"71"},"referencePositions":["INTERACTION WITH CEP63","SUBCELLULAR LOCATION"]},{"referenceNumber":43,"citation":{"id":"21063390","citationType":"journal article","authors":["Itoh G.","Kanno S.","Uchida K.S.","Chiba S.","Sugino S.","Watanabe K.","Mizuno K.","Yasui A.","Hirota T.","Tanaka K."],"citationCrossReferences":[{"database":"PubMed","id":"21063390"},{"database":"DOI","id":"10.1038/emboj.2010.276"}],"title":"CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.","publicationDate":"2011","journal":"EMBO J.","firstPage":"130","lastPage":"144","volume":"30"},"referencePositions":["FUNCTION AS CHAMP1 KINASE"]},{"referenceNumber":44,"citation":{"id":"16236519","citationType":"journal article","authors":["Malumbres M.","Barbacid M."],"citationCrossReferences":[{"database":"PubMed","id":"16236519"},{"database":"DOI","id":"10.1016/j.tibs.2005.09.005"}],"title":"Mammalian cyclin-dependent kinases.","publicationDate":"2005","journal":"Trends Biochem. Sci.","firstPage":"630","lastPage":"641","volume":"30"},"referencePositions":["REVIEW ON SUBSTRATES","GENE FAMILY"]},{"referenceNumber":45,"citation":{"id":"19364923","citationType":"journal article","authors":["Lindqvist A.","Rodriguez-Bravo V.","Medema R.H."],"citationCrossReferences":[{"database":"PubMed","id":"19364923"},{"database":"DOI","id":"10.1083/jcb.200812045"}],"title":"The decision to enter mitosis: feedback and redundancy in the mitotic entry network.","publicationDate":"2009","journal":"J. Cell Biol.","firstPage":"193","lastPage":"202","volume":"185"},"referencePositions":["REVIEW ON SUBCELLULAR TRANSLOCATION"]},{"referenceNumber":46,"citation":{"id":"19238148","citationType":"journal article","authors":["Malumbres M.","Barbacid M."],"citationCrossReferences":[{"database":"PubMed","id":"19238148"},{"database":"DOI","id":"10.1038/nrc2602"}],"title":"Cell cycle, CDKs and cancer: a changing paradigm.","publicationDate":"2009","journal":"Nat. Rev. Cancer","firstPage":"153","lastPage":"166","volume":"9"},"referencePositions":["REVIEW ON CELL CYCLE CONTROL AND INHIBITORS","GENE FAMILY"]},{"referenceNumber":47,"citation":{"id":"21535261","citationType":"journal article","authors":["Hu X.","Moscinski L.C."],"citationCrossReferences":[{"database":"PubMed","id":"21535261"},{"database":"DOI","id":"10.1111/j.1365-2184.2011.00753.x"}],"title":"Cdc2: a monopotent or pluripotent CDK?","publicationDate":"2011","journal":"Cell Prolif.","firstPage":"205","lastPage":"211","volume":"44"},"referencePositions":["REVIEW ON CELL CYCLE CONTROL"]},{"referenceNumber":48,"citation":{"id":"21517772","citationType":"journal article","authors":["Wang Q.","Su L.","Liu N.","Zhang L.","Xu W.","Fang H."],"citationCrossReferences":[{"database":"PubMed","id":"21517772"},{"database":"DOI","id":"10.2174/092986711795590110"}],"title":"Cyclin dependent kinase 1 inhibitors: a review of recent progress.","publicationDate":"2011","journal":"Curr. Med. Chem.","firstPage":"2025","lastPage":"2043","volume":"18"},"referencePositions":["REVIEW ON CELL CYCLE CONTROL AND INHIBITORS"]},{"referenceNumber":49,"citation":{"id":"21655336","citationType":"journal article","authors":["Medema R.H.","Macurek L."],"citationCrossReferences":[{"database":"PubMed","id":"21655336"},{"database":"DOI","id":"10.3410/b3-10"}],"title":"Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer.","publicationDate":"2011","journal":"F1000 Biol. Rep.","firstPage":"10","lastPage":"10","volume":"3"},"referencePositions":["REVIEW ON CELL CYCLE CONTROL"]},{"referenceNumber":50,"citation":{"id":"21516087","citationType":"journal article","authors":["Lupberger J.","Zeisel M.B.","Xiao F.","Thumann C.","Fofana I.","Zona L.","Davis C.","Mee C.J.","Turek M.","Gorke S.","Royer C.","Fischer B.","Zahid M.N.","Lavillette D.","Fresquet J.","Cosset F.L.","Rothenberg S.M.","Pietschmann T.","Patel A.H.","Pessaux P.","Doffoel M.","Raffelsberger W.","Poch O.","McKeating J.A.","Brino L.","Baumert T.F."],"citationCrossReferences":[{"database":"PubMed","id":"21516087"},{"database":"DOI","id":"10.1038/nm.2341"}],"title":"EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.","publicationDate":"2011","journal":"Nat. Med.","firstPage":"589","lastPage":"595","volume":"17"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)"]},{"referenceNumber":51,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-161","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":52,"citation":{"id":"22411829","citationType":"journal article","authors":["Ma H.","Chen H.","Guo X.","Wang Z.","Sowa M.E.","Zheng L.","Hu S.","Zeng P.","Guo R.","Diao J.","Lan F.","Harper J.W.","Shi Y.G.","Xu Y.","Shi Y."],"citationCrossReferences":[{"database":"PubMed","id":"22411829"},{"database":"DOI","id":"10.1073/pnas.1116349109"}],"title":"M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4828","lastPage":"4833","volume":"109"},"referencePositions":["FUNCTION"]},{"referenceNumber":53,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":54,"citation":{"id":"23602554","citationType":"journal article","authors":["Cribier A.","Descours B.","Valadao A.L.","Laguette N.","Benkirane M."],"citationCrossReferences":[{"database":"PubMed","id":"23602554"},{"database":"DOI","id":"10.1016/j.celrep.2013.03.017"}],"title":"Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.","publicationDate":"2013","journal":"Cell Rep.","firstPage":"1036","lastPage":"1043","volume":"3"},"referencePositions":["FUNCTION"]},{"referenceNumber":55,"citation":{"id":"23601106","citationType":"journal article","authors":["White T.E.","Brandariz-Nunez A.","Valle-Casuso J.C.","Amie S.","Nguyen L.A.","Kim B.","Tuzova M.","Diaz-Griffero F."],"citationCrossReferences":[{"database":"PubMed","id":"23601106"},{"database":"DOI","id":"10.1016/j.chom.2013.03.005"}],"title":"The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.","publicationDate":"2013","journal":"Cell Host Microbe","firstPage":"441","lastPage":"451","volume":"13"},"referencePositions":["FUNCTION"]},{"referenceNumber":56,"citation":{"id":"23355470","citationType":"journal article","authors":["Schofield A.V.","Gamell C.","Suryadinata R.","Sarcevic B.","Bernard O."],"citationCrossReferences":[{"database":"PubMed","id":"23355470"},{"database":"DOI","id":"10.1074/jbc.m112.441048"}],"title":"Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation.","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"7907","lastPage":"7917","volume":"288"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":57,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; THR-141 AND THR-161","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":58,"citation":{"id":"25012651","citationType":"journal article","authors":["Takagi M.","Nishiyama Y.","Taguchi A.","Imamoto N."],"citationCrossReferences":[{"database":"PubMed","id":"25012651"},{"database":"DOI","id":"10.1074/jbc.m114.556647"}],"title":"Ki67 antigen contributes to the timely accumulation of protein phosphatase 1gamma on anaphase chromosomes.","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"22877","lastPage":"22887","volume":"289"},"referencePositions":["FUNCTION"]},{"referenceNumber":59,"citation":{"id":"26549230","citationType":"journal article","authors":["Mori Y.","Inoue Y.","Taniyama Y.","Tanaka S.","Terada Y."],"citationCrossReferences":[{"database":"PubMed","id":"26549230"},{"database":"DOI","id":"10.1016/j.bbrc.2015.11.004"}],"title":"Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis.","publicationDate":"2015","journal":"Biochem. Biophys. Res. Commun.","firstPage":"642","lastPage":"646","volume":"468"},"referencePositions":["FUNCTION"]},{"referenceNumber":60,"citation":{"id":"25556658","citationType":"journal article","authors":["Yu Z.","Zhou X.","Wang W.","Deng W.","Fang J.","Hu H.","Wang Z.","Li S.","Cui L.","Shen J.","Zhai L.","Peng S.","Wong J.","Dong S.","Yuan Z.","Ou G.","Zhang X.","Xu P.","Lou J.","Yang N.","Chen P.","Xu R.M.","Li G."],"citationCrossReferences":[{"database":"PubMed","id":"25556658"},{"database":"DOI","id":"10.1016/j.devcel.2014.11.030"}],"title":"Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.","publicationDate":"2015","journal":"Dev. Cell","firstPage":"68","lastPage":"81","volume":"32"},"referencePositions":["FUNCTION","INTERACTION WITH CENPA"]},{"referenceNumber":61,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":62,"citation":{"id":"27238018","citationType":"journal article","authors":["Zhao X.","Hirota T.","Han X.","Cho H.","Chong L.W.","Lamia K.","Liu S.","Atkins A.R.","Banayo E.","Liddle C.","Yu R.T.","Yates J.R. III","Kay S.A.","Downes M.","Evans R.M."],"citationCrossReferences":[{"database":"PubMed","id":"27238018"},{"database":"DOI","id":"10.1016/j.cell.2016.05.012"}],"title":"Circadian amplitude regulation via FBXW7-targeted REV-ERBalpha degradation.","publicationDate":"2016","journal":"Cell","firstPage":"1644","lastPage":"1657","volume":"165"},"referencePositions":["FUNCTION","INTERACTION WITH NR1D1"]},{"referenceNumber":63,"citation":{"id":"27814491","citationType":"journal article","authors":["Deshpande R.A.","Lee J.H.","Arora S.","Paull T.T."],"citationCrossReferences":[{"database":"PubMed","id":"27814491"},{"database":"DOI","id":"10.1016/j.molcel.2016.10.010"}],"title":"Nbs1 converts the human Mre11/Rad50 nuclease complex into an endo/exonuclease machine specific for protein-DNA adducts.","publicationDate":"2016","journal":"Mol. Cell","firstPage":"593","lastPage":"606","volume":"64"},"referencePositions":["FUNCTION"]},{"referenceNumber":64,"citation":{"id":"26829474","citationType":"journal article","authors":["Mo F.","Zhuang X.","Liu X.","Yao P.Y.","Qin B.","Su Z.","Zang J.","Wang Z.","Zhang J.","Dou Z.","Tian C.","Teng M.","Niu L.","Hill D.L.","Fang G.","Ding X.","Fu C.","Yao X."],"citationCrossReferences":[{"database":"PubMed","id":"26829474"},{"database":"DOI","id":"10.1038/nchembio.2017"}],"title":"Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation.","publicationDate":"2016","journal":"Nat. Chem. Biol.","firstPage":"226","lastPage":"232","volume":"12"},"referencePositions":["FUNCTION"]},{"referenceNumber":65,"citation":{"id":"28479321","citationType":"journal article","authors":["Zhang Q.","Sivakumar S.","Chen Y.","Gao H.","Yang L.","Yuan Z.","Yu H.","Liu H."],"citationCrossReferences":[{"database":"PubMed","id":"28479321"},{"database":"DOI","id":"10.1016/j.cub.2017.03.060"}],"title":"Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression.","publicationDate":"2017","journal":"Curr. Biol.","firstPage":"1477","lastPage":"1484","volume":"27"},"referencePositions":["FUNCTION"]},{"referenceNumber":66,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-6; LYS-9; LYS-20 AND LYS-139","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":67,"citation":{"id":"29606300","citationType":"journal article","authors":["Sang Q.","Li B.","Kuang Y.","Wang X.","Zhang Z.","Chen B.","Wu L.","Lyu Q.","Fu Y.","Yan Z.","Mao X.","Xu Y.","Mu J.","Li Q.","Jin L.","He L.","Wang L."],"citationCrossReferences":[{"database":"PubMed","id":"29606300"},{"database":"DOI","id":"10.1016/j.ajhg.2018.02.015"}],"title":"Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.","publicationDate":"2018","journal":"Am. J. Hum. Genet.","firstPage":"649","lastPage":"657","volume":"102"},"referencePositions":["PHOSPHORYLATION AT TYR-15"]},{"referenceNumber":68,"citation":{"id":"30139873","citationType":"journal article","authors":["Saldivar J.C.","Hamperl S.","Bocek M.J.","Chung M.","Bass T.E.","Cisneros-Soberanis F.","Samejima K.","Xie L.","Paulson J.R.","Earnshaw W.C.","Cortez D.","Meyer T.","Cimprich K.A."],"citationCrossReferences":[{"database":"PubMed","id":"30139873"},{"database":"DOI","id":"10.1126/science.aap9346"}],"title":"An intrinsic S/G2 checkpoint enforced by ATR.","publicationDate":"2018","journal":"Science","firstPage":"806","lastPage":"810","volume":"361"},"referencePositions":["FUNCTION","ACTIVITY REGULATION"]},{"referenceNumber":69,"citation":{"id":"31279575","citationType":"journal article","authors":["Han Y.","Wang B.","Cho Y.S.","Zhu J.","Wu J.","Chen Y.","Jiang J."],"citationCrossReferences":[{"database":"PubMed","id":"31279575"},{"database":"DOI","id":"10.1016/j.devcel.2019.06.008"}],"title":"Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.","publicationDate":"2019","journal":"Dev. Cell","firstPage":"610","lastPage":"626","volume":"50"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":70,"citation":{"id":"31804178","citationType":"journal article","authors":["Huis In 't Veld P.J.","Volkov V.A.","Stender I.D.","Musacchio A.","Dogterom M."],"citationCrossReferences":[{"database":"PubMed","id":"31804178"},{"database":"DOI","id":"10.7554/elife.49539"}],"title":"Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling.","publicationDate":"2019","journal":"Elife","firstPage":"e49539","lastPage":"e49539","volume":"8"},"referencePositions":["FUNCTION"]},{"referenceNumber":71,"citation":{"id":"30723163","citationType":"journal article","authors":["Luo J.","Yang B.","Xin G.","Sun M.","Zhang B.","Guo X.","Jiang Q.","Zhang C."],"citationCrossReferences":[{"database":"PubMed","id":"30723163"},{"database":"DOI","id":"10.1074/jbc.ra118.007164"}],"title":"The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules.","publicationDate":"2019","journal":"J. Biol. Chem.","firstPage":"5643","lastPage":"5656","volume":"294"},"referencePositions":["FUNCTION AS EML3 KINASE"]},{"referenceNumber":72,"citation":{"id":"30704899","citationType":"journal article","authors":["Cheng X.","Ma X.","Zhu Q.","Song D.","Ding X.","Li L.","Jiang X.","Wang X.","Tian R.","Su H.","Shen Z.","Chen S.","Liu T.","Gong W.","Liu W.","Sun Q."],"citationCrossReferences":[{"database":"PubMed","id":"30704899"},{"database":"DOI","id":"10.1016/j.molcel.2018.12.017"}],"title":"Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.","publicationDate":"2019","journal":"Mol. Cell","firstPage":"1","lastPage":"15","volume":"73"},"referencePositions":["FUNCTION"]},{"referenceNumber":73,"citation":{"id":"32351706","citationType":"journal article","authors":["Zhong L.","Hu M.M.","Bian L.J.","Liu Y.","Chen Q.","Shu H.B."],"citationCrossReferences":[{"database":"PubMed","id":"32351706"},{"database":"DOI","id":"10.1038/s41421-020-0162-2"}],"title":"Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis.","publicationDate":"2020","journal":"Cell Discov.","firstPage":"26","lastPage":"26","volume":"6"},"referencePositions":["FUNCTION AS CGAS KINASE"]},{"referenceNumber":74,"citation":{"id":"31852787","citationType":"journal article","authors":["Liu S.","Liu H.","Kang J.","Xu L.","Zhang K.","Li X.","Hou W.","Wang Z.","Wang T."],"citationCrossReferences":[{"database":"PubMed","id":"31852787"},{"database":"DOI","id":"10.1128/jvi.01575-19"}],"title":"The Severe Fever with Thrombocytopenia Syndrome Virus NSs Protein Interacts with CDK1 To Induce G2 Cell Cycle Arrest and Positively Regulate Viral Replication.","publicationDate":"2020","journal":"J. Virol.","firstPage":"0","lastPage":"0","volume":"94"},"referencePositions":["INTERACTION WITH SFTSV VIRUS NSS (MICROBIAL INFECTION)"]},{"referenceNumber":75,"citation":{"id":"32491969","citationType":"journal article","authors":["Zhang Q.","Hu L.","Chen Y.","Tian W.","Liu H."],"citationCrossReferences":[{"database":"PubMed","id":"32491969"},{"database":"DOI","id":"10.1091/mbc.e19-10-0569"}],"title":"Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis.","publicationDate":"2020","journal":"Mol. Biol. Cell","firstPage":"1892","lastPage":"1903","volume":"31"},"referencePositions":["FUNCTION"]},{"referenceNumber":76,"citation":{"id":"34741373","citationType":"journal article","authors":["Zhang E.","Chen S.","Tang H.","Fei C.","Yuan Z.","Mu X.","Qin Y.","Liu H.","Fan Y.","Tan M.","Wang X."],"citationCrossReferences":[{"database":"PubMed","id":"34741373"},{"database":"DOI","id":"10.1111/cas.15188"}],"title":"CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma.","publicationDate":"2022","journal":"Cancer Sci.","firstPage":"91","lastPage":"108","volume":"113"},"referencePositions":["FUNCTION"]},{"referenceNumber":77,"citation":{"id":"37788673","citationType":"journal article","authors":["Joo Y.K.","Black E.M.","Trier I.","Haakma W.","Zou L.","Kabeche L."],"citationCrossReferences":[{"database":"PubMed","id":"37788673"},{"database":"DOI","id":"10.1016/j.molcel.2023.09.003"}],"title":"ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei.","publicationDate":"2023","journal":"Mol. Cell","firstPage":"3642","lastPage":"3658","volume":"83"},"referencePositions":["FUNCTION"]},{"referenceNumber":78,"citation":{"id":"40440427","citationType":"journal article","authors":["Zhou L.","Chen Z.","Zou Y.","Zhang X.","Wang Z.","Zhu H.","Lin J.","Huang Z.","Zheng L.","Chen J.","Xie M.","Zhang M.","Zhang R.","Zhu M.","Wang Z.","Zhou H.","Gao S.","Yin Y.","Wu Y.","Kang T."],"citationCrossReferences":[{"database":"PubMed","id":"40440427"},{"database":"DOI","id":"10.1126/science.adq7408"}],"title":"ASB7 is a negative regulator of H3K9me3 homeostasis.","publicationDate":"2025","journal":"Science","firstPage":"309","lastPage":"316","volume":"389"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":79,"citation":{"id":"41100585","citationType":"journal article","authors":["Cushing V.I.","McGeoch A.J.S.","Williams S.L.","Roumeliotis T.I.","Feng J.","Dan L.M.","Choudhary J.S.","Davey N.E.","Greber B.J."],"citationCrossReferences":[{"database":"PubMed","id":"41100585"},{"database":"DOI","id":"10.1126/science.adw0053"}],"title":"Structural basis of T-loop-independent recognition and activation of CDKs by the CDK-activating kinase.","publicationDate":"2025","journal":"Science","firstPage":"911","lastPage":"917","volume":"390"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY","FUNCTION","ACTIVITY REGULATION","PHOSPHORYLATION AT THR-161"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"9SKQ"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X05360","properties":[{"key":"ProteinId","value":"CAA28963.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Y00272","properties":[{"key":"ProteinId","value":"CAA68376.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D88357","properties":[{"key":"ProteinId","value":"BAA26001.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291939","properties":[{"key":"ProteinId","value":"BAF84628.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT007004","properties":[{"key":"ProteinId","value":"AAP35650.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF512554","properties":[{"key":"ProteinId","value":"AAM34793.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022390","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471083","properties":[{"key":"ProteinId","value":"EAW54204.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC014563","properties":[{"key":"ProteinId","value":"AAH14563.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS44408.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P06493-1"},{"database":"CCDS","id":"CCDS7260.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P06493-2"},{"database":"PIR","id":"A29539","properties":[{"key":"EntryName","value":"A29539"}]},{"database":"RefSeq","id":"NP_001307847.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001320918.1"}],"isoformId":"P06493-1"},{"database":"RefSeq","id":"NP_001777.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001786.5"}],"isoformId":"P06493-1"},{"database":"RefSeq","id":"NP_203698.1","properties":[{"key":"NucleotideSequenceId","value":"NM_033379.5"}],"isoformId":"P06493-2"},{"database":"RefSeq","id":"XP_005270360.1","properties":[{"key":"NucleotideSequenceId","value":"XM_005270303.4"}],"isoformId":"P06493-1"},{"database":"RefSeq","id":"XP_054223227.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054367252.1"}],"isoformId":"P06493-1"},{"database":"PDB","id":"11GY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=1-297"}]},{"database":"PDB","id":"4Y72","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-297"}]},{"database":"PDB","id":"4YC3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=1-297"}]},{"database":"PDB","id":"4YC6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/C/E/G=1-297"}]},{"database":"PDB","id":"5HQ0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-297"}]},{"database":"PDB","id":"5LQF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.06 A"},{"key":"Chains","value":"A/D=1-297"}]},{"database":"PDB","id":"6GU2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-297"}]},{"database":"PDB","id":"6GU3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"A=1-297"}]},{"database":"PDB","id":"6GU4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.73 A"},{"key":"Chains","value":"A=1-297"}]},{"database":"PDB","id":"6GU6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.33 A"},{"key":"Chains","value":"A=1-297"}]},{"database":"PDB","id":"6GU7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"A/C/E/G=1-297"}]},{"database":"PDB","id":"6TWN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.28 A"},{"key":"Chains","value":"C/D=207-223"}]},{"database":"PDB","id":"7NJ0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"B=1-297"}]},{"database":"PDB","id":"9SKQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A=1-297"}]},{"database":"AlphaFoldDB","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12368","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54971","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107420","properties":[{"key":"Interactions","value":"613"}]},{"database":"ComplexPortal","id":"CPX-2003","properties":[{"key":"EntryName","value":"Cyclin A1-CDK1 complex"}]},{"database":"ComplexPortal","id":"CPX-2004","properties":[{"key":"EntryName","value":"Cyclin A2-CDK1 complex"}]},{"database":"ComplexPortal","id":"CPX-2007","properties":[{"key":"EntryName","value":"Cyclin B1-CDK1 complex"}]},{"database":"ComplexPortal","id":"CPX-2008","properties":[{"key":"EntryName","value":"Cyclin B2-CDK1 complex"}]},{"database":"CORUM","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-35N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P06493","properties":[{"key":"Number of interactors","value":"2614"}]},{"database":"IntAct","id":"P06493","properties":[{"key":"Interactions","value":"236"}]},{"database":"NDEx","id":"IQUERY-CP-CDK1","properties":[{"key":"Evidences","value":"23 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000378699","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL308","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB07149","properties":[{"key":"GenericName","value":"(7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one"}]},{"database":"DrugBank","id":"DB07364","properties":[{"key":"GenericName","value":"6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE"}]},{"database":"DrugBank","id":"DB13035","properties":[{"key":"GenericName","value":"AG-24322"}]},{"database":"DrugBank","id":"DB04014","properties":[{"key":"GenericName","value":"Alsterpaullone"}]},{"database":"DrugBank","id":"DB03496","properties":[{"key":"GenericName","value":"Alvocidib"}]},{"database":"DrugBank","id":"DB21530","properties":[{"key":"GenericName","value":"Asnuciclib"}]},{"database":"DrugBank","id":"DB08142","properties":[{"key":"GenericName","value":"AT-7519"}]},{"database":"DrugBank","id":"DB16652","properties":[{"key":"GenericName","value":"Avotaciclib"}]},{"database":"DrugBank","id":"DB03777","properties":[{"key":"GenericName","value":"Bisindolylmaleimide I"}]},{"database":"DrugBank","id":"DB12021","properties":[{"key":"GenericName","value":"Dinaciclib"}]},{"database":"DrugBank","id":"DB12010","properties":[{"key":"GenericName","value":"Fostamatinib"}]},{"database":"DrugBank","id":"DB02950","properties":[{"key":"GenericName","value":"Hymenialdisine"}]},{"database":"DrugBank","id":"DB02052","properties":[{"key":"GenericName","value":"Indirubin-3'-monoxime"}]},{"database":"DrugBank","id":"DB02519","properties":[{"key":"GenericName","value":"Indirubin-5-sulphonate"}]},{"database":"DrugBank","id":"DB07664","properties":[{"key":"GenericName","value":"K-00546"}]},{"database":"DrugBank","id":"DB19676","properties":[{"key":"GenericName","value":"Laduviglusib"}]},{"database":"DrugBank","id":"DB05608","properties":[{"key":"GenericName","value":"MKC-1"}]},{"database":"DrugBank","id":"DB02116","properties":[{"key":"GenericName","value":"Olomoucine"}]},{"database":"DrugBank","id":"DB12686","properties":[{"key":"GenericName","value":"PHA-793887"}]},{"database":"DrugBank","id":"DB02733","properties":[{"key":"GenericName","value":"Purvalanol"}]},{"database":"DrugBank","id":"DB04751","properties":[{"key":"GenericName","value":"Purvalanol A"}]},{"database":"DrugBank","id":"DB08094","properties":[{"key":"GenericName","value":"RO-4584820"}]},{"database":"DrugBank","id":"DB12974","properties":[{"key":"GenericName","value":"Roniciclib"}]},{"database":"DrugBank","id":"DB06195","properties":[{"key":"GenericName","value":"Seliciclib"}]},{"database":"DrugBank","id":"DB03428","properties":[{"key":"GenericName","value":"SU9516"}]},{"database":"DrugCentral","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"1961","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.I.1.1.3","properties":[{"key":"FamilyName","value":"the nuclear pore complex (npc) family"}]},{"database":"GlyGen","id":"P06493","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CDK1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"334302921","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1040","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1041","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1042","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1200","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-3054","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5897","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5898","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-797","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-798","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-801","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000378699","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51905","properties":[{"key":"Description","value":"-"}],"isoformId":"P06493-1"},{"database":"ProteomicsDB","id":"51906","properties":[{"key":"Description","value":"-"}],"isoformId":"P06493-2"},{"database":"Pumba","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1134","properties":[{"key":"antibodies","value":"2958 antibodies from 53 providers"}]},{"database":"CPTC","id":"P06493","properties":[{"key":"antibodies","value":"1 antibody"}]},{"database":"DNASU","id":"983","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000316629.8","properties":[{"key":"ProteinId","value":"ENSP00000325970.4"},{"key":"GeneId","value":"ENSG00000170312.18"}],"isoformId":"P06493-2"},{"database":"Ensembl","id":"ENST00000373809.2","properties":[{"key":"ProteinId","value":"ENSP00000362915.2"},{"key":"GeneId","value":"ENSG00000170312.18"}],"isoformId":"P06493-2"},{"database":"Ensembl","id":"ENST00000395284.8","properties":[{"key":"ProteinId","value":"ENSP00000378699.3"},{"key":"GeneId","value":"ENSG00000170312.18"}],"isoformId":"P06493-1"},{"database":"Ensembl","id":"ENST00000856537.1","properties":[{"key":"ProteinId","value":"ENSP00000526596.1"},{"key":"GeneId","value":"ENSG00000170312.18"}],"isoformId":"P06493-1"},{"database":"Ensembl","id":"ENST00000925686.1","properties":[{"key":"ProteinId","value":"ENSP00000595745.1"},{"key":"GeneId","value":"ENSG00000170312.18"}],"isoformId":"P06493-1"},{"database":"Ensembl","id":"ENST00000925687.1","properties":[{"key":"ProteinId","value":"ENSP00000595746.1"},{"key":"GeneId","value":"ENSG00000170312.18"}],"isoformId":"P06493-1"},{"database":"GeneID","id":"983","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:983","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000395284.8","properties":[{"key":"ProteinId","value":"ENSP00000378699.3"},{"key":"RefSeqNucleotideId","value":"NM_001786.5"},{"key":"RefSeqProteinId","value":"NP_001777.1"}]},{"database":"UCSC","id":"uc001jld.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P06493-1"},{"database":"AGR","id":"HGNC:1722","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA99","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"983","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"983","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CDK1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1722","properties":[{"key":"GeneName","value":"CDK1"}]},{"database":"HPA","id":"ENSG00000170312","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (bone marrow, lymphoid tissue)"}]},{"database":"MIM","id":"116940","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000170312","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000170312","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0594","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000153335","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000288_181_6_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AACNHPY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1732493at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P06493","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.7.11.22","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-110056","properties":[{"key":"PathwayName","value":"MAPK3 (ERK1) activation"}]},{"database":"Reactome","id":"R-HSA-113507","properties":[{"key":"PathwayName","value":"E2F-enabled inhibition of pre-replication complex formation"}]},{"database":"Reactome","id":"R-HSA-1362300","properties":[{"key":"PathwayName","value":"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"}]},{"database":"Reactome","id":"R-HSA-162658","properties":[{"key":"PathwayName","value":"Golgi Cisternae Pericentriolar Stack Reorganization"}]},{"database":"Reactome","id":"R-HSA-174048","properties":[{"key":"PathwayName","value":"APC/C:Cdc20 mediated degradation of Cyclin B"}]},{"database":"Reactome","id":"R-HSA-174184","properties":[{"key":"PathwayName","value":"Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}]},{"database":"Reactome","id":"R-HSA-176408","properties":[{"key":"PathwayName","value":"Regulation of APC/C activators between G1/S and early anaphase"}]},{"database":"Reactome","id":"R-HSA-176412","properties":[{"key":"PathwayName","value":"Phosphorylation of the APC/C"}]},{"database":"Reactome","id":"R-HSA-176417","properties":[{"key":"PathwayName","value":"Phosphorylation of Emi1"}]},{"database":"Reactome","id":"R-HSA-2299718","properties":[{"key":"PathwayName","value":"Condensation of Prophase Chromosomes"}]},{"database":"Reactome","id":"R-HSA-2465910","properties":[{"key":"PathwayName","value":"MASTL Facilitates Mitotic Progression"}]},{"database":"Reactome","id":"R-HSA-2500257","properties":[{"key":"PathwayName","value":"Resolution of Sister Chromatid Cohesion"}]},{"database":"Reactome","id":"R-HSA-2514853","properties":[{"key":"PathwayName","value":"Condensation of Prometaphase Chromosomes"}]},{"database":"Reactome","id":"R-HSA-2565942","properties":[{"key":"PathwayName","value":"Regulation of PLK1 Activity at G2/M Transition"}]},{"database":"Reactome","id":"R-HSA-2980767","properties":[{"key":"PathwayName","value":"Activation of NIMA Kinases NEK9, NEK6, NEK7"}]},{"database":"Reactome","id":"R-HSA-2995383","properties":[{"key":"PathwayName","value":"Initiation of Nuclear Envelope (NE) Reformation"}]},{"database":"Reactome","id":"R-HSA-3301854","properties":[{"key":"PathwayName","value":"Nuclear Pore Complex (NPC) Disassembly"}]},{"database":"Reactome","id":"R-HSA-380259","properties":[{"key":"PathwayName","value":"Loss of Nlp from mitotic centrosomes"}]},{"database":"Reactome","id":"R-HSA-380270","properties":[{"key":"PathwayName","value":"Recruitment of mitotic centrosome proteins and complexes"}]},{"database":"Reactome","id":"R-HSA-380284","properties":[{"key":"PathwayName","value":"Loss of proteins required for interphase microtubule organization from the centrosome"}]},{"database":"Reactome","id":"R-HSA-380320","properties":[{"key":"PathwayName","value":"Recruitment of NuMA to mitotic centrosomes"}]},{"database":"Reactome","id":"R-HSA-4419969","properties":[{"key":"PathwayName","value":"Depolymerization of the Nuclear Lamina"}]},{"database":"Reactome","id":"R-HSA-5620912","properties":[{"key":"PathwayName","value":"Anchoring of the basal body to the plasma membrane"}]},{"database":"Reactome","id":"R-HSA-5687128","properties":[{"key":"PathwayName","value":"MAPK6/MAPK4 signaling"}]},{"database":"Reactome","id":"R-HSA-5689896","properties":[{"key":"PathwayName","value":"Ovarian tumor domain proteases"}]},{"database":"Reactome","id":"R-HSA-6804114","properties":[{"key":"PathwayName","value":"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"}]},{"database":"Reactome","id":"R-HSA-6804757","properties":[{"key":"PathwayName","value":"Regulation of TP53 Degradation"}]},{"database":"Reactome","id":"R-HSA-68875","properties":[{"key":"PathwayName","value":"Mitotic Prophase"}]},{"database":"Reactome","id":"R-HSA-69205","properties":[{"key":"PathwayName","value":"G1/S-Specific Transcription"}]},{"database":"Reactome","id":"R-HSA-69273","properties":[{"key":"PathwayName","value":"Cyclin A/B1/B2 associated events during G2/M transition"}]},{"database":"Reactome","id":"R-HSA-69478","properties":[{"key":"PathwayName","value":"G2/M DNA replication checkpoint"}]},{"database":"Reactome","id":"R-HSA-75035","properties":[{"key":"PathwayName","value":"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"}]},{"database":"Reactome","id":"R-HSA-8852276","properties":[{"key":"PathwayName","value":"The role of GTSE1 in G2/M progression after G2 checkpoint"}]},{"database":"Reactome","id":"R-HSA-8854518","properties":[{"key":"PathwayName","value":"AURKA Activation by TPX2"}]},{"database":"Reactome","id":"R-HSA-8878166","properties":[{"key":"PathwayName","value":"Transcriptional regulation by RUNX2"}]},{"database":"Reactome","id":"R-HSA-9833482","properties":[{"key":"PathwayName","value":"PKR-mediated signaling"}]},{"database":"SignaLink","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000170312","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"983","properties":[{"key":"hits","value":"864 hits in 1157 CRISPR screens"}]},{"database":"CD-CODE","id":"6A1B29D1","properties":[{"key":"EntryName","value":"A-bodies"}]},{"database":"CD-CODE","id":"6F24707C","properties":[{"key":"EntryName","value":"Cajal body"}]},{"database":"CD-CODE","id":"804901D1","properties":[{"key":"EntryName","value":"Nuclear speckle"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"ChiTaRS","id":"CDK1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P06493","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Cdk1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Cyclin-dependent_kinase_1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"983","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P06493","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P06493","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"RNAct","id":"P06493","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000170312","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 151 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P06493","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17488717"}]},{"database":"GO","id":"GO:0000781","properties":[{"key":"GoTerm","value":"C:chromosome, telomeric region"},{"key":"GoEvidenceType","value":"HDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19135898"}]},{"database":"GO","id":"GO:0097121","properties":[{"key":"GoTerm","value":"C:cyclin A1-CDK1 complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19592082"}]},{"database":"GO","id":"GO:0097122","properties":[{"key":"GoTerm","value":"C:cyclin A2-CDK1 complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0097125","properties":[{"key":"GoTerm","value":"C:cyclin B1-CDK1 complex"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24746669"}]},{"database":"GO","id":"GO:0000307","properties":[{"key":"GoTerm","value":"C:cyclin-dependent protein kinase holoenzyme complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15767402"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0030496","properties":[{"key":"GoTerm","value":"C:midbody"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11069302"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"19917720"}]},{"database":"GO","id":"GO:0072686","properties":[{"key":"GoTerm","value":"C:mitotic spindle"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17488717"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15767402"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16109376"}]},{"database":"GO","id":"GO:0005876","properties":[{"key":"GoTerm","value":"C:spindle microtubule"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11069302"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0030332","properties":[{"key":"GoTerm","value":"F:cyclin binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7739547"}]},{"database":"GO","id":"GO:0097472","properties":[{"key":"GoTerm","value":"F:cyclin-dependent protein kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0004693","properties":[{"key":"GoTerm","value":"F:cyclin-dependent protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11069302"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18477460"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19202191"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2188730"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2344612"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23601106"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30139873"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37788673"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"40440427"}]},{"database":"GO","id":"GO:0035173","properties":[{"key":"GoTerm","value":"F:histone kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21871177"}]},{"database":"GO","id":"GO:0016301","properties":[{"key":"GoTerm","value":"F:kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28575661"}]},{"database":"GO","id":"GO:0004672","properties":[{"key":"GoTerm","value":"F:protein kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23574715"}]},{"database":"GO","id":"GO:0106310","properties":[{"key":"GoTerm","value":"F:protein serine kinase activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19202191"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2188730"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23355470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2344612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26829474"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30704899"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21871177"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23509069"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25012651"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26829474"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28479321"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31279575"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31804178"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32491969"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34741373"}]},{"database":"GO","id":"GO:0008353","properties":[{"key":"GoTerm","value":"F:RNA polymerase II CTD heptapeptide repeat kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12721286"}]},{"database":"GO","id":"GO:0016477","properties":[{"key":"GoTerm","value":"P:cell migration"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"17200138"}]},{"database":"GO","id":"GO:0070301","properties":[{"key":"GoTerm","value":"P:cellular response to hydrogen peroxide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007098","properties":[{"key":"GoTerm","value":"P:centrosome cycle"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"19364923"}]},{"database":"GO","id":"GO:0030261","properties":[{"key":"GoTerm","value":"P:chromosome condensation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006974","properties":[{"key":"GoTerm","value":"P:DNA damage response"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19202191"}]},{"database":"GO","id":"GO:0006281","properties":[{"key":"GoTerm","value":"P:DNA repair"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21655336"}]},{"database":"GO","id":"GO:0006260","properties":[{"key":"GoTerm","value":"P:DNA replication"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21655336"}]},{"database":"GO","id":"GO:0030855","properties":[{"key":"GoTerm","value":"P:epithelial cell differentiation"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"21492153"}]},{"database":"GO","id":"GO:0070371","properties":[{"key":"GoTerm","value":"P:ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0000082","properties":[{"key":"GoTerm","value":"P:G1/S transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11687586"}]},{"database":"GO","id":"GO:0000086","properties":[{"key":"GoTerm","value":"P:G2/M transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2188730"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2344612"}]},{"database":"GO","id":"GO:0090166","properties":[{"key":"GoTerm","value":"P:Golgi disassembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21655336"}]},{"database":"GO","id":"GO:1902850","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization involved in mitosis"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10791892"}]},{"database":"GO","id":"GO:0007095","properties":[{"key":"GoTerm","value":"P:mitotic G2 DNA damage checkpoint signaling"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007077","properties":[{"key":"GoTerm","value":"P:mitotic nuclear membrane disassembly"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2188730"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11069302"}]},{"database":"GO","id":"GO:0031397","properties":[{"key":"GoTerm","value":"P:negative regulation of protein ubiquitination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"40440427"}]},{"database":"GO","id":"GO:0018107","properties":[{"key":"GoTerm","value":"P:peptidyl-threonine phosphorylation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27238018"}]},{"database":"GO","id":"GO:0060045","properties":[{"key":"GoTerm","value":"P:positive regulation of cardiac muscle cell proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045740","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA replication"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0010971","properties":[{"key":"GoTerm","value":"P:positive regulation of G2/M transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24746669"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1905448","properties":[{"key":"GoTerm","value":"P:positive regulation of mitochondrial ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24746669"}]},{"database":"GO","id":"GO:0062033","properties":[{"key":"GoTerm","value":"P:positive regulation of mitotic sister chromatid segregation"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26829474"}]},{"database":"GO","id":"GO:0042307","properties":[{"key":"GoTerm","value":"P:positive regulation of protein import into nucleus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1900182","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to nucleus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21871177"}]},{"database":"GO","id":"GO:0045880","properties":[{"key":"GoTerm","value":"P:positive regulation of smoothened signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31279575"}]},{"database":"GO","id":"GO:2000060","properties":[{"key":"GoTerm","value":"P:positive regulation of ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22411829"}]},{"database":"GO","id":"GO:0007344","properties":[{"key":"GoTerm","value":"P:pronuclear fusion"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21535261"}]},{"database":"GO","id":"GO:0016579","properties":[{"key":"GoTerm","value":"P:protein deubiquitination"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0034501","properties":[{"key":"GoTerm","value":"P:protein localization to kinetochore"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18195732"}]},{"database":"GO","id":"GO:0065003","properties":[{"key":"GoTerm","value":"P:protein-containing complex assembly"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1902423","properties":[{"key":"GoTerm","value":"P:regulation of attachment of mitotic spindle microtubules to kinetochore"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28479321"}]},{"database":"GO","id":"GO:0042752","properties":[{"key":"GoTerm","value":"P:regulation of circadian rhythm"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27238018"}]},{"database":"GO","id":"GO:0045995","properties":[{"key":"GoTerm","value":"P:regulation of embryonic development"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21535261"}]},{"database":"GO","id":"GO:0120261","properties":[{"key":"GoTerm","value":"P:regulation of heterochromatin organization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"40440427"}]},{"database":"GO","id":"GO:0014038","properties":[{"key":"GoTerm","value":"P:regulation of Schwann cell differentiation"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"17200138"}]},{"database":"GO","id":"GO:0014823","properties":[{"key":"GoTerm","value":"P:response to activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0014075","properties":[{"key":"GoTerm","value":"P:response to amine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048678","properties":[{"key":"GoTerm","value":"P:response to axon injury"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046686","properties":[{"key":"GoTerm","value":"P:response to cadmium ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046688","properties":[{"key":"GoTerm","value":"P:response to copper ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045471","properties":[{"key":"GoTerm","value":"P:response to ethanol"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009636","properties":[{"key":"GoTerm","value":"P:response to toxic substance"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0055015","properties":[{"key":"GoTerm","value":"P:ventricular cardiac muscle cell development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd07861","properties":[{"key":"EntryName","value":"STKc_CDK1_euk"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000231","properties":[{"key":"EntryName","value":"Cyclin-dependent kinase 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000027","properties":[{"key":"EntryName","value":"Putative Cyclin-dependent kinase 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050108","properties":[{"key":"EntryName","value":"CDK"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"PANTHER","id":"PTHR24056","properties":[{"key":"EntryName","value":"CELL DIVISION PROTEIN KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24056:SF334","properties":[{"key":"EntryName","value":"CYCLIN-DEPENDENT KINASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM","length":297,"molWeight":34095,"crc64":"942D79448EFE490A","md5":"C5F024DB8FDFC09C76E40635FC0AA6F1"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":3,"ACTIVITY REGULATION":1,"SUBUNIT":3,"INTERACTION":21,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":2,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Active site":1,"Binding site":2,"Modified residue":15,"Cross-link":4,"Alternative sequence":1,"Mutagenesis":2,"Helix":17,"Beta strand":11,"Turn":5},"uniParcId":"UPI0000035BE1"}}