{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P02818","secondaryAccessions":["Q5TCK6"],"uniProtkbId":"OSTCN_HUMAN","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-08-01","entryVersion":205,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Osteocalcin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2336375"}],"value":"Bone Gla protein"},"shortNames":[{"value":"BGP"}]},{"fullName":{"value":"Gamma-carboxyglutamic acid-containing protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"BGLAP"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P86546"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3019668"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39880952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6967872"}],"value":"The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (PubMed:3019668, PubMed:6967872). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (By similarity). Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (PubMed:6967872, PubMed:39880952)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P86546"}],"value":"The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P02818","intActId":"EBI-12927282"},"interactantTwo":{"uniProtKBAccession":"Q12797-6","geneName":"ASPH","intActId":"EBI-12092171"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6967872"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P86546"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39880952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6967872"}],"value":"Carboxylated by vitamin K-dependent GGCX to form gamma-carboxyglutamate; these residues are essential for the binding of calcium (PubMed:6967872, PubMed:39880952). Decarboxylation promotes the hormone activity (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the osteocalcin/matrix Gla protein family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Osteocalcin","ftp":false,"note":"Osteocalcin entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Propeptide","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"6967872"}],"featureId":"PRO_0000011086"},{"type":"Chain","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Osteocalcin","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6967872"}],"featureId":"PRO_0000011087"},{"type":"Domain","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Gla","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00463"}]},{"type":"Binding site","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02820"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02820"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02820"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02820"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02820"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Site","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Not hydroxylated","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6967872"}]},{"type":"Modified residue","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"4-carboxyglutamate; partial","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6967872"}]},{"type":"Modified residue","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"4-carboxyglutamate","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6967872"}]},{"type":"Modified residue","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"4-carboxyglutamate","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6967872"}]},{"type":"Disulfide bond","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"6967872"}]},{"type":"Natural variant","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in dbSNP:rs34702397","featureCrossReferences":[{"database":"dbSNP","id":"rs34702397"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_038743","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"in Ref. 1; CAA27763","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}},{"type":"Beta strand","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BUX"}]},{"type":"Turn","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BUR"}]},{"type":"Beta strand","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BUR"}]},{"type":"Helix","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BUR"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0091","category":"Biological process","name":"Biomineralization"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0301","category":"PTM","name":"Gamma-carboxyglutamic acid"},{"id":"KW-0372","category":"Molecular function","name":"Hormone"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"3019668","citationType":"journal article","authors":["Celeste A.J.","Buecker J.L.","Kriz R.","Wang E.A.","Wozney J.M."],"citationCrossReferences":[{"database":"PubMed","id":"3019668"},{"database":"DOI","id":"10.1002/j.1460-2075.1986.tb04440.x"}],"title":"Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones.","publicationDate":"1986","journal":"EMBO J.","firstPage":"1885","lastPage":"1890","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","FUNCTION"]},{"referenceNumber":2,"citation":{"id":"2336375","citationType":"journal article","authors":["Kiefer M.C.","Saphire A.C.S.","Bauer D.M.","Barr P.J."],"citationCrossReferences":[{"database":"PubMed","id":"2336375"},{"database":"DOI","id":"10.1093/nar/18.7.1909"}],"title":"The cDNA and derived amino acid sequences of human and bovine bone Gla protein.","publicationDate":"1990","journal":"Nucleic Acids Res.","firstPage":"1909","lastPage":"1909","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"CI-DG51TBV8IRHEH","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT GLN-94"]},{"referenceNumber":4,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":7,"citation":{"id":"6967872","citationType":"journal article","authors":["Poser J.W.","Esch F.S.","Ling N.C.","Price P.A."],"citationCrossReferences":[{"database":"PubMed","id":"6967872"},{"database":"DOI","id":"10.1016/s0021-9258(18)43554-5"}],"title":"Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue.","publicationDate":"1980","journal":"J. Biol. Chem.","firstPage":"8685","lastPage":"8691","volume":"255"},"referencePositions":["PROTEIN SEQUENCE OF 52-100","FUNCTION","SUBCELLULAR LOCATION","GAMMA-CARBOXYGLUTAMATION AT GLU-68; GLU-72 AND GLU-75","LACK OF HYDROXYLATION AT PRO-60"]},{"referenceNumber":8,"citation":{"id":"39880952","citationType":"journal article","authors":["Wang R.","Chen B.","Elghobashi-Meinhardt N.","Tie J.K.","Ayala A.","Zhou N.","Qi X."],"citationCrossReferences":[{"database":"PubMed","id":"39880952"},{"database":"DOI","id":"10.1038/s41586-024-08484-9"}],"title":"Structure and mechanism of vitamin-K-dependent gamma-glutamyl carboxylase.","publicationDate":"2025","journal":"Nature","firstPage":"808","lastPage":"815","volume":"639"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.95 ANGSTROMS) IN COMPLEXES WITH VITAMIN K HYDROQUINONE; CHOLESTEROL AND GGCX","FUNCTION","CARBOXYLATION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"9BUR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"9BUX"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X04143","properties":[{"key":"ProteinId","value":"CAA27763.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X53698","properties":[{"key":"ProteinId","value":"CAA37736.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X51699","properties":[{"key":"ProteinId","value":"CAA35996.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ007079","properties":[{"key":"ProteinId","value":"AAY16981.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL135927","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471121","properties":[{"key":"ProteinId","value":"EAW52986.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC113432","properties":[{"key":"ProteinId","value":"AAI13433.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC113434","properties":[{"key":"ProteinId","value":"AAI13435.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1134.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S12652","properties":[{"key":"EntryName","value":"GEHU"}]},{"database":"RefSeq","id":"NP_954642.1","properties":[{"key":"NucleotideSequenceId","value":"NM_199173.6"}]},{"database":"PDB","id":"8XS1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=94-100"}]},{"database":"PDB","id":"9BUR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"B=1-100"}]},{"database":"PDB","id":"9BUX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.06 A"},{"key":"Chains","value":"B=1-100"}]},{"database":"PDB","id":"9L23","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.62 A"},{"key":"Chains","value":"B=33-100"}]},{"database":"PDB","id":"9MQB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.37 A"},{"key":"Chains","value":"P=1-100"}]},{"database":"PDB","id":"9MQC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.13 A"},{"key":"Chains","value":"P=1-100"}]},{"database":"PDB","id":"9MQE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.56 A"},{"key":"Chains","value":"P=1-100"}]},{"database":"PDB","id":"9WF2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.94 A"},{"key":"Chains","value":"B=33-100"}]},{"database":"PDBsum","id":"8XS1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BUR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BUX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9L23","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MQB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MQC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MQE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9WF2","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P02818","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44917","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44924","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48519","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48520","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48522","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62767","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-65921","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P02818","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107101","properties":[{"key":"Interactions","value":"16"}]},{"database":"FunCoup","id":"P02818","properties":[{"key":"Number of interactors","value":"113"}]},{"database":"IntAct","id":"P02818","properties":[{"key":"Interactions","value":"6"}]},{"database":"NDEx","id":"IQUERY-CP-BGLAP","properties":[{"key":"Evidences","value":"10 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000357255","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB03847","properties":[{"key":"GenericName","value":"gamma-carboxy-L-glutamic acid"}]},{"database":"DrugBank","id":"DB00170","properties":[{"key":"GenericName","value":"Menadione"}]},{"database":"DrugBank","id":"DB01022","properties":[{"key":"GenericName","value":"Phylloquinone"}]},{"database":"BioMuta","id":"BGLAP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"129253","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P02818","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000357255","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P02818","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51606","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P02818","properties":[{"key":"antibodies","value":"5 sequenced antibodies"}]},{"database":"Antibodypedia","id":"34848","properties":[{"key":"antibodies","value":"1008 antibodies from 45 providers"}]},{"database":"DNASU","id":"632","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000368272.5","properties":[{"key":"ProteinId","value":"ENSP00000357255.4"},{"key":"GeneId","value":"ENSG00000242252.2"}]},{"database":"GeneID","id":"632","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:632","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000368272.5","properties":[{"key":"ProteinId","value":"ENSP00000357255.4"},{"key":"RefSeqNucleotideId","value":"NM_199173.6"},{"key":"RefSeqProteinId","value":"NP_954642.1"}]},{"database":"UCSC","id":"uc001fnt.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:1043","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA25345","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"632","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"632","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"BGLAP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1043","properties":[{"key":"GeneName","value":"BGLAP"}]},{"database":"HPA","id":"ENSG00000242252","properties":[{"key":"ExpressionPatterns","value":"Group enriched (brain, choroid plexus, intestine)"}]},{"database":"MIM","id":"112260","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000242252","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000242252","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S85I","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00410000026290","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_160110_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P02818","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MDTEGII","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9950568at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P02818","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P02818","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P02818","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-159740","properties":[{"key":"PathwayName","value":"Gamma-carboxylation of protein precursors"}]},{"database":"Reactome","id":"R-HSA-159763","properties":[{"key":"PathwayName","value":"Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"}]},{"database":"Reactome","id":"R-HSA-159782","properties":[{"key":"PathwayName","value":"Removal of aminoterminal propeptides from gamma-carboxylated proteins"}]},{"database":"Reactome","id":"R-HSA-8940973","properties":[{"key":"PathwayName","value":"RUNX2 regulates osteoblast differentiation"}]},{"database":"SignaLink","id":"P02818","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P02818","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000242252","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"632","properties":[{"key":"hits","value":"22 hits in 1149 CRISPR screens"}]},{"database":"GeneWiki","id":"Osteocalcin","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"632","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P02818","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P02818","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"P02818","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000242252","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 94 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11856645"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005788","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6967872"}]},{"database":"GO","id":"GO:0005796","properties":[{"key":"GoTerm","value":"C:Golgi lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0140144","properties":[{"key":"GoTerm","value":"C:non-collagenous component of basement membrane"},{"key":"GoEvidenceType","value":"TAS:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"36399478"}]},{"database":"GO","id":"GO:0043204","properties":[{"key":"GoTerm","value":"C:perikaryon"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031982","properties":[{"key":"GoTerm","value":"C:vesicle"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005179","properties":[{"key":"GoTerm","value":"F:hormone activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046848","properties":[{"key":"GoTerm","value":"F:hydroxyapatite binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008147","properties":[{"key":"GoTerm","value":"F:structural constituent of bone"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"NAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10486212"}]},{"database":"GO","id":"GO:0060348","properties":[{"key":"GoTerm","value":"P:bone development"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030282","properties":[{"key":"GoTerm","value":"P:bone mineralization"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10486212"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12202187"}]},{"database":"GO","id":"GO:0071363","properties":[{"key":"GoTerm","value":"P:cellular response to growth factor stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032869","properties":[{"key":"GoTerm","value":"P:cellular response to insulin stimulus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071305","properties":[{"key":"GoTerm","value":"P:cellular response to vitamin D"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034224","properties":[{"key":"GoTerm","value":"P:cellular response to zinc ion starvation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050890","properties":[{"key":"GoTerm","value":"P:cognition"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042593","properties":[{"key":"GoTerm","value":"P:glucose homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1903011","properties":[{"key":"GoTerm","value":"P:negative regulation of bone development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001649","properties":[{"key":"GoTerm","value":"P:osteoblast differentiation"},{"key":"GoEvidenceType","value":"IEP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"17023519"}]},{"database":"GO","id":"GO:0001956","properties":[{"key":"GoTerm","value":"P:positive regulation of neurotransmitter secretion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030500","properties":[{"key":"GoTerm","value":"P:regulation of bone mineralization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045124","properties":[{"key":"GoTerm","value":"P:regulation of bone resorption"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10486212"}]},{"database":"GO","id":"GO:1900076","properties":[{"key":"GoTerm","value":"P:regulation of cellular response to insulin stimulus"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045670","properties":[{"key":"GoTerm","value":"P:regulation of osteoclast differentiation"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10486212"}]},{"database":"GO","id":"GO:2000224","properties":[{"key":"GoTerm","value":"P:regulation of testosterone biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0014823","properties":[{"key":"GoTerm","value":"P:response to activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043627","properties":[{"key":"GoTerm","value":"P:response to estrogen"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045471","properties":[{"key":"GoTerm","value":"P:response to ethanol"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051384","properties":[{"key":"GoTerm","value":"P:response to glucocorticoid"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009629","properties":[{"key":"GoTerm","value":"P:response to gravity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0033594","properties":[{"key":"GoTerm","value":"P:response to hydroxyisoflavone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0036005","properties":[{"key":"GoTerm","value":"P:response to macrophage colony-stimulating factor"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009612","properties":[{"key":"GoTerm","value":"P:response to mechanical stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0033574","properties":[{"key":"GoTerm","value":"P:response to testosterone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0033280","properties":[{"key":"GoTerm","value":"P:response to vitamin D"},{"key":"GoEvidenceType","value":"IEP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"17023519"}]},{"database":"GO","id":"GO:0032571","properties":[{"key":"GoTerm","value":"P:response to vitamin K"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009410","properties":[{"key":"GoTerm","value":"P:response to xenobiotic stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0010043","properties":[{"key":"GoTerm","value":"P:response to zinc ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001501","properties":[{"key":"GoTerm","value":"P:skeletal system development"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10865224"}]},{"database":"GO","id":"GO:0048863","properties":[{"key":"GoTerm","value":"P:stem cell differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044342","properties":[{"key":"GoTerm","value":"P:type B pancreatic cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR058704","properties":[{"key":"EntryName","value":"BGLAP-like_C"}]},{"database":"InterPro","id":"IPR035972","properties":[{"key":"EntryName","value":"GLA-like_dom_SF"}]},{"database":"InterPro","id":"IPR000294","properties":[{"key":"EntryName","value":"GLA_domain"}]},{"database":"InterPro","id":"IPR039176","properties":[{"key":"EntryName","value":"Osteocalcin"}]},{"database":"InterPro","id":"IPR002384","properties":[{"key":"EntryName","value":"Osteocalcin/MGP"}]},{"database":"PANTHER","id":"PTHR14235","properties":[{"key":"EntryName","value":"OSTEOCALCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14235:SF0","properties":[{"key":"EntryName","value":"OSTEOCALCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25890","properties":[{"key":"EntryName","value":"BGLAP_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00002","properties":[{"key":"EntryName","value":"GLABONE"}]},{"database":"SMART","id":"SM00069","properties":[{"key":"EntryName","value":"GLA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57630","properties":[{"key":"EntryName","value":"GLA-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00011","properties":[{"key":"EntryName","value":"GLA_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50998","properties":[{"key":"EntryName","value":"GLA_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV","length":100,"molWeight":10963,"crc64":"4DF2A0A80849CB71","md5":"8F384D42D476FA253BD70D46934607E9"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"PTM":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Domain":1,"Binding site":5,"Site":1,"Modified residue":3,"Disulfide bond":1,"Natural variant":1,"Sequence conflict":1,"Beta strand":2,"Turn":1,"Helix":1},"uniParcId":"UPI0000130EDF"}}