{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P03625","uniProtkbId":"G6P_BPPF3","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1986-07-21","entryVersion":73,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Pseudomonas phage Pf3","commonName":"Bacteriophage Pf3","taxonId":10872,"lineage":["Viruses","Floreoviria","Loebvirae","Hofneiviricota","Faserviricetes","Tubulavirales","Inoviridae","Tertilicivirus","Tertilicivirus Pf3"]},"organismHosts":[{"scientificName":"Pseudomonas aeruginosa","taxonId":287}],"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Head virion protein G6P"}},"alternativeNames":[{"fullName":{"value":"Coat protein D"}},{"fullName":{"value":"G6P"}},{"fullName":{"value":"pVI"}}]},"genes":[{"geneName":{"value":"VI"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Plays essential roles both in the entry of the viral genome into the bacterial host and in budding process. The formation of the G3P-G6P complex termed adsorption complex is essential for correct termination of filamentous phage assembly (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P69531"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P69532"}],"value":"Homopentamer (By similarity). Interacts with G3P; this interaction allows integration of G3P and G6P into the virion pointy tip. Interacts with capsid protein G8P; this interaction forms the G3P/G6P pointy tip of the virion (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P69532"}],"value":"Prior to assembly, G6P is found associated with the bacterial host inner membrane. There are about five copies of G6P in the mature virion. They are located together with G3P at the head side of the filamentous virion"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P69532"}],"value":"Virion","id":"SL-0274"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P69532"}],"value":"Host membrane","id":"SL-0380"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P69532"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the inovirus G6P protein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Head virion protein G6P","featureId":"PRO_0000098214"},{"type":"Transmembrane","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-1043","category":"Cellular component","name":"Host membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-1162","category":"Biological process","name":"Viral penetration into host cytoplasm"},{"id":"KW-1241","category":"Biological process","name":"Viral penetration into host cytoplasm via pilus retraction"},{"id":"KW-0946","category":"Cellular component","name":"Virion"},{"id":"KW-1160","category":"Biological process","name":"Virus entry into host cell"}],"references":[{"referenceNumber":1,"citation":{"id":"3928901","citationType":"journal article","authors":["Luiten R.G.M.","Putterman D.G.","Schoenmakers J.G.G.","Konings R.N.H.","Day L.A."],"citationCrossReferences":[{"database":"PubMed","id":"3928901"},{"database":"DOI","id":"10.1128/jvi.56.1.268-276.1985"}],"title":"Nucleotide sequence of the genome of Pf3, an IncP-1 plasmid-specific filamentous bacteriophage of Pseudomonas aeruginosa.","publicationDate":"1985","journal":"J. Virol.","firstPage":"268","lastPage":"276","volume":"56"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"New York","type":"STRAIN"},{"value":"Nijmegen","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M19377","properties":[{"key":"ProteinId","value":"AAA88389.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M11912","properties":[{"key":"ProteinId","value":"AAA88380.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A04233","properties":[{"key":"EntryName","value":"Z9BP33"}]},{"database":"RefSeq","id":"NP_040654.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001418.1"}]},{"database":"RefSeq","id":"YP_010774591.1","properties":[{"key":"NucleotideSequenceId","value":"NC_074763.1"}]},{"database":"GeneID","id":"1260907","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"80510901","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"vg:1260907","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001719","properties":[{"key":"Component","value":"Segment"}]},{"database":"Proteomes","id":"UP000009090","properties":[{"key":"Component","value":"Segment"}]},{"database":"GO","id":"GO:0033644","properties":[{"key":"GoTerm","value":"C:host cell membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0039666","properties":[{"key":"GoTerm","value":"P:virion attachment to host cell pilus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"InterPro","id":"IPR019670","properties":[{"key":"EntryName","value":"DUF2523"}]},{"database":"Pfam","id":"PF10734","properties":[{"key":"EntryName","value":"DUF2523"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARLLALVIGYALSSFVLKLFTVLGVGIFTYVGLTALVDGFLNLLQPMLTGLPSYILDILAIAGVPEALSIVGSALLTRASINSAKAFVGVLT","length":93,"molWeight":9640,"crc64":"757A1C8FE2204F60","md5":"46B7970786990B254F86491EB1F0413A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":2},"uniParcId":"UPI0000138636"}}