{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P00722","secondaryAccessions":["Q2MC80"],"uniProtkbId":"BGAL_ECOLI","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":230,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Beta-galactosidase"},"shortNames":[{"value":"Beta-gal"}],"ecNumbers":[{"value":"3.2.1.23"}]},"alternativeNames":[{"fullName":{"value":"Lactase"}}]},"genes":[{"geneName":{"value":"lacZ"},"orderedLocusNames":[{"value":"b0344"},{"value":"JW0335"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.","ecNumber":"3.2.1.23"}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}},{"name":"Mn(2+)","cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}],"note":{"texts":[{"value":"Binds 2 magnesium ions per monomer. Can also use manganese."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Na(+)","cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29101"}}],"note":{"texts":[{"value":"Binds 1 sodium ion per monomer."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"}],"value":"Inhibited by phenylethyl thio-beta-D-galactoside (PETG), isopropyl thio-beta-D-galactoside (IPTG), L-ribose, D-galactonolactone, lactose and 2-amino-D-galactose"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":30.9,"unit":"umol/min/mg","enzyme":"enzyme with lactose as substrate (with magnesium as cofactor and 30 degrees Celsius)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"velocity":49.7,"unit":"umol/min/mg","enzyme":"enzyme with allolactose as substrate (with magnesium as cofactor and 30 degrees Celsius)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"velocity":59.7,"unit":"umol/min/mg","enzyme":"enzyme with p-nitrophenyl beta-D-galactoside as substrate (with magnesium as cofactor and 30 degrees Celsius)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"velocity":360.0,"unit":"umol/min/mg","enzyme":"enzyme with o-nitrophenyl beta-D-galactoside as substrate (with magnesium as cofactor and 30 degrees Celsius)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]}],"michaelisConstants":[{"constant":0.04,"unit":"mM","substrate":"p-nitrophenyl beta-D-galactoside","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"constant":0.12,"unit":"mM","substrate":"o-nitrophenyl beta-D-galactoside","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"constant":0.15,"unit":"mM","substrate":"2,3-dinitrophenyl beta-D-galactopyranoside","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"constant":0.41,"unit":"mM","substrate":"2,5-dinitrophenyl beta-D-galactopyranoside","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"constant":11.6,"unit":"mM","substrate":"p-nitrophenol-alpha-L-arabinopyranoside","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"constant":16.9,"unit":"mM","substrate":"p-nitrophenol-beta-D-fucopyranoside","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"constant":34.0,"unit":"uM","substrate":"p-nitrophenyl beta-D-galactoside (with magnesium as cofactor and 30 degrees Celsius)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"constant":140.0,"unit":"uM","substrate":"o-nitrophenyl beta-D-galactoside (with magnesium as cofactor and 30 degrees Celsius)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"constant":940.0,"unit":"uM","substrate":"allolactose (with magnesium as cofactor and 30 degrees Celsius)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]},{"constant":1350.0,"unit":"uM","substrate":"lactose (with magnesium as cofactor and 30 degrees Celsius)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"114210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}]}],"note":{"texts":[{"value":"The values for the enzymatic assays using manganese as cofactor are very close."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11045615"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11732897"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8008071"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P00722","intActId":"EBI-369998"},"interactantTwo":{"uniProtKBAccession":"P00722","geneName":"lacZ","intActId":"EBI-369998"},"numberOfExperiments":3,"organismDiffer":false}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"4562709"}],"value":"By allolactose"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the glycosyl hydrolase 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"97298"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":1024,"modifier":"EXACT"}},"description":"Beta-galactosidase","featureId":"PRO_0000057650"},{"type":"Active site","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6420154"}]},{"type":"Active site","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":538,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1350782"}]},{"type":"Binding site","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"","ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29101"}],"ligand":{"name":"Na(+)","id":"ChEBI:CHEBI:29101"}},{"type":"Binding site","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11045615"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11045615"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11045615"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"","ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"","ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":598,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11045615"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Binding site","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29101"}],"ligand":{"name":"Na(+)","id":"ChEBI:CHEBI:29101"}},{"type":"Binding site","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29101"}],"ligand":{"name":"Na(+)","id":"ChEBI:CHEBI:29101"}},{"type":"Binding site","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":1000,"modifier":"EXACT"},"end":{"value":1000,"modifier":"EXACT"}},"description":"","ligand":{"name":"substrate"}},{"type":"Site","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"Transition state stabilizer"},{"type":"Site","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"Transition state stabilizer"},{"type":"Site","location":{"start":{"value":1000,"modifier":"EXACT"},"end":{"value":1000,"modifier":"EXACT"}},"description":"Important for ensuring that an appropriate proportion of lactose is converted to allolactose"},{"type":"Mutagenesis","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Causes a significant decrease in binding affinity in the absence of monovalent cations or in the presence of potassium ions, but only a moderate decrease in the presence of sodium ions.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["E","N"]}},{"type":"Mutagenesis","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Obliterates all binding and catalysis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15060622"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"Less stable to heat than wild-type. Causes significant destabilizations of the first transition state.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9665715"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["D","F","L","N"]}},{"type":"Mutagenesis","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"Essentially inactive unless very rapid purification. Causes very large destabilizations of the transition state.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11310566"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["E","F","K"]}},{"type":"Mutagenesis","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"Slowly inactivates galactosidase activity by reducing the binding of magnesium. It increases binding specificity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7577931"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["H"]}},{"type":"Mutagenesis","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":538,"modifier":"EXACT"}},"description":"10000-fold decrease in the beta-galactosidase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11732897"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":541,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"Poorly reactive with galactosyl substrates. Less stable to heat than wild-type.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662937"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["E","F","N"]}},{"type":"Mutagenesis","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"Decreases the stability of the loop 794-804.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11732897"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":795,"modifier":"EXACT"},"end":{"value":795,"modifier":"EXACT"}},"description":"It forces the apoenzyme to adopt the closed rather than the open conformation. Reduces the binding affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14621996"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":798,"modifier":"EXACT"},"end":{"value":798,"modifier":"EXACT"}},"description":"The catalytic efficiency is not increased, when the sodium concentration increases.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17126292"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A","L"]}},{"type":"Mutagenesis","location":{"start":{"value":798,"modifier":"EXACT"},"end":{"value":798,"modifier":"EXACT"}},"description":"Small increase of the catalytic efficiency, when the sodium concentration increases.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17126292"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["D","Q"]}},{"type":"Mutagenesis","location":{"start":{"value":1000,"modifier":"EXACT"},"end":{"value":1000,"modifier":"EXACT"}},"description":"Decreases affinity for substrate.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12578395"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["F","G","L","T"]}},{"type":"Helix","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X1Q"}]},{"type":"Helix","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X1Q"}]},{"type":"Helix","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8Q7Y"}]},{"type":"Beta strand","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8BK8"}]},{"type":"Beta strand","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8BK8"}]},{"type":"Beta strand","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3J7H"}]},{"type":"Beta strand","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VD7"}]},{"type":"Beta strand","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3IAQ"}]},{"type":"Beta strand","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1JZ7"}]},{"type":"Helix","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1JYW"}]},{"type":"Helix","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1JZ7"}]},{"type":"Beta strand","location":{"start":{"value":498,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":507,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5A1A"}]},{"type":"Beta strand","location":{"start":{"value":514,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1JZ6"}]},{"type":"Helix","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":569,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":571,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7BRS"}]},{"type":"Beta strand","location":{"start":{"value":576,"modifier":"EXACT"},"end":{"value":579,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":581,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CVM"}]},{"type":"Beta strand","location":{"start":{"value":585,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":590,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":600,"modifier":"EXACT"},"end":{"value":603,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4V40"}]},{"type":"Turn","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4V40"}]},{"type":"Helix","location":{"start":{"value":617,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":627,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":652,"modifier":"EXACT"},"end":{"value":659,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":662,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":678,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1JZ8"}]},{"type":"Helix","location":{"start":{"value":687,"modifier":"EXACT"},"end":{"value":689,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1JYW"}]},{"type":"Beta strand","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":705,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":708,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":714,"modifier":"EXACT"},"end":{"value":726,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":735,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1JZ7"}]},{"type":"Beta strand","location":{"start":{"value":740,"modifier":"EXACT"},"end":{"value":743,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":745,"modifier":"EXACT"},"end":{"value":752,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":755,"modifier":"EXACT"},"end":{"value":760,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":761,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":765,"modifier":"EXACT"},"end":{"value":771,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":777,"modifier":"EXACT"},"end":{"value":784,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":790,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":794,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":799,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1PX4"}]},{"type":"Beta strand","location":{"start":{"value":804,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TSK"}]},{"type":"Helix","location":{"start":{"value":807,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":814,"modifier":"EXACT"},"end":{"value":818,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":820,"modifier":"EXACT"},"end":{"value":830,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":832,"modifier":"EXACT"},"end":{"value":847,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":849,"modifier":"EXACT"},"end":{"value":860,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Turn","location":{"start":{"value":861,"modifier":"EXACT"},"end":{"value":863,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1F4H"}]},{"type":"Beta strand","location":{"start":{"value":865,"modifier":"EXACT"},"end":{"value":873,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":875,"modifier":"EXACT"},"end":{"value":877,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5A1A"}]},{"type":"Helix","location":{"start":{"value":878,"modifier":"EXACT"},"end":{"value":880,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":881,"modifier":"EXACT"},"end":{"value":890,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":901,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":916,"modifier":"EXACT"},"end":{"value":922,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":923,"modifier":"EXACT"},"end":{"value":926,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":939,"modifier":"EXACT"},"end":{"value":947,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":950,"modifier":"EXACT"},"end":{"value":963,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":965,"modifier":"EXACT"},"end":{"value":970,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":974,"modifier":"EXACT"},"end":{"value":976,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":981,"modifier":"EXACT"},"end":{"value":991,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":999,"modifier":"EXACT"},"end":{"value":1001,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Helix","location":{"start":{"value":1006,"modifier":"EXACT"},"end":{"value":1008,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]},{"type":"Beta strand","location":{"start":{"value":1012,"modifier":"EXACT"},"end":{"value":1021,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8RI8"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0326","category":"Molecular function","name":"Glycosidase"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0464","category":"Ligand","name":"Manganese"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0915","category":"Ligand","name":"Sodium"}],"references":[{"referenceNumber":1,"citation":{"id":"6313347","citationType":"journal article","authors":["Kalnins A.","Otto K.","Ruether U.","Mueller-Hill B."],"citationCrossReferences":[{"database":"PubMed","id":"6313347"},{"database":"DOI","id":"10.1002/j.1460-2075.1983.tb01468.x"}],"title":"Sequence of the lacZ gene of Escherichia coli.","publicationDate":"1983","journal":"EMBO J.","firstPage":"593","lastPage":"597","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"CI-B1UJ6TNQ0SAS1","citationType":"submission","authors":["Chung E.","Allen E.","Araujo R.","Aparicio A.M.","Davis K.","Duncan M.","Federspiel N.","Hyman R.","Kalman S.","Komp C.","Kurdi O.","Lew H.","Lin D.","Namath A.","Oefner P.","Roberts D.","Schramm S.","Davis R.W."],"title":"Sequence of minutes 4-25 of Escherichia coli.","publicationDate":"JAN-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"97298","citationType":"journal article","authors":["Fowler A.V.","Zabin I."],"citationCrossReferences":[{"database":"PubMed","id":"97298"},{"database":"DOI","id":"10.1016/s0021-9258(17)30405-2"}],"title":"Amino acid sequence of beta-galactosidase. XI. Peptide ordering procedures and the complete sequence.","publicationDate":"1978","journal":"J. Biol. Chem.","firstPage":"5521","lastPage":"5525","volume":"253"},"referencePositions":["PROTEIN SEQUENCE OF 2-1024"]},{"referenceNumber":6,"citation":{"id":"6246435","citationType":"journal article","authors":["Calos M.P.","Miller J.H."],"citationCrossReferences":[{"database":"PubMed","id":"6246435"},{"database":"DOI","id":"10.1038/285038a0"}],"title":"Molecular consequences of deletion formation mediated by the transposon Tn9.","publicationDate":"1980","journal":"Nature","firstPage":"38","lastPage":"41","volume":"285"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 356-476"]},{"referenceNumber":7,"citation":{"id":"6444453","citationType":"journal article","authors":["Buechel D.E.","Gronenborn B.","Mueller-Hill B."],"citationCrossReferences":[{"database":"PubMed","id":"6444453"},{"database":"DOI","id":"10.1038/283541a0"}],"title":"Sequence of the lactose permease gene.","publicationDate":"1980","journal":"Nature","firstPage":"541","lastPage":"545","volume":"283"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1008-1024"]},{"referenceNumber":8,"citation":{"id":"4562709","citationType":"journal article","authors":["Jobe A.","Bourgeois S."],"citationCrossReferences":[{"database":"PubMed","id":"4562709"},{"database":"DOI","id":"10.1016/0022-2836(72)90253-7"}],"title":"lac repressor-operator interaction. VI. The natural inducer of the lac operon.","publicationDate":"1972","journal":"J. Mol. Biol.","firstPage":"397","lastPage":"408","volume":"69"},"referencePositions":["INDUCTION BY ALLOLACTOSE"]},{"referenceNumber":9,"citation":{"id":"114210","citationType":"journal article","authors":["Huber R.E.","Parfett C.","Woulfe-Flanagan H.","Thompson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"114210"},{"database":"DOI","id":"10.1021/bi00586a005"}],"title":"Interaction of divalent cations with beta-galactosidase (Escherichia coli).","publicationDate":"1979","journal":"Biochemistry","firstPage":"4090","lastPage":"4095","volume":"18"},"referencePositions":["BIOPHYSICOCHEMICAL PROPERTIES","COFACTOR"]},{"referenceNumber":10,"citation":{"id":"6411710","citationType":"journal article","authors":["Fowler A.V.","Smith P.J."],"citationCrossReferences":[{"database":"PubMed","id":"6411710"},{"database":"DOI","id":"10.1016/s0021-9258(17)44440-1"}],"title":"The active site regions of lacZ and ebg beta-galactosidases are homologous.","publicationDate":"1983","journal":"J. Biol. Chem.","firstPage":"10204","lastPage":"10207","volume":"258"},"referencePositions":["ACTIVE SITE REGIONS"]},{"referenceNumber":11,"citation":{"id":"6420154","citationType":"journal article","authors":["Herrchen M.","Legler G."],"citationCrossReferences":[{"database":"PubMed","id":"6420154"},{"database":"DOI","id":"10.1111/j.1432-1033.1984.tb07947.x"}],"title":"Identification of an essential carboxylate group at the active site of lacZ beta-galactosidase from Escherichia coli.","publicationDate":"1984","journal":"Eur. J. Biochem.","firstPage":"527","lastPage":"531","volume":"138"},"referencePositions":["ACTIVE SITE GLU-462"]},{"referenceNumber":12,"citation":{"id":"1350782","citationType":"journal article","authors":["Gebler J.C.","Aebersold R.","Withers S.G."],"citationCrossReferences":[{"database":"PubMed","id":"1350782"},{"database":"DOI","id":"10.1016/s0021-9258(19)49884-0"}],"title":"Glu-537, not Glu-461, is the nucleophile in the active site of (lac Z) beta-galactosidase from Escherichia coli.","publicationDate":"1992","journal":"J. Biol. Chem.","firstPage":"11126","lastPage":"11130","volume":"267"},"referencePositions":["ACTIVE SITE GLU-538"]},{"referenceNumber":13,"citation":{"id":"7577931","citationType":"journal article","authors":["Martinez-Bilbao M.","Gaunt M.T.","Huber R.E."],"citationCrossReferences":[{"database":"PubMed","id":"7577931"},{"database":"DOI","id":"10.1021/bi00041a022"}],"title":"E461H-beta-galactosidase (Escherichia coli): altered divalent metal specificity and slow but reversible metal inactivation.","publicationDate":"1995","journal":"Biochemistry","firstPage":"13437","lastPage":"13442","volume":"34"},"referencePositions":["MUTAGENESIS OF GLU-462","COFACTOR"]},{"referenceNumber":14,"citation":{"id":"8662937","citationType":"journal article","authors":["Roth N.J.","Huber R.E."],"citationCrossReferences":[{"database":"PubMed","id":"8662937"},{"database":"DOI","id":"10.1074/jbc.271.24.14296"}],"title":"The beta-galactosidase (Escherichia coli) reaction is partly facilitated by interactions of His-540 with the C6 hydroxyl of galactose.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"14296","lastPage":"14301","volume":"271"},"referencePositions":["BIOPHYSICOCHEMICAL PROPERTIES","MUTAGENESIS OF HIS-541"]},{"referenceNumber":15,"citation":{"id":"9298644","citationType":"journal article","authors":["VanBogelen R.A.","Abshire K.Z.","Moldover B.","Olson E.R.","Neidhardt F.C."],"citationCrossReferences":[{"database":"PubMed","id":"9298644"},{"database":"DOI","id":"10.1002/elps.1150180805"}],"title":"Escherichia coli proteome analysis using the gene-protein database.","publicationDate":"1997","journal":"Electrophoresis","firstPage":"1243","lastPage":"1251","volume":"18"},"referencePositions":["IDENTIFICATION BY 2D-GEL"]},{"referenceNumber":16,"citation":{"id":"9665715","citationType":"journal article","authors":["Roth N.J.","Rob B.","Huber R.E."],"citationCrossReferences":[{"database":"PubMed","id":"9665715"},{"database":"DOI","id":"10.1021/bi972796t"}],"title":"His-357 of beta-galactosidase (Escherichia coli) interacts with the C3 hydroxyl in the transition state and helps to mediate catalysis.","publicationDate":"1998","journal":"Biochemistry","firstPage":"10099","lastPage":"10107","volume":"37"},"referencePositions":["BIOPHYSICOCHEMICAL PROPERTIES","MUTAGENESIS OF HIS-358"]},{"referenceNumber":17,"citation":{"id":"11310566","citationType":"journal article","authors":["Huber R.E.","Hlede I.Y.","Roth N.J.","McKenzie K.C.","Ghumman K.K."],"citationCrossReferences":[{"database":"PubMed","id":"11310566"},{"database":"DOI","id":"10.1139/o00-101"}],"title":"His-391 of beta-galactosidase (Escherichia coli) promotes catalyses by strong interactions with the transition state.","publicationDate":"2001","journal":"Biochem. Cell Biol.","firstPage":"183","lastPage":"193","volume":"79"},"referencePositions":["MUTAGENESIS OF HIS-392"]},{"referenceNumber":18,"citation":{"id":"12578395","citationType":"journal article","authors":["Huber R.E.","Hakda S.","Cheng C.","Cupples C.G.","Edwards R.A."],"citationCrossReferences":[{"database":"PubMed","id":"12578395"},{"database":"DOI","id":"10.1021/bi0270642"}],"title":"Trp-999 of beta-galactosidase (Escherichia coli) is a key residue for binding, catalysis, and synthesis of allolactose, the natural lac operon inducer.","publicationDate":"2003","journal":"Biochemistry","firstPage":"1796","lastPage":"1803","volume":"42"},"referencePositions":["BIOPHYSICOCHEMICAL PROPERTIES","MUTAGENESIS OF TRP-1000"]},{"referenceNumber":19,"citation":{"id":"15060622","citationType":"journal article","authors":["Xu J.","McRae M.A.","Harron S.","Rob B.","Huber R.E."],"citationCrossReferences":[{"database":"PubMed","id":"15060622"},{"database":"DOI","id":"10.1139/o04-004"}],"title":"A study of the relationships of interactions between Asp-201, Na+ or K+, and galactosyl C6 hydroxyl and their effects on binding and reactivity of beta-galactosidase.","publicationDate":"2004","journal":"Biochem. Cell Biol.","firstPage":"275","lastPage":"284","volume":"82"},"referencePositions":["BIOPHYSICOCHEMICAL PROPERTIES","MUTAGENESIS OF ASP-202"]},{"referenceNumber":20,"citation":{"id":"15950161","citationType":"journal article","authors":["Matthews B.W."],"citationCrossReferences":[{"database":"PubMed","id":"15950161"},{"database":"DOI","id":"10.1016/j.crvi.2005.03.006"}],"title":"The structure of E. coli beta-galactosidase.","publicationDate":"2005","journal":"C. R. Biol.","firstPage":"549","lastPage":"556","volume":"328"},"referencePositions":["REVIEW"]},{"referenceNumber":21,"citation":{"id":"17126292","citationType":"journal article","authors":["Sutendra G.","Wong S.","Fraser M.E.","Huber R.E."],"citationCrossReferences":[{"database":"PubMed","id":"17126292"},{"database":"DOI","id":"10.1016/j.bbrc.2006.11.061"}],"title":"Beta-galactosidase (Escherichia coli) has a second catalytically important Mg2+ site.","publicationDate":"2007","journal":"Biochem. Biophys. Res. Commun.","firstPage":"566","lastPage":"570","volume":"352"},"referencePositions":["COFACTOR","MUTAGENESIS OF GLU-798"]},{"referenceNumber":22,"citation":{"id":"8008071","citationType":"journal article","authors":["Jacobson R.H.","Zhang X.-J.","Dubose R.F.","Matthews B.W."],"citationCrossReferences":[{"database":"PubMed","id":"8008071"},{"database":"DOI","id":"10.1038/369761a0"}],"title":"Three-dimensional structure of beta-galactosidase from E. coli.","publicationDate":"1994","journal":"Nature","firstPage":"761","lastPage":"766","volume":"369"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) IN COMPLEX WITH MAGNESIUM IONS","SUBUNIT"]},{"referenceNumber":23,"citation":{"id":"11045615","citationType":"journal article","authors":["Juers D.H.","Jacobson R.H.","Wigley D.","Zhang X.-J.","Huber R.E.","Tronrud D.E.","Matthews B.W."],"citationCrossReferences":[{"database":"PubMed","id":"11045615"},{"database":"DOI","id":"10.1110/ps.9.9.1685"}],"title":"High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for alpha-complementation.","publicationDate":"2000","journal":"Protein Sci.","firstPage":"1685","lastPage":"1699","volume":"9"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH MAGNESIUM AND SODIUM IONS"]},{"referenceNumber":24,"citation":{"id":"11732897","citationType":"journal article","authors":["Juers D.H.","Heightman T.D.","Vasella A.","McCarter J.D.","Mackenzie L.","Withers S.G.","Matthews B.W."],"citationCrossReferences":[{"database":"PubMed","id":"11732897"},{"database":"DOI","id":"10.1021/bi011727i"}],"title":"A structural view of the action of Escherichia coli (lacZ) beta-galactosidase.","publicationDate":"2001","journal":"Biochemistry","firstPage":"14781","lastPage":"14794","volume":"40"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOGS","MUTAGENESIS OF GLU-538 AND PHE-602","REACTION MECHANISM"]},{"referenceNumber":25,"citation":{"id":"14621996","citationType":"journal article","authors":["Juers D.H.","Hakda S.","Matthews B.W.","Huber R.E."],"citationCrossReferences":[{"database":"PubMed","id":"14621996"},{"database":"DOI","id":"10.1021/bi035506j"}],"title":"Structural basis for the altered activity of Gly794 variants of Escherichia coli beta-galactosidase.","publicationDate":"2003","journal":"Biochemistry","firstPage":"13505","lastPage":"13511","volume":"42"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 10-1024 OF MUTANT ALA-795 IN COMPLEX WITH MAGNESIUM IONS","SODIUM IONS AND SUBSTRATE ANALOGS","BIOPHYSICOCHEMICAL PROPERTIES","ACTIVITY REGULATION","MUTAGENESIS OF GLY-795"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"J01636","properties":[{"key":"ProteinId","value":"AAA24053.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"V00296","properties":[{"key":"ProteinId","value":"CAA23573.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U73857","properties":[{"key":"ProteinId","value":"AAB18068.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC73447.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE76126.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"V00295","properties":[{"key":"ProteinId","value":"CAA23570.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A90981","properties":[{"key":"EntryName","value":"GBEC"}]},{"database":"RefSeq","id":"NP_414878.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000177906.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP010441.1"}]},{"database":"PDB","id":"1DP0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1F4A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B/C/D=4-1024"}]},{"database":"PDB","id":"1F4H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B/C/D=4-1024"}]},{"database":"PDB","id":"1HN1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JYN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JYV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JYW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JYX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JZ2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=2-1024"}]},{"database":"PDB","id":"1JZ3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JZ4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JZ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JZ6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JZ7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1JZ8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1PX3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"1PX4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3CZJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3DYM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3DYO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3DYP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3E1F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"1/2/3/4=10-1024"}]},{"database":"PDB","id":"3I3B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3I3D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3I3E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3IAP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3IAQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3J7H","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"3MUY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"1/2/3/4=10-1024"}]},{"database":"PDB","id":"3MUZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"1/2/3/4=10-1024"}]},{"database":"PDB","id":"3MV0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"1/2/3/4=10-1024"}]},{"database":"PDB","id":"3MV1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"1/2/3/4=10-1024"}]},{"database":"PDB","id":"3SEP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3T08","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3T09","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3T0A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3T0B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3T0D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.93 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3T2O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3T2P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3T2Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3VD3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3VD4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3VD5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3VD7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.87 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3VD9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3VDA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3VDB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"3VDC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"4CKD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"13.00 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"4DUV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"4DUW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"4DUX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"4TTG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B/C/D=15-1024"}]},{"database":"PDB","id":"4V40","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-1024"}]},{"database":"PDB","id":"4V41","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-1024"}]},{"database":"PDB","id":"4V44","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-1024"}]},{"database":"PDB","id":"4V45","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-1024"}]},{"database":"PDB","id":"5A1A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D=3-1024"}]},{"database":"PDB","id":"6CVM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D=3-1023"}]},{"database":"PDB","id":"6DRV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"6KUZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.83 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"6TSH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"6TSK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"6TTE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D=10-1024"}]},{"database":"PDB","id":"6X1Q","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D=3-1023"}]},{"database":"PDB","id":"7BRS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.67 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"7BTK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"8BK7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"8BK8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"8BKG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"8Q7Y","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"8RI6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.06 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"8RI7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.93 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"8RI8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.42 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"8VT0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.58 A"},{"key":"Chains","value":"A/B/C/D=3-1024"}]},{"database":"PDB","id":"9HKI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D=3-1023"}]},{"database":"PDB","id":"9HLM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"A/B/C/D=3-1023"}]},{"database":"PDB","id":"9HPL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"9HPM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDB","id":"9Y45","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.41 A"},{"key":"Chains","value":"A/B/C/D=1-1024"}]},{"database":"PDBsum","id":"1DP0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1F4A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1F4H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1HN1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JYN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JYV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JYW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JYX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JZ2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JZ3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JZ4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JZ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JZ6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JZ7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JZ8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1PX3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1PX4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3CZJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3DYM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3DYO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3DYP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3E1F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3I3B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3I3D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3I3E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3IAP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3IAQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3J7H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3MUY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3MUZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3MV0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3MV1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3SEP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3T08","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3T09","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3T0A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3T0B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3T0D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3T2O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3T2P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3T2Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3VD3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3VD4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3VD5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3VD7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3VD9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3VDA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3VDB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3VDC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CKD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DUV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DUW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DUX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4TTG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4V40","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4V41","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4V44","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4V45","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5A1A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CVM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6DRV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KUZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TSH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TSK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TTE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X1Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7BRS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7BTK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8BK7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8BK8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8BKG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Q7Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RI6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RI7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RI8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VT0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HKI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HLM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HPL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HPM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Y45","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16091","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16092","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16097","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-18244","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-19181","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-19182","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-19183","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21995","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-2548","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-2824","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-2984","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31313","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51069","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51071","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51072","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51415","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51440","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52230","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52260","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52333","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52334","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-5995","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70549","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70551","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70552","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-72471","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7770","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-8908","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"PCDDB","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4263186","properties":[{"key":"Interactions","value":"82"}]},{"database":"BioGRID","id":"849400","properties":[{"key":"Interactions","value":"1"}]},{"database":"DIP","id":"DIP-10081N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P00722","properties":[{"key":"Number of interactors","value":"490"}]},{"database":"IntAct","id":"P00722","properties":[{"key":"Interactions","value":"76"}]},{"database":"STRING","id":"511145.b0344","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4603","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB02294","properties":[{"key":"GenericName","value":"(5R,6S,7S,8S)-5-hydroxymethyl-6,7,8-trihydroxy-tetrazolo[1,5-A]piperidine"}]},{"database":"DrugBank","id":"DB01920","properties":[{"key":"GenericName","value":"1-O-[O-Nitrophenyl]-Beta-D-Galactopyranose"}]},{"database":"DrugBank","id":"DB02228","properties":[{"key":"GenericName","value":"2-deoxy-2-fluoro-Beta-D-galactose"}]},{"database":"DrugBank","id":"DB04382","properties":[{"key":"GenericName","value":"2-Deoxy-alpha-D-galactopyranose"}]},{"database":"DrugBank","id":"DB04155","properties":[{"key":"GenericName","value":"2-Fluoro-2-Deoxy-Beta-D-Galactopyranosyl-Beta-D-Glucopyranose"}]},{"database":"DrugBank","id":"DB02632","properties":[{"key":"GenericName","value":"4-nitrophenyl-beta-D-galactoside"}]},{"database":"DrugBank","id":"DB04116","properties":[{"key":"GenericName","value":"Allolactose"}]},{"database":"DrugBank","id":"DB01885","properties":[{"key":"GenericName","value":"D-Galctopyranosyl-1-On"}]},{"database":"DrugBank","id":"DB01862","properties":[{"key":"GenericName","value":"Isopropyl beta-D-thiogalactopyranoside"}]},{"database":"DrugBank","id":"DB04465","properties":[{"key":"GenericName","value":"Lactose"}]},{"database":"DrugBank","id":"DB04530","properties":[{"key":"GenericName","value":"S,S-(2-Hydroxyethyl)Thiocysteine"}]},{"database":"DrugBank","id":"DB13503","properties":[{"key":"GenericName","value":"Tyrothricin"}]},{"database":"CAZy","id":"GH2","properties":[{"key":"FamilyName","value":"Glycoside Hydrolase Family 2"}]},{"database":"PaxDb","id":"511145-b0344","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P00722","properties":[{"key":"antibodies","value":"6 sequenced antibodies"}]},{"database":"EnsemblBacteria","id":"AAC73447","properties":[{"key":"ProteinId","value":"AAC73447"},{"key":"GeneId","value":"b0344"}]},{"database":"GeneID","id":"945006","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW0335","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b0344","properties":[{"key":"Description","value":"-"}]},{"database":"EchoBASE","id":"EB0522","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG3250","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_002346_0_2_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WASAMLD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9758603at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:BETAGALACTOSID-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:BETAGALACTOSID-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.2.1.23","properties":[{"key":"OrganismId","value":"2026"}]},{"database":"SABIO-RK","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"PHI-base","id":"PHI:6268","properties":[{"key":"Description","value":"-"}]},{"database":"PHI-base","id":"PHI:9897","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P00722","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P00722","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009341","properties":[{"key":"GoTerm","value":"C:beta-galactosidase complex"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14304855"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8008071"}]},{"database":"GO","id":"GO:0031420","properties":[{"key":"GoTerm","value":"F:alkali metal ion binding"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11732897"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"4860414"}]},{"database":"GO","id":"GO:0004565","properties":[{"key":"GoTerm","value":"F:beta-galactosidase activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14304855"}]},{"database":"GO","id":"GO:0030246","properties":[{"key":"GoTerm","value":"F:carbohydrate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23850452"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24613486"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25953817"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11045615"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"4625429"}]},{"database":"GO","id":"GO:0005990","properties":[{"key":"GoTerm","value":"P:lactose catabolic process"},{"key":"GoEvidenceType","value":"IMP:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22475386"}]},{"database":"FunFam","id":"2.60.120.260:FF:000058","properties":[{"key":"EntryName","value":"Beta-galactosidase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000680","properties":[{"key":"EntryName","value":"Beta-galactosidase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000850","properties":[{"key":"EntryName","value":"Beta-galactosidase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.98.10:FF:000006","properties":[{"key":"EntryName","value":"Beta-galactosidase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.80:FF:000018","properties":[{"key":"EntryName","value":"Beta-galactosidase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.98.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.260","properties":[{"key":"EntryName","value":"Galactose-binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.80","properties":[{"key":"EntryName","value":"Glycosidases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_01687","properties":[{"key":"EntryName","value":"Beta_gal"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004199","properties":[{"key":"EntryName","value":"B-gal_small/dom_5"}]},{"database":"InterPro","id":"IPR050347","properties":[{"key":"EntryName","value":"Bact_Beta-galactosidase"}]},{"database":"InterPro","id":"IPR036156","properties":[{"key":"EntryName","value":"Beta-gal/glucu_dom_sf"}]},{"database":"InterPro","id":"IPR011013","properties":[{"key":"EntryName","value":"Gal_mutarotase_sf_dom"}]},{"database":"InterPro","id":"IPR008979","properties":[{"key":"EntryName","value":"Galactose-bd-like_sf"}]},{"database":"InterPro","id":"IPR014718","properties":[{"key":"EntryName","value":"GH-type_carb-bd"}]},{"database":"InterPro","id":"IPR017853","properties":[{"key":"EntryName","value":"GH_hydrolase_sf"}]},{"database":"InterPro","id":"IPR006101","properties":[{"key":"EntryName","value":"Glyco_hydro_2"}]},{"database":"InterPro","id":"IPR023232","properties":[{"key":"EntryName","value":"Glyco_hydro_2_AS"}]},{"database":"InterPro","id":"IPR023933","properties":[{"key":"EntryName","value":"Glyco_hydro_2_beta_Galsidase"}]},{"database":"InterPro","id":"IPR006103","properties":[{"key":"EntryName","value":"Glyco_hydro_2_cat"}]},{"database":"InterPro","id":"IPR023230","properties":[{"key":"EntryName","value":"Glyco_hydro_2_CS"}]},{"database":"InterPro","id":"IPR006104","properties":[{"key":"EntryName","value":"Glyco_hydro_2_N"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR006102","properties":[{"key":"EntryName","value":"Ig-like_GH2"}]},{"database":"InterPro","id":"IPR032312","properties":[{"key":"EntryName","value":"LacZ_4"}]},{"database":"NCBIfam","id":"NF007074","properties":[{"key":"EntryName","value":"PRK09525.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46323","properties":[{"key":"EntryName","value":"BETA-GALACTOSIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46323:SF2","properties":[{"key":"EntryName","value":"BETA-GALACTOSIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02929","properties":[{"key":"EntryName","value":"Bgal_small_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00703","properties":[{"key":"EntryName","value":"Glyco_hydro_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02836","properties":[{"key":"EntryName","value":"Glyco_hydro_2_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02837","properties":[{"key":"EntryName","value":"Glyco_hydro_2_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16353","properties":[{"key":"EntryName","value":"LacZ_4"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00132","properties":[{"key":"EntryName","value":"GLHYDRLASE2"}]},{"database":"SMART","id":"SM01038","properties":[{"key":"EntryName","value":"Bgal_small_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51445","properties":[{"key":"EntryName","value":"(Trans)glycosidases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49303","properties":[{"key":"EntryName","value":"beta-Galactosidase/glucuronidase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF74650","properties":[{"key":"EntryName","value":"Galactose mutarotase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49785","properties":[{"key":"EntryName","value":"Galactose-binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00719","properties":[{"key":"EntryName","value":"GLYCOSYL_HYDROL_F2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00608","properties":[{"key":"EntryName","value":"GLYCOSYL_HYDROL_F2_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTMITDSLAVVLQRRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWRFAWFPAPEAVPESWLECDLPEADTVVVPSNWQMHGYDAPIYTNVTYPITVNPPFVPTENPTGCYSLTFNVDESWLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFDLSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIFRDVSLLHKPTTQISDFHVATRFNDDFSRAVLEAEVQMCGELRDYLRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLRLNVENPKLWSAEIPNLYRAVVELHTADGTLIEAEACDVGFREVRIENGLLLLNGKPLLIRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPMNRLTDDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGETRPLILCEYAHAMGNSLGGFAKYWQAFRQYPRLQGGFVWDWVDQSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRTPHPALTEAKHQQQFFQFRLSGQTIEVTSEYLFRHSDNELLHWMVALDGKPLASGEVPLDVAPQGKQLIELPELPQPESAGQLWLTVRVVQPNATAWSEAGHISAWQQWRLAENLSVTLPAASHAIPHLTTSEMDFCIELGNKRWQFNRQSGFLSQMWIGDKKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKAAGHYQAEAALLQCTADTLADAVLITTAHAWQHQGKTLFISRKTYRIDGSGQMAITVDVEVASDTPHPARIGLNCQLAQVAERVNWLGLGPQENYPDRLTAACFDRWDLPLSDMYTPYVFPSENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSHRHLLHAEEGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAGRYHYQLVWCQK","length":1024,"molWeight":116483,"crc64":"9D295EF4CEF90B08","md5":"61D924523CD4BD0DBAB1985E54F1F401"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBUNIT":1,"INTERACTION":1,"INDUCTION":1,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Active site":2,"Binding site":13,"Site":3,"Mutagenesis":12,"Helix":34,"Turn":12,"Beta strand":73},"uniParcId":"UPI0000049419"}}