{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P04626","secondaryAccessions":["B2RZG3","B4DHN3","Q14256","Q6LDV1","Q9UMK4","X5D2V5"],"uniProtkbId":"ERBB2_HUMAN","entryAudit":{"firstPublicDate":"1987-08-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1987-08-13","entryVersion":284,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Receptor tyrosine-protein kinase erbB-2"},"ecNumbers":[{"value":"2.7.10.1"}]},"alternativeNames":[{"fullName":{"value":"Metastatic lymph node gene 19 protein"},"shortNames":[{"value":"MLN 19"}]},{"fullName":{"value":"Proto-oncogene Neu"}},{"fullName":{"value":"Proto-oncogene c-ErbB-2"}},{"fullName":{"value":"Tyrosine kinase-type cell surface receptor HER2"}},{"fullName":{"value":"p185erbB2"}}],"cdAntigenNames":[{"value":"CD340"}],"flag":"Precursor"},"genes":[{"geneName":{"value":"ERBB2"},"synonyms":[{"value":"HER2"},{"value":"MLN19"},{"value":"NEU"},{"value":"NGL"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15380516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21555369"}],"value":"In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10596"},{"database":"Rhea","id":"RHEA-COMP:10136"},{"database":"Rhea","id":"RHEA-COMP:20101"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:46858"},{"database":"ChEBI","id":"CHEBI:61978"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.10.1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10028"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21454582"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18719096"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21454582"}],"value":"Activated by dimerization. Not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P70424"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10805725"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12939402"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12975581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15093539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15156151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15210733"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16314522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16978839"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18719096"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20010870"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21190959"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21454582"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21555369"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26517842"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31138794"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32381043"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36949068"}],"value":"Homodimer (PubMed:21454582). Heterodimer with EGFR, ERBB3 and ERBB4 (PubMed:10358079, PubMed:15093539, PubMed:16978839, PubMed:21190959). Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196 (PubMed:10805725). Interacts with PLXNB1 (PubMed:15210733). Interacts (when phosphorylated on Tyr-1248) with MEMO1 (PubMed:15156151). Interacts with MUC1; the interaction is enhanced by heregulin (HRG) (PubMed:12939402). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain) (PubMed:12975581). Interacts (when phosphorylated on Tyr-1248) with ERBIN (PubMed:12444095). Interacts with KPNB1, RANBP2, EEA1, CRM1 and CLTC (PubMed:16314522). Interacts with PTK6 (PubMed:18719096). Interacts with RPA194 and ACTB (PubMed:21555369). Interacts with PRKCABP, SRC and MYOC (By similarity). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (PubMed:20010870). Interacts with HSP90AA1 and HSP90AB1 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (PubMed:26517842). Interacts with SORL1; this interaction regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulates ERBB2-mediated signaling (PubMed:31138794). Interacts with SH3BGRL (PubMed:32381043). Interacts with ROR1 (PubMed:36949068)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P00519","geneName":"ABL1","intActId":"EBI-375543"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P42684","geneName":"ABL2","intActId":"EBI-1102694"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P15309","geneName":"ACP3","intActId":"EBI-1222012"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P60709","geneName":"ACTB","intActId":"EBI-353944"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q92625","geneName":"ANKS1A","intActId":"EBI-1048612"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O00213","geneName":"APBB1","intActId":"EBI-81694"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P84085","geneName":"ARF5","intActId":"EBI-4289908"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O75815","geneName":"BCAR3","intActId":"EBI-702336"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9HB71","geneName":"CACYBP","intActId":"EBI-1047302"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q16543","geneName":"CDC37","intActId":"EBI-295634"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9NSE2","geneName":"CISH","intActId":"EBI-617866"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q7Z7G1","geneName":"CLNK","intActId":"EBI-7878194"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P46109","geneName":"CRKL","intActId":"EBI-910"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q93034","geneName":"CUL5","intActId":"EBI-1057139"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q15700","geneName":"DLG2","intActId":"EBI-80426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q99704","geneName":"DOK1","intActId":"EBI-1384360"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q8TEW6","geneName":"DOK4","intActId":"EBI-6918542"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q15075","geneName":"EEA1","intActId":"EBI-298113"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P98172","geneName":"EFNB1","intActId":"EBI-538287"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":25,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P04626","geneName":"ERBB2","intActId":"EBI-641062"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P21860","geneName":"ERBB3","intActId":"EBI-720706"},"numberOfExperiments":30,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q15303","geneName":"ERBB4","intActId":"EBI-80371"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9UJM3","geneName":"ERRFI1","intActId":"EBI-2941912"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P09769","geneName":"FGR","intActId":"EBI-1383732"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P06241","geneName":"FYN","intActId":"EBI-515315"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O75791","geneName":"GRAP2","intActId":"EBI-740418"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P62993","geneName":"GRB2","intActId":"EBI-401755"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q14451","geneName":"GRB7","intActId":"EBI-970191"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P07900","geneName":"HSP90AA1","intActId":"EBI-296047"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P08238","geneName":"HSP90AB1","intActId":"EBI-352572"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P14625","geneName":"HSP90B1","intActId":"EBI-359129"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P11021","geneName":"HSPA5","intActId":"EBI-354921"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P46940","geneName":"IQGAP1","intActId":"EBI-297509"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P35568","geneName":"IRS1","intActId":"EBI-517592"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q08881","geneName":"ITK","intActId":"EBI-968552"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P23458","geneName":"JAK1","intActId":"EBI-1383438"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q14974","geneName":"KPNB1","intActId":"EBI-286758"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q96JA1","geneName":"LRIG1","intActId":"EBI-2865191"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q96NW7","geneName":"LRRC7","intActId":"EBI-524275"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O75367","geneName":"MACROH2A1","intActId":"EBI-2868511"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O75367-3","geneName":"MACROH2A1","intActId":"EBI-6250866"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q96QZ7","geneName":"MAGI1","intActId":"EBI-924464"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9UQF2","geneName":"MAPK8IP1","intActId":"EBI-78404"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q13387","geneName":"MAPK8IP2","intActId":"EBI-722813"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P42679","geneName":"MATK","intActId":"EBI-751664"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9Y316","geneName":"MEMO1","intActId":"EBI-1104564"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O43639","geneName":"NCK2","intActId":"EBI-713635"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q02297-7","geneName":"NRG1","intActId":"EBI-2460927"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q5T2W1","geneName":"PDZK1","intActId":"EBI-349819"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O00750","geneName":"PIK3C2B","intActId":"EBI-641107"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P27986","geneName":"PIK3R1","intActId":"EBI-79464"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O00459","geneName":"PIK3R2","intActId":"EBI-346930"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q92569","geneName":"PIK3R3","intActId":"EBI-79893"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P19174","geneName":"PLCG1","intActId":"EBI-79387"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P16885","geneName":"PLCG2","intActId":"EBI-617403"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O95602","geneName":"POLR1A","intActId":"EBI-359472"},"numberOfExperiments":16,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q13882","geneName":"PTK6","intActId":"EBI-1383632"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q06124","geneName":"PTPN11","intActId":"EBI-297779"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q05209","geneName":"PTPN12","intActId":"EBI-2266035"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q99952","geneName":"PTPN18","intActId":"EBI-1384210"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q99952-1","geneName":"PTPN18","intActId":"EBI-12739708"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P26045","geneName":"PTPN3","intActId":"EBI-1047946"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P23467","geneName":"PTPRB","intActId":"EBI-1265766"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P08575","geneName":"PTPRC","intActId":"EBI-1341"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q12913","geneName":"PTPRJ","intActId":"EBI-2264500"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q15262","geneName":"PTPRK","intActId":"EBI-474052"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q16827","geneName":"PTPRO","intActId":"EBI-723739"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q15256","geneName":"PTPRR","intActId":"EBI-2265659"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P49792","geneName":"RANBP2","intActId":"EBI-973138"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P20936","geneName":"RASA1","intActId":"EBI-1026476"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O95980","geneName":"RECK","intActId":"EBI-2823742"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q14160","geneName":"SCRIB","intActId":"EBI-357345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9NP31","geneName":"SH2D2A","intActId":"EBI-490630"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P29353","geneName":"SHC1","intActId":"EBI-78835"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P98077","geneName":"SHC2","intActId":"EBI-7256023"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q92529","geneName":"SHC3","intActId":"EBI-79084"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9H6Q3","geneName":"SLA2","intActId":"EBI-1222854"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O15524","geneName":"SOCS1","intActId":"EBI-968198"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O43791","geneName":"SPOP","intActId":"EBI-743549"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P12931","geneName":"SRC","intActId":"EBI-621482"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P42224","geneName":"STAT1","intActId":"EBI-1057697"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P40763","geneName":"STAT3","intActId":"EBI-518675"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P31948","geneName":"STIP1","intActId":"EBI-1054052"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q7KZ85","geneName":"SUPT6H","intActId":"EBI-2515547"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P43405","geneName":"SYK","intActId":"EBI-78302"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9Y490","geneName":"TLN1","intActId":"EBI-2462036"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q63HR2","geneName":"TNS2","intActId":"EBI-949753"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q68CZ2","geneName":"TNS3","intActId":"EBI-1220488"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P10599","geneName":"TXN","intActId":"EBI-594644"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q96D37","geneName":"VAV1","intActId":"EBI-7875353"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P52735","geneName":"VAV2","intActId":"EBI-297549"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"Q9P202","geneName":"WHRN","intActId":"EBI-310886"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"O14980","geneName":"XPO1","intActId":"EBI-355867"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04626","intActId":"EBI-641062"},"interactantTwo":{"uniProtKBAccession":"P62258","geneName":"YWHAE","intActId":"EBI-356498"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32381043"}],"value":"Internalized from the cell membrane in response to EGF stimulation"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32381043"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34380438"}],"value":"Cell projection, ruffle membrane","id":"SL-0301"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31138794"}],"value":"Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31138794"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33497358"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31138794"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"value":"Cytoplasm, perinuclear region","id":"SL-0198"}},{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}},{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 3","subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}},{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing","Alternative initiation"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"ERBB2"},{"value":"HER2"}],"isoformIds":["P04626-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"CTF-611"}],"isoformIds":["P04626-2"],"sequenceIds":["VSP_039249"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"CTF-687"}],"isoformIds":["P04626-3"],"sequenceIds":["VSP_039250"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P04626-4"],"sequenceIds":["VSP_039248"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["P04626-5"],"sequenceIds":["VSP_054787"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"value":"B"}],"isoformIds":["P04626-6"],"sequenceIds":["VSP_055902","VSP_055903","VSP_055904"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15380516"}],"value":"Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17554007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27134172"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33497358"},{"evidenceCode":"ECO:0000305"}],"value":"Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172, PubMed:33497358). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172)"}],"commentType":"PTM"},{"texts":[{"value":"There are four alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency of 0.012"}],"commentType":"POLYMORPHISM"},{"commentType":"DISEASE","disease":{"diseaseId":"Glioma","diseaseAccession":"DI-02566","acronym":"GLM","description":"Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.","diseaseCrossReference":{"database":"MIM","id":"137800"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"}]},"note":{"texts":[{"value":"The gene represented in this entry is involved in disease pathogenesis"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Ovarian cancer","diseaseAccession":"DI-01655","acronym":"OC","description":"The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.","diseaseCrossReference":{"database":"MIM","id":"167000"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}]},"note":{"texts":[{"value":"The gene represented in this entry is involved in disease pathogenesis"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Lung cancer","diseaseAccession":"DI-02205","acronym":"LNCR","description":"A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.","diseaseCrossReference":{"database":"MIM","id":"211980"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"}]},"note":{"texts":[{"value":"The gene represented in this entry is involved in disease pathogenesis"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Gastric cancer","diseaseAccession":"DI-02971","acronym":"GASC","description":"A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.","diseaseCrossReference":{"database":"MIM","id":"613659"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}]},"note":{"texts":[{"value":"The protein represented in this entry is involved in disease pathogenesis"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21097718"}],"value":"Chromosomal aberrations involving ERBB2 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with CDK12, leading to CDK12-ERBB2 fusion leading to truncated CDK12 protein not in-frame with ERBB2"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Visceral neuropathy, familial, 2, autosomal recessive","diseaseAccession":"DI-06182","acronym":"VSCN2","description":"An autosomal recessive disorder characterized by intestinal dysmotility due to aganglionosis (Hirschsprung disease), hypoganglionosis, and/or chronic intestinal pseudoobstruction. Patients also show peripheral axonal neuropathy, hypotonia, mild developmental delay, unilateral ptosis, and sensorineural hearing loss.","diseaseCrossReference":{"database":"MIM","id":"619465"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33497358"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative initiation at Met-611 of isoform 1"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative initiation at Met-687 of isoform 1"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative splicing of isoform 1"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 4"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/162/ERBB2","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/ERBB2","ftp":false,"note":"ERBB2 entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":1255,"modifier":"EXACT"}},"description":"Receptor tyrosine-protein kinase erbB-2","featureId":"PRO_0000016669"},{"type":"Topological domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":652,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":1255,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":720,"modifier":"EXACT"},"end":{"value":987,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}]},{"type":"Region","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":689,"modifier":"EXACT"}},"description":"Required for interaction with KPNB1 and EEA1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16314522"}]},{"type":"Region","location":{"start":{"value":1035,"modifier":"EXACT"},"end":{"value":1179,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1195,"modifier":"EXACT"},"end":{"value":1197,"modifier":"EXACT"}},"description":"Interaction with PIK3C2B","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":1196,"modifier":"EXACT"},"end":{"value":1255,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":689,"modifier":"EXACT"}},"description":"Nuclear localization signal"},{"type":"Compositional bias","location":{"start":{"value":1146,"modifier":"EXACT"},"end":{"value":1155,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":845,"modifier":"EXACT"},"end":{"value":845,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10028"}]},{"type":"Binding site","location":{"start":{"value":726,"modifier":"EXACT"},"end":{"value":734,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":753,"modifier":"EXACT"},"end":{"value":753,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":877,"modifier":"EXACT"},"end":{"value":877,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32381043"}]},{"type":"Modified residue","location":{"start":{"value":1054,"modifier":"EXACT"},"end":{"value":1054,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":1078,"modifier":"EXACT"},"end":{"value":1078,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P06494"}]},{"type":"Modified residue","location":{"start":{"value":1083,"modifier":"EXACT"},"end":{"value":1083,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1107,"modifier":"EXACT"},"end":{"value":1107,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1112,"modifier":"EXACT"},"end":{"value":1112,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27134172"}]},{"type":"Modified residue","location":{"start":{"value":1139,"modifier":"EXACT"},"end":{"value":1139,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27134172"}]},{"type":"Modified residue","location":{"start":{"value":1151,"modifier":"EXACT"},"end":{"value":1151,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":1166,"modifier":"EXACT"},"end":{"value":1166,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1196,"modifier":"EXACT"},"end":{"value":1196,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27134172"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32381043"}]},{"type":"Modified residue","location":{"start":{"value":1248,"modifier":"EXACT"},"end":{"value":1248,"modifier":"EXACT"}},"description":"Phosphotyrosine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17554007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27134172"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"}]},{"type":"Glycosylation","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20696930"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15093539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19299620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20696930"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15093539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19299620"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":571,"modifier":"EXACT"},"end":{"value":571,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20696930"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":629,"modifier":"EXACT"},"end":{"value":629,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3H3B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRM"}]},{"type":"Disulfide bond","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3H3B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRM"}]},{"type":"Disulfide bond","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3H3B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRM"}]},{"type":"Disulfide bond","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3H3B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRM"}]},{"type":"Disulfide bond","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":504,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":511,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":515,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2A91"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"}]},{"type":"Disulfide bond","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRN"}]},{"type":"Disulfide bond","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":560,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRN"}]},{"type":"Disulfide bond","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":576,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRN"}]},{"type":"Disulfide bond","location":{"start":{"value":567,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WLW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WSQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRN"}]},{"type":"Disulfide bond","location":{"start":{"value":587,"modifier":"EXACT"},"end":{"value":596,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1S78"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3MZW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4HRN"}]},{"type":"Disulfide bond","location":{"start":{"value":600,"modifier":"EXACT"},"end":{"value":623,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1N8Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3BE1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"}]},{"type":"Disulfide bond","location":{"start":{"value":626,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"}]},{"type":"Disulfide bond","location":{"start":{"value":630,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3N85"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":686,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_039250","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_039249","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_054787","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_039248","alternativeSequence":{"originalSequence":"MELAALCRWGLLLALLPPGAAST","alternativeSequences":["MPRGSWKP"]}},{"type":"Alternative sequence","location":{"start":{"value":633,"modifier":"EXACT"},"end":{"value":648,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24722188"}],"featureId":"VSP_055902","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":771,"modifier":"EXACT"},"end":{"value":883,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24722188"}],"featureId":"VSP_055903","alternativeSequence":{"originalSequence":"AYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGK","alternativeSequences":["TISNLFSNFAPRGPSACCEPTCWCHSGKGQDSLPREEWGRQRRFCLWGCRGEPRVLDTPGRSCPSAPPSSCLQPSLRQPLLLGPGPTRAGGSTQHLQRDTYGREPRVPGSGRASVNQKAKSAEALMCPQGAGKA"]}},{"type":"Alternative sequence","location":{"start":{"value":884,"modifier":"EXACT"},"end":{"value":1255,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24722188"}],"featureId":"VSP_055904","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"in dbSNP:rs4252633","featureCrossReferences":[{"database":"dbSNP","id":"rs4252633"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_016317","alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"in allele B3; dbSNP:rs1801201","featureCrossReferences":[{"database":"dbSNP","id":"rs1801201"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8095488"}],"featureId":"VAR_004077","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":655,"modifier":"EXACT"},"end":{"value":655,"modifier":"EXACT"}},"description":"in allele B2 and allele B3; dbSNP:rs1136201","featureCrossReferences":[{"database":"dbSNP","id":"rs1136201"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8095488"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_004078","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":710,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"in VSCN2; almost complete loss of ERBB2 and ERBB3 phosphorylation in the presence or in the absence of NRG1 stimulation, suggesting alteration of downstream signaling; does not affect the subcellular localization at the cell membrane; dbSNP:rs2145813505","featureCrossReferences":[{"database":"dbSNP","id":"rs2145813505"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33497358"}],"featureId":"VAR_086107","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":755,"modifier":"EXACT"},"end":{"value":755,"modifier":"EXACT"}},"description":"in LNCR; uncertain significance; somatic mutation; dbSNP:rs121913469","featureCrossReferences":[{"database":"dbSNP","id":"rs121913469"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"}],"featureId":"VAR_055432","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":768,"modifier":"EXACT"},"end":{"value":768,"modifier":"EXACT"}},"description":"in dbSNP:rs56366519","featureCrossReferences":[{"database":"dbSNP","id":"rs56366519"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042097","alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":774,"modifier":"EXACT"}},"description":"in LNCR; uncertain significance; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"}],"featureId":"VAR_055433","alternativeSequence":{"originalSequence":"M","alternativeSequences":["MAYVM"]}},{"type":"Natural variant","location":{"start":{"value":776,"modifier":"EXACT"},"end":{"value":776,"modifier":"EXACT"}},"description":"in GASC; uncertain significance; somatic mutation; dbSNP:rs28933369","featureCrossReferences":[{"database":"dbSNP","id":"rs28933369"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042098","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":779,"modifier":"EXACT"},"end":{"value":779,"modifier":"EXACT"}},"description":"in LNCR; uncertain significance; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"}],"featureId":"VAR_055434","alternativeSequence":{"originalSequence":"S","alternativeSequences":["SVGS"]}},{"type":"Natural variant","location":{"start":{"value":857,"modifier":"EXACT"},"end":{"value":857,"modifier":"EXACT"}},"description":"in OC; uncertain significance; somatic mutation; dbSNP:rs28933370","featureCrossReferences":[{"database":"dbSNP","id":"rs28933370"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042099","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":914,"modifier":"EXACT"},"end":{"value":914,"modifier":"EXACT"}},"description":"in GLM; uncertain significance; somatic mutation; dbSNP:rs28933368","featureCrossReferences":[{"database":"dbSNP","id":"rs28933368"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15457249"}],"featureId":"VAR_055435","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":1170,"modifier":"EXACT"},"end":{"value":1170,"modifier":"EXACT"}},"description":"in dbSNP:rs1058808","featureCrossReferences":[{"database":"dbSNP","id":"rs1058808"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2999974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8104414"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_016318","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":1216,"modifier":"EXACT"},"end":{"value":1216,"modifier":"EXACT"}},"description":"in dbSNP:rs55943169","featureCrossReferences":[{"database":"dbSNP","id":"rs55943169"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042100","alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Reduces dimerization with ERBB3.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15093539"}],"alternativeSequence":{"originalSequence":"LH","alternativeSequences":["AA"]}},{"type":"Mutagenesis","location":{"start":{"value":611,"modifier":"EXACT"},"end":{"value":611,"modifier":"EXACT"}},"description":"Prevents synthesis of isoform 2.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16794579"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":687,"modifier":"EXACT"},"end":{"value":687,"modifier":"EXACT"}},"description":"Prevents synthesis of isoform 3.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16794579"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":706,"modifier":"EXACT"},"end":{"value":706,"modifier":"EXACT"}},"description":"No effect on isoform production.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16794579"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":712,"modifier":"EXACT"},"end":{"value":712,"modifier":"EXACT"}},"description":"No effect on isoform production.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16794579"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["A"]}},{"type":"Beta strand","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Helix","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Helix","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Beta strand","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Beta strand","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Beta strand","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3H3B"}]},{"type":"Turn","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Beta strand","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Beta strand","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PWH"}]},{"type":"Turn","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3H3B"}]},{"type":"Beta strand","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3H3B"}]},{"type":"Beta strand","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A91"}]},{"type":"Beta strand","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Helix","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Helix","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Helix","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1N8Z"}]},{"type":"Beta strand","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Helix","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Helix","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Beta strand","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Helix","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYR"}]},{"type":"Helix","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1S78"}]},{"type":"Beta strand","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1N8Z"}]},{"type":"Helix","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Helix","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Turn","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Turn","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6J71"}]},{"type":"Beta strand","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1N8Z"}]},{"type":"Beta strand","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VQD"}]},{"type":"Beta strand","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A91"}]},{"type":"Helix","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Turn","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Helix","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Helix","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Helix","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Helix","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Helix","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PWH"}]},{"type":"Helix","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3WLW"}]},{"type":"Turn","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":469,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Turn","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VQE"}]},{"type":"Helix","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VQD"}]},{"type":"Beta strand","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Helix","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Turn","location":{"start":{"value":507,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N85"}]},{"type":"Helix","location":{"start":{"value":516,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Beta strand","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5MY6"}]},{"type":"Helix","location":{"start":{"value":525,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A91"}]},{"type":"Beta strand","location":{"start":{"value":532,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LBX"}]},{"type":"Beta strand","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":542,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LBX"}]},{"type":"Beta strand","location":{"start":{"value":545,"modifier":"EXACT"},"end":{"value":551,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LBX"}]},{"type":"Beta strand","location":{"start":{"value":553,"modifier":"EXACT"},"end":{"value":556,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LBX"}]},{"type":"Beta strand","location":{"start":{"value":559,"modifier":"EXACT"},"end":{"value":562,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LBX"}]},{"type":"Beta strand","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":567,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3WSQ"}]},{"type":"Beta strand","location":{"start":{"value":571,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LBX"}]},{"type":"Beta strand","location":{"start":{"value":575,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LBX"}]},{"type":"Beta strand","location":{"start":{"value":583,"modifier":"EXACT"},"end":{"value":592,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LBX"}]},{"type":"Beta strand","location":{"start":{"value":595,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LBX"}]},{"type":"Beta strand","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6J71"}]},{"type":"Beta strand","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":608,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PWH"}]},{"type":"Beta strand","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JYQ"}]},{"type":"Beta strand","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":625,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1N8Z"}]},{"type":"Beta strand","location":{"start":{"value":630,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6J71"}]},{"type":"Beta strand","location":{"start":{"value":635,"modifier":"EXACT"},"end":{"value":637,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6J71"}]},{"type":"Beta strand","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":643,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8Q6J"}]},{"type":"Helix","location":{"start":{"value":651,"modifier":"EXACT"},"end":{"value":678,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JWA"}]},{"type":"Helix","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":690,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N2A"}]},{"type":"Helix","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":697,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N2A"}]},{"type":"Helix","location":{"start":{"value":717,"modifier":"EXACT"},"end":{"value":719,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Beta strand","location":{"start":{"value":720,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Beta strand","location":{"start":{"value":732,"modifier":"EXACT"},"end":{"value":739,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Beta strand","location":{"start":{"value":748,"modifier":"EXACT"},"end":{"value":755,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":761,"modifier":"EXACT"},"end":{"value":774,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Beta strand","location":{"start":{"value":775,"modifier":"EXACT"},"end":{"value":777,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Beta strand","location":{"start":{"value":785,"modifier":"EXACT"},"end":{"value":799,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":806,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Turn","location":{"start":{"value":813,"modifier":"EXACT"},"end":{"value":816,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":819,"modifier":"EXACT"},"end":{"value":838,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":848,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Beta strand","location":{"start":{"value":851,"modifier":"EXACT"},"end":{"value":855,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Beta strand","location":{"start":{"value":858,"modifier":"EXACT"},"end":{"value":861,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":866,"modifier":"EXACT"},"end":{"value":870,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8U8X"}]},{"type":"Beta strand","location":{"start":{"value":874,"modifier":"EXACT"},"end":{"value":877,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":878,"modifier":"EXACT"},"end":{"value":880,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8U8X"}]},{"type":"Helix","location":{"start":{"value":886,"modifier":"EXACT"},"end":{"value":888,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":891,"modifier":"EXACT"},"end":{"value":896,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":901,"modifier":"EXACT"},"end":{"value":916,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Turn","location":{"start":{"value":922,"modifier":"EXACT"},"end":{"value":925,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":928,"modifier":"EXACT"},"end":{"value":930,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":931,"modifier":"EXACT"},"end":{"value":937,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":941,"modifier":"EXACT"},"end":{"value":944,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":949,"modifier":"EXACT"},"end":{"value":958,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":963,"modifier":"EXACT"},"end":{"value":965,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":969,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":983,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VB5"}]},{"type":"Helix","location":{"start":{"value":989,"modifier":"EXACT"},"end":{"value":992,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3PP0"}]},{"type":"Helix","location":{"start":{"value":1003,"modifier":"EXACT"},"end":{"value":1007,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3PP0"}]},{"type":"Turn","location":{"start":{"value":1008,"modifier":"EXACT"},"end":{"value":1011,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8U8X"}]},{"type":"Helix","location":{"start":{"value":1020,"modifier":"EXACT"},"end":{"value":1022,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8U8X"}]},{"type":"Beta strand","location":{"start":{"value":1140,"modifier":"EXACT"},"end":{"value":1142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1MW4"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0024","category":"Coding sequence diversity","name":"Alternative initiation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0829","category":"Molecular function","name":"Tyrosine-protein kinase"}],"references":[{"referenceNumber":1,"citation":{"id":"3003577","citationType":"journal article","authors":["Yamamoto T.","Ikawa S.","Akiyama T.","Semba K.","Nomura N.","Miyajima N.","Saito T.","Toyoshima K."],"citationCrossReferences":[{"database":"PubMed","id":"3003577"},{"database":"DOI","id":"10.1038/319230a0"}],"title":"Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.","publicationDate":"1986","journal":"Nature","firstPage":"230","lastPage":"234","volume":"319"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"2999974","citationType":"journal article","authors":["Coussens L.","Yang-Feng T.L.","Liao Y.C.","Chen E.","Gray A.","McGrath J.","Seeburg P.H.","Libermann T.A.","Schlessinger J.","Francke U.","Levinson A.","Ullrich A."],"citationCrossReferences":[{"database":"PubMed","id":"2999974"},{"database":"DOI","id":"10.1126/science.2999974"}],"title":"Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.","publicationDate":"1985","journal":"Science","firstPage":"1132","lastPage":"1139","volume":"230"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)","VARIANT ALA-1170"]},{"referenceNumber":3,"citation":{"id":"CI-6QAL73TV67LMT","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"DEC-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS CYS-452; VAL-655 AND ALA-1170"]},{"referenceNumber":4,"citation":{"id":"CI-2ELFNBL2J9UAG","citationType":"submission","authors":["Wakamatsu A.","Yamamoto J.","Kimura K.","Ishii S.","Watanabe K.","Sugiyama A.","Murakawa K.","Kaida T.","Tsuchiya K.","Fukuzumi Y.","Kumagai A.","Oishi Y.","Yamamoto S.","Ono Y.","Komori Y.","Yamazaki M.","Kisu Y.","Nishikawa T.","Sugano S.","Nomura N.","Isogai T."],"title":"NEDO human cDNA sequencing project focused on splicing variants.","publicationDate":"OCT-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":7,"citation":{"id":"3039351","citationType":"journal article","authors":["Tal M.","King C.R.","Kraus M.H.","Ullrich A.","Schlessinger J.","Givol D."],"citationCrossReferences":[{"database":"PubMed","id":"3039351"},{"database":"DOI","id":"10.1128/mcb.7.7.2597-2601.1987"}],"title":"Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation.","publicationDate":"1987","journal":"Mol. Cell. Biol.","firstPage":"2597","lastPage":"2601","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-191 (ISOFORM 1)"]},{"referenceNumber":8,"citation":{"id":"24722188","citationType":"journal article","authors":["Corominas R.","Yang X.","Lin G.N.","Kang S.","Shen Y.","Ghamsari L.","Broly M.","Rodriguez M.","Tam S.","Wanamaker S.A.","Fan C.","Yi S.","Tasan M.","Lemmens I.","Kuang X.","Zhao N.","Malhotra D.","Michaelson J.J.","Vacic V.","Calderwood M.A.","Roth F.P.","Tavernier J.","Horvath S.","Salehi-Ashtiani K.","Korkin D.","Sebat J.","Hill D.E.","Hao T.","Vidal M.","Iakoucheva L.M."],"citationCrossReferences":[{"database":"PubMed","id":"24722188"},{"database":"DOI","id":"10.1038/ncomms4650"}],"title":"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"3650","lastPage":"3650","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-867 (ISOFORM 6)"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"2995967","citationType":"journal article","authors":["Semba K.","Kamata N.","Toyoshima K.","Yamamoto T."],"citationCrossReferences":[{"database":"PubMed","id":"2995967"},{"database":"DOI","id":"10.1073/pnas.82.19.6497"}],"title":"A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.","publicationDate":"1985","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6497","lastPage":"6501","volume":"82"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 737-1031"]},{"referenceNumber":10,"citation":{"id":"2992089","citationType":"journal article","authors":["King C.R.","Kraus M.H.","Aaronson S.A."],"citationCrossReferences":[{"database":"PubMed","id":"2992089"},{"database":"DOI","id":"10.1126/science.2992089"}],"title":"Amplification of a novel v-erbB-related gene in a human mammary carcinoma.","publicationDate":"1985","journal":"Science","firstPage":"974","lastPage":"976","volume":"229"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 832-909"],"referenceComments":[{"value":"Mammary carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"8104414","citationType":"journal article","authors":["Sarkar F.H.","Ball D.E.","Li Y.W.","Crissman J.D."],"citationCrossReferences":[{"database":"PubMed","id":"8104414"},{"database":"DOI","id":"10.1089/dna.1993.12.611"}],"title":"Molecular cloning and sequencing of an intron of Her-2/neu (ERBB2) gene.","publicationDate":"1993","journal":"DNA Cell Biol.","firstPage":"611","lastPage":"615","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE OF 1081-1245","VARIANT ALA-1170"]},{"referenceNumber":12,"citation":{"id":"10358079","citationType":"journal article","authors":["Olayioye M.A.","Beuvink I.","Horsch K.","Daly J.M.","Hynes N.E."],"citationCrossReferences":[{"database":"PubMed","id":"10358079"},{"database":"DOI","id":"10.1074/jbc.274.24.17209"}],"title":"ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"17209","lastPage":"17218","volume":"274"},"referencePositions":["INTERACTION WITH ERBB4","FUNCTION IN ACTIVATION OF STAT5A"]},{"referenceNumber":13,"citation":{"id":"10805725","citationType":"journal article","authors":["Arcaro A.","Zvelebil M.J.","Wallasch C.","Ullrich A.","Waterfield M.D.","Domin J."],"citationCrossReferences":[{"database":"PubMed","id":"10805725"},{"database":"DOI","id":"10.1128/mcb.20.11.3817-3830.2000"}],"title":"Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.","publicationDate":"2000","journal":"Mol. Cell. Biol.","firstPage":"3817","lastPage":"3830","volume":"20"},"referencePositions":["IDENTIFICATION IN A COMPLEX WITH PIK3C2A AND EGFR","IDENTIFICATION IN A COMPLEX WITH PIK3C2B AND EGFR","INTERACTION WITH PIK3C2B"]},{"referenceNumber":14,"citation":{"id":"12939402","citationType":"journal article","authors":["Li Y.","Yu W.-H.","Ren J.","Chen W.","Huang L.","Kharbanda S.","Loda M.","Kufe D."],"citationCrossReferences":[{"database":"PubMed","id":"12939402"}],"title":"Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.","publicationDate":"2003","journal":"Mol. Cancer Res.","firstPage":"765","lastPage":"775","volume":"1"},"referencePositions":["INTERACTION WITH MUC1"]},{"referenceNumber":15,"citation":{"id":"15380516","citationType":"journal article","authors":["Wang S.C.","Lien H.C.","Xia W.","Chen I.F.","Lo H.W.","Wang Z.","Ali-Seyed M.","Lee D.F.","Bartholomeusz G.","Ou-Yang F.","Giri D.K.","Hung M.C."],"citationCrossReferences":[{"database":"PubMed","id":"15380516"},{"database":"DOI","id":"10.1016/j.ccr.2004.07.012"}],"title":"Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.","publicationDate":"2004","journal":"Cancer Cell","firstPage":"251","lastPage":"261","volume":"6"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":16,"citation":{"id":"15210733","citationType":"journal article","authors":["Swiercz J.M.","Kuner R.","Offermanns S."],"citationCrossReferences":[{"database":"PubMed","id":"15210733"},{"database":"DOI","id":"10.1083/jcb.200312094"}],"title":"Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.","publicationDate":"2004","journal":"J. Cell Biol.","firstPage":"869","lastPage":"880","volume":"165"},"referencePositions":["INTERACTION WITH PLXNB1"]},{"referenceNumber":17,"citation":{"id":"15156151","citationType":"journal article","authors":["Marone R.","Hess D.","Dankort D.","Muller W.J.","Hynes N.E.","Badache A."],"citationCrossReferences":[{"database":"PubMed","id":"15156151"},{"database":"DOI","id":"10.1038/ncb1134"}],"title":"Memo mediates ErbB2-driven cell motility.","publicationDate":"2004","journal":"Nat. Cell Biol.","firstPage":"515","lastPage":"522","volume":"6"},"referencePositions":["INTERACTION WITH MEMO1"]},{"referenceNumber":18,"citation":{"id":"16314522","citationType":"journal article","authors":["Giri D.K.","Ali-Seyed M.","Li L.Y.","Lee D.F.","Ling P.","Bartholomeusz G.","Wang S.C.","Hung M.C."],"citationCrossReferences":[{"database":"PubMed","id":"16314522"},{"database":"DOI","id":"10.1128/mcb.25.24.11005-11018.2005"}],"title":"Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.","publicationDate":"2005","journal":"Mol. Cell. Biol.","firstPage":"11005","lastPage":"11018","volume":"25"},"referencePositions":["SUBCELLULAR LOCATION","NUCLEAR LOCALIZATION SIGNAL","INTERACTION WITH KPNB1; RANBP2; CRM1; EEA1 AND CLTC"]},{"referenceNumber":19,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1248","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":20,"citation":{"id":"16794579","citationType":"journal article","authors":["Anido J.","Scaltriti M.","Bech Serra J.J.","Santiago Josefat B.","Todo F.R.","Baselga J.","Arribas J."],"citationCrossReferences":[{"database":"PubMed","id":"16794579"},{"database":"DOI","id":"10.1038/sj.emboj.7601191"}],"title":"Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation.","publicationDate":"2006","journal":"EMBO J.","firstPage":"3234","lastPage":"3244","volume":"25"},"referencePositions":["FUNCTION","ALTERNATIVE INITIATION (ISOFORMS 2 AND 3)","SUBCELLULAR LOCATION","MUTAGENESIS OF MET-611; MET-687; MET-706 AND MET-712"]},{"referenceNumber":21,"citation":{"id":"16978839","citationType":"journal article","authors":["Li Z.","Mei Y.","Liu X.","Zhou M."],"citationCrossReferences":[{"database":"PubMed","id":"16978839"},{"database":"DOI","id":"10.1016/j.cellsig.2006.07.020"}],"title":"Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners.","publicationDate":"2007","journal":"Cell. Signal.","firstPage":"466","lastPage":"471","volume":"19"},"referencePositions":["INTERACTION WITH ERBB4","AUTOPHOSPHORYLATION IN TRANS"]},{"referenceNumber":22,"citation":{"id":"17554007","citationType":"journal article","authors":["Deng S.","Hirschberg A.","Worzfeld T.","Penachioni J.Y.","Korostylev A.","Swiercz J.M.","Vodrazka P.","Mauti O.","Stoeckli E.T.","Tamagnone L.","Offermanns S.","Kuner R."],"citationCrossReferences":[{"database":"PubMed","id":"17554007"},{"database":"DOI","id":"10.1523/jneurosci.5381-06.2007"}],"title":"Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo.","publicationDate":"2007","journal":"J. Neurosci.","firstPage":"6333","lastPage":"6347","volume":"27"},"referencePositions":["PHOSPHORYLATION AT TYR-1248"]},{"referenceNumber":23,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":25,"citation":{"id":"18719096","citationType":"journal article","authors":["Xiang B.","Chatti K.","Qiu H.","Lakshmi B.","Krasnitz A.","Hicks J.","Yu M.","Miller W.T.","Muthuswamy S.K."],"citationCrossReferences":[{"database":"PubMed","id":"18719096"},{"database":"DOI","id":"10.1073/pnas.0805009105"}],"title":"Brk is coamplified with ErbB2 to promote proliferation in breast cancer.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12463","lastPage":"12468","volume":"105"},"referencePositions":["INTERACTION WITH PTK6","ACTIVITY REGULATION"]},{"referenceNumber":26,"citation":{"id":"19372587","citationType":"journal article","authors":["Hawthorne V.S.","Huang W.C.","Neal C.L.","Tseng L.M.","Hung M.C.","Yu D."],"citationCrossReferences":[{"database":"PubMed","id":"19372587"},{"database":"DOI","id":"10.1158/1541-7786.mcr-08-0316"}],"title":"ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.","publicationDate":"2009","journal":"Mol. Cancer Res.","firstPage":"592","lastPage":"600","volume":"7"},"referencePositions":["FUNCTION IN NUCLEUS"]},{"referenceNumber":27,"citation":{"id":"20010870","citationType":"journal article","authors":["Heinrich C.","Keller C.","Boulay A.","Vecchi M.","Bianchi M.","Sack R.","Lienhard S.","Duss S.","Hofsteenge J.","Hynes N.E."],"citationCrossReferences":[{"database":"PubMed","id":"20010870"},{"database":"DOI","id":"10.1038/onc.2009.456"}],"title":"Copine-III interacts with ErbB2 and promotes tumor cell migration.","publicationDate":"2010","journal":"Oncogene","firstPage":"1598","lastPage":"1610","volume":"29"},"referencePositions":["INTERACTION WITH CPNE3"]},{"referenceNumber":28,"citation":{"id":"20937854","citationType":"journal article","authors":["Zaoui K.","Benseddik K.","Daou P.","Salaun D.","Badache A."],"citationCrossReferences":[{"database":"PubMed","id":"20937854"},{"database":"DOI","id":"10.1073/pnas.1000975107"}],"title":"ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"18517","lastPage":"18522","volume":"107"},"referencePositions":["FUNCTION"]},{"referenceNumber":29,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":30,"citation":{"id":"21097718","citationType":"journal article","authors":["Zang Z.J.","Ong C.K.","Cutcutache I.","Yu W.","Zhang S.L.","Huang D.","Ler L.D.","Dykema K.","Gan A.","Tao J.","Lim S.","Liu Y.","Futreal P.A.","Grabsch H.","Furge K.A.","Goh L.K.","Rozen S.","Teh B.T.","Tan P."],"citationCrossReferences":[{"database":"PubMed","id":"21097718"},{"database":"DOI","id":"10.1158/0008-5472.can-10-1749"}],"title":"Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.","publicationDate":"2011","journal":"Cancer Res.","firstPage":"29","lastPage":"39","volume":"71"},"referencePositions":["CHROMOSOMAL REARRANGEMENT WITH CDK12"]},{"referenceNumber":31,"citation":{"id":"21555369","citationType":"journal article","authors":["Li L.Y.","Chen H.","Hsieh Y.H.","Wang Y.N.","Chu H.J.","Chen Y.H.","Chen H.Y.","Chien P.J.","Ma H.T.","Tsai H.C.","Lai C.C.","Sher Y.P.","Lien H.C.","Tsai C.H.","Hung M.C."],"citationCrossReferences":[{"database":"PubMed","id":"21555369"},{"database":"DOI","id":"10.1158/0008-5472.can-10-3504"}],"title":"Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.","publicationDate":"2011","journal":"Cancer Res.","firstPage":"4269","lastPage":"4279","volume":"71"},"referencePositions":["FUNCTION IN NUCLEUS","INTERACTION WITH ACTB AND RPA194","SUBCELLULAR LOCATION"]},{"referenceNumber":32,"citation":{"id":"21190959","citationType":"journal article","authors":["Kharmate G.","Rajput P.S.","Watt H.L.","Somvanshi R.K.","Chaudhari N.","Qiu X.","Kumar U."],"citationCrossReferences":[{"database":"PubMed","id":"21190959"},{"database":"DOI","id":"10.1210/en.2010-0940"}],"title":"Dissociation of epidermal growth factor receptor and ErbB2 heterodimers in the presence of somatostatin receptor 5 modulate signaling pathways.","publicationDate":"2011","journal":"Endocrinology","firstPage":"931","lastPage":"945","volume":"152"},"referencePositions":["INTERACTION WITH EGFR"]},{"referenceNumber":33,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":34,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182; SER-1054; SER-1083 AND THR-1166","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":35,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054 AND SER-1151","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":36,"citation":{"id":"26517842","citationType":"journal article","authors":["Prince T.L.","Kijima T.","Tatokoro M.","Lee S.","Tsutsumi S.","Yim K.","Rivas C.","Alarcon S.","Schwartz H.","Khamit-Kush K.","Scroggins B.T.","Beebe K.","Trepel J.B.","Neckers L."],"citationCrossReferences":[{"database":"PubMed","id":"26517842"},{"database":"DOI","id":"10.1371/journal.pone.0141786"}],"title":"Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.","publicationDate":"2015","journal":"PLoS ONE","firstPage":"E0141786","lastPage":"E0141786","volume":"10"},"referencePositions":["INTERACTION WITH HSP90AA1 AND HSP90AB1"]},{"referenceNumber":37,"citation":{"id":"27134172","citationType":"journal article","authors":["Li H.","Yang F.","Liu C.","Xiao P.","Xu Y.","Liang Z.","Liu C.","Wang H.","Wang W.","Zheng W.","Zhang W.","Ma X.","He D.","Song X.","Cui F.","Xu Z.","Yi F.","Sun J.P.","Yu X."],"citationCrossReferences":[{"database":"PubMed","id":"27134172"},{"database":"DOI","id":"10.1016/j.celrep.2016.04.016"}],"title":"Crystal structure and substrate specificity of PTPN12.","publicationDate":"2016","journal":"Cell Rep.","firstPage":"1345","lastPage":"1358","volume":"15"},"referencePositions":["PHOSPHORYLATION AT TYR-1112; TYR-1139; TYR-1196 AND TYR-1248","DEPHOSPHORYLATION BY PTPN12"]},{"referenceNumber":38,"citation":{"id":"31138794","citationType":"journal article","authors":["Pietilae M.","Sahgal P.","Peuhu E.","Jaentti N.Z.","Paatero I.","Naervae E.","Al-Akhrass H.","Lilja J.","Georgiadou M.","Andersen O.M.","Padzik A.","Sihto H.","Joensuu H.","Blomqvist M.","Saarinen I.","Bostroem P.J.","Taimen P.","Ivaska J."],"citationCrossReferences":[{"database":"PubMed","id":"31138794"},{"database":"DOI","id":"10.1038/s41467-019-10275-0"}],"title":"SORLA regulates endosomal trafficking and oncogenic fitness of HER2.","publicationDate":"2019","journal":"Nat. Commun.","firstPage":"2340","lastPage":"2340","volume":"10"},"referencePositions":["INTERACTION WITH SORL1","SUBCELLULAR LOCATION"]},{"referenceNumber":39,"citation":{"id":"32381043","citationType":"journal article","authors":["Li H.","Zhang M.","Wei Y.","Haider F.","Lin Y.","Guan W.","Liu Y.","Zhang S.","Yuan R.","Yang X.","Yang S.","Wang H."],"citationCrossReferences":[{"database":"PubMed","id":"32381043"},{"database":"DOI","id":"10.1186/s13046-020-01577-z"}],"title":"SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.","publicationDate":"2020","journal":"J. Exp. Clin. Cancer Res.","firstPage":"81","lastPage":"81","volume":"39"},"referencePositions":["INTERACTION WITH SH3BGRL","SUBCELLULAR LOCATION","PHOSPHORYLATION AT TYR-877 AND TYR-1196"]},{"referenceNumber":40,"citation":{"id":"34380438","citationType":"journal article","authors":["Di Pisa F.","Pesenti E.","Bono M.","Mazzarello A.N.","Bernardi C.","Lisanti M.P.","Renzone G.","Scaloni A.","Ciccone E.","Fais F.","Bruno S.","Scartezzini P.","Ghiotto F."],"citationCrossReferences":[{"database":"PubMed","id":"34380438"},{"database":"DOI","id":"10.1186/s12860-021-00379-1"}],"title":"SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.","publicationDate":"2021","journal":"BMC Mol. Cell Biol.","firstPage":"41","lastPage":"41","volume":"22"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":41,"citation":{"id":"36949068","citationType":"journal article","authors":["Lin W.","Niu R.","Park S.M.","Zou Y.","Kim S.S.","Xia X.","Xing S.","Yang Q.","Sun X.","Yuan Z.","Zhou S.","Zhang D.","Kwon H.J.","Park S.","Il Kim C.","Koo H.","Liu Y.","Wu H.","Zheng M.","Yoo H.","Shi B.","Park J.B.","Yin J."],"citationCrossReferences":[{"database":"PubMed","id":"36949068"},{"database":"DOI","id":"10.1038/s41467-023-37306-1"}],"title":"IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.","publicationDate":"2023","journal":"Nat. Commun.","firstPage":"1578","lastPage":"1578","volume":"14"},"referencePositions":["INTERACTION WITH ROR1"]},{"referenceNumber":42,"citation":{"id":"10593938","citationType":"journal article","authors":["Kuhns J.J.","Batalia M.A.","Yan S.","Collins E.J."],"citationCrossReferences":[{"database":"PubMed","id":"10593938"},{"database":"DOI","id":"10.1074/jbc.274.51.36422"}],"title":"Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"36422","lastPage":"36427","volume":"274"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH HLA AND BETA-2 MICROGLOBULIN"]},{"referenceNumber":43,"citation":{"id":"12444095","citationType":"journal article","authors":["Birrane G.","Chung J.","Ladias J.A."],"citationCrossReferences":[{"database":"PubMed","id":"12444095"},{"database":"DOI","id":"10.1074/jbc.c200571200"}],"title":"Novel mode of ligand recognition by the Erbin PDZ domain.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"1399","lastPage":"1402","volume":"278"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH ERBIN","INTERACTION WITH ERBIN"]},{"referenceNumber":44,"citation":{"id":"12975581","citationType":"journal article","authors":["Ivancic M.","Daly R.J.","Lyons B.A."],"citationCrossReferences":[{"database":"PubMed","id":"12975581"},{"database":"DOI","id":"10.1023/a:1025498409113"}],"title":"Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.","publicationDate":"2003","journal":"J. Biomol. NMR","firstPage":"205","lastPage":"219","volume":"27"},"referencePositions":["STRUCTURE BY NMR OF 1135-1144 IN COMPLEX WITH GRB7","INTERACTION WITH GRB7"]},{"referenceNumber":45,"citation":{"id":"12610629","citationType":"journal article","authors":["Cho H.-S.","Mason K.","Ramyar K.X.","Stanley A.M.","Gabelli S.B.","Denney D.W. Jr.","Leahy D.J."],"citationCrossReferences":[{"database":"PubMed","id":"12610629"},{"database":"DOI","id":"10.1038/nature01392"}],"title":"Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.","publicationDate":"2003","journal":"Nature","firstPage":"756","lastPage":"760","volume":"421"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH THE ANTIBODY HERCEPTIN"]},{"referenceNumber":46,"citation":{"id":"15093539","citationType":"journal article","authors":["Franklin M.C.","Carey K.D.","Vajdos F.F.","Leahy D.J.","de Vos A.M.","Sliwkowski M.X."],"citationCrossReferences":[{"database":"PubMed","id":"15093539"},{"database":"DOI","id":"10.1016/s1535-6108(04)00083-2"}],"title":"Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.","publicationDate":"2004","journal":"Cancer Cell","firstPage":"317","lastPage":"328","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH THE ANTIBODY PERTUZUMAB","INTERACTION WITH ERBB3","MUTAGENESIS OF 317-LEU-HIS-318","DISULFIDE BONDS","GLYCOSYLATION AT ASN-187; ASN-259 AND ASN-530"]},{"referenceNumber":47,"citation":{"id":"19299620","citationType":"journal article","authors":["Bostrom J.","Yu S.F.","Kan D.","Appleton B.A.","Lee C.V.","Billeci K.","Man W.","Peale F.","Ross S.","Wiesmann C.","Fuh G."],"citationCrossReferences":[{"database":"PubMed","id":"19299620"},{"database":"DOI","id":"10.1126/science.1165480"}],"title":"Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site.","publicationDate":"2009","journal":"Science","firstPage":"1610","lastPage":"1614","volume":"323"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH THE ANTIBODY HERCEPTIN","DISULFIDE BONDS","GLYCOSYLATION AT ASN-259 AND ASN-530"]},{"referenceNumber":48,"citation":{"id":"20696930","citationType":"journal article","authors":["Eigenbrot C.","Ultsch M.","Dubnovitsky A.","Abrahmsen L.","Hard T."],"citationCrossReferences":[{"database":"PubMed","id":"20696930"},{"database":"DOI","id":"10.1073/pnas.1005025107"}],"title":"Structural basis for high-affinity HER2 receptor binding by an engineered protein.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15039","lastPage":"15044","volume":"107"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH ENGINEERED ANTIBODY ZHER2","DISULFIDE BONDS","GLYCOSYLATION AT ASN-68; ASN-259 AND ASN-571"]},{"referenceNumber":49,"citation":{"id":"21454582","citationType":"journal article","authors":["Aertgeerts K.","Skene R.","Yano J.","Sang B.C.","Zou H.","Snell G.","Jennings A.","Iwamoto K.","Habuka N.","Hirokawa A.","Ishikawa T.","Tanaka T.","Miki H.","Ohta Y.","Sogabe S."],"citationCrossReferences":[{"database":"PubMed","id":"21454582"},{"database":"DOI","id":"10.1074/jbc.m110.206193"}],"title":"Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"18756","lastPage":"18765","volume":"286"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH INHIBITOR SYR127063","CATALYTIC ACTIVITY","SUBUNIT","ACTIVITY REGULATION"]},{"referenceNumber":50,"citation":{"id":"8095488","citationType":"journal article","authors":["Ehsani A.","Low J.","Wallace R.B.","Wu A.M."],"citationCrossReferences":[{"database":"PubMed","id":"8095488"},{"database":"DOI","id":"10.1006/geno.1993.1081"}],"title":"Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization.","publicationDate":"1993","journal":"Genomics","firstPage":"426","lastPage":"429","volume":"15"},"referencePositions":["VARIANTS VAL-654 AND VAL-655"]},{"referenceNumber":51,"citation":{"id":"15457249","citationType":"journal article","authoringGroup":["Cancer genome project and collaborative group"],"authors":["Stephens P.","Hunter C.","Bignell G.","Edkins S.","Davies H.","Teague J.","Stevens C.","O'Meara S.","Smith R.","Parker A.","Barthorpe A.","Blow M.","Brackenbury L.","Butler A.","Clarke O.","Cole J.","Dicks E.","Dike A.","Drozd A.","Edwards K.","Forbes S.","Foster R.","Gray K.","Greenman C.","Halliday K.","Hills K.","Kosmidou V.","Lugg R.","Menzies A.","Perry J.","Petty R.","Raine K.","Ratford L.","Shepherd R.","Small A.","Stephens Y.","Tofts C.","Varian J.","West S.","Widaa S.","Yates A.","Brasseur F.","Cooper C.S.","Flanagan A.M.","Knowles M.","Leung S.Y.","Louis D.N.","Looijenga L.H.","Malkowicz B.","Pierotti M.A.","Teh B.","Chenevix-Trench G.","Weber B.L.","Yuen S.T.","Harris G.","Goldstraw P.","Nicholson A.G.","Futreal P.A.","Wooster R.","Stratton M.R."],"citationCrossReferences":[{"database":"PubMed","id":"15457249"},{"database":"DOI","id":"10.1038/431525b"}],"title":"Lung cancer: intragenic ERBB2 kinase mutations in tumours.","publicationDate":"2004","journal":"Nature","firstPage":"525","lastPage":"526","volume":"431"},"referencePositions":["INVOLVEMENT IN CANCER","VARIANT GASC SER-776","VARIANT OC SER-857","VARIANT GLM LYS-914","VARIANTS LNCR PRO-755; ALA-TYR-VAL-MET-774 INS AND VAL-GLY-SER-779 INS"]},{"referenceNumber":52,"citation":{"id":"17344846","citationType":"journal article","authors":["Greenman C.","Stephens P.","Smith R.","Dalgliesh G.L.","Hunter C.","Bignell G.","Davies H.","Teague J.","Butler A.","Stevens C.","Edkins S.","O'Meara S.","Vastrik I.","Schmidt E.E.","Avis T.","Barthorpe S.","Bhamra G.","Buck G.","Choudhury B.","Clements J.","Cole J.","Dicks E.","Forbes S.","Gray K.","Halliday K.","Harrison R.","Hills K.","Hinton J.","Jenkinson A.","Jones D.","Menzies A.","Mironenko T.","Perry J.","Raine K.","Richardson D.","Shepherd R.","Small A.","Tofts C.","Varian J.","Webb T.","West S.","Widaa S.","Yates A.","Cahill D.P.","Louis D.N.","Goldstraw P.","Nicholson A.G.","Brasseur F.","Looijenga L.","Weber B.L.","Chiew Y.-E.","DeFazio A.","Greaves M.F.","Green A.R.","Campbell P.","Birney E.","Easton D.F.","Chenevix-Trench G.","Tan M.-H.","Khoo S.K.","Teh B.T.","Yuen S.T.","Leung S.Y.","Wooster R.","Futreal P.A.","Stratton M.R."],"citationCrossReferences":[{"database":"PubMed","id":"17344846"},{"database":"DOI","id":"10.1038/nature05610"}],"title":"Patterns of somatic mutation in human cancer genomes.","publicationDate":"2007","journal":"Nature","firstPage":"153","lastPage":"158","volume":"446"},"referencePositions":["VARIANTS [LARGE SCALE ANALYSIS] VAL-654; VAL-655; SER-768; ALA-1170 AND ASP-1216","VARIANT GASC SER-776","VARIANT OC SER-857"]},{"referenceNumber":53,"citation":{"id":"33497358","citationType":"journal article","authors":["Le T.L.","Galmiche L.","Levy J.","Suwannarat P.","Hellebrekers D.M.","Morarach K.","Boismoreau F.","Theunissen T.E.","Lefebvre M.","Pelet A.","Martinovic J.","Gelot A.","Guimiot F.","Calleroz A.","Gitiaux C.","Hully M.","Goulet O.","Chardot C.","Drunat S.","Capri Y.","Bole-Feysot C.","Nitschke P.","Whalen S.","Mouthon L.","Babcock H.E.","Hofstra R.","de Coo I.F.","Tabet A.C.","Molina T.J.","Keren B.","Brooks A.","Smeets H.J.","Marklund U.","Gordon C.T.","Lyonnet S.","Amiel J.","Bondurand N."],"citationCrossReferences":[{"database":"PubMed","id":"33497358"},{"database":"DOI","id":"10.1172/jci145837"}],"title":"Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans.","publicationDate":"2021","journal":"J. Clin. Invest.","firstPage":"0","lastPage":"0","volume":"131"},"referencePositions":["INVOLVEMENT IN VSCN2","VARIANT VSCN2 VAL-710","CHARACTERIZATION OF VARIANT VSCN2 VAL-710","SUBCELLULAR LOCATION","PHOSPHORYLATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AH001455","properties":[{"key":"ProteinId","value":"AAA35808.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X03363","properties":[{"key":"ProteinId","value":"CAA27060.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M11730","properties":[{"key":"ProteinId","value":"AAA75493.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M12036","properties":[{"key":"ProteinId","value":"AAA35978.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY208911","properties":[{"key":"ProteinId","value":"AAO18082.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK295195","properties":[{"key":"ProteinId","value":"BAG58195.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471152","properties":[{"key":"ProteinId","value":"EAW60597.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC167147","properties":[{"key":"ProteinId","value":"AAI67147.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M16792","properties":[{"key":"ProteinId","value":"AAA58637.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M16789","properties":[{"key":"ProteinId","value":"AAA58637.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M16790","properties":[{"key":"ProteinId","value":"AAA58637.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M16791","properties":[{"key":"ProteinId","value":"AAA58637.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KJ534964","properties":[{"key":"ProteinId","value":"AHW56604.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L29395","properties":[{"key":"ProteinId","value":"AAA35809.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M95667","properties":[{"key":"ProteinId","value":"AAC37531.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS32642.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04626-1"},{"database":"CCDS","id":"CCDS45667.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04626-5"},{"database":"CCDS","id":"CCDS74052.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04626-4"},{"database":"PIR","id":"A24571","properties":[{"key":"EntryName","value":"A24571"}]},{"database":"RefSeq","id":"NP_001005862.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001005862.3"}],"isoformId":"P04626-5"},{"database":"RefSeq","id":"NP_001276865.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001289936.2"}],"isoformId":"P04626-4"},{"database":"RefSeq","id":"NP_001276867.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001289938.2"}]},{"database":"RefSeq","id":"NP_001369711.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001382782.1"}],"isoformId":"P04626-5"},{"database":"RefSeq","id":"NP_001369712.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001382783.1"}],"isoformId":"P04626-5"},{"database":"RefSeq","id":"NP_004439.2","properties":[{"key":"NucleotideSequenceId","value":"NM_004448.4"}],"isoformId":"P04626-1"},{"database":"RefSeq","id":"XP_047291546.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047435590.1"}],"isoformId":"P04626-4"},{"database":"PDB","id":"1MFG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.25 A"},{"key":"Chains","value":"B=1247-1255"}]},{"database":"PDB","id":"1MFL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"B=1247-1255"}]},{"database":"PDB","id":"1MW4","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=1135-1144"}]},{"database":"PDB","id":"1N8Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.52 A"},{"key":"Chains","value":"C=23-629"}]},{"database":"PDB","id":"1QR1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"C/F=654-662"}]},{"database":"PDB","id":"1S78","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.25 A"},{"key":"Chains","value":"A/B=23-646"}]},{"database":"PDB","id":"2A91","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=22-530"}]},{"database":"PDB","id":"2JWA","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=641-684"}]},{"database":"PDB","id":"2KS1","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=641-684"}]},{"database":"PDB","id":"2L4K","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=1135-1144"}]},{"database":"PDB","id":"2N2A","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=644-700"}]},{"database":"PDB","id":"3BE1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=23-646"}]},{"database":"PDB","id":"3H3B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A/B=23-214"}]},{"database":"PDB","id":"3MZW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=23-646"}]},{"database":"PDB","id":"3N85","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=23-646"}]},{"database":"PDB","id":"3PP0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A/B=703-1047"}]},{"database":"PDB","id":"3RCD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.21 A"},{"key":"Chains","value":"A/B/C/D=713-1028"}]},{"database":"PDB","id":"3WLW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.09 A"},{"key":"Chains","value":"A/B=23-586"}]},{"database":"PDB","id":"3WSQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A=23-586"}]},{"database":"PDB","id":"4GFU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"F=1246-1252"}]},{"database":"PDB","id":"4HRL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"C=24-219"}]},{"database":"PDB","id":"4HRM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/C=24-219"}]},{"database":"PDB","id":"4HRN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"C/D=529-625"}]},{"database":"PDB","id":"4NND","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"C/E/F/H=1109-1114"}]},{"database":"PDB","id":"5K33","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"C=23-629"}]},{"database":"PDB","id":"5KWG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.30 A"},{"key":"Chains","value":"C=23-653"}]},{"database":"PDB","id":"5MY6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A=24-645"}]},{"database":"PDB","id":"5O4G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"C=23-628"}]},{"database":"PDB","id":"5OB4","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=641-684"}]},{"database":"PDB","id":"5TQS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"E/F/G/H=1218-1228"}]},{"database":"PDB","id":"6ATT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.77 A"},{"key":"Chains","value":"A=23-652"}]},{"database":"PDB","id":"6BGT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"C=1-652"}]},{"database":"PDB","id":"6J71","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.92 A"},{"key":"Chains","value":"A=22-639"}]},{"database":"PDB","id":"6LBX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"B=531-626"}]},{"database":"PDB","id":"6OGE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.36 A"},{"key":"Chains","value":"A=23-644"}]},{"database":"PDB","id":"7JXH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.27 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=703-1024"}]},{"database":"PDB","id":"7MN5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.93 A"},{"key":"Chains","value":"B=1-1029"}]},{"database":"PDB","id":"7MN6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.09 A"},{"key":"Chains","value":"B=1-1029"}]},{"database":"PDB","id":"7MN8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.45 A"},{"key":"Chains","value":"B=1-1029"}]},{"database":"PDB","id":"7PCD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.77 A"},{"key":"Chains","value":"A=703-1029"}]},{"database":"PDB","id":"7QVK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"AAA=23-646"}]},{"database":"PDB","id":"8FFJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.50 A"},{"key":"Chains","value":"X=23-644"}]},{"database":"PDB","id":"8HGO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.31 A"},{"key":"Chains","value":"B=1-693"}]},{"database":"PDB","id":"8HGP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.53 A"},{"key":"Chains","value":"B=1-693"}]},{"database":"PDB","id":"8JYQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"C/F=611-618"}]},{"database":"PDB","id":"8JYR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A=23-216"}]},{"database":"PDB","id":"8PWH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.17 A"},{"key":"Chains","value":"E=23-646"}]},{"database":"PDB","id":"8Q6J","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"E=23-646"}]},{"database":"PDB","id":"8U4K","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.27 A"},{"key":"Chains","value":"B=24-629"}]},{"database":"PDB","id":"8U4L","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.31 A"},{"key":"Chains","value":"B=24-629"}]},{"database":"PDB","id":"8U8X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A=694-1029"}]},{"database":"PDB","id":"8VB5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.48 A"},{"key":"Chains","value":"A=703-1029"}]},{"database":"PDB","id":"8VQD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.61 A"},{"key":"Chains","value":"A=23-652"}]},{"database":"PDB","id":"8VQE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.67 A"},{"key":"Chains","value":"A/B=23-652"}]},{"database":"PDB","id":"9IUT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"C/F=611-618"}]},{"database":"PDB","id":"9L1S","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A=23-652"}]},{"database":"PDB","id":"9MTE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.66 A"},{"key":"Chains","value":"C=23-652"}]},{"database":"PDB","id":"9MTX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.06 A"},{"key":"Chains","value":"B=23-652"}]},{"database":"PDB","id":"9QBF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A=23-1029"}]},{"database":"PDB","id":"9QBG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A=23-1029"}]},{"database":"PDB","id":"9QBH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.77 A"},{"key":"Chains","value":"A=23-1029"}]},{"database":"PDB","id":"9T3R","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A=23-652"}]},{"database":"PDB","id":"9T3S","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A=23-652"}]},{"database":"AlphaFoldDB","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17993","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-18188","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-18189","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-18190","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20055","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29044","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34744","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34745","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-41885","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-41886","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43439","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43440","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48606","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48615","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-55517","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-55518","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62753","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108376","properties":[{"key":"Interactions","value":"884"}]},{"database":"CORUM","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-8N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P04626","properties":[{"key":"Number of interactors","value":"2287"}]},{"database":"IntAct","id":"P04626","properties":[{"key":"Interactions","value":"862"}]},{"database":"MINT","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-ERBB2","properties":[{"key":"Evidences","value":"40 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000269571","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1824","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB08916","properties":[{"key":"GenericName","value":"Afatinib"}]},{"database":"DrugBank","id":"DB06021","properties":[{"key":"GenericName","value":"AV-412"}]},{"database":"DrugBank","id":"DB12318","properties":[{"key":"GenericName","value":"BMS-599626"}]},{"database":"DrugBank","id":"DB11665","properties":[{"key":"GenericName","value":"BMS-690514"}]},{"database":"DrugBank","id":"DB12267","properties":[{"key":"GenericName","value":"Brigatinib"}]},{"database":"DrugBank","id":"DB05424","properties":[{"key":"GenericName","value":"Canertinib"}]},{"database":"DrugBank","id":"DB12302","properties":[{"key":"GenericName","value":"CP-724714"}]},{"database":"DrugBank","id":"DB12174","properties":[{"key":"GenericName","value":"CUDC-101"}]},{"database":"DrugBank","id":"DB11963","properties":[{"key":"GenericName","value":"Dacomitinib"}]},{"database":"DrugBank","id":"DB12010","properties":[{"key":"GenericName","value":"Fostamatinib"}]},{"database":"DrugBank","id":"DB04988","properties":[{"key":"GenericName","value":"IGN311"}]},{"database":"DrugBank","id":"DB01259","properties":[{"key":"GenericName","value":"Lapatinib"}]},{"database":"DrugBank","id":"DB14967","properties":[{"key":"GenericName","value":"Margetuximab"}]},{"database":"DrugBank","id":"DB00179","properties":[{"key":"GenericName","value":"Masoprocol"}]},{"database":"DrugBank","id":"DB04862","properties":[{"key":"GenericName","value":"Merimepodib"}]},{"database":"DrugBank","id":"DB12682","properties":[{"key":"GenericName","value":"Mubritinib"}]},{"database":"DrugBank","id":"DB06226","properties":[{"key":"GenericName","value":"Nelipepimut-S"}]},{"database":"DrugBank","id":"DB11828","properties":[{"key":"GenericName","value":"Neratinib"}]},{"database":"DrugBank","id":"DB07662","properties":[{"key":"GenericName","value":"PD-168393"}]},{"database":"DrugBank","id":"DB06366","properties":[{"key":"GenericName","value":"Pertuzumab"}]},{"database":"DrugBank","id":"DB12114","properties":[{"key":"GenericName","value":"Poziotinib"}]},{"database":"DrugBank","id":"DB12183","properties":[{"key":"GenericName","value":"Sapitinib"}]},{"database":"DrugBank","id":"DB21667","properties":[{"key":"GenericName","value":"Sevabertinib"}]},{"database":"DrugBank","id":"DB14944","properties":[{"key":"GenericName","value":"Tarloxotinib"}]},{"database":"DrugBank","id":"DB11973","properties":[{"key":"GenericName","value":"Tesevatinib"}]},{"database":"DrugBank","id":"DB00072","properties":[{"key":"GenericName","value":"Trastuzumab"}]},{"database":"DrugBank","id":"DB05773","properties":[{"key":"GenericName","value":"Trastuzumab emtansine"}]},{"database":"DrugBank","id":"DB11699","properties":[{"key":"GenericName","value":"Tropisetron"}]},{"database":"DrugBank","id":"DB11652","properties":[{"key":"GenericName","value":"Tucatinib"}]},{"database":"DrugBank","id":"DB21508","properties":[{"key":"GenericName","value":"Tuxobertinib"}]},{"database":"DrugBank","id":"DB05944","properties":[{"key":"GenericName","value":"Varlitinib"}]},{"database":"DrugBank","id":"DB15471","properties":[{"key":"GenericName","value":"Zanidatamab"}]},{"database":"DrugBank","id":"DB15035","properties":[{"key":"GenericName","value":"Zanubrutinib"}]},{"database":"DrugBank","id":"DB15559","properties":[{"key":"GenericName","value":"Zenocutuzumab"}]},{"database":"DrugBank","id":"DB18762","properties":[{"key":"GenericName","value":"Zongertinib"}]},{"database":"DrugCentral","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"2019","properties":[{"key":"Description","value":"-"}]},{"database":"MoonDB","id":"P04626","properties":[{"key":"Type","value":"Predicted"}]},{"database":"TCDB","id":"8.A.23.1.39","properties":[{"key":"FamilyName","value":"the basigin (basigin) family"}]},{"database":"CarbonylDB","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P04626","properties":[{"key":"glycosylation","value":"13 N-Linked glycans (5 sites), 1 O-Linked glycan (1 site)"}]},{"database":"GlyCosmos","id":"P04626","properties":[{"key":"glycosylation","value":"10 sites, 27 glycans"}]},{"database":"GlyGen","id":"P04626","properties":[{"key":"glycosylation","value":"10 sites, 27 N-linked glycans (7 sites), 2 O-linked glycans (2 sites)"}]},{"database":"iPTMnet","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ERBB2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"119533","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-192","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-193","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-194","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-195","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-3045","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-3046","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5777","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5827","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5839","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5864","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-693","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-5384","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-5385","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-5386","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-5547","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-5732","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-5733","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000269571","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51718","properties":[{"key":"Description","value":"-"}],"isoformId":"P04626-1"},{"database":"ProteomicsDB","id":"51719","properties":[{"key":"Description","value":"-"}],"isoformId":"P04626-2"},{"database":"ProteomicsDB","id":"51720","properties":[{"key":"Description","value":"-"}],"isoformId":"P04626-3"},{"database":"ProteomicsDB","id":"51721","properties":[{"key":"Description","value":"-"}],"isoformId":"P04626-4"},{"database":"Pumba","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P04626","properties":[{"key":"antibodies","value":"345 sequenced antibodies"}]},{"database":"Antibodypedia","id":"740","properties":[{"key":"antibodies","value":"7294 antibodies from 67 providers"}]},{"database":"CPTC","id":"P04626","properties":[{"key":"antibodies","value":"4 antibodies"}]},{"database":"DNASU","id":"2064","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000269571.10","properties":[{"key":"ProteinId","value":"ENSP00000269571.4"},{"key":"GeneId","value":"ENSG00000141736.15"}],"isoformId":"P04626-1"},{"database":"Ensembl","id":"ENST00000584601.5","properties":[{"key":"ProteinId","value":"ENSP00000462438.1"},{"key":"GeneId","value":"ENSG00000141736.15"}],"isoformId":"P04626-5"},{"database":"GeneID","id":"2064","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2064","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000269571.10","properties":[{"key":"ProteinId","value":"ENSP00000269571.4"},{"key":"RefSeqNucleotideId","value":"NM_004448.4"},{"key":"RefSeqProteinId","value":"NP_004439.2"}]},{"database":"UCSC","id":"uc060esv.1","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P04626-1"},{"database":"AGR","id":"HGNC:3430","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"2064","properties":[{"key":"Number of evidences","value":"2 clinical assertions and 315 evidence items across 186 molecular profiles"}]},{"database":"ClinPGx","id":"PA27844","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2064","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2064","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ERBB2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3430","properties":[{"key":"GeneName","value":"ERBB2"}]},{"database":"HPA","id":"ENSG00000141736","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"ERBB2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"137800","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"164870","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"167000","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"211980","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"613659","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"619465","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000141736","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"99976","properties":[{"key":"Disease","value":"Adenocarcinoma of the oesophagus and oesophagogastric junction"}]},{"database":"Orphanet","id":"2800","properties":[{"key":"Disease","value":"Extramammary Paget disease"}]},{"database":"Orphanet","id":"388","properties":[{"key":"Disease","value":"Hirschsprung disease"}]},{"database":"Orphanet","id":"213726","properties":[{"key":"Disease","value":"Serous carcinoma of the corpus uteri"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000141736","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1025","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158232","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AACAHYK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6219513at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P04626","properties":[{"key":"Number of GO annotations","value":"9 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.7.10.1","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1227986","properties":[{"key":"PathwayName","value":"Signaling by ERBB2"}]},{"database":"Reactome","id":"R-HSA-1250196","properties":[{"key":"PathwayName","value":"SHC1 events in ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-1251932","properties":[{"key":"PathwayName","value":"PLCG1 events in ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-1257604","properties":[{"key":"PathwayName","value":"PIP3 activates AKT signaling"}]},{"database":"Reactome","id":"R-HSA-1306955","properties":[{"key":"PathwayName","value":"GRB7 events in ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-1358803","properties":[{"key":"PathwayName","value":"Downregulation of ERBB2:ERBB3 signaling"}]},{"database":"Reactome","id":"R-HSA-1963640","properties":[{"key":"PathwayName","value":"GRB2 events in ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-1963642","properties":[{"key":"PathwayName","value":"PI3K events in ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-2219530","properties":[{"key":"PathwayName","value":"Constitutive Signaling by Aberrant PI3K in Cancer"}]},{"database":"Reactome","id":"R-HSA-416572","properties":[{"key":"PathwayName","value":"Sema4D induced cell migration and growth-cone collapse"}]},{"database":"Reactome","id":"R-HSA-5673001","properties":[{"key":"PathwayName","value":"RAF/MAP kinase cascade"}]},{"database":"Reactome","id":"R-HSA-6785631","properties":[{"key":"PathwayName","value":"ERBB2 Regulates Cell Motility"}]},{"database":"Reactome","id":"R-HSA-6811558","properties":[{"key":"PathwayName","value":"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"}]},{"database":"Reactome","id":"R-HSA-8847993","properties":[{"key":"PathwayName","value":"ERBB2 Activates PTK6 Signaling"}]},{"database":"Reactome","id":"R-HSA-8863795","properties":[{"key":"PathwayName","value":"Downregulation of ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-8866910","properties":[{"key":"PathwayName","value":"TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"}]},{"database":"Reactome","id":"R-HSA-9634285","properties":[{"key":"PathwayName","value":"Constitutive Signaling by Overexpressed ERBB2"}]},{"database":"Reactome","id":"R-HSA-9652282","properties":[{"key":"PathwayName","value":"Drug-mediated inhibition of ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-9664565","properties":[{"key":"PathwayName","value":"Signaling by ERBB2 KD Mutants"}]},{"database":"Reactome","id":"R-HSA-9665233","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to trastuzumab"}]},{"database":"Reactome","id":"R-HSA-9665244","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to sapitinib"}]},{"database":"Reactome","id":"R-HSA-9665245","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to tesevatinib"}]},{"database":"Reactome","id":"R-HSA-9665246","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to neratinib"}]},{"database":"Reactome","id":"R-HSA-9665247","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to osimertinib"}]},{"database":"Reactome","id":"R-HSA-9665249","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to afatinib"}]},{"database":"Reactome","id":"R-HSA-9665250","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to AEE788"}]},{"database":"Reactome","id":"R-HSA-9665251","properties":[{"key":"PathwayName","value":"Resistance of ERBB2 KD mutants to lapatinib"}]},{"database":"Reactome","id":"R-HSA-9665348","properties":[{"key":"PathwayName","value":"Signaling by ERBB2 ECD mutants"}]},{"database":"Reactome","id":"R-HSA-9665686","properties":[{"key":"PathwayName","value":"Signaling by ERBB2 TMD/JMD mutants"}]},{"database":"Reactome","id":"R-HSA-9665737","properties":[{"key":"PathwayName","value":"Drug resistance in ERBB2 TMD/JMD mutants"}]},{"database":"Reactome","id":"R-HSA-9927418","properties":[{"key":"PathwayName","value":"Developmental Lineage of Mammary Gland Luminal Epithelial Cells"}]},{"database":"Reactome","id":"R-HSA-9927432","properties":[{"key":"PathwayName","value":"Developmental Lineage of Mammary Gland Myoepithelial Cells"}]},{"database":"Reactome","id":"R-HSA-9938206","properties":[{"key":"PathwayName","value":"Developmental Lineage of Mammary Stem Cells"}]},{"database":"SignaLink","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000141736","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"2064","properties":[{"key":"hits","value":"92 hits in 1209 CRISPR screens"}]},{"database":"ChiTaRS","id":"ERBB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P04626","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"HER2/neu","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"2064","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P04626","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P04626","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"P04626","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000141736","properties":[{"key":"ExpressionPatterns","value":"Expressed in lower esophagus mucosa and 186 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P04626","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009925","properties":[{"key":"GoTerm","value":"C:basal plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016323","properties":[{"key":"GoTerm","value":"C:basolateral plasma membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12646923"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31138794"}]},{"database":"GO","id":"GO:0010008","properties":[{"key":"GoTerm","value":"C:endosome membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16314522"}]},{"database":"GO","id":"GO:0038143","properties":[{"key":"GoTerm","value":"C:ERBB3:ERBB2 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12000754"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15609325"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16314522"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21555369"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20010870"}]},{"database":"GO","id":"GO:0032587","properties":[{"key":"GoTerm","value":"C:ruffle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0002116","properties":[{"key":"GoTerm","value":"C:semaphorin receptor complex"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0043235","properties":[{"key":"GoTerm","value":"C:signaling receptor complex"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23382219"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7514177"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015026","properties":[{"key":"GoTerm","value":"F:coreceptor activity"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0043125","properties":[{"key":"GoTerm","value":"F:ErbB-3 class receptor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12000754"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12000754"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7556068"}]},{"database":"GO","id":"GO:0004713","properties":[{"key":"GoTerm","value":"F:protein tyrosine kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12000754"}]},{"database":"GO","id":"GO:0030971","properties":[{"key":"GoTerm","value":"F:receptor tyrosine kinase binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7556068"}]},{"database":"GO","id":"GO:0001042","properties":[{"key":"GoTerm","value":"F:RNA polymerase I core binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21555369"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7556068"}]},{"database":"GO","id":"GO:0004714","properties":[{"key":"GoTerm","value":"F:transmembrane receptor protein tyrosine kinase activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7514177"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7514177"}]},{"database":"GO","id":"GO:0008283","properties":[{"key":"GoTerm","value":"P:cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36949068"}]},{"database":"GO","id":"GO:0007169","properties":[{"key":"GoTerm","value":"P:cell surface receptor protein tyrosine kinase signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7514177"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7556068"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9685399"}]},{"database":"GO","id":"GO:0071364","properties":[{"key":"GoTerm","value":"P:cellular response to epidermal growth factor stimulus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27134172"}]},{"database":"GO","id":"GO:0071363","properties":[{"key":"GoTerm","value":"P:cellular response to growth factor stimulus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20010870"}]},{"database":"GO","id":"GO:0007167","properties":[{"key":"GoTerm","value":"P:enzyme-linked receptor protein signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9590694"}]},{"database":"GO","id":"GO:0007173","properties":[{"key":"GoTerm","value":"P:epidermal growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0038134","properties":[{"key":"GoTerm","value":"P:ERBB2-EGFR signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8702723"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19372587"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030182","properties":[{"key":"GoTerm","value":"P:neuron differentiation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0018108","properties":[{"key":"GoTerm","value":"P:peptidyl-tyrosine phosphorylation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12000754"}]},{"database":"GO","id":"GO:0043491","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7556068"}]},{"database":"GO","id":"GO:0045785","properties":[{"key":"GoTerm","value":"P:positive regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7556068"}]},{"database":"GO","id":"GO:0030307","properties":[{"key":"GoTerm","value":"P:positive regulation of cell growth"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21555369"}]},{"database":"GO","id":"GO:0050679","properties":[{"key":"GoTerm","value":"P:positive regulation of epithelial cell proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10572067"}]},{"database":"GO","id":"GO:0043406","properties":[{"key":"GoTerm","value":"P:positive regulation of MAP kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10572067"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0090314","properties":[{"key":"GoTerm","value":"P:positive regulation of protein targeting to membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20010870"}]},{"database":"GO","id":"GO:0035025","properties":[{"key":"GoTerm","value":"P:positive regulation of Rho protein signal transduction"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0045943","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase I"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21555369"}]},{"database":"GO","id":"GO:0045727","properties":[{"key":"GoTerm","value":"P:positive regulation of translation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21555369"}]},{"database":"GO","id":"GO:0006468","properties":[{"key":"GoTerm","value":"P:protein phosphorylation"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10851066"}]},{"database":"GO","id":"GO:0045765","properties":[{"key":"GoTerm","value":"P:regulation of angiogenesis"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15609325"}]},{"database":"GO","id":"GO:0070372","properties":[{"key":"GoTerm","value":"P:regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16314522"}]},{"database":"GO","id":"GO:0032886","properties":[{"key":"GoTerm","value":"P:regulation of microtubule-based process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20937854"}]},{"database":"GO","id":"GO:0071526","properties":[{"key":"GoTerm","value":"P:semaphorin-plexin signaling pathway"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10572067"}]},{"database":"GO","id":"GO:0042060","properties":[{"key":"GoTerm","value":"P:wound healing"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12646923"}]},{"database":"CDD","id":"cd00064","properties":[{"key":"EntryName","value":"FU"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd05109","properties":[{"key":"EntryName","value":"PTKc_HER2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd12094","properties":[{"key":"EntryName","value":"TM_ErbB2"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP01484","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"1.20.5.100:FF:000007","properties":[{"key":"EntryName","value":"Receptor protein-tyrosine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.220.10:FF:000010","properties":[{"key":"EntryName","value":"Receptor protein-tyrosine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000184","properties":[{"key":"EntryName","value":"Receptor protein-tyrosine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.80.20.20:FF:000007","properties":[{"key":"EntryName","value":"Receptor protein-tyrosine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.80.20.20:FF:000008","properties":[{"key":"EntryName","value":"Receptor protein-tyrosine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:002828","properties":[{"key":"EntryName","value":"Receptor tyrosine-protein kinase erbB-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.100","properties":[{"key":"EntryName","value":"Cytochrome c1, transmembrane anchor, C-terminal"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.220.10","properties":[{"key":"EntryName","value":"Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"4.10.1140.10","properties":[{"key":"EntryName","value":"membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.80.20.20","properties":[{"key":"EntryName","value":"Receptor L-domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00293","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR006211","properties":[{"key":"EntryName","value":"Furin-like_Cys-rich_dom"}]},{"database":"InterPro","id":"IPR006212","properties":[{"key":"EntryName","value":"Furin_repeat"}]},{"database":"InterPro","id":"IPR032778","properties":[{"key":"EntryName","value":"GF_recep_IV"}]},{"database":"InterPro","id":"IPR009030","properties":[{"key":"EntryName","value":"Growth_fac_rcpt_cys_sf"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR000494","properties":[{"key":"EntryName","value":"Rcpt_L-dom"}]},{"database":"InterPro","id":"IPR036941","properties":[{"key":"EntryName","value":"Rcpt_L-dom_sf"}]},{"database":"InterPro","id":"IPR050122","properties":[{"key":"EntryName","value":"RTK"}]},{"database":"InterPro","id":"IPR001245","properties":[{"key":"EntryName","value":"Ser-Thr/Tyr_kinase_cat_dom"}]},{"database":"InterPro","id":"IPR049328","properties":[{"key":"EntryName","value":"TM_ErbB1"}]},{"database":"InterPro","id":"IPR008266","properties":[{"key":"EntryName","value":"Tyr_kinase_AS"}]},{"database":"InterPro","id":"IPR020635","properties":[{"key":"EntryName","value":"Tyr_kinase_cat_dom"}]},{"database":"InterPro","id":"IPR016245","properties":[{"key":"EntryName","value":"Tyr_kinase_EGF/ERB/XmrK_rcpt"}]},{"database":"PANTHER","id":"PTHR24416:SF137","properties":[{"key":"EntryName","value":"RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24416","properties":[{"key":"EntryName","value":"TYROSINE-PROTEIN KINASE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00757","properties":[{"key":"EntryName","value":"Furin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14843","properties":[{"key":"EntryName","value":"GF_recep_IV"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07714","properties":[{"key":"EntryName","value":"PK_Tyr_Ser-Thr"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01030","properties":[{"key":"EntryName","value":"Recep_L_domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF21314","properties":[{"key":"EntryName","value":"TM_ErbB1"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000619","properties":[{"key":"EntryName","value":"TyrPK_EGF-R"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00109","properties":[{"key":"EntryName","value":"TYRKINASE"}]},{"database":"SMART","id":"SM00261","properties":[{"key":"EntryName","value":"FU"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00219","properties":[{"key":"EntryName","value":"TyrKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57184","properties":[{"key":"EntryName","value":"Growth factor receptor domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF52058","properties":[{"key":"EntryName","value":"L domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00109","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_TYR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV","length":1255,"molWeight":137910,"crc64":"39E9DFDA04DCF962","md5":"D89A90920775435179A0D5281A800F78"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":110,"SUBCELLULAR LOCATION":4,"ALTERNATIVE PRODUCTS":6,"TISSUE SPECIFICITY":1,"PTM":1,"POLYMORPHISM":1,"DISEASE":6,"MISCELLANEOUS":3,"SIMILARITY":1,"WEB RESOURCE":2},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":1,"Region":4,"Motif":1,"Compositional bias":1,"Active site":1,"Binding site":2,"Modified residue":12,"Glycosylation":7,"Disulfide bond":25,"Alternative sequence":7,"Natural variant":13,"Mutagenesis":5,"Beta strand":63,"Helix":45,"Turn":11},"uniParcId":"UPI000003F55F"}}