{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P01375","secondaryAccessions":["O43647","Q9P1Q2","Q9UIV3"],"uniProtkbId":"TNFA_HUMAN","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1986-07-21","entryVersion":283,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Tumor necrosis factor"}},"alternativeNames":[{"fullName":{"value":"Cachectin"}},{"fullName":{"value":"TNF-alpha"}},{"fullName":{"value":"Tumor necrosis factor ligand superfamily member 2"},"shortNames":[{"value":"TNF-a"}]}],"contains":[{"recommendedName":{"fullName":{"value":"Tumor necrosis factor, membrane form"}},"alternativeNames":[{"fullName":{"value":"N-terminal fragment"},"shortNames":[{"value":"NTF"}]}]},{"recommendedName":{"fullName":{"value":"Intracellular domain 1"},"shortNames":[{"value":"ICD1"}]}},{"recommendedName":{"fullName":{"value":"Intracellular domain 2"},"shortNames":[{"value":"ICD2"}]}},{"recommendedName":{"fullName":{"value":"C-domain 1"}}},{"recommendedName":{"fullName":{"value":"C-domain 2"}}},{"recommendedName":{"fullName":{"value":"Tumor necrosis factor, soluble form"}}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"TNF"},"synonyms":[{"value":"TNFA"},{"value":"TNFSF2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P06804"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12794819"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22517918"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23396208"}],"value":"Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:16829952, PubMed:22517918, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829952"}],"value":"The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829951"}],"value":"Homotrimer. Interacts with SPPL2B"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q92482","geneName":"AQP3","intActId":"EBI-2808854"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q9BXK5","geneName":"BCL2L13","intActId":"EBI-747430"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q6UXG8-3","geneName":"BTNL9","intActId":"EBI-17953245"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q8IYJ2-2","geneName":"C10orf67","intActId":"EBI-13381098"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q8WV48","geneName":"CCDC107","intActId":"EBI-947033"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q6NSX1","geneName":"CCDC70","intActId":"EBI-6873045"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"O95471","geneName":"CLDN7","intActId":"EBI-740744"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q8IUN9","geneName":"CLEC10A","intActId":"EBI-2873246"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q96BA8","geneName":"CREB3L1","intActId":"EBI-6942903"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"P00387","geneName":"CYB5R3","intActId":"EBI-1046040"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q5JX71","geneName":"FAM209A","intActId":"EBI-18304435"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"O15552","geneName":"FFAR2","intActId":"EBI-2833872"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q8TBE3","geneName":"FNDC9","intActId":"EBI-12142257"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q9Y6K9","geneName":"IKBKG","intActId":"EBI-81279"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q8N6L0","geneName":"KASH5","intActId":"EBI-749265"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q8N386","geneName":"LRRC25","intActId":"EBI-11304917"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"O43300","geneName":"LRRTM2","intActId":"EBI-18096461"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q9HC36","geneName":"MRM3","intActId":"EBI-1045440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"O75459","geneName":"PAGE1","intActId":"EBI-2559100"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q96RD7","geneName":"PANX1","intActId":"EBI-7037612"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q8N4L2","geneName":"PIP4P2","intActId":"EBI-2820617"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q53GL0","geneName":"PLEKHO1","intActId":"EBI-949945"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q6ZMZ0","geneName":"RNF19B","intActId":"EBI-2466594"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"P31949","geneName":"S100A11","intActId":"EBI-701862"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"P80511","geneName":"S100A12","intActId":"EBI-2823305"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q99584","geneName":"S100A13","intActId":"EBI-721909"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q16585","geneName":"SGCB","intActId":"EBI-5663627"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q15849","geneName":"SLC14A2","intActId":"EBI-1573290"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"O14863","geneName":"SLC30A4","intActId":"EBI-13918058"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q8WWF3","geneName":"SSMEM1","intActId":"EBI-17280858"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"P27105","geneName":"STOM","intActId":"EBI-1211440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q16623","geneName":"STX1A","intActId":"EBI-712466"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"O15393-2","geneName":"TMPRSS2","intActId":"EBI-12345267"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"P01375","geneName":"TNF","intActId":"EBI-359977"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"P19438","geneName":"TNFRSF1A","intActId":"EBI-299451"},"numberOfExperiments":32,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"P20333","geneName":"TNFRSF1B","intActId":"EBI-358983"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q9H7M9","geneName":"VSIR","intActId":"EBI-744988"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q96S55","geneName":"WRNIP1","intActId":"EBI-2513471"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q6PEW1","geneName":"ZCCHC12","intActId":"EBI-748373"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q9DHW0","geneName":"2L","intActId":"EBI-15810797"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"O89110","geneName":"Casp8","intActId":"EBI-851690"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q8UYL3","geneName":"crmE","intActId":"EBI-7539950"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"O88351","geneName":"Ikbkb","intActId":"EBI-447960"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q60855","geneName":"Ripk1","intActId":"EBI-529119"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q60769","geneName":"Tnfaip3","intActId":"EBI-646595"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"P25118","geneName":"Tnfrsf1a","intActId":"EBI-518014"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P01375","intActId":"EBI-359977"},"interactantTwo":{"uniProtKBAccession":"Q3U0V2","geneName":"Tradd","intActId":"EBI-1544032"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829952"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829952"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Tumor necrosis factor, membrane form","subcellularLocations":[{"location":{"value":"Membrane","id":"SL-0162"},"topology":{"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Tumor necrosis factor, soluble form","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23552949"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"C-domain 1","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"C-domain 2","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9034191"}],"value":"The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10205166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8597870"}],"value":"The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8631363"}],"value":"O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23552949"}],"value":"The soluble form is demyristoylated at Lys-19 and Lys-20 by SIRT6, promoting its secretion"}],"commentType":"PTM","molecule":"Tumor necrosis factor, soluble form"},{"texts":[{"value":"Genetic variations in TNF influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]"}],"commentType":"POLYMORPHISM"},{"texts":[{"value":"Genetic variations in TNF are involved in susceptibility to malaria [MIM:611162]"}],"commentType":"POLYMORPHISM"},{"commentType":"DISEASE","disease":{"diseaseId":"Psoriatic arthritis","diseaseAccession":"DI-02697","acronym":"PSORAS","description":"An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).","diseaseCrossReference":{"database":"MIM","id":"607507"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12746914"}]},"note":{"texts":[{"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Immunodeficiency 127","diseaseAccession":"DI-06955","acronym":"IMD127","description":"An autosomal recessive immunologic disorder characterized by increased susceptibility to pulmonary infection with Mycobacterium tuberculosis. Affected individuals develop recurrent pulmonary tuberculosis, but have no adverse reaction to live BCG vaccination.","diseaseCrossReference":{"database":"MIM","id":"620977"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39198650"}]},"note":{"texts":[{"value":"The disease may be caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the tumor necrosis factor family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAF71992.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"CAA75070.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Tumor_necrosis_factor-alpha","ftp":false,"note":"Tumor necrosis factor alpha entry"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/319/TNFa","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Tumor necrosis factor, membrane form","featureId":"PRO_0000034423"},{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Intracellular domain 1","featureId":"PRO_0000417231"},{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Intracellular domain 2","featureId":"PRO_0000417232"},{"type":"Chain","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":null,"modifier":"UNKNOWN"}},"description":"C-domain 1","featureId":"PRO_0000417233"},{"type":"Chain","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":null,"modifier":"UNKNOWN"}},"description":"C-domain 2","featureId":"PRO_0000417234"},{"type":"Chain","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Tumor necrosis factor, soluble form","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3856324"}],"featureId":"PRO_0000034424"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"THD","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01387"}]},{"type":"Site","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Cleavage; by SPPL2A or SPPL2B"},{"type":"Site","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Cleavage; by SPPL2A or SPPL2B"},{"type":"Site","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Cleavage; by SPPL2A or SPPL2B"},{"type":"Site","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Cleavage; by SPPL2A or SPPL2B"},{"type":"Site","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Cleavage; by ADAM17"},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"Phosphoserine; by CK1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Lipidation","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"N6-myristoyl lysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1402651"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23552949"}]},{"type":"Lipidation","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"N6-myristoyl lysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1402651"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23552949"}]},{"type":"Glycosylation","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine; in soluble form","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8631363"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01387"}]},{"type":"Natural variant","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"in dbSNP:rs4645843","featureCrossReferences":[{"database":"dbSNP","id":"rs4645843"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.13"}],"featureId":"VAR_019378","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in dbSNP:rs1800620","featureCrossReferences":[{"database":"dbSNP","id":"rs1800620"}],"featureId":"VAR_011927","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Abolished myristoylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23552949"}],"alternativeSequence":{"originalSequence":"KK","alternativeSequences":["RR"]}},{"type":"Mutagenesis","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Low activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2009860"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Biologically inactive.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2009860"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Mutagenesis","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Biologically inactive.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2009860"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Biologically inactive.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2009860"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"Biologically inactive.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2009860"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Biologically inactive.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2009860"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A","D"]}},{"type":"Mutagenesis","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Biologically inactive.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2009860"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"in Ref. 5; AAA61198","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"in Ref. 17; AAF71992","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"PSD","alternativeSequences":["VNR"]}},{"type":"Sequence conflict","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"in Ref. 16; AAC03542","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ASY"}]},{"type":"Helix","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ASY"}]},{"type":"Helix","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JRA"}]},{"type":"Beta strand","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Beta strand","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5M2I"}]},{"type":"Beta strand","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2E7A"}]},{"type":"Beta strand","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Beta strand","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Beta strand","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Beta strand","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Beta strand","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2ZPX"}]},{"type":"Beta strand","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Beta strand","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Beta strand","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1A8M"}]},{"type":"Helix","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2E7A"}]},{"type":"Beta strand","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1A8M"}]},{"type":"Helix","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X86"}]},{"type":"Beta strand","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Beta strand","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Helix","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]},{"type":"Turn","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7TA6"}]},{"type":"Beta strand","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OJO"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0519","category":"PTM","name":"Myristate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"3555974","citationType":"journal article","authors":["Nedospasov S.A.","Shakhov A.N.","Turetskaya R.L.","Mett V.A.","Azizov M.M.","Georgiev G.P.","Korobko V.G.","Dobrynin V.N.","Filippov S.A.","Bystrov N.S.","Boldyreva E.F.","Chuvpilo S.A.","Chumakov A.M.","Shingarova L.N.","Ovchinnikov Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"3555974"},{"database":"DOI","id":"10.1101/sqb.1986.051.01.073"}],"title":"Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome.","publicationDate":"1986","journal":"Cold Spring Harb. Symp. Quant. Biol.","firstPage":"611","lastPage":"624","volume":"51"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"6392892","citationType":"journal article","authors":["Pennica D.","Nedwin G.E.","Hayflick J.S.","Seeburg P.H.","Derynck R.","Palladino M.A.","Kohr W.J.","Aggarwal B.B.","Goeddel D.V."],"citationCrossReferences":[{"database":"PubMed","id":"6392892"},{"database":"DOI","id":"10.1038/312724a0"}],"title":"Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.","publicationDate":"1984","journal":"Nature","firstPage":"724","lastPage":"729","volume":"312"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]"]},{"referenceNumber":3,"citation":{"id":"3883195","citationType":"journal article","authors":["Shirai T.","Yamaguchi H.","Ito H.","Todd C.W.","Wallace R.B."],"citationCrossReferences":[{"database":"PubMed","id":"3883195"},{"database":"DOI","id":"10.1038/313803a0"}],"title":"Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.","publicationDate":"1985","journal":"Nature","firstPage":"803","lastPage":"806","volume":"313"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]"]},{"referenceNumber":4,"citation":{"id":"2995927","citationType":"journal article","authors":["Nedwin G.E.","Naylor S.L.","Sakaguchi A.Y.","Smith D.H.","Jarrett-Nedwin J.","Pennica D.","Goeddel D.V.","Gray P.W."],"citationCrossReferences":[{"database":"PubMed","id":"2995927"},{"database":"DOI","id":"10.1093/nar/13.17.6361"}],"title":"Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.","publicationDate":"1985","journal":"Nucleic Acids Res.","firstPage":"6361","lastPage":"6373","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]"]},{"referenceNumber":5,"citation":{"id":"3856324","citationType":"journal article","authors":["Wang A.M.","Creasey A.A.","Ladner M.B.","Lin L.S.","Strickler J.","van Arsdell J.N.","Yamamoto R.","Mark D.F."],"citationCrossReferences":[{"database":"PubMed","id":"3856324"},{"database":"DOI","id":"10.1126/science.3856324"}],"title":"Molecular cloning of the complementary DNA for human tumor necrosis factor.","publicationDate":"1985","journal":"Science","firstPage":"149","lastPage":"154","volume":"228"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":6,"citation":{"id":"3932069","citationType":"journal article","authors":["Marmenout A.","Fransen L.","Tavernier J.","van der Heyden J.","Tizard R.","Kawashima E.","Shaw A.","Johnson M.J.","Semon D.","Mueller R.","Ruysschaert M.-R.","van Vliet A.","Fiers W."],"citationCrossReferences":[{"database":"PubMed","id":"3932069"},{"database":"DOI","id":"10.1111/j.1432-1033.1985.tb09226.x"}],"title":"Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor.","publicationDate":"1985","journal":"Eur. J. Biochem.","firstPage":"515","lastPage":"522","volume":"152"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"8499947","citationType":"journal article","authors":["Iris F.J.M.","Bougueleret L.","Prieur S.","Caterina D.","Primas G.","Perrot V.","Jurka J.","Rodriguez-Tome P.","Claverie J.-M.","Dausset J.","Cohen D."],"citationCrossReferences":[{"database":"PubMed","id":"8499947"},{"database":"DOI","id":"10.1038/ng0293-137"}],"title":"Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.","publicationDate":"1993","journal":"Nat. Genet.","firstPage":"137","lastPage":"145","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"10202016","citationType":"journal article","authors":["Neville M.J.","Campbell R.D."],"citationCrossReferences":[{"database":"PubMed","id":"10202016"}],"title":"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.","publicationDate":"1999","journal":"J. Immunol.","firstPage":"4745","lastPage":"4754","volume":"162"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"14656967","citationType":"journal article","authors":["Xie T.","Rowen L.","Aguado B.","Ahearn M.E.","Madan A.","Qin S.","Campbell R.D.","Hood L."],"citationCrossReferences":[{"database":"PubMed","id":"14656967"},{"database":"DOI","id":"10.1101/gr.1736803"}],"title":"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2621","lastPage":"2636","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":10,"citation":{"id":"CI-C28MMRF9FQI79","citationType":"submission","authors":["Shiina S.","Tamiya G.","Oka A.","Inoko H."],"title":"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.","publicationDate":"SEP-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":11,"citation":{"id":"CI-6Q9SLGBFNCTQL","citationType":"submission","authors":["Shiina T.","Ota M.","Katsuyama Y.","Hashimoto N.","Inoko H."],"title":"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions.","publicationDate":"JUL-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":12,"citation":{"id":"CI-6O5191F0NKAFQ","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"DEC-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":13,"citation":{"id":"CI-9GAL9GH7V57OH","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"JAN-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT LEU-84"]},{"referenceNumber":14,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"8631363","citationType":"journal article","authors":["Takakura-Yamamoto R.","Yamamoto S.","Fukuda S.","Kurimoto M."],"citationCrossReferences":[{"database":"PubMed","id":"8631363"},{"database":"DOI","id":"10.1111/j.1432-1033.1996.00431.x"}],"title":"O-glycosylated species of natural human tumor-necrosis factor-alpha.","publicationDate":"1996","journal":"Eur. J. Biochem.","firstPage":"431","lastPage":"437","volume":"235"},"referencePositions":["PROTEIN SEQUENCE OF 77-99","GLYCOSYLATION AT SER-80"]},{"referenceNumber":16,"citation":{"id":"CI-AJPBNPU5F8GVS","citationType":"submission","authors":["Jang J.S.","Kim B.E."],"publicationDate":"JAN-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 77-233"]},{"referenceNumber":17,"citation":{"id":"CI-7CADKLH2MV4V8","citationType":"submission","authors":["Shao C.","Yan W.","Zhu F.","Yue W.","Chai Y.","Zhao Z.","Wang C."],"publicationDate":"MAR-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 84-214"],"referenceComments":[{"value":"Prostatic carcinoma","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"8597870","citationType":"journal article","authors":["Pocsik E.","Duda E.","Wallach D."],"citationCrossReferences":[{"database":"PubMed","id":"8597870"}],"title":"Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells.","publicationDate":"1995","journal":"J. Inflamm.","firstPage":"152","lastPage":"160","volume":"45"},"referencePositions":["PHOSPHORYLATION (MEMBRANE FORM)"]},{"referenceNumber":19,"citation":{"id":"10205166","citationType":"journal article","authors":["Watts A.D.","Hunt N.H.","Wanigasekara Y.","Bloomfield G.","Wallach D.","Roufogalis B.D.","Chaudhri G."],"citationCrossReferences":[{"database":"PubMed","id":"10205166"},{"database":"DOI","id":"10.1093/emboj/18.8.2119"}],"title":"A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'.","publicationDate":"1999","journal":"EMBO J.","firstPage":"2119","lastPage":"2126","volume":"18"},"referencePositions":["PHOSPHORYLATION BY CK1","DEPHOSPHORYLATION"]},{"referenceNumber":20,"citation":{"id":"2009860","citationType":"journal article","authors":["Ostade X.V.","Tavernier J.","Prange T.","Fiers W."],"citationCrossReferences":[{"database":"PubMed","id":"2009860"},{"database":"DOI","id":"10.1002/j.1460-2075.1991.tb08015.x"}],"title":"Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis.","publicationDate":"1991","journal":"EMBO J.","firstPage":"827","lastPage":"836","volume":"10"},"referencePositions":["MUTAGENESIS"]},{"referenceNumber":21,"citation":{"id":"1402651","citationType":"journal article","authors":["Stevenson F.T.","Bursten S.L.","Locksley R.M.","Lovett D.H."],"citationCrossReferences":[{"database":"PubMed","id":"1402651"},{"database":"DOI","id":"10.1084/jem.176.4.1053"}],"title":"Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.","publicationDate":"1992","journal":"J. Exp. Med.","firstPage":"1053","lastPage":"1062","volume":"176"},"referencePositions":["MYRISTOYLATION AT LYS-19 AND LYS-20"]},{"referenceNumber":22,"citation":{"id":"9034191","citationType":"journal article","authors":["Moss M.L.","Jin S.-L.C.","Milla M.E.","Burkhart W.","Carter H.L.","Chen W.-J.","Clay W.C.","Didsbury J.R.","Hassler D.","Hoffman C.R.","Kost T.A.","Lambert M.H.","Leesnitzer M.A.","McCauley P.","McGeehan G.","Mitchell J.","Moyer M.","Pahel G.","Rocque W.","Overton L.K.","Schoenen F.","Seaton T.","Su J.-L.","Warner J.","Willard D.","Becherer J.D."],"citationCrossReferences":[{"database":"PubMed","id":"9034191"},{"database":"DOI","id":"10.1038/385733a0"}],"title":"Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.","publicationDate":"1997","journal":"Nature","firstPage":"733","lastPage":"736","volume":"385"},"referencePositions":["CLEAVAGE BY ADAM17"]},{"referenceNumber":23,"citation":{"id":"10369255","citationType":"journal article","authors":["Knight J.C.","Udalova I.","Hill A.V.","Greenwood B.M.","Peshu N.","Marsh K.","Kwiatkowski D."],"citationCrossReferences":[{"database":"PubMed","id":"10369255"},{"database":"DOI","id":"10.1038/9649"}],"title":"A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria.","publicationDate":"1999","journal":"Nat. Genet.","firstPage":"145","lastPage":"150","volume":"22"},"referencePositions":["POLYMORPHISM","INVOLVEMENT IN SUSCEPTIBILITY TO MALARIA"]},{"referenceNumber":24,"citation":{"id":"12746914","citationType":"journal article","authors":["Balding J.","Kane D.","Livingstone W.","Mynett-Johnson L.","Bresnihan B.","Smith O.","FitzGerald O."],"citationCrossReferences":[{"database":"PubMed","id":"12746914"},{"database":"DOI","id":"10.1002/art.10935"}],"title":"Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity.","publicationDate":"2003","journal":"Arthritis Rheum.","firstPage":"1408","lastPage":"1413","volume":"48"},"referencePositions":["INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY"]},{"referenceNumber":25,"citation":{"id":"12794819","citationType":"journal article","authors":["Nakahara H.","Song J.","Sugimoto M.","Hagihara K.","Kishimoto T.","Yoshizaki K.","Nishimoto N."],"citationCrossReferences":[{"database":"PubMed","id":"12794819"},{"database":"DOI","id":"10.1002/art.11143"}],"title":"Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.","publicationDate":"2003","journal":"Arthritis Rheum.","firstPage":"1521","lastPage":"1529","volume":"48"},"referencePositions":["FUNCTION"]},{"referenceNumber":26,"citation":{"id":"12915457","citationType":"journal article","authors":["Kim Y.J.","Lee H.-S.","Yoon J.-H.","Kim C.Y.","Park M.H.","Kim L.H.","Park B.L.","Shin H.D."],"citationCrossReferences":[{"database":"PubMed","id":"12915457"},{"database":"DOI","id":"10.1093/hmg/ddg262"}],"title":"Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection.","publicationDate":"2003","journal":"Hum. Mol. Genet.","firstPage":"2541","lastPage":"2546","volume":"12"},"referencePositions":["INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION"]},{"referenceNumber":27,"citation":{"id":"16829952","citationType":"journal article","authors":["Friedmann E.","Hauben E.","Maylandt K.","Schleeger S.","Vreugde S.","Lichtenthaler S.F.","Kuhn P.H.","Stauffer D.","Rovelli G.","Martoglio B."],"citationCrossReferences":[{"database":"PubMed","id":"16829952"},{"database":"DOI","id":"10.1038/ncb1440"}],"title":"SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.","publicationDate":"2006","journal":"Nat. Cell Biol.","firstPage":"843","lastPage":"848","volume":"8"},"referencePositions":["FUNCTION OF TNF INTRACELLULAR DOMAIN","CLEAVAGE BY SPPL2A AND SPPL2B","SUBCELLULAR LOCATION"]},{"referenceNumber":28,"citation":{"id":"16829951","citationType":"journal article","authors":["Fluhrer R.","Grammer G.","Israel L.","Condron M.M.","Haffner C.","Friedmann E.","Bohland C.","Imhof A.","Martoglio B.","Teplow D.B.","Haass C."],"citationCrossReferences":[{"database":"PubMed","id":"16829951"},{"database":"DOI","id":"10.1038/ncb1450"}],"title":"A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.","publicationDate":"2006","journal":"Nat. Cell Biol.","firstPage":"894","lastPage":"896","volume":"8"},"referencePositions":["CLEAVAGE BY SPPL2A AND SPPL2B","CLEAVAGE SITE","INTERACTION WITH SPPL2B","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":29,"citation":{"id":"22517918","citationType":"journal article","authors":["Jinesh G.G.","Chunduru S.","Kamat A.M."],"citationCrossReferences":[{"database":"PubMed","id":"22517918"},{"database":"DOI","id":"10.1189/jlb.1211623"}],"title":"Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-alpha but not through TRAIL and FasL.","publicationDate":"2012","journal":"J. Leukoc. Biol.","firstPage":"233","lastPage":"244","volume":"92"},"referencePositions":["FUNCTION"]},{"referenceNumber":30,"citation":{"id":"23552949","citationType":"journal article","authors":["Jiang H.","Khan S.","Wang Y.","Charron G.","He B.","Sebastian C.","Du J.","Kim R.","Ge E.","Mostoslavsky R.","Hang H.C.","Hao Q.","Lin H."],"citationCrossReferences":[{"database":"PubMed","id":"23552949"},{"database":"DOI","id":"10.1038/nature12038"}],"title":"SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine.","publicationDate":"2013","journal":"Nature","firstPage":"110","lastPage":"113","volume":"496"},"referencePositions":["MYRISTOYLATION AT LYS-19 AND LYS-20","DEMYRISTOYLATION AT LYS-19 AND LYS-20","SUBCELLULAR LOCATION (TUMOR NECROSIS FACTOR","SOLUBLE FORM)","MUTAGENESIS OF 19-LYS-LYS-20"]},{"referenceNumber":31,"citation":{"id":"23396208","citationType":"journal article","authors":["Nie H.","Zheng Y.","Li R.","Guo T.B.","He D.","Fang L.","Liu X.","Xiao L.","Chen X.","Wan B.","Chin Y.E.","Zhang J.Z."],"citationCrossReferences":[{"database":"PubMed","id":"23396208"},{"database":"DOI","id":"10.1038/nm.3085"}],"title":"Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis.","publicationDate":"2013","journal":"Nat. Med.","firstPage":"322","lastPage":"328","volume":"19"},"referencePositions":["FUNCTION"]},{"referenceNumber":32,"citation":{"id":"39198650","citationType":"journal article","authors":["Arias A.A.","Neehus A.L.","Ogishi M.","Meynier V.","Krebs A.","Lazarov T.","Lee A.M.","Arango-Franco C.A.","Yang R.","Orrego J.","Corcini Berndt M.","Rojas J.","Li H.","Rinchai D.","Erazo-Borras L.","Han J.E.","Pillay B.","Ponsin K.","Chaldebas M.","Philippot Q.","Bohlen J.","Rosain J.","Le Voyer T.","Janotte T.","Amarajeeva K.","Soudee C.","Brollo M.","Wiegmann K.","Marquant Q.","Seeleuthner Y.","Lee D.","Laine C.","Kloos D.","Bailey R.","Bastard P.","Keating N.","Rapaport F.","Khan T.","Moncada-Velez M.","Carmona M.C.","Obando C.","Alvarez J.","Catano J.C.","Martinez-Rosado L.L.","Sanchez J.P.","Tejada-Giraldo M.","L'Honneur A.S.","Agudelo M.L.","Perez-Zapata L.J.","Arboleda D.M.","Alzate J.F.","Cabarcas F.","Zuluaga A.","Pelham S.J.","Ensser A.","Schmidt M.","Velasquez-Lopera M.M.","Jouanguy E.","Puel A.","Kroenke M.","Ghirardello S.","Borghesi A.","Pahari S.","Boisson B.","Pittaluga S.","Ma C.S.","Emile J.F.","Notarangelo L.D.","Tangye S.G.","Marr N.","Lachmann N.","Salvator H.","Schlesinger L.S.","Zhang P.","Glickman M.S.","Nathan C.F.","Geissmann F.","Abel L.","Franco J.L.","Bustamante J.","Casanova J.L.","Boisson-Dupuis S."],"citationCrossReferences":[{"database":"PubMed","id":"39198650"},{"database":"DOI","id":"10.1038/s41586-024-07866-3"}],"title":"Tuberculosis in otherwise healthy adults with inherited TNF deficiency.","publicationDate":"2024","journal":"Nature","firstPage":"417","lastPage":"425","volume":"633"},"referencePositions":["INVOLVEMENT IN IMD127"]},{"referenceNumber":33,"citation":{"id":"2922050","citationType":"journal article","authors":["Jones E.Y.","Stuart D.I.","Walker N.P."],"citationCrossReferences":[{"database":"PubMed","id":"2922050"},{"database":"DOI","id":"10.1038/338225a0"}],"title":"Structure of tumour necrosis factor.","publicationDate":"1989","journal":"Nature","firstPage":"225","lastPage":"228","volume":"338"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS)"]},{"referenceNumber":34,"citation":{"id":"1964681","citationType":"journal article","authors":["Jones E.Y.","Stuart D.I.","Walker N.P."],"citationCrossReferences":[{"database":"PubMed","id":"1964681"},{"database":"DOI","id":"10.1242/jcs.1990.supplement_13.3"}],"title":"The structure of tumour necrosis factor -- implications for biological function.","publicationDate":"1990","journal":"J. Cell Sci. Suppl.","firstPage":"11","lastPage":"18","volume":"13"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS)"]},{"referenceNumber":35,"citation":{"id":"2551905","citationType":"journal article","authors":["Eck M.J.","Sprang S.R."],"citationCrossReferences":[{"database":"PubMed","id":"2551905"},{"database":"DOI","id":"10.2210/pdb1tnf/pdb"}],"title":"The structure of tumor necrosis factor-alpha at 2.6-A resolution. Implications for receptor binding.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"17595","lastPage":"17605","volume":"264"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS)"]},{"referenceNumber":36,"citation":{"id":"9488135","citationType":"journal article","authors":["Reed C.","Fu Z.Q.","Wu J.","Xue Y.N.","Harrison R.W.","Chen M.J.","Weber I.T."],"citationCrossReferences":[{"database":"PubMed","id":"9488135"},{"database":"DOI","id":"10.1093/protein/10.10.1101"}],"title":"Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2.","publicationDate":"1997","journal":"Protein Eng.","firstPage":"1101","lastPage":"1107","volume":"10"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF MUTANT ARG-107"]},{"referenceNumber":37,"citation":{"id":"9442056","citationType":"journal article","authors":["Cha S.S.","Kim J.S.","Cho H.S.","Shin N.K.","Jeong W.","Shin H.C.","Kim Y.J.","Hahn J.H.","Oh B.H."],"citationCrossReferences":[{"database":"PubMed","id":"9442056"},{"database":"DOI","id":"10.1074/jbc.273.4.2153"}],"title":"High resolution crystal structure of a human tumor necrosis factor-alpha mutant with low systemic toxicity.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"2153","lastPage":"2160","volume":"273"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF MUTANT SER-3"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M16441","properties":[{"key":"ProteinId","value":"AAA61200.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X02910","properties":[{"key":"ProteinId","value":"CAA26669.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X01394","properties":[{"key":"ProteinId","value":"CAA25650.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M10988","properties":[{"key":"ProteinId","value":"AAA61198.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M26331","properties":[{"key":"ProteinId","value":"AAA36758.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z15026","properties":[{"key":"ProteinId","value":"CAA78745.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Y14768","properties":[{"key":"ProteinId","value":"CAA75070.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF129756","properties":[{"key":"ProteinId","value":"AAD18091.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BA000025","properties":[{"key":"ProteinId","value":"BAB63396.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB088112","properties":[{"key":"ProteinId","value":"BAC54944.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY066019","properties":[{"key":"ProteinId","value":"AAL47581.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY214167","properties":[{"key":"ProteinId","value":"AAO21132.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC028148","properties":[{"key":"ProteinId","value":"AAH28148.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF043342","properties":[{"key":"ProteinId","value":"AAC03542.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF098751","properties":[{"key":"ProteinId","value":"AAF71992.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS4702.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A93585","properties":[{"key":"EntryName","value":"QWHUN"}]},{"database":"RefSeq","id":"NP_000585.2","properties":[{"key":"NucleotideSequenceId","value":"NM_000594.4"}]},{"database":"PDB","id":"1A8M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"1TNF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"21TV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.19 A"},{"key":"Chains","value":"B/C/D=77-233"}]},{"database":"PDB","id":"21TW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.43 A"},{"key":"Chains","value":"B/C/D=77-233"}]},{"database":"PDB","id":"2AZ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=86-233"}]},{"database":"PDB","id":"2E7A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"2TUN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDB","id":"2ZJC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"2ZPX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.83 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"3ALQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDB","id":"3IT8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B/C/G/H/I=82-233"}]},{"database":"PDB","id":"3L9J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"T=85-233"}]},{"database":"PDB","id":"3WD5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=77-233"}]},{"database":"PDB","id":"4G3Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"C=77-233"}]},{"database":"PDB","id":"4TSV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=84-233"}]},{"database":"PDB","id":"4TWT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"A/B/C/D=77-233"}]},{"database":"PDB","id":"4Y6O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"C/D=17-23"}]},{"database":"PDB","id":"5M2I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDB","id":"5M2J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=77-233"}]},{"database":"PDB","id":"5M2M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/G/I/M=77-233"}]},{"database":"PDB","id":"5MU8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C/D/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e=77-233"}]},{"database":"PDB","id":"5TSW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D/E/F=84-233"}]},{"database":"PDB","id":"5UUI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=77-233"}]},{"database":"PDB","id":"5WUX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"E/F/G=77-233"}]},{"database":"PDB","id":"5YOY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.73 A"},{"key":"Chains","value":"A/B/C/J/K/L=76-233"}]},{"database":"PDB","id":"6OOY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"6OOZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"6OP0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"6RMJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"6X81","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.81 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDB","id":"6X82","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDB","id":"6X83","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.83 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDB","id":"6X85","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDB","id":"6X86","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.93 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDB","id":"7ASY","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=28-60"}]},{"database":"PDB","id":"7AT7","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=28-60"}]},{"database":"PDB","id":"7ATB","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=28-60"}]},{"database":"PDB","id":"7JRA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"7KP9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"7KPA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"7KPB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"7QLF","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=178-191"}]},{"database":"PDB","id":"7TA3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/D=77-233"}]},{"database":"PDB","id":"7TA6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.67 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=77-233"}]},{"database":"PDB","id":"8Z8M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.59 A"},{"key":"Chains","value":"A/C/E/G/I/K=77-233"}]},{"database":"PDB","id":"8ZUI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.56 A"},{"key":"Chains","value":"A/B/C/G/H/I=77-233"}]},{"database":"PDB","id":"9BN7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.92 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"9DJW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.31 A"},{"key":"Chains","value":"2/3/4/A/B/C/G/H/I/M/N/O/S/T/U/Y/Z/a/e/f/g/k/l/m/q/r/s/w/x/y=78-233"}]},{"database":"PDB","id":"9OJO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.36 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"9OJS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B/C=77-233"}]},{"database":"PDB","id":"9OJY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.16 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDB","id":"9OK6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.78 A"},{"key":"Chains","value":"A/B/C/D/E/F=77-233"}]},{"database":"PDBsum","id":"1A8M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1TNF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"21TV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"21TW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2AZ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2E7A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2TUN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2ZJC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2ZPX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3ALQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3IT8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3L9J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3WD5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4G3Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4TSV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4TWT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Y6O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5M2I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5M2J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5M2M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MU8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5TSW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UUI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5WUX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YOY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6OOY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6OOZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6OP0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RMJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X81","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X82","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X83","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X85","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X86","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ASY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7AT7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ATB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JRA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KP9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KPA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KPB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7QLF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7TA3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7TA6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Z8M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ZUI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BN7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DJW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OJO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OJS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OJY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OK6","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60484","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60489","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60490","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60491","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60494","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60497","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60549","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-67993","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-67994","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112979","properties":[{"key":"Interactions","value":"349"}]},{"database":"ComplexPortal","id":"CPX-2805","properties":[{"key":"EntryName","value":"sTNF:TNR1B receptor-ligand complex"}]},{"database":"ComplexPortal","id":"CPX-8826","properties":[{"key":"EntryName","value":"Soluble tumor necrosis factor complex"}]},{"database":"ComplexPortal","id":"CPX-8931","properties":[{"key":"EntryName","value":"Transmembrane tumor necrosis factor complex"}]},{"database":"CORUM","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-2895N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P01375","properties":[{"key":"Number of interactors","value":"1671"}]},{"database":"IntAct","id":"P01375","properties":[{"key":"Interactions","value":"150"}]},{"database":"MINT","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-TNF","properties":[{"key":"Evidences","value":"123 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000398698","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1825","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB07145","properties":[{"key":"GenericName","value":"(2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE"}]},{"database":"DrugBank","id":"DB00051","properties":[{"key":"GenericName","value":"Adalimumab"}]},{"database":"DrugBank","id":"DB04956","properties":[{"key":"GenericName","value":"Afelimomab"}]},{"database":"DrugBank","id":"DB05879","properties":[{"key":"GenericName","value":"AME-527"}]},{"database":"DrugBank","id":"DB01427","properties":[{"key":"GenericName","value":"Amrinone"}]},{"database":"DrugBank","id":"DB05054","properties":[{"key":"GenericName","value":"AN0128"}]},{"database":"DrugBank","id":"DB05767","properties":[{"key":"GenericName","value":"Andrographolide"}]},{"database":"DrugBank","id":"DB05513","properties":[{"key":"GenericName","value":"Atiprimod"}]},{"database":"DrugBank","id":"DB16101","properties":[{"key":"GenericName","value":"Baicalein"}]},{"database":"DrugBank","id":"DB11752","properties":[{"key":"GenericName","value":"Bryostatin 1"}]},{"database":"DrugBank","id":"DB20694","properties":[{"key":"GenericName","value":"Camobucol"}]},{"database":"DrugBank","id":"DB18736","properties":[{"key":"GenericName","value":"Celastrol"}]},{"database":"DrugBank","id":"DB08904","properties":[{"key":"GenericName","value":"Certolizumab pegol"}]},{"database":"DrugBank","id":"DB00608","properties":[{"key":"GenericName","value":"Chloroquine"}]},{"database":"DrugBank","id":"DB01407","properties":[{"key":"GenericName","value":"Clenbuterol"}]},{"database":"DrugBank","id":"DB05744","properties":[{"key":"GenericName","value":"CRx-139"}]},{"database":"DrugBank","id":"DB05758","properties":[{"key":"GenericName","value":"CYT007-TNFQb"}]},{"database":"DrugBank","id":"DB06444","properties":[{"key":"GenericName","value":"Dexanabinol"}]},{"database":"DrugBank","id":"DB12140","properties":[{"key":"GenericName","value":"Dilmapimod"}]},{"database":"DrugBank","id":"DB00668","properties":[{"key":"GenericName","value":"Epinephrine"}]},{"database":"DrugBank","id":"DB00005","properties":[{"key":"GenericName","value":"Etanercept"}]},{"database":"DrugBank","id":"DB05869","properties":[{"key":"GenericName","value":"Ethyl pyruvate"}]},{"database":"DrugBank","id":"DB10770","properties":[{"key":"GenericName","value":"Foreskin fibroblast (neonatal)"}]},{"database":"DrugBank","id":"DB10772","properties":[{"key":"GenericName","value":"Foreskin keratinocyte (neonatal)"}]},{"database":"DrugBank","id":"DB13751","properties":[{"key":"GenericName","value":"Glycyrrhizic acid"}]},{"database":"DrugBank","id":"DB06674","properties":[{"key":"GenericName","value":"Golimumab"}]},{"database":"DrugBank","id":"DB00065","properties":[{"key":"GenericName","value":"Infliximab"}]},{"database":"DrugBank","id":"DB02325","properties":[{"key":"GenericName","value":"Isopropyl alcohol"}]},{"database":"DrugBank","id":"DB12193","properties":[{"key":"GenericName","value":"Lenabasum"}]},{"database":"DrugBank","id":"DB00480","properties":[{"key":"GenericName","value":"Lenalidomide"}]},{"database":"DrugBank","id":"DB12598","properties":[{"key":"GenericName","value":"Nafamostat"}]},{"database":"DrugBank","id":"DB05303","properties":[{"key":"GenericName","value":"OMS-103HP"}]},{"database":"DrugBank","id":"DB06495","properties":[{"key":"GenericName","value":"Onercept"}]},{"database":"DrugBank","id":"DB11669","properties":[{"key":"GenericName","value":"Ortataxel"}]},{"database":"DrugBank","id":"DB00806","properties":[{"key":"GenericName","value":"Pentoxifylline"}]},{"database":"DrugBank","id":"DB05992","properties":[{"key":"GenericName","value":"Plinabulin"}]},{"database":"DrugBank","id":"DB05218","properties":[{"key":"GenericName","value":"PN0621"}]},{"database":"DrugBank","id":"DB09221","properties":[{"key":"GenericName","value":"Polaprezinc"}]},{"database":"DrugBank","id":"DB08910","properties":[{"key":"GenericName","value":"Pomalidomide"}]},{"database":"DrugBank","id":"DB05968","properties":[{"key":"GenericName","value":"PR-104"}]},{"database":"DrugBank","id":"DB01411","properties":[{"key":"GenericName","value":"Pranlukast"}]},{"database":"DrugBank","id":"DB00852","properties":[{"key":"GenericName","value":"Pseudoephedrine"}]},{"database":"DrugBank","id":"DB06566","properties":[{"key":"GenericName","value":"RDP58"}]},{"database":"DrugBank","id":"DB05207","properties":[{"key":"GenericName","value":"SD118"}]},{"database":"DrugBank","id":"DB17894","properties":[{"key":"GenericName","value":"Senlizumab"}]},{"database":"DrugBank","id":"DB05412","properties":[{"key":"GenericName","value":"Talmapimod"}]},{"database":"DrugBank","id":"DB01041","properties":[{"key":"GenericName","value":"Thalidomide"}]},{"database":"DrugBank","id":"DB04297","properties":[{"key":"GenericName","value":"Trichostatin A"}]},{"database":"DrugBank","id":"DB05470","properties":[{"key":"GenericName","value":"VX-702"}]},{"database":"DrugBank","id":"DB16454","properties":[{"key":"GenericName","value":"XPro1595"}]},{"database":"DrugBank","id":"DB05017","properties":[{"key":"GenericName","value":"YSIL6"}]},{"database":"DrugCentral","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P01375","properties":[{"key":"glycosylation","value":"3 O-Linked glycans (1 site)"}]},{"database":"GlyCosmos","id":"P01375","properties":[{"key":"glycosylation","value":"1 site, 5 glycans"}]},{"database":"GlyGen","id":"P01375","properties":[{"key":"glycosylation","value":"1 site, 5 O-linked glycans (1 site)"}]},{"database":"iPTMnet","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TNF","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"135934","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000398698","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51379","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P01375","properties":[{"key":"antibodies","value":"210 sequenced antibodies"}]},{"database":"Antibodypedia","id":"27196","properties":[{"key":"antibodies","value":"5377 antibodies from 59 providers"}]},{"database":"DNASU","id":"7124","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000376122.3","properties":[{"key":"ProteinId","value":"ENSP00000365290.3"},{"key":"GeneId","value":"ENSG00000204490.3"}]},{"database":"Ensembl","id":"ENST00000383496.4","properties":[{"key":"ProteinId","value":"ENSP00000372988.4"},{"key":"GeneId","value":"ENSG00000206439.5"}]},{"database":"Ensembl","id":"ENST00000412275.2","properties":[{"key":"ProteinId","value":"ENSP00000392858.2"},{"key":"GeneId","value":"ENSG00000228321.3"}]},{"database":"Ensembl","id":"ENST00000420425.2","properties":[{"key":"ProteinId","value":"ENSP00000410668.2"},{"key":"GeneId","value":"ENSG00000228849.3"}]},{"database":"Ensembl","id":"ENST00000443707.2","properties":[{"key":"ProteinId","value":"ENSP00000389492.2"},{"key":"GeneId","value":"ENSG00000230108.3"}]},{"database":"Ensembl","id":"ENST00000448781.2","properties":[{"key":"ProteinId","value":"ENSP00000389490.2"},{"key":"GeneId","value":"ENSG00000223952.3"}]},{"database":"Ensembl","id":"ENST00000449264.3","properties":[{"key":"ProteinId","value":"ENSP00000398698.2"},{"key":"GeneId","value":"ENSG00000232810.5"}]},{"database":"GeneID","id":"7124","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:7124","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000449264.3","properties":[{"key":"ProteinId","value":"ENSP00000398698.2"},{"key":"RefSeqNucleotideId","value":"NM_000594.4"},{"key":"RefSeqProteinId","value":"NP_000585.2"}]},{"database":"AGR","id":"HGNC:11892","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA435","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7124","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"7124","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TNF","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11892","properties":[{"key":"GeneName","value":"TNF"}]},{"database":"HPA","id":"ENSG00000232810","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (bone marrow, lymphoid tissue)"}]},{"database":"MalaCards","id":"TNF","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"191160","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"607507","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"610424","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"611162","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"620977","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000232810","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000232810","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S4K8","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01060000248544","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_070352_3_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GATMLFC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9940698at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P01375","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-381340","properties":[{"key":"PathwayName","value":"Transcriptional regulation of white adipocyte differentiation"}]},{"database":"Reactome","id":"R-HSA-5357786","properties":[{"key":"PathwayName","value":"TNFR1-induced proapoptotic signaling"}]},{"database":"Reactome","id":"R-HSA-5357905","properties":[{"key":"PathwayName","value":"Regulation of TNFR1 signaling"}]},{"database":"Reactome","id":"R-HSA-5357956","properties":[{"key":"PathwayName","value":"TNFR1-induced NF-kappa-B signaling pathway"}]},{"database":"Reactome","id":"R-HSA-5626978","properties":[{"key":"PathwayName","value":"TNFR1-mediated ceramide production"}]},{"database":"Reactome","id":"R-HSA-5668541","properties":[{"key":"PathwayName","value":"TNFR2 non-canonical NF-kB pathway"}]},{"database":"Reactome","id":"R-HSA-6783783","properties":[{"key":"PathwayName","value":"Interleukin-10 signaling"}]},{"database":"Reactome","id":"R-HSA-6785807","properties":[{"key":"PathwayName","value":"Interleukin-4 and Interleukin-13 signaling"}]},{"database":"Reactome","id":"R-HSA-75893","properties":[{"key":"PathwayName","value":"TNF signaling"}]},{"database":"Reactome","id":"R-HSA-9942503","properties":[{"key":"PathwayName","value":"Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells)"}]},{"database":"SignaLink","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000232810","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"7124","properties":[{"key":"hits","value":"11 hits in 1165 CRISPR screens"}]},{"database":"ChiTaRS","id":"TNF","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P01375","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Tumor_necrosis_factor-alpha","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"7124","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P01375","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P01375","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"P01375","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000232810","properties":[{"key":"ExpressionPatterns","value":"Expressed in granulocyte and 90 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P01375","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18355445"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10443688"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12594207"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18355445"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21323571"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"3932069"}]},{"database":"GO","id":"GO:0045121","properties":[{"key":"GoTerm","value":"C:membrane raft"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17010968"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18355445"}]},{"database":"GO","id":"GO:0055037","properties":[{"key":"GoTerm","value":"C:recycling endosome"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0005125","properties":[{"key":"GoTerm","value":"F:cytokine activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10748004"}]},{"database":"GO","id":"GO:0140072","properties":[{"key":"GoTerm","value":"F:histone H3K9ac reader activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14512626"}]},{"database":"GO","id":"GO:0002020","properties":[{"key":"GoTerm","value":"F:protease binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12777399"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"ISS:UniProt"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17350185"}]},{"database":"GO","id":"GO:0005164","properties":[{"key":"GoTerm","value":"F:tumor necrosis factor receptor binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14512626"}]},{"database":"GO","id":"GO:0140374","properties":[{"key":"GoTerm","value":"P:antiviral innate immune response"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11773383"}]},{"database":"GO","id":"GO:0048143","properties":[{"key":"GoTerm","value":"P:astrocyte activation"},{"key":"GoEvidenceType","value":"NAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26753638"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007259","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway via JAK-STAT"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:1904646","properties":[{"key":"GoTerm","value":"P:cellular response to amyloid-beta"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071479","properties":[{"key":"GoTerm","value":"P:cellular response to ionizing radiation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22836756"}]},{"database":"GO","id":"GO:0071316","properties":[{"key":"GoTerm","value":"P:cellular response to nicotine"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18676776"}]},{"database":"GO","id":"GO:0071300","properties":[{"key":"GoTerm","value":"P:cellular response to retinoic acid"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097237","properties":[{"key":"GoTerm","value":"P:cellular response to toxic substance"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071346","properties":[{"key":"GoTerm","value":"P:cellular response to type II interferon"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002439","properties":[{"key":"GoTerm","value":"P:chronic inflammatory response to antigenic stimulus"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14512626"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050890","properties":[{"key":"GoTerm","value":"P:cognition"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"22277195"}]},{"database":"GO","id":"GO:0050966","properties":[{"key":"GoTerm","value":"P:detection of mechanical stimulus involved in sensory perception of pain"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048566","properties":[{"key":"GoTerm","value":"P:embryonic digestive tract development"},{"key":"GoEvidenceType","value":"IEP:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"20875417"}]},{"database":"GO","id":"GO:0072577","properties":[{"key":"GoTerm","value":"P:endothelial cell apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097191","properties":[{"key":"GoTerm","value":"P:extrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11577081"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16611992"}]},{"database":"GO","id":"GO:0008625","properties":[{"key":"GoTerm","value":"P:extrinsic apoptotic signaling pathway via death domain receptors"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18676776"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10748004"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22267480"}]},{"database":"GO","id":"GO:0090594","properties":[{"key":"GoTerm","value":"P:inflammatory response to wounding"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27830702"}]},{"database":"GO","id":"GO:0050901","properties":[{"key":"GoTerm","value":"P:leukocyte tethering or rolling"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10820279"}]},{"database":"GO","id":"GO:0031663","properties":[{"key":"GoTerm","value":"P:lipopolysaccharide-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097421","properties":[{"key":"GoTerm","value":"P:liver regeneration"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002281","properties":[{"key":"GoTerm","value":"P:macrophage activation involved in immune response"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0097527","properties":[{"key":"GoTerm","value":"P:necroptotic signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22265413"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22265414"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22817896"}]},{"database":"GO","id":"GO:1900222","properties":[{"key":"GoTerm","value":"P:negative regulation of amyloid-beta clearance"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:2001234","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"31124343"}]},{"database":"GO","id":"GO:1903347","properties":[{"key":"GoTerm","value":"P:negative regulation of bicellular tight junction assembly"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25816133"}]},{"database":"GO","id":"GO:0120190","properties":[{"key":"GoTerm","value":"P:negative regulation of bile acid secretion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043537","properties":[{"key":"GoTerm","value":"P:negative regulation of blood vessel endothelial cell migration"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22499991"}]},{"database":"GO","id":"GO:0061048","properties":[{"key":"GoTerm","value":"P:negative regulation of branching involved in lung morphogenesis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17350185"}]},{"database":"GO","id":"GO:0002719","properties":[{"key":"GoTerm","value":"P:negative regulation of cytokine production involved in immune response"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10443688"}]},{"database":"GO","id":"GO:0046325","properties":[{"key":"GoTerm","value":"P:negative regulation of D-glucose import across plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16895791"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17350185"}]},{"database":"GO","id":"GO:0001937","properties":[{"key":"GoTerm","value":"P:negative regulation of endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:2001240","properties":[{"key":"GoTerm","value":"P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10666185"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10748004"}]},{"database":"GO","id":"GO:0045599","properties":[{"key":"GoTerm","value":"P:negative regulation of fat cell differentiation"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16464856"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15345745"}]},{"database":"GO","id":"GO:0010459","properties":[{"key":"GoTerm","value":"P:negative regulation of heart rate"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032715","properties":[{"key":"GoTerm","value":"P:negative regulation of interleukin-6 production"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10443688"}]},{"database":"GO","id":"GO:0002037","properties":[{"key":"GoTerm","value":"P:negative regulation of L-glutamate import across plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050995","properties":[{"key":"GoTerm","value":"P:negative regulation of lipid catabolic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19032770"}]},{"database":"GO","id":"GO:0010888","properties":[{"key":"GoTerm","value":"P:negative regulation of lipid storage"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16464856"}]},{"database":"GO","id":"GO:1902894","properties":[{"key":"GoTerm","value":"P:negative regulation of miRNA transcription"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23878390"}]},{"database":"GO","id":"GO:0045930","properties":[{"key":"GoTerm","value":"P:negative regulation of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031642","properties":[{"key":"GoTerm","value":"P:negative regulation of myelination"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050768","properties":[{"key":"GoTerm","value":"P:negative regulation of neurogenesis"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20018408"}]},{"database":"GO","id":"GO:0045668","properties":[{"key":"GoTerm","value":"P:negative regulation of osteoblast differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0090324","properties":[{"key":"GoTerm","value":"P:negative regulation of oxidative phosphorylation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003085","properties":[{"key":"GoTerm","value":"P:negative regulation of systemic arterial blood pressure"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15345745"}]},{"database":"GO","id":"GO:0061044","properties":[{"key":"GoTerm","value":"P:negative regulation of vascular wound healing"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22499991"}]},{"database":"GO","id":"GO:0045071","properties":[{"key":"GoTerm","value":"P:negative regulation of viral genome replication"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10490959"}]},{"database":"GO","id":"GO:0045760","properties":[{"key":"GoTerm","value":"P:positive regulation of action potential"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1902004","properties":[{"key":"GoTerm","value":"P:positive regulation of amyloid-beta formation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16723520"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17389591"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22173242"}]},{"database":"GO","id":"GO:2000334","properties":[{"key":"GoTerm","value":"P:positive regulation of blood microparticle formation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24998411"}]},{"database":"GO","id":"GO:0070886","properties":[{"key":"GoTerm","value":"P:positive regulation of calcineurin-NFAT signaling cascade"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16803872"}]},{"database":"GO","id":"GO:0043123","properties":[{"key":"GoTerm","value":"P:positive regulation of canonical NF-kappaB signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16280327"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16611992"}]},{"database":"GO","id":"GO:0045785","properties":[{"key":"GoTerm","value":"P:positive regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23892569"}]},{"database":"GO","id":"GO:2000343","properties":[{"key":"GoTerm","value":"P:positive regulation of chemokine (C-X-C motif) ligand 2 production"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20551324"}]},{"database":"GO","id":"GO:0032722","properties":[{"key":"GoTerm","value":"P:positive regulation of chemokine production"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10490959"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10443688"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17922812"}]},{"database":"GO","id":"GO:1900017","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production involved in inflammatory response"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31824476"}]},{"database":"GO","id":"GO:2000573","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17350185"}]},{"database":"GO","id":"GO:0070374","properties":[{"key":"GoTerm","value":"P:positive regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18606301"}]},{"database":"GO","id":"GO:2001238","properties":[{"key":"GoTerm","value":"P:positive regulation of extrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031622","properties":[{"key":"GoTerm","value":"P:positive regulation of fever generation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0032724","properties":[{"key":"GoTerm","value":"P:positive regulation of fractalkine production"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11085990"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23817958"}]},{"database":"GO","id":"GO:0060252","properties":[{"key":"GoTerm","value":"P:positive regulation of glial cell proliferation"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2104886"}]},{"database":"GO","id":"GO:0051798","properties":[{"key":"GoTerm","value":"P:positive regulation of hair follicle development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:2000347","properties":[{"key":"GoTerm","value":"P:positive regulation of hepatocyte proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034116","properties":[{"key":"GoTerm","value":"P:positive regulation of heterotypic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10604883"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20551324"}]},{"database":"GO","id":"GO:0002639","properties":[{"key":"GoTerm","value":"P:positive regulation of immunoglobulin production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050729","properties":[{"key":"GoTerm","value":"P:positive regulation of inflammatory response"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"24966471"}]},{"database":"GO","id":"GO:0032731","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-1 beta production"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31124343"}]},{"database":"GO","id":"GO:0032741","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-18 production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0150129","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-33 production"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31824476"}]},{"database":"GO","id":"GO:0032755","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-6 production"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24299952"}]},{"database":"GO","id":"GO:0032757","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-8 production"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20551324"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23608026"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31824476"}]},{"database":"GO","id":"GO:0046330","properties":[{"key":"GoTerm","value":"P:positive regulation of JNK cascade"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17389591"}]},{"database":"GO","id":"GO:1904999","properties":[{"key":"GoTerm","value":"P:positive regulation of leukocyte adhesion to arterial endothelial cell"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22267480"}]},{"database":"GO","id":"GO:1904996","properties":[{"key":"GoTerm","value":"P:positive regulation of leukocyte adhesion to vascular endothelial cell"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26371161"}]},{"database":"GO","id":"GO:0010744","properties":[{"key":"GoTerm","value":"P:positive regulation of macrophage derived foam cell differentiation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19032770"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10748004"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12813029"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15310755"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18440775"}]},{"database":"GO","id":"GO:0051044","properties":[{"key":"GoTerm","value":"P:positive regulation of membrane protein ectodomain proteolysis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18373975"}]},{"database":"GO","id":"GO:1902895","properties":[{"key":"GoTerm","value":"P:positive regulation of miRNA transcription"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22499991"}]},{"database":"GO","id":"GO:0045840","properties":[{"key":"GoTerm","value":"P:positive regulation of mitotic nuclear division"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071677","properties":[{"key":"GoTerm","value":"P:positive regulation of mononuclear cell migration"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21319131"}]},{"database":"GO","id":"GO:0150078","properties":[{"key":"GoTerm","value":"P:positive regulation of neuroinflammatory response"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"22277195"},{"evidenceCode":"ECO:0000304","source":"PubMed","id":"26753638"}]},{"database":"GO","id":"GO:0043525","properties":[{"key":"GoTerm","value":"P:positive regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:1902565","properties":[{"key":"GoTerm","value":"P:positive regulation of neutrophil activation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045429","properties":[{"key":"GoTerm","value":"P:positive regulation of nitric oxide biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8383325"}]},{"database":"GO","id":"GO:1901224","properties":[{"key":"GoTerm","value":"P:positive regulation of non-canonical NF-kappaB signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20041225"}]},{"database":"GO","id":"GO:0045672","properties":[{"key":"GoTerm","value":"P:positive regulation of osteoclast differentiation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17888176"}]},{"database":"GO","id":"GO:0051897","properties":[{"key":"GoTerm","value":"P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0071803","properties":[{"key":"GoTerm","value":"P:positive regulation of podosome assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15220135"}]},{"database":"GO","id":"GO:0043068","properties":[{"key":"GoTerm","value":"P:positive regulation of programmed cell death"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16611992"}]},{"database":"GO","id":"GO:0045732","properties":[{"key":"GoTerm","value":"P:positive regulation of protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:AgBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18632959"}]},{"database":"GO","id":"GO:2000010","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to cell surface"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19366699"}]},{"database":"GO","id":"GO:1903078","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to plasma membrane"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0051222","properties":[{"key":"GoTerm","value":"P:positive regulation of protein transport"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15310755"}]},{"database":"GO","id":"GO:0031334","properties":[{"key":"GoTerm","value":"P:positive regulation of protein-containing complex assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12813029"}]},{"database":"GO","id":"GO:0043243","properties":[{"key":"GoTerm","value":"P:positive regulation of protein-containing complex disassembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12813029"}]},{"database":"GO","id":"GO:0048661","properties":[{"key":"GoTerm","value":"P:positive regulation of smooth muscle cell proliferation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16518841"}]},{"database":"GO","id":"GO:0050806","properties":[{"key":"GoTerm","value":"P:positive regulation of synaptic transmission"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:1901647","properties":[{"key":"GoTerm","value":"P:positive regulation of synoviocyte proliferation"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31124343"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15345745"}]},{"database":"GO","id":"GO:1904707","properties":[{"key":"GoTerm","value":"P:positive regulation of vascular associated smooth muscle cell proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0060557","properties":[{"key":"GoTerm","value":"P:positive regulation of vitamin D biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1690216"}]},{"database":"GO","id":"GO:0072659","properties":[{"key":"GoTerm","value":"P:protein localization to plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25816133"}]},{"database":"GO","id":"GO:0043122","properties":[{"key":"GoTerm","value":"P:regulation of canonical NF-kappaB signal transduction"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10748004"}]},{"database":"GO","id":"GO:2000351","properties":[{"key":"GoTerm","value":"P:regulation of endothelial cell apoptotic process"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10843670"}]},{"database":"GO","id":"GO:1903140","properties":[{"key":"GoTerm","value":"P:regulation of establishment of endothelial barrier"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25816133"}]},{"database":"GO","id":"GO:0045598","properties":[{"key":"GoTerm","value":"P:regulation of fat cell differentiation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0050796","properties":[{"key":"GoTerm","value":"P:regulation of insulin secretion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8383325"}]},{"database":"GO","id":"GO:2000377","properties":[{"key":"GoTerm","value":"P:regulation of reactive oxygen species metabolic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22836756"}]},{"database":"GO","id":"GO:0050807","properties":[{"key":"GoTerm","value":"P:regulation of synapse organization"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0051966","properties":[{"key":"GoTerm","value":"P:regulation of synaptic transmission, glutamatergic"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"22277195"}]},{"database":"GO","id":"GO:1905242","properties":[{"key":"GoTerm","value":"P:response to 3,3',5-triiodo-L-thyronine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0014823","properties":[{"key":"GoTerm","value":"P:response to activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001975","properties":[{"key":"GoTerm","value":"P:response to amphetamine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046677","properties":[{"key":"GoTerm","value":"P:response to antibiotic"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045471","properties":[{"key":"GoTerm","value":"P:response to ethanol"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009750","properties":[{"key":"GoTerm","value":"P:response to fructose"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051384","properties":[{"key":"GoTerm","value":"P:response to glucocorticoid"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10443688"}]},{"database":"GO","id":"GO:1990268","properties":[{"key":"GoTerm","value":"P:response to gold nanoparticle"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0140460","properties":[{"key":"GoTerm","value":"P:response to Gram-negative bacterium"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1904880","properties":[{"key":"GoTerm","value":"P:response to hydrogen sulfide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035900","properties":[{"key":"GoTerm","value":"P:response to isolation stress"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1902065","properties":[{"key":"GoTerm","value":"P:response to L-glutamate"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0036005","properties":[{"key":"GoTerm","value":"P:response to macrophage colony-stimulating factor"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031667","properties":[{"key":"GoTerm","value":"P:response to nutrient levels"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1905235","properties":[{"key":"GoTerm","value":"P:response to quercetin"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1904638","properties":[{"key":"GoTerm","value":"P:response to resveratrol"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009651","properties":[{"key":"GoTerm","value":"P:response to salt stress"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"18355445"}]},{"database":"GO","id":"GO:0009615","properties":[{"key":"GoTerm","value":"P:response to virus"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10490959"}]},{"database":"GO","id":"GO:0009410","properties":[{"key":"GoTerm","value":"P:response to xenobiotic stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003009","properties":[{"key":"GoTerm","value":"P:skeletal muscle contraction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034138","properties":[{"key":"GoTerm","value":"P:toll-like receptor 3 signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0033209","properties":[{"key":"GoTerm","value":"P:tumor necrosis factor-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10443688"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12813029"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15310755"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28159925"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31824476"}]},{"database":"GO","id":"GO:0010573","properties":[{"key":"GoTerm","value":"P:vascular endothelial growth factor production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12794819"}]},{"database":"GO","id":"GO:0042311","properties":[{"key":"GoTerm","value":"P:vasodilation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd00184","properties":[{"key":"EntryName","value":"TNF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.40:FF:000007","properties":[{"key":"EntryName","value":"Tumor necrosis factor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006053","properties":[{"key":"EntryName","value":"TNF"}]},{"database":"InterPro","id":"IPR002959","properties":[{"key":"EntryName","value":"TNF_alpha"}]},{"database":"InterPro","id":"IPR021184","properties":[{"key":"EntryName","value":"TNF_CS"}]},{"database":"InterPro","id":"IPR006052","properties":[{"key":"EntryName","value":"TNF_dom"}]},{"database":"InterPro","id":"IPR008983","properties":[{"key":"EntryName","value":"Tumour_necrosis_fac-like_dom"}]},{"database":"PANTHER","id":"PTHR11471:SF23","properties":[{"key":"EntryName","value":"TUMOR NECROSIS FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11471","properties":[{"key":"EntryName","value":"TUMOR NECROSIS FACTOR FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00229","properties":[{"key":"EntryName","value":"TNF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01234","properties":[{"key":"EntryName","value":"TNECROSISFCT"}]},{"database":"PRINTS","id":"PR01235","properties":[{"key":"EntryName","value":"TNFALPHA"}]},{"database":"SMART","id":"SM00207","properties":[{"key":"EntryName","value":"TNF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49842","properties":[{"key":"EntryName","value":"TNF-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00251","properties":[{"key":"EntryName","value":"THD_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50049","properties":[{"key":"EntryName","value":"THD_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL","length":233,"molWeight":25644,"crc64":"3DF90F96C9031FFE","md5":"60ADA54E69E411BCF6B08E9DACFF7A48"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"INTERACTION":48,"SUBCELLULAR LOCATION":5,"PTM":4,"POLYMORPHISM":2,"DISEASE":2,"SIMILARITY":1,"SEQUENCE CAUTION":2,"WEB RESOURCE":2},"countByFeatureType":{"Chain":6,"Topological domain":2,"Transmembrane":1,"Domain":1,"Site":5,"Modified residue":1,"Lipidation":2,"Glycosylation":1,"Disulfide bond":1,"Natural variant":2,"Mutagenesis":8,"Sequence conflict":3,"Helix":6,"Beta strand":16,"Turn":1},"uniParcId":"UPI000000D745"}}