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Catalyzes the second reaction in the inducible quinic acid catabolic pathway by converting 3-dehydroquinate into 3-dehydroshikimate (PubMed:143663). The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-dehydroquinate = 3-dehydroshikimate + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21096"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16630"},{"database":"ChEBI","id":"CHEBI:32364"}],"ecNumber":"4.2.1.10","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"126226"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8257437"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21097"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"126226"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8257437"}]}]},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":450.0,"unit":"uM","substrate":"quinate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8257437"}]},{"constant":1.7,"unit":"mM","substrate":"shikimate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8257437"}]},{"constant":150.0,"unit":"uM","substrate":"NAD(+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8257437"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"126226"}],"value":"Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}],"value":"Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12477937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"144915"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17597928"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19236936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6458044"}],"value":"Expression is induced in the presence of quinic acid (PubMed:144915, PubMed:6458044). The quinic acid (qa) gene cluster is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein that blocks the qa-1F activator, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source such as glucose (PubMed:12477937, PubMed:17597928, PubMed:19236936, PubMed:6458044)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}],"value":"Belongs to the type-II 3-dehydroquinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Catabolic 3-dehydroquinase","featureId":"PRO_0000159948"},{"type":"Active site","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}]},{"type":"Active site","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}]},{"type":"Binding site","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}],"ligand":{"name":"substrate"}},{"type":"Site","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03136"}]},{"type":"Sequence conflict","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"in Ref. 3; CAA24237","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"IYGST","alternativeSequences":["STAQS"]}}],"keywords":[{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0672","category":"Biological process","name":"Quinate metabolism"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"2525625","citationType":"journal article","authors":["Geever R.F.","Huiet L.","Baum J.A.","Tyler B.M.","Patel V.B.","Rutledge B.J.","Case M.E.","Giles N.H."],"citationCrossReferences":[{"database":"PubMed","id":"2525625"},{"database":"DOI","id":"10.1016/0022-2836(89)90438-5"}],"title":"DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa.","publicationDate":"1989","journal":"J. 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