{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P01344","secondaryAccessions":["B3KX48","B7WP08","C9JAF2","E3UN45","P78449","Q14299","Q1WM26","Q9UC68","Q9UC69"],"uniProtkbId":"IGF2_HUMAN","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1986-07-21","entryVersion":271,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:5466"}],"value":"Insulin-like growth factor 2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"6382022"}],"value":"Insulin-like growth factor II"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3881277"}],"value":"IGF-II"}]},{"fullName":{"value":"Somatomedin-A"}},{"fullName":{"value":"T3M-11-derived growth factor"}}],"contains":[{"recommendedName":{"fullName":{"value":"Insulin-like growth factor II Ala-25 Del"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16912056"}],"value":"Preptin"}}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:5466"}],"value":"IGF2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12586351"}],"value":"IGF-2"}],"orfNames":[{"value":"PP1446"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P09535"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28873464"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24593700"}],"value":"The insulin-like growth factors possess growth-promoting activity (By similarity). 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