{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P04637","secondaryAccessions":["Q15086","Q15087","Q15088","Q16535","Q16807","Q16808","Q16809","Q16810","Q16811","Q16848","Q2XN98","Q3LRW1","Q3LRW2","Q3LRW3","Q3LRW4","Q3LRW5","Q86UG1","Q8J016","Q99659","Q9BTM4","Q9HAQ8","Q9NP68","Q9NPJ2","Q9NZD0","Q9UBI2","Q9UQ61"],"uniProtkbId":"P53_HUMAN","entryAudit":{"firstPublicDate":"1987-08-13","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2009-11-24","entryVersion":314,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cellular tumor antigen p53"}},"alternativeNames":[{"fullName":{"value":"Antigen NY-CO-13"}},{"fullName":{"value":"Phosphoprotein p53"}},{"fullName":{"value":"Tumor suppressor p53"}}]},"genes":[{"geneName":{"value":"TP53"},"synonyms":[{"value":"P53"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11025664"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12524540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15186775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17189187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17317671"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17349958"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19556538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20673990"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22726440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24051492"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24652652"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35618207"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36634798"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9840937"}],"value":"Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492)"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14534297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16793544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17015838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18650397"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19515728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20142040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20364130"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14534297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16793544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17015838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18650397"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19515728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20142040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20364130"}],"value":"Binds 1 zinc ion per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02340"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10361"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12524540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12750254"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12851404"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14534297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702041"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053879"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15109303"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15136035"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15186775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15687255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15855171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16219768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16322561"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16376338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16377624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16402859"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16474402"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16793544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16845383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17015838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17108107"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17121812"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17145718"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17170702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17245430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17317671"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17332504"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17591690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17719541"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17904127"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17954561"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17967874"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18585004"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18650397"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18690848"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18996393"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19509332"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19515728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19536131"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19556538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19837670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19880522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20096117"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20124405"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20142040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20228809"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20364130"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20385133"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20660729"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20870725"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21317932"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21952639"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22214662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22522597"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22726440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22914926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22945289"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23431171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23752197"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24625977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25168243"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25422469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25732823"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26868148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27323408"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29681526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32442400"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33591310"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34404770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35122041"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8875926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8875929"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9840937"}],"value":"Forms homodimers and homotetramers (PubMed:19011621). Binds DNA as a homotetramer (PubMed:36108750). Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity). Interacts with ARMC10, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53 (PubMed:10570149, PubMed:19880522, PubMed:22914926, PubMed:8875929). Interacts with PDCD5; the interaction is direct and prevents the interaction between TP53 and MDM2, thereby stabilizing TP53 (PubMed:22914926). Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest. Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and COP1. Interacts with CCAR2 (via N-terminus). Interacts with MORC3 (PubMed:17332504). Interacts (via C-terminus) with POU4F2 isoform 1 (via C-terminus) (PubMed:17145718). Interacts (via oligomerization region) with NOP53; the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of TP53 (PubMed:22522597). Interacts with AFG1L; mediates mitochondrial translocation of TP53 (PubMed:27323408). Interacts with UBD (PubMed:25422469). Interacts with TAF6 isoform 1 and isoform 4 (PubMed:20096117). Interacts with C10orf90/FATS; the interaction inhibits binding of TP53 and MDM2 (By similarity). Interacts with NUPR1; interaction is stress-dependent (PubMed:18690848). Forms a complex with EP300 and NUPR1; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Interacts with PRMT5 in response to DNA damage; the interaction is TTC5/STRAP dependent (PubMed:19011621). Interacts with PPP1R13L (via SH3 domain and ANK repeats); the interaction inhibits pro-apoptotic activity of p53/TP53 (PubMed:12524540). Interacts with PPP1R13B/ASPP1 and TP53BP2/ASPP2; the interactions promotes pro-apoptotic activity (PubMed:12524540). When phosphorylated at Ser-15, interacts with DDX3X and gamma-tubulin (PubMed:28842590). Interacts with KAT7/HBO1; leading to inhibit histone acetyltransferase activity of KAT7/HBO1 (PubMed:17954561). Interacts (via N-terminus) with E3 ubiquitin-protein ligase MUL1; the interaction results in ubiquitination of cytoplasmic TP53 at Lys-24 and subsequent proteasomal degradation (PubMed:21597459). Interacts with S100A4; this interaction promotes TP53 degradation (PubMed:23752197, PubMed:32442400). Interacts with BANP (By similarity). Interacts with TTC5/STRAP; the interaction may result in increased mitochondrial-dependent apoptosis (PubMed:25168243). Interacts with NQO1; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255). Interacts with DAZAP2 at TP53 target gene promoters; the interaction is triggered by DNA damage and leads to modulation of the expression of a subset of TP53 target genes, reducing DNA damage-induced cell death by limiting the expression of cell death-mediating TP53 target genes (PubMed:33591310). Interacts (via N-terminus) with ZNF768 (via zinc-finger domains); interaction might be facilitated by TP53 oligomerization state (PubMed:34404770). Forms a ternary complex with ALDOB and G6PD; this interaction is direct. ALDOB stabilizes the complex inhibiting G6PD activity and keeping oxidative pentose phosphate metabolism in check. Interacts with MORN3; the interactions mediate post-transcriptional modifications of TP53 by MDM2 and SIRT1 (PubMed:29681526). Interacts with HSPA9/MOT-2; the interaction promotes the degradation of TP53 (PubMed:24625977). Interacts with FBXO22; this interaction promotes TP53 proteasomal degradation (PubMed:26868148)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2175676"}],"value":"(Microbial infection) Interacts with cancer-associated/HPV E6 viral proteins leading to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19776115"}],"value":"(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL123"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25772236"}],"value":"(Microbial infection) Interacts (via N-terminus) with human adenovirus 5 E1B-55K protein; this interaction leads to the inhibition of TP53 function and/or its degradation"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34523970"}],"value":"(Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus/HHV-8 protein ORF45; this interaction results in the cytoplasmic localization of TP53 thereby decreasing its transcriptional activity"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P00519","geneName":"ABL1","intActId":"EBI-375543"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q13155","geneName":"AIMP2","intActId":"EBI-745226"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O95376","geneName":"ARIH2","intActId":"EBI-711158"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P49407","geneName":"ARRB1","intActId":"EBI-743313"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9UBL3","geneName":"ASH2L","intActId":"EBI-540797"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O95352-2","geneName":"ATG7","intActId":"EBI-15980880"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O15169","geneName":"AXIN1","intActId":"EBI-710484"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8N9N5","geneName":"BANP","intActId":"EBI-744695"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P10415","geneName":"BCL2","intActId":"EBI-77694"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q07817-1","geneName":"BCL2L1","intActId":"EBI-287195"},"numberOfExperiments":26,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O14503","geneName":"BHLHE40","intActId":"EBI-711810"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P15056","geneName":"BRAF","intActId":"EBI-365980"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P51587","geneName":"BRCA2","intActId":"EBI-79792"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9NPI1","geneName":"BRD7","intActId":"EBI-711221"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9BX70","geneName":"BTBD2","intActId":"EBI-710091"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9Y297","geneName":"BTRC","intActId":"EBI-307461"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P55212","geneName":"CASP6","intActId":"EBI-718729"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9BWC9","geneName":"CCDC106","intActId":"EBI-711501"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P48643","geneName":"CCT5","intActId":"EBI-355710"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P38936","geneName":"CDKN1A","intActId":"EBI-375077"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P17676","geneName":"CEBPB","intActId":"EBI-969696"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O14757","geneName":"CHEK1","intActId":"EBI-974488"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q92793","geneName":"CREBBP","intActId":"EBI-81215"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P55060","geneName":"CSE1L","intActId":"EBI-286709"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q14999","geneName":"CUL7","intActId":"EBI-308606"},"numberOfExperiments":19,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8IWT3","geneName":"CUL9","intActId":"EBI-311123"},"numberOfExperiments":16,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9P0U4","geneName":"CXXC1","intActId":"EBI-949911"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9UER7","geneName":"DAXX","intActId":"EBI-77321"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q92841","geneName":"DDX17","intActId":"EBI-746012"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P17844","geneName":"DDX5","intActId":"EBI-351962"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9NRR4","geneName":"DROSHA","intActId":"EBI-528367"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9BV47","geneName":"DUSP26","intActId":"EBI-2924519"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O14641","geneName":"DVL2","intActId":"EBI-740850"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q09472","geneName":"EP300","intActId":"EBI-447295"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P15036","geneName":"ETS2","intActId":"EBI-1646991"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q86XK2","geneName":"FBXO11","intActId":"EBI-1047804"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P21333-2","geneName":"FLNA","intActId":"EBI-9641086"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P51114","geneName":"FXR1","intActId":"EBI-713291"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P49841","geneName":"GSK3B","intActId":"EBI-373586"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P32780","geneName":"GTF2H1","intActId":"EBI-715539"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q13547","geneName":"HDAC1","intActId":"EBI-301834"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q86Z02","geneName":"HIPK1","intActId":"EBI-692891"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P09429","geneName":"HMGB1","intActId":"EBI-389432"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P41235","geneName":"HNF4A","intActId":"EBI-1049011"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P61978","geneName":"HNRNPK","intActId":"EBI-304185"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P61978-2","geneName":"HNRNPK","intActId":"EBI-7060731"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P38646","geneName":"HSPA9","intActId":"EBI-354932"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P04792","geneName":"HSPB1","intActId":"EBI-352682"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":19,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q7Z6Z7","geneName":"HUWE1","intActId":"EBI-625934"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q16666-2","geneName":"IFI16","intActId":"EBI-6273540"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O14920","geneName":"IKBKB","intActId":"EBI-81266"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9UHH9","geneName":"IP6K2","intActId":"EBI-747509"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q6NYC1","geneName":"JMJD6","intActId":"EBI-8464037"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q92993","geneName":"KAT5","intActId":"EBI-399080"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9H7Z6","geneName":"KAT8","intActId":"EBI-896414"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O60341-1","geneName":"KDM1A","intActId":"EBI-15599570"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8IZD2","geneName":"KMT2E","intActId":"EBI-2689959"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P13473-2","geneName":"LAMP2","intActId":"EBI-21591415"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P43356","geneName":"MAGEA2B","intActId":"EBI-5650739"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q96M61","geneName":"MAGEB18","intActId":"EBI-741835"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9UBF1","geneName":"MAGEC2","intActId":"EBI-5651487"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P46821","geneName":"MAP1B","intActId":"EBI-764611"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q15759","geneName":"MAPK11","intActId":"EBI-298304"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8IW41","geneName":"MAPKAPK5","intActId":"EBI-1201460"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q00987","geneName":"MDM2","intActId":"EBI-389668"},"numberOfExperiments":117,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O15151","geneName":"MDM4","intActId":"EBI-398437"},"numberOfExperiments":27,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9UHC7","geneName":"MKRN1","intActId":"EBI-373524"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P04731","geneName":"MT1A","intActId":"EBI-8045030"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P19338","geneName":"NCL","intActId":"EBI-346967"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9Y618","geneName":"NCOR2","intActId":"EBI-80830"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q99608","geneName":"NDN","intActId":"EBI-718177"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P23511","geneName":"NFYA","intActId":"EBI-389739"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P25208","geneName":"NFYB","intActId":"EBI-389728"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9Y3T9","geneName":"NOC2L","intActId":"EBI-751547"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O60936","geneName":"NOL3","intActId":"EBI-740992"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P06748","geneName":"NPM1","intActId":"EBI-78579"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P06748-1","geneName":"NPM1","intActId":"EBI-354150"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q15466","geneName":"NR0B2","intActId":"EBI-3910729"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P22736","geneName":"NR4A1","intActId":"EBI-721550"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O43847","geneName":"NRDC","intActId":"EBI-2371631"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O60285","geneName":"NUAK1","intActId":"EBI-1046789"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P49757","geneName":"NUMB","intActId":"EBI-915016"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q96FW1","geneName":"OTUB1","intActId":"EBI-1058491"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8TEW0","geneName":"PARD3","intActId":"EBI-81968"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P09874","geneName":"PARP1","intActId":"EBI-355676"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q96KB5","geneName":"PBK","intActId":"EBI-536853"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q7Z412","geneName":"PEX26","intActId":"EBI-752057"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P35232","geneName":"PHB1","intActId":"EBI-354213"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O75925","geneName":"PIAS1","intActId":"EBI-629434"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8N2W9","geneName":"PIAS4","intActId":"EBI-473160"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q92569","geneName":"PIK3R3","intActId":"EBI-79893"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q13526","geneName":"PIN1","intActId":"EBI-714158"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P53350","geneName":"PLK1","intActId":"EBI-476768"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P29590","geneName":"PML","intActId":"EBI-295890"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"A0A6Q8PF08","geneName":"PMP22","intActId":"EBI-50433196"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P30405","geneName":"PPIF","intActId":"EBI-5544229"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P36873-1","geneName":"PPP1CC","intActId":"EBI-356289"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8WUF5","geneName":"PPP1R13L","intActId":"EBI-5550163"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P30153","geneName":"PPP2R1A","intActId":"EBI-302388"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q13362","geneName":"PPP2R5C","intActId":"EBI-1266156"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O43741","geneName":"PRKAB2","intActId":"EBI-1053424"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q05655","geneName":"PRKCD","intActId":"EBI-704279"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P61289","geneName":"PSME3","intActId":"EBI-355546"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q05397","geneName":"PTK2","intActId":"EBI-702142"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q06609","geneName":"RAD51","intActId":"EBI-297202"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q06330","geneName":"RBPJ","intActId":"EBI-632552"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q96PM5","geneName":"RCHY1","intActId":"EBI-947779"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q6PCD5","geneName":"RFWD3","intActId":"EBI-2129159"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q06587","geneName":"RING1","intActId":"EBI-752313"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P23396","geneName":"RPS3","intActId":"EBI-351193"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9Y265","geneName":"RUVBL1","intActId":"EBI-353675"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8N488","geneName":"RYBP","intActId":"EBI-752324"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P23297","geneName":"S100A1","intActId":"EBI-743686"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P31949","geneName":"S100A11","intActId":"EBI-701862"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P29034","geneName":"S100A2","intActId":"EBI-752230"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P33764","geneName":"S100A3","intActId":"EBI-1044747"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P26447","geneName":"S100A4","intActId":"EBI-717058"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P33763","geneName":"S100A5","intActId":"EBI-7211732"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P06703","geneName":"S100A6","intActId":"EBI-352877"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P04271","geneName":"S100B","intActId":"EBI-458391"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P25815","geneName":"S100P","intActId":"EBI-743700"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q15424","geneName":"SAFB","intActId":"EBI-348298"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8WTS6","geneName":"SETD7","intActId":"EBI-1268586"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P31947","geneName":"SFN","intActId":"EBI-476295"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q96ST3","geneName":"SIN3A","intActId":"EBI-347218"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q96EB6","geneName":"SIRT1","intActId":"EBI-1802965"},"numberOfExperiments":18,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q15796","geneName":"SMAD2","intActId":"EBI-1040141"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9NRG4","geneName":"SMYD2","intActId":"EBI-1055671"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O95863","geneName":"SNAI1","intActId":"EBI-1045459"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q06945","geneName":"SOX4","intActId":"EBI-6672525"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P08047","geneName":"SP1","intActId":"EBI-298336"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q12772","geneName":"SREBF2","intActId":"EBI-465059"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q96SB4","geneName":"SRPK1","intActId":"EBI-539478"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P31948","geneName":"STIP1","intActId":"EBI-1054052"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P63165","geneName":"SUMO1","intActId":"EBI-80140"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q86TM6","geneName":"SYVN1","intActId":"EBI-947849"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9HBM6","geneName":"TAF9B","intActId":"EBI-751601"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P20226","geneName":"TBP","intActId":"EBI-355371"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P15884","geneName":"TCF4","intActId":"EBI-533224"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q96GM8","geneName":"TOE1","intActId":"EBI-717460"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P04637","geneName":"TP53","intActId":"EBI-366083"},"numberOfExperiments":34,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q12888","geneName":"TP53BP1","intActId":"EBI-396540"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q12888-1","geneName":"TP53BP1","intActId":"EBI-8022649"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q13625","geneName":"TP53BP2","intActId":"EBI-77642"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9H3D4","geneName":"TP63","intActId":"EBI-2337775"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P13693","geneName":"TPT1","intActId":"EBI-1783169"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O15164","geneName":"TRIM24","intActId":"EBI-2130378"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q15672","geneName":"TWIST1","intActId":"EBI-1797287"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P0CG48","geneName":"UBC","intActId":"EBI-3390054"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P63279","geneName":"UBE2I","intActId":"EBI-80168"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q05086","geneName":"UBE3A","intActId":"EBI-954357"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P09936","geneName":"UCHL1","intActId":"EBI-714860"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q96PU4","geneName":"UHRF2","intActId":"EBI-625304"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9H9J4","geneName":"USP42","intActId":"EBI-2513638"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9H9J4-2","geneName":"USP42","intActId":"EBI-9118105"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q93009","geneName":"USP7","intActId":"EBI-302474"},"numberOfExperiments":19,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P11473","geneName":"VDR","intActId":"EBI-286357"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q99986","geneName":"VRK1","intActId":"EBI-1769146"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q14191","geneName":"WRN","intActId":"EBI-368417"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9NZC7","geneName":"WWOX","intActId":"EBI-4320739"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O14980","geneName":"XPO1","intActId":"EBI-355867"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P12956","geneName":"XRCC6","intActId":"EBI-353208"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P61981","geneName":"YWHAG","intActId":"EBI-359832"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P63104","geneName":"YWHAZ","intActId":"EBI-347088"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8TAQ5","geneName":"ZNF420","intActId":"EBI-3923307"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q7L7W2","intActId":"EBI-7210801"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P29066","geneName":"Arrb1","intActId":"EBI-4303019"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9ESJ1","geneName":"Cables1","intActId":"EBI-604411"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P45481","geneName":"Crebbp","intActId":"EBI-296306"},"numberOfExperiments":10,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P03126","geneName":"E6","intActId":"EBI-1177242"},"numberOfExperiments":5,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P06463","geneName":"E6","intActId":"EBI-1186926"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P02829","geneName":"HSP82","intActId":"EBI-8659"},"numberOfExperiments":8,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q08619","geneName":"Ifi205b","intActId":"EBI-8064290"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P89055","geneName":"NSP1","intActId":"EBI-9522973"},"numberOfExperiments":6,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q923E4","geneName":"Sirt1","intActId":"EBI-1802585"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8R5A0","geneName":"Smyd2","intActId":"EBI-15612527"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P32776","geneName":"TFB1","intActId":"EBI-19146"},"numberOfExperiments":7,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"O88898","geneName":"Tp63","intActId":"EBI-2338025"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P26687","geneName":"Twist1","intActId":"EBI-6123119"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q9PST7","geneName":"znf585b.S","intActId":"EBI-1782562"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P03070","intActId":"EBI-617698"},"numberOfExperiments":22,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"P26663","chainId":"PRO_0000037536","intActId":"EBI-6838571"},"numberOfExperiments":9,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637","intActId":"EBI-366083"},"interactantTwo":{"uniProtKBAccession":"Q8QW27","intActId":"EBI-6863726"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04637-1","intActId":"EBI-3895849"},"interactantTwo":{"uniProtKBAccession":"P17844","geneName":"DDX5","intActId":"EBI-351962"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04637-7","intActId":"EBI-3895873"},"interactantTwo":{"uniProtKBAccession":"P17844","geneName":"DDX5","intActId":"EBI-351962"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22726440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24625977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27323408"}],"value":"Recruited into PML bodies together with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440). Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). Competitive inhibition of TP53 interaction with HSPA9/MOT-2 by UBXN2A results in increased protein abundance and subsequent translocation of TP53 to the nucleus (PubMed:24625977)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17170702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19033443"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21597459"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22726440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22914926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24625977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26634371"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17170702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17591690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18206965"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21597459"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22914926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24625977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26634371"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11025664"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36108750"}],"value":"Nucleus, PML body","id":"SL-0465"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17170702"}],"value":"Endoplasmic reticulum","id":"SL-0095"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22726440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25168243"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27323408"}],"value":"Mitochondrion matrix","id":"SL-0170"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842590"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","note":{"texts":[{"value":"Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23752197"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","note":{"texts":[{"value":"Localized mainly in the nucleus with minor staining in the cytoplasm"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 3","note":{"texts":[{"value":"Localized in the nucleus in most cells but found in the cytoplasm in some cells"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 4","note":{"texts":[{"value":"Predominantly nuclear but translocates to the cytoplasm following cell stress"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 7","note":{"texts":[{"value":"Localized mainly in the nucleus with minor staining in the cytoplasm"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 8","note":{"texts":[{"value":"Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 9","subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative promoter usage","Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"p53"},{"value":"p53alpha"}],"isoformIds":["P04637-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"I9RET"},{"value":"p53beta"}],"isoformIds":["P04637-2"],"sequenceIds":["VSP_006535","VSP_006536"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"p53gamma"}],"isoformIds":["P04637-3"],"sequenceIds":["VSP_040560","VSP_040561"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"synonyms":[{"value":"Del40-p53"},{"value":"Del40-p53alpha"},{"value":"p47"}],"isoformIds":["P04637-4"],"sequenceIds":["VSP_040832"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"synonyms":[{"value":"Del40-p53beta"}],"isoformIds":["P04637-5"],"sequenceIds":["VSP_040832","VSP_006535","VSP_006536"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"value":"Del40-p53gamma"}],"isoformIds":["P04637-6"],"sequenceIds":["VSP_040832","VSP_040560","VSP_040561"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"synonyms":[{"value":"Del133-p53"},{"value":"Del133-p53alpha"}],"isoformIds":["P04637-7"],"sequenceIds":["VSP_040833"],"isoformSequenceStatus":"Described"},{"name":{"value":"8"},"synonyms":[{"value":"Del133-p53beta"}],"isoformIds":["P04637-8"],"sequenceIds":["VSP_040833","VSP_006535","VSP_006536"],"isoformSequenceStatus":"Described"},{"name":{"value":"9"},"synonyms":[{"value":"Del133-p53gamma"}],"isoformIds":["P04637-9"],"sequenceIds":["VSP_040833","VSP_040560","VSP_040561"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16131611"}],"value":"Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16131611"}],"value":"Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31953488"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35618207"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36108750"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36634798"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}],"value":"The N-terminal and C-terminal disordered regions undergo liquid-liquid phase separation (LLPS) following homotetramerization and activation (PubMed:31953488, PubMed:35618207, PubMed:36108750, PubMed:36634798, PubMed:38653238). Post-translational modifications, such as phosphorylation or lactylation affect the ability to undergo LLPS (PubMed:31953488, PubMed:35618207, PubMed:36634798, PubMed:38653238)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17467953"}],"value":"The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10656795"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15448695"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17189187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19854137"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20228809"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23431171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29474172"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29681526"}],"value":"Acetylation of Lys-382 by CREBBP enhances transcriptional activity (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171). Acetylation of Lys-382 by EP300 (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171). Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171). Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171, PubMed:29681526). Acetylation at Lys-381 increases stability (PubMed:29474172). Deacetylation at Lys-381 by SIRT6 decreases its stability, thereby regulating cell senescence (PubMed:29474172). Acetylated at Lys-120 by KAT5, KAT6A and KAT8; regulating its ability to induce proapoptotic program (PubMed:17189187, PubMed:19854137, PubMed:23431171)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}],"value":"Lactylation by AARS1 prevents ability to undergo liquid-liquid phase separation (LLPS), thereby inhibiting transcription factor activity"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10606744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10884347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10951572"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11239457"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11447225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11546806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11551930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11554766"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11740489"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11780126"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702041"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053879"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15866171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16377624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16704422"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1705009"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17108107"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17254968"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17349958"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17591690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17967874"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18022393"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20041275"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20124405"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21317932"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2141171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22214662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527692"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9372954"}],"value":"Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity). Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2 (PubMed:10951572, PubMed:31527692). Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was initially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage. Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (PubMed:28842590). Phosphorylation at Ser-392 regulates its ability to undergo liquid-liquid phase separation by increasing fluidity of TP53/p53 condensates (PubMed:35618207)"}],"commentType":"PTM"},{"texts":[{"value":"Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the AC form of PP2A"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8632915"}],"value":"May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02340"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10722742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17170702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18206965"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19033443"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19473992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19536131"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19556538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19837670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19880522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20096447"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20173098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21597459"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25591766"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25732823"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26868148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28807825"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29681526"}],"value":"Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation (PubMed:10722742, PubMed:12810724, PubMed:15340061, PubMed:17170702, PubMed:19880522, PubMed:29681526). Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:10722742, PubMed:12810724, PubMed:20173098). Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation (PubMed:19536131). Deubiquitinated by USP10, leading to its stabilization (PubMed:20096447). Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation (PubMed:19556538). Ubiquitination by TOPORS induces degradation (PubMed:19473992). Deubiquitination by USP7, leading to stabilization (PubMed:15053880). Isoform 4 is monoubiquitinated in an MDM2-independent manner (PubMed:15340061). Ubiquitinated by COP1, which leads to proteasomal degradation (PubMed:19837670). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (PubMed:25732823). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (PubMed:21597459). Deubiquitinated by USP3, leading to stabilization (PubMed:28807825). Ubiquitinated by MSL2, promoting its cytoplasmic localization (PubMed:19033443). Also ubiquitinated by the SCF(FBXO22)-KDMA4A complex; leading to proteasomal degradation (PubMed:26868148)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15525938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16415881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17108971"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17707234"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17805299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20118233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22864287"}],"value":"Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation (PubMed:15525938, PubMed:16415881). Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity (PubMed:17108971). Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370 (PubMed:17108971). Dimethylated at Lys-373 by EHMT1 and EHMT2 (PubMed:20118233). Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity (PubMed:17707234). Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20 (PubMed:22864287). Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (PubMed:17805299). Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (PubMed:19011621)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11124955"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22214662"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.37"}],"value":"Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"value":"TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Esophageal cancer","diseaseAccession":"DI-01537","acronym":"ESCR","description":"A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.","diseaseCrossReference":{"database":"MIM","id":"133239"}},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Li-Fraumeni syndrome","diseaseAccession":"DI-01904","acronym":"LFS","description":"An autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers.","diseaseCrossReference":{"database":"MIM","id":"151623"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10484981"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1565144"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1737852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1933902"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1978757"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2259385"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36108750"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887414"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8825920"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9452042"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Squamous cell carcinoma of the head and neck","diseaseAccession":"DI-01696","acronym":"HNSCC","description":"A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.","diseaseCrossReference":{"database":"MIM","id":"275355"}},"note":{"texts":[{"value":"The gene represented in this entry is involved in disease pathogenesis"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Lung cancer","diseaseAccession":"DI-02205","acronym":"LNCR","description":"A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.","diseaseCrossReference":{"database":"MIM","id":"211980"}},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Papilloma of choroid plexus","diseaseAccession":"DI-01346","acronym":"CPP","description":"A benign tumor of neuroectodermal origin that generally occurs in childhood, but has also been reported in adults. Although generally found within the ventricular system, choroid plexus papillomas can arise ectopically in the brain parenchyma or disseminate throughout the neuraxis. Patients present with signs and symptoms of increased intracranial pressure including headache, hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures.","diseaseCrossReference":{"database":"MIM","id":"260500"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12085209"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Adrenocortical carcinoma","diseaseAccession":"DI-02740","acronym":"ADCC","description":"A malignant neoplasm of the adrenal cortex and a rare childhood tumor. It occurs with increased frequency in patients with Beckwith-Wiedemann syndrome and Li-Fraumeni syndrome.","diseaseCrossReference":{"database":"MIM","id":"202300"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11481490"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Basal cell carcinoma 7","diseaseAccession":"DI-03503","acronym":"BCC7","description":"A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.","diseaseCrossReference":{"database":"MIM","id":"614740"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21946351"}]},"note":{"texts":[{"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Bone marrow failure syndrome 5","diseaseAccession":"DI-05371","acronym":"BMFS5","description":"A form of bone marrow failure syndrome, a heterogeneous group of life-threatening disorders characterized by hematopoietic defects in association with a range of variable extra-hematopoietic manifestations. BMFS5 is an autosomal dominant form characterized by infantile onset of severe red cell anemia requiring transfusion. Additional features include hypogammaglobulinemia, poor growth with microcephaly, developmental delay, and seizures.","diseaseCrossReference":{"database":"MIM","id":"618165"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30146126"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative promoter usage"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 7"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative promoter usage and alternative splicing"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 8"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative promoter usage and alternative splicing"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 9"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the p53 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02340"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11554766"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15701641"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15866171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16219768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17170702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17317671"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17591690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17954561"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18206965"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21597459"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22726440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25772236"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32144153"}],"value":"Interaction with BANP was reported to enhance phosphorylation on Ser-15 upon ultraviolet irradiation (PubMed:15701641). However, the publication has been retracted due to image duplication and manipulation. Interaction with BANP has been confirmed in mouse studies (By similarity). Phosphorylation at Ser-15 has been confirmed by other studies (PubMed:10570149, PubMed:11554766, PubMed:15866171, PubMed:16219768, PubMed:17317671, PubMed:17954561, PubMed:20959462, PubMed:25772236). Its nuclear and cytoplasmic localization has been confirmed by other studies (PubMed:15340061, PubMed:17170702, PubMed:17591690, PubMed:18206965, PubMed:19011621, PubMed:21597459, PubMed:22726440)"}],"commentType":"CAUTION"},{"commentType":"WEB RESOURCE","resourceName":"The TP53 Database","resourceUrl":"https://tp53.cancer.gov/","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/88/P53","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/P53","ftp":false,"note":"P53 entry"},{"commentType":"WEB RESOURCE","resourceName":"Protein Spotlight","resourceUrl":"https://www.proteinspotlight.org/back_issues/206/","ftp":false,"note":"On the right track - Issue 206 of August 2018"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Cellular tumor antigen p53","featureId":"PRO_0000185703"},{"type":"DNA binding","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16793544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18996393"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20364130"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Interaction with CCAR2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25732823"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Interaction with HRMT1L2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15186775"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Transcription activation (acidic)"},{"type":"Region","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31953488"}]},{"type":"Region","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Interaction with WWOX"},{"type":"Region","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"Interaction with HIPK1","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Required for interaction with ZNF385A","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17719541"}]},{"type":"Region","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Required for interaction with FBXO42","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19509332"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"Interaction with AXIN1","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Interaction with the 53BP2 SH3 domain"},{"type":"Region","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"Interaction with E4F1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10644996"}]},{"type":"Region","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Interaction with DNA"},{"type":"Region","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Interaction with CARM1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15186775"}]},{"type":"Region","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Interaction with HIPK2"},{"type":"Region","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Oligomerization"},{"type":"Region","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31953488"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36108750"}]},{"type":"Region","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Interaction with USP7"},{"type":"Region","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"Basic (repression of DNA-binding)"},{"type":"Region","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Interaction with MORN3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29681526"}]},{"type":"Motif","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"TADI"},{"type":"Motif","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"TADII"},{"type":"Motif","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Bipartite nuclear localization signal"},{"type":"Motif","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Nuclear export signal"},{"type":"Motif","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"[KR]-[STA]-K motif"},{"type":"Compositional bias","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14534297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16793544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17015838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18650397"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19515728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20142040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20364130"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14534297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16793544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17015838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18650397"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19515728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20142040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20364130"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14534297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16793544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17015838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18650397"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19515728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20142040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20364130"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14534297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16793544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17015838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18650397"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19515728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20142040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20364130"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Site","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16793544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18996393"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20364130"}]},{"type":"Modified residue","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"Phosphoserine; by HIPK4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18022393"}]},{"type":"Modified residue","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11554766"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15866171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17108107"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17591690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17967874"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21317932"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842590"}]},{"type":"Modified residue","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"Phosphothreonine; by CK1, VRK1 and VRK2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10606744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10951572"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16704422"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527692"}]},{"type":"Modified residue","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Phosphoserine; by CHEK2, CK1 and PLK3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11447225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11551930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20041275"}]},{"type":"Modified residue","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Phosphoserine; by CDK5 and CDK7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17591690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9372954"}]},{"type":"Modified residue","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Phosphoserine; by MAPKAPK5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17254968"}]},{"type":"Modified residue","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11740489"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11780126"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16377624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17349958"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17591690"}]},{"type":"Modified residue","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Phosphothreonine; by TAF1 and GRK5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053879"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20124405"}]},{"type":"Modified residue","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17189187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19854137"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23431171"}]},{"type":"Modified residue","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"N6-lactoyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}]},{"type":"Modified residue","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"N6-lactoyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}]},{"type":"Modified residue","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Phosphoserine; by AURKB","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"}]},{"type":"Modified residue","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Phosphoserine; by AURKB","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"}]},{"type":"Modified residue","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Phosphothreonine; by AURKB","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"}]},{"type":"Modified residue","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724314"}]},{"type":"Modified residue","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Phosphoserine; by AURKA, CDK1 and CDK2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10884347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702041"}]},{"type":"Modified residue","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02340"}]},{"type":"Modified residue","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Omega-N-methylarginine; by PRMT5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"}]},{"type":"Modified residue","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Symmetric dimethylarginine; by PRMT5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"}]},{"type":"Modified residue","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Symmetric dimethylarginine; by PRMT5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"}]},{"type":"Modified residue","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"N6,N6-dimethyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17108971"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22864287"}]},{"type":"Modified residue","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"N6-methyllysine; by SMYD2; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17108971"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22864287"}]},{"type":"Modified residue","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"N6-methyllysine; by SETD7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15525938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16415881"}]},{"type":"Modified residue","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20118233"}]},{"type":"Modified residue","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10656795"}]},{"type":"Modified residue","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29474172"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"N6,N6-dimethyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17707234"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20870725"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22864287"}]},{"type":"Modified residue","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10656795"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15448695"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20228809"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23431171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29681526"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"N6-methyllysine; by KMT5A; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17707234"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20870725"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22864287"}]},{"type":"Modified residue","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"Phosphoserine; by CK2, CDK2 and NUAK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10884347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11239457"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17108107"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21317932"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22214662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35618207"}]},{"type":"Cross-link","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21597459"}]},{"type":"Cross-link","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19536131"}]},{"type":"Cross-link","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19536131"}]},{"type":"Cross-link","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19033443"}]},{"type":"Cross-link","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19033443"}]},{"type":"Cross-link","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11124955"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22214662"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.37"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in isoform 7, isoform 8 and isoform 9","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16131611"}],"featureId":"VSP_040833","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"in isoform 4, isoform 5 and isoform 6","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_040832","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"in isoform 3, isoform 6 and isoform 9","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16131611"}],"featureId":"VSP_040560","alternativeSequence":{"originalSequence":"IRGRERFEMFRELNE","alternativeSequences":["MLLDLRWCYFLINSS"]}},{"type":"Alternative sequence","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"in isoform 2, isoform 5 and isoform 8","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16131611"}],"featureId":"VSP_006535","alternativeSequence":{"originalSequence":"IRGRERFEMF","alternativeSequences":["DQTSFQKENC"]}},{"type":"Alternative sequence","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"in isoform 2, isoform 5 and isoform 8","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16131611"}],"featureId":"VSP_006536","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"in isoform 3, isoform 6 and isoform 9","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16131611"}],"featureId":"VSP_040561","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; abolishes strongly phosphorylation","featureId":"VAR_044543","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; reduces interaction with ZNF385A","featureId":"VAR_044544","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs587782646","featureCrossReferences":[{"database":"dbSNP","id":"rs587782646"}],"featureId":"VAR_005851","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044545","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs535274413","featureCrossReferences":[{"database":"dbSNP","id":"rs535274413"}],"featureId":"VAR_044546","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs201382018","featureCrossReferences":[{"database":"dbSNP","id":"rs201382018"}],"featureId":"VAR_044547","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs201382018","featureCrossReferences":[{"database":"dbSNP","id":"rs201382018"}],"featureId":"VAR_044548","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044549","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044550","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044551","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044552","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044553","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047158","alternativeSequence":{"originalSequence":"NN","alternativeSequences":["KD"]}},{"type":"Natural variant","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs201753350","featureCrossReferences":[{"database":"dbSNP","id":"rs201753350"}],"featureId":"VAR_044554","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044555","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044556","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912661","featureCrossReferences":[{"database":"dbSNP","id":"rs121912661"}],"featureId":"VAR_005852","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs587781866","featureCrossReferences":[{"database":"dbSNP","id":"rs587781866"}],"featureId":"VAR_044557","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044558","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044559","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044560","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1353016807","featureCrossReferences":[{"database":"dbSNP","id":"rs1353016807"}],"featureId":"VAR_044561","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044562","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_005853","alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1060501190","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501190"}],"featureId":"VAR_044563","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044564","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044565","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044566","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044567","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876659630","featureCrossReferences":[{"database":"dbSNP","id":"rs876659630"}],"featureId":"VAR_044568","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044569","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"in dbSNP:rs1800371","featureCrossReferences":[{"database":"dbSNP","id":"rs1800371"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"}],"featureId":"VAR_014632","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044570","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780728","featureCrossReferences":[{"database":"dbSNP","id":"rs587780728"}],"featureId":"VAR_044571","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs587780728","featureCrossReferences":[{"database":"dbSNP","id":"rs587780728"}],"featureId":"VAR_044572","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044573","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044574","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005854","alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044575","alternativeSequence":{"originalSequence":"W","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1555526742","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526742"}],"featureId":"VAR_044576","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044577","alternativeSequence":{"originalSequence":"F","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044578","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044579","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044580","alternativeSequence":{"originalSequence":"P","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044581","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1237722021","featureCrossReferences":[{"database":"dbSNP","id":"rs1237722021"}],"featureId":"VAR_044582","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044583","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045783","alternativeSequence":{"originalSequence":"G","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044584","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044585","alternativeSequence":{"originalSequence":"P","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_005855","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1460793472","featureCrossReferences":[{"database":"dbSNP","id":"rs1460793472"}],"featureId":"VAR_044586","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044587","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044588","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs876658902","featureCrossReferences":[{"database":"dbSNP","id":"rs876658902"}],"featureId":"VAR_044589","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs372201428","featureCrossReferences":[{"database":"dbSNP","id":"rs372201428"}],"featureId":"VAR_044590","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1060501210","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501210"}],"featureId":"VAR_044591","alternativeSequence":{"originalSequence":"R","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1555526711","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526711"}],"featureId":"VAR_044592","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044593","alternativeSequence":{"originalSequence":"M","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044594","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044595","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044596","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044597","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044598","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044599","alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs756233241","featureCrossReferences":[{"database":"dbSNP","id":"rs756233241"}],"featureId":"VAR_044600","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044601","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs756233241","featureCrossReferences":[{"database":"dbSNP","id":"rs756233241"}],"featureId":"VAR_044602","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044603","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044604","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions; dbSNP:rs730882014","featureCrossReferences":[{"database":"dbSNP","id":"rs730882014"}],"featureId":"VAR_045784","alternativeSequence":{"originalSequence":"P","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045785","alternativeSequence":{"originalSequence":"P","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1042522","featureCrossReferences":[{"database":"dbSNP","id":"rs1042522"}],"featureId":"VAR_045786","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045787","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"in dbSNP:rs1042522","featureCrossReferences":[{"database":"dbSNP","id":"rs1042522"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16131611"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1999338"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.17"}],"featureId":"VAR_005856","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044605","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044606","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782423","featureCrossReferences":[{"database":"dbSNP","id":"rs587782423"}],"featureId":"VAR_044607","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044608","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044609","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044610","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044611","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2946935"}],"featureId":"VAR_044612","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044613","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044614","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044615","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044616","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_005857","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044617","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044618","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1060501204","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501204"}],"featureId":"VAR_044619","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044620","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs534447939","featureCrossReferences":[{"database":"dbSNP","id":"rs534447939"}],"featureId":"VAR_044621","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044622","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs201717599","featureCrossReferences":[{"database":"dbSNP","id":"rs201717599"}],"featureId":"VAR_044623","alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs201717599","featureCrossReferences":[{"database":"dbSNP","id":"rs201717599"}],"featureId":"VAR_044624","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044625","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044626","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044627","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044628","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044629","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005858","alternativeSequence":{"originalSequence":"P","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044630","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526631","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526631"}],"featureId":"VAR_044631","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730881994","featureCrossReferences":[{"database":"dbSNP","id":"rs730881994"}],"featureId":"VAR_044632","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044633","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526625","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526625"}],"featureId":"VAR_044634","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044635","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044636","alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044637","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1210700121","featureCrossReferences":[{"database":"dbSNP","id":"rs1210700121"}],"featureId":"VAR_044638","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044639","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044640","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044641","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044642","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005859","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044643","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044644","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044645","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044646","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044647","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044648","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044649","alternativeSequence":{"originalSequence":"V","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"in familial cancer not matching LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs730882023","featureCrossReferences":[{"database":"dbSNP","id":"rs730882023"}],"featureId":"VAR_044650","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1245723119","featureCrossReferences":[{"database":"dbSNP","id":"rs1245723119"}],"featureId":"VAR_044651","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044652","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044653","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044654","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044655","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs878854069","featureCrossReferences":[{"database":"dbSNP","id":"rs878854069"}],"featureId":"VAR_044656","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044657","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786202717","featureCrossReferences":[{"database":"dbSNP","id":"rs786202717"}],"featureId":"VAR_044658","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044659","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044660","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_044661","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587781504","featureCrossReferences":[{"database":"dbSNP","id":"rs587781504"}],"featureId":"VAR_044662","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1060501195","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501195"}],"featureId":"VAR_044663","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1060501195","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501195"}],"featureId":"VAR_044664","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044665","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044666","alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1555526581","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526581"}],"featureId":"VAR_044667","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs587782447","featureCrossReferences":[{"database":"dbSNP","id":"rs587782447"}],"featureId":"VAR_044668","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044669","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs368771578","featureCrossReferences":[{"database":"dbSNP","id":"rs368771578"}],"featureId":"VAR_044670","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044671","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782461","featureCrossReferences":[{"database":"dbSNP","id":"rs587782461"}],"featureId":"VAR_044672","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044673","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044674","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064796722","featureCrossReferences":[{"database":"dbSNP","id":"rs1064796722"}],"featureId":"VAR_044675","alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587781371","featureCrossReferences":[{"database":"dbSNP","id":"rs587781371"}],"featureId":"VAR_005860","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044676","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs11540654","featureCrossReferences":[{"database":"dbSNP","id":"rs11540654"}],"featureId":"VAR_044677","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; dbSNP:rs11540654","featureCrossReferences":[{"database":"dbSNP","id":"rs11540654"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20385133"}],"featureId":"VAR_005861","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs11540654","featureCrossReferences":[{"database":"dbSNP","id":"rs11540654"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"}],"featureId":"VAR_005862","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs587781371","featureCrossReferences":[{"database":"dbSNP","id":"rs587781371"}],"featureId":"VAR_044678","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044679","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519997","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519997"}],"featureId":"VAR_044680","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519997","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519997"}],"featureId":"VAR_044681","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519997","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519997"}],"featureId":"VAR_044682","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044683","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1423803759","featureCrossReferences":[{"database":"dbSNP","id":"rs1423803759"}],"featureId":"VAR_044684","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005863","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045788","alternativeSequence":{"originalSequence":"F","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044685","alternativeSequence":{"originalSequence":"F","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044686","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044687","alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587781642","featureCrossReferences":[{"database":"dbSNP","id":"rs587781642"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"}],"featureId":"VAR_033033","alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044688","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044689","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044690","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044691","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs755238756","featureCrossReferences":[{"database":"dbSNP","id":"rs755238756"}],"featureId":"VAR_044692","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526518","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526518"}],"featureId":"VAR_044693","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044694","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064794141","featureCrossReferences":[{"database":"dbSNP","id":"rs1064794141"}],"featureId":"VAR_044695","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044696","alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044697","alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044698","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; abolished acetylation; impaired ability to induce proapoptotic program; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity; dbSNP:rs121912658","featureCrossReferences":[{"database":"dbSNP","id":"rs121912658"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17189187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}],"featureId":"VAR_044699","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17189187"}],"featureId":"VAR_044700","alternativeSequence":{"originalSequence":"K","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity; dbSNP:rs121912658","featureCrossReferences":[{"database":"dbSNP","id":"rs121912658"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}],"featureId":"VAR_044701","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17189187"}],"featureId":"VAR_044702","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044703","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044704","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1555526486","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526486"}],"featureId":"VAR_044705","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044706","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs730881997","featureCrossReferences":[{"database":"dbSNP","id":"rs730881997"}],"featureId":"VAR_044707","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044708","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730881997","featureCrossReferences":[{"database":"dbSNP","id":"rs730881997"}],"featureId":"VAR_044709","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044710","alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044711","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044712","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201057","featureCrossReferences":[{"database":"dbSNP","id":"rs786201057"}],"featureId":"VAR_044713","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201057","featureCrossReferences":[{"database":"dbSNP","id":"rs786201057"}],"featureId":"VAR_005864","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1057520003","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520003"}],"featureId":"VAR_044714","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201057","featureCrossReferences":[{"database":"dbSNP","id":"rs786201057"}],"featureId":"VAR_044715","alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1555526335","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526335"}],"featureId":"VAR_044716","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs886039483","featureCrossReferences":[{"database":"dbSNP","id":"rs886039483"}],"featureId":"VAR_005865","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044717","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045789","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044718","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs886039483","featureCrossReferences":[{"database":"dbSNP","id":"rs886039483"}],"featureId":"VAR_005866","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044719","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs730881999","featureCrossReferences":[{"database":"dbSNP","id":"rs730881999"}],"featureId":"VAR_044720","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730881999","featureCrossReferences":[{"database":"dbSNP","id":"rs730881999"}],"featureId":"VAR_005867","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044721","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044722","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044723","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044724","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044725","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044726","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005868","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005869","alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044727","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1438095083","featureCrossReferences":[{"database":"dbSNP","id":"rs1438095083"}],"featureId":"VAR_044728","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs137852792","featureCrossReferences":[{"database":"dbSNP","id":"rs137852792"}],"featureId":"VAR_044729","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs863224683","featureCrossReferences":[{"database":"dbSNP","id":"rs863224683"}],"featureId":"VAR_044730","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044731","alternativeSequence":{"originalSequence":"L","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044732","alternativeSequence":{"originalSequence":"L","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1131691013","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691013"}],"featureId":"VAR_044733","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005870","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs863224683","featureCrossReferences":[{"database":"dbSNP","id":"rs863224683"}],"featureId":"VAR_044734","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044735","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044736","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1131691037","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691037"}],"featureId":"VAR_044737","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs769270327","featureCrossReferences":[{"database":"dbSNP","id":"rs769270327"}],"featureId":"VAR_005872","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005871","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044738","alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782160","featureCrossReferences":[{"database":"dbSNP","id":"rs587782160"}],"featureId":"VAR_044739","alternativeSequence":{"originalSequence":"N","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047159","alternativeSequence":{"originalSequence":"KM","alternativeSequences":["NL"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs747342068","featureCrossReferences":[{"database":"dbSNP","id":"rs747342068"}],"featureId":"VAR_044740","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045790","alternativeSequence":{"originalSequence":"K","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519996","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519996"}],"featureId":"VAR_005873","alternativeSequence":{"originalSequence":"K","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs866775781","featureCrossReferences":[{"database":"dbSNP","id":"rs866775781"}],"featureId":"VAR_044741","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs747342068","featureCrossReferences":[{"database":"dbSNP","id":"rs747342068"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1694291"}],"featureId":"VAR_005874","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519996","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519996"}],"featureId":"VAR_044742","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519996","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519996"}],"featureId":"VAR_044743","alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045791","alternativeSequence":{"originalSequence":"K","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064795139","featureCrossReferences":[{"database":"dbSNP","id":"rs1064795139"}],"featureId":"VAR_044744","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044745","alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044746","alternativeSequence":{"originalSequence":"M","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_044747","alternativeSequence":{"originalSequence":"M","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934873","featureCrossReferences":[{"database":"dbSNP","id":"rs28934873"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1933902"}],"featureId":"VAR_005875","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057280220","featureCrossReferences":[{"database":"dbSNP","id":"rs1057280220"}],"featureId":"VAR_044748","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs780442292","featureCrossReferences":[{"database":"dbSNP","id":"rs780442292"}],"featureId":"VAR_044749","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044750","alternativeSequence":{"originalSequence":"F","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs267605077","featureCrossReferences":[{"database":"dbSNP","id":"rs267605077"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_036504","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044751","alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044752","alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587781991","featureCrossReferences":[{"database":"dbSNP","id":"rs587781991"}],"featureId":"VAR_005877","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519975","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519975"}],"featureId":"VAR_044753","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519975","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519975"}],"featureId":"VAR_044754","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519975","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519975"}],"featureId":"VAR_005876","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045792","alternativeSequence":{"originalSequence":"C","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519976","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519976"}],"featureId":"VAR_044755","alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; decreased E6-mediated binding to E6-AP; dbSNP:rs587781991","featureCrossReferences":[{"database":"dbSNP","id":"rs587781991"}],"featureId":"VAR_044756","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526268","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526268"}],"featureId":"VAR_005878","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs758781593","featureCrossReferences":[{"database":"dbSNP","id":"rs758781593"}],"featureId":"VAR_044757","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_005879","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044758","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044759","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044760","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044761","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005880","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044762","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044763","alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934875","featureCrossReferences":[{"database":"dbSNP","id":"rs28934875"}],"featureId":"VAR_005881","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in LFS; germline mutation","featureId":"VAR_044764","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044765","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs750600586","featureCrossReferences":[{"database":"dbSNP","id":"rs750600586"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27657329"}],"featureId":"VAR_033034","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity; dbSNP:rs1212996409","featureCrossReferences":[{"database":"dbSNP","id":"rs1212996409"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}],"featureId":"VAR_044766","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14660794"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}],"featureId":"VAR_005882","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}],"featureId":"VAR_044767","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044768","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38653238"}],"featureId":"VAR_044769","alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044770","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044771","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs786202561","featureCrossReferences":[{"database":"dbSNP","id":"rs786202561"}],"featureId":"VAR_044772","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044773","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044774","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045793","alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587781288","featureCrossReferences":[{"database":"dbSNP","id":"rs587781288"}],"featureId":"VAR_005885","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519978","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519978"}],"featureId":"VAR_005884","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519978","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519978"}],"featureId":"VAR_044775","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519978","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519978"}],"featureId":"VAR_044776","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519977","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519977"}],"featureId":"VAR_044777","alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587781288","featureCrossReferences":[{"database":"dbSNP","id":"rs587781288"}],"featureId":"VAR_005886","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044778","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045794","alternativeSequence":{"originalSequence":"P","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044779","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs779196500","featureCrossReferences":[{"database":"dbSNP","id":"rs779196500"}],"featureId":"VAR_044780","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044781","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044782","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044783","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius; severely represses interaction with ZNF385A","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17719541"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8013454"}],"featureId":"VAR_005887","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044784","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526241","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526241"}],"featureId":"VAR_044785","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782620","featureCrossReferences":[{"database":"dbSNP","id":"rs587782620"}],"featureId":"VAR_044786","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782620","featureCrossReferences":[{"database":"dbSNP","id":"rs587782620"}],"featureId":"VAR_044787","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201419","featureCrossReferences":[{"database":"dbSNP","id":"rs786201419"}],"featureId":"VAR_044788","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044789","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs786203071","featureCrossReferences":[{"database":"dbSNP","id":"rs786203071"}],"featureId":"VAR_044790","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786203071","featureCrossReferences":[{"database":"dbSNP","id":"rs786203071"}],"featureId":"VAR_005888","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044791","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044792","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782197","featureCrossReferences":[{"database":"dbSNP","id":"rs587782197"}],"featureId":"VAR_005889","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005890","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044793","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044794","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044795","alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786203064","featureCrossReferences":[{"database":"dbSNP","id":"rs786203064"}],"featureId":"VAR_044796","alternativeSequence":{"originalSequence":"W","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044797","alternativeSequence":{"originalSequence":"W","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044798","alternativeSequence":{"originalSequence":"W","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044799","alternativeSequence":{"originalSequence":"W","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044800","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005891","alternativeSequence":{"originalSequence":"V","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044801","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044802","alternativeSequence":{"originalSequence":"V","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1453167097","featureCrossReferences":[{"database":"dbSNP","id":"rs1453167097"}],"featureId":"VAR_005892","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526226","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526226"}],"featureId":"VAR_044803","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1046611742","featureCrossReferences":[{"database":"dbSNP","id":"rs1046611742"}],"featureId":"VAR_044804","alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044805","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044806","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044807","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044808","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1131691007","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691007"}],"featureId":"VAR_044809","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526214","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526214"}],"featureId":"VAR_044810","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005893","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044811","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044812","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044813","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044814","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044815","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044816","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044817","alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs28934874","featureCrossReferences":[{"database":"dbSNP","id":"rs28934874"}],"featureId":"VAR_005894","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520000","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520000"}],"featureId":"VAR_044818","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044819","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520000","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520000"}],"featureId":"VAR_044820","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934874","featureCrossReferences":[{"database":"dbSNP","id":"rs28934874"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7682763"}],"featureId":"VAR_005895","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934874","featureCrossReferences":[{"database":"dbSNP","id":"rs28934874"}],"featureId":"VAR_005896","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044821","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587782705","featureCrossReferences":[{"database":"dbSNP","id":"rs587782705"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1868473"}],"featureId":"VAR_005897","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044822","alternativeSequence":{"originalSequence":"P","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044823","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs767328513","featureCrossReferences":[{"database":"dbSNP","id":"rs767328513"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9450901"}],"featureId":"VAR_005898","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044824","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044825","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045795","alternativeSequence":{"originalSequence":"P","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044826","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044827","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044828","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064795860","featureCrossReferences":[{"database":"dbSNP","id":"rs1064795860"}],"featureId":"VAR_044829","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005899","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044830","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044831","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs762846821","featureCrossReferences":[{"database":"dbSNP","id":"rs762846821"}],"featureId":"VAR_044832","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045796","alternativeSequence":{"originalSequence":"G","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs137852789","featureCrossReferences":[{"database":"dbSNP","id":"rs137852789"}],"featureId":"VAR_044833","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs762846821","featureCrossReferences":[{"database":"dbSNP","id":"rs762846821"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2263646"}],"featureId":"VAR_005900","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs772683278","featureCrossReferences":[{"database":"dbSNP","id":"rs772683278"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1868473"}],"featureId":"VAR_005901","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044834","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044835","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs786202752","featureCrossReferences":[{"database":"dbSNP","id":"rs786202752"}],"featureId":"VAR_044836","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; does not induce SNAI1 degradation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14660794"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20385133"}],"featureId":"VAR_044837","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786202752","featureCrossReferences":[{"database":"dbSNP","id":"rs786202752"}],"featureId":"VAR_044838","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs563378859","featureCrossReferences":[{"database":"dbSNP","id":"rs563378859"}],"featureId":"VAR_044839","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044840","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs371524413","featureCrossReferences":[{"database":"dbSNP","id":"rs371524413"}],"featureId":"VAR_044841","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044842","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7682763"}],"featureId":"VAR_005902","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044843","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1131691023","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691023"}],"featureId":"VAR_044844","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005903","alternativeSequence":{"originalSequence":"V","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912654","featureCrossReferences":[{"database":"dbSNP","id":"rs121912654"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_005904","alternativeSequence":{"originalSequence":"V","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044845","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912654","featureCrossReferences":[{"database":"dbSNP","id":"rs121912654"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9419979"}],"featureId":"VAR_012977","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044846","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780068","featureCrossReferences":[{"database":"dbSNP","id":"rs587780068"}],"featureId":"VAR_005905","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045797","alternativeSequence":{"originalSequence":"R","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_005906","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587782144","featureCrossReferences":[{"database":"dbSNP","id":"rs587782144"}],"featureId":"VAR_005907","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044847","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782144","featureCrossReferences":[{"database":"dbSNP","id":"rs587782144"}],"featureId":"VAR_044848","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044849","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044850","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045798","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044851","alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions; dbSNP:rs730882022","featureCrossReferences":[{"database":"dbSNP","id":"rs730882022"}],"featureId":"VAR_045799","alternativeSequence":{"originalSequence":"A","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044852","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882000","featureCrossReferences":[{"database":"dbSNP","id":"rs730882000"}],"featureId":"VAR_044853","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044854","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882000","featureCrossReferences":[{"database":"dbSNP","id":"rs730882000"}],"featureId":"VAR_044855","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526131","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526131"}],"featureId":"VAR_044856","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047160","alternativeSequence":{"originalSequence":"MA","alternativeSequences":["IP"]}},{"type":"Natural variant","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047161","alternativeSequence":{"originalSequence":"MA","alternativeSequences":["IS"]}},{"type":"Natural variant","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047162","alternativeSequence":{"originalSequence":"MA","alternativeSequences":["IT"]}},{"type":"Natural variant","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs772354334","featureCrossReferences":[{"database":"dbSNP","id":"rs772354334"}],"featureId":"VAR_005908","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044857","alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044858","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs377274728","featureCrossReferences":[{"database":"dbSNP","id":"rs377274728"}],"featureId":"VAR_044859","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064795691","featureCrossReferences":[{"database":"dbSNP","id":"rs1064795691"}],"featureId":"VAR_044860","alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045800","alternativeSequence":{"originalSequence":"A","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044861","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044862","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005909","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs193920817","featureCrossReferences":[{"database":"dbSNP","id":"rs193920817"}],"featureId":"VAR_044863","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044864","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044865","alternativeSequence":{"originalSequence":"I","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044866","alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in a breast cancer with no family history; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_044867","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780069","featureCrossReferences":[{"database":"dbSNP","id":"rs587780069"}],"featureId":"VAR_005910","alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044868","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005911","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs148924904","featureCrossReferences":[{"database":"dbSNP","id":"rs148924904"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"}],"featureId":"VAR_033035","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786203436","featureCrossReferences":[{"database":"dbSNP","id":"rs786203436"}],"featureId":"VAR_044869","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044870","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786203436","featureCrossReferences":[{"database":"dbSNP","id":"rs786203436"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"}],"featureId":"VAR_005912","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786203436","featureCrossReferences":[{"database":"dbSNP","id":"rs786203436"}],"featureId":"VAR_044871","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044872","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs879254249","featureCrossReferences":[{"database":"dbSNP","id":"rs879254249"}],"featureId":"VAR_044873","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044874","alternativeSequence":{"originalSequence":"K","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1131691034","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691034"}],"featureId":"VAR_005913","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005914","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044875","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044876","alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044877","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044878","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005915","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044879","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005916","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044880","alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044881","alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526101","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526101"}],"featureId":"VAR_005917","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044882","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044883","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047163","alternativeSequence":{"originalSequence":"QH","alternativeSequences":["HD"]}},{"type":"Natural variant","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047164","alternativeSequence":{"originalSequence":"QH","alternativeSequences":["YL"]}},{"type":"Natural variant","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044884","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in a sporadic cancer; somatic mutation","featureId":"VAR_044885","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044886","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044887","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047165","alternativeSequence":{"originalSequence":"HM","alternativeSequences":["LI"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044888","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044889","alternativeSequence":{"originalSequence":"H","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044890","alternativeSequence":{"originalSequence":"H","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044891","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044892","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs867114783","featureCrossReferences":[{"database":"dbSNP","id":"rs867114783"}],"featureId":"VAR_005918","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045801","alternativeSequence":{"originalSequence":"H","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044893","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047166","alternativeSequence":{"originalSequence":"MT","alternativeSequences":["IS"]}},{"type":"Natural variant","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9450901"}],"featureId":"VAR_005919","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044894","alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005920","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044895","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780729","featureCrossReferences":[{"database":"dbSNP","id":"rs587780729"}],"featureId":"VAR_044896","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044897","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs779000871","featureCrossReferences":[{"database":"dbSNP","id":"rs779000871"}],"featureId":"VAR_005921","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044898","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005922","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044899","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044900","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044901","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587781845","featureCrossReferences":[{"database":"dbSNP","id":"rs587781845"}],"featureId":"VAR_044902","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044903","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044904","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005923","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044905","alternativeSequence":{"originalSequence":"V","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1131691043","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691043"}],"featureId":"VAR_044906","alternativeSequence":{"originalSequence":"V","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1131691021","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691021"}],"featureId":"VAR_044907","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044908","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519747","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519747"}],"featureId":"VAR_044909","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519747","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519747"}],"featureId":"VAR_005924","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519747","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519747"}],"featureId":"VAR_044910","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876660754","featureCrossReferences":[{"database":"dbSNP","id":"rs876660754"}],"featureId":"VAR_005925","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs876660754","featureCrossReferences":[{"database":"dbSNP","id":"rs876660754"}],"featureId":"VAR_005926","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045802","alternativeSequence":{"originalSequence":"V","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs864622115","featureCrossReferences":[{"database":"dbSNP","id":"rs864622115"}],"featureId":"VAR_044911","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064796681","featureCrossReferences":[{"database":"dbSNP","id":"rs1064796681"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7682763"}],"featureId":"VAR_005927","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044912","alternativeSequence":{"originalSequence":"R","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044913","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044914","alternativeSequence":{"originalSequence":"R","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044915","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs138729528","featureCrossReferences":[{"database":"dbSNP","id":"rs138729528"}],"featureId":"VAR_005928","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs138729528","featureCrossReferences":[{"database":"dbSNP","id":"rs138729528"}],"featureId":"VAR_005929","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; reduces interaction with ZNF385A; dbSNP:rs28934578","featureCrossReferences":[{"database":"dbSNP","id":"rs28934578"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17719541"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1868473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20385133"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27657329"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887414"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8825920"}],"featureId":"VAR_005932","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934578","featureCrossReferences":[{"database":"dbSNP","id":"rs28934578"}],"featureId":"VAR_005930","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17719541"}],"featureId":"VAR_005931","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044916","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044917","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047167","alternativeSequence":{"originalSequence":"CP","alternativeSequences":["FS"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786202962","featureCrossReferences":[{"database":"dbSNP","id":"rs786202962"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1394225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1868473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8829627"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9450901"}],"featureId":"VAR_005933","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044918","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044919","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs967461896","featureCrossReferences":[{"database":"dbSNP","id":"rs967461896"}],"featureId":"VAR_044920","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519980","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519980"}],"featureId":"VAR_005934","alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786202962","featureCrossReferences":[{"database":"dbSNP","id":"rs786202962"}],"featureId":"VAR_044921","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044922","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045803","alternativeSequence":{"originalSequence":"P","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044923","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045804","alternativeSequence":{"originalSequence":"P","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs751477326","featureCrossReferences":[{"database":"dbSNP","id":"rs751477326"}],"featureId":"VAR_005935","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs751477326","featureCrossReferences":[{"database":"dbSNP","id":"rs751477326"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_036505","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs147002414","featureCrossReferences":[{"database":"dbSNP","id":"rs147002414"}],"featureId":"VAR_044924","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044925","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047168","alternativeSequence":{"originalSequence":"HH","alternativeSequences":["QS"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044926","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in a Burkitt lymphoma","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1303181"}],"featureId":"VAR_005936","alternativeSequence":{"originalSequence":"H","alternativeSequences":["HPHP"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044927","alternativeSequence":{"originalSequence":"H","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064795203","featureCrossReferences":[{"database":"dbSNP","id":"rs1064795203"}],"featureId":"VAR_044928","alternativeSequence":{"originalSequence":"H","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555526004","featureCrossReferences":[{"database":"dbSNP","id":"rs1555526004"}],"featureId":"VAR_044929","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044930","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044931","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044932","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780070","featureCrossReferences":[{"database":"dbSNP","id":"rs587780070"}],"featureId":"VAR_044933","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519991","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519991"}],"featureId":"VAR_044934","alternativeSequence":{"originalSequence":"H","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780070","featureCrossReferences":[{"database":"dbSNP","id":"rs587780070"}],"featureId":"VAR_044935","alternativeSequence":{"originalSequence":"H","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519991","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519991"}],"featureId":"VAR_044936","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876660821","featureCrossReferences":[{"database":"dbSNP","id":"rs876660821"}],"featureId":"VAR_044937","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519991","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519991"}],"featureId":"VAR_044938","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587780070","featureCrossReferences":[{"database":"dbSNP","id":"rs587780070"}],"featureId":"VAR_044939","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044940","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044941","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044942","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs879253911","featureCrossReferences":[{"database":"dbSNP","id":"rs879253911"}],"featureId":"VAR_044943","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044944","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044945","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587782596","featureCrossReferences":[{"database":"dbSNP","id":"rs587782596"}],"featureId":"VAR_044946","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044947","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs397514495","featureCrossReferences":[{"database":"dbSNP","id":"rs397514495"}],"featureId":"VAR_044948","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs397514495","featureCrossReferences":[{"database":"dbSNP","id":"rs397514495"}],"featureId":"VAR_005937","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_044949","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782596","featureCrossReferences":[{"database":"dbSNP","id":"rs587782596"}],"featureId":"VAR_044950","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044951","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005938","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044952","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525970","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525970"}],"featureId":"VAR_044953","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044954","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1060501209","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501209"}],"featureId":"VAR_044955","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044956","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs72661117","featureCrossReferences":[{"database":"dbSNP","id":"rs72661117"}],"featureId":"VAR_047169","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044957","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005939","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044958","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044959","alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044960","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs150607408","featureCrossReferences":[{"database":"dbSNP","id":"rs150607408"}],"featureId":"VAR_044961","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044962","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044963","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs375275361","featureCrossReferences":[{"database":"dbSNP","id":"rs375275361"}],"featureId":"VAR_044964","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044965","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044966","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1060501206","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501206"}],"featureId":"VAR_044967","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044968","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_005940","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005941","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044969","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045805","alternativeSequence":{"originalSequence":"G","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044970","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs776167460","featureCrossReferences":[{"database":"dbSNP","id":"rs776167460"}],"featureId":"VAR_005942","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044971","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1199893366","featureCrossReferences":[{"database":"dbSNP","id":"rs1199893366"}],"featureId":"VAR_044972","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044973","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044974","alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044975","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005943","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1555525921","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525921"}],"featureId":"VAR_044976","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044977","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912665","featureCrossReferences":[{"database":"dbSNP","id":"rs121912665"}],"featureId":"VAR_044978","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044979","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044980","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876660825","featureCrossReferences":[{"database":"dbSNP","id":"rs876660825"}],"featureId":"VAR_005944","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876660825","featureCrossReferences":[{"database":"dbSNP","id":"rs876660825"}],"featureId":"VAR_044981","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044982","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876660254","featureCrossReferences":[{"database":"dbSNP","id":"rs876660254"}],"featureId":"VAR_044983","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587778718","featureCrossReferences":[{"database":"dbSNP","id":"rs587778718"}],"featureId":"VAR_044984","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587778718","featureCrossReferences":[{"database":"dbSNP","id":"rs587778718"}],"featureId":"VAR_044985","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587778718","featureCrossReferences":[{"database":"dbSNP","id":"rs587778718"}],"featureId":"VAR_044986","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs868590738","featureCrossReferences":[{"database":"dbSNP","id":"rs868590738"}],"featureId":"VAR_044987","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005945","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047170","alternativeSequence":{"originalSequence":"QH","alternativeSequences":["HN"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047171","alternativeSequence":{"originalSequence":"QH","alternativeSequences":["HY"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044988","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_044989","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044990","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044991","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882002","featureCrossReferences":[{"database":"dbSNP","id":"rs730882002"}],"featureId":"VAR_005946","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876658468","featureCrossReferences":[{"database":"dbSNP","id":"rs876658468"}],"featureId":"VAR_005947","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201838","featureCrossReferences":[{"database":"dbSNP","id":"rs786201838"}],"featureId":"VAR_044992","alternativeSequence":{"originalSequence":"H","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876658468","featureCrossReferences":[{"database":"dbSNP","id":"rs876658468"}],"featureId":"VAR_044993","alternativeSequence":{"originalSequence":"H","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201838","featureCrossReferences":[{"database":"dbSNP","id":"rs786201838"}],"featureId":"VAR_044994","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044995","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs786201838","featureCrossReferences":[{"database":"dbSNP","id":"rs786201838"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887414"}],"featureId":"VAR_005948","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876658468","featureCrossReferences":[{"database":"dbSNP","id":"rs876658468"}],"featureId":"VAR_044996","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780071","featureCrossReferences":[{"database":"dbSNP","id":"rs587780071"}],"featureId":"VAR_044997","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519998","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519998"}],"featureId":"VAR_044998","alternativeSequence":{"originalSequence":"L","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_044999","alternativeSequence":{"originalSequence":"L","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519998","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519998"}],"featureId":"VAR_005949","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519998","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519998"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7682763"}],"featureId":"VAR_005950","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045000","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs942158624","featureCrossReferences":[{"database":"dbSNP","id":"rs942158624"}],"featureId":"VAR_045001","alternativeSequence":{"originalSequence":"I","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047172","alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs760043106","featureCrossReferences":[{"database":"dbSNP","id":"rs760043106"}],"featureId":"VAR_045002","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs760043106","featureCrossReferences":[{"database":"dbSNP","id":"rs760043106"}],"featureId":"VAR_045003","alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs760043106","featureCrossReferences":[{"database":"dbSNP","id":"rs760043106"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9450901"}],"featureId":"VAR_005951","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045004","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045806","alternativeSequence":{"originalSequence":"I","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs397516435","featureCrossReferences":[{"database":"dbSNP","id":"rs397516435"}],"featureId":"VAR_045005","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs483352697","featureCrossReferences":[{"database":"dbSNP","id":"rs483352697"}],"featureId":"VAR_045006","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs483352697","featureCrossReferences":[{"database":"dbSNP","id":"rs483352697"}],"featureId":"VAR_045007","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs483352697","featureCrossReferences":[{"database":"dbSNP","id":"rs483352697"}],"featureId":"VAR_045008","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045009","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_045010","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045011","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786204041","featureCrossReferences":[{"database":"dbSNP","id":"rs786204041"}],"featureId":"VAR_045012","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs786204041","featureCrossReferences":[{"database":"dbSNP","id":"rs786204041"}],"featureId":"VAR_045013","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045014","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045015","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005952","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045016","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045017","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045018","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045019","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045020","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525857","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525857"}],"featureId":"VAR_045021","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045022","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045023","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045024","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045807","alternativeSequence":{"originalSequence":"N","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045025","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045026","alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047173","alternativeSequence":{"originalSequence":"LR","alternativeSequences":["FC"]}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882024","featureCrossReferences":[{"database":"dbSNP","id":"rs730882024"}],"featureId":"VAR_045027","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045028","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045029","alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780072","featureCrossReferences":[{"database":"dbSNP","id":"rs587780072"}],"featureId":"VAR_045030","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780072","featureCrossReferences":[{"database":"dbSNP","id":"rs587780072"}],"featureId":"VAR_045031","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587778719","featureCrossReferences":[{"database":"dbSNP","id":"rs587778719"}],"featureId":"VAR_045032","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587778719","featureCrossReferences":[{"database":"dbSNP","id":"rs587778719"}],"featureId":"VAR_045033","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045034","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045035","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047174","alternativeSequence":{"originalSequence":"VE","alternativeSequences":["LV"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045036","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045037","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045038","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882003","featureCrossReferences":[{"database":"dbSNP","id":"rs730882003"}],"featureId":"VAR_045039","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045808","alternativeSequence":{"originalSequence":"V","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045040","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045041","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1260903787","featureCrossReferences":[{"database":"dbSNP","id":"rs1260903787"}],"featureId":"VAR_045042","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045043","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045044","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045045","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520007","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520007"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1459726"}],"featureId":"VAR_005953","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520008","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520008"}],"featureId":"VAR_005954","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520007","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520007"}],"featureId":"VAR_047175","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520008","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520008"}],"featureId":"VAR_045046","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520008","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520008"}],"featureId":"VAR_045047","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520007","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520007"}],"featureId":"VAR_045048","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045049","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045050","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047176","alternativeSequence":{"originalSequence":"DD","alternativeSequences":["EY"]}},{"type":"Natural variant","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045051","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045052","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045053","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs923100890","featureCrossReferences":[{"database":"dbSNP","id":"rs923100890"}],"featureId":"VAR_045054","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045055","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045056","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045057","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045058","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045059","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045809","alternativeSequence":{"originalSequence":"D","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045060","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1464727668","featureCrossReferences":[{"database":"dbSNP","id":"rs1464727668"}],"featureId":"VAR_045061","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045062","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045063","alternativeSequence":{"originalSequence":"R","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045064","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045065","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045066","alternativeSequence":{"originalSequence":"R","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045067","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045068","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045069","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045070","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045071","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045072","alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation; dbSNP:rs1060501200","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501200"}],"featureId":"VAR_045073","alternativeSequence":{"originalSequence":"N","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1060501198","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501198"}],"featureId":"VAR_045074","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045075","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045076","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045077","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045078","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064795766","featureCrossReferences":[{"database":"dbSNP","id":"rs1064795766"}],"featureId":"VAR_045079","alternativeSequence":{"originalSequence":"F","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045080","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045081","alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045082","alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045083","alternativeSequence":{"originalSequence":"F","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs397516436","featureCrossReferences":[{"database":"dbSNP","id":"rs397516436"}],"featureId":"VAR_045084","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587778720","featureCrossReferences":[{"database":"dbSNP","id":"rs587778720"}],"featureId":"VAR_045085","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587778720","featureCrossReferences":[{"database":"dbSNP","id":"rs587778720"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_036506","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587778720","featureCrossReferences":[{"database":"dbSNP","id":"rs587778720"}],"featureId":"VAR_005955","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045086","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045087","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1057519992","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519992"}],"featureId":"VAR_045088","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587781386","featureCrossReferences":[{"database":"dbSNP","id":"rs587781386"}],"featureId":"VAR_047177","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519992","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519992"}],"featureId":"VAR_045089","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045090","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045091","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs886039484","featureCrossReferences":[{"database":"dbSNP","id":"rs886039484"}],"featureId":"VAR_045092","alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782177","featureCrossReferences":[{"database":"dbSNP","id":"rs587782177"}],"featureId":"VAR_045093","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045810","alternativeSequence":{"originalSequence":"S","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782177","featureCrossReferences":[{"database":"dbSNP","id":"rs587782177"}],"featureId":"VAR_045094","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520001","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520001"}],"featureId":"VAR_045095","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782177","featureCrossReferences":[{"database":"dbSNP","id":"rs587782177"}],"featureId":"VAR_045096","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045097","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520004","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520004"}],"featureId":"VAR_045098","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520004","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520004"}],"featureId":"VAR_045099","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882025","featureCrossReferences":[{"database":"dbSNP","id":"rs730882025"}],"featureId":"VAR_045100","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882025","featureCrossReferences":[{"database":"dbSNP","id":"rs730882025"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"}],"featureId":"VAR_005956","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045811","alternativeSequence":{"originalSequence":"V","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045101","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045102","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045103","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045104","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045105","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in dbSNP:rs35163653","featureCrossReferences":[{"database":"dbSNP","id":"rs35163653"}],"featureId":"VAR_047178","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045106","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045107","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525743","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525743"}],"featureId":"VAR_045108","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045109","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs878854072","featureCrossReferences":[{"database":"dbSNP","id":"rs878854072"}],"featureId":"VAR_045110","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045812","alternativeSequence":{"originalSequence":"P","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045111","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1420675064","featureCrossReferences":[{"database":"dbSNP","id":"rs1420675064"}],"featureId":"VAR_045112","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045113","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs879253894","featureCrossReferences":[{"database":"dbSNP","id":"rs879253894"}],"featureId":"VAR_045114","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045115","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912666","featureCrossReferences":[{"database":"dbSNP","id":"rs121912666"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7682763"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9450901"}],"featureId":"VAR_005957","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs530941076","featureCrossReferences":[{"database":"dbSNP","id":"rs530941076"}],"featureId":"VAR_045116","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045117","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs530941076","featureCrossReferences":[{"database":"dbSNP","id":"rs530941076"}],"featureId":"VAR_005958","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs530941076","featureCrossReferences":[{"database":"dbSNP","id":"rs530941076"}],"featureId":"VAR_045118","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912666","featureCrossReferences":[{"database":"dbSNP","id":"rs121912666"}],"featureId":"VAR_005959","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045119","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045120","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045121","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201592","featureCrossReferences":[{"database":"dbSNP","id":"rs786201592"}],"featureId":"VAR_045122","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045123","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045124","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs146340390","featureCrossReferences":[{"database":"dbSNP","id":"rs146340390"}],"featureId":"VAR_045125","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045126","alternativeSequence":{"originalSequence":"P","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045127","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1060501203","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501203"}],"featureId":"VAR_045128","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045129","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047179","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs138983188","featureCrossReferences":[{"database":"dbSNP","id":"rs138983188"}],"featureId":"VAR_045130","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs138983188","featureCrossReferences":[{"database":"dbSNP","id":"rs138983188"}],"featureId":"VAR_045131","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045132","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045133","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045134","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs267605076","featureCrossReferences":[{"database":"dbSNP","id":"rs267605076"}],"featureId":"VAR_045135","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045136","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525707","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525707"}],"featureId":"VAR_045137","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045138","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045139","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045140","alternativeSequence":{"originalSequence":"V","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045141","alternativeSequence":{"originalSequence":"V","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045142","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045143","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs746504075","featureCrossReferences":[{"database":"dbSNP","id":"rs746504075"}],"featureId":"VAR_045144","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045145","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047180","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045844","alternativeSequence":{"originalSequence":"G","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045146","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs970212462","featureCrossReferences":[{"database":"dbSNP","id":"rs970212462"}],"featureId":"VAR_045147","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045148","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045149","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045150","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in a sporadic cancer; somatic mutation","featureId":"VAR_045151","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045152","alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005960","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045153","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045154","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045155","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045845","alternativeSequence":{"originalSequence":"D","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045156","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045157","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045158","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045846","alternativeSequence":{"originalSequence":"C","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064794312","featureCrossReferences":[{"database":"dbSNP","id":"rs1064794312"}],"featureId":"VAR_045159","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045160","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064793603","featureCrossReferences":[{"database":"dbSNP","id":"rs1064793603"}],"featureId":"VAR_045161","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045162","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9450901"}],"featureId":"VAR_005961","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045163","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045164","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045165","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045166","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525564","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525564"}],"featureId":"VAR_045167","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045168","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045169","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045170","alternativeSequence":{"originalSequence":"I","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525562","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525562"}],"featureId":"VAR_045171","alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045172","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; does not induce SNAI1 degradation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20385133"}],"featureId":"VAR_045173","alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587781589","featureCrossReferences":[{"database":"dbSNP","id":"rs587781589"}],"featureId":"VAR_005962","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045174","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in a sporadic cancer; somatic mutation","featureId":"VAR_045175","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045176","alternativeSequence":{"originalSequence":"H","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045177","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045178","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs879254233","featureCrossReferences":[{"database":"dbSNP","id":"rs879254233"}],"featureId":"VAR_047181","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045179","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587780073","featureCrossReferences":[{"database":"dbSNP","id":"rs587780073"}],"featureId":"VAR_005963","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs864622237","featureCrossReferences":[{"database":"dbSNP","id":"rs864622237"}],"featureId":"VAR_045180","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045181","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs864622237","featureCrossReferences":[{"database":"dbSNP","id":"rs864622237"}],"featureId":"VAR_005964","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045847","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs864622237","featureCrossReferences":[{"database":"dbSNP","id":"rs864622237"}],"featureId":"VAR_045182","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045848","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780073","featureCrossReferences":[{"database":"dbSNP","id":"rs587780073"}],"featureId":"VAR_045183","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in an adrenocortical carcinoma with no family history; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_047182","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045184","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs144340710","featureCrossReferences":[{"database":"dbSNP","id":"rs144340710"}],"featureId":"VAR_045185","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045849","alternativeSequence":{"originalSequence":"N","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs144340710","featureCrossReferences":[{"database":"dbSNP","id":"rs144340710"}],"featureId":"VAR_045186","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045187","alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786204145","featureCrossReferences":[{"database":"dbSNP","id":"rs786204145"}],"featureId":"VAR_045188","alternativeSequence":{"originalSequence":"N","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs730882026","featureCrossReferences":[{"database":"dbSNP","id":"rs730882026"}],"featureId":"VAR_045189","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782289","featureCrossReferences":[{"database":"dbSNP","id":"rs587782289"}],"featureId":"VAR_045190","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045191","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782289","featureCrossReferences":[{"database":"dbSNP","id":"rs587782289"}],"featureId":"VAR_045192","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782289","featureCrossReferences":[{"database":"dbSNP","id":"rs587782289"}],"featureId":"VAR_045193","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882026","featureCrossReferences":[{"database":"dbSNP","id":"rs730882026"}],"featureId":"VAR_045194","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587782664","featureCrossReferences":[{"database":"dbSNP","id":"rs587782664"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27657329"}],"featureId":"VAR_005965","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs765848205","featureCrossReferences":[{"database":"dbSNP","id":"rs765848205"}],"featureId":"VAR_045195","alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045196","alternativeSequence":{"originalSequence":"M","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs765848205","featureCrossReferences":[{"database":"dbSNP","id":"rs765848205"}],"featureId":"VAR_045197","alternativeSequence":{"originalSequence":"M","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045198","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882004","featureCrossReferences":[{"database":"dbSNP","id":"rs730882004"}],"featureId":"VAR_045199","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882005","featureCrossReferences":[{"database":"dbSNP","id":"rs730882005"}],"featureId":"VAR_005966","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1057519981","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519981"}],"featureId":"VAR_045200","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045850","alternativeSequence":{"originalSequence":"C","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519981","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519981"}],"featureId":"VAR_045201","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs730882005","featureCrossReferences":[{"database":"dbSNP","id":"rs730882005"}],"featureId":"VAR_045202","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs193920789","featureCrossReferences":[{"database":"dbSNP","id":"rs193920789"}],"featureId":"VAR_045203","alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs730882005","featureCrossReferences":[{"database":"dbSNP","id":"rs730882005"}],"featureId":"VAR_005967","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876660807","featureCrossReferences":[{"database":"dbSNP","id":"rs876660807"}],"featureId":"VAR_045204","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045205","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045206","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057522275","featureCrossReferences":[{"database":"dbSNP","id":"rs1057522275"}],"featureId":"VAR_045207","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519999","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519999"}],"featureId":"VAR_045208","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519999","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519999"}],"featureId":"VAR_045209","alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045210","alternativeSequence":{"originalSequence":"N","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045211","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045212","alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005968","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045213","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045214","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045215","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045216","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520002","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520002"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"}],"featureId":"VAR_033036","alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs28934573","featureCrossReferences":[{"database":"dbSNP","id":"rs28934573"}],"featureId":"VAR_045217","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573","featureCrossReferences":[{"database":"dbSNP","id":"rs28934573"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1699228"}],"featureId":"VAR_005969","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520002","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520002"}],"featureId":"VAR_045218","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_047183","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs28934573","featureCrossReferences":[{"database":"dbSNP","id":"rs28934573"}],"featureId":"VAR_045219","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912655","featureCrossReferences":[{"database":"dbSNP","id":"rs121912655"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1394225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_005970","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519982","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519982"}],"featureId":"VAR_045220","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045221","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912655","featureCrossReferences":[{"database":"dbSNP","id":"rs121912655"}],"featureId":"VAR_045222","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs375874539","featureCrossReferences":[{"database":"dbSNP","id":"rs375874539"}],"featureId":"VAR_045223","alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912655","featureCrossReferences":[{"database":"dbSNP","id":"rs121912655"}],"featureId":"VAR_045224","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047184","alternativeSequence":{"originalSequence":"MG","alternativeSequences":["IC"]}},{"type":"Natural variant","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047185","alternativeSequence":{"originalSequence":"MG","alternativeSequences":["IS"]}},{"type":"Natural variant","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045225","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045226","alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786203117","featureCrossReferences":[{"database":"dbSNP","id":"rs786203117"}],"featureId":"VAR_045227","alternativeSequence":{"originalSequence":"M","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045228","alternativeSequence":{"originalSequence":"M","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882006","featureCrossReferences":[{"database":"dbSNP","id":"rs730882006"}],"featureId":"VAR_045229","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786203117","featureCrossReferences":[{"database":"dbSNP","id":"rs786203117"}],"featureId":"VAR_045230","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs985033810","featureCrossReferences":[{"database":"dbSNP","id":"rs985033810"}],"featureId":"VAR_047186","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519989","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519989"}],"featureId":"VAR_045231","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1057517983","featureCrossReferences":[{"database":"dbSNP","id":"rs1057517983"}],"featureId":"VAR_045232","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045233","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519989","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519989"}],"featureId":"VAR_045234","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519989","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519989"}],"featureId":"VAR_045235","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs985033810","featureCrossReferences":[{"database":"dbSNP","id":"rs985033810"}],"featureId":"VAR_045236","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912656","featureCrossReferences":[{"database":"dbSNP","id":"rs121912656"}],"featureId":"VAR_005971","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575","featureCrossReferences":[{"database":"dbSNP","id":"rs28934575"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1394225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1978757"}],"featureId":"VAR_005972","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912656","featureCrossReferences":[{"database":"dbSNP","id":"rs121912656"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2259385"}],"featureId":"VAR_005973","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045237","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045851","alternativeSequence":{"originalSequence":"G","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045852","alternativeSequence":{"originalSequence":"G","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045853","alternativeSequence":{"originalSequence":"G","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045854","alternativeSequence":{"originalSequence":"G","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs28934575","featureCrossReferences":[{"database":"dbSNP","id":"rs28934575"}],"featureId":"VAR_045238","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575","featureCrossReferences":[{"database":"dbSNP","id":"rs28934575"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8829627"}],"featureId":"VAR_005974","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912656","featureCrossReferences":[{"database":"dbSNP","id":"rs121912656"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2263646"}],"featureId":"VAR_005975","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1019340046","featureCrossReferences":[{"database":"dbSNP","id":"rs1019340046"}],"featureId":"VAR_045239","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045240","alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs483352695","featureCrossReferences":[{"database":"dbSNP","id":"rs483352695"}],"featureId":"VAR_044020","alternativeSequence":{"originalSequence":"M","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780074","featureCrossReferences":[{"database":"dbSNP","id":"rs587780074"}],"featureId":"VAR_005976","alternativeSequence":{"originalSequence":"M","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780074","featureCrossReferences":[{"database":"dbSNP","id":"rs587780074"}],"featureId":"VAR_005977","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs483352695","featureCrossReferences":[{"database":"dbSNP","id":"rs483352695"}],"featureId":"VAR_005978","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047187","alternativeSequence":{"originalSequence":"NR","alternativeSequences":["IP"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047188","alternativeSequence":{"originalSequence":"NR","alternativeSequences":["KW"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1452189221","featureCrossReferences":[{"database":"dbSNP","id":"rs1452189221"}],"featureId":"VAR_045241","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045855","alternativeSequence":{"originalSequence":"N","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201762","featureCrossReferences":[{"database":"dbSNP","id":"rs786201762"}],"featureId":"VAR_005980","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045242","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201762","featureCrossReferences":[{"database":"dbSNP","id":"rs786201762"}],"featureId":"VAR_045243","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047189","alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045244","alternativeSequence":{"originalSequence":"N","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045245","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912651","featureCrossReferences":[{"database":"dbSNP","id":"rs121912651"}],"featureId":"VAR_005981","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs11540652","featureCrossReferences":[{"database":"dbSNP","id":"rs11540652"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1394225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7682763"}],"featureId":"VAR_005982","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs11540652","featureCrossReferences":[{"database":"dbSNP","id":"rs11540652"}],"featureId":"VAR_045246","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652","featureCrossReferences":[{"database":"dbSNP","id":"rs11540652"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2263646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7682763"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887414"}],"featureId":"VAR_005983","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912651","featureCrossReferences":[{"database":"dbSNP","id":"rs121912651"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1978757"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27657329"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8829627"}],"featureId":"VAR_005984","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047190","alternativeSequence":{"originalSequence":"RP","alternativeSequences":["SA"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047191","alternativeSequence":{"originalSequence":"RP","alternativeSequences":["SS"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782082","featureCrossReferences":[{"database":"dbSNP","id":"rs587782082"}],"featureId":"VAR_005985","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045247","alternativeSequence":{"originalSequence":"R","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782329","featureCrossReferences":[{"database":"dbSNP","id":"rs587782329"}],"featureId":"VAR_045248","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782329","featureCrossReferences":[{"database":"dbSNP","id":"rs587782329"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"}],"featureId":"VAR_033037","alternativeSequence":{"originalSequence":"R","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045856","alternativeSequence":{"originalSequence":"R","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; dbSNP:rs28934571","featureCrossReferences":[{"database":"dbSNP","id":"rs28934571"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1694291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20385133"}],"featureId":"VAR_005986","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782329","featureCrossReferences":[{"database":"dbSNP","id":"rs587782329"}],"featureId":"VAR_045249","alternativeSequence":{"originalSequence":"R","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782082","featureCrossReferences":[{"database":"dbSNP","id":"rs587782082"}],"featureId":"VAR_045250","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045251","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045857","alternativeSequence":{"originalSequence":"P","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045252","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064794311","featureCrossReferences":[{"database":"dbSNP","id":"rs1064794311"}],"featureId":"VAR_047192","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045858","alternativeSequence":{"originalSequence":"P","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045253","alternativeSequence":{"originalSequence":"P","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045254","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045255","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045256","alternativeSequence":{"originalSequence":"I","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882007","featureCrossReferences":[{"database":"dbSNP","id":"rs730882007"}],"featureId":"VAR_045257","alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"in LFS; germline mutation; dbSNP:rs878854074","featureCrossReferences":[{"database":"dbSNP","id":"rs878854074"}],"featureId":"VAR_045258","alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005987","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882027","featureCrossReferences":[{"database":"dbSNP","id":"rs730882027"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"}],"featureId":"VAR_033038","alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045259","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045260","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045261","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045262","alternativeSequence":{"originalSequence":"L","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045263","alternativeSequence":{"originalSequence":"L","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912653","featureCrossReferences":[{"database":"dbSNP","id":"rs121912653"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1978757"}],"featureId":"VAR_005988","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045264","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045265","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045266","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525465","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525465"}],"featureId":"VAR_045267","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047193","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045268","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045859","alternativeSequence":{"originalSequence":"I","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045269","alternativeSequence":{"originalSequence":"I","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045270","alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045271","alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_017908","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1330865474","featureCrossReferences":[{"database":"dbSNP","id":"rs1330865474"}],"featureId":"VAR_045272","alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_017909","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs746601313","featureCrossReferences":[{"database":"dbSNP","id":"rs746601313"}],"featureId":"VAR_045273","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519995","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519995"}],"featureId":"VAR_045274","alternativeSequence":{"originalSequence":"I","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045275","alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876659675","featureCrossReferences":[{"database":"dbSNP","id":"rs876659675"}],"featureId":"VAR_045276","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876659675","featureCrossReferences":[{"database":"dbSNP","id":"rs876659675"}],"featureId":"VAR_045277","alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876659675","featureCrossReferences":[{"database":"dbSNP","id":"rs876659675"}],"featureId":"VAR_045278","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045279","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_045280","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045281","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045282","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045283","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005989","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934577","featureCrossReferences":[{"database":"dbSNP","id":"rs28934577"}],"featureId":"VAR_045284","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs28934577","featureCrossReferences":[{"database":"dbSNP","id":"rs28934577"}],"featureId":"VAR_045285","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045286","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045287","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_005990","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1060501201","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501201"}],"featureId":"VAR_045288","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912652","featureCrossReferences":[{"database":"dbSNP","id":"rs121912652"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1978757"}],"featureId":"VAR_005991","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045860","alternativeSequence":{"originalSequence":"E","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045289","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045290","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047194","alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045291","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs745425759","featureCrossReferences":[{"database":"dbSNP","id":"rs745425759"}],"featureId":"VAR_045292","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045293","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045294","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045861","alternativeSequence":{"originalSequence":"D","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045862","alternativeSequence":{"originalSequence":"D","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045295","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"}],"featureId":"VAR_033039","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045296","alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045297","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045298","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045299","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045300","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876658916","featureCrossReferences":[{"database":"dbSNP","id":"rs876658916"}],"featureId":"VAR_045301","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045302","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045303","alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045304","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045305","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045306","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047195","alternativeSequence":{"originalSequence":"GN","alternativeSequences":["PD"]}},{"type":"Natural variant","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs200579969","featureCrossReferences":[{"database":"dbSNP","id":"rs200579969"}],"featureId":"VAR_045307","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047196","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045863","alternativeSequence":{"originalSequence":"G","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs200579969","featureCrossReferences":[{"database":"dbSNP","id":"rs200579969"}],"featureId":"VAR_045308","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1131691025","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691025"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.23"}],"featureId":"VAR_045309","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs72661119","featureCrossReferences":[{"database":"dbSNP","id":"rs72661119"}],"featureId":"VAR_045310","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045311","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045312","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045313","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045314","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045315","alternativeSequence":{"originalSequence":"L","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1555525353","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525353"}],"featureId":"VAR_045316","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045317","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045318","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045319","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045320","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs879253942","featureCrossReferences":[{"database":"dbSNP","id":"rs879253942"}],"featureId":"VAR_045321","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045322","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047197","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045323","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs193920774","featureCrossReferences":[{"database":"dbSNP","id":"rs193920774"}],"featureId":"VAR_045324","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519990","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519990"}],"featureId":"VAR_045325","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs193920774","featureCrossReferences":[{"database":"dbSNP","id":"rs193920774"}],"featureId":"VAR_045326","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045327","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045328","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780075","featureCrossReferences":[{"database":"dbSNP","id":"rs587780075"}],"featureId":"VAR_045329","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587780075","featureCrossReferences":[{"database":"dbSNP","id":"rs587780075"}],"featureId":"VAR_045330","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs55832599","featureCrossReferences":[{"database":"dbSNP","id":"rs55832599"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_036507","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045864","alternativeSequence":{"originalSequence":"N","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045331","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045332","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045333","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045334","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045335","alternativeSequence":{"originalSequence":"N","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045336","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045337","alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047198","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045338","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045339","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045340","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519986","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519986"}],"featureId":"VAR_045341","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519988","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519988"}],"featureId":"VAR_045342","alternativeSequence":{"originalSequence":"F","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519987","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519987"}],"featureId":"VAR_045343","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519986","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519986"}],"featureId":"VAR_045344","alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519988","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519988"}],"featureId":"VAR_045345","alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045346","alternativeSequence":{"originalSequence":"F","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045347","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045348","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045349","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1060501191","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501191"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_036508","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045865","alternativeSequence":{"originalSequence":"E","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045350","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045866","alternativeSequence":{"originalSequence":"E","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_047199","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_045351","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876660333","featureCrossReferences":[{"database":"dbSNP","id":"rs876660333"}],"featureId":"VAR_045352","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876660333","featureCrossReferences":[{"database":"dbSNP","id":"rs876660333"}],"featureId":"VAR_045353","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912657","featureCrossReferences":[{"database":"dbSNP","id":"rs121912657"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1737852"}],"featureId":"VAR_005992","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912657","featureCrossReferences":[{"database":"dbSNP","id":"rs121912657"}],"featureId":"VAR_045354","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121913343","featureCrossReferences":[{"database":"dbSNP","id":"rs121913343"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224074"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887414"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9450901"}],"featureId":"VAR_005993","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_005994","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; does not induce SNAI1 degradation; dbSNP:rs28934576","featureCrossReferences":[{"database":"dbSNP","id":"rs28934576"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1394225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1565144"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1699228"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1868473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20385133"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7682763"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.14"}],"featureId":"VAR_005995","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934576","featureCrossReferences":[{"database":"dbSNP","id":"rs28934576"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_036509","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045867","alternativeSequence":{"originalSequence":"R","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs28934576","featureCrossReferences":[{"database":"dbSNP","id":"rs28934576"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27657329"}],"featureId":"VAR_045355","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045356","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121913343","featureCrossReferences":[{"database":"dbSNP","id":"rs121913343"}],"featureId":"VAR_045357","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045868","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520006","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520006"}],"featureId":"VAR_045358","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520006","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520006"}],"featureId":"VAR_045359","alternativeSequence":{"originalSequence":"V","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520005","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520005"}],"featureId":"VAR_005997","alternativeSequence":{"originalSequence":"V","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520006","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520006"}],"featureId":"VAR_047200","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045360","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057520005","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520005"}],"featureId":"VAR_045361","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs863224451","featureCrossReferences":[{"database":"dbSNP","id":"rs863224451"}],"featureId":"VAR_045362","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045363","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519983","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519983"}],"featureId":"VAR_045364","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs863224451","featureCrossReferences":[{"database":"dbSNP","id":"rs863224451"}],"featureId":"VAR_045365","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525279","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525279"}],"featureId":"VAR_005999","alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs863224451","featureCrossReferences":[{"database":"dbSNP","id":"rs863224451"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887414"}],"featureId":"VAR_005998","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786202082","featureCrossReferences":[{"database":"dbSNP","id":"rs786202082"}],"featureId":"VAR_045366","alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786202082","featureCrossReferences":[{"database":"dbSNP","id":"rs786202082"}],"featureId":"VAR_045367","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1131691029","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691029"}],"featureId":"VAR_045368","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045369","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045370","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045371","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs763098116","featureCrossReferences":[{"database":"dbSNP","id":"rs763098116"}],"featureId":"VAR_045372","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064795369","featureCrossReferences":[{"database":"dbSNP","id":"rs1064795369"}],"featureId":"VAR_006000","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064795369","featureCrossReferences":[{"database":"dbSNP","id":"rs1064795369"}],"featureId":"VAR_045373","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045374","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047201","alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs763098116","featureCrossReferences":[{"database":"dbSNP","id":"rs763098116"}],"featureId":"VAR_045375","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs17849781","featureCrossReferences":[{"database":"dbSNP","id":"rs17849781"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_006001","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045869","alternativeSequence":{"originalSequence":"P","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876659802","featureCrossReferences":[{"database":"dbSNP","id":"rs876659802"}],"featureId":"VAR_006002","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs876659802","featureCrossReferences":[{"database":"dbSNP","id":"rs876659802"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2263646"}],"featureId":"VAR_006003","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876659802","featureCrossReferences":[{"database":"dbSNP","id":"rs876659802"}],"featureId":"VAR_045376","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs17849781","featureCrossReferences":[{"database":"dbSNP","id":"rs17849781"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2263646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9450901"}],"featureId":"VAR_006004","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs17849781","featureCrossReferences":[{"database":"dbSNP","id":"rs17849781"}],"featureId":"VAR_006005","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064793881","featureCrossReferences":[{"database":"dbSNP","id":"rs1064793881"}],"featureId":"VAR_006006","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525248","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525248"}],"featureId":"VAR_045377","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045378","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045379","alternativeSequence":{"originalSequence":"G","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs753660142","featureCrossReferences":[{"database":"dbSNP","id":"rs753660142"}],"featureId":"VAR_045380","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912660","featureCrossReferences":[{"database":"dbSNP","id":"rs121912660"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_006008","alternativeSequence":{"originalSequence":"R","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; no effect on interaction with CCAR2; dbSNP:rs121912660","featureCrossReferences":[{"database":"dbSNP","id":"rs121912660"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1694291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25732823"}],"featureId":"VAR_006007","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045381","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045382","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912660","featureCrossReferences":[{"database":"dbSNP","id":"rs121912660"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1631151"}],"featureId":"VAR_006009","alternativeSequence":{"originalSequence":"R","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047203","alternativeSequence":{"originalSequence":"DR","alternativeSequences":["EW"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587781525","featureCrossReferences":[{"database":"dbSNP","id":"rs587781525"}],"featureId":"VAR_006010","alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519984","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519984"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1459726"}],"featureId":"VAR_006011","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587781525","featureCrossReferences":[{"database":"dbSNP","id":"rs587781525"}],"featureId":"VAR_006012","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs764146326","featureCrossReferences":[{"database":"dbSNP","id":"rs764146326"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_006013","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs764146326","featureCrossReferences":[{"database":"dbSNP","id":"rs764146326"}],"featureId":"VAR_047202","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045870","alternativeSequence":{"originalSequence":"D","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587781525","featureCrossReferences":[{"database":"dbSNP","id":"rs587781525"}],"featureId":"VAR_006014","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs764146326","featureCrossReferences":[{"database":"dbSNP","id":"rs764146326"}],"featureId":"VAR_045383","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934574","featureCrossReferences":[{"database":"dbSNP","id":"rs28934574"}],"featureId":"VAR_045384","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045385","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882008","featureCrossReferences":[{"database":"dbSNP","id":"rs730882008"}],"featureId":"VAR_006015","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs730882008","featureCrossReferences":[{"database":"dbSNP","id":"rs730882008"}],"featureId":"VAR_045386","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs730882008","featureCrossReferences":[{"database":"dbSNP","id":"rs730882008"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18453682"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.22"}],"featureId":"VAR_045387","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; dbSNP:rs28934574","featureCrossReferences":[{"database":"dbSNP","id":"rs28934574"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20385133"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8829627"}],"featureId":"VAR_006016","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs149633775","featureCrossReferences":[{"database":"dbSNP","id":"rs149633775"}],"featureId":"VAR_006017","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_006018","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs371409680","featureCrossReferences":[{"database":"dbSNP","id":"rs371409680"}],"featureId":"VAR_006019","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045388","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_006020","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs149633775","featureCrossReferences":[{"database":"dbSNP","id":"rs149633775"}],"featureId":"VAR_045389","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"}],"featureId":"VAR_006021","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs863224685","featureCrossReferences":[{"database":"dbSNP","id":"rs863224685"}],"featureId":"VAR_045390","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045391","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1204379654","featureCrossReferences":[{"database":"dbSNP","id":"rs1204379654"}],"featureId":"VAR_006022","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045392","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045393","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045394","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs112431538","featureCrossReferences":[{"database":"dbSNP","id":"rs112431538"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1459726"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1694291"}],"featureId":"VAR_006023","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_006024","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912667","featureCrossReferences":[{"database":"dbSNP","id":"rs121912667"}],"featureId":"VAR_006025","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1057519985","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519985"}],"featureId":"VAR_006026","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_006027","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519985","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519985"}],"featureId":"VAR_006028","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201059","featureCrossReferences":[{"database":"dbSNP","id":"rs786201059"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11023613"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8316628"}],"featureId":"VAR_006029","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045871","alternativeSequence":{"originalSequence":"E","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs786201059","featureCrossReferences":[{"database":"dbSNP","id":"rs786201059"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8829627"}],"featureId":"VAR_006030","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1057519985","featureCrossReferences":[{"database":"dbSNP","id":"rs1057519985"}],"featureId":"VAR_045395","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047204","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs748891343","featureCrossReferences":[{"database":"dbSNP","id":"rs748891343"}],"featureId":"VAR_045396","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045397","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782006","featureCrossReferences":[{"database":"dbSNP","id":"rs587782006"}],"featureId":"VAR_045398","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045399","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045400","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045401","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045402","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045403","alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045404","alternativeSequence":{"originalSequence":"N","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045405","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045406","alternativeSequence":{"originalSequence":"L","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045407","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045408","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525154","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525154"}],"featureId":"VAR_045409","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs770374782","featureCrossReferences":[{"database":"dbSNP","id":"rs770374782"}],"featureId":"VAR_045410","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs55819519","featureCrossReferences":[{"database":"dbSNP","id":"rs55819519"}],"featureId":"VAR_045411","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_045412","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525126","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525126"}],"featureId":"VAR_045413","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045414","alternativeSequence":{"originalSequence":"K","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs372613518","featureCrossReferences":[{"database":"dbSNP","id":"rs372613518"}],"featureId":"VAR_045415","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047205","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs781490101","featureCrossReferences":[{"database":"dbSNP","id":"rs781490101"}],"featureId":"VAR_045416","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045417","alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045418","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045872","alternativeSequence":{"originalSequence":"K","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs121912663","featureCrossReferences":[{"database":"dbSNP","id":"rs121912663"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10484981"}],"featureId":"VAR_015819","alternativeSequence":{"originalSequence":"K","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045419","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045420","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912663","featureCrossReferences":[{"database":"dbSNP","id":"rs121912663"}],"featureId":"VAR_045421","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045422","alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045423","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587780076","featureCrossReferences":[{"database":"dbSNP","id":"rs587780076"}],"featureId":"VAR_045424","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045425","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587780076","featureCrossReferences":[{"database":"dbSNP","id":"rs587780076"}],"featureId":"VAR_045426","alternativeSequence":{"originalSequence":"G","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045427","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1305324490","featureCrossReferences":[{"database":"dbSNP","id":"rs1305324490"}],"featureId":"VAR_045428","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045429","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047206","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045430","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045431","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045432","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs751713111","featureCrossReferences":[{"database":"dbSNP","id":"rs751713111"}],"featureId":"VAR_045433","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs751713111","featureCrossReferences":[{"database":"dbSNP","id":"rs751713111"}],"featureId":"VAR_045434","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1131691006","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691006"}],"featureId":"VAR_045435","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045873","alternativeSequence":{"originalSequence":"H","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045436","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_047207","alternativeSequence":{"originalSequence":"H","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045437","alternativeSequence":{"originalSequence":"H","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_006031","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045438","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs483352696","featureCrossReferences":[{"database":"dbSNP","id":"rs483352696"}],"featureId":"VAR_045439","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs672601296","featureCrossReferences":[{"database":"dbSNP","id":"rs672601296"}],"featureId":"VAR_045440","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045441","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045442","alternativeSequence":{"originalSequence":"H","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045443","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876659477","featureCrossReferences":[{"database":"dbSNP","id":"rs876659477"}],"featureId":"VAR_045444","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045445","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045446","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045447","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs201744589","featureCrossReferences":[{"database":"dbSNP","id":"rs201744589"}],"featureId":"VAR_045448","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs201744589","featureCrossReferences":[{"database":"dbSNP","id":"rs201744589"}],"featureId":"VAR_045449","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045450","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045451","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045452","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045453","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045454","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045455","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs909643864","featureCrossReferences":[{"database":"dbSNP","id":"rs909643864"}],"featureId":"VAR_045456","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_006032","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045457","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045458","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525067","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525067"}],"featureId":"VAR_006033","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045459","alternativeSequence":{"originalSequence":"P","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045460","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047208","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045461","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1060501202","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501202"}],"featureId":"VAR_006034","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs863224686","featureCrossReferences":[{"database":"dbSNP","id":"rs863224686"}],"featureId":"VAR_045462","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_006035","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045463","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045464","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs876658714","featureCrossReferences":[{"database":"dbSNP","id":"rs876658714"}],"featureId":"VAR_045465","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045466","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs587782654","featureCrossReferences":[{"database":"dbSNP","id":"rs587782654"}],"featureId":"VAR_045467","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045468","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045469","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047209","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045470","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation","featureId":"VAR_045471","alternativeSequence":{"originalSequence":"K","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; loss of nuclear localization","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10551826"}],"featureId":"VAR_045472","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045473","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045474","alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in a sporadic cancer; somatic mutation","featureId":"VAR_045475","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1048095040","featureCrossReferences":[{"database":"dbSNP","id":"rs1048095040"}],"featureId":"VAR_006036","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045476","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045477","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_006037","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045478","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045479","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045480","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1555525012","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525012"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.14"}],"featureId":"VAR_006038","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045481","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045482","alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555525007","featureCrossReferences":[{"database":"dbSNP","id":"rs1555525007"}],"featureId":"VAR_045483","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045484","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs56184981","featureCrossReferences":[{"database":"dbSNP","id":"rs56184981"}],"featureId":"VAR_045485","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs56184981","featureCrossReferences":[{"database":"dbSNP","id":"rs56184981"}],"featureId":"VAR_045486","alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045487","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs145151284","featureCrossReferences":[{"database":"dbSNP","id":"rs145151284"}],"featureId":"VAR_045488","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045489","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045490","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045491","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1367492395","featureCrossReferences":[{"database":"dbSNP","id":"rs1367492395"}],"featureId":"VAR_045492","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs751440465","featureCrossReferences":[{"database":"dbSNP","id":"rs751440465"}],"featureId":"VAR_045493","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045494","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045495","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045496","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1555524979","featureCrossReferences":[{"database":"dbSNP","id":"rs1555524979"}],"featureId":"VAR_045497","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs772773208","featureCrossReferences":[{"database":"dbSNP","id":"rs772773208"}],"featureId":"VAR_045498","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"in a kidney cancer with no family history; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs1060501199","featureCrossReferences":[{"database":"dbSNP","id":"rs1060501199"}],"featureId":"VAR_045499","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs764735889","featureCrossReferences":[{"database":"dbSNP","id":"rs764735889"}],"featureId":"VAR_045500","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047210","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045501","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1159579789","featureCrossReferences":[{"database":"dbSNP","id":"rs1159579789"}],"featureId":"VAR_045502","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1555524975","featureCrossReferences":[{"database":"dbSNP","id":"rs1555524975"}],"featureId":"VAR_045503","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045504","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045505","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045506","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045507","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"in kidney cancer; germline mutation","featureId":"VAR_045508","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045509","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045510","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045511","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045874","alternativeSequence":{"originalSequence":"L","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045512","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045513","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045514","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1432281680","featureCrossReferences":[{"database":"dbSNP","id":"rs1432281680"}],"featureId":"VAR_047211","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045515","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions","featureId":"VAR_045875","alternativeSequence":{"originalSequence":"D","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045516","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045517","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045518","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"in LFS; germline mutation; dbSNP:rs121912659","featureCrossReferences":[{"database":"dbSNP","id":"rs121912659"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1565144"}],"featureId":"VAR_006039","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045519","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045520","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045521","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045522","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045523","alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045524","alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs969930693","featureCrossReferences":[{"database":"dbSNP","id":"rs969930693"}],"featureId":"VAR_045525","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045526","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045527","alternativeSequence":{"originalSequence":"L","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047212","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045528","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs11575996","featureCrossReferences":[{"database":"dbSNP","id":"rs11575996"}],"featureId":"VAR_045529","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045530","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs1064795056","featureCrossReferences":[{"database":"dbSNP","id":"rs1064795056"}],"featureId":"VAR_045531","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045532","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_006040","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs730882028","featureCrossReferences":[{"database":"dbSNP","id":"rs730882028"}],"featureId":"VAR_045533","alternativeSequence":{"originalSequence":"G","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045534","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs771939956","featureCrossReferences":[{"database":"dbSNP","id":"rs771939956"}],"featureId":"VAR_045535","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045536","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs587782529","featureCrossReferences":[{"database":"dbSNP","id":"rs587782529"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36108750"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9452042"}],"featureId":"VAR_006041","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in sporadic cancers; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs121912664","featureCrossReferences":[{"database":"dbSNP","id":"rs121912664"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11481490"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36108750"}],"featureId":"VAR_035016","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs121912664","featureCrossReferences":[{"database":"dbSNP","id":"rs121912664"}],"featureId":"VAR_045537","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs121912664","featureCrossReferences":[{"database":"dbSNP","id":"rs121912664"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36108750"}],"featureId":"VAR_045538","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045539","alternativeSequence":{"originalSequence":"F","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs150293825","featureCrossReferences":[{"database":"dbSNP","id":"rs150293825"}],"featureId":"VAR_045540","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs17882252","featureCrossReferences":[{"database":"dbSNP","id":"rs17882252"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"}],"featureId":"VAR_022316","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs17882252","featureCrossReferences":[{"database":"dbSNP","id":"rs17882252"}],"featureId":"VAR_045541","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045542","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045543","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs375338359","featureCrossReferences":[{"database":"dbSNP","id":"rs375338359"}],"featureId":"VAR_045544","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs375338359","featureCrossReferences":[{"database":"dbSNP","id":"rs375338359"}],"featureId":"VAR_047213","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045545","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"in LFS; germline mutation and in a sporadic cancer; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs121912662","featureCrossReferences":[{"database":"dbSNP","id":"rs121912662"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36108750"}],"featureId":"VAR_045546","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045547","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045548","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045549","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation","featureId":"VAR_045550","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045551","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045552","alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045553","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045554","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045555","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045556","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs755394212","featureCrossReferences":[{"database":"dbSNP","id":"rs755394212"}],"featureId":"VAR_045557","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs752142489","featureCrossReferences":[{"database":"dbSNP","id":"rs752142489"}],"featureId":"VAR_047214","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045558","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045559","alternativeSequence":{"originalSequence":"G","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045560","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs587782237","featureCrossReferences":[{"database":"dbSNP","id":"rs587782237"}],"featureId":"VAR_045561","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"in dbSNP:rs35993958","featureCrossReferences":[{"database":"dbSNP","id":"rs35993958"}],"featureId":"VAR_045562","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs35993958","featureCrossReferences":[{"database":"dbSNP","id":"rs35993958"}],"featureId":"VAR_045563","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs876660285","featureCrossReferences":[{"database":"dbSNP","id":"rs876660285"}],"featureId":"VAR_045564","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045565","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045566","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045567","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_047215","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs267605075","featureCrossReferences":[{"database":"dbSNP","id":"rs267605075"}],"featureId":"VAR_045568","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs17881470","featureCrossReferences":[{"database":"dbSNP","id":"rs17881470"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"}],"featureId":"VAR_022317","alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045569","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045570","alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045571","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"in sporadic cancers; somatic mutation; dbSNP:rs863224682","featureCrossReferences":[{"database":"dbSNP","id":"rs863224682"}],"featureId":"VAR_045572","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs1555524094","featureCrossReferences":[{"database":"dbSNP","id":"rs1555524094"}],"featureId":"VAR_045573","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation; dbSNP:rs587783064","featureCrossReferences":[{"database":"dbSNP","id":"rs587783064"}],"featureId":"VAR_045574","alternativeSequence":{"originalSequence":"G","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"in a sporadic cancer; somatic mutation","featureId":"VAR_045575","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"Loss of interaction with PPP2R5C, PPP2CAANDPPP2R1A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17967874"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"No effect on interaction with MDM2 and increase in protein levels after DNA damage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Abolishes phosphorylation site. Abolishes increase in protein levels after DNA damage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Constitutively increased TP53 protein levels.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Loss of interaction with MDM2, leading to constitutively increased TP53 protein levels.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570149"}],"alternativeSequence":{"originalSequence":"LW","alternativeSequences":["QS"]}},{"type":"Mutagenesis","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Abolishes ubiquitination by MUL1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21597459"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Abolishes phosphorylation by MAPKAPK5.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17254968"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Abolishes phosphorylation by DYRK2 and HIPK2 and acetylation of K-382 by CREBBP.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11740489"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16219768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17349958"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Alters interaction with WWOX.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11740489"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16219768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17349958"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Blocks phosphorylation by TAF1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053879"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Abolishes strongly phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Inhibits slightly its transcriptional activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Does not induce SNAI1 degradation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20385133"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Abolishes phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Inhibits strongly its transcriptional activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Inhibits strongly its transcriptional activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20959462"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"Abolishes polyubiquitination by MKRN1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19536131"}],"alternativeSequence":{"originalSequence":"KK","alternativeSequences":["RR"]}},{"type":"Mutagenesis","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"Loss of nuclear localization; when associated with A-320 and A-321.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2156209"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Loss of nuclear localization; when associated with A-319 and A-321.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2156209"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Loss of nuclear localization; when associated with A-319 and A-320.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2156209"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Reduced methylation by PRMT5. Reduced nuclear localization. Decreased binding to promoters of target genes. Reduced transcriptional activity. Decrease in cell cycle arrest.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011621"}],"alternativeSequence":{"originalSequence":"RGRER","alternativeSequences":["KGKEK"]}},{"type":"Mutagenesis","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"Abolishes binding to USP7.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16402859"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"Abolishes binding to USP7.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16402859"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"Abolishes binding to USP7.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16402859"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"Induces a decrease in methylation by SMYD2.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17108971"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"Induces a decrease in protein stabilization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15525938"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Abolishes dimethylation by EHMT1 and EHMT2.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20118233"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"Mimics acetylation, leading to increased stability.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29474172"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"Decreased acetylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29474172"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"Abolishes acetylation by CREBBP.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10884347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11740489"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17707234"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20870725"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"Abolishes monomethylation by KMT5A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10884347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11740489"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17707234"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20870725"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Abolishes S-315 phosphorylation by CDK2/cyclin A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10884347"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"Reduced SUMO1 conjugation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10884347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11124955"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"Abolishes SUMO1 conjugation, in vitro and in vivo.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11124955"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.37"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"No effect SUMO1 conjugation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11124955"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"Abolishes SUMO1 conjugation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11124955"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"Mimics phosphorylation; promotes ability to undergo liquid-liquid phase separation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35618207"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"Abolished ability to undergo liquid-liquid phase separation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31953488"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Helix","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5HOU"}]},{"type":"Turn","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5HOU"}]},{"type":"Helix","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5S"}]},{"type":"Helix","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5HPD"}]},{"type":"Beta strand","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2L14"}]},{"type":"Helix","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2B3G"}]},{"type":"Helix","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2B3G"}]},{"type":"Helix","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2B3G"}]},{"type":"Helix","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6SL6"}]},{"type":"Helix","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4MZI"}]},{"type":"Turn","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BUA"}]},{"type":"Beta strand","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Turn","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Helix","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Helix","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Helix","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8GCR"}]},{"type":"Helix","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4KVP"}]},{"type":"Beta strand","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GGC"}]},{"type":"Beta strand","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Turn","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Helix","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Turn","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2FEJ"}]},{"type":"Beta strand","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Helix","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D07"}]},{"type":"Turn","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Beta strand","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2ADY"}]},{"type":"Beta strand","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Helix","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3D06"}]},{"type":"Helix","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4HJE"}]},{"type":"Helix","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3Q01"}]},{"type":"Beta strand","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8UQR"}]},{"type":"Helix","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8UQR"}]},{"type":"Turn","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7BWN"}]},{"type":"Helix","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1YC5"}]},{"type":"Helix","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1H26"}]},{"type":"Helix","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MHC"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0877","category":"Coding sequence diversity","name":"Alternative promoter usage"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0435","category":"Disease","name":"Li-Fraumeni syndrome"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1210","category":"Biological process","name":"Necrosis"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0043","category":"Disease","name":"Tumor suppressor"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"4006916","citationType":"journal article","authors":["Zakut-Houri R.","Bienz-Tadmor B.","Givol D.","Oren M."],"citationCrossReferences":[{"database":"PubMed","id":"4006916"},{"database":"DOI","id":"10.1002/j.1460-2075.1985.tb03768.x"}],"title":"Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.","publicationDate":"1985","journal":"EMBO J.","firstPage":"1251","lastPage":"1255","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"2946935","citationType":"journal article","authors":["Lamb P.","Crawford L."],"citationCrossReferences":[{"database":"PubMed","id":"2946935"},{"database":"DOI","id":"10.1128/mcb.6.5.1379-1385.1986"}],"title":"Characterization of the human p53 gene.","publicationDate":"1986","journal":"Mol. Cell. Biol.","firstPage":"1379","lastPage":"1385","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)","VARIANT GLY-76"]},{"referenceNumber":3,"citation":{"id":"3894933","citationType":"journal article","authors":["Harlow E.","Williamson N.M.","Ralston R.","Helfman D.M.","Adams T.E."],"citationCrossReferences":[{"database":"PubMed","id":"3894933"},{"database":"DOI","id":"10.1128/mcb.5.7.1601-1610.1985"}],"title":"Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.","publicationDate":"1985","journal":"Mol. Cell. Biol.","firstPage":"1601","lastPage":"1610","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"3025664","citationType":"journal article","authors":["Harris N.","Brill E.","Shohat O.","Prokocimer M.","Wolf D.","Arai N.","Rotter V."],"citationCrossReferences":[{"database":"PubMed","id":"3025664"},{"database":"DOI","id":"10.1128/mcb.6.12.4650-4656.1986"}],"title":"Molecular basis for heterogeneity of the human p53 protein.","publicationDate":"1986","journal":"Mol. Cell. Biol.","firstPage":"4650","lastPage":"4656","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":5,"citation":{"id":"2905688","citationType":"journal article","authors":["Buchman V.L.","Chumakov P.M.","Ninkina N.N.","Samarina O.P.","Georgiev G.P."],"citationCrossReferences":[{"database":"PubMed","id":"2905688"},{"database":"DOI","id":"10.1016/0378-1119(88)90196-5"}],"title":"A variation in the structure of the protein-coding region of the human p53 gene.","publicationDate":"1988","journal":"Gene","firstPage":"245","lastPage":"252","volume":"70"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"1915267","citationType":"journal article","authors":["Farrell P.J.","Allan G.","Shanahan F.","Vousden K.H.","Crook T."],"citationCrossReferences":[{"database":"PubMed","id":"1915267"},{"database":"DOI","id":"10.1002/j.1460-2075.1991.tb07837.x"}],"title":"p53 is frequently mutated in Burkitt's lymphoma cell lines.","publicationDate":"1991","journal":"EMBO J.","firstPage":"2879","lastPage":"2887","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANTS SPORADIC CANCERS"]},{"referenceNumber":7,"citation":{"id":"8316628","citationType":"journal article","authors":["Allalunis-Turner M.J.","Barron G.M.","Day R.S. III","Dobler K.D.","Mirzayans R."],"citationCrossReferences":[{"database":"PubMed","id":"8316628"},{"database":"DOI","id":"10.2307/3578196"}],"title":"Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs.","publicationDate":"1993","journal":"Radiat. Res.","firstPage":"349","lastPage":"354","volume":"134"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT LYS-286"]},{"referenceNumber":8,"citation":{"id":"11058590","citationType":"journal article","authors":["Chang N.-S.","Pratt N.","Heath J.","Schultz L.","Sleve D.","Carey G.B.","Zevotek N."],"citationCrossReferences":[{"database":"PubMed","id":"11058590"},{"database":"DOI","id":"10.1074/jbc.m007140200"}],"title":"Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"3361","lastPage":"3370","volume":"276"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","INTERACTION WITH WWOX"]},{"referenceNumber":9,"citation":{"id":"16131611","citationType":"journal article","authors":["Bourdon J.C.","Fernandes K.","Murray-Zmijewski F.","Liu G.","Diot A.","Xirodimas D.P.","Saville M.K.","Lane D.P."],"citationCrossReferences":[{"database":"PubMed","id":"16131611"},{"database":"DOI","id":"10.1101/gad.1339905"}],"title":"p53 isoforms can regulate p53 transcriptional activity.","publicationDate":"2005","journal":"Genes Dev.","firstPage":"2122","lastPage":"2137","volume":"19"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 7; 8 AND 9)","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","ALTERNATIVE PROMOTER USAGE","ALTERNATIVE SPLICING","INDUCTION","VARIANT ARG-72"],"referenceComments":[{"value":"Colon","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"CI-8C1T8BUL7KG2A","citationType":"submission","authors":["Chumakov P.M.","Almazov V.P.","Jenkins J.R."],"publicationDate":"JUN-1991","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":11,"citation":{"id":"CI-9M3D9J7U2MDR4","citationType":"submission","authors":["Rozemuller E.H.","Tilanus M.G.J."],"title":"P53 genomic sequence. Corrections and polymorphism.","publicationDate":"MAR-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":12,"citation":{"id":"CI-86ALM2TFFQ300","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"NOV-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS SER-47; LYS-339 AND ALA-366"]},{"referenceNumber":13,"citation":{"id":"11023613","citationType":"journal article","authors":["Anderson C.W.","Allalunis-Turner M.J."],"citationCrossReferences":[{"database":"PubMed","id":"11023613"},{"database":"DOI","id":"10.1667/0033-7587(2000)154[0473:htftmg]2.0.co;2"}],"title":"Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8.","publicationDate":"2000","journal":"Radiat. Res.","firstPage":"473","lastPage":"476","volume":"154"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT LYS-286"]},{"referenceNumber":14,"citation":{"id":"CI-AMPIBVI7IO3G4","citationType":"submission","authors":["Azuma K.","Shichijo S.","Itoh K."],"title":"Identification of a tumor-rejection antigen recognized by HLA-B46 restricted CTL.","publicationDate":"MAR-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANTS HIS-273 AND SER-309"]},{"referenceNumber":15,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","VARIANT ARG-72"]},{"referenceNumber":16,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":17,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANT ARG-72"]},{"referenceNumber":18,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","VARIANT ALA-278"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"14660794","citationType":"journal article","authors":["Kanashiro C.A.","Schally A.V.","Groot K.","Armatis P.","Bernardino A.L.","Varga J.L."],"citationCrossReferences":[{"database":"PubMed","id":"14660794"},{"database":"DOI","id":"10.1073/pnas.2536558100"}],"title":"Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.","publicationDate":"2003","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15836","lastPage":"15841","volume":"100"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-379 (ISOFORM 1)","VARIANTS ASN-139 AND PRO-155"],"referenceComments":[{"value":"Lung carcinoma","type":"TISSUE"}]},{"referenceNumber":20,"citation":{"id":"6396087","citationType":"journal article","authors":["Matlashewski G.","Lamb P.","Pim D.","Peacock J.","Crawford L.","Benchimol S."],"citationCrossReferences":[{"database":"PubMed","id":"6396087"},{"database":"DOI","id":"10.1002/j.1460-2075.1984.tb02287.x"}],"title":"Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene.","publicationDate":"1984","journal":"EMBO J.","firstPage":"3257","lastPage":"3262","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 101-393"]},{"referenceNumber":21,"citation":{"id":"CI-668DAA267SUPO","citationType":"submission","authors":["Pan X.L.","Zhang A.H."],"title":"Study on the effect of tumor suppressor gene p53 in arsenism patients.","publicationDate":"SEP-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-185"]},{"referenceNumber":22,"citation":{"id":"CI-D45UV8P9LEPU6","citationType":"submission","authors":["Nimri L.F.","Owais W.","Momani E."],"title":"Detection of P53 gene mutations and serum p53 antibodies associated with cigarette smoking.","publicationDate":"AUG-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 261-298","VARIANT GLN-282"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"CI-ADDS09TRP9ONS","citationType":"submission","authors":["Filippini G.","Soldati G."],"publicationDate":"JUL-1996","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 262-306","VARIANT VAL-262"],"referenceComments":[{"value":"Ovarian adenocarcinoma","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"CI-8626C10E2UR4G","citationType":"submission","authors":["Thompson-Hehir J.","Davies M.P.A.","Green J.A.","Halliwell N.","Joyce K.A.","Salisbury J.","Sibson D.R.","Vergote I.","Walker C."],"title":"Mutation detection utilizing a novel PCR approach for amplification of the p53 gene from microdissected tissue: application to archival tumor samples.","publicationDate":"DEC-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 225-260"],"referenceComments":[{"value":"Glial cell","type":"TISSUE"},{"value":"Glial tumor","type":"TISSUE"}]},{"referenceNumber":25,"citation":{"id":"CI-33DBJ1IU1IEBG","citationType":"submission","authors":["Yavuz A.S.","Farner N.L.","Yavuz S.","Grammer A.C.","Girschick H.J.","Lipsky P.E."],"title":"Bcl6 and P53 gene mutations in tonsillar B cells.","publicationDate":"MAR-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 225-260"]},{"referenceNumber":26,"citation":{"id":"19011621","citationType":"journal article","authors":["Jansson M.","Durant S.T.","Cho E.C.","Sheahan S.","Edelmann M.","Kessler B.","La Thangue N.B."],"citationCrossReferences":[{"database":"PubMed","id":"19011621"},{"database":"DOI","id":"10.1038/ncb1802"}],"title":"Arginine methylation regulates the p53 response.","publicationDate":"2008","journal":"Nat. Cell Biol.","firstPage":"1431","lastPage":"1439","volume":"10"},"referencePositions":["PROTEIN SEQUENCE OF 320-337","SUBUNIT","INTERACTION WITH PRMT5","SUBCELLULAR LOCATION","METHYLATION AT ARG-333; ARG-335 AND ARG-337 BY PRMT5","IDENTIFICATION BY MASS SPECTROMETRY","MUTAGENESIS OF 333-ARG--ARG-337"]},{"referenceNumber":27,"citation":{"id":"CI-B1KJF44ND99KF","citationType":"submission","authors":["Pinto E.M.","Mendonca B.B.","Latronico A.C."],"title":"Allelic variant in intron 9 of TP53 gene.","publicationDate":"APR-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 332-366"]},{"referenceNumber":28,"citation":{"id":"2175676","citationType":"journal article","authors":["Scheffner M.","Werness B.A.","Huibregtse J.M.","Levine A.J.","Howley P.M."],"citationCrossReferences":[{"database":"PubMed","id":"2175676"},{"database":"DOI","id":"10.1016/0092-8674(90)90409-8"}],"title":"The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53.","publicationDate":"1990","journal":"Cell","firstPage":"1129","lastPage":"1136","volume":"63"},"referencePositions":["INTERACTION WITH HUMAN PAPILLOMAVIRUS TYPE 6 AND 11 PROTEIN E6 (MICROBIAL INFECTION)"]},{"referenceNumber":29,"citation":{"id":"2156209","citationType":"journal article","authors":["Addison C.","Jenkins J.R.","Sturzbecher H.-W."],"citationCrossReferences":[{"database":"PubMed","id":"2156209"}],"title":"The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.","publicationDate":"1990","journal":"Oncogene","firstPage":"423","lastPage":"426","volume":"5"},"referencePositions":["NUCLEAR LOCALIZATION SIGNAL","MUTAGENESIS OF LYS-319; LYS-320 AND LYS-321"]},{"referenceNumber":30,"citation":{"id":"2141171","citationType":"journal article","authors":["Bischoff J.R.","Friedman P.N.","Marshak D.R.","Prives C.","Beach D."],"citationCrossReferences":[{"database":"PubMed","id":"2141171"},{"database":"DOI","id":"10.1073/pnas.87.12.4766"}],"title":"Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.","publicationDate":"1990","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4766","lastPage":"4770","volume":"87"},"referencePositions":["PHOSPHORYLATION BY P60/CDC2 AND CYCLIN B/CDC2"]},{"referenceNumber":31,"citation":{"id":"1705009","citationType":"journal article","authors":["Samad A.","Carroll R.B."],"citationCrossReferences":[{"database":"PubMed","id":"1705009"},{"database":"DOI","id":"10.1128/mcb.11.3.1598-1606.1991"}],"title":"The tumor suppressor p53 is bound to RNA by a stable covalent linkage.","publicationDate":"1991","journal":"Mol. Cell. Biol.","firstPage":"1598","lastPage":"1606","volume":"11"},"referencePositions":["PHOSPHORYLATION"]},{"referenceNumber":32,"citation":{"id":"1848668","citationType":"journal article","authors":["Scheidtmann K.H.","Mumby M.C.","Rundell K.","Walter G."],"citationCrossReferences":[{"database":"PubMed","id":"1848668"},{"database":"DOI","id":"10.1128/mcb.11.4.1996-2003.1991"}],"title":"Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.","publicationDate":"1991","journal":"Mol. Cell. Biol.","firstPage":"1996","lastPage":"2003","volume":"11"},"referencePositions":["DEPHOSPHORYLATION BY PP2A"]},{"referenceNumber":33,"citation":{"id":"8632903","citationType":"journal article","authors":["Flaman J.-M.","Waridel F.","Estreicher A.","Vannier A.","Limacher J.-M.","Gilbert D.","Iggo R.","Frebourg T."],"citationCrossReferences":[{"database":"PubMed","id":"8632903"}],"title":"The human tumour suppressor gene p53 is alternatively spliced in normal cells.","publicationDate":"1996","journal":"Oncogene","firstPage":"813","lastPage":"818","volume":"12"},"referencePositions":["ALTERNATIVE SPLICING"]},{"referenceNumber":34,"citation":{"id":"8632915","citationType":"journal article","authors":["Shaw P.","Freeman J.","Bovey R.","Iggo R."],"citationCrossReferences":[{"database":"PubMed","id":"8632915"}],"title":"Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.","publicationDate":"1996","journal":"Oncogene","firstPage":"921","lastPage":"930","volume":"12"},"referencePositions":["GLYCOSYLATION"]},{"referenceNumber":35,"citation":{"id":"9372954","citationType":"journal article","authors":["Ko L.J.","Shieh S.-Y.","Chen X.","Jayaraman L.","Tamai K.","Taya Y.","Prives C.","Pan Z.-Q."],"citationCrossReferences":[{"database":"PubMed","id":"9372954"},{"database":"DOI","id":"10.1128/mcb.17.12.7220"}],"title":"p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.","publicationDate":"1997","journal":"Mol. Cell. Biol.","firstPage":"7220","lastPage":"7229","volume":"17"},"referencePositions":["PHOSPHORYLATION AT SER-33"]},{"referenceNumber":36,"citation":{"id":"9840937","citationType":"journal article","authors":["Schneider E.","Montenarh M.","Wagner P."],"citationCrossReferences":[{"database":"PubMed","id":"9840937"},{"database":"DOI","id":"10.1038/sj.onc.1202504"}],"title":"Regulation of CAK kinase activity by p53.","publicationDate":"1998","journal":"Oncogene","firstPage":"2733","lastPage":"2741","volume":"17"},"referencePositions":["FUNCTION","IDENTIFICATION IN COMPLEX WITH CAK"]},{"referenceNumber":37,"citation":{"id":"CI-A9S7F1JUFAE67","citationType":"journal article","authors":["Gostissa M.","Hengstermann A.","Fogal V.","Sandy P.","Schwarz S.E.","Scheffner M.","Del Sal G."],"title":"Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.","publicationDate":"1999","journal":"EMBO J.","firstPage":"6462","lastPage":"6471","volume":"18"},"referencePositions":["SUMOYLATION AT LYS-386","MUTAGENESIS OF LYS-386"]},{"referenceNumber":38,"citation":{"id":"10606744","citationType":"journal article","authors":["Dumaz N.","Milne D.M.","Meek D.W."],"citationCrossReferences":[{"database":"PubMed","id":"10606744"},{"database":"DOI","id":"10.1016/s0014-5793(99)01647-6"}],"title":"Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.","publicationDate":"1999","journal":"FEBS Lett.","firstPage":"312","lastPage":"316","volume":"463"},"referencePositions":["PHOSPHORYLATION AT THR-18 BY CSNK1D/CK1"]},{"referenceNumber":39,"citation":{"id":"10551826","citationType":"journal article","authors":["Liang S.H.","Clarke M.F."],"citationCrossReferences":[{"database":"PubMed","id":"10551826"},{"database":"DOI","id":"10.1074/jbc.274.46.32699"}],"title":"A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"32699","lastPage":"32703","volume":"274"},"referencePositions":["BIPARTITE NUCLEAR LOCALIZATION SIGNAL","CHARACTERIZATION OF VARIANT ASN-305"]},{"referenceNumber":40,"citation":{"id":"10570149","citationType":"journal article","authors":["Chehab N.H.","Malikzay A.","Stavridi E.S.","Halazonetis T.D."],"citationCrossReferences":[{"database":"PubMed","id":"10570149"},{"database":"DOI","id":"10.1073/pnas.96.24.13777"}],"title":"Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.","publicationDate":"1999","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"13777","lastPage":"13782","volume":"96"},"referencePositions":["PHOSPHORYLATION AT SER-15 AND SER-20","INDUCTION BY DNA DAMAGE","CHARACTERIZATION OF LFS VARIANT HIS-273","MUTAGENESIS OF THR-18; SER-20 AND 22-LEU-TRP-23","SUBCELLULAR LOCATION","INTERACTION WITH PML AND MDM2"]},{"referenceNumber":41,"citation":{"id":"10722742","citationType":"journal article","authors":["Fang S.","Jensen J.P.","Ludwig R.L.","Vousden K.H.","Weissman A.M."],"citationCrossReferences":[{"database":"PubMed","id":"10722742"},{"database":"DOI","id":"10.1074/jbc.275.12.8945"}],"title":"Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"8945","lastPage":"8951","volume":"275"},"referencePositions":["UBIQUITINATION"]},{"referenceNumber":42,"citation":{"id":"10656795","citationType":"journal article","authors":["Abraham J.","Kelly J.","Thibault P.","Benchimol S."],"citationCrossReferences":[{"database":"PubMed","id":"10656795"},{"database":"DOI","id":"10.1006/jmbi.1999.3415"}],"title":"Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry.","publicationDate":"2000","journal":"J. Mol. Biol.","firstPage":"853","lastPage":"864","volume":"295"},"referencePositions":["ACETYLATION AT LYS-373 AND LYS-382"]},{"referenceNumber":43,"citation":{"id":"10884347","citationType":"journal article","authors":["Luciani M.G.","Hutchins J.R.A.","Zheleva D.","Hupp T.R."],"citationCrossReferences":[{"database":"PubMed","id":"10884347"},{"database":"DOI","id":"10.1006/jmbi.2000.3830"}],"title":"The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.","publicationDate":"2000","journal":"J. Mol. Biol.","firstPage":"503","lastPage":"518","volume":"300"},"referencePositions":["PHOSPHORYLATION AT SER-315 AND SER-392 BY CDK2","MUTAGENESIS OF LYS-382; LEU-383 AND PHE-385"]},{"referenceNumber":44,"citation":{"id":"11025664","citationType":"journal article","authors":["Guo A.","Salomoni P.","Luo J.","Shih A.","Zhong S.","Gu W.","Pandolfi P.P."],"citationCrossReferences":[{"database":"PubMed","id":"11025664"},{"database":"DOI","id":"10.1038/35036365"}],"title":"The function of PML in p53-dependent apoptosis.","publicationDate":"2000","journal":"Nat. Cell Biol.","firstPage":"730","lastPage":"736","volume":"2"},"referencePositions":["FUNCTION","INTERACTION WITH PML","SUBCELLULAR LOCATION"]},{"referenceNumber":45,"citation":{"id":"10644996","citationType":"journal article","authors":["Sandy P.","Gostissa M.","Fogal V.","Cecco L.D.","Szalay K.","Rooney R.J.","Schneider C.","Del Sal G."],"citationCrossReferences":[{"database":"PubMed","id":"10644996"},{"database":"DOI","id":"10.1038/sj.onc.1203250"}],"title":"p53 is involved in the p120E4F-mediated growth arrest.","publicationDate":"2000","journal":"Oncogene","firstPage":"188","lastPage":"199","volume":"19"},"referencePositions":["INTERACTION WITH E4F1"]},{"referenceNumber":46,"citation":{"id":"10951572","citationType":"journal article","authors":["Lopez-Borges S.","Lazo P.A."],"citationCrossReferences":[{"database":"PubMed","id":"10951572"},{"database":"DOI","id":"10.1038/sj.onc.1203709"}],"title":"The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.","publicationDate":"2000","journal":"Oncogene","firstPage":"3656","lastPage":"3664","volume":"19"},"referencePositions":["PHOSPHORYLATION AT THR-18"]},{"referenceNumber":47,"citation":{"id":"11554448","citationType":"journal article","authors":["Hainaut P.","Mann K."],"citationCrossReferences":[{"database":"PubMed","id":"11554448"},{"database":"DOI","id":"10.1089/15230860152542961"}],"title":"Zinc binding and redox control of p53 structure and function.","publicationDate":"2001","journal":"Antioxid. Redox Signal.","firstPage":"611","lastPage":"623","volume":"3"},"referencePositions":["REVIEW ON ZINC-BINDING PROPERTIES"]},{"referenceNumber":48,"citation":{"id":"11554766","citationType":"journal article","authors":["Imamura K.","Ogura T.","Kishimoto A.","Kaminishi M.","Esumi H."],"citationCrossReferences":[{"database":"PubMed","id":"11554766"},{"database":"DOI","id":"10.1006/bbrc.2001.5627"}],"title":"Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.","publicationDate":"2001","journal":"Biochem. Biophys. Res. Commun.","firstPage":"562","lastPage":"567","volume":"287"},"referencePositions":["PHOSPHORYLATION AT SER-15"]},{"referenceNumber":49,"citation":{"id":"11672523","citationType":"journal article","authors":["Vaziri H.","Dessain S.K.","Ng Eaton E.","Imai S.","Frye R.A.","Pandita T.K.","Guarente L.","Weinberg R.A."],"citationCrossReferences":[{"database":"PubMed","id":"11672523"},{"database":"DOI","id":"10.1016/s0092-8674(01)00527-x"}],"title":"hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.","publicationDate":"2001","journal":"Cell","firstPage":"149","lastPage":"159","volume":"107"},"referencePositions":["DEACETYLATION AT LYS-382 BY SIRT1"]},{"referenceNumber":50,"citation":{"id":"11007800","citationType":"journal article","authors":["Hong T.M.","Chen J.J.","Peck K.","Yang P.C.","Wu C.W."],"citationCrossReferences":[{"database":"PubMed","id":"11007800"},{"database":"DOI","id":"10.1074/jbc.m008231200"}],"title":"p53 amino acids 339-346 represent the minimal p53 repression domain.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"1510","lastPage":"1515","volume":"276"},"referencePositions":["MINIMAL REPRESSION DOMAIN"]},{"referenceNumber":51,"citation":{"id":"11447225","citationType":"journal article","authors":["Xie S.","Wang Q.","Wu H.","Cogswell J.","Lu L.","Jhanwar-Uniyal M.","Dai W."],"citationCrossReferences":[{"database":"PubMed","id":"11447225"},{"database":"DOI","id":"10.1074/jbc.m104157200"}],"title":"Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"36194","lastPage":"36199","volume":"276"},"referencePositions":["PHOSPHORYLATION AT SER-20 BY PLK3"]},{"referenceNumber":52,"citation":{"id":"11551930","citationType":"journal article","authors":["Xie S.","Wu H.","Wang Q.","Cogswell J.P.","Husain I.","Conn C.","Stambrook P.","Jhanwar-Uniyal M.","Dai W."],"citationCrossReferences":[{"database":"PubMed","id":"11551930"},{"database":"DOI","id":"10.1074/jbc.m106050200"}],"title":"Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"43305","lastPage":"43312","volume":"276"},"referencePositions":["PHOSPHORYLATION AT SER-20 BY PLK3"]},{"referenceNumber":53,"citation":{"id":"11124955","citationType":"journal article","authors":["Rodriguez M.S.","Dargemont C.","Hay R.T."],"citationCrossReferences":[{"database":"PubMed","id":"11124955"},{"database":"DOI","id":"10.1074/jbc.m009476200"}],"title":"SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"12654","lastPage":"12659","volume":"276"},"referencePositions":["SUMOYLATION AT LYS-386","SUBCELLULAR LOCATION","MUTAGENESIS OF PHE-385; LYS-386; THR-387 AND GLU-388"]},{"referenceNumber":54,"citation":{"id":"11546806","citationType":"journal article","authors":["Abe Y.","Matsumoto S.","Wei S.","Nezu K.","Miyoshi A.","Kito K.","Ueda N.","Shigemoto K.","Hitsumoto Y.","Nikawa J.","Enomoto Y."],"citationCrossReferences":[{"database":"PubMed","id":"11546806"},{"database":"DOI","id":"10.1074/jbc.m105669200"}],"title":"Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"44003","lastPage":"44011","volume":"276"},"referencePositions":["PHOSPHORYLATION BY PRPK"]},{"referenceNumber":55,"citation":{"id":"11239457","citationType":"journal article","authors":["Keller D.M.","Zeng X.","Wang Y.","Zhang Q.H.","Kapoor M.","Shu H.","Goodman R.","Lozano G.","Zhao Y.","Lu H."],"citationCrossReferences":[{"database":"PubMed","id":"11239457"},{"database":"DOI","id":"10.1016/s1097-2765(01)00176-9"}],"title":"A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.","publicationDate":"2001","journal":"Mol. Cell","firstPage":"283","lastPage":"292","volume":"7"},"referencePositions":["PHOSPHORYLATION AT SER-392"]},{"referenceNumber":56,"citation":{"id":"12507430","citationType":"journal article","authors":["Hu M.","Li P.","Li M.","Li W.","Yao T.","Wu J.-W.","Gu W.","Cohen R.E.","Shi Y."],"citationCrossReferences":[{"database":"PubMed","id":"12507430"},{"database":"DOI","id":"10.1016/s0092-8674(02)01199-6"}],"title":"Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.","publicationDate":"2002","journal":"Cell","firstPage":"1041","lastPage":"1054","volume":"111"},"referencePositions":["INTERACTION WITH USP7"]},{"referenceNumber":57,"citation":{"id":"11706030","citationType":"journal article","authors":["Tsuji K.","Mizumoto K.","Yamochi T.","Nishimoto I.","Matsuoka M."],"citationCrossReferences":[{"database":"PubMed","id":"11706030"},{"database":"DOI","id":"10.1074/jbc.m108535200"}],"title":"Differential effect of ik3-1/cables on p53- and p73-induced cell death.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"2951","lastPage":"2957","volume":"277"},"referencePositions":["IDENTIFICATION IN A COMPLEX WITH CABLES1 AND TP73"]},{"referenceNumber":58,"citation":{"id":"11925430","citationType":"journal article","authors":["Kim E.-J.","Park J.-S.","Um S.-J."],"citationCrossReferences":[{"database":"PubMed","id":"11925430"},{"database":"DOI","id":"10.1074/jbc.m200153200"}],"title":"Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"32020","lastPage":"32028","volume":"277"},"referencePositions":["INTERACTION WITH HIPK2"]},{"referenceNumber":59,"citation":{"id":"11740489","citationType":"journal article","authors":["Hofmann T.G.","Moeller A.","Sirma H.","Zentgraf H.","Taya Y.","Droege W.","Will H.","Schmitz M.L."],"citationCrossReferences":[{"database":"PubMed","id":"11740489"},{"database":"DOI","id":"10.1038/ncb715"}],"title":"Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.","publicationDate":"2002","journal":"Nat. Cell Biol.","firstPage":"1","lastPage":"10","volume":"4"},"referencePositions":["INTERACTION WITH HIPK2","PHOSPHORYLATION AT SER-46","MUTAGENESIS OF SER-46 AND LYS-382"]},{"referenceNumber":60,"citation":{"id":"11780126","citationType":"journal article","authors":["D'Orazi G.","Cecchinelli B.","Bruno T.","Manni I.","Higashimoto Y.","Saito S.","Gostissa M.","Coen S.","Marchetti A.","Del Sal G.","Piaggio G.","Fanciulli M.","Appella E.","Soddu S."],"citationCrossReferences":[{"database":"PubMed","id":"11780126"},{"database":"DOI","id":"10.1038/ncb714"}],"title":"Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.","publicationDate":"2002","journal":"Nat. Cell Biol.","firstPage":"11","lastPage":"19","volume":"4"},"referencePositions":["INTERACTION WITH HIPK2","PHOSPHORYLATION AT SER-46"]},{"referenceNumber":61,"citation":{"id":"12750254","citationType":"journal article","authors":["Shiseki M.","Nagashima M.","Pedeux R.M.","Kitahama-Shiseki M.","Miura K.","Okamura S.","Onogi H.","Higashimoto Y.","Appella E.","Yokota J.","Harris C.C."],"citationCrossReferences":[{"database":"PubMed","id":"12750254"}],"title":"p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.","publicationDate":"2003","journal":"Cancer Res.","firstPage":"2373","lastPage":"2378","volume":"63"},"referencePositions":["INTERACTION WITH ING4"]},{"referenceNumber":62,"citation":{"id":"12724314","citationType":"journal article","authors":["Wang Y.H.","Tsay Y.G.","Tan B.C.","Lo W.Y.","Lee S.C."],"citationCrossReferences":[{"database":"PubMed","id":"12724314"},{"database":"DOI","id":"10.1074/jbc.m212574200"}],"title":"Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"25568","lastPage":"25576","volume":"278"},"referencePositions":["ACETYLATION AT LYS-305"]},{"referenceNumber":63,"citation":{"id":"12810724","citationType":"journal article","authors":["Louria-Hayon I.","Grossman T.","Sionov R.V.","Alsheich O.","Pandolfi P.P.","Haupt Y."],"citationCrossReferences":[{"database":"PubMed","id":"12810724"},{"database":"DOI","id":"10.1074/jbc.m301264200"}],"title":"The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"33134","lastPage":"33141","volume":"278"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH CHEK2 AND PML","UBIQUITINATION BY MDM2","PHOSPHORYLATION AT SER-20"]},{"referenceNumber":64,"citation":{"id":"12851404","citationType":"journal article","authors":["Tomasini R.","Samir A.A.","Carrier A.","Isnardon D.","Cecchinelli B.","Soddu S.","Malissen B.","Dagorn J.-C.","Iovanna J.L.","Dusetti N.J."],"citationCrossReferences":[{"database":"PubMed","id":"12851404"},{"database":"DOI","id":"10.1074/jbc.m301979200"}],"title":"TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"37722","lastPage":"37729","volume":"278"},"referencePositions":["INTERACTION WITH TP53INP1"]},{"referenceNumber":65,"citation":{"id":"12944468","citationType":"journal article","authors":["O'Keefe K.","Li H.","Zhang Y."],"citationCrossReferences":[{"database":"PubMed","id":"12944468"},{"database":"DOI","id":"10.1128/mcb.23.18.6396-6405.2003"}],"title":"Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"6396","lastPage":"6405","volume":"23"},"referencePositions":["NUCLEOCYTOPLASMIC SHUTTLING","NUCLEAR EXPORT SIGNAL"]},{"referenceNumber":66,"citation":{"id":"12524540","citationType":"journal article","authors":["Bergamaschi D.","Samuels Y.","O'Neil N.J.","Trigiante G.","Crook T.","Hsieh J.-K.","O'Connor D.J.","Zhong S.","Campargue I.","Tomlinson M.L.","Kuwabara P.E.","Lu X."],"citationCrossReferences":[{"database":"PubMed","id":"12524540"},{"database":"DOI","id":"10.1038/ng1070"}],"title":"iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.","publicationDate":"2003","journal":"Nat. Genet.","firstPage":"162","lastPage":"167","volume":"33"},"referencePositions":["FUNCTION","INTERACTION WITH PPP1R13L; PPP1R13B AND TP53BP2"]},{"referenceNumber":67,"citation":{"id":"12702766","citationType":"journal article","authors":["Kondo S.","Lu Y.","Debbas M.","Lin A.W.","Sarosi I.","Itie A.","Wakeham A.","Tuan J.","Saris C.","Elliott G.","Ma W.","Benchimol S.","Lowe S.W.","Mak T.W.","Thukral S.K."],"citationCrossReferences":[{"database":"PubMed","id":"12702766"},{"database":"DOI","id":"10.1073/pnas.0530308100"}],"title":"Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).","publicationDate":"2003","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"5431","lastPage":"5436","volume":"100"},"referencePositions":["INTERACTION WITH HIPK1"]},{"referenceNumber":68,"citation":{"id":"15109303","citationType":"journal article","authors":["Hasan M.K.","Yaguchi T.","Minoda Y.","Hirano T.","Taira K.","Wadhwa R.","Kaul S.C."],"citationCrossReferences":[{"database":"PubMed","id":"15109303"},{"database":"DOI","id":"10.1042/bj20040337"}],"title":"Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control.","publicationDate":"2004","journal":"Biochem. J.","firstPage":"605","lastPage":"610","volume":"380"},"referencePositions":["INTERACTION WITH CDKN2AIP"]},{"referenceNumber":69,"citation":{"id":"15186775","citationType":"journal article","authors":["An W.","Kim J.","Roeder R.G."],"citationCrossReferences":[{"database":"PubMed","id":"15186775"},{"database":"DOI","id":"10.1016/j.cell.2004.05.009"}],"title":"Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.","publicationDate":"2004","journal":"Cell","firstPage":"735","lastPage":"748","volume":"117"},"referencePositions":["INTERACTION WITH HRMT1L2; EP300 AND CARM1","FUNCTION"]},{"referenceNumber":70,"citation":{"id":"15136035","citationType":"journal article","authors":["Kojic S.","Medeot E.","Guccione E.","Krmac H.","Zara I.","Martinelli V.","Valle G.","Faulkner G."],"citationCrossReferences":[{"database":"PubMed","id":"15136035"},{"database":"DOI","id":"10.1016/j.jmb.2004.03.071"}],"title":"The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.","publicationDate":"2004","journal":"J. Mol. Biol.","firstPage":"313","lastPage":"325","volume":"339"},"referencePositions":["INTERACTION WITH ANKRD2"]},{"referenceNumber":71,"citation":{"id":"15053879","citationType":"journal article","authors":["Li H.-H.","Li A.G.","Sheppard H.M.","Liu X."],"citationCrossReferences":[{"database":"PubMed","id":"15053879"},{"database":"DOI","id":"10.1016/s1097-2765(04)00123-6"}],"title":"Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"867","lastPage":"878","volume":"13"},"referencePositions":["PHOSPHORYLATION AT THR-55","MUTAGENESIS OF THR-55","INTERACTION WITH TAF1"]},{"referenceNumber":72,"citation":{"id":"15053880","citationType":"journal article","authors":["Li M.","Brooks C.L.","Kon N.","Gu W."],"citationCrossReferences":[{"database":"PubMed","id":"15053880"},{"database":"DOI","id":"10.1016/s1097-2765(04)00157-1"}],"title":"A dynamic role of HAUSP in the p53-Mdm2 pathway.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"879","lastPage":"886","volume":"13"},"referencePositions":["DEUBIQUITINATION BY USP7"]},{"referenceNumber":73,"citation":{"id":"15340061","citationType":"journal article","authors":["Ghosh A.","Stewart D.","Matlashewski G."],"citationCrossReferences":[{"database":"PubMed","id":"15340061"},{"database":"DOI","id":"10.1128/mcb.24.18.7987-7997.2004"}],"title":"Regulation of human p53 activity and cell localization by alternative splicing.","publicationDate":"2004","journal":"Mol. Cell. Biol.","firstPage":"7987","lastPage":"7997","volume":"24"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 4)","FUNCTION","SUBCELLULAR LOCATION","UBIQUITINATION"]},{"referenceNumber":74,"citation":{"id":"15525938","citationType":"journal article","authors":["Chuikov S.","Kurash J.K.","Wilson J.R.","Xiao B.","Justin N.","Ivanov G.S.","McKinney K.","Tempst P.","Prives C.","Gamblin S.J.","Barlev N.A.","Reinberg D."],"citationCrossReferences":[{"database":"PubMed","id":"15525938"},{"database":"DOI","id":"10.1038/nature03117"}],"title":"Regulation of p53 activity through lysine methylation.","publicationDate":"2004","journal":"Nature","firstPage":"353","lastPage":"360","volume":"432"},"referencePositions":["METHYLATION AT LYS-372","MUTAGENESIS OF LYS-372"]},{"referenceNumber":75,"citation":{"id":"15448695","citationType":"journal article","authors":["Demonacos C.","Krstic-Demonacos M.","Smith L.","Xu D.","O'Connor D.P.","Jansson M.","La Thangue N.B."],"citationCrossReferences":[{"database":"PubMed","id":"15448695"},{"database":"DOI","id":"10.1038/ncb1170"}],"title":"A new effector pathway links ATM kinase with the DNA damage response.","publicationDate":"2004","journal":"Nat. Cell Biol.","firstPage":"968","lastPage":"976","volume":"6"},"referencePositions":["ACETYLATION AT LYS-382"]},{"referenceNumber":76,"citation":{"id":"14702041","citationType":"journal article","authors":["Katayama H.","Sasai K.","Kawai H.","Yuan Z.M.","Bondaruk J.","Suzuki F.","Fujii S.","Arlinghaus R.B.","Czerniak B.A.","Sen S."],"citationCrossReferences":[{"database":"PubMed","id":"14702041"},{"database":"DOI","id":"10.1038/ng1279"}],"title":"Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"55","lastPage":"62","volume":"36"},"referencePositions":["INTERACTION WITH AURKA","PHOSPHORYLATION AT SER-315"]},{"referenceNumber":77,"citation":{"id":"15687255","citationType":"journal article","authors":["Asher G.","Tsvetkov P.","Kahana C.","Shaul Y."],"citationCrossReferences":[{"database":"PubMed","id":"15687255"},{"database":"DOI","id":"10.1101/gad.319905"}],"title":"A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.","publicationDate":"2005","journal":"Genes Dev.","firstPage":"316","lastPage":"321","volume":"19"},"referencePositions":["INTERACTION WITH NQO1"]},{"referenceNumber":78,"citation":{"id":"16322561","citationType":"journal article","authors":["Hublitz P.","Kunowska N.","Mayer U.P.","Muller J.M.","Heyne K.","Yin N.","Fritzsche C.","Poli C.","Miguet L.","Schupp I.W.","van Grunsven L.A.","Potiers N.","van Dorsselaer A.","Metzger E.","Roemer K.","Schule R."],"citationCrossReferences":[{"database":"PubMed","id":"16322561"},{"database":"DOI","id":"10.1101/gad.351205"}],"title":"NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.","publicationDate":"2005","journal":"Genes Dev.","firstPage":"2912","lastPage":"2924","volume":"19"},"referencePositions":["INTERACTION WITH NOC2L"]},{"referenceNumber":79,"citation":{"id":"15701641","citationType":"journal article","authors":["Jalota-Badhwar A.","Singh K.","Pavithra L.","Kaul-Ghanekar R.","Jameel S.","Chattopadhyay S."],"citationCrossReferences":[{"database":"PubMed","id":"15701641"},{"database":"DOI","id":"10.1074/jbc.m413200200"}],"title":"Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"16019","lastPage":"16029","volume":"280"},"referencePositions":["RETRACTED PAPER"]},{"referenceNumber":80,"citation":{"id":"32144153","citationType":"journal article","authors":["Jalota A.","Singh K.","Pavithra L.","Kaul-Ghanekar R.","Jameel S.","Chattopadhyay S."],"citationCrossReferences":[{"database":"PubMed","id":"32144153"},{"database":"DOI","id":"10.1074/jbc.w120.012894"}],"publicationDate":"2020","journal":"J. Biol. Chem.","firstPage":"3390","lastPage":"3390","volume":"295"},"referencePositions":["RETRACTION NOTICE OF PUBMED:15701641"]},{"referenceNumber":81,"citation":{"id":"15855171","citationType":"journal article","authors":["Golubovskaya V.M.","Finch R.","Cance W.G."],"citationCrossReferences":[{"database":"PubMed","id":"15855171"},{"database":"DOI","id":"10.1074/jbc.m414172200"}],"title":"Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"25008","lastPage":"25021","volume":"280"},"referencePositions":["INTERACTION WITH PTK2/FAK1"]},{"referenceNumber":82,"citation":{"id":"16219768","citationType":"journal article","authors":["Chang N.-S.","Doherty J.","Ensign A.","Schultz L.","Hsu L.-J.","Hong Q."],"citationCrossReferences":[{"database":"PubMed","id":"16219768"},{"database":"DOI","id":"10.1074/jbc.m505590200"}],"title":"WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"43100","lastPage":"43108","volume":"280"},"referencePositions":["INTERACTION WITH WWOX","MUTAGENESIS OF SER-46"]},{"referenceNumber":83,"citation":{"id":"15866171","citationType":"journal article","authors":["Jones R.G.","Plas D.R.","Kubek S.","Buzzai M.","Mu J.","Xu Y.","Birnbaum M.J.","Thompson C.B."],"citationCrossReferences":[{"database":"PubMed","id":"15866171"},{"database":"DOI","id":"10.1016/j.molcel.2005.03.027"}],"title":"AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.","publicationDate":"2005","journal":"Mol. Cell","firstPage":"283","lastPage":"293","volume":"18"},"referencePositions":["PHOSPHORYLATION AT SER-15"]},{"referenceNumber":84,"citation":{"id":"17108107","citationType":"journal article","authors":["Zeng P.Y.","Berger S.L."],"citationCrossReferences":[{"database":"PubMed","id":"17108107"},{"database":"DOI","id":"10.1158/0008-5472.can-06-0999"}],"title":"LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.","publicationDate":"2006","journal":"Cancer Res.","firstPage":"10701","lastPage":"10708","volume":"66"},"referencePositions":["INTERACTION WITH STK11/LKB1","PHOSPHORYLATION AT SER-15 AND SER-392"]},{"referenceNumber":85,"citation":{"id":"16704422","citationType":"journal article","authors":["Blanco S.","Klimcakova L.","Vega F.M.","Lazo P.A."],"citationCrossReferences":[{"database":"PubMed","id":"16704422"},{"database":"DOI","id":"10.1111/j.1742-4658.2006.05256.x"}],"title":"The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines.","publicationDate":"2006","journal":"FEBS J.","firstPage":"2487","lastPage":"2504","volume":"273"},"referencePositions":["PHOSPHORYLATION AT THR-18"]},{"referenceNumber":86,"citation":{"id":"16376338","citationType":"journal article","authors":["Gu Y.-M.","Jin Y.-H.","Choi J.-K.","Baek K.-H.","Yeo C.-Y.","Lee K.-Y."],"citationCrossReferences":[{"database":"PubMed","id":"16376338"},{"database":"DOI","id":"10.1016/j.febslet.2005.12.024"}],"title":"Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.","publicationDate":"2006","journal":"FEBS Lett.","firstPage":"305","lastPage":"310","volume":"580"},"referencePositions":["INTERACTION WITH YWHAZ"]},{"referenceNumber":87,"citation":{"id":"16377624","citationType":"journal article","authors":["Yoshida K.","Liu H.","Miki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16377624"},{"database":"DOI","id":"10.1074/jbc.m512074200"}],"title":"Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"5734","lastPage":"5740","volume":"281"},"referencePositions":["PHOSPHORYLATION AT SER-46","INTERACTION WITH PRKCG"]},{"referenceNumber":88,"citation":{"id":"17189187","citationType":"journal article","authors":["Sykes S.M.","Mellert H.S.","Holbert M.A.","Li K.","Marmorstein R.","Lane W.S.","McMahon S.B."],"citationCrossReferences":[{"database":"PubMed","id":"17189187"},{"database":"DOI","id":"10.1016/j.molcel.2006.11.026"}],"title":"Acetylation of the p53 DNA-binding domain regulates apoptosis induction.","publicationDate":"2006","journal":"Mol. Cell","firstPage":"841","lastPage":"851","volume":"24"},"referencePositions":["FUNCTION","ACETYLATION AT LYS-120","VARIANTS ARG-120; GLU-120 AND MET-120","CHARACTERIZATION OF VARIANTS ARG-120; GLU-120 AND MET-120"]},{"referenceNumber":89,"citation":{"id":"17108971","citationType":"journal article","authors":["Huang J.","Perez-Burgos L.","Placek B.J.","Sengupta R.","Richter M.","Dorsey J.A.","Kubicek S.","Opravil S.","Jenuwein T.","Berger S.L."],"citationCrossReferences":[{"database":"PubMed","id":"17108971"},{"database":"DOI","id":"10.1038/nature05287"}],"title":"Repression of p53 activity by Smyd2-mediated methylation.","publicationDate":"2006","journal":"Nature","firstPage":"629","lastPage":"632","volume":"444"},"referencePositions":["METHYLATION AT LYS-370","MUTAGENESIS OF LYS-370"]},{"referenceNumber":90,"citation":{"id":"16845383","citationType":"journal article","authors":["Tang J.","Qu L.K.","Zhang J.","Wang W.","Michaelson J.S.","Degenhardt Y.Y.","El-Deiry W.S.","Yang X."],"citationCrossReferences":[{"database":"PubMed","id":"16845383"},{"database":"DOI","id":"10.1038/ncb1442"}],"title":"Critical role for Daxx in regulating Mdm2.","publicationDate":"2006","journal":"Nat. Cell Biol.","firstPage":"855","lastPage":"862","volume":"8"},"referencePositions":["INTERACTION WITH DAXX"]},{"referenceNumber":91,"citation":{"id":"16415881","citationType":"journal article","authors":["Couture J.-F.","Collazo E.","Hauk G.","Trievel R.C."],"citationCrossReferences":[{"database":"PubMed","id":"16415881"},{"database":"DOI","id":"10.1038/nsmb1045"}],"title":"Structural basis for the methylation site specificity of SET7/9.","publicationDate":"2006","journal":"Nat. Struct. Mol. Biol.","firstPage":"140","lastPage":"146","volume":"13"},"referencePositions":["MOTIF","METHYLATION AT LYS-372"]},{"referenceNumber":92,"citation":{"id":"17145718","citationType":"journal article","authors":["Budhram-Mahadeo V.S.","Bowen S.","Lee S.","Perez-Sanchez C.","Ensor E.","Morris P.J.","Latchman D.S."],"citationCrossReferences":[{"database":"PubMed","id":"17145718"},{"database":"DOI","id":"10.1093/nar/gkl878"}],"title":"Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.","publicationDate":"2006","journal":"Nucleic Acids Res.","firstPage":"6640","lastPage":"6652","volume":"34"},"referencePositions":["INTERACTION WITH POU4F2"]},{"referenceNumber":93,"citation":{"id":"17254968","citationType":"journal article","authors":["Sun P.","Yoshizuka N.","New L.","Moser B.A.","Li Y.","Liao R.","Xie C.","Chen J.","Deng Q.","Yamout M.","Dong M.Q.","Frangou C.G.","Yates J.R. III","Wright P.E.","Han J."],"citationCrossReferences":[{"database":"PubMed","id":"17254968"},{"database":"DOI","id":"10.1016/j.cell.2006.11.050"}],"title":"PRAK is essential for ras-induced senescence and tumor suppression.","publicationDate":"2007","journal":"Cell","firstPage":"295","lastPage":"308","volume":"128"},"referencePositions":["PHOSPHORYLATION AT SER-37","MUTAGENESIS OF SER-37"]},{"referenceNumber":94,"citation":{"id":"17719541","citationType":"journal article","authors":["Das S.","Raj L.","Zhao B.","Kimura Y.","Bernstein A.","Aaronson S.A.","Lee S.W."],"citationCrossReferences":[{"database":"PubMed","id":"17719541"},{"database":"DOI","id":"10.1016/j.cell.2007.06.013"}],"title":"Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.","publicationDate":"2007","journal":"Cell","firstPage":"624","lastPage":"637","volume":"130"},"referencePositions":["INTERACTION WITH ZNF385A","CHARACTERIZATION OF VARIANTS ALA-143; HIS-175 AND PRO-175"]},{"referenceNumber":95,"citation":{"id":"17170702","citationType":"journal article","authors":["Yamasaki S.","Yagishita N.","Sasaki T.","Nakazawa M.","Kato Y.","Yamadera T.","Bae E.","Toriyama S.","Ikeda R.","Zhang L.","Fujitani K.","Yoo E.","Tsuchimochi K.","Ohta T.","Araya N.","Fujita H.","Aratani S.","Eguchi K.","Komiya S.","Maruyama I.","Higashi N.","Sato M.","Senoo H.","Ochi T.","Yokoyama S.","Amano T.","Kim J.","Gay S.","Fukamizu A.","Nishioka K.","Tanaka K.","Nakajima T."],"citationCrossReferences":[{"database":"PubMed","id":"17170702"},{"database":"DOI","id":"10.1038/sj.emboj.7601490"}],"title":"Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.","publicationDate":"2007","journal":"EMBO J.","firstPage":"113","lastPage":"122","volume":"26"},"referencePositions":["UBIQUITINATION","INTERACTION WITH SYVN1","SUBCELLULAR LOCATION"]},{"referenceNumber":96,"citation":{"id":"17245430","citationType":"journal article","authors":["Li H.H.","Cai X.","Shouse G.P.","Piluso L.G.","Liu X."],"citationCrossReferences":[{"database":"PubMed","id":"17245430"},{"database":"DOI","id":"10.1038/sj.emboj.7601519"}],"title":"A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.","publicationDate":"2007","journal":"EMBO J.","firstPage":"402","lastPage":"411","volume":"26"},"referencePositions":["INTERACTION WITH PPP2CA; PPP2R1A; PPP2R2A AND PPP2R5C"]},{"referenceNumber":97,"citation":{"id":"17904127","citationType":"journal article","authors":["Zhou X.","Yang G.","Huang R.","Chen X.","Hu G."],"citationCrossReferences":[{"database":"PubMed","id":"17904127"},{"database":"DOI","id":"10.1016/j.febslet.2007.09.025"}],"title":"SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.","publicationDate":"2007","journal":"FEBS Lett.","firstPage":"4943","lastPage":"4948","volume":"581"},"referencePositions":["INTERACTION WITH ARMC10"]},{"referenceNumber":98,"citation":{"id":"18022393","citationType":"journal article","authors":["Arai S.","Matsushita A.","Du K.","Yagi K.","Okazaki Y.","Kurokawa R."],"citationCrossReferences":[{"database":"PubMed","id":"18022393"},{"database":"DOI","id":"10.1016/j.febslet.2007.11.022"}],"title":"Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9.","publicationDate":"2007","journal":"FEBS Lett.","firstPage":"5649","lastPage":"5657","volume":"581"},"referencePositions":["PHOSPHORYLATION AT SER-9"]},{"referenceNumber":99,"citation":{"id":"17467953","citationType":"journal article","authors":["Piskacek S.","Gregor M.","Nemethova M.","Grabner M.","Kovarik P.","Piskacek M."],"citationCrossReferences":[{"database":"PubMed","id":"17467953"},{"database":"DOI","id":"10.1016/j.ygeno.2007.02.003"}],"title":"Nine-amino-acid transactivation domain: establishment and prediction utilities.","publicationDate":"2007","journal":"Genomics","firstPage":"756","lastPage":"768","volume":"89"},"referencePositions":["DOMAIN"]},{"referenceNumber":100,"citation":{"id":"17121812","citationType":"journal article","authors":["Yang W.","Rozan L.M.","McDonald E.R. III","Navaraj A.","Liu J.J.","Matthew E.M.","Wang W.","Dicker D.T.","El-Deiry W.S."],"citationCrossReferences":[{"database":"PubMed","id":"17121812"},{"database":"DOI","id":"10.1074/jbc.m610793200"}],"title":"CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"3273","lastPage":"3281","volume":"282"},"referencePositions":["INTERACTION WITH RFFL AND RNF34"]},{"referenceNumber":101,"citation":{"id":"17317671","citationType":"journal article","authors":["Zhao Y.","Katzman R.B.","Delmolino L.M.","Bhat I.","Zhang Y.","Gurumurthy C.B.","Germaniuk-Kurowska A.","Reddi H.V.","Solomon A.","Zeng M.S.","Kung A.","Ma H.","Gao Q.","Dimri G.","Stanculescu A.","Miele L.","Wu L.","Griffin J.D.","Wazer D.E.","Band H.","Band V."],"citationCrossReferences":[{"database":"PubMed","id":"17317671"},{"database":"DOI","id":"10.1074/jbc.m608974200"}],"title":"The notch regulator MAML1 interacts with p53 and functions as a coactivator.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"11969","lastPage":"11981","volume":"282"},"referencePositions":["FUNCTION","INTERACTION WITH MAML1"]},{"referenceNumber":102,"citation":{"id":"17591690","citationType":"journal article","authors":["Lee J.-H.","Kim H.-S.","Lee S.-J.","Kim K.-T."],"citationCrossReferences":[{"database":"PubMed","id":"17591690"},{"database":"DOI","id":"10.1242/jcs.03468"}],"title":"Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.","publicationDate":"2007","journal":"J. Cell Sci.","firstPage":"2259","lastPage":"2271","volume":"120"},"referencePositions":["PHOSPHORYLATION AT SER-15; SER-33 AND SER-46","INTERACTION WITH CDK5","SUBCELLULAR LOCATION"]},{"referenceNumber":103,"citation":{"id":"17332504","citationType":"journal article","authors":["Takahashi K.","Yoshida N.","Murakami N.","Kawata K.","Ishizaki H.","Tanaka-Okamoto M.","Miyoshi J.","Zinn A.R.","Shime H.","Inoue N."],"citationCrossReferences":[{"database":"PubMed","id":"17332504"},{"database":"DOI","id":"10.1091/mbc.e06-08-0747"}],"title":"Dynamic regulation of p53 subnuclear localization and senescence by MORC3.","publicationDate":"2007","journal":"Mol. Biol. Cell","firstPage":"1701","lastPage":"1709","volume":"18"},"referencePositions":["INTERACTION WITH MORC3"]},{"referenceNumber":104,"citation":{"id":"17349958","citationType":"journal article","authors":["Taira N.","Nihira K.","Yamaguchi T.","Miki Y.","Yoshida K."],"citationCrossReferences":[{"database":"PubMed","id":"17349958"},{"database":"DOI","id":"10.1016/j.molcel.2007.02.007"}],"title":"DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.","publicationDate":"2007","journal":"Mol. Cell","firstPage":"725","lastPage":"738","volume":"25"},"referencePositions":["FUNCTION","PHOSPHORYLATION AT SER-46","MUTAGENESIS OF SER-46"]},{"referenceNumber":105,"citation":{"id":"17805299","citationType":"journal article","authors":["Huang J.","Sengupta R.","Espejo A.B.","Lee M.G.","Dorsey J.A.","Richter M.","Opravil S.","Shiekhattar R.","Bedford M.T.","Jenuwein T.","Berger S.L."],"citationCrossReferences":[{"database":"PubMed","id":"17805299"},{"database":"DOI","id":"10.1038/nature06092"}],"title":"p53 is regulated by the lysine demethylase LSD1.","publicationDate":"2007","journal":"Nature","firstPage":"105","lastPage":"108","volume":"449"},"referencePositions":["DEMETHYLATION BY KDM1A"]},{"referenceNumber":106,"citation":{"id":"17707234","citationType":"journal article","authors":["Shi X.","Kachirskaia I.","Yamaguchi H.","West L.E.","Wen H.","Wang E.W.","Dutta S.","Appella E.","Gozani O."],"citationCrossReferences":[{"database":"PubMed","id":"17707234"},{"database":"DOI","id":"10.1016/j.molcel.2007.07.012"}],"title":"Modulation of p53 function by SET8-mediated methylation at lysine 382.","publicationDate":"2007","journal":"Mol. Cell","firstPage":"636","lastPage":"646","volume":"27"},"referencePositions":["METHYLATION AT LYS-382","MUTAGENESIS OF LYS-382"]},{"referenceNumber":107,"citation":{"id":"17525332","citationType":"journal article","authors":["Matsuoka S.","Ballif B.A.","Smogorzewska A.","McDonald E.R. III","Hurov K.E.","Luo J.","Bakalarski C.E.","Zhao Z.","Solimini N.","Lerenthal Y.","Shiloh Y.","Gygi S.P.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17525332"},{"database":"DOI","id":"10.1126/science.1140321"}],"title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.","publicationDate":"2007","journal":"Science","firstPage":"1160","lastPage":"1166","volume":"316"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic kidney","type":"TISSUE"}]},{"referenceNumber":108,"citation":{"id":"18249187","citationType":"journal article","authors":["Jin Y.H.","Kim Y.J.","Kim D.W.","Baek K.H.","Kang B.Y.","Yeo C.Y.","Lee K.Y."],"citationCrossReferences":[{"database":"PubMed","id":"18249187"},{"database":"DOI","id":"10.1016/j.bbrc.2008.01.114"}],"title":"Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53.","publicationDate":"2008","journal":"Biochem. Biophys. Res. Commun.","firstPage":"690","lastPage":"695","volume":"368"},"referencePositions":["ACETYLATION","DEACETYLATION BY SIRT2"]},{"referenceNumber":109,"citation":{"id":"18585004","citationType":"journal article","authors":["Xie P.","Tian C.","An L.","Nie J.","Lu K.","Xing G.","Zhang L.","He F."],"citationCrossReferences":[{"database":"PubMed","id":"18585004"},{"database":"DOI","id":"10.1016/j.cellsig.2008.05.012"}],"title":"Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes.","publicationDate":"2008","journal":"Cell. Signal.","firstPage":"1671","lastPage":"1678","volume":"20"},"referencePositions":["INTERACTION WITH SETD2"]},{"referenceNumber":110,"citation":{"id":"18690848","citationType":"journal article","authors":["Clark D.W.","Mitra A.","Fillmore R.A.","Jiang W.G.","Samant R.S.","Fodstad O.","Shevde L.A."],"citationCrossReferences":[{"database":"PubMed","id":"18690848"},{"database":"DOI","id":"10.2174/156800908785133196"}],"title":"NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.","publicationDate":"2008","journal":"Curr. Cancer Drug Targets","firstPage":"421","lastPage":"430","volume":"8"},"referencePositions":["INTERACTION WITH NUPR1"]},{"referenceNumber":111,"citation":{"id":"18206965","citationType":"journal article","authors":["Lim S.T.","Chen X.L.","Lim Y.","Hanson D.A.","Vo T.T.","Howerton K.","Larocque N.","Fisher S.J.","Schlaepfer D.D.","Ilic D."],"citationCrossReferences":[{"database":"PubMed","id":"18206965"},{"database":"DOI","id":"10.1016/j.molcel.2007.11.031"}],"title":"Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"9","lastPage":"22","volume":"29"},"referencePositions":["UBIQUITINATION","SUBCELLULAR LOCATION"]},{"referenceNumber":112,"citation":{"id":"17954561","citationType":"journal article","authors":["Iizuka M.","Sarmento O.F.","Sekiya T.","Scrable H.","Allis C.D.","Smith M.M."],"citationCrossReferences":[{"database":"PubMed","id":"17954561"},{"database":"DOI","id":"10.1128/mcb.00662-07"}],"title":"Hbo1 Links p53-dependent stress signaling to DNA replication licensing.","publicationDate":"2008","journal":"Mol. Cell. Biol.","firstPage":"140","lastPage":"153","volume":"28"},"referencePositions":["INTERACTION WITH KAT7"]},{"referenceNumber":113,"citation":{"id":"17967874","citationType":"journal article","authors":["Shouse G.P.","Cai X.","Liu X."],"citationCrossReferences":[{"database":"PubMed","id":"17967874"},{"database":"DOI","id":"10.1128/mcb.00983-07"}],"title":"Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.","publicationDate":"2008","journal":"Mol. Cell. Biol.","firstPage":"448","lastPage":"456","volume":"28"},"referencePositions":["INTERACTION WITH PPP2CA; PPP2R1A AND PPP2R5C","PHOSPHORYLATION AT SER-15 BY ATM","MUTAGENESIS OF SER-15"]},{"referenceNumber":114,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":115,"citation":{"id":"19536131","citationType":"journal article","authors":["Lee E.-W.","Lee M.-S.","Camus S.","Ghim J.","Yang M.-R.","Oh W.","Ha N.-C.","Lane D.P.","Song J."],"citationCrossReferences":[{"database":"PubMed","id":"19536131"},{"database":"DOI","id":"10.1038/emboj.2009.164"}],"title":"Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.","publicationDate":"2009","journal":"EMBO J.","firstPage":"2100","lastPage":"2113","volume":"28"},"referencePositions":["INTERACTION WITH MKRN1","MUTAGENESIS OF 291-LYS-LYS-292","UBIQUITINATION AT LYS-291 AND LYS-292 BY MKRN1"]},{"referenceNumber":116,"citation":{"id":"19473992","citationType":"journal article","authors":["Yang X.","Li H.","Zhou Z.","Wang W.H.","Deng A.","Andrisani O.","Liu X."],"citationCrossReferences":[{"database":"PubMed","id":"19473992"},{"database":"DOI","id":"10.1074/jbc.c109.001560"}],"title":"Plk1-mediated phosphorylation of Topors regulates p53 stability.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"18588","lastPage":"18592","volume":"284"},"referencePositions":["UBIQUITINATION BY TOPORS"]},{"referenceNumber":117,"citation":{"id":"19033443","citationType":"journal article","authors":["Kruse J.P.","Gu W."],"citationCrossReferences":[{"database":"PubMed","id":"19033443"},{"database":"DOI","id":"10.1074/jbc.m805658200"}],"title":"MSL2 promotes Mdm2-independent cytoplasmic localization of p53.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"3250","lastPage":"3263","volume":"284"},"referencePositions":["UBIQUITINATION AT LYS-351 AND LYS-357","SUBCELLULAR LOCATION"]},{"referenceNumber":118,"citation":{"id":"19837670","citationType":"journal article","authors":["Li D.Q.","Divijendra Natha Reddy S.","Pakala S.B.","Wu X.","Zhang Y.","Rayala S.K.","Kumar R."],"citationCrossReferences":[{"database":"PubMed","id":"19837670"},{"database":"DOI","id":"10.1074/jbc.m109.056499"}],"title":"MTA1 coregulator regulates p53 stability and function.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"34545","lastPage":"34552","volume":"284"},"referencePositions":["INTERACTION WITH MTA1 AND COP1","UBIQUITINATION"]},{"referenceNumber":119,"citation":{"id":"19776115","citationType":"journal article","authors":["Hwang E.S.","Zhang Z.","Cai H.","Huang D.Y.","Huong S.M.","Cha C.Y.","Huang E.S."],"citationCrossReferences":[{"database":"PubMed","id":"19776115"},{"database":"DOI","id":"10.1128/jvi.00304-09"}],"title":"Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein.","publicationDate":"2009","journal":"J. Virol.","firstPage":"12388","lastPage":"12398","volume":"83"},"referencePositions":["INTERACTION WITH HHV-5 PROTEIN UL123 (MICROBIAL INFECTION)"]},{"referenceNumber":120,"citation":{"id":"19854137","citationType":"journal article","authors":["Li X.","Wu L.","Corsa C.A.","Kunkel S.","Dou Y."],"citationCrossReferences":[{"database":"PubMed","id":"19854137"},{"database":"DOI","id":"10.1016/j.molcel.2009.07.031"}],"title":"Two mammalian MOF complexes regulate transcription activation by distinct mechanisms.","publicationDate":"2009","journal":"Mol. Cell","firstPage":"290","lastPage":"301","volume":"36"},"referencePositions":["ACETYLATION AT LYS-120"]},{"referenceNumber":121,"citation":{"id":"19509332","citationType":"journal article","authors":["Sun L.","Shi L.","Li W.","Yu W.","Liang J.","Zhang H.","Yang X.","Wang Y.","Li R.","Yao X.","Yi X.","Shang Y."],"citationCrossReferences":[{"database":"PubMed","id":"19509332"},{"database":"DOI","id":"10.1073/pnas.0901864106"}],"title":"JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10195","lastPage":"10200","volume":"106"},"referencePositions":["INTERACTION WITH FBXO42"]},{"referenceNumber":122,"citation":{"id":"19556538","citationType":"journal article","authors":["Allton K.","Jain A.K.","Herz H.M.","Tsai W.W.","Jung S.Y.","Qin J.","Bergmann A.","Johnson R.L.","Barton M.C."],"citationCrossReferences":[{"database":"PubMed","id":"19556538"},{"database":"DOI","id":"10.1073/pnas.0813177106"}],"title":"Trim24 targets endogenous p53 for degradation.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11612","lastPage":"11616","volume":"106"},"referencePositions":["FUNCTION","UBIQUITINATION","INTERACTION WITH TRIM24"]},{"referenceNumber":123,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-381 AND LYS-382","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":124,"citation":{"id":"20096117","citationType":"journal article","authors":["Wilhelm E.","Kornete M.","Targat B.","Vigneault-Edwards J.","Frontini M.","Tora L.","Benecke A.","Bell B."],"citationCrossReferences":[{"database":"PubMed","id":"20096117"},{"database":"DOI","id":"10.1186/1471-2199-11-10"}],"title":"TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53.","publicationDate":"2010","journal":"BMC Mol. Biol.","firstPage":"10","lastPage":"10","volume":"11"},"referencePositions":["INTERACTION WITH TAF6 ISOFORMS 1 AND 4"]},{"referenceNumber":125,"citation":{"id":"20096447","citationType":"journal article","authors":["Yuan J.","Luo K.","Zhang L.","Cheville J.C.","Lou Z."],"citationCrossReferences":[{"database":"PubMed","id":"20096447"},{"database":"DOI","id":"10.1016/j.cell.2009.12.032"}],"title":"USP10 regulates p53 localization and stability by deubiquitinating p53.","publicationDate":"2010","journal":"Cell","firstPage":"384","lastPage":"396","volume":"140"},"referencePositions":["UBIQUITINATION","DEUBIQUITINATION BY USP10"]},{"referenceNumber":126,"citation":{"id":"20673990","citationType":"journal article","authors":["Huarte M.","Guttman M.","Feldser D.","Garber M.","Koziol M.J.","Kenzelmann-Broz D.","Khalil A.M.","Zuk O.","Amit I.","Rabani M.","Attardi L.D.","Regev A.","Lander E.S.","Jacks T.","Rinn J.L."],"citationCrossReferences":[{"database":"PubMed","id":"20673990"},{"database":"DOI","id":"10.1016/j.cell.2010.06.040"}],"title":"A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.","publicationDate":"2010","journal":"Cell","firstPage":"409","lastPage":"419","volume":"142"},"referencePositions":["FUNCTION"]},{"referenceNumber":127,"citation":{"id":"20041275","citationType":"journal article","authors":["Venerando A.","Marin O.","Cozza G.","Bustos V.H.","Sarno S.","Pinna L.A."],"citationCrossReferences":[{"database":"PubMed","id":"20041275"},{"database":"DOI","id":"10.1007/s00018-009-0236-7"}],"title":"Isoform specific phosphorylation of p53 by protein kinase CK1.","publicationDate":"2010","journal":"Cell. Mol. Life Sci.","firstPage":"1105","lastPage":"1118","volume":"67"},"referencePositions":["PHOSPHORYLATION AT SER-20 BY CSNK1D/CK1"]},{"referenceNumber":128,"citation":{"id":"20385133","citationType":"journal article","authors":["Lim S.O.","Kim H.","Jung G."],"citationCrossReferences":[{"database":"PubMed","id":"20385133"},{"database":"DOI","id":"10.1016/j.febslet.2010.04.006"}],"title":"p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.","publicationDate":"2010","journal":"FEBS Lett.","firstPage":"2231","lastPage":"2236","volume":"584"},"referencePositions":["INTERACTION WITH SNAI1","CHARACTERIZATION OF VARIANTS LEU-110; PRO-155; HIS-175; SER-232; SER-249; HIS-273 AND TRP-282","MUTAGENESIS OF ARG-248"]},{"referenceNumber":129,"citation":{"id":"19880522","citationType":"journal article","authors":["Lim S.T.","Miller N.L.","Nam J.O.","Chen X.L.","Lim Y.","Schlaepfer D.D."],"citationCrossReferences":[{"database":"PubMed","id":"19880522"},{"database":"DOI","id":"10.1074/jbc.m109.064212"}],"title":"Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"1743","lastPage":"1753","volume":"285"},"referencePositions":["INTERACTION WITH PTK2B/PYK2 AND MDM2","UBIQUITINATION","SUBCELLULAR LOCATION"]},{"referenceNumber":130,"citation":{"id":"20118233","citationType":"journal article","authors":["Huang J.","Dorsey J.","Chuikov S.","Perez-Burgos L.","Zhang X.","Jenuwein T.","Reinberg D.","Berger S.L."],"citationCrossReferences":[{"database":"PubMed","id":"20118233"},{"database":"DOI","id":"10.1074/jbc.m109.062588"}],"title":"G9a and Glp methylate lysine 373 in the tumor suppressor p53.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"9636","lastPage":"9641","volume":"285"},"referencePositions":["METHYLATION AT LYS-373","MUTAGENESIS OF LYS-373"]},{"referenceNumber":131,"citation":{"id":"CI-FP6KI8V4R50TD","citationType":"journal article","authors":["Huang J.","Dorsey J.","Chuikov S.","Perez-Burgos L.","Zhang X.","Jenuwein T.","Reinberg D.","Berger S.L."],"publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"18122","lastPage":"18122","volume":"285"},"referencePositions":["ERRATUM OF PUBMED:20118233"]},{"referenceNumber":132,"citation":{"id":"20124405","citationType":"journal article","authors":["Chen X.","Zhu H.","Yuan M.","Fu J.","Zhou Y.","Ma L."],"citationCrossReferences":[{"database":"PubMed","id":"20124405"},{"database":"DOI","id":"10.1074/jbc.m109.094243"}],"title":"G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"12823","lastPage":"12830","volume":"285"},"referencePositions":["PHOSPHORYLATION AT THR-55","INTERACTION WITH GRK5"]},{"referenceNumber":133,"citation":{"id":"20228809","citationType":"journal article","authors":["Drost J.","Mantovani F.","Tocco F.","Elkon R.","Comel A.","Holstege H.","Kerkhoven R.","Jonkers J.","Voorhoeve P.M.","Agami R.","Del Sal G."],"citationCrossReferences":[{"database":"PubMed","id":"20228809"},{"database":"DOI","id":"10.1038/ncb2038"}],"title":"BRD7 is a candidate tumour suppressor gene required for p53 function.","publicationDate":"2010","journal":"Nat. Cell Biol.","firstPage":"380","lastPage":"389","volume":"12"},"referencePositions":["INTERACTION WITH BRD7","ACETYLATION AT LYS-382"]},{"referenceNumber":134,"citation":{"id":"20173098","citationType":"journal article","authors":["Fu X.","Yucer N.","Liu S.","Li M.","Yi P.","Mu J.J.","Yang T.","Chu J.","Jung S.Y.","O'Malley B.W.","Gu W.","Qin J.","Wang Y."],"citationCrossReferences":[{"database":"PubMed","id":"20173098"},{"database":"DOI","id":"10.1073/pnas.0912094107"}],"title":"RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4579","lastPage":"4584","volume":"107"},"referencePositions":["UBIQUITINATION BY RFWD3"]},{"referenceNumber":135,"citation":{"id":"20660729","citationType":"journal article","authors":["Burrows A.E.","Smogorzewska A.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"20660729"},{"database":"DOI","id":"10.1073/pnas.1009559107"}],"title":"Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"14280","lastPage":"14285","volume":"107"},"referencePositions":["INTERACTION WITH BRD7"]},{"referenceNumber":136,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":137,"citation":{"id":"21952639","citationType":"journal article","authors":["Mori T.","Ikeda D.D.","Fukushima T.","Takenoshita S.","Kochi H."],"citationCrossReferences":[{"database":"PubMed","id":"21952639"},{"database":"DOI","id":"10.4161/cc.10.19.17176"}],"title":"NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.","publicationDate":"2011","journal":"Cell Cycle","firstPage":"3284","lastPage":"3299","volume":"10"},"referencePositions":["INTERACTION WITH UHRF2"]},{"referenceNumber":138,"citation":{"id":"21597459","citationType":"journal article","authors":["Jung J.H.","Bae S.","Lee J.Y.","Woo S.R.","Cha H.J.","Yoon Y.","Suh K.S.","Lee S.J.","Park I.C.","Jin Y.W.","Lee K.H.","An S.","Lee J.H."],"citationCrossReferences":[{"database":"PubMed","id":"21597459"},{"database":"DOI","id":"10.1038/cdd.2011.57"}],"title":"E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.","publicationDate":"2011","journal":"Cell Death Differ.","firstPage":"1865","lastPage":"1875","volume":"18"},"referencePositions":["INTERACTION WITH MUL1","SUBCELLULAR LOCATION","UBIQUITINATION AT LYS-24 BY MUL1","MUTAGENESIS OF LYS-24"]},{"referenceNumber":139,"citation":{"id":"20959462","citationType":"journal article","authors":["Wu L.","Ma C.A.","Zhao Y.","Jain A."],"citationCrossReferences":[{"database":"PubMed","id":"20959462"},{"database":"DOI","id":"10.1074/jbc.m110.174755"}],"title":"Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"2236","lastPage":"2244","volume":"286"},"referencePositions":["FUNCTION","INTERACTION WITH AURKB AND NOC2L","PHOSPHORYLATION AT SER-183; SER-269 AND THR-284","CHARACTERIZATION OF VARIANT ALA-284","MUTAGENESIS OF SER-183; SER-269 AND THR-284","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":140,"citation":{"id":"22914926","citationType":"journal article","authors":["Xu L.","Hu J.","Zhao Y.","Hu J.","Xiao J.","Wang Y.","Ma D.","Chen Y."],"citationCrossReferences":[{"database":"PubMed","id":"22914926"},{"database":"DOI","id":"10.1007/s10495-012-0754-x"}],"title":"PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway.","publicationDate":"2012","journal":"Apoptosis","firstPage":"1235","lastPage":"1245","volume":"17"},"referencePositions":["INTERACTION WITH MDM2 AND PDCD5","SUBCELLULAR LOCATION"]},{"referenceNumber":141,"citation":{"id":"35122041","citationType":"journal article","authors":["Li M.","He X.","Guo W.","Yu H.","Zhang S.","Wang N.","Liu G.","Sa R.","Shen X.","Jiang Y.","Tang Y.","Zhuo Y.","Yin C.","Tu Q.","Li N.","Nie X.","Li Y.","Hu Z.","Zhu H.","Ding J.","Li Z.","Liu T.","Zhang F.","Zhou H.","Li S.","Yue J.","Yan Z.","Cheng S.","Tao Y.","Yin H."],"citationCrossReferences":[{"database":"PubMed","id":"35122041"},{"database":"DOI","id":"10.1038/s43018-020-0086-7"}],"title":"Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways.","publicationDate":"2020","journal":"Nat. Cancer","firstPage":"735","lastPage":"747","volume":"1"},"referencePositions":["INTERACTION WITH ALDOB AND G6PD"]},{"referenceNumber":142,"citation":{"id":"21946351","citationType":"journal article","authors":["Stacey S.N.","Sulem P.","Jonasdottir A.","Masson G.","Gudmundsson J.","Gudbjartsson D.F.","Magnusson O.T.","Gudjonsson S.A.","Sigurgeirsson B.","Thorisdottir K.","Ragnarsson R.","Benediktsdottir K.R.","Nexo B.A.","Tjonneland A.","Overvad K.","Rudnai P.","Gurzau E.","Koppova K.","Hemminki K.","Corredera C.","Fuentelsaz V.","Grasa P.","Navarrete S.","Fuertes F.","Garcia-Prats M.D.","Sanambrosio E.","Panadero A.","De Juan A.","Garcia A.","Rivera F.","Planelles D.","Soriano V.","Requena C.","Aben K.K.","van Rossum M.M.","Cremers R.G.","van Oort I.M.","van Spronsen D.J.","Schalken J.A.","Peters W.H.","Helfand B.T.","Donovan J.L.","Hamdy F.C.","Badescu D.","Codreanu O.","Jinga M.","Csiki I.E.","Constantinescu V.","Badea P.","Mates I.N.","Dinu D.E.","Constantin A.","Mates D.","Kristjansdottir S.","Agnarsson B.A.","Jonsson E.","Barkardottir R.B.","Einarsson G.V.","Sigurdsson F.","Moller P.H.","Stefansson T.","Valdimarsson T.","Johannsson O.T.","Sigurdsson H.","Jonsson T.","Jonasson J.G.","Tryggvadottir L.","Rice T.","Hansen H.M.","Xiao Y.","Lachance D.H.","O'Neill B.P.","Kosel M.L.","Decker P.A.","Thorleifsson G.","Johannsdottir H.","Helgadottir H.T.","Sigurdsson A.","Steinthorsdottir V.","Lindblom A.","Sandler R.S.","Keku T.O.","Banasik K.","Jorgensen T.","Witte D.R.","Hansen T.","Pedersen O.","Jinga V.","Neal D.E.","Catalona W.J.","Wrensch M.","Wiencke J.","Jenkins R.B.","Nagore E.","Vogel U.","Kiemeney L.A.","Kumar R.","Mayordomo J.I.","Olafsson J.H.","Kong A.","Thorsteinsdottir U.","Rafnar T.","Stefansson K."],"citationCrossReferences":[{"database":"PubMed","id":"21946351"},{"database":"DOI","id":"10.1038/ng.926"}],"title":"A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.","publicationDate":"2011","journal":"Nat. Genet.","firstPage":"1098","lastPage":"1103","volume":"43"},"referencePositions":["INVOLVEMENT IN BCC7"]},{"referenceNumber":143,"citation":{"id":"21317932","citationType":"journal article","authors":["Hou X.","Liu J.E.","Liu W.","Liu C.Y.","Liu Z.Y.","Sun Z.Y."],"citationCrossReferences":[{"database":"PubMed","id":"21317932"},{"database":"DOI","id":"10.1038/onc.2011.19"}],"title":"A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.","publicationDate":"2011","journal":"Oncogene","firstPage":"2933","lastPage":"2942","volume":"30"},"referencePositions":["INTERACTION WITH NUAK1","PHOSPHORYLATION AT SER-15 AND SER-392"]},{"referenceNumber":144,"citation":{"id":"22726440","citationType":"journal article","authors":["Vaseva A.V.","Marchenko N.D.","Ji K.","Tsirka S.E.","Holzmann S.","Moll U.M."],"citationCrossReferences":[{"database":"PubMed","id":"22726440"},{"database":"DOI","id":"10.1016/j.cell.2012.05.014"}],"title":"p53 opens the mitochondrial permeability transition pore to trigger necrosis.","publicationDate":"2012","journal":"Cell","firstPage":"1536","lastPage":"1548","volume":"149"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH PPIF"]},{"referenceNumber":145,"citation":{"id":"22214662","citationType":"journal article","authors":["Bennett R.L.","Pan Y.","Christian J.","Hui T.","May W.S. Jr."],"citationCrossReferences":[{"database":"PubMed","id":"22214662"},{"database":"DOI","id":"10.4161/cc.11.2.18999"}],"title":"The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest.","publicationDate":"2012","journal":"Cell Cycle","firstPage":"407","lastPage":"417","volume":"11"},"referencePositions":["INTERACTION WITH UBC9","PHOSPHORYLATION AT SER-392","SUMOYLATION AT LYS-386"]},{"referenceNumber":146,"citation":{"id":"22522597","citationType":"journal article","authors":["Lee S.","Kim J.Y.","Kim Y.J.","Seok K.O.","Kim J.H.","Chang Y.J.","Kang H.Y.","Park J.H."],"citationCrossReferences":[{"database":"PubMed","id":"22522597"},{"database":"DOI","id":"10.1038/cdd.2012.40"}],"title":"Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses.","publicationDate":"2012","journal":"Cell Death Differ.","firstPage":"1613","lastPage":"1622","volume":"19"},"referencePositions":["INTERACTION WITH NOP53"]},{"referenceNumber":147,"citation":{"id":"22945289","citationType":"journal article","authors":["Iijima K.","Yamada H.","Miharu M.","Imadome K.","Miyagawa Y.","Akimoto S.","Kobayashi K.","Okita H.","Nakazawa A.","Fujiwara S.","Fujimoto J.","Kiyokawa N."],"citationCrossReferences":[{"database":"PubMed","id":"22945289"},{"database":"DOI","id":"10.1002/eji.201242530"}],"title":"ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis.","publicationDate":"2012","journal":"Eur. J. Immunol.","firstPage":"3405","lastPage":"3415","volume":"42"},"referencePositions":["INTERACTION WITH ZNF385B"]},{"referenceNumber":148,"citation":{"id":"22864287","citationType":"journal article","authors":["Cui G.","Park S.","Badeaux A.I.","Kim D.","Lee J.","Thompson J.R.","Yan F.","Kaneko S.","Yuan Z.","Botuyan M.V.","Bedford M.T.","Cheng J.Q.","Mer G."],"citationCrossReferences":[{"database":"PubMed","id":"22864287"},{"database":"DOI","id":"10.1038/nsmb.2353"}],"title":"PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.","publicationDate":"2012","journal":"Nat. Struct. Mol. Biol.","firstPage":"916","lastPage":"924","volume":"19"},"referencePositions":["METHYLATION AT LYS-370 AND LYS-382"]},{"referenceNumber":149,"citation":{"id":"24051492","citationType":"journal article","authors":["Miki T.","Matsumoto T.","Zhao Z.","Lee C.C."],"citationCrossReferences":[{"database":"PubMed","id":"24051492"},{"database":"DOI","id":"10.1038/ncomms3444"}],"title":"p53 regulates Period2 expression and the circadian clock.","publicationDate":"2013","journal":"Nat. Commun.","firstPage":"2444","lastPage":"2444","volume":"4"},"referencePositions":["FUNCTION"]},{"referenceNumber":150,"citation":{"id":"23431171","citationType":"journal article","authors":["Rokudai S.","Laptenko O.","Arnal S.M.","Taya Y.","Kitabayashi I.","Prives C."],"citationCrossReferences":[{"database":"PubMed","id":"23431171"},{"database":"DOI","id":"10.1073/pnas.1300490110"}],"title":"MOZ increases p53 acetylation and premature senescence through its complex formation with PML.","publicationDate":"2013","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"3895","lastPage":"3900","volume":"110"},"referencePositions":["ACETYLATION AT LYS-120 AND LYS-382"]},{"referenceNumber":151,"citation":{"id":"24625977","citationType":"journal article","authors":["Sane S.","Abdullah A.","Boudreau D.A.","Autenried R.K.","Gupta B.K.","Wang X.","Wang H.","Schlenker E.H.","Zhang D.","Telleria C.","Huang L.","Chauhan S.C.","Rezvani K."],"citationCrossReferences":[{"database":"PubMed","id":"24625977"},{"database":"DOI","id":"10.1038/cddis.2014.100"}],"title":"Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.","publicationDate":"2014","journal":"Cell Death Dis.","firstPage":"e1118","lastPage":"e1118","volume":"5"},"referencePositions":["INTERACTION WITH HSPA9","SUBCELLULAR LOCATION"]},{"referenceNumber":152,"citation":{"id":"23752197","citationType":"journal article","authors":["Orre L.M.","Panizza E.","Kaminskyy V.O.","Vernet E.","Graeslund T.","Zhivotovsky B.","Lehtioe J."],"citationCrossReferences":[{"database":"PubMed","id":"23752197"},{"database":"DOI","id":"10.1038/onc.2013.213"}],"title":"S100A4 interacts with p53 in the nucleus and promotes p53 degradation.","publicationDate":"2013","journal":"Oncogene","firstPage":"5531","lastPage":"5540","volume":"32"},"referencePositions":["INTERACTION WITH S100A4","SUBCELLULAR LOCATION"]},{"referenceNumber":153,"citation":{"id":"24652652","citationType":"journal article","authors":["Polato F.","Rusconi P.","Zangrossi S.","Morelli F.","Boeri M.","Musi A.","Marchini S.","Castiglioni V.","Scanziani E.","Torri V.","Broggini M."],"citationCrossReferences":[{"database":"PubMed","id":"24652652"},{"database":"DOI","id":"10.1093/jnci/dju053"}],"title":"DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected].","publicationDate":"2014","journal":"J. Natl. Cancer Inst.","firstPage":"1","lastPage":"10","volume":"106"},"referencePositions":["FUNCTION"]},{"referenceNumber":154,"citation":{"id":"25422469","citationType":"journal article","authors":["Theng S.S.","Wang W.","Mah W.C.","Chan C.","Zhuo J.","Gao Y.","Qin H.","Lim L.","Chong S.S.","Song J.","Lee C.G."],"citationCrossReferences":[{"database":"PubMed","id":"25422469"},{"database":"DOI","id":"10.1073/pnas.1403383111"}],"title":"Disruption of FAT10-MAD2 binding inhibits tumor progression.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E5282","lastPage":"E5291","volume":"111"},"referencePositions":["INTERACTION WITH UBD"]},{"referenceNumber":155,"citation":{"id":"25168243","citationType":"journal article","authors":["Maniam S.","Coutts A.S.","Stratford M.R.","McGouran J.","Kessler B.","La Thangue N.B."],"citationCrossReferences":[{"database":"PubMed","id":"25168243"},{"database":"DOI","id":"10.1038/cdd.2014.135"}],"title":"Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.","publicationDate":"2015","journal":"Cell Death Differ.","firstPage":"156","lastPage":"163","volume":"22"},"referencePositions":["INTERACTION WITH TTC5","SUBCELLULAR LOCATION"]},{"referenceNumber":156,"citation":{"id":"26634371","citationType":"journal article","authors":["Sane S.","Abdullah A.","Nelson M.E.","Wang H.","Chauhan S.C.","Newton S.S.","Rezvani K."],"citationCrossReferences":[{"database":"PubMed","id":"26634371"},{"database":"DOI","id":"10.1007/s12192-015-0661-5"}],"title":"Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.","publicationDate":"2016","journal":"Cell Stress Chaperones","firstPage":"313","lastPage":"326","volume":"21"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":157,"citation":{"id":"25591766","citationType":"journal article","authors":["Yang L.","Zhou B.","Li X.","Lu Z.","Li W.","Huo X.","Miao Z."],"citationCrossReferences":[{"database":"PubMed","id":"25591766"},{"database":"DOI","id":"10.1159/000369691"}],"title":"RNF125 is a ubiquitin-protein ligase that promotes p53 degradation.","publicationDate":"2015","journal":"Cell. Physiol. Biochem.","firstPage":"237","lastPage":"245","volume":"35"},"referencePositions":["UBIQUITINATION"]},{"referenceNumber":158,"citation":{"id":"25772236","citationType":"journal article","authors":["Wimmer P.","Berscheminski J.","Blanchette P.","Groitl P.","Branton P.E.","Hay R.T.","Dobner T.","Schreiner S."],"citationCrossReferences":[{"database":"PubMed","id":"25772236"},{"database":"DOI","id":"10.1038/onc.2015.63"}],"title":"PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.","publicationDate":"2016","journal":"Oncogene","firstPage":"69","lastPage":"82","volume":"35"},"referencePositions":["INTERACTION WITH HADV5 E1B-55K (MICROBIAL INFECTION)"]},{"referenceNumber":159,"citation":{"id":"26868148","citationType":"journal article","authors":["Johmura Y.","Sun J.","Kitagawa K.","Nakanishi K.","Kuno T.","Naiki-Ito A.","Sawada Y.","Miyamoto T.","Okabe A.","Aburatani H.","Li S.","Miyoshi I.","Takahashi S.","Kitagawa M.","Nakanishi M."],"citationCrossReferences":[{"database":"PubMed","id":"26868148"},{"database":"DOI","id":"10.1038/ncomms10574"}],"title":"SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.","publicationDate":"2016","journal":"Nat. Commun.","firstPage":"10574","lastPage":"10574","volume":"7"},"referencePositions":["INTERACTION WITH FBXO22","UBIQUITINATION"]},{"referenceNumber":160,"citation":{"id":"27323408","citationType":"journal article","authors":["Cesnekova J.","Spacilova J.","Hansikova H.","Houstek J.","Zeman J.","Stiburek L."],"citationCrossReferences":[{"database":"PubMed","id":"27323408"},{"database":"DOI","id":"10.18632/oncotarget.9959"}],"title":"LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.","publicationDate":"2016","journal":"Oncotarget","firstPage":"47687","lastPage":"47698","volume":"7"},"referencePositions":["INTERACTION WITH AFG1L","SUBCELLULAR LOCATION"]},{"referenceNumber":161,"citation":{"id":"28842590","citationType":"journal article","authors":["Chen W.J.","Wang W.T.","Tsai T.Y.","Li H.K.","Lee Y.W."],"citationCrossReferences":[{"database":"PubMed","id":"28842590"},{"database":"DOI","id":"10.1038/s41598-017-09779-w"}],"title":"DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.","publicationDate":"2017","journal":"Sci. Rep.","firstPage":"9411","lastPage":"9411","volume":"7"},"referencePositions":["INTERACTION WITH DDX3X AND GAMMA-TUBULIN","SUBCELLULAR LOCATION","PHOSPHORYLATION AT SER-15"]},{"referenceNumber":162,"citation":{"id":"28807825","citationType":"journal article","authors":["Fu S.","Shao S.","Wang L.","Liu H.","Hou H.","Wang Y.","Wang H.","Huang X.","Lv R."],"citationCrossReferences":[{"database":"PubMed","id":"28807825"},{"database":"DOI","id":"10.1016/j.bbrc.2017.08.036"}],"title":"USP3 stabilizes p53 protein through its deubiquitinase activity.","publicationDate":"2017","journal":"Biochem. Biophys. Res. Commun.","firstPage":"178","lastPage":"183","volume":"492"},"referencePositions":["DEUBIQUITINATION BY USP3"]},{"referenceNumber":163,"citation":{"id":"33591310","citationType":"journal article","authors":["Liebl M.C.","Moehlenbrink J.","Becker H.","Raddatz G.","Abdeen S.K.","Aqeilan R.I.","Lyko F.","Hofmann T.G."],"citationCrossReferences":[{"database":"PubMed","id":"33591310"},{"database":"DOI","id":"10.1093/nar/gkab084"}],"title":"DAZAP2 acts as specifier of the p53 response to DNA damage.","publicationDate":"2021","journal":"Nucleic Acids Res.","firstPage":"2759","lastPage":"2776","volume":"49"},"referencePositions":["INTERACTION WITH DAZAP2"]},{"referenceNumber":164,"citation":{"id":"30146126","citationType":"journal article","authors":["Toki T.","Yoshida K.","Wang R.","Nakamura S.","Maekawa T.","Goi K.","Katoh M.C.","Mizuno S.","Sugiyama F.","Kanezaki R.","Uechi T.","Nakajima Y.","Sato Y.","Okuno Y.","Sato-Otsubo A.","Shiozawa Y.","Kataoka K.","Shiraishi Y.","Sanada M.","Chiba K.","Tanaka H.","Terui K.","Sato T.","Kamio T.","Sakaguchi H.","Ohga S.","Kuramitsu M.","Hamaguchi I.","Ohara A.","Kanno H.","Miyano S.","Kojima S.","Ishiguro A.","Sugita K.","Kenmochi N.","Takahashi S.","Eto K.","Ogawa S.","Ito E."],"citationCrossReferences":[{"database":"PubMed","id":"30146126"},{"database":"DOI","id":"10.1016/j.ajhg.2018.07.020"}],"title":"De novo mutations activating germline TP53 in an inherited bone-marrow-failure syndrome.","publicationDate":"2018","journal":"Am. J. Hum. Genet.","firstPage":"440","lastPage":"447","volume":"103"},"referencePositions":["INVOLVEMENT IN BMFS5"]},{"referenceNumber":165,"citation":{"id":"29681526","citationType":"journal article","authors":["Liang L.","Wang H.","Shi H.","Li Z.","Yao H.","Bu Z.","Song N.","Li C.","Xiang D.","Zhang Y.","Wang J.","Hu Y.","Xu Q.","Ma Y.","Cheng Z.","Wang Y.","Zhao S.","Qian J.","Chen Y.","Fang J.Y.","Xu J."],"citationCrossReferences":[{"database":"PubMed","id":"29681526"},{"database":"DOI","id":"10.1016/j.chembiol.2018.03.010"}],"title":"A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.","publicationDate":"2018","journal":"Cell Chem. Biol.","firstPage":"761","lastPage":"774.e5","volume":"25"},"referencePositions":["INTERACTION WITH MORN3","DEACETYLATION AT LYS-382","UBQIQUITINATION"]},{"referenceNumber":166,"citation":{"id":"29474172","citationType":"journal article","authors":["Ghosh S.","Wong S.K.","Jiang Z.","Liu B.","Wang Y.","Hao Q.","Gorbunova V.","Liu X.","Zhou Z."],"citationCrossReferences":[{"database":"PubMed","id":"29474172"},{"database":"DOI","id":"10.7554/elife.32127"}],"title":"Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.","publicationDate":"2018","journal":"Elife","firstPage":"0","lastPage":"0","volume":"7"},"referencePositions":["ACETYLATION AT LYS-381","DEACETYLATION BY SIRT6","MUTAGENESIS OF LYS-381"]},{"referenceNumber":167,"citation":{"id":"31527692","citationType":"journal article","authors":["Martin-Doncel E.","Rojas A.M.","Cantarero L.","Lazo P.A."],"citationCrossReferences":[{"database":"PubMed","id":"31527692"},{"database":"DOI","id":"10.1038/s41598-019-49821-7"}],"title":"VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes.","publicationDate":"2019","journal":"Sci. Rep.","firstPage":"13381","lastPage":"13381","volume":"9"},"referencePositions":["PHOSPHORYLATION AT THR-18 BY VRK1"]},{"referenceNumber":168,"citation":{"id":"31953488","citationType":"journal article","authors":["Kamagata K.","Kanbayashi S.","Honda M.","Itoh Y.","Takahashi H.","Kameda T.","Nagatsugi F.","Takahashi S."],"citationCrossReferences":[{"database":"PubMed","id":"31953488"},{"database":"DOI","id":"10.1038/s41598-020-57521-w"}],"title":"Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains.","publicationDate":"2020","journal":"Sci. Rep.","firstPage":"580","lastPage":"580","volume":"10"},"referencePositions":["DOMAIN","MUTAGENESIS OF SER-392"]},{"referenceNumber":169,"citation":{"id":"34523970","citationType":"journal article","authors":["Alzhanova D.","Meyo J.O.","Juarez A.","Dittmer D.P."],"citationCrossReferences":[{"database":"PubMed","id":"34523970"},{"database":"DOI","id":"10.1128/jvi.01459-21"}],"title":"The ORF45 protein of Kaposi Sarcoma-associated Herpesvirus (KSHV) is an inhibitor of p53 signaling during viral reactivation.","publicationDate":"2021","journal":"J. Virol.","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["INTERACTION WITH KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS/HHV-8 PROTEIN ORF45 (MICROBIAL INFECTION)"]},{"referenceNumber":170,"citation":{"id":"34404770","citationType":"journal article","authors":["Villot R.","Poirier A.","Bakan I.","Boulay K.","Fernandez E.","Devillers R.","Gama-Braga L.","Tribouillard L.","Gagne A.","Duchesne E.","Caron D.","Berube J.S.","Berube J.C.","Coulombe Y.","Orain M.","Gelinas Y.","Gobeil S.","Bosse Y.","Masson J.Y.","Elowe S.","Bilodeau S.","Manem V.","Joubert P.","Mallette F.A.","Laplante M."],"citationCrossReferences":[{"database":"PubMed","id":"34404770"},{"database":"DOI","id":"10.1038/s41467-021-24932-w"}],"title":"ZNF768 links oncogenic RAS to cellular senescence.","publicationDate":"2021","journal":"Nat. Commun.","firstPage":"4841","lastPage":"4841","volume":"12"},"referencePositions":["INTERACTION WITH ZNF768"]},{"referenceNumber":171,"citation":{"id":"35618207","citationType":"journal article","authors":["Dai Z.","Li G.","Chen Q.","Yang X."],"citationCrossReferences":[{"database":"PubMed","id":"35618207"},{"database":"DOI","id":"10.1016/j.bbagrm.2022.194827"}],"title":"Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.","publicationDate":"2022","journal":"Biochim. Biophys. Acta","firstPage":"194827","lastPage":"194827","volume":"1865"},"referencePositions":["FUNCTION","DOMAIN","PHOSPHORYLATION AT SER-392","MUTAGENESIS OF SER-392"]},{"referenceNumber":172,"citation":{"id":"36108750","citationType":"journal article","authors":["Chen C.","Fu G.","Guo Q.","Xue S.","Luo S.Z."],"citationCrossReferences":[{"database":"PubMed","id":"36108750"},{"database":"DOI","id":"10.1016/j.ijbiomac.2022.09.087"}],"title":"Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.","publicationDate":"2022","journal":"Int. J. Biol. Macromol.","firstPage":"207","lastPage":"216","volume":"222"},"referencePositions":["DOMAIN","SUBCELLULAR LOCATION","CHARACTERIZATION OF VARIANTS LFS CYS-337; HIS-337 AND PRO-344","CHARACTERIZATION OF VARIANT PRO-337"]},{"referenceNumber":173,"citation":{"id":"36634798","citationType":"journal article","authors":["Chen Q.","Wu Y.","Dai Z.","Zhang Z.","Yang X."],"citationCrossReferences":[{"database":"PubMed","id":"36634798"},{"database":"DOI","id":"10.1016/j.ijbiomac.2023.123221"}],"title":"Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.","publicationDate":"2023","journal":"Int. J. Biol. Macromol.","firstPage":"123221","lastPage":"123221","volume":"230"},"referencePositions":["FUNCTION","DOMAIN"]},{"referenceNumber":174,"citation":{"id":"38653238","citationType":"journal article","authors":["Zong Z.","Xie F.","Wang S.","Wu X.","Zhang Z.","Yang B.","Zhou F."],"citationCrossReferences":[{"database":"PubMed","id":"38653238"},{"database":"DOI","id":"10.1016/j.cell.2024.04.002"}],"title":"Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.","publicationDate":"2024","journal":"Cell","firstPage":"2375","lastPage":"2392","volume":"187"},"referencePositions":["FUNCTION","DOMAIN","LACTYLATION AT LYS-120 AND LYS-139","CHARACTERIZATION OF VARIANTS GLU-120; GLN-120; ASN-139; THR-139; GLN-139 AND GLU-139"]},{"referenceNumber":175,"citation":{"id":"8023159","citationType":"journal article","authors":["Clore G.M.","Omichinski J.G.","Sakaguchi K.","Zambrano N.","Sakamoto H.","Appella E.","Gronenborn A.M."],"citationCrossReferences":[{"database":"PubMed","id":"8023159"},{"database":"DOI","id":"10.1126/science.8023159"}],"title":"High-resolution structure of the oligomerization domain of p53 by multidimensional NMR.","publicationDate":"1994","journal":"Science","firstPage":"386","lastPage":"391","volume":"265"},"referencePositions":["STRUCTURE BY NMR OF 319-360"]},{"referenceNumber":176,"citation":{"id":"7773777","citationType":"journal article","authors":["Lee W.","Harvey T.S.","Yin Y.","Yau P.","Litchfield D.","Arrowsmith C.H."],"citationCrossReferences":[{"database":"PubMed","id":"7773777"},{"database":"DOI","id":"10.1038/nsb1294-877"}],"title":"Solution structure of the tetrameric minimum transforming domain of p53.","publicationDate":"1994","journal":"Nat. Struct. Biol.","firstPage":"877","lastPage":"890","volume":"1"},"referencePositions":["STRUCTURE BY NMR OF 325-355"]},{"referenceNumber":177,"citation":{"id":"9321402","citationType":"journal article","authors":["McCoy M.","Stavridi E.S.","Waterman J.L.","Wieczorek A.M.","Opella S.J.","Halazonetis T.D."],"citationCrossReferences":[{"database":"PubMed","id":"9321402"},{"database":"DOI","id":"10.1093/emboj/16.20.6230"}],"title":"Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain.","publicationDate":"1997","journal":"EMBO J.","firstPage":"6230","lastPage":"6236","volume":"16"},"referencePositions":["STRUCTURE BY NMR OF 326-354"]},{"referenceNumber":178,"citation":{"id":"8023157","citationType":"journal article","authors":["Cho Y.","Gorina S.","Jeffrey P.D.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"8023157"},{"database":"DOI","id":"10.1126/science.8023157"}],"title":"Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.","publicationDate":"1994","journal":"Science","firstPage":"346","lastPage":"355","volume":"265"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 94-289"]},{"referenceNumber":179,"citation":{"id":"7878469","citationType":"journal article","authors":["Jeffrey P.D.","Gorina S.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"7878469"},{"database":"DOI","id":"10.1126/science.7878469"}],"title":"Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms.","publicationDate":"1995","journal":"Science","firstPage":"1498","lastPage":"1502","volume":"267"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 325-356"]},{"referenceNumber":180,"citation":{"id":"8875929","citationType":"journal article","authors":["Kussie P.H.","Gorina S.","Marechal V.","Elenbaas B.","Moreau J.","Levine A.J.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"8875929"},{"database":"DOI","id":"10.1126/science.274.5289.948"}],"title":"Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.","publicationDate":"1996","journal":"Science","firstPage":"948","lastPage":"953","volume":"274"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 13-29 IN COMPLEX WITH MDM2"]},{"referenceNumber":181,"citation":{"id":"8875926","citationType":"journal article","authors":["Gorina S.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"8875926"},{"database":"DOI","id":"10.1126/science.274.5289.1001"}],"title":"Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.","publicationDate":"1996","journal":"Science","firstPage":"1001","lastPage":"1005","volume":"274"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 97-287 IN COMPLEX WITH 53BP2"]},{"referenceNumber":182,"citation":{"id":"14534297","citationType":"journal article","authors":["Joerger A.C.","Allen M.D.","Fersht A.R."],"citationCrossReferences":[{"database":"PubMed","id":"14534297"},{"database":"DOI","id":"10.1074/jbc.m309732200"}],"title":"Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"1291","lastPage":"1296","volume":"279"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 94-312 IN COMPLEX WITH ZINC IONS","SUBUNIT"]},{"referenceNumber":183,"citation":{"id":"16793544","citationType":"journal article","authors":["Kitayner M.","Rozenberg H.","Kessler N.","Rabinovich D.","Shaulov L.","Haran T.E.","Shakked Z."],"citationCrossReferences":[{"database":"PubMed","id":"16793544"},{"database":"DOI","id":"10.1016/j.molcel.2006.05.015"}],"title":"Structural basis of DNA recognition by p53 tetramers.","publicationDate":"2006","journal":"Mol. Cell","firstPage":"741","lastPage":"753","volume":"22"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 94-293 IN COMPLEX WITH DNA AND ZINC IONS","SUBUNIT"]},{"referenceNumber":184,"citation":{"id":"16474402","citationType":"journal article","authors":["Sheng Y.","Saridakis V.","Sarkari F.","Duan S.","Wu T.","Arrowsmith C.H.","Frappier L."],"citationCrossReferences":[{"database":"PubMed","id":"16474402"},{"database":"DOI","id":"10.1038/nsmb1067"}],"title":"Molecular recognition of p53 and MDM2 by USP7/HAUSP.","publicationDate":"2006","journal":"Nat. Struct. Mol. Biol.","firstPage":"285","lastPage":"291","volume":"13"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 358-367 IN COMPLEX WITH USP7","INTERACTION WITH USP7"]},{"referenceNumber":185,"citation":{"id":"16402859","citationType":"journal article","authors":["Hu M.","Gu L.","Li M.","Jeffrey P.D.","Gu W.","Shi Y."],"citationCrossReferences":[{"database":"PubMed","id":"16402859"},{"database":"DOI","id":"10.1371/journal.pbio.0040027"}],"title":"Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.","publicationDate":"2006","journal":"PLoS Biol.","firstPage":"228","lastPage":"239","volume":"4"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 360-368 IN COMPLEX WITH USP7","MUTAGENESIS OF PRO-359; GLY-361 AND SER-362","INTERACTION WITH USP7"]},{"referenceNumber":186,"citation":{"id":"20870725","citationType":"journal article","authors":["West L.E.","Roy S.","Lachmi-Weiner K.","Hayashi R.","Shi X.","Appella E.","Kutateladze T.G.","Gozani O."],"citationCrossReferences":[{"database":"PubMed","id":"20870725"},{"database":"DOI","id":"10.1074/jbc.m110.139527"}],"title":"The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"37725","lastPage":"37732","volume":"285"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 377-386","METHYLATION AT LYS-382","MUTAGENESIS OF LYS-382","INTERACTION WITH L3MBTL1"]},{"referenceNumber":187,"citation":{"id":"8266092","citationType":"journal article","authors":["Harris C.C."],"citationCrossReferences":[{"database":"PubMed","id":"8266092"},{"database":"DOI","id":"10.1126/science.8266092"}],"title":"p53: at the crossroads of molecular carcinogenesis and risk assessment.","publicationDate":"1993","journal":"Science","firstPage":"1980","lastPage":"1981","volume":"262"},"referencePositions":["REVIEW"]},{"referenceNumber":188,"citation":{"id":"1905840","citationType":"journal article","authors":["Hoolstein M.","Sidransky D.","Vogelstein B.","Harris C.C."],"citationCrossReferences":[{"database":"PubMed","id":"1905840"},{"database":"DOI","id":"10.1126/science.1905840"}],"title":"p53 mutations in human cancers.","publicationDate":"1991","journal":"Science","firstPage":"49","lastPage":"53","volume":"253"},"referencePositions":["REVIEW ON VARIANTS"]},{"referenceNumber":189,"citation":{"id":"8829653","citationType":"journal article","authors":["de Vries E.M.G.","Ricke D.O.","de Vries T.N.","Hartmann A.","Blaszyk H.","Liao D.","Soussi T.","Kovach J.S.","Sommer S.S."],"citationCrossReferences":[{"database":"PubMed","id":"8829653"},{"database":"DOI","id":"10.1002/(sici)1098-1004(1996)7:3<202::aid-humu4>3.0.co;2-c"}],"title":"Database of mutations in the p53 and APC tumor suppressor genes designed to facilitate molecular epidemiological analyses.","publicationDate":"1996","journal":"Hum. Mutat.","firstPage":"202","lastPage":"213","volume":"7"},"referencePositions":["REVIEW ON VARIANTS"]},{"referenceNumber":190,"citation":{"id":"17015838","citationType":"journal article","authors":["Joerger A.C.","Ang H.C.","Fersht A.R."],"citationCrossReferences":[{"database":"PubMed","id":"17015838"},{"database":"DOI","id":"10.1073/pnas.0607286103"}],"title":"Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15056","lastPage":"15061","volume":"103"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 94-312 IN COMPLEX WITH ZINC IONS"]},{"referenceNumber":191,"citation":{"id":"18453682","citationType":"journal article","authors":["Tu C.","Tan Y.H.","Shaw G.","Zhou Z.","Bai Y.","Luo R.","Ji X."],"citationCrossReferences":[{"database":"PubMed","id":"18453682"},{"database":"DOI","id":"10.1107/s0907444908003338"}],"title":"Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 angstroms resolution.","publicationDate":"2008","journal":"Acta Crystallogr. D","firstPage":"471","lastPage":"477","volume":"64"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 94-292 OF VARIANT GLN-282"]},{"referenceNumber":192,"citation":{"id":"18650397","citationType":"journal article","authors":["Boeckler F.M.","Joerger A.C.","Jaggi G.","Rutherford T.J.","Veprintsev D.B.","Fersht A.R."],"citationCrossReferences":[{"database":"PubMed","id":"18650397"},{"database":"DOI","id":"10.1073/pnas.0805326105"}],"title":"Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10360","lastPage":"10365","volume":"105"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 94-312 OF VARIANT CYS-202 IN COMPLEX WITH ZINC IONS AND PHIKAN083"]},{"referenceNumber":193,"citation":{"id":"18996393","citationType":"journal article","authors":["Suad O.","Rozenberg H.","Brosh R.","Diskin-Posner Y.","Kessler N.","Shimon L.J.","Frolow F.","Liran A.","Rotter V.","Shakked Z."],"citationCrossReferences":[{"database":"PubMed","id":"18996393"},{"database":"DOI","id":"10.1016/j.jmb.2008.10.063"}],"title":"Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations.","publicationDate":"2009","journal":"J. Mol. Biol.","firstPage":"249","lastPage":"265","volume":"385"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 94-293 OF VARIANT SER-249 IN COMPLEX WITH DNA"]},{"referenceNumber":194,"citation":{"id":"19515728","citationType":"journal article","authors":["Khoo K.H.","Joerger A.C.","Freund S.M.","Fersht A.R."],"citationCrossReferences":[{"database":"PubMed","id":"19515728"},{"database":"DOI","id":"10.1093/protein/gzp018"}],"title":"Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.","publicationDate":"2009","journal":"Protein Eng. Des. Sel.","firstPage":"421","lastPage":"430","volume":"22"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 94-310 IN COMPLEX WITH ZINC IONS"]},{"referenceNumber":195,"citation":{"id":"20142040","citationType":"journal article","authors":["Basse N.","Kaar J.L.","Settanni G.","Joerger A.C.","Rutherford T.J.","Fersht A.R."],"citationCrossReferences":[{"database":"PubMed","id":"20142040"},{"database":"DOI","id":"10.1016/j.chembiol.2009.12.011"}],"title":"Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant.","publicationDate":"2010","journal":"Chem. Biol.","firstPage":"46","lastPage":"56","volume":"17"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 94-312 OF VARIANT CYS-220 IN COMPLEX WITH ZINC IONS"]},{"referenceNumber":196,"citation":{"id":"20364130","citationType":"journal article","authors":["Kitayner M.","Rozenberg H.","Rohs R.","Suad O.","Rabinovich D.","Honig B.","Shakked Z."],"citationCrossReferences":[{"database":"PubMed","id":"20364130"},{"database":"DOI","id":"10.1038/nsmb.1800"}],"title":"Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.","publicationDate":"2010","journal":"Nat. Struct. Mol. Biol.","firstPage":"423","lastPage":"429","volume":"17"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 94-293 IN COMPLEX WITH DNA AND ZINC IONS","SUBUNIT"]},{"referenceNumber":197,"citation":{"id":"32442400","citationType":"journal article","authors":["Ecsedi P.","Gogl G.","Hof H.","Kiss B.","Harmat V.","Nyitray L."],"citationCrossReferences":[{"database":"PubMed","id":"32442400"},{"database":"DOI","id":"10.1016/j.str.2020.05.001"}],"title":"Structure Determination of the Transactivation Domain of p53 in Complex with S100A4Using Annexin A2 as a Crystallization Chaperone.","publicationDate":"2020","journal":"Structure","firstPage":"943","lastPage":"953.e4","volume":"28"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 17-56","INTERACTION WITH S100A4"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6T58"}]},{"referenceNumber":198,"citation":{"id":"1999338","citationType":"journal article","authors":["Olschwang S.","Laurent-Puig P.","Vassal A.","Salmon R.-J.","Thomas G."],"citationCrossReferences":[{"database":"PubMed","id":"1999338"},{"database":"DOI","id":"10.1007/bf00201836"}],"title":"Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population.","publicationDate":"1991","journal":"Hum. Genet.","firstPage":"369","lastPage":"370","volume":"86"},"referencePositions":["VARIANT ARG-72"]},{"referenceNumber":199,"citation":{"id":"1933902","citationType":"journal article","authors":["Law J.C.","Strong L.C.","Chidambaram A.","Ferrell R.E."],"citationCrossReferences":[{"database":"PubMed","id":"1933902"}],"title":"A germ line mutation in exon 5 of the p53 gene in an extended cancer family.","publicationDate":"1991","journal":"Cancer Res.","firstPage":"6385","lastPage":"6387","volume":"51"},"referencePositions":["VARIANT LFS THR-133"]},{"referenceNumber":200,"citation":{"id":"1978757","citationType":"journal article","authors":["Malkin D.","Li F.P.","Strong L.C.","Fraumeni J.F. Jr.","Nelson C.E.","Kim D.H.","Kassel J.","Gryka M.A.","Bischoff F.Z.","Tainsky M.A.","Friend S.H."],"citationCrossReferences":[{"database":"PubMed","id":"1978757"},{"database":"DOI","id":"10.1126/science.1978757"}],"title":"Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.","publicationDate":"1990","journal":"Science","firstPage":"1233","lastPage":"1238","volume":"250"},"referencePositions":["VARIANTS LFS CYS-245; TRP-248; PRO-252 AND LYS-258"]},{"referenceNumber":201,"citation":{"id":"2259385","citationType":"journal article","authors":["Srivastava S.","Zou Z.","Pirollo K.","Blattner W.","Chang E.H."],"citationCrossReferences":[{"database":"PubMed","id":"2259385"},{"database":"DOI","id":"10.1038/348747a0"}],"title":"Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.","publicationDate":"1990","journal":"Nature","firstPage":"747","lastPage":"749","volume":"348"},"referencePositions":["VARIANT LFS ASP-245"]},{"referenceNumber":202,"citation":{"id":"1737852","citationType":"journal article","authors":["Felix C.A.","Nau M.M.","Takahashi T.","Mitsudomi T.","Chiba I.","Poplack D.G.","Reaman G.H.","Cole D.E.","Letterio J.J.","Whang-Peng J.","Knutsen T.","Minna J.D."],"citationCrossReferences":[{"database":"PubMed","id":"1737852"},{"database":"DOI","id":"10.1172/jci115630"}],"title":"Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.","publicationDate":"1992","journal":"J. Clin. Invest.","firstPage":"640","lastPage":"647","volume":"89"},"referencePositions":["VARIANT LFS LEU-272"]},{"referenceNumber":203,"citation":{"id":"1565144","citationType":"journal article","authors":["Malkin D.","Jolly K.W.","Barbier N.","Look A.T.","Friend S.H.","Gebhardt M.C.","Andersen T.I.","Boerresen A.-L.","Li F.P.","Garber J.","Strong L.C."],"citationCrossReferences":[{"database":"PubMed","id":"1565144"},{"database":"DOI","id":"10.1056/nejm199205143262002"}],"title":"Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.","publicationDate":"1992","journal":"N. Engl. J. Med.","firstPage":"1309","lastPage":"1315","volume":"326"},"referencePositions":["VARIANTS LFS HIS-273 AND VAL-325"]},{"referenceNumber":204,"citation":{"id":"1694291","citationType":"journal article","authors":["Bartek J.","Iggo R.","Gannon J.","Lane D.P."],"citationCrossReferences":[{"database":"PubMed","id":"1694291"}],"title":"Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.","publicationDate":"1990","journal":"Oncogene","firstPage":"893","lastPage":"899","volume":"5"},"referencePositions":["VARIANTS SPORADIC CANCERS GLN-132; SER-249; LYS-280 AND LYS-285"]},{"referenceNumber":205,"citation":{"id":"1699228","citationType":"journal article","authors":["Rodrigues N.R.","Rowan A.","Smith M.E.F.","Kerr I.B.","Bodmer W.F.","Gannon J.V.","Lane D.P."],"citationCrossReferences":[{"database":"PubMed","id":"1699228"},{"database":"DOI","id":"10.1073/pnas.87.19.7555"}],"title":"p53 mutations in colorectal cancer.","publicationDate":"1990","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7555","lastPage":"7559","volume":"87"},"referencePositions":["VARIANTS SPORADIC CANCERS PHE-241 AND HIS-273"]},{"referenceNumber":206,"citation":{"id":"2263646","citationType":"journal article","authors":["Hollstein M.C.","Metcalf R.A.","Welsh J.A.","Montesano R.","Harris C.C."],"citationCrossReferences":[{"database":"PubMed","id":"2263646"},{"database":"DOI","id":"10.1073/pnas.87.24.9958"}],"title":"Frequent mutation of the p53 gene in human esophageal cancer.","publicationDate":"1990","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9958","lastPage":"9961","volume":"87"},"referencePositions":["VARIANTS SPORADIC CANCER VAL-154; VAL-245; GLN-248; LEU-278 AND SER-278"]},{"referenceNumber":207,"citation":{"id":"1647768","citationType":"journal article","authors":["Ishioka C.","Sato T.","Gamoh M.","Suzuki T.","Shibata H.","Kanamaru R.","Wakui A.","Yamazaki T."],"citationCrossReferences":[{"database":"PubMed","id":"1647768"},{"database":"DOI","id":"10.1016/0006-291x(91)90623-f"}],"title":"Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors.","publicationDate":"1991","journal":"Biochem. Biophys. Res. Commun.","firstPage":"901","lastPage":"906","volume":"177"},"referencePositions":["VARIANTS SPORADIC CANCERS"]},{"referenceNumber":208,"citation":{"id":"1868473","citationType":"journal article","authors":["Casson A.G.","Mukhopadhyay T.","Cleary K.R.","Ro J.Y.","Levin B.","Roth J.A."],"citationCrossReferences":[{"database":"PubMed","id":"1868473"}],"title":"p53 gene mutations in Barrett's epithelium and esophageal cancer.","publicationDate":"1991","journal":"Cancer Res.","firstPage":"4495","lastPage":"4499","volume":"51"},"referencePositions":["VARIANTS SPORADIC CANCERS LEU-152; ALA-155; HIS-175; PHE-176 AND HIS-273"]},{"referenceNumber":209,"citation":{"id":"1849234","citationType":"journal article","authors":["Hsu I.C.","Metcalf R.A.","Sun T.","Welsh J.A.","Wang N.J.","Harris C.C."],"citationCrossReferences":[{"database":"PubMed","id":"1849234"},{"database":"DOI","id":"10.1038/350427a0"}],"title":"Mutational hotspot in the p53 gene in human hepatocellular carcinomas.","publicationDate":"1991","journal":"Nature","firstPage":"427","lastPage":"428","volume":"350"},"referencePositions":["VARIANTS SPORADIC CANCERS IN CHINA"]},{"referenceNumber":210,"citation":{"id":"1672732","citationType":"journal article","authors":["Bressac B.","Kew M.","Wands J.","Ozturk M."],"citationCrossReferences":[{"database":"PubMed","id":"1672732"},{"database":"DOI","id":"10.1038/350429a0"}],"title":"Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa.","publicationDate":"1991","journal":"Nature","firstPage":"429","lastPage":"431","volume":"350"},"referencePositions":["VARIANTS SPORADIC CANCERS IN SOUTH AFRICA"]},{"referenceNumber":211,"citation":{"id":"1394225","citationType":"journal article","authors":["Somers K.D.","Merrick M.A.","Lopez M.E.","Incognito L.S.","Schechter G.L.","Casey G."],"citationCrossReferences":[{"database":"PubMed","id":"1394225"}],"title":"Frequent p53 mutations in head and neck cancer.","publicationDate":"1992","journal":"Cancer Res.","firstPage":"5997","lastPage":"6000","volume":"52"},"referencePositions":["VARIANTS SPORADIC CANCERS PHE-176; PHE-242; CYS-245; LEU-248 AND HIS-273"]},{"referenceNumber":212,"citation":{"id":"1327751","citationType":"journal article","authors":["Crook T.","Vousden K.H."],"citationCrossReferences":[{"database":"PubMed","id":"1327751"},{"database":"DOI","id":"10.1002/j.1460-2075.1992.tb05487.x"}],"title":"Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.","publicationDate":"1992","journal":"EMBO J.","firstPage":"3935","lastPage":"3940","volume":"11"},"referencePositions":["VARIANTS SPORADIC CANCERS"]},{"referenceNumber":213,"citation":{"id":"1459726","citationType":"journal article","authors":["Sakai E.","Rikimaru K.","Ueda M.","Matsumoto Y.","Ishii N.","Enomoto S.","Yamamoto H.","Tsuchida N."],"citationCrossReferences":[{"database":"PubMed","id":"1459726"},{"database":"DOI","id":"10.1002/ijc.2910520606"}],"title":"The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.","publicationDate":"1992","journal":"Int. J. Cancer","firstPage":"867","lastPage":"872","volume":"52"},"referencePositions":["VARIANTS SPORADIC CANCERS CYS-205; GLU-281 AND LYS-285"]},{"referenceNumber":214,"citation":{"id":"1303181","citationType":"journal article","authors":["Bhatia K.","Guiterrez M.I.","Magrath I.T."],"citationCrossReferences":[{"database":"PubMed","id":"1303181"},{"database":"DOI","id":"10.1093/hmg/1.3.207"}],"title":"A novel mutation in the p53 gene in a Burkitt's lymphoma cell line.","publicationDate":"1992","journal":"Hum. Mol. Genet.","firstPage":"207","lastPage":"208","volume":"1"},"referencePositions":["VARIANT PRO-HIS-PRO-178 INS"]},{"referenceNumber":215,"citation":{"id":"1437144","citationType":"journal article","authors":["Duthu A.","Debuire B.","Romano J.W.","Ehrhart J.C.","Fiscella M.","May E.","Appella E.","May P."],"citationCrossReferences":[{"database":"PubMed","id":"1437144"}],"title":"p53 mutations in Raji cells: characterization and localization relative to other Burkitt's lymphomas.","publicationDate":"1992","journal":"Oncogene","firstPage":"2161","lastPage":"2167","volume":"7"},"referencePositions":["VARIANTS SPORADIC CANCERS"]},{"referenceNumber":216,"citation":{"id":"1631151","citationType":"journal article","authors":["Sun Y.","Hegamyer G.","Heng Y.-J.","Hildesheim A.","Chen J.-Y.","Chen I.-H.","Cao Y.","Yao K.-T.","Colburn N.H."],"citationCrossReferences":[{"database":"PubMed","id":"1631151"},{"database":"DOI","id":"10.1073/pnas.89.14.6516"}],"title":"An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6516","lastPage":"6520","volume":"89"},"referencePositions":["VARIANT SPORADIC CANCER THR-280"]},{"referenceNumber":217,"citation":{"id":"7682763","citationType":"journal article","authors":["Caamano J.","Zhang S.Y.","Rosvold E.A.","Bauer B.","Klein-Szanto A.J.P."],"citationCrossReferences":[{"database":"PubMed","id":"7682763"}],"title":"p53 alterations in human squamous cell carcinomas and carcinoma cell lines.","publicationDate":"1993","journal":"Am. J. Pathol.","firstPage":"1131","lastPage":"1139","volume":"142"},"referencePositions":["VARIANTS SPORADIC CANCERS SER-151; PRO-156; LYS-174; ARG-194; CYS-220; GLN-248; LEU-248 AND HIS-273"]},{"referenceNumber":218,"citation":{"id":"8402617","citationType":"journal article","authors":["Boyle J.O.","Hakim J.","Koch W.","van der Riet P.","Hruban R.H.","Roa R.A.","Correo R.","Eby Y.J.","Ruppert J.M.","Sidransky D."],"citationCrossReferences":[{"database":"PubMed","id":"8402617"}],"title":"The incidence of p53 mutations increases with progression of head and neck cancer.","publicationDate":"1993","journal":"Cancer Res.","firstPage":"4477","lastPage":"4480","volume":"53"},"referencePositions":["VARIANTS SPORADIC CANCERS"]},{"referenceNumber":219,"citation":{"id":"8336944","citationType":"journal article","authors":["Hamelin R.","Jego N.","Laurent-Puig P.","Vidaud M.","Thomas G."],"citationCrossReferences":[{"database":"PubMed","id":"8336944"}],"title":"Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors.","publicationDate":"1993","journal":"Oncogene","firstPage":"2213","lastPage":"2220","volume":"8"},"referencePositions":["VARIANTS SPORADIC CANCERS"]},{"referenceNumber":220,"citation":{"id":"8118819","citationType":"journal article","authors":["Birch J.M.","Hartley A.L.","Tricker K.J.","Prosser J.","Condie A.","Kelsey A.M.","Harris M.","Jones P.H.","Binchy A.","Crowther D.","Craft A.W.","Eden O.B.","Evans D.G.R.","Thompson E.","Mann J.R.","Martin J.","Mitchell E.L.D.","Santibanez-Koref M.F."],"citationCrossReferences":[{"database":"PubMed","id":"8118819"}],"title":"Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.","publicationDate":"1994","journal":"Cancer Res.","firstPage":"1298","lastPage":"1304","volume":"54"},"referencePositions":["VARIANTS","INVOLVEMENT IN LFL"]},{"referenceNumber":221,"citation":{"id":"8013454","citationType":"journal article","authors":["Zhang W.","Guo X.-Y.","Hu G.-Y.","Liu W.-B.","Shay J.W.","Deisseroth A.B."],"citationCrossReferences":[{"database":"PubMed","id":"8013454"},{"database":"DOI","id":"10.1002/j.1460-2075.1994.tb06543.x"}],"title":"A temperature-sensitive mutant of human p53.","publicationDate":"1994","journal":"EMBO J.","firstPage":"2535","lastPage":"2544","volume":"13"},"referencePositions":["CHARACTERIZATION OF VARIANT ALA-143"]},{"referenceNumber":222,"citation":{"id":"7887414","citationType":"journal article","authors":["Frebourg T.","Barbier N.","Yan Y.-X.","Garber J.E.","Dreyfus M.","Fraumeni J.F. Jr.","Li F.P.","Friend S.H."],"citationCrossReferences":[{"database":"PubMed","id":"7887414"}],"title":"Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.","publicationDate":"1995","journal":"Am. J. Hum. Genet.","firstPage":"608","lastPage":"615","volume":"56"},"referencePositions":["VARIANTS LFS HIS-175; ARG-193; GLN-248; CYS-273 AND TYR-275"]},{"referenceNumber":223,"citation":{"id":"8718514","citationType":"journal article","authors":["Eeles R.A."],"citationCrossReferences":[{"database":"PubMed","id":"8718514"}],"title":"Germline mutations in the TP53 gene.","publicationDate":"1995","journal":"Cancer Surv.","firstPage":"101","lastPage":"124","volume":"25"},"referencePositions":["VARIANTS","INVOLVEMENT IN LFL"]},{"referenceNumber":224,"citation":{"id":"8825920","citationType":"journal article","authors":["Varley J.M.","McGrown G.","Thorncroft M.","Tricker K.J.","Teare M.D.","Santibanez-Koref M.F.","Houlston R.S.","Martin J.","Birch J.M.","Evans D.G.R."],"citationCrossReferences":[{"database":"PubMed","id":"8825920"},{"database":"DOI","id":"10.1136/jmg.32.12.942"}],"title":"An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.","publicationDate":"1995","journal":"J. Med. Genet.","firstPage":"942","lastPage":"945","volume":"32"},"referencePositions":["VARIANT LFS HIS-175"]},{"referenceNumber":225,"citation":{"id":"8829627","citationType":"journal article","authors":["Audrezet M.-P.","Robaszkiewicz M.","Mercier B.","Nousbaum J.-B.","Hardy E.","Bail J.-P.","Volant A.","Lozac'H P.","Gouerou H.","Ferec C."],"citationCrossReferences":[{"database":"PubMed","id":"8829627"},{"database":"DOI","id":"10.1002/(sici)1098-1004(1996)7:2<109::aid-humu4>3.0.co;2-7"}],"title":"Molecular analysis of the TP53 gene in Barrett's adenocarcinoma.","publicationDate":"1996","journal":"Hum. Mutat.","firstPage":"109","lastPage":"113","volume":"7"},"referencePositions":["VARIANTS SPORADIC CANCERS PHE-176; SER-245; TRP-248; TRP-282 AND GLN-286"]},{"referenceNumber":226,"citation":{"id":"9101296","citationType":"journal article","authors":["Guldberg P.","Nedergaard T.","Nielsen H.J.","Olsen A.C.","Ahrenkiel V.","Zeuthen J."],"citationCrossReferences":[{"database":"PubMed","id":"9101296"},{"database":"DOI","id":"10.1002/(sici)1098-1004(1997)9:4<348::aid-humu8>3.0.co;2-1"}],"title":"Single-step DGGE-based mutation scanning of the p53 gene: application to genetic diagnosis of colorectal cancer.","publicationDate":"1997","journal":"Hum. Mutat.","firstPage":"348","lastPage":"355","volume":"9"},"referencePositions":["VARIANTS SPORADIC CANCERS"]},{"referenceNumber":227,"citation":{"id":"9419979","citationType":"journal article","authors":["Miyaki M.","Nishio J.","Konishi M.","Kikuchi-Yanoshita R.","Tanaka K.","Muraoka M.","Nagato M.","Chong J.-M.","Koike M.","Terada T.","Kawahara Y.","Fukutome A.","Tomiyama J.","Chuganji Y.","Momoi M.","Utsunomiya J."],"citationCrossReferences":[{"database":"PubMed","id":"9419979"},{"database":"DOI","id":"10.1038/sj.onc.1201668"}],"title":"Drastic genetic instability of tumors and normal tissues in Turcot syndrome.","publicationDate":"1997","journal":"Oncogene","firstPage":"2877","lastPage":"2881","volume":"15"},"referencePositions":["VARIANT SPORADIC CANCER ILE-157"]},{"referenceNumber":228,"citation":{"id":"9450901","citationType":"journal article","authors":["van Rensburg E.J.","Engelbrecht S.","van Heerden W.F.P.","Kotze M.J.","Raubenheimer E.J."],"citationCrossReferences":[{"database":"PubMed","id":"9450901"},{"database":"DOI","id":"10.1002/(sici)1098-1004(1998)11:1<39::aid-humu6>3.0.co;2-g"}],"title":"Detection of p53 gene mutations in oral squamous cell carcinomas of a black African population sample.","publicationDate":"1998","journal":"Hum. Mutat.","firstPage":"39","lastPage":"44","volume":"11"},"referencePositions":["VARIANTS SER-152; ILE-169; PHE-176; THR-195; CYS-220; ILE-230; CYS-273 AND SER-278"]},{"referenceNumber":229,"citation":{"id":"9452042","citationType":"journal article","authors":["Luca J.W.","Strong L.C.","Hansen M.F."],"citationCrossReferences":[{"database":"PubMed","id":"9452042"},{"database":"DOI","id":"10.1002/humu.1380110121"}],"title":"A germline missense mutation R337C in exon 10 of the human p53 gene.","publicationDate":"1998","journal":"Hum. Mutat. Suppl.","firstPage":"S58","lastPage":"S61","volume":"1"},"referencePositions":["VARIANT NON-CLASSICAL LFS CYS-337"]},{"referenceNumber":230,"citation":{"id":"10484981","citationType":"journal article","authors":["Gueran S.","Tunca Y.","Imirzalioglu N."],"citationCrossReferences":[{"database":"PubMed","id":"10484981"},{"database":"DOI","id":"10.1016/s0165-4608(98)00276-3"}],"title":"Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.","publicationDate":"1999","journal":"Cancer Genet. Cytogenet.","firstPage":"145","lastPage":"151","volume":"113"},"referencePositions":["VARIANT LFS ILE-292"]},{"referenceNumber":231,"citation":{"id":"10549356","citationType":"journal article","authors":["Hainaut P.","Hollstein M."],"citationCrossReferences":[{"database":"PubMed","id":"10549356"},{"database":"DOI","id":"10.1016/s0065-230x(08)60785-x"}],"title":"p53 and human cancer: the first ten thousand mutations.","publicationDate":"2000","journal":"Adv. Cancer Res.","firstPage":"81","lastPage":"137","volume":"77"},"referencePositions":["VARIANTS"]},{"referenceNumber":232,"citation":{"id":"11481490","citationType":"journal article","authors":["Ribeiro R.C.","Sandrini F.","Figueiredo B.","Zambetti G.P.","Michalkiewicz E.","Lafferty A.R.","DeLacerda L.","Rabin M.","Cadwell C.","Sampaio G.","Cat I.","Stratakis C.A.","Sandrini R."],"citationCrossReferences":[{"database":"PubMed","id":"11481490"},{"database":"DOI","id":"10.1073/pnas.161479898"}],"title":"An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.","publicationDate":"2001","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9330","lastPage":"9335","volume":"98"},"referencePositions":["VARIANT ADCC HIS-337"]},{"referenceNumber":233,"citation":{"id":"12085209","citationType":"journal article","authors":["Rutherford J.","Chu C.E.","Duddy P.M.","Charlton R.S.","Chumas P.","Taylor G.R.","Lu X.","Barnes D.M.","Camplejohn R.S."],"citationCrossReferences":[{"database":"PubMed","id":"12085209"},{"database":"DOI","id":"10.1038/sj.bjc.6600269"}],"title":"Investigations on a clinically and functionally unusual and novel germline p53 mutation.","publicationDate":"2002","journal":"Br. J. Cancer","firstPage":"1592","lastPage":"1596","volume":"86"},"referencePositions":["INVOLVEMENT IN CPP"]},{"referenceNumber":234,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANTS [LARGE SCALE ANALYSIS] LEU-134; PHE-157; CYS-163; HIS-175; ARG-177; ARG-193; PRO-213; PHE-241; PHE-242; GLN-248; TRP-248; SER-249; TRP-267; LYS-271; CYS-273; HIS-273; LEU-273; SER-278; ILE-280 AND HIS-281"]},{"referenceNumber":235,"citation":{"id":"17224074","citationType":"journal article","authors":["Chanock S.J.","Burdett L.","Yeager M.","Llaca V.","Langeroed A.","Presswalla S.","Kaaresen R.","Strausberg R.L.","Gerhard D.S.","Kristensen V.","Perou C.M.","Boerresen-Dale A.-L."],"citationCrossReferences":[{"database":"PubMed","id":"17224074"},{"database":"DOI","id":"10.1186/bcr1637"}],"title":"Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.","publicationDate":"2007","journal":"Breast Cancer Res.","firstPage":"R5","lastPage":"R5","volume":"9"},"referencePositions":["VARIANTS PRO-110; VAL-113; VAL-138; CYS-163; HIS-163; THR-195; MET-216; ALA-241; MET-249; SER-251; TYR-259 AND CYS-273"]},{"referenceNumber":236,"citation":{"id":"17311302","citationType":"journal article","authors":["Petitjean A.","Mathe E.","Kato S.","Ishioka C.","Tavtigian S.V.","Hainaut P.","Olivier M."],"citationCrossReferences":[{"database":"PubMed","id":"17311302"},{"database":"DOI","id":"10.1002/humu.20495"}],"title":"Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.","publicationDate":"2007","journal":"Hum. Mutat.","firstPage":"622","lastPage":"629","volume":"28"},"referencePositions":["VARIANTS"]},{"referenceNumber":237,"citation":{"id":"25732823","citationType":"journal article","authors":["Qin B.","Minter-Dykhouse K.","Yu J.","Zhang J.","Liu T.","Zhang H.","Lee S.","Kim J.","Wang L.","Lou Z."],"citationCrossReferences":[{"database":"PubMed","id":"25732823"},{"database":"DOI","id":"10.1016/j.celrep.2015.01.066"}],"title":"DBC1 functions as a tumor suppressor by regulating p53 stability.","publicationDate":"2015","journal":"Cell Rep.","firstPage":"1324","lastPage":"1334","volume":"10"},"referencePositions":["CHARACTERIZATION OF VARIANT SPORADIC CANCER LYS-280","UBIQUITINATION","PROTEASOMAL DEGRADATION","INTERACTION WITH CCAR2"]},{"referenceNumber":238,"citation":{"id":"27657329","citationType":"journal article","authors":["Guan Y.","Huang D.","Chen F.","Gao C.","Tao T.","Shi H.","Zhao S.","Liao Z.","Lo L.J.","Wang Y.","Chen J.","Peng J."],"citationCrossReferences":[{"database":"PubMed","id":"27657329"},{"database":"DOI","id":"10.1371/journal.pbio.1002555"}],"title":"Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.","publicationDate":"2016","journal":"PLoS Biol.","firstPage":"e1002555","lastPage":"e1002555","volume":"14"},"referencePositions":["VARIANTS VAL-138; HIS-175; ILE-237; TRP-248 AND PRO-273"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X02469","properties":[{"key":"ProteinId","value":"CAA26306.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M13121","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13112","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13113","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13114","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13115","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13116","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13117","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13118","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13119","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13120","properties":[{"key":"ProteinId","value":"AAA59987.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"K03199","properties":[{"key":"ProteinId","value":"AAA59989.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M14694","properties":[{"key":"ProteinId","value":"AAA61211.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M14695","properties":[{"key":"ProteinId","value":"AAA61212.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M22898","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22882","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22883","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22884","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22887","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22888","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22894","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22895","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22896","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22897","properties":[{"key":"ProteinId","value":"AAA59988.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X01405","properties":[{"key":"ProteinId","value":"CAA25652.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60011","properties":[{"key":"ProteinId","value":"CAA42626.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60012","properties":[{"key":"ProteinId","value":"CAA42627.1"},{"key":"Status","value":"ALT_TERM"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60013","properties":[{"key":"ProteinId","value":"CAA42628.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60014","properties":[{"key":"ProteinId","value":"CAA42629.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60015","properties":[{"key":"ProteinId","value":"CAA42630.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60016","properties":[{"key":"ProteinId","value":"CAA42631.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60017","properties":[{"key":"ProteinId","value":"CAA42632.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60018","properties":[{"key":"ProteinId","value":"CAA42633.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60019","properties":[{"key":"ProteinId","value":"CAA42634.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X60020","properties":[{"key":"ProteinId","value":"CAA42635.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF307851","properties":[{"key":"ProteinId","value":"AAG28785.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ186648","properties":[{"key":"ProteinId","value":"ABA29753.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ186649","properties":[{"key":"ProteinId","value":"ABA29754.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ186650","properties":[{"key":"ProteinId","value":"ABA29755.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ186651","properties":[{"key":"ProteinId","value":"ABA29756.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ186652","properties":[{"key":"ProteinId","value":"ABA29757.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ191317","properties":[{"key":"ProteinId","value":"ABB80262.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ286964","properties":[{"key":"ProteinId","value":"ABB80266.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X54156","properties":[{"key":"ProteinId","value":"CAA38095.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U94788","properties":[{"key":"ProteinId","value":"AAC12971.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY838896","properties":[{"key":"ProteinId","value":"AAV80424.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF135121","properties":[{"key":"ProteinId","value":"AAD28535.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF135120","properties":[{"key":"ProteinId","value":"AAD28535.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF136271","properties":[{"key":"ProteinId","value":"AAD28628.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF136270","properties":[{"key":"ProteinId","value":"AAD28628.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB082923","properties":[{"key":"ProteinId","value":"BAC16799.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK312568","properties":[{"key":"ProteinId","value":"BAG35463.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC007421","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC087388","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471108","properties":[{"key":"ProteinId","value":"EAW90143.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471108","properties":[{"key":"ProteinId","value":"EAW90144.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC003596","properties":[{"key":"ProteinId","value":"AAH03596.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY429684","properties":[{"key":"ProteinId","value":"AAR10356.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY390341","properties":[{"key":"ProteinId","value":"AAQ90158.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY359814","properties":[{"key":"ProteinId","value":"AAR13239.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U63714","properties":[{"key":"ProteinId","value":"AAB39322.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209136","properties":[{"key":"ProteinId","value":"AAF36362.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209128","properties":[{"key":"ProteinId","value":"AAF36354.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209129","properties":[{"key":"ProteinId","value":"AAF36355.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209130","properties":[{"key":"ProteinId","value":"AAF36356.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209131","properties":[{"key":"ProteinId","value":"AAF36357.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209132","properties":[{"key":"ProteinId","value":"AAF36358.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209133","properties":[{"key":"ProteinId","value":"AAF36359.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209134","properties":[{"key":"ProteinId","value":"AAF36360.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209135","properties":[{"key":"ProteinId","value":"AAF36361.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209148","properties":[{"key":"ProteinId","value":"AAF36374.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209149","properties":[{"key":"ProteinId","value":"AAF36375.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209150","properties":[{"key":"ProteinId","value":"AAF36376.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209151","properties":[{"key":"ProteinId","value":"AAF36377.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209152","properties":[{"key":"ProteinId","value":"AAF36378.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209153","properties":[{"key":"ProteinId","value":"AAF36379.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209154","properties":[{"key":"ProteinId","value":"AAF36380.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209155","properties":[{"key":"ProteinId","value":"AAF36381.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF209156","properties":[{"key":"ProteinId","value":"AAF36382.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF210309","properties":[{"key":"ProteinId","value":"AAF63442.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF210308","properties":[{"key":"ProteinId","value":"AAF63442.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF210310","properties":[{"key":"ProteinId","value":"AAF63443.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF240684","properties":[{"key":"ProteinId","value":"AAK76358.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF240685","properties":[{"key":"ProteinId","value":"AAK76359.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY270155","properties":[{"key":"ProteinId","value":"AAP30003.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS11118.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-1"},{"database":"CCDS","id":"CCDS45605.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-3"},{"database":"CCDS","id":"CCDS45606.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-2"},{"database":"CCDS","id":"CCDS73966.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-7"},{"database":"CCDS","id":"CCDS73967.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-9"},{"database":"CCDS","id":"CCDS73968.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-8"},{"database":"CCDS","id":"CCDS73969.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-4"},{"database":"CCDS","id":"CCDS73970.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-6"},{"database":"CCDS","id":"CCDS73971.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-5"},{"database":"PIR","id":"A25224","properties":[{"key":"EntryName","value":"DNHU53"}]},{"database":"RefSeq","id":"NP_000537.3","properties":[{"key":"NucleotideSequenceId","value":"NM_000546.5"}],"isoformId":"P04637-1"},{"database":"RefSeq","id":"NP_001119584.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126112.3"}],"isoformId":"P04637-1"},{"database":"RefSeq","id":"NP_001119585.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126113.3"}],"isoformId":"P04637-3"},{"database":"RefSeq","id":"NP_001119586.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126114.3"}],"isoformId":"P04637-2"},{"database":"RefSeq","id":"NP_001119587.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126115.2"}],"isoformId":"P04637-7"},{"database":"RefSeq","id":"NP_001119588.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126116.2"}],"isoformId":"P04637-8"},{"database":"RefSeq","id":"NP_001119589.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126117.2"}],"isoformId":"P04637-9"},{"database":"RefSeq","id":"NP_001119590.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126118.2"}],"isoformId":"P04637-4"},{"database":"RefSeq","id":"NP_001263624.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001276695.3"}],"isoformId":"P04637-6"},{"database":"RefSeq","id":"NP_001263625.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001276696.3"}],"isoformId":"P04637-5"},{"database":"RefSeq","id":"NP_001263626.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001276697.1"}]},{"database":"RefSeq","id":"NP_001263627.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001276698.1"}]},{"database":"RefSeq","id":"NP_001263628.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001276699.1"}]},{"database":"RefSeq","id":"NP_001263689.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001276760.3"}],"isoformId":"P04637-4"},{"database":"RefSeq","id":"NP_001263690.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001276761.3"}],"isoformId":"P04637-4"},{"database":"RefSeq","id":"NP_001394191.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407262.1"}],"isoformId":"P04637-1"},{"database":"RefSeq","id":"NP_001394192.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407263.1"}],"isoformId":"P04637-4"},{"database":"RefSeq","id":"NP_001394193.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407264.1"}],"isoformId":"P04637-1"},{"database":"RefSeq","id":"NP_001394194.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407265.1"}],"isoformId":"P04637-4"},{"database":"RefSeq","id":"NP_001394195.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407266.1"}],"isoformId":"P04637-1"},{"database":"RefSeq","id":"NP_001394196.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407267.1"}],"isoformId":"P04637-4"},{"database":"RefSeq","id":"NP_001394197.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407268.1"}],"isoformId":"P04637-2"},{"database":"RefSeq","id":"NP_001394198.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407269.1"}],"isoformId":"P04637-5"},{"database":"RefSeq","id":"NP_001394199.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407270.1"}],"isoformId":"P04637-2"},{"database":"RefSeq","id":"NP_001394200.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407271.1"}],"isoformId":"P04637-5"},{"database":"PDB","id":"1A1U","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/C=324-358"}]},{"database":"PDB","id":"1AIE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=326-356"}]},{"database":"PDB","id":"1C26","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=325-356"}]},{"database":"PDB","id":"1DT7","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"X/Y=367-388"}]},{"database":"PDB","id":"1GZH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/C=95-292"}]},{"database":"PDB","id":"1H26","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.24 A"},{"key":"Chains","value":"E=376-386"}]},{"database":"PDB","id":"1HS5","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=324-357"}]},{"database":"PDB","id":"1JSP","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=367-386"}]},{"database":"PDB","id":"1KZY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=95-289"}]},{"database":"PDB","id":"1MA3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B=372-389"}]},{"database":"PDB","id":"1OLG","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=319-360"}]},{"database":"PDB","id":"1OLH","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=319-360"}]},{"database":"PDB","id":"1PES","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=325-355"}]},{"database":"PDB","id":"1PET","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=325-355"}]},{"database":"PDB","id":"1SAE","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=319-360"}]},{"database":"PDB","id":"1SAF","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=319-360"}]},{"database":"PDB","id":"1SAK","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=319-360"}]},{"database":"PDB","id":"1SAL","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=319-360"}]},{"database":"PDB","id":"1TSR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C=94-312"}]},{"database":"PDB","id":"1TUP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C=94-312"}]},{"database":"PDB","id":"1UOL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"1XQH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"B/F=369-377"}]},{"database":"PDB","id":"1YC5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"B=372-389"}]},{"database":"PDB","id":"1YCQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B=13-29"}]},{"database":"PDB","id":"1YCR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B=15-29"}]},{"database":"PDB","id":"1YCS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=94-292"}]},{"database":"PDB","id":"2AC0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"2ADY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"2AHI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"2ATA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"2B3G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"B=33-60"}]},{"database":"PDB","id":"2BIM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.98 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2BIN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"2BIO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"2BIP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"2BIQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"2F1X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B=359-368"}]},{"database":"PDB","id":"2FEJ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=94-297"}]},{"database":"PDB","id":"2FOJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"B=361-367"}]},{"database":"PDB","id":"2FOO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B=358-363"}]},{"database":"PDB","id":"2GS0","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=20-73"}]},{"database":"PDB","id":"2H1L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.16 A"},{"key":"Chains","value":"M/N/O/P/Q/R/S/T/U/V/W/X=92-292"}]},{"database":"PDB","id":"2H2D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"B=372-389"}]},{"database":"PDB","id":"2H2F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B=372-389"}]},{"database":"PDB","id":"2H4F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"D=372-389"}]},{"database":"PDB","id":"2H4H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"B=372-389"}]},{"database":"PDB","id":"2H4J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"D=372-389"}]},{"database":"PDB","id":"2H59","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"D/E=372-389"}]},{"database":"PDB","id":"2J0Z","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=326-356"}]},{"database":"PDB","id":"2J10","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=326-356"}]},{"database":"PDB","id":"2J11","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=326-356"}]},{"database":"PDB","id":"2J1W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2J1X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2J1Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"2J1Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2J20","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2J21","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2K8F","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=1-39"}]},{"database":"PDB","id":"2L14","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=13-61"}]},{"database":"PDB","id":"2LY4","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=1-93"}]},{"database":"PDB","id":"2MEJ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=96-312"}]},{"database":"PDB","id":"2MWO","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=363-377"}]},{"database":"PDB","id":"2MWP","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=376-387"}]},{"database":"PDB","id":"2MWY","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=15-29"}]},{"database":"PDB","id":"2MZD","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=35-59"}]},{"database":"PDB","id":"2OCJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B/C/D=94-312"}]},{"database":"PDB","id":"2PCX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.54 A"},{"key":"Chains","value":"A=94-292"}]},{"database":"PDB","id":"2RUK","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=41-62"}]},{"database":"PDB","id":"2VUK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2WGX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2X0U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2X0V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2X0W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"2XWR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.68 A"},{"key":"Chains","value":"A/B=89-293"}]},{"database":"PDB","id":"2YBG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"2YDR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"P=144-154"}]},{"database":"PDB","id":"2Z5S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"P/Q/R=15-29"}]},{"database":"PDB","id":"2Z5T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"P/Q/R=15-29"}]},{"database":"PDB","id":"3D05","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"3D06","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.20 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"3D07","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"3D08","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"3D09","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"3D0A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"3DAB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"B/D/F/H=15-29"}]},{"database":"PDB","id":"3DAC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"B/P=17-37"}]},{"database":"PDB","id":"3IGK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"3IGL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"3KMD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/B/C/D=92-291"}]},{"database":"PDB","id":"3KZ8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.91 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"3LW1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.28 A"},{"key":"Chains","value":"P=385-393"}]},{"database":"PDB","id":"3OQ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"D/E=377-386"}]},{"database":"PDB","id":"3PDH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"D=372-389"}]},{"database":"PDB","id":"3Q01","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=94-356"}]},{"database":"PDB","id":"3Q05","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D=94-356"}]},{"database":"PDB","id":"3Q06","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B/C/D=96-354"}]},{"database":"PDB","id":"3SAK","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B/C/D=319-360"}]},{"database":"PDB","id":"3TG5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B=365-375"}]},{"database":"PDB","id":"3TS8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B/C/D=94-356"}]},{"database":"PDB","id":"3ZME","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"4AGL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"4AGM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"4AGN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"4AGO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"4AGP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"4AGQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.42 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"4BUZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"P=379-386"}]},{"database":"PDB","id":"4BV2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"E/H=376-388"}]},{"database":"PDB","id":"4HFZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.69 A"},{"key":"Chains","value":"B/D=15-29"}]},{"database":"PDB","id":"4HJE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.91 A"},{"key":"Chains","value":"A/B/C/D=92-291"}]},{"database":"PDB","id":"4IBQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"4IBS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.78 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"4IBT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"4IBU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"4IBV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"4IBW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"4IBY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"4IBZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.92 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"4IJT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.78 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"4KVP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B/C/D=94-312"}]},{"database":"PDB","id":"4LO9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D=94-312"}]},{"database":"PDB","id":"4LOE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B/C/D=94-312"}]},{"database":"PDB","id":"4LOF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"4MZI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.25 A"},{"key":"Chains","value":"A=94-292"}]},{"database":"PDB","id":"4MZR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B/C/D=94-358"}]},{"database":"PDB","id":"4QO1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.92 A"},{"key":"Chains","value":"B=92-312"}]},{"database":"PDB","id":"4RP6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"Z=252-258"}]},{"database":"PDB","id":"4RP7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"Z=253-258"}]},{"database":"PDB","id":"4X34","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"C/D=377-386"}]},{"database":"PDB","id":"4XR8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"C/D=94-292"}]},{"database":"PDB","id":"4ZZJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.74 A"},{"key":"Chains","value":"B=379-383"}]},{"database":"PDB","id":"5A7B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5AB9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.36 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5ABA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.62 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5AOI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.78 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5AOJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.47 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5AOK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5AOL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5AOM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5BUA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.81 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"5ECG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B=95-312"}]},{"database":"PDB","id":"5G4M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5G4N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5G4O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.48 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5HOU","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-61"}]},{"database":"PDB","id":"5HP0","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=37-61"}]},{"database":"PDB","id":"5HPD","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-61"}]},{"database":"PDB","id":"5LAP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.42 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5LGY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.92 A"},{"key":"Chains","value":"A/B/C/D=94-291"}]},{"database":"PDB","id":"5MCT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"5MCU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"5MCV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"5MCW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"5MF7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"5MG7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"5MHC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.20 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"5MOC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"5O1A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5O1B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.43 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5O1C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.32 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5O1D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.36 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5O1E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5O1F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5O1G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5O1H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.32 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5O1I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"5OL0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"C/D=372-389"}]},{"database":"PDB","id":"5UN8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.13 A"},{"key":"Chains","value":"E/F/G/H=144-154"}]},{"database":"PDB","id":"5XZC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"10.70 A"},{"key":"Chains","value":"B/C/D/E=92-356"}]},{"database":"PDB","id":"6FF9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D=97-289"}]},{"database":"PDB","id":"6FJ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"6GGA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6GGB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.32 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6GGC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.24 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6GGD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6GGE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.25 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6GGF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.32 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6LHD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=96-292"}]},{"database":"PDB","id":"6R5L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RJZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RK8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RKI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RKK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RKM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RL3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RL4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RL6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RM5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RM7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RWH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.68 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RWI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RWS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RWU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.46 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RX2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6RZ3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.23 A"},{"key":"Chains","value":"A=62-292"}]},{"database":"PDB","id":"6S39","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6S3C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6S40","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6S9Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6SHZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.24 A"},{"key":"Chains","value":"A/B=94-311"}]},{"database":"PDB","id":"6SI0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6SI1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6SI2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6SI3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6SI4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"6SIN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.64 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6SIO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6SIP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6SIQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6SL6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A=89-311"}]},{"database":"PDB","id":"6SLV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"P=382-393"}]},{"database":"PDB","id":"6T58","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B=17-56"}]},{"database":"PDB","id":"6V4F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"B=14-29"}]},{"database":"PDB","id":"6V4H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"B/D=14-29"}]},{"database":"PDB","id":"6VQO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"P/Q=168-176"}]},{"database":"PDB","id":"6VR1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.37 A"},{"key":"Chains","value":"P/Q=168-176"}]},{"database":"PDB","id":"6VR5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.38 A"},{"key":"Chains","value":"P/Q=168-176"}]},{"database":"PDB","id":"6VRM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.61 A"},{"key":"Chains","value":"P=168-176"}]},{"database":"PDB","id":"6VRN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.46 A"},{"key":"Chains","value":"P=168-176"}]},{"database":"PDB","id":"6W51","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.53 A"},{"key":"Chains","value":"C/F/I/L=168-176"}]},{"database":"PDB","id":"6XRE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.60 A"},{"key":"Chains","value":"M=1-393"}]},{"database":"PDB","id":"6ZNC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.64 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"7B46","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.02 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"7B47","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"7B48","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"7B49","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.42 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"7B4A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"7B4B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.76 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"7B4C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.71 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"7B4D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"7B4E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"7B4F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.78 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"7B4G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"7B4H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.39 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"7B4N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.32 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"7BWN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D/G/I/K/L/N/P=326-356"}]},{"database":"PDB","id":"7DHY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"7DHZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"A/B=94-293"}]},{"database":"PDB","id":"7DVD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.59 A"},{"key":"Chains","value":"A/B/C/D=92-290"}]},{"database":"PDB","id":"7EAX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A/B/C/D=96-289"}]},{"database":"PDB","id":"7EDS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.77 A"},{"key":"Chains","value":"A=94-293"}]},{"database":"PDB","id":"7EEU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=94-293"}]},{"database":"PDB","id":"7EL4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.11 A"},{"key":"Chains","value":"A=23-29"}]},{"database":"PDB","id":"7NMI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=17-56"}]},{"database":"PDB","id":"7RM4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.33 A"},{"key":"Chains","value":"C/H/M/R=168-176"}]},{"database":"PDB","id":"7V97","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.02 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"7XZX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.53 A"},{"key":"Chains","value":"K/L/M/N=94-293"}]},{"database":"PDB","id":"7XZZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.07 A"},{"key":"Chains","value":"K/L/M/N=1-393"}]},{"database":"PDB","id":"7YGI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=92-289"}]},{"database":"PDB","id":"8A31","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.46 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8A32","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.47 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8A92","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.37 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8CG7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8DC4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D=94-312"}]},{"database":"PDB","id":"8DC6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B/C/D=94-312"}]},{"database":"PDB","id":"8DC7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"8DC8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.72 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"8E7A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A=93-312"}]},{"database":"PDB","id":"8E7B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=93-312"}]},{"database":"PDB","id":"8GCR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.38 A"},{"key":"Chains","value":"B=94-312"}]},{"database":"PDB","id":"8HLL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.62 A"},{"key":"Chains","value":"A=95-290"}]},{"database":"PDB","id":"8HLM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.52 A"},{"key":"Chains","value":"A=95-290"}]},{"database":"PDB","id":"8HLN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A=95-290"}]},{"database":"PDB","id":"8J8N","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"9.02 A"},{"key":"Chains","value":"A/B/C/D=92-292"}]},{"database":"PDB","id":"8OXM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"E/F=11-22"}]},{"database":"PDB","id":"8OXO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"E/F=11-22"}]},{"database":"PDB","id":"8QWK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"8QWL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"8QWM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.54 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8QWN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A=94-312"}]},{"database":"PDB","id":"8QWO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8QWP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8R1F","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.67 A"},{"key":"Chains","value":"C=1-393"}]},{"database":"PDB","id":"8R1G","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.99 A"},{"key":"Chains","value":"C/F=1-393"}]},{"database":"PDB","id":"8RBA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8RBB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8RBC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.06 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8RCI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=94-294"}]},{"database":"PDB","id":"8UQR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.22 A"},{"key":"Chains","value":"A/B/C/D=326-356"}]},{"database":"PDB","id":"8WD2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"8XCB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.83 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"8XCE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D=94-293"}]},{"database":"PDB","id":"8XP5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A/B=95-292"}]},{"database":"PDB","id":"9BR3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"9BR4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"9C5S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.01 A"},{"key":"Chains","value":"A/B/C/D=17-30"}]},{"database":"PDB","id":"9CHT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.54 A"},{"key":"Chains","value":"B=1-312"}]},{"database":"PDB","id":"9FZB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A=94-294"}]},{"database":"PDB","id":"9G5H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"9G6T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.56 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"9G6U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.64 A"},{"key":"Chains","value":"A/B=94-312"}]},{"database":"PDB","id":"9R04","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.20 A"},{"key":"Chains","value":"K/L/M/N=1-393"}]},{"database":"PDB","id":"9R2M","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"K/L/M/N=1-393"}]},{"database":"PDB","id":"9R2P","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.18 A"},{"key":"Chains","value":"K/L/M/N=1-393"}]},{"database":"PDB","id":"9R2Q","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"K/L/M/N=1-393"}]},{"database":"PDBsum","id":"1A1U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1AIE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1C26","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1DT7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1GZH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H26","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1HS5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JSP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1KZY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1MA3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OLG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OLH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1PES","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1PET","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1SAE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1SAF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1SAK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1SAL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1TSR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1TUP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1UOL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1XQH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1YC5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1YCQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1YCR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1YCS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2AC0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2ADY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2AHI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2ATA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2B3G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2BIM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2BIN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2BIO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2BIP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2BIQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2F1X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2FEJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2FOJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2FOO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2GS0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2H1L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2H2D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2H2F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2H4F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2H4H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2H4J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2H59","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2J0Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2J10","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2J11","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2J1W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2J1X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2J1Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2J1Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2J20","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2J21","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2K8F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L14","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LY4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MEJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MWO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MWP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MWY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MZD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OCJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2PCX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2RUK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2VUK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WGX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2X0U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2X0V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2X0W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2XWR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2YBG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2YDR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2Z5S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2Z5T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3D05","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3D06","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3D07","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3D08","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3D09","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3D0A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3DAB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3DAC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3IGK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3IGL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3KMD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3KZ8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3LW1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3OQ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3PDH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3Q01","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3Q05","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3Q06","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3SAK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3TG5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3TS8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3ZME","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4AGL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4AGM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4AGN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4AGO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4AGP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4AGQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4BUZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4BV2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HFZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HJE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4IBQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4IBS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4IBT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4IBU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4IBV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4IBW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4IBY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4IBZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4IJT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4KVP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4LO9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4LOE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4LOF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4MZI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4MZR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4QO1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4RP6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4RP7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4X34","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4XR8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4ZZJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5A7B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5AB9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5ABA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5AOI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5AOJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5AOK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5AOL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5AOM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5BUA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5ECG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5G4M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5G4N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5G4O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5HOU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5HP0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5HPD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5LAP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5LGY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MCT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MCU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MCV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MCW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MF7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MG7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MHC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MOC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O1A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O1B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O1C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O1D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O1E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O1F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O1G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O1H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O1I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5OL0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UN8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5XZC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FF9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FJ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GGA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GGB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GGC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GGD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GGE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GGF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6LHD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6R5L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RJZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RK8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RKI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RKK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RKM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RL3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RL4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RL6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RM5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RM7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RWH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RWI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RWS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RWU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RX2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RZ3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6S39","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6S3C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6S40","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6S9Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SHZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SI0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SI1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SI2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SI3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SI4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SIN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SIO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SIP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SIQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SL6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SLV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6T58","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V4F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V4H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6VQO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6VR1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6VR5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6VRM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6VRN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6W51","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XRE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ZNC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B46","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B47","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B48","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B49","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B4A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B4B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B4C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B4D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B4E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B4F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B4G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B4H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B4N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7BWN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7DHY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7DHZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7DVD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EAX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EDS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EEU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EL4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NMI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RM4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7V97","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XZX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XZZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7YGI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8A31","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8A32","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8A92","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CG7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DC4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DC6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DC7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DC8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8E7A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8E7B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GCR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HLL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HLM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HLN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8J8N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OXM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OXO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QWK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QWL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QWM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QWN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QWO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QWP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8R1F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8R1G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RBA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RBB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RBC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RCI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UQR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WD2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XCB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XCE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XP5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BR3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BR4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9C5S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CHT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9FZB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9G5H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9G6T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9G6U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R04","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R2M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R2P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R2Q","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0378","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17265","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17266","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-18809","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-18810","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-22294","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-22827","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29941","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33533","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33535","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36075","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45601","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53478","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53532","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53536","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53537","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6791","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-8926","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-8927","properties":[{"key":"Description","value":"-"}]},{"database":"PCDDB","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"113010","properties":[{"key":"Interactions","value":"2579"}]},{"database":"ComplexPortal","id":"CPX-6093","properties":[{"key":"EntryName","value":"p53-MDM2-MDM4 transcriptional regulation complex"}]},{"database":"ComplexPortal","id":"CPX-663","properties":[{"key":"EntryName","value":"p53-MDM4 transcriptional regulation complex"}]},{"database":"ComplexPortal","id":"CPX-759","properties":[{"key":"EntryName","value":"p53-MDM2 transcriptional regulation complex"}]},{"database":"CORUM","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-368N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P04637","properties":[{"key":"Number of interactors","value":"3248"}]},{"database":"IntAct","id":"P04637","properties":[{"key":"Interactions","value":"847"}]},{"database":"MINT","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-TP53","properties":[{"key":"Evidences","value":"109 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000269305","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4096","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB08363","properties":[{"key":"GenericName","value":"1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine"}]},{"database":"DrugBank","id":"DB13010","properties":[{"key":"GenericName","value":"4-isothioureidobutyronitrile"}]},{"database":"DrugBank","id":"DB00945","properties":[{"key":"GenericName","value":"Acetylsalicylic acid"}]},{"database":"DrugBank","id":"DB17549","properties":[{"key":"GenericName","value":"Alrizomadlin"}]},{"database":"DrugBank","id":"DB05404","properties":[{"key":"GenericName","value":"AZD 3355"}]},{"database":"DrugBank","id":"DB15455","properties":[{"key":"GenericName","value":"Cenersen"}]},{"database":"DrugBank","id":"DB17507","properties":[{"key":"GenericName","value":"COTI-2"}]},{"database":"DrugBank","id":"DB11684","properties":[{"key":"GenericName","value":"Eprenetapopt"}]},{"database":"DrugBank","id":"DB17039","properties":[{"key":"GenericName","value":"Nutlin-3"}]},{"database":"DrugBank","id":"DB12541","properties":[{"key":"GenericName","value":"SAR-405838"}]},{"database":"DrugBank","id":"DB16331","properties":[{"key":"GenericName","value":"Siremadlin"}]},{"database":"DrugBank","id":"DB16447","properties":[{"key":"GenericName","value":"Thymoquinone"}]},{"database":"DrugBank","id":"DB03347","properties":[{"key":"GenericName","value":"Triethyl phosphate"}]},{"database":"DrugBank","id":"DB01593","properties":[{"key":"GenericName","value":"Zinc"}]},{"database":"DrugBank","id":"DB14487","properties":[{"key":"GenericName","value":"Zinc acetate"}]},{"database":"DrugBank","id":"DB14533","properties":[{"key":"GenericName","value":"Zinc chloride"}]},{"database":"DrugBank","id":"DB14548","properties":[{"key":"GenericName","value":"Zinc sulfate, unspecified form"}]},{"database":"MoonDB","id":"P04637","properties":[{"key":"Type","value":"Predicted"}]},{"database":"TCDB","id":"1.C.110.1.1","properties":[{"key":"FamilyName","value":"the pore-forming pnc-27 peptide of 32 aas from the p53 tumor suppressor protein (pnc-27) family"}]},{"database":"GlyCosmos","id":"P04637","properties":[{"key":"glycosylation","value":"1 site, 1 glycan"}]},{"database":"GlyGen","id":"P04637","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TP53","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"269849759","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5895","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5896","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-951","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000269305","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51728","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-1"},{"database":"ProteomicsDB","id":"51729","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-2"},{"database":"ProteomicsDB","id":"51730","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-3"},{"database":"ProteomicsDB","id":"51731","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-4"},{"database":"ProteomicsDB","id":"51732","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-5"},{"database":"ProteomicsDB","id":"51733","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-6"},{"database":"ProteomicsDB","id":"51734","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-7"},{"database":"ProteomicsDB","id":"51735","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-8"},{"database":"ProteomicsDB","id":"51736","properties":[{"key":"Description","value":"-"}],"isoformId":"P04637-9"},{"database":"Pumba","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P04637","properties":[{"key":"antibodies","value":"67 sequenced antibodies"}]},{"database":"Antibodypedia","id":"3525","properties":[{"key":"antibodies","value":"9670 antibodies from 67 providers"}]},{"database":"CPTC","id":"P04637","properties":[{"key":"antibodies","value":"2 antibodies"}]},{"database":"DNASU","id":"7157","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000269305.9","properties":[{"key":"ProteinId","value":"ENSP00000269305.4"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000420246.6","properties":[{"key":"ProteinId","value":"ENSP00000391127.2"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-2"},{"database":"Ensembl","id":"ENST00000445888.6","properties":[{"key":"ProteinId","value":"ENSP00000391478.2"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000455263.6","properties":[{"key":"ProteinId","value":"ENSP00000398846.2"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-3"},{"database":"Ensembl","id":"ENST00000503591.2","properties":[{"key":"ProteinId","value":"ENSP00000426252.2"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000504290.5","properties":[{"key":"ProteinId","value":"ENSP00000484409.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-9"},{"database":"Ensembl","id":"ENST00000504937.5","properties":[{"key":"ProteinId","value":"ENSP00000481179.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-7"},{"database":"Ensembl","id":"ENST00000508793.6","properties":[{"key":"ProteinId","value":"ENSP00000424104.2"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000509690.6","properties":[{"key":"ProteinId","value":"ENSP00000425104.2"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-7"},{"database":"Ensembl","id":"ENST00000510385.5","properties":[{"key":"ProteinId","value":"ENSP00000478499.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-8"},{"database":"Ensembl","id":"ENST00000610292.4","properties":[{"key":"ProteinId","value":"ENSP00000478219.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-4"},{"database":"Ensembl","id":"ENST00000610538.4","properties":[{"key":"ProteinId","value":"ENSP00000480868.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-6"},{"database":"Ensembl","id":"ENST00000619485.4","properties":[{"key":"ProteinId","value":"ENSP00000482537.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-4"},{"database":"Ensembl","id":"ENST00000620739.4","properties":[{"key":"ProteinId","value":"ENSP00000481638.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-4"},{"database":"Ensembl","id":"ENST00000622645.4","properties":[{"key":"ProteinId","value":"ENSP00000482222.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-5"},{"database":"Ensembl","id":"ENST00000714357.1","properties":[{"key":"ProteinId","value":"ENSP00000519624.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000714359.1","properties":[{"key":"ProteinId","value":"ENSP00000519626.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000905353.1","properties":[{"key":"ProteinId","value":"ENSP00000575412.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000923566.1","properties":[{"key":"ProteinId","value":"ENSP00000593625.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000923567.1","properties":[{"key":"ProteinId","value":"ENSP00000593626.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000923568.1","properties":[{"key":"ProteinId","value":"ENSP00000593627.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"Ensembl","id":"ENST00000923569.1","properties":[{"key":"ProteinId","value":"ENSP00000593628.1"},{"key":"GeneId","value":"ENSG00000141510.20"}],"isoformId":"P04637-1"},{"database":"GeneID","id":"7157","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:7157","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000269305.9","properties":[{"key":"ProteinId","value":"ENSP00000269305.4"},{"key":"RefSeqNucleotideId","value":"NM_000546.6"},{"key":"RefSeqProteinId","value":"NP_000537.3"}]},{"database":"UCSC","id":"uc002gij.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P04637-1"},{"database":"AGR","id":"HGNC:11998","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"7157","properties":[{"key":"Number of evidences","value":"392 evidence items across 285 molecular profiles"}]},{"database":"ClinPGx","id":"PA36679","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7157","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"7157","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TP53","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"TP53","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11998","properties":[{"key":"GeneName","value":"TP53"}]},{"database":"HPA","id":"ENSG00000141510","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"TP53","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"133239","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"151623","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"191170","properties":[{"key":"Type","value":"gene+phenotype"}]},{"database":"MIM","id":"202300","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"211980","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"260500","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"275355","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"614740","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"618165","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000141510","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"1501","properties":[{"key":"Disease","value":"Adrenocortical carcinoma"}]},{"database":"Orphanet","id":"210159","properties":[{"key":"Disease","value":"Adult hepatocellular carcinoma"}]},{"database":"Orphanet","id":"99756","properties":[{"key":"Disease","value":"Alveolar rhabdomyosarcoma"}]},{"database":"Orphanet","id":"67038","properties":[{"key":"Disease","value":"B-cell chronic lymphocytic leukemia"}]},{"database":"Orphanet","id":"585909","properties":[{"key":"Disease","value":"B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)"}]},{"database":"Orphanet","id":"667662","properties":[{"key":"Disease","value":"Breast implant-associated anaplastic large cell lymphoma"}]},{"database":"Orphanet","id":"251899","properties":[{"key":"Disease","value":"Choroid plexus carcinoma"}]},{"database":"Orphanet","id":"96253","properties":[{"key":"Disease","value":"Cushing disease"}]},{"database":"Orphanet","id":"99757","properties":[{"key":"Disease","value":"Embryonal rhabdomyosarcoma"}]},{"database":"Orphanet","id":"3318","properties":[{"key":"Disease","value":"Essential thrombocythemia"}]},{"database":"Orphanet","id":"1333","properties":[{"key":"Disease","value":"Familial pancreatic carcinoma"}]},{"database":"Orphanet","id":"251579","properties":[{"key":"Disease","value":"Giant cell glioblastoma"}]},{"database":"Orphanet","id":"251576","properties":[{"key":"Disease","value":"Gliosarcoma"}]},{"database":"Orphanet","id":"145","properties":[{"key":"Disease","value":"Hereditary breast and/or ovarian cancer syndrome"}]},{"database":"Orphanet","id":"524","properties":[{"key":"Disease","value":"Li-Fraumeni syndrome"}]},{"database":"Orphanet","id":"52688","properties":[{"key":"Disease","value":"Myelodysplastic syndrome"}]},{"database":"Orphanet","id":"668","properties":[{"key":"Disease","value":"Osteosarcoma"}]},{"database":"Orphanet","id":"2807","properties":[{"key":"Disease","value":"Papilloma of choroid plexus"}]},{"database":"Orphanet","id":"293199","properties":[{"key":"Disease","value":"Pleomorphic rhabdomyosarcoma"}]},{"database":"Orphanet","id":"70573","properties":[{"key":"Disease","value":"Small cell lung cancer"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000141510","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QVY3","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183153","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HKKGEPC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5915660at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P04637","properties":[{"key":"Number of GO annotations","value":"8 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-111448","properties":[{"key":"PathwayName","value":"Activation of NOXA and translocation to mitochondria"}]},{"database":"Reactome","id":"R-HSA-139915","properties":[{"key":"PathwayName","value":"Activation of PUMA and translocation to mitochondria"}]},{"database":"Reactome","id":"R-HSA-1912408","properties":[{"key":"PathwayName","value":"Pre-NOTCH Transcription and Translation"}]},{"database":"Reactome","id":"R-HSA-2559580","properties":[{"key":"PathwayName","value":"Oxidative Stress Induced Senescence"}]},{"database":"Reactome","id":"R-HSA-2559584","properties":[{"key":"PathwayName","value":"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"}]},{"database":"Reactome","id":"R-HSA-2559585","properties":[{"key":"PathwayName","value":"Oncogene Induced Senescence"}]},{"database":"Reactome","id":"R-HSA-2559586","properties":[{"key":"PathwayName","value":"DNA Damage/Telomere Stress Induced Senescence"}]},{"database":"Reactome","id":"R-HSA-3232118","properties":[{"key":"PathwayName","value":"SUMOylation of transcription factors"}]},{"database":"Reactome","id":"R-HSA-349425","properties":[{"key":"PathwayName","value":"Autodegradation of the E3 ubiquitin ligase COP1"}]},{"database":"Reactome","id":"R-HSA-390471","properties":[{"key":"PathwayName","value":"Association of TriC/CCT with target proteins during biosynthesis"}]},{"database":"Reactome","id":"R-HSA-5620971","properties":[{"key":"PathwayName","value":"Pyroptosis"}]},{"database":"Reactome","id":"R-HSA-5628897","properties":[{"key":"PathwayName","value":"TP53 Regulates Metabolic Genes"}]},{"database":"Reactome","id":"R-HSA-5689880","properties":[{"key":"PathwayName","value":"Ub-specific processing proteases"}]},{"database":"Reactome","id":"R-HSA-5689896","properties":[{"key":"PathwayName","value":"Ovarian tumor domain proteases"}]},{"database":"Reactome","id":"R-HSA-5693565","properties":[{"key":"PathwayName","value":"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"}]},{"database":"Reactome","id":"R-HSA-6785807","properties":[{"key":"PathwayName","value":"Interleukin-4 and Interleukin-13 signaling"}]},{"database":"Reactome","id":"R-HSA-6796648","properties":[{"key":"PathwayName","value":"TP53 Regulates Transcription of DNA Repair Genes"}]},{"database":"Reactome","id":"R-HSA-6803204","properties":[{"key":"PathwayName","value":"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"}]},{"database":"Reactome","id":"R-HSA-6803205","properties":[{"key":"PathwayName","value":"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"}]},{"database":"Reactome","id":"R-HSA-6803207","properties":[{"key":"PathwayName","value":"TP53 Regulates Transcription of Caspase Activators and Caspases"}]},{"database":"Reactome","id":"R-HSA-6803211","properties":[{"key":"PathwayName","value":"TP53 Regulates Transcription of Death Receptors and Ligands"}]},{"database":"Reactome","id":"R-HSA-6804114","properties":[{"key":"PathwayName","value":"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"}]},{"database":"Reactome","id":"R-HSA-6804115","properties":[{"key":"PathwayName","value":"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"}]},{"database":"Reactome","id":"R-HSA-6804116","properties":[{"key":"PathwayName","value":"TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"}]},{"database":"Reactome","id":"R-HSA-6804754","properties":[{"key":"PathwayName","value":"Regulation of TP53 Expression"}]},{"database":"Reactome","id":"R-HSA-6804756","properties":[{"key":"PathwayName","value":"Regulation of TP53 Activity through Phosphorylation"}]},{"database":"Reactome","id":"R-HSA-6804757","properties":[{"key":"PathwayName","value":"Regulation of TP53 Degradation"}]},{"database":"Reactome","id":"R-HSA-6804758","properties":[{"key":"PathwayName","value":"Regulation of TP53 Activity through Acetylation"}]},{"database":"Reactome","id":"R-HSA-6804759","properties":[{"key":"PathwayName","value":"Regulation of TP53 Activity through Association with Co-factors"}]},{"database":"Reactome","id":"R-HSA-6804760","properties":[{"key":"PathwayName","value":"Regulation of TP53 Activity through Methylation"}]},{"database":"Reactome","id":"R-HSA-6811555","properties":[{"key":"PathwayName","value":"PI5P Regulates TP53 Acetylation"}]},{"database":"Reactome","id":"R-HSA-69473","properties":[{"key":"PathwayName","value":"G2/M DNA damage checkpoint"}]},{"database":"Reactome","id":"R-HSA-69481","properties":[{"key":"PathwayName","value":"G2/M Checkpoints"}]},{"database":"Reactome","id":"R-HSA-69541","properties":[{"key":"PathwayName","value":"Stabilization of p53"}]},{"database":"Reactome","id":"R-HSA-69895","properties":[{"key":"PathwayName","value":"Transcriptional activation of cell cycle inhibitor p21"}]},{"database":"Reactome","id":"R-HSA-70635","properties":[{"key":"PathwayName","value":"Urea cycle"}]},{"database":"Reactome","id":"R-HSA-8852276","properties":[{"key":"PathwayName","value":"The role of GTSE1 in G2/M progression after G2 checkpoint"}]},{"database":"Reactome","id":"R-HSA-8853884","properties":[{"key":"PathwayName","value":"Transcriptional Regulation by VENTX"}]},{"database":"Reactome","id":"R-HSA-8941855","properties":[{"key":"PathwayName","value":"RUNX3 regulates CDKN1A transcription"}]},{"database":"Reactome","id":"R-HSA-8943724","properties":[{"key":"PathwayName","value":"Regulation of PTEN gene transcription"}]},{"database":"Reactome","id":"R-HSA-9723905","properties":[{"key":"PathwayName","value":"Loss of function of TP53 in cancer due to loss of tetramerization ability"}]},{"database":"Reactome","id":"R-HSA-9725370","properties":[{"key":"PathwayName","value":"Signaling by ALK fusions and activated point mutants"}]},{"database":"Reactome","id":"R-HSA-9758274","properties":[{"key":"PathwayName","value":"Regulation of NF-kappa B signaling"}]},{"database":"Reactome","id":"R-HSA-9819196","properties":[{"key":"PathwayName","value":"Zygotic genome activation (ZGA)"}]},{"database":"Reactome","id":"R-HSA-983231","properties":[{"key":"PathwayName","value":"Factors involved in megakaryocyte development and platelet production"}]},{"database":"Reactome","id":"R-HSA-9833482","properties":[{"key":"PathwayName","value":"PKR-mediated signaling"}]},{"database":"SABIO-RK","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000141510","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"7157","properties":[{"key":"hits","value":"66 hits in 1218 CRISPR screens"}]},{"database":"CD-CODE","id":"1A18FFC4","properties":[{"key":"EntryName","value":"Paraspeckle"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"A1A97FAB","properties":[{"key":"EntryName","value":"Synthetic Condensate 000191"}]},{"database":"CD-CODE","id":"B5B9A610","properties":[{"key":"EntryName","value":"PML body"}]},{"database":"CD-CODE","id":"E11B6BAB","properties":[{"key":"EntryName","value":"Synthetic Condensate 000195"}]},{"database":"ChiTaRS","id":"TP53","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P04637","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"P53","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"7157","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P04637","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P04637","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"P04637","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000141510","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 144 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P04637","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28842590"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15710329"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17805299"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22521434"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23629966"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16131611"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20096447"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20810912"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21597459"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24625977"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26634371"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7720704"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14963330"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12667443"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25168243"}]},{"database":"GO","id":"GO:0016363","properties":[{"key":"GoTerm","value":"C:nuclear matrix"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11080164"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12080348"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11080164"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12915590"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14963330"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16322561"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16507995"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17403783"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19011621"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19234109"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20096447"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20810912"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21597459"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24625977"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26634371"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36108750"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7720704"}]},{"database":"GO","id":"GO:0016605","properties":[{"key":"GoTerm","value":"C:PML body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22869143"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17310983"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9529249"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"17145718"}]},{"database":"GO","id":"GO:0071889","properties":[{"key":"GoTerm","value":"F:14-3-3 protein binding"},{"key":"GoEvidenceType","value":"EXP:DisProt"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20206173"}]},{"database":"GO","id":"GO:0036310","properties":[{"key":"GoTerm","value":"F:ATP-dependent DNA/DNA annealing activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8183576"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16322561"}]},{"database":"GO","id":"GO:0000987","properties":[{"key":"GoTerm","value":"F:cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10329733"}]},{"database":"GO","id":"GO:0005507","properties":[{"key":"GoTerm","value":"F:copper ion binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7824276"}]},{"database":"GO","id":"GO:0001046","properties":[{"key":"GoTerm","value":"F:core promoter sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23629966"}]},{"database":"GO","id":"GO:0097718","properties":[{"key":"GoTerm","value":"F:disordered domain specific binding"},{"key":"GoEvidenceType","value":"IPI:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15629713"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15358771"}]},{"database":"GO","id":"GO:0001228","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12609999"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17145718"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17146433"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22578566"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7587074"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24652652"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35618207"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36634798"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38653238"}]},{"database":"GO","id":"GO:0001227","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription repressor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10329733"}]},{"database":"GO","id":"GO:0019899","properties":[{"key":"GoTerm","value":"F:enzyme binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17805299"}]},{"database":"GO","id":"GO:0140296","properties":[{"key":"GoTerm","value":"F:general transcription initiation factor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15053879"}]},{"database":"GO","id":"GO:0042826","properties":[{"key":"GoTerm","value":"F:histone deacetylase binding"},{"key":"GoEvidenceType","value":"IPI:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23629966"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19011621"}]},{"database":"GO","id":"GO:0097371","properties":[{"key":"GoTerm","value":"F:MDM2/MDM4 family protein binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0140693","properties":[{"key":"GoTerm","value":"F:molecular condensate scaffold activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31953488"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35618207"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36108750"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36634798"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38653238"}]},{"database":"GO","id":"GO:0140677","properties":[{"key":"GoTerm","value":"F:molecular function activator activity"},{"key":"GoEvidenceType","value":"IPI:DisProt"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7559631"}]},{"database":"GO","id":"GO:0003730","properties":[{"key":"GoTerm","value":"F:mRNA 3'-UTR binding"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16213212"}]},{"database":"GO","id":"GO:0002039","properties":[{"key":"GoTerm","value":"F:p53 binding"},{"key":"GoEvidenceType","value":"IPI:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25417702"}]},{"database":"GO","id":"GO:1990841","properties":[{"key":"GoTerm","value":"F:promoter-specific chromatin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20725088"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24356969"}]},{"database":"GO","id":"GO:0002020","properties":[{"key":"GoTerm","value":"F:protease binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11923872"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10837489"}]},{"database":"GO","id":"GO:0051721","properties":[{"key":"GoTerm","value":"F:protein phosphatase 2A binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17245430"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15358771"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"18086682"}]},{"database":"GO","id":"GO:0030971","properties":[{"key":"GoTerm","value":"F:receptor tyrosine kinase binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23027130"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22578566"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0061629","properties":[{"key":"GoTerm","value":"F:RNA polymerase II-specific DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19505873"}]},{"database":"GO","id":"GO:0001094","properties":[{"key":"GoTerm","value":"F:TFIID-class transcription factor complex binding"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15710329"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17996705"}]},{"database":"GO","id":"GO:0001223","properties":[{"key":"GoTerm","value":"F:transcription coactivator binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11950834"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"8875929"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10065153"}]},{"database":"GO","id":"GO:0006914","properties":[{"key":"GoTerm","value":"P:autophagy"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23629966"}]},{"database":"GO","id":"GO:0048539","properties":[{"key":"GoTerm","value":"P:bone marrow development"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30146126"}]},{"database":"GO","id":"GO:0072717","properties":[{"key":"GoTerm","value":"P:cellular response to actinomycin D"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15314173"}]},{"database":"GO","id":"GO:0071480","properties":[{"key":"GoTerm","value":"P:cellular response to gamma radiation"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16213212"}]},{"database":"GO","id":"GO:0042149","properties":[{"key":"GoTerm","value":"P:cellular response to glucose starvation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21471221"}]},{"database":"GO","id":"GO:0071456","properties":[{"key":"GoTerm","value":"P:cellular response to hypoxia"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"20810912"}]},{"database":"GO","id":"GO:0071479","properties":[{"key":"GoTerm","value":"P:cellular response to ionizing radiation"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20160708"}]},{"database":"GO","id":"GO:0034644","properties":[{"key":"GoTerm","value":"P:cellular response to UV"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16213212"}]},{"database":"GO","id":"GO:0071466","properties":[{"key":"GoTerm","value":"P:cellular response to xenobiotic stimulus"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"20810912"}]},{"database":"GO","id":"GO:0090398","properties":[{"key":"GoTerm","value":"P:cellular senescence"},{"key":"GoEvidenceType","value":"IMP:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12080348"}]},{"database":"GO","id":"GO:0048512","properties":[{"key":"GoTerm","value":"P:circadian behavior"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008340","properties":[{"key":"GoTerm","value":"P:determination of adult lifespan"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0006974","properties":[{"key":"GoTerm","value":"P:DNA damage response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17938203"}]},{"database":"GO","id":"GO:0030330","properties":[{"key":"GoTerm","value":"P:DNA damage response, signal transduction by p53 class mediator"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15149599"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16213212"}]},{"database":"GO","id":"GO:0043153","properties":[{"key":"GoTerm","value":"P:entrainment of circadian clock by photoperiod"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006983","properties":[{"key":"GoTerm","value":"P:ER overload response"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14744935"}]},{"database":"GO","id":"GO:0002244","properties":[{"key":"GoTerm","value":"P:hematopoietic progenitor cell differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30146126"}]},{"database":"GO","id":"GO:0060218","properties":[{"key":"GoTerm","value":"P:hematopoietic stem cell differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30146126"}]},{"database":"GO","id":"GO:0008104","properties":[{"key":"GoTerm","value":"P:intracellular protein localization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16507995"}]},{"database":"GO","id":"GO:0097193","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"TAS:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16462759"}]},{"database":"GO","id":"GO:0072332","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway by p53 class mediator"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16322561"}]},{"database":"GO","id":"GO:0042771","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17403783"}]},{"database":"GO","id":"GO:0070059","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031571","properties":[{"key":"GoTerm","value":"P:mitotic G1 DNA damage checkpoint signaling"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7958916"}]},{"database":"GO","id":"GO:0009299","properties":[{"key":"GoTerm","value":"P:mRNA transcription"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16479015"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20124405"}]},{"database":"GO","id":"GO:0030308","properties":[{"key":"GoTerm","value":"P:negative regulation of cell growth"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8986812"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22783376"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24051492"}]},{"database":"GO","id":"GO:0048147","properties":[{"key":"GoTerm","value":"P:negative regulation of fibroblast proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10962037"}]},{"database":"GO","id":"GO:1903451","properties":[{"key":"GoTerm","value":"P:negative regulation of G1 to G0 transition"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15314173"}]},{"database":"GO","id":"GO:0051097","properties":[{"key":"GoTerm","value":"P:negative regulation of helicase activity"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7663514"}]},{"database":"GO","id":"GO:1905856","properties":[{"key":"GoTerm","value":"P:negative regulation of pentose-phosphate shunt"},{"key":"GoEvidenceType","value":"IMP:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21336310"}]},{"database":"GO","id":"GO:0032211","properties":[{"key":"GoTerm","value":"P:negative regulation of telomere maintenance via telomerase"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10597287"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10329733"}]},{"database":"GO","id":"GO:0006289","properties":[{"key":"GoTerm","value":"P:nucleotide-excision repair"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7663514"}]},{"database":"GO","id":"GO:0097252","properties":[{"key":"GoTerm","value":"P:oligodendrocyte apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7720704"}]},{"database":"GO","id":"GO:0090403","properties":[{"key":"GoTerm","value":"P:oxidative stress-induced premature senescence"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19951988"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12667443"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15565177"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20959462"}]},{"database":"GO","id":"GO:2000774","properties":[{"key":"GoTerm","value":"P:positive regulation of cellular senescence"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29474172"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16322561"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17403783"}]},{"database":"GO","id":"GO:1900119","properties":[{"key":"GoTerm","value":"P:positive regulation of execution phase of apoptosis"},{"key":"GoEvidenceType","value":"IMP:AgBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14985081"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15314173"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20332243"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26100857"}]},{"database":"GO","id":"GO:2001244","properties":[{"key":"GoTerm","value":"P:positive regulation of intrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14963330"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27031958"}]},{"database":"GO","id":"GO:1902895","properties":[{"key":"GoTerm","value":"P:positive regulation of miRNA transcription"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20546595"}]},{"database":"GO","id":"GO:0062100","properties":[{"key":"GoTerm","value":"P:positive regulation of programmed necrotic cell death"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:2000379","properties":[{"key":"GoTerm","value":"P:positive regulation of reactive oxygen species metabolic process"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20160708"}]},{"database":"GO","id":"GO:0090200","properties":[{"key":"GoTerm","value":"P:positive regulation of release of cytochrome c from mitochondria"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14963330"}]},{"database":"GO","id":"GO:0045899","properties":[{"key":"GoTerm","value":"P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0070245","properties":[{"key":"GoTerm","value":"P:positive regulation of thymocyte apoptotic process"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20959462"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24652652"}]},{"database":"GO","id":"GO:0051262","properties":[{"key":"GoTerm","value":"P:protein tetramerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0065003","properties":[{"key":"GoTerm","value":"P:protein-containing complex assembly"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12915590"}]},{"database":"GO","id":"GO:0007265","properties":[{"key":"GoTerm","value":"P:Ras protein signal transduction"},{"key":"GoEvidenceType","value":"IEP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"9054499"}]},{"database":"GO","id":"GO:0042981","properties":[{"key":"GoTerm","value":"P:regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14744935"}]},{"database":"GO","id":"GO:0051726","properties":[{"key":"GoTerm","value":"P:regulation of cell cycle"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15149599"}]},{"database":"GO","id":"GO:1902749","properties":[{"key":"GoTerm","value":"P:regulation of cell cycle G2/M phase transition"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10962037"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7587074"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30089260"}]},{"database":"GO","id":"GO:0090399","properties":[{"key":"GoTerm","value":"P:replicative senescence"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19951988"}]},{"database":"GO","id":"GO:0046677","properties":[{"key":"GoTerm","value":"P:response to antibiotic"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"20810912"}]},{"database":"GO","id":"GO:0010332","properties":[{"key":"GoTerm","value":"P:response to gamma radiation"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7958916"}]},{"database":"GO","id":"GO:0072331","properties":[{"key":"GoTerm","value":"P:signal transduction by p53 class mediator"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15314173"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18549481"}]},{"database":"GO","id":"GO:0045815","properties":[{"key":"GoTerm","value":"P:transcription initiation-coupled chromatin remodeling"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16322561"}]},{"database":"GO","id":"GO:0033209","properties":[{"key":"GoTerm","value":"P:tumor necrosis factor-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IGI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"22499991"}]},{"database":"GO","id":"GO:0060333","properties":[{"key":"GoTerm","value":"P:type II interferon-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0016032","properties":[{"key":"GoTerm","value":"P:viral process"},{"key":"GoEvidenceType","value":"IMP:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22574148"}]},{"database":"CDD","id":"cd08367","properties":[{"key":"EntryName","value":"P53"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP00086","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.60.40.720:FF:000003","properties":[{"key":"EntryName","value":"Cellular tumor antigen p53"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.170.10:FF:000003","properties":[{"key":"EntryName","value":"Cellular tumor antigen p53"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.720","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.50.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.170.10","properties":[{"key":"EntryName","value":"p53-like tetramerisation domain"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00015","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR008967","properties":[{"key":"EntryName","value":"p53-like_TF_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR012346","properties":[{"key":"EntryName","value":"p53/RUNT-type_TF_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR057064","properties":[{"key":"EntryName","value":"P53_central_site"}]},{"database":"InterPro","id":"IPR011615","properties":[{"key":"EntryName","value":"p53_DNA-bd"}]},{"database":"InterPro","id":"IPR040926","properties":[{"key":"EntryName","value":"p53_TAD2"}]},{"database":"InterPro","id":"IPR036674","properties":[{"key":"EntryName","value":"p53_tetramer_sf"}]},{"database":"InterPro","id":"IPR010991","properties":[{"key":"EntryName","value":"p53_tetrameristn"}]},{"database":"InterPro","id":"IPR013872","properties":[{"key":"EntryName","value":"p53_transactivation_domain"}]},{"database":"InterPro","id":"IPR002117","properties":[{"key":"EntryName","value":"p53_tumour_suppressor"}]},{"database":"PANTHER","id":"PTHR11447","properties":[{"key":"EntryName","value":"CELLULAR TUMOR ANTIGEN P53"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11447:SF6","properties":[{"key":"EntryName","value":"CELLULAR TUMOR ANTIGEN P53"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00870","properties":[{"key":"EntryName","value":"P53"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08563","properties":[{"key":"EntryName","value":"P53_TAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07710","properties":[{"key":"EntryName","value":"P53_tetramer"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18521","properties":[{"key":"EntryName","value":"TAD2"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00386","properties":[{"key":"EntryName","value":"P53SUPPRESSR"}]},{"database":"SUPFAM","id":"SSF47719","properties":[{"key":"EntryName","value":"p53 tetramerization domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49417","properties":[{"key":"EntryName","value":"p53-like transcription factors"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00348","properties":[{"key":"EntryName","value":"P53"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD","length":393,"molWeight":43653,"crc64":"AD5C149FD8106131","md5":"C133DFCE69F606F20865E9008199F852"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"SUBUNIT":5,"INTERACTION":187,"SUBCELLULAR LOCATION":8,"ALTERNATIVE PRODUCTS":9,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":2,"PTM":8,"DISEASE":9,"MISCELLANEOUS":5,"SIMILARITY":1,"CAUTION":1,"WEB RESOURCE":4},"countByFeatureType":{"Chain":1,"DNA binding":1,"Region":20,"Motif":5,"Compositional bias":3,"Binding site":4,"Site":1,"Modified residue":30,"Cross-link":6,"Alternative sequence":6,"Natural variant":1363,"Mutagenesis":38,"Helix":21,"Turn":7,"Beta strand":17},"uniParcId":"UPI000002ED67"}}