{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P00934","secondaryAccessions":["Q6LEK8"],"uniProtkbId":"THRC_ECOLI","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"1986-07-21","entryVersion":193,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Threonine synthase"},"shortNames":[{"value":"TS"}],"ecNumbers":[{"value":"4.2.3.1"}]}},"genes":[{"geneName":{"value":"thrC"},"orderedLocusNames":[{"value":"b0004"},{"value":"JW0003"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7907888"}],"value":"Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L-serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"O-phospho-L-homoserine + H2O = L-threonine + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10840"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57590"},{"database":"ChEBI","id":"CHEBI:57926"}],"ecNumber":"4.2.3.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7907888"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7907888"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7907888"}],"value":"Is competitively inhibited by L-threo-3-hydroxyhomoserine phosphate"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":9.3,"unit":"umol/min/mg","enzyme":"enzyme","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7907888"}]}],"michaelisConstants":[{"constant":0.5,"unit":"mM","substrate":"O-phospho-L-homoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7907888"}]}]}},{"texts":[{"value":"Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the threonine synthase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"Threonine synthase","featureId":"PRO_0000185631"},{"type":"Modified residue","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Beta strand","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Turn","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Turn","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Turn","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":395,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Beta strand","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]},{"type":"Helix","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VB3"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0791","category":"Biological process","name":"Threonine biosynthesis"}],"references":[{"referenceNumber":1,"citation":{"id":"6316258","citationType":"journal article","authors":["Parsot C.","Cossart P.","Saint-Girons I.","Cohen G.N."],"citationCrossReferences":[{"database":"PubMed","id":"6316258"},{"database":"DOI","id":"10.1093/nar/11.21.7331"}],"title":"Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12.","publicationDate":"1983","journal":"Nucleic Acids Res.","firstPage":"7331","lastPage":"7345","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"1630901","citationType":"journal article","authors":["Yura T.","Mori H.","Nagai H.","Nagata T.","Ishihama A.","Fujita N.","Isono K.","Mizobuchi K.","Nakata A."],"citationCrossReferences":[{"database":"PubMed","id":"1630901"},{"database":"DOI","id":"10.1093/nar/20.13.3305"}],"title":"Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.","publicationDate":"1992","journal":"Nucleic Acids Res.","firstPage":"3305","lastPage":"3308","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"7610040","citationType":"journal article","authors":["Burland V.D.","Plunkett G. III","Sofia H.J.","Daniels D.L.","Blattner F.R."],"citationCrossReferences":[{"database":"PubMed","id":"7610040"},{"database":"DOI","id":"10.1093/nar/23.12.2105"}],"title":"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.","publicationDate":"1995","journal":"Nucleic Acids Res.","firstPage":"2105","lastPage":"2119","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"9298646","citationType":"journal article","authors":["Link A.J.","Robison K.","Church G.M."],"citationCrossReferences":[{"database":"PubMed","id":"9298646"},{"database":"DOI","id":"10.1002/elps.1150180807"}],"title":"Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.","publicationDate":"1997","journal":"Electrophoresis","firstPage":"1259","lastPage":"1313","volume":"18"},"referencePositions":["PROTEIN SEQUENCE OF 1-12"],"referenceComments":[{"value":"K12 / EMG2","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"9600841","citationType":"journal article","authors":["Wilkins M.R.","Gasteiger E.","Tonella L.","Ou K.","Tyler M.","Sanchez J.-C.","Gooley A.A.","Walsh B.J.","Bairoch A.","Appel R.D.","Williams K.L.","Hochstrasser D.F."],"citationCrossReferences":[{"database":"PubMed","id":"9600841"},{"database":"DOI","id":"10.1006/jmbi.1998.1726"}],"title":"Protein identification with N and C-terminal sequence tags in proteome projects.","publicationDate":"1998","journal":"J. Mol. Biol.","firstPage":"599","lastPage":"608","volume":"278"},"referencePositions":["PROTEIN SEQUENCE OF 1-4"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":8,"citation":{"id":"7907888","citationType":"journal article","authors":["Laber B.","Gerbling K.P.","Harde C.","Neff K.H.","Nordhoff E.","Pohlenz H.D."],"citationCrossReferences":[{"database":"PubMed","id":"7907888"},{"database":"DOI","id":"10.1021/bi00177a035"}],"title":"Mechanisms of interaction of Escherichia coli threonine synthase with substrates and inhibitors.","publicationDate":"1994","journal":"Biochemistry","firstPage":"3413","lastPage":"3423","volume":"33"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","COFACTOR","SUBSTRATE SPECIFICITY","ACTIVITY REGULATION","KINETIC PARAMETERS"]},{"referenceNumber":9,"citation":{"id":"CI-2ORFFGJUFL8TI","citationType":"submission","authors":["Omi R.","Goto M.","Miyahara I.","Mizuguchi H.","Hayashi H.","Kagamiyama H.","Hirotsu K."],"title":"Crystal structure of threonine synthase from Escherichia coli.","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U14003","properties":[{"key":"ProteinId","value":"AAA97303.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J01706","properties":[{"key":"ProteinId","value":"AAA83916.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC73115.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAB96581.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A01157","properties":[{"key":"EntryName","value":"SYECR"}]},{"database":"RefSeq","id":"NP_414545.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000781074.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"PDB","id":"1VB3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-428"}]},{"database":"PDBsum","id":"1VB3","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P00934","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P00934","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4261935","properties":[{"key":"Interactions","value":"248"}]},{"database":"BioGRID","id":"849584","properties":[{"key":"Interactions","value":"1"}]},{"database":"DIP","id":"DIP-10993N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P00934","properties":[{"key":"Number of interactors","value":"613"}]},{"database":"IntAct","id":"P00934","properties":[{"key":"Interactions","value":"4"}]},{"database":"STRING","id":"511145.b0004","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P00934","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b0004","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC73115","properties":[{"key":"ProteinId","value":"AAC73115"},{"key":"GeneId","value":"b0004"}]},{"database":"GeneID","id":"945198","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW0003","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b0004","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_00020","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.2279","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB0993","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG0498","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_015170_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P00934","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KGYLCEP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9763107at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P00934","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:THRESYN-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:THRESYN-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"4.2.3.1","properties":[{"key":"OrganismId","value":"2026"}]},{"database":"SABIO-RK","id":"P00934","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00050","properties":[{"key":"RectionId","value":"UER00065"}]},{"database":"EvolutionaryTrace","id":"P00934","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P00934","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P00934","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15911532"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18304323"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004795","properties":[{"key":"GoTerm","value":"F:threonine synthase activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6316258"}]},{"database":"GO","id":"GO:0009088","properties":[{"key":"GoTerm","value":"P:L-threonine biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"4148765"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"4364333"}]},{"database":"CDD","id":"cd01560","properties":[{"key":"EntryName","value":"Thr-synth_2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1100:FF:000026","properties":[{"key":"EntryName","value":"Threonine synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1380.10:FF:000001","properties":[{"key":"EntryName","value":"Threonine synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1100","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.1380.10","properties":[{"key":"EntryName","value":"Threonine synthase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000634","properties":[{"key":"EntryName","value":"Ser/Thr_deHydtase_PyrdxlP-BS"}]},{"database":"InterPro","id":"IPR029144","properties":[{"key":"EntryName","value":"Thr_synth_N"}]},{"database":"InterPro","id":"IPR037158","properties":[{"key":"EntryName","value":"Thr_synth_N_sf"}]},{"database":"InterPro","id":"IPR004450","properties":[{"key":"EntryName","value":"Thr_synthase-like"}]},{"database":"InterPro","id":"IPR051166","properties":[{"key":"EntryName","value":"Threonine_Synthase"}]},{"database":"InterPro","id":"IPR001926","properties":[{"key":"EntryName","value":"TrpB-like_PALP"}]},{"database":"InterPro","id":"IPR036052","properties":[{"key":"EntryName","value":"TrpB-like_PALP_sf"}]},{"database":"NCBIfam","id":"TIGR00260","properties":[{"key":"EntryName","value":"thrC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42690","properties":[{"key":"EntryName","value":"THREONINE SYNTHASE FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42690:SF1","properties":[{"key":"EntryName","value":"THREONINE SYNTHASE-LIKE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00291","properties":[{"key":"EntryName","value":"PALP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14821","properties":[{"key":"EntryName","value":"Thr_synth_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53686","properties":[{"key":"EntryName","value":"Tryptophan synthase beta subunit-like PLP-dependent enzymes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00165","properties":[{"key":"EntryName","value":"DEHYDRATASE_SER_THR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKLYNLKDHNEQVSFAQAVTQGLGKNQGLFFPHDLPEFSLTEIDEMLKLDFVTRSAKILSAFIGDEIPQEILEERVRAAFAFPAPVANVESDVGCLELFHGPTLAFKDFGGRFMAQMLTHIAGDKPVTILTATSGDTGAAVAHAFYGLPNVKVVILYPRGKISPLQEKLFCTLGGNIETVAIDGDFDACQALVKQAFDDEELKVALGLNSANSINISRLLAQICYYFEAVAQLPQETRNQLVVSVPSGNFGDLTAGLLAKSLGLPVKRFIAATNVNDTVPRFLHDGQWSPKATQATLSNAMDVSQPNNWPRVEELFRRKIWQLKELGYAAVDDETTQQTMRELKELGYTSEPHAAVAYRALRDQLNPGEYGLFLGTAHPAKFKESVEAILGETLDLPKELAERADLPLLSHNLPADFAALRKLMMNHQ","length":428,"molWeight":47114,"crc64":"5F7C20BE00B437E2","md5":"3FE5EE9BCEBD44132D18E2B50B8B92C3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"PATHWAY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Modified residue":1,"Beta strand":14,"Helix":27,"Turn":3},"uniParcId":"UPI0000136ED3"}}