{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P01193","secondaryAccessions":["P01200","Q544U4"],"uniProtkbId":"COLI_MOUSE","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1986-07-21","entryVersion":196,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Pro-opiomelanocortin"},"shortNames":[{"value":"POMC"}]},"alternativeNames":[{"fullName":{"value":"Corticotropin-lipotropin"}}],"contains":[{"recommendedName":{"fullName":{"value":"NPP"}}},{"recommendedName":{"fullName":{"value":"Melanotropin gamma"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9413988"}],"value":"Gamma-MSH"}}]},{"recommendedName":{"fullName":{"value":"Corticotropin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35926007"}],"value":"Adrenocorticotropic hormone"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9413988"}],"value":"ACTH"}]}]},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35926007"}],"value":"Melanocyte-stimulating hormone alpha"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35926007"}],"value":"Alpha-MSH"}]},"alternativeNames":[{"fullName":{"value":"Melanotropin alpha"}}]},{"recommendedName":{"fullName":{"value":"Corticotropin-like intermediary peptide"},"shortNames":[{"value":"CLIP"}]}},{"recommendedName":{"fullName":{"value":"Lipotropin beta"}},"alternativeNames":[{"fullName":{"value":"Beta-LPH"}}]},{"recommendedName":{"fullName":{"value":"Lipotropin gamma"}},"alternativeNames":[{"fullName":{"value":"Gamma-LPH"}}]},{"recommendedName":{"fullName":{"value":"Melanocyte-stimulating hormone beta"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9413988"}],"value":"Beta-MSH"}]},"alternativeNames":[{"fullName":{"value":"Melanotropin beta"}}]},{"recommendedName":{"fullName":{"value":"Beta-endorphin"}}},{"recommendedName":{"fullName":{"value":"Met-enkephalin"}}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:97742"}],"value":"Pomc"},"synonyms":[{"value":"Pomc1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P01189"}],"value":"Precursor protein of pituitary hormones that are involved in diverse physiological processes, including the regulation of energy balance, stress response, immune function and skin pigmentation"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P01189"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9413988"}],"value":"Functions as a ligand for the melanocortin receptors MC1R, MC2R, MC3R and MC5R (PubMed:9413988). Activation of MC1R increases melanogenesis in melanocytes found in the skin and hair. Binding to MC2R stimulates the adrenal glands to secrete cortisol. Contributes to the regulation of energy homeostasis through activation of MC3R (By similarity). Involved in the regulation exocrine gland function through MC5R activation (PubMed:9413988)"}],"commentType":"FUNCTION","molecule":"Corticotropin"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P01189"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35926007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9413988"}],"value":"Serves as a ligand for the melanocortin receptors MC1R, MC3R, MC4R and MC5R (PubMed:35926007, PubMed:9413988). Activation of MC1R promotes melanogenesis in melanocytes of the skin and hair. Contributes to the regulation of energy homeostasis through activation of MC3R. Through MC4R activation, functions as an anorexigenic peptide (By similarity). Promotes immunosuppression and involved in the regulation exocrine gland function through MC5R activation (PubMed:35926007, PubMed:9413988)"}],"commentType":"FUNCTION","molecule":"Melanocyte-stimulating hormone alpha"},{"texts":[{"value":"Endogenous orexigenic opiate"}],"commentType":"FUNCTION","molecule":"Beta-endorphin"},{"texts":[{"value":"Endogenous opiate"}],"commentType":"FUNCTION","molecule":"Met-enkephalin"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25707796"}],"value":"Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25707796"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"value":"ACTH and MSH are produced by the pituitary gland"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25707796"}],"value":"In hypothalamic paraventricular nucleus (PVN), up-regulated by cannabinoids, including the CNR1/CB1R agonist arachidonyl-29-chloroethylamide (ACEA) (at protein level)"}],"commentType":"INDUCTION","molecule":"Beta-endorphin"},{"texts":[{"value":"Specific enzymatic cleavages at paired basic residues yield the different active peptides"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the POMC family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Peptide","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"NPP","featureId":"PRO_0000024996"},{"type":"Peptide","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Melanotropin gamma","featureId":"PRO_0000024997"},{"type":"Propeptide","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","featureId":"PRO_0000024998"},{"type":"Peptide","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"Corticotropin","featureId":"PRO_0000024999"},{"type":"Peptide","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Melanocyte-stimulating hormone alpha","featureId":"PRO_0000025000"},{"type":"Peptide","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"Corticotropin-like intermediary peptide","featureId":"PRO_0000025001"},{"type":"Peptide","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Lipotropin beta","featureId":"PRO_0000025002"},{"type":"Peptide","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Lipotropin gamma","featureId":"PRO_0000025003"},{"type":"Peptide","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Melanocyte-stimulating hormone beta","featureId":"PRO_0000025004"},{"type":"Peptide","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Beta-endorphin","featureId":"PRO_0000025005"},{"type":"Peptide","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Met-enkephalin","featureId":"PRO_0000025006"},{"type":"Region","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Phenylalanine amide","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"N-acetylserine; in Corticotropin","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P01191"}]},{"type":"Modified residue","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Valine amide","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P01189"}]},{"type":"Glycosylation","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Sequence conflict","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in Ref. 2; CAA24770","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0027","category":"PTM","name":"Amidation"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0257","category":"Molecular function","name":"Endorphin"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0372","category":"Molecular function","name":"Hormone"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"6303853","citationType":"journal article","authors":["Notake M.","Tobimatsu T.","Watanabe Y.","Takahashi H.","Mishina M.","Numa S."],"citationCrossReferences":[{"database":"PubMed","id":"6303853"},{"database":"DOI","id":"10.1016/0014-5793(83)80250-6"}],"title":"Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene.","publicationDate":"1983","journal":"FEBS Lett.","firstPage":"67","lastPage":"71","volume":"156"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"6308009","citationType":"journal article","authors":["Uhler M.","Herbert E.","D'Eustachio P.","Ruddle F.D."],"citationCrossReferences":[{"database":"PubMed","id":"6308009"},{"database":"DOI","id":"10.1016/s0021-9258(17)44688-6"}],"title":"The mouse genome contains two nonallelic pro-opiomelanocortin genes.","publicationDate":"1983","journal":"J. Biol. Chem.","firstPage":"9444","lastPage":"9453","volume":"258"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"2536749","citationType":"journal article","authors":["Thorne B.A.","Caton L.W.","Thomas G."],"citationCrossReferences":[{"database":"PubMed","id":"2536749"},{"database":"DOI","id":"10.1016/s0021-9258(18)94100-1"}],"title":"Expression of mouse proopiomelanocortin in an insulinoma cell line. Requirements for beta-endorphin processing.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"3545","lastPage":"3552","volume":"264"},"referencePositions":["NUCLEOTIDE SEQUENCE OF 1-36"]},{"referenceNumber":6,"citation":{"id":"1689057","citationType":"journal article","authors":["Smith E.M.","Galin F.S.","Leboeuf R.D.","Coppenhaver D.H.","Harbour D.V.","Blalock E.J."],"citationCrossReferences":[{"database":"PubMed","id":"1689057"},{"database":"DOI","id":"10.1073/pnas.87.3.1057"}],"title":"Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide.","publicationDate":"1990","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1057","lastPage":"1060","volume":"87"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 124-162"],"referenceComments":[{"value":"C3H/HeJ","type":"STRAIN"},{"value":"Lymphocyte","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"221916","citationType":"journal article","authors":["Roberts J.L.","Seeburg P.H.","Shine J.","Herbert E.","Baxter J.D.","Goodman H.M."],"citationCrossReferences":[{"database":"PubMed","id":"221916"},{"database":"DOI","id":"10.1073/pnas.76.5.2153"}],"title":"Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor.","publicationDate":"1979","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2153","lastPage":"2157","volume":"76"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-234"]},{"referenceNumber":8,"citation":{"id":"9413988","citationType":"journal article","authors":["Chen W.","Kelly M.A.","Opitz-Araya X.","Thomas R.E.","Low M.J.","Cone R.D."],"citationCrossReferences":[{"database":"PubMed","id":"9413988"},{"database":"DOI","id":"10.1016/s0092-8674(00)80467-5"}],"title":"Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides.","publicationDate":"1997","journal":"Cell","firstPage":"789","lastPage":"798","volume":"91"},"referencePositions":["FUNCTION (ACTH AND ALPHA-MSH)"]},{"referenceNumber":9,"citation":{"id":"25707796","citationType":"journal article","authors":["Koch M.","Varela L.","Kim J.G.","Kim J.D.","Hernandez-Nuno F.","Simonds S.E.","Castorena C.M.","Vianna C.R.","Elmquist J.K.","Morozov Y.M.","Rakic P.","Bechmann I.","Cowley M.A.","Szigeti-Buck K.","Dietrich M.O.","Gao X.B.","Diano S.","Horvath T.L."],"citationCrossReferences":[{"database":"PubMed","id":"25707796"},{"database":"DOI","id":"10.1038/nature14260"}],"title":"Hypothalamic POMC neurons promote cannabinoid-induced feeding.","publicationDate":"2015","journal":"Nature","firstPage":"45","lastPage":"50","volume":"519"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION BY CANNABINOID"]},{"referenceNumber":10,"citation":{"id":"35926007","citationType":"journal article","authors":["Xu Y.","Yan J.","Tao Y.","Qian X.","Zhang C.","Yin L.","Gu P.","Liu Y.","Pan Y.","Tang R.","Jiang W.","Zhou R."],"citationCrossReferences":[{"database":"PubMed","id":"35926007"},{"database":"DOI","id":"10.1126/science.abj2674"}],"title":"Pituitary hormone alpha-MSH promotes tumor-induced myelopoiesis and immunosuppression.","publicationDate":"2022","journal":"Science","firstPage":"1085","lastPage":"1091","volume":"377"},"referencePositions":["FUNCTION (ALPHA-MSH)"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"J00612","properties":[{"key":"ProteinId","value":"AAB59729.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J00611","properties":[{"key":"ProteinId","value":"AAB59729.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"V01528","properties":[{"key":"ProteinId","value":"CAA24769.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"V01529","properties":[{"key":"ProteinId","value":"CAA24770.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK017492","properties":[{"key":"ProteinId","value":"BAB30771.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK017581","properties":[{"key":"ProteinId","value":"BAB30818.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK030714","properties":[{"key":"ProteinId","value":"BAC27095.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK077426","properties":[{"key":"ProteinId","value":"BAC36795.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK133592","properties":[{"key":"ProteinId","value":"BAE21739.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK133646","properties":[{"key":"ProteinId","value":"BAE21764.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK133740","properties":[{"key":"ProteinId","value":"BAE21815.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK133776","properties":[{"key":"ProteinId","value":"BAE21833.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK133800","properties":[{"key":"ProteinId","value":"BAE21850.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC061215","properties":[{"key":"ProteinId","value":"AAH61215.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M30489","properties":[{"key":"ProteinId","value":"AAA37169.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"V00831","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS25785.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A91312","properties":[{"key":"EntryName","value":"CTMSP"}]},{"database":"RefSeq","id":"NP_001265510.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001278581.1"}]},{"database":"RefSeq","id":"NP_001265511.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001278582.1"}]},{"database":"RefSeq","id":"NP_001265512.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001278583.1"}]},{"database":"RefSeq","id":"NP_001265513.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001278584.1"}]},{"database":"RefSeq","id":"NP_032921.1","properties":[{"key":"NucleotideSequenceId","value":"NM_008895.4"}]},{"database":"AlphaFoldDB","id":"P01193","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P01193","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P01193","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"202295","properties":[{"key":"Interactions","value":"1"}]},{"database":"ELM","id":"P01193","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P01193","properties":[{"key":"Number of interactors","value":"756"}]},{"database":"STRING","id":"10090.ENSMUSP00000151504","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P01193","properties":[{"key":"glycosylation","value":"5 N-Linked glycans (1 site)"}]},{"database":"GlyCosmos","id":"P01193","properties":[{"key":"glycosylation","value":"2 sites, 8 glycans"}]},{"database":"GlyGen","id":"P01193","properties":[{"key":"glycosylation","value":"3 sites, 10 N-linked glycans (3 sites)"}]},{"database":"iPTMnet","id":"P01193","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P01193","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-4026","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000151504","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P01193","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"283426","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3452","properties":[{"key":"antibodies","value":"2442 antibodies from 45 providers"}]},{"database":"DNASU","id":"18976","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000020990.7","properties":[{"key":"ProteinId","value":"ENSMUSP00000020990.6"},{"key":"GeneId","value":"ENSMUSG00000020660.7"}]},{"database":"Ensembl","id":"ENSMUST00000218089.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000151367.2"},{"key":"GeneId","value":"ENSMUSG00000020660.7"}]},{"database":"Ensembl","id":"ENSMUST00000219543.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000151504.2"},{"key":"GeneId","value":"ENSMUSG00000020660.7"}]},{"database":"GeneID","id":"18976","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:18976","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007mxe.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:97742","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5443","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:97742","properties":[{"key":"GeneName","value":"Pomc"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000020660","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RZNY","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000016811","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_094632_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P01193","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NIRKYVM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8962839at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P01193","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-111885","properties":[{"key":"PathwayName","value":"Opioid Signalling"}]},{"database":"Reactome","id":"R-MMU-193048","properties":[{"key":"PathwayName","value":"Androgen biosynthesis"}]},{"database":"Reactome","id":"R-MMU-194002","properties":[{"key":"PathwayName","value":"Glucocorticoid biosynthesis"}]},{"database":"Reactome","id":"R-MMU-202040","properties":[{"key":"PathwayName","value":"G-protein activation"}]},{"database":"Reactome","id":"R-MMU-209952","properties":[{"key":"PathwayName","value":"Peptide hormone biosynthesis"}]},{"database":"Reactome","id":"R-MMU-211976","properties":[{"key":"PathwayName","value":"Endogenous sterols"}]},{"database":"Reactome","id":"R-MMU-375276","properties":[{"key":"PathwayName","value":"Peptide ligand-binding receptors"}]},{"database":"Reactome","id":"R-MMU-418555","properties":[{"key":"PathwayName","value":"G alpha (s) signalling events"}]},{"database":"Reactome","id":"R-MMU-418594","properties":[{"key":"PathwayName","value":"G alpha (i) signalling events"}]},{"database":"BioGRID-ORCS","id":"18976","properties":[{"key":"hits","value":"3 hits in 82 CRISPR screens"}]},{"database":"PRO","id":"PR:P01193","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"P01193","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000020660","properties":[{"key":"ExpressionPatterns","value":"Expressed in pituitary gland and 128 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P01193","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18388149"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16219686"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005782","properties":[{"key":"GoTerm","value":"C:peroxisomal matrix"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030141","properties":[{"key":"GoTerm","value":"C:secretory granule"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1329576"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16219686"}]},{"database":"GO","id":"GO:0001664","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005179","properties":[{"key":"GoTerm","value":"F:hormone activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15467755"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0070996","properties":[{"key":"GoTerm","value":"F:type 1 melanocortin receptor binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031781","properties":[{"key":"GoTerm","value":"F:type 3 melanocortin receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031782","properties":[{"key":"GoTerm","value":"F:type 4 melanocortin receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031783","properties":[{"key":"GoTerm","value":"F:type 5 melanocortin receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007189","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0061844","properties":[{"key":"GoTerm","value":"P:antimicrobial humoral immune response mediated by antimicrobial peptide"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25096581"}]},{"database":"GO","id":"GO:0007267","properties":[{"key":"GoTerm","value":"P:cell-cell signaling"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033059","properties":[{"key":"GoTerm","value":"P:cellular pigmentation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006091","properties":[{"key":"GoTerm","value":"P:generation of precursor metabolites and energy"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042593","properties":[{"key":"GoTerm","value":"P:glucose homeostasis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21184805"}]},{"database":"GO","id":"GO:0031640","properties":[{"key":"GoTerm","value":"P:killing of cells of another organism"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0035821","properties":[{"key":"GoTerm","value":"P:modulation of process of another organism"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0061744","properties":[{"key":"GoTerm","value":"P:motor behavior"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0032099","properties":[{"key":"GoTerm","value":"P:negative regulation of appetite"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:1903999","properties":[{"key":"GoTerm","value":"P:negative regulation of eating behavior"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0050777","properties":[{"key":"GoTerm","value":"P:negative regulation of immune response"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0002862","properties":[{"key":"GoTerm","value":"P:negative regulation of inflammatory response to antigenic stimulus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0032720","properties":[{"key":"GoTerm","value":"P:negative regulation of tumor necrosis factor production"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0106071","properties":[{"key":"GoTerm","value":"P:positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25096581"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031948","properties":[{"key":"GoTerm","value":"P:positive regulation of glucocorticoid biosynthetic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048023","properties":[{"key":"GoTerm","value":"P:positive regulation of melanin biosynthetic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0070965","properties":[{"key":"GoTerm","value":"P:positive regulation of neutrophil mediated killing of fungus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0140668","properties":[{"key":"GoTerm","value":"P:positive regulation of oxytocin production"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25096581"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032098","properties":[{"key":"GoTerm","value":"P:regulation of appetite"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008217","properties":[{"key":"GoTerm","value":"P:regulation of blood pressure"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"16243970"}]},{"database":"GO","id":"GO:2000852","properties":[{"key":"GoTerm","value":"P:regulation of corticosterone secretion"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21184805"}]},{"database":"GO","id":"GO:0060259","properties":[{"key":"GoTerm","value":"P:regulation of feeding behavior"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005981","properties":[{"key":"GoTerm","value":"P:regulation of glycogen catabolic process"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21184805"}]},{"database":"GO","id":"GO:1990680","properties":[{"key":"GoTerm","value":"P:response to melanocyte-stimulating hormone"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25096581"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR013531","properties":[{"key":"EntryName","value":"Mcrtin_ACTH_cent"}]},{"database":"InterPro","id":"IPR013593","properties":[{"key":"EntryName","value":"Melanocortin_N"}]},{"database":"InterPro","id":"IPR013532","properties":[{"key":"EntryName","value":"Opioid_neuropept"}]},{"database":"InterPro","id":"IPR001941","properties":[{"key":"EntryName","value":"PMOC"}]},{"database":"InterPro","id":"IPR050878","properties":[{"key":"EntryName","value":"POMC-derived_peptides"}]},{"database":"PANTHER","id":"PTHR11416","properties":[{"key":"EntryName","value":"PRO-OPIOMELANOCORTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11416:SF7","properties":[{"key":"EntryName","value":"PRO-OPIOMELANOCORTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00976","properties":[{"key":"EntryName","value":"ACTH_domain"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF08384","properties":[{"key":"EntryName","value":"NPP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08035","properties":[{"key":"EntryName","value":"Op_neuropeptide"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00383","properties":[{"key":"EntryName","value":"MELANOCORTIN"}]},{"database":"SMART","id":"SM01363","properties":[{"key":"EntryName","value":"ACTH_domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM01364","properties":[{"key":"EntryName","value":"NPP"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01365","properties":[{"key":"EntryName","value":"Op_neuropeptide"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACKLDLSLETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGSAAQRRAEEEAVWGDGSPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGERPLGLEQVLESDAEKDDGPYRVEHFRWSNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ","length":235,"molWeight":26707,"crc64":"EF98C0A95D6B4991","md5":"19FC9E719B286292FD7C1809D3D91542"},"extraAttributes":{"countByCommentType":{"FUNCTION":5,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Peptide":10,"Propeptide":1,"Region":2,"Compositional bias":3,"Modified residue":4,"Glycosylation":2,"Sequence conflict":1},"uniParcId":"UPI0000003F27"}}