ID FSHB_HUMAN Reviewed; 129 AA. AC P01225; A2TF08; A5JVV3; Q14D61; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 02-SEP-2026, entry version 232. DE RecName: Full=Follitropin subunit beta; DE AltName: Full=Follicle-stimulating hormone beta subunit; DE Short=FSH-B; DE Short=FSH-beta; DE AltName: Full=Follitropin beta chain; DE Flags: Precursor; GN Name=FSHB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=2885163; DOI=10.1089/dna.1987.6.205; RA Watkins P.C., Eddy R., Beck A.K., Vellucci V., Leverone B., Tanzi R.E., RA Gusella J.F., Shows T.B.; RT "DNA sequence and regional assignment of the human follicle-stimulating RT hormone beta-subunit gene to the short arm of human chromosome 11."; RL DNA 6:205-212(1987). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND RP SUBUNIT. RX PubMed=2494176; DOI=10.1016/s0021-9258(18)83656-0; RA Keene J.L., Matzuk M.M., Otani T., Fauser B.C.J.M., Galway A.B., RA Hsueh A.J.W., Boime I.; RT "Expression of biologically active human follitropin in Chinese hamster RT ovary cells."; RL J. Biol. Chem. 264:4769-4775(1989). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3139991; DOI=10.1210/mend-2-9-806; RA Jameson J.L., Becker C.B., Lindell C.M., Habener J.F.; RT "Human follicle-stimulating hormone beta-subunit gene encodes multiple RT messenger ribonucleic acids."; RL Mol. Endocrinol. 2:806-815(1988). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Akbari Eidgahi M.R., Shaebani A.A., Nasr R.; RT "Follicle-stimulating hormone (FSHB) beta subunit genes."; RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP PROTEIN SEQUENCE OF 19-129. RX PubMed=3151250; DOI=10.1007/bf01024882; RA Shome B., Parlow A.F., Liu W.K., Nahm H.S., Wen T., Ward D.N.; RT "A reevaluation of the amino acid sequence of human follitropin beta- RT subunit."; RL J. Protein Chem. 7:325-339(1988). RN [9] RP PRELIMINARY PROTEIN SEQUENCE OF 19-129. RX PubMed=1249074; DOI=10.1016/s0021-9258(17)33791-2; RA Saxena B.B., Rathnam P.; RT "Amino acid sequence of the beta subunit of follicle-stimulating hormone RT from human pituitary glands."; RL J. Biol. Chem. 251:993-1005(1976). RN [10] RP PRELIMINARY PROTEIN SEQUENCE OF 19-129. RX PubMed=4835136; DOI=10.1210/jcem-39-1-203; RA Shome B., Parlow A.F.; RT "Human follicle stimulating hormone: first proposal for the amino acid RT sequence of the hormone-specific, beta subunit (hFSHb)."; RL J. Clin. Endocrinol. Metab. 39:203-205(1974). RN [11] RP FUNCTION. RX PubMed=407105; DOI=10.1016/s0015-0282(16)42734-2; RA Maroulis G.B., Parlow A.F., Marshall J.R.; RT "Isolated follicle-stimulating hormone deficiency in man."; RL Fertil. Steril. 28:818-822(1977). RN [12] RP PRELIMINARY ASSIGNMENT OF DISULFIDE BONDS. RX PubMed=6774759; DOI=10.1016/0005-2795(80)90084-7; RA Fujiki Y., Rathnam P., Saxena B.B.; RT "Studies on the disulfide bonds in human pituitary follicle-stimulating RT hormone."; RL Biochim. Biophys. Acta 624:428-435(1980). RN [13] RP DISULFIDE BONDS. RX PubMed=11501762; DOI=10.1515/bc.2001.120; RA Amoresano A., Orru S., Siciliano R.A., De Luca E., Napoleoni R., Sirna A., RA Pucci P.; RT "Assignment of the complete disulphide bridge pattern in the human RT recombinant follitropin beta-chain."; RL Biol. Chem. 382:961-968(2001). RN [14] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF MUTANT ALA-27. RX PubMed=11222739; DOI=10.1210/mend.15.3.0603; RA Fox K.M., Dias J.A., Van Roey P.; RT "Three-dimensional structure of human follicle-stimulating hormone."; RL Mol. Endocrinol. 15:378-389(2001). RN [15] RP X-RAY CRYSTALLOGRAPHY (2.92 ANGSTROMS) OF 19-129 IN COMPLEX WITH CGA AND RP FSHR, DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-25 AND ASN-42. RX PubMed=15662415; DOI=10.1038/nature03206; RA Fan Q.R., Hendrickson W.A.; RT "Structure of human follicle-stimulating hormone in complex with its RT receptor."; RL Nature 433:269-277(2005). RN [16] {ECO:0007744|PDB:4MQW} RP X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 19-129 IN COMPLEX WITH CGA AND RP FSHR, GLYCOSYLATION AT ASN-25 AND ASN-42, FUNCTION, SUBUNIT, DISULFIDE RP BONDS, AND MUTAGENESIS OF THR-78. RX PubMed=24692546; DOI=10.1074/jbc.m114.549592; RA Jiang X., Fischer D., Chen X., McKenna S.D., Liu H., Sriraman V., Yu H.N., RA Goutopoulos A., Arkinstall S., He X.; RT "Evidence for follicle-stimulating hormone receptor as a functional RT trimer."; RL J. Biol. Chem. 289:14273-14282(2014). RN [17] RP INVOLVEMENT IN HH24, AND FUNCTION. RX PubMed=8220432; DOI=10.1038/ng0993-83; RA Matthews C.H., Borgato S., Beck-Peccoz P., Adams M., Tone Y., Gambino G., RA Casagrande S., Tedeschini G., Benedetti A., Chatterjee V.K.K.; RT "Primary amenorrhoea and infertility due to a mutation in the beta-subunit RT of follicle-stimulating hormone."; RL Nat. Genet. 5:83-86(1993). RN [18] RP VARIANT HH24 GLY-69. RX PubMed=9271483; DOI=10.1056/nejm199708283370905; RA Layman L.C., Lee E.-J., Peak D.B., Namnoum A.B., Vu K.V., van Lingen B.L., RA Gray M.R., McDonough P.G., Reindollar R.H., Jameson J.L.; RT "Delayed puberty and hypogonadism caused by mutations in the follicle- RT stimulating hormone beta-subunit gene."; RL N. Engl. J. Med. 337:607-611(1997). RN [19] RP INVOLVEMENT IN HH24. RX PubMed=9280841; DOI=10.1056/nejm199708283370918; RA Matthews C., Chatterjee V.K.; RT "Isolated deficiency of follicle-stimulating hormone re-revisited."; RL N. Engl. J. Med. 337:642-642(1997). RN [20] RP VARIANT ILE-20. RX PubMed=10391209; DOI=10.1038/10290; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions of RT human genes."; RL Nat. Genet. 22:231-238(1999). RN [21] RP ERRATUM OF PUBMED:10391209. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: Together with the alpha chain CGA constitutes follitropin, CC the follicle-stimulating hormone, and provides its biological CC specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled CC receptor, on target cells to activate downstream signaling pathways CC (PubMed:24692546, PubMed:2494176). Follitropin is involved in follicle CC development and spermatogenesis in reproductive organs (PubMed:407105, CC PubMed:8220432). {ECO:0000269|PubMed:24692546, CC ECO:0000269|PubMed:2494176, ECO:0000269|PubMed:407105, CC ECO:0000269|PubMed:8220432}. CC -!- SUBUNIT: Heterodimer. The active follitropin is a heterodimer composed CC of an alpha chain/CGA shared with other hormones and a unique beta CC chain/FSHB shown here. {ECO:0000269|PubMed:15662415, CC ECO:0000269|PubMed:24692546, ECO:0000269|PubMed:2494176}. CC -!- INTERACTION: CC P01225; P01215: CGA; NbExp=4; IntAct=EBI-1030645, EBI-718913; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2494176}. CC Note=Efficient secretion requires dimerization with CGA. CC {ECO:0000269|PubMed:2494176}. CC -!- DISEASE: Hypogonadotropic hypogonadism 24 with or without anosmia CC (HH24) [MIM:229070]: A form of hypogonadotropic hypogonadism, a group CC of disorders characterized by absent or incomplete sexual maturation by CC the age of 18 years, in conjunction with low levels of circulating CC gonadotropins and testosterone and no other abnormalities of the CC hypothalamic-pituitary axis. HH24 is characterized by primary CC amenorrhea in women, oligo or azoospermia with low to normal CC testosterone levels in men, and infertility. CC {ECO:0000269|PubMed:8220432, ECO:0000269|PubMed:9271483, CC ECO:0000269|PubMed:9280841}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- PHARMACEUTICAL: Available under the names Gonal-F or Metrodin HP CC (Serono) and Puregon (Organon). Used in the treatment of infertility in CC women with proven hypopituitarism or who have not responded to CC clomifene; or in superovulation treatment for assisted conception (such CC as in vitro fertilization). Metrodin HP is also used in the treatment CC of hypogonadotrophic hypogonadism in men for the stimulation of CC spermatogenesis. CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family. CC {ECO:0000305}. CC -!- WEB RESOURCE: Name=Wikipedia; Note=Follicle-stimulating hormone entry; CC URL="https://en.wikipedia.org/wiki/Follicle_stimulating_hormone"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M16647; AAA52476.1; -; Genomic_DNA. DR EMBL; M16646; AAA52476.1; JOINED; Genomic_DNA. DR EMBL; M24540; AAA52470.1; -; Genomic_DNA. DR EMBL; M24539; AAA52470.1; JOINED; Genomic_DNA. DR EMBL; M54914; AAB02868.1; -; Genomic_DNA. DR EMBL; M54913; AAB02868.1; JOINED; Genomic_DNA. DR EMBL; EF198021; ABM88373.1; -; Genomic_DNA. DR EMBL; EF585489; ABQ57401.1; -; mRNA. DR EMBL; EF585490; ABQ57402.1; -; Genomic_DNA. DR EMBL; EU081884; ABU96749.1; -; Genomic_DNA. DR EMBL; EU081885; ABU96750.1; -; Genomic_DNA. DR EMBL; AL358944; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471064; EAW68260.1; -; Genomic_DNA. DR EMBL; BC113488; AAI13489.1; -; mRNA. DR EMBL; BC113490; AAI13491.1; -; mRNA. DR CCDS; CCDS7868.1; -. DR PIR; A40920; FTHUB. DR RefSeq; NP_000501.1; NM_000510.4. DR RefSeq; NP_001018090.1; NM_001018080.3. DR RefSeq; NP_001369218.1; NM_001382289.1. DR PDB; 1FL7; X-ray; 3.00 A; B/D=19-129. DR PDB; 1XWD; X-ray; 2.92 A; B/E=19-129. DR PDB; 4AY9; X-ray; 2.50 A; B/E/H=19-129. DR PDB; 4MQW; X-ray; 2.90 A; B/E/H=19-129. DR PDB; 8I2G; EM; 2.80 A; Y=19-127. DR PDB; 9YXD; X-ray; 2.29 A; B=19-129. DR AlphaFoldDB; P01225; -. DR EMDB; EMD-35135; -. DR MDposit; P01225; -. DR SMR; P01225; -. DR BioGRID; 108766; 1. DR ComplexPortal; CPX-665; Follicle-stimulating hormone complex. DR DIP; DIP-35604N; -. DR ELM; P01225; -. DR FunCoup; P01225; 635. DR IntAct; P01225; 3. DR NDEx; IQUERY-CP-FSHB; 3 NDEx IQuery Curated Pathways. DR STRING; 9606.ENSP00000416606; -. DR GlyConnect; P01225; 10 N-Linked glycans. DR GlyCosmos; P01225; 2 sites, 28 glycans. DR GlyGen; P01225; 3 sites, 28 N-linked glycans (3 sites). DR iPTMnet; P01225; -. DR PhosphoSitePlus; P01225; -. DR SwissPalm; P01225; -. DR BioMuta; FSHB; -. DR DMDM; 120552; -. DR MassIVE; P01225; -. DR PaxDb; 9606-ENSP00000416606; -. DR PeptideAtlas; P01225; -. DR ProteomicsDB; 51348; -. DR Antibodypedia; 12775; 1051 antibodies from 41 providers. DR DNASU; 2488; -. DR Ensembl; ENST00000254122.8; ENSP00000254122.3; ENSG00000131808.11. DR Ensembl; ENST00000417547.1; ENSP00000416606.1; ENSG00000131808.11. DR Ensembl; ENST00000533718.2; ENSP00000433424.1; ENSG00000131808.11. DR GeneID; 2488; -. DR KEGG; hsa:2488; -. DR MANE-Select; ENST00000533718.2; ENSP00000433424.1; NM_001382289.1; NP_001369218.1. DR UCSC; uc001msl.4; human. DR AGR; HGNC:3964; -. DR ClinPGx; PA28382; -. DR CTD; 2488; -. DR DisGeNET; 2488; -. DR GeneCards; FSHB; -. DR HGNC; HGNC:3964; FSHB. DR HPA; ENSG00000131808; Tissue enriched (pituitary). DR MalaCards; FSHB; -. DR MIM; 136530; gene. DR MIM; 229070; phenotype. DR OpenTargets; ENSG00000131808; -. DR Orphanet; 52901; Isolated follicle stimulating hormone deficiency. DR VEuPathDB; HostDB:ENSG00000131808; -. DR eggNOG; ENOG502S39C; Eukaryota. DR GeneTree; ENSGT00940000160051; -. DR HOGENOM; CLU_126319_3_0_1; -. DR InParanoid; P01225; -. DR OMA; PVATGCH; -. DR OrthoDB; 8453657at2759; -. DR PAN-GO; P01225; 4 GO annotations based on evolutionary models. DR PhylomeDB; P01225; -. DR PathwayCommons; P01225; -. DR Reactome; R-HSA-209822; Glycoprotein hormones. DR Reactome; R-HSA-375281; Hormone ligand-binding receptors. DR Reactome; R-HSA-418555; G alpha (s) signalling events. DR SABIO-RK; P01225; -. DR SignaLink; P01225; -. DR SIGNOR; P01225; -. DR Agora; ENSG00000131808; -. DR BioGRID-ORCS; 2488; 6 hits in 1139 CRISPR screens. DR EvolutionaryTrace; P01225; -. DR GeneWiki; FSHB; -. DR GenomeRNAi; 2488; -. DR Pharos; P01225; Tbio. DR PRO; PR:P01225; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; P01225; protein. DR Bgee; ENSG00000131808; Expressed in adenohypophysis and 46 other cell types or tissues. DR ExpressionAtlas; P01225; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB. DR GO; GO:0016914; C:follicle-stimulating hormone complex; IDA:UniProtKB. DR GO; GO:0043235; C:signaling receptor complex; IPI:ComplexPortal. DR GO; GO:0016913; F:follicle-stimulating hormone activity; IDA:UniProtKB. DR GO; GO:0005102; F:signaling receptor binding; IEA:UniProtKB-ARBA. DR GO; GO:0007292; P:female gamete generation; TAS:ProtInc. DR GO; GO:0007565; P:female pregnancy; TAS:ProtInc. DR GO; GO:0042699; P:follicle-stimulating hormone signaling pathway; IBA:GO_Central. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB. DR GO; GO:0035773; P:insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl. DR GO; GO:0000165; P:MAPK cascade; NAS:ComplexPortal. DR GO; GO:0001541; P:ovarian follicle development; IBA:GO_Central. DR GO; GO:0030335; P:positive regulation of cell migration; NAS:BHF-UCL. DR GO; GO:0008284; P:positive regulation of cell population proliferation; NAS:BHF-UCL. DR GO; GO:0010893; P:positive regulation of steroid biosynthetic process; IDA:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; NAS:BHF-UCL. DR GO; GO:0006701; P:progesterone biosynthetic process; TAS:BHF-UCL. DR GO; GO:0007283; P:spermatogenesis; NAS:ComplexPortal. DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEP:BHF-UCL. DR CDD; cd00069; GHB_like; 1. DR FunFam; 2.10.90.10:FF:000007; Luteinizing hormone beta subunit; 1. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR006208; Glyco_hormone_CN. DR InterPro; IPR001545; Gonadotropin_bsu. DR InterPro; IPR018245; Gonadotropin_bsu_CS. DR PANTHER; PTHR11515:SF17; FOLLITROPIN SUBUNIT BETA; 1. DR PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1. DR Pfam; PF00007; Cys_knot; 1. DR SMART; SM00068; GHB; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1. DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1. DR PDBsum; 1FL7; -. DR PDBsum; 1XWD; -. DR PDBsum; 4AY9; -. DR PDBsum; 4MQW; -. DR PDBsum; 8I2G; -. DR PDBsum; 9YXD; -. PE 1: Evidence at protein level; KW 3D-structure; Direct protein sequencing; Disease variant; Disulfide bond; KW Glycoprotein; Hormone; Hypogonadotropic hypogonadism; Pharmaceutical; KW Proteomics identification; Reference proteome; Secreted; Signal. FT SIGNAL 1..18 FT /evidence="ECO:0000269|PubMed:3151250" FT CHAIN 19..129 FT /note="Follitropin subunit beta" FT /id="PRO_0000011711" FT CARBOHYD 25 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:15662415, FT ECO:0000269|PubMed:4835136, ECO:0007744|PDB:4MQW" FT CARBOHYD 42 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:15662415, FT ECO:0000269|PubMed:4835136, ECO:0007744|PDB:4MQW" FT DISULFID 21..69 FT /evidence="ECO:0000269|PubMed:24692546, FT ECO:0007744|PDB:4MQW" FT DISULFID 35..84 FT /evidence="ECO:0000269|PubMed:24692546, FT ECO:0007744|PDB:4MQW" FT DISULFID 38..122 FT /evidence="ECO:0000269|PubMed:24692546, FT ECO:0007744|PDB:4MQW" FT DISULFID 46..100 FT /evidence="ECO:0000269|PubMed:24692546, FT ECO:0007744|PDB:4MQW" FT DISULFID 50..102 FT /evidence="ECO:0000269|PubMed:24692546, FT ECO:0007744|PDB:4MQW" FT DISULFID 105..112 FT /evidence="ECO:0000269|PubMed:24692546, FT ECO:0007744|PDB:4MQW" FT VARIANT 20 FT /note="S -> I (in dbSNP:rs6170)" FT /evidence="ECO:0000269|PubMed:10391209" FT /id="VAR_012047" FT VARIANT 69 FT /note="C -> G (in HH24; dbSNP:rs5030776)" FT /evidence="ECO:0000269|PubMed:9271483" FT /id="VAR_033015" FT MUTAGEN 78 FT /note="T->E: Increased activation of the FT follicle-stimulating hormone signaling pathway." FT /evidence="ECO:0000269|PubMed:24692546" FT STRAND 21..32 FT /evidence="ECO:0007829|PDB:4AY9" FT HELIX 33..35 FT /evidence="ECO:0007829|PDB:4AY9" FT STRAND 37..53 FT /evidence="ECO:0007829|PDB:4AY9" FT STRAND 68..81 FT /evidence="ECO:0007829|PDB:4AY9" FT STRAND 85..87 FT /evidence="ECO:0007829|PDB:4MQW" FT STRAND 90..103 FT /evidence="ECO:0007829|PDB:4AY9" FT TURN 107..109 FT /evidence="ECO:0007829|PDB:4AY9" FT STRAND 110..114 FT /evidence="ECO:0007829|PDB:4AY9" SQ SEQUENCE 129 AA; 14700 MW; 9D2AF00DD76B8E2B CRC64; MKTLQFFFLF CCWKAICCNS CELTNITIAI EKEECRFCIS INTTWCAGYC YTRDLVYKDP ARPKIQKTCT FKELVYETVR VPGCAHHADS LYTYPVATQC HCGKCDSDST DCTVRGLGPS YCSFGEMKE //