{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P05704","secondaryAccessions":["P77448"],"uniProtkbId":"MCP3_ECOLI","entryAudit":{"firstPublicDate":"1988-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-11-01","entryVersion":192,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Methyl-accepting chemotaxis protein III"},"shortNames":[{"value":"MCP-III"}]},"alternativeNames":[{"fullName":{"value":"Ribose and galactose chemoreceptor protein"}}]},"genes":[{"geneName":{"value":"trg"},"orderedLocusNames":[{"value":"b1421"},{"value":"JW1417"}]}],"comments":[{"texts":[{"value":"Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-binding proteins"}],"commentType":"FUNCTION"},{"texts":[{"value":"Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P05704","intActId":"EBI-557436"},"interactantTwo":{"uniProtKBAccession":"P45543","geneName":"frlD","intActId":"EBI-562037"},"numberOfExperiments":5,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Found predominantly at cell poles"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15919996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22380631"}],"value":"Cell inner membrane","id":"SL-0037"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15919996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22380631"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the methyl-accepting chemotaxis (MCP) protein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":546,"modifier":"EXACT"}},"description":"Methyl-accepting chemotaxis protein III","featureId":"PRO_0000110540"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":546,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"HAMP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00102"}]},{"type":"Domain","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"Methyl-accepting transducer","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00284"}]},{"type":"Modified residue","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Glu)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6300110"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6374654"}]},{"type":"Modified residue","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Gln)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6300110"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6374654"}]},{"type":"Modified residue","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Gln)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6300110"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6374654"}]},{"type":"Modified residue","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Glu)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6300110"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6374654"}]},{"type":"Modified residue","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"Glutamate methyl ester (Glu)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6300110"}]}],"keywords":[{"id":"KW-0997","category":"Cellular component","name":"Cell inner membrane"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"6374654","citationType":"journal article","authors":["Bollinger J.","Park C.","Harayama S.","Hazelbauer G.L."],"citationCrossReferences":[{"database":"PubMed","id":"6374654"},{"database":"DOI","id":"10.1073/pnas.81.11.3287"}],"title":"Structure of the Trg protein: homologies with and differences from other sensory transducers of Escherichia coli.","publicationDate":"1984","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"3287","lastPage":"3291","volume":"81"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"CI-DLS2R56NTI2GJ","citationType":"submission","authors":["Hazelbauer G.L."],"publicationDate":"MAR-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":3,"citation":{"id":"9097039","citationType":"journal article","authors":["Aiba H.","Baba T.","Fujita K.","Hayashi K.","Inada T.","Isono K.","Itoh T.","Kasai H.","Kashimoto K.","Kimura S.","Kitakawa M.","Kitagawa M.","Makino K.","Miki T.","Mizobuchi K.","Mori H.","Mori T.","Motomura K.","Nakade S.","Nakamura Y.","Nashimoto H.","Nishio Y.","Oshima T.","Saito N.","Sampei G.","Seki Y.","Sivasundaram S.","Tagami H.","Takeda J.","Takemoto K.","Takeuchi Y.","Wada C.","Yamamoto Y.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"9097039"},{"database":"DOI","id":"10.1093/dnares/3.6.363"}],"title":"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.","publicationDate":"1996","journal":"DNA Res.","firstPage":"363","lastPage":"377","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"6300110","citationType":"journal article","authors":["Kehry M.R.","Engstrom P.","Dahlquist F.W.","Hazelbauer G.L."],"citationCrossReferences":[{"database":"PubMed","id":"6300110"},{"database":"DOI","id":"10.1016/s0021-9258(18)32536-5"}],"title":"Multiple covalent modifications of Trg, a sensory transducer of Escherichia coli.","publicationDate":"1983","journal":"J. Biol. Chem.","firstPage":"5050","lastPage":"5055","volume":"258"},"referencePositions":["DEAMIDATION AT GLN-312 AND GLN-319","METHYLATION AT GLU-305; GLN-312; GLN-319; GLU-501 AND GLU-510"]},{"referenceNumber":7,"citation":{"id":"15919996","citationType":"journal article","authors":["Daley D.O.","Rapp M.","Granseth E.","Melen K.","Drew D.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"15919996"},{"database":"DOI","id":"10.1126/science.1109730"}],"title":"Global topology analysis of the Escherichia coli inner membrane proteome.","publicationDate":"2005","journal":"Science","firstPage":"1321","lastPage":"1323","volume":"308"},"referencePositions":["SUBCELLULAR LOCATION"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":8,"citation":{"id":"22380631","citationType":"journal article","authors":["Li G.","Young K.D."],"citationCrossReferences":[{"database":"PubMed","id":"22380631"},{"database":"DOI","id":"10.1111/j.1365-2958.2012.08021.x"}],"title":"Isolation and identification of new inner membrane-associated proteins that localize to cell poles in Escherichia coli.","publicationDate":"2012","journal":"Mol. Microbiol.","firstPage":"276","lastPage":"295","volume":"84"},"referencePositions":["SUBCELLULAR LOCATION"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"K02073","properties":[{"key":"ProteinId","value":"AAA81329.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC74503.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAA15044.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"H64893","properties":[{"key":"EntryName","value":"QREC3M"}]},{"database":"RefSeq","id":"NP_415938.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_001098559.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P05704","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P05704","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4261384","properties":[{"key":"Interactions","value":"399"}]},{"database":"BioGRID","id":"850357","properties":[{"key":"Interactions","value":"1"}]},{"database":"DIP","id":"DIP-11027N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P05704","properties":[{"key":"Number of interactors","value":"243"}]},{"database":"IntAct","id":"P05704","properties":[{"key":"Interactions","value":"5"}]},{"database":"STRING","id":"511145.b1421","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b1421","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC74503","properties":[{"key":"ProteinId","value":"AAC74503"},{"key":"GeneId","value":"b1421"}]},{"database":"GeneID","id":"945995","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW1417","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b1421","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_08275","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.849","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB1011","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG0840","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_000445_107_16_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P05704","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DLQTMQH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6532575at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P05704","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:TRG-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P05704","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P05704","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0098561","properties":[{"key":"GoTerm","value":"C:methyl accepting chemotaxis protein complex"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15916610"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15919996"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17309111"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7007323"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15916610"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"370826"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8876172"}]},{"database":"GO","id":"GO:0006935","properties":[{"key":"GoTerm","value":"P:chemotaxis"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"370826"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"370826"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8876172"}]},{"database":"CDD","id":"cd06225","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd11386","properties":[{"key":"EntryName","value":"MCP_signal"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd19407","properties":[{"key":"EntryName","value":"Tar_Tsr_sensor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.30:FF:000003","properties":[{"key":"EntryName","value":"Methyl-accepting chemotaxis protein III"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.950:FF:000001","properties":[{"key":"EntryName","value":"Methyl-accepting chemotaxis sensory transducer"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.30","properties":[{"key":"EntryName","value":"Aspartate receptor, ligand-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.950","properties":[{"key":"EntryName","value":"Methyl-accepting chemotaxis protein"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR035440","properties":[{"key":"EntryName","value":"4HB_MCP_dom_sf"}]},{"database":"InterPro","id":"IPR004090","properties":[{"key":"EntryName","value":"Chemotax_Me-accpt_rcpt"}]},{"database":"InterPro","id":"IPR004091","properties":[{"key":"EntryName","value":"Chemotax_Me-accpt_rcpt_Me-site"}]},{"database":"InterPro","id":"IPR003660","properties":[{"key":"EntryName","value":"HAMP_dom"}]},{"database":"InterPro","id":"IPR004089","properties":[{"key":"EntryName","value":"MCPsignal_dom"}]},{"database":"InterPro","id":"IPR003122","properties":[{"key":"EntryName","value":"Tar_rcpt_lig-bd"}]},{"database":"PANTHER","id":"PTHR43531:SF5","properties":[{"key":"EntryName","value":"METHYL-ACCEPTING CHEMOTAXIS PROTEIN III"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43531","properties":[{"key":"EntryName","value":"PROTEIN ICFG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00672","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00015","properties":[{"key":"EntryName","value":"MCPsignal"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02203","properties":[{"key":"EntryName","value":"TarH"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00260","properties":[{"key":"EntryName","value":"CHEMTRNSDUCR"}]},{"database":"SMART","id":"SM00304","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00283","properties":[{"key":"EntryName","value":"MA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00319","properties":[{"key":"EntryName","value":"TarH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47170","properties":[{"key":"EntryName","value":"Aspartate receptor, ligand-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58104","properties":[{"key":"EntryName","value":"Methyl-accepting chemotaxis protein (MCP) signaling domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00538","properties":[{"key":"EntryName","value":"CHEMOTAXIS_TRANSDUC_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50111","properties":[{"key":"EntryName","value":"CHEMOTAXIS_TRANSDUC_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50885","properties":[{"key":"EntryName","value":"HAMP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNTTPSQRLGFLHHIRLVPLFACILGGILVLFALSSALAGYFLWQADRDQRDVTAEIEIRTGLANSSDFLRSARINMIQAGAASRIAEMEAMKRNIAQAESEIKQSQQGYRAYQNRPVKTPADEALDTELNQRFQAYITGMQPMLKYAKNGMFEAIINHESEQIRPLDNAYTDILNKAVKIRSTRANQLAELAHQRTRLGGMFMIGAFVLALVMTLITFMVLRRIVIRPLQHAAQRIEKIASGDLTMNDEPAGRNEIGRLSRHLQQMQHSLGMTVGTVRQGAEEIYRGTSEISAGNADLSSRTEEQAAAIEQTAASMEQLTATVKQNADNAHHASKLAQEASIKASDGGQTVSGVVKTMGAISTSSKKISEITAVINSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRTLASRSAQAAKEIEGLISESVRLIDLGSDEVATAGKTMSTIVDAVASVTHIMQEIAAASDEQSRGITQVSQAISEMDKVTQQNASLVEEASAAAVSLEEQAARLTEAVDVFRLHKHSVSAEPRGAGEPVSFATV","length":546,"molWeight":58899,"crc64":"FDB40374C0E83E7B","md5":"DF2F866EC0F8D7DFF30EFA9AC431B14C"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":3,"Transmembrane":2,"Domain":2,"Modified residue":5},"uniParcId":"UPI000012EDA5"}}