ID   SOMA_PIG                Reviewed;         216 AA.
AC   P01248; Q28958; Q29045;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 2.
DT   04-NOV-2026, entry version 154.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3666458; DOI=10.1016/0378-1119(87)90294-0;
RA   Vize P.D., Wells J.R.E.;
RT   "Isolation and characterization of the porcine growth hormone gene.";
RL   Gene 55:339-344(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2182128; DOI=10.1016/0167-4781(90)90069-e;
RA   Kato Y., Shimokawa N., Kato T., Hirai T., Yoshihama K., Kawai H.,
RA   Hattori M.A., Ezashi T., Shimogori Y., Wakabayashi K.;
RT   "Porcine growth hormone: molecular cloning of cDNA and expression in
RT   bacterial and mammalian cells.";
RL   Biochim. Biophys. Acta 1048:290-293(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=2491309;
RA   Qi S.Z., Wang X.Z., Zhou S.W., Jia F., Wang H.Y., Xia L.I., Li J.;
RT   "Sequencing of porcine growth hormone cDNA.";
RL   Chin. J. Biotechnol. 5:27-32(1989).
RN   [4]
RP   PROTEIN SEQUENCE OF 27-30 AND 149-216, AND DISULFIDE BOND.
RX   PubMed=4918150; DOI=10.1016/s0021-9258(18)63011-x;
RA   Mills J.B., Howard S.C., Scapa S., Wilhelmi A.E.;
RT   "Cyanogen bromide cleavage and partial amino acid sequence of porcine
RT   growth hormone.";
RL   J. Biol. Chem. 245:3407-3415(1970).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 7-216.
RX   PubMed=6303731; DOI=10.1089/dna.1.1983.2.37;
RA   Seeburg P.H., Sias S., Adelman J., de Boer H.A., Hayflick J., Jhurani P.,
RA   Goeddel D.V., Heyneker H.L.;
RT   "Efficient bacterial expression of bovine and porcine growth hormones.";
RL   DNA 2:37-45(1983).
RN   [6]
RP   NUCLEOTIDE SEQUENCE OF 97-158.
RX   PubMed=1343826;
RA   Yang Q., Zhu B., Zhou S., Qi S.;
RT   "Cloning and partial sequencing of the porcine growth hormone (pGH) gene
RT   from pituitary gland.";
RL   Chin. J. Biotechnol. 8:227-233(1992).
RN   [7]
RP   NUCLEOTIDE SEQUENCE OF 5-57.
RA   Jiang Z.H., Rottmann O.J., Pirchner F.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA73478.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X53325; CAA37411.1; -; mRNA.
DR   EMBL; M17704; AAA31044.1; -; Genomic_DNA.
DR   EMBL; U19788; AAA73478.1; ALT_INIT; mRNA.
DR   EMBL; M27326; AAA31045.1; -; mRNA.
DR   EMBL; S72386; AAB29947.2; -; Genomic_DNA.
DR   EMBL; U73464; AAB17619.1; -; Genomic_DNA.
DR   PIR; JW0015; STPG.
DR   AlphaFoldDB; P01248; -.
DR   SMR; P01248; -.
DR   FunCoup; P01248; 848.
DR   STRING; 9823.ENSSSCP00000050738; -.
DR   PaxDb; 9823-ENSSSCP00000050738; -.
DR   Ensembl; ENSSSCT00035001704.1; ENSSSCP00035000543.1; ENSSSCG00035001304.1.
DR   Ensembl; ENSSSCT00055043259.1; ENSSSCP00055034420.1; ENSSSCG00055021962.1.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   InParanoid; P01248; -.
DR   OMA; AFCQSET; -.
DR   Reactome; R-SSC-1170546; Prolactin receptor signaling.
DR   Reactome; R-SSC-422085; Synthesis, secretion, and deacylation of Ghrelin.
DR   Reactome; R-SSC-982772; Growth hormone receptor signaling.
DR   Proteomes; UP000008227; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005131; F:growth hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IDA:BHF-UCL.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   CDD; cd10285; somatotropin_like; 1.
DR   FunFam; 1.20.1250.10:FF:000002; Growth hormone; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417:SF2; SOMATOTROPIN; 1.
DR   PANTHER; PTHR11417; SOMATOTROPIN,PROLACTIN; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Phosphoprotein; Reference proteome; Secreted; Signal; Zinc.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000269|PubMed:4918150"
FT   CHAIN           27..216
FT                   /note="Somatotropin"
FT                   /id="PRO_0000032995"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         198
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         131
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        78..189
FT                   /evidence="ECO:0000250"
FT   DISULFID        206..214
FT                   /evidence="ECO:0000269|PubMed:4918150"
FT   CONFLICT        9
FT                   /note="A -> V (in Ref. 5; AAA31045)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        22
FT                   /note="R -> Q (in Ref. 5; AAA31045)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        78
FT                   /note="C -> F (in Ref. 3; AAA73478)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        116
FT                   /note="Q -> T (in Ref. 3; AAA73478)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        195
FT                   /note="H -> N (in Ref. 4; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        203
FT                   /note="V -> L (in Ref. 3; AAA73478)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        206
FT                   /note="C -> S (in Ref. 3; AAA73478)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   216 AA;  24429 MW;  0216931D6BE76D14 CRC64;
     MAAGPRTSAL LAFALLCLPW TREVGAFPAM PLSSLFANAV LRAQHLHQLA ADTYKEFERA
     YIPEGQRYSI QNAQAAFCFS ETIPAPTGKD EAQQRSDVEL LRFSLLLIQS WLGPVQFLSR
     VFTNSLVFGT SDRVYEKLKD LEEGIQALMR ELEDGSPRAG QILKQTYDKF DTNLRSDDAL
     LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF
//