{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P00441","secondaryAccessions":["A6NHJ0","D3DSE4","Q16669","Q16711","Q16838","Q16839","Q16840","Q6NR85"],"uniProtkbId":"SODC_HUMAN","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-01-23","entryVersion":280,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Superoxide dismutase [Cu-Zn]"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24140062"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18948262"}],"value":"1.15.1.1"},{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"1.8.-.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"36630448"}],"value":"Hydrogen sulfide oxidase"}},{"fullName":{"value":"Superoxide dismutase 1"},"shortNames":[{"value":"hSod1"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:11179"}],"value":"SOD1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18948262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24140062"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36630448"}],"value":"Destroys radicals which are normally produced within the cells and which are toxic to biological systems (PubMed:18948262, PubMed:24140062). Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides (PubMed:36630448)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 superoxide + 2 H(+) = H2O2 + O2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20696"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16240"},{"database":"ChEBI","id":"CHEBI:18421"}],"ecNumber":"1.15.1.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24140062"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18948262"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hydrogen sulfide + 2 O2 = sulfate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85007"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16189"},{"database":"ChEBI","id":"CHEBI:29919"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36630448"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:85008"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"36630448"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Cu cation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17888947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36630448"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:23378"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17888947"}],"value":"Binds 1 copper ion per subunit."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17888947"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17888947"}],"value":"Binds 1 zinc ion per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18948262"}],"value":"Activated by CCS/copper chaperone for superoxide dismutase; can also be activated independently of CCS"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08228"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10329151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12911296"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15326189"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16291742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16406071"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17548825"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17888947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20600836"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20727846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30037290"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31292775"}],"value":"Homodimer; non-disulfide-linked (By similarity). Homodimerization may take place via the ditryptophan cross-link at Trp-33. Heterodimer with CCS (PubMed:31292775). The heterodimer CCS:SOD1 interacts with SLC31A1; this heterotrimer is Cu(1+)-mediated and its maintenance is regulated through SOD1 activation (PubMed:31292775). Interacts with DAOA; the interaction is direct (PubMed:30037290)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P13928","geneName":"ANXA8","intActId":"EBI-2556915"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P63010-2","geneName":"AP2B1","intActId":"EBI-11529439"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q0P5N6","geneName":"ARL16","intActId":"EBI-10186132"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q16611","geneName":"BAK1","intActId":"EBI-519866"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P10415","geneName":"BCL2","intActId":"EBI-77694"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9BXK5","geneName":"BCL2L13","intActId":"EBI-747430"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q5SZD1","geneName":"C6orf141","intActId":"EBI-10697767"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P02748","geneName":"C9","intActId":"EBI-6677628"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8N5S9-2","geneName":"CAMKK1","intActId":"EBI-25850646"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q13191","geneName":"CBLB","intActId":"EBI-744027"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"O14618","geneName":"CCS","intActId":"EBI-11668690"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P53672","geneName":"CRYBA2","intActId":"EBI-750444"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P48730-2","geneName":"CSNK1D","intActId":"EBI-9087876"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P98082","geneName":"DAB2","intActId":"EBI-1171238"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8TCX1","geneName":"DYNC2LI1","intActId":"EBI-8568003"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P29692","geneName":"EEF1D","intActId":"EBI-358607"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8TC29","geneName":"ENKUR","intActId":"EBI-9246952"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P02671-2","geneName":"FGA","intActId":"EBI-9640259"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8WW76","geneName":"FGA","intActId":"EBI-16467458"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"F2Z2M7","geneName":"GALNT10","intActId":"EBI-23893155"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P04406","geneName":"GAPDH","intActId":"EBI-354056"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P62879","geneName":"GNB2","intActId":"EBI-356942"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9Y4H4","geneName":"GPSM3","intActId":"EBI-347538"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8WVV9-3","geneName":"HNRNPLL","intActId":"EBI-25845242"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P09017","geneName":"HOXC4","intActId":"EBI-3923226"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P80217-2","geneName":"IFI35","intActId":"EBI-12823003"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q6DN90-2","geneName":"IQSEC1","intActId":"EBI-21911304"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"O14713","geneName":"ITGB1BP1","intActId":"EBI-2127319"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q15046","geneName":"KARS1","intActId":"EBI-356367"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9NVX7-2","geneName":"KBTBD4","intActId":"EBI-25871195"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8N4N3-2","geneName":"KLHL36","intActId":"EBI-10973851"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q96JM7-2","geneName":"L3MBTL3","intActId":"EBI-11985629"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9BYZ2","geneName":"LDHAL6B","intActId":"EBI-1108377"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"O95777","geneName":"LSM8","intActId":"EBI-347779"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8TDB4","geneName":"MGARP","intActId":"EBI-4397720"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"A4FUJ8","geneName":"MKL1","intActId":"EBI-21250407"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8N594","geneName":"MPND","intActId":"EBI-2512452"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q96FW1","geneName":"OTUB1","intActId":"EBI-1058491"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q6GQQ9-2","geneName":"OTUD7B","intActId":"EBI-25830200"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9BYU1","geneName":"PBX4","intActId":"EBI-10302990"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q13113","geneName":"PDZK1IP1","intActId":"EBI-716063"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q08209-2","geneName":"PPP3CA","intActId":"EBI-11959013"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P30044","geneName":"PRDX5","intActId":"EBI-722161"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P28062-2","geneName":"PSMB8","intActId":"EBI-372312"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P62191","geneName":"PSMC1","intActId":"EBI-357598"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P17980","geneName":"PSMC3","intActId":"EBI-359720"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P43686-2","geneName":"PSMC4","intActId":"EBI-21522939"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q09028","geneName":"RBBP4","intActId":"EBI-620823"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q6ZNA4-2","geneName":"RNF111","intActId":"EBI-21535400"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9ULX5","geneName":"RNF112","intActId":"EBI-25829984"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9NV58","geneName":"RNF19A","intActId":"EBI-1390270"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9BUL9","geneName":"RPP25","intActId":"EBI-366570"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P08865","geneName":"RPSA","intActId":"EBI-354112"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8N488","geneName":"RYBP","intActId":"EBI-752324"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P60896","geneName":"SEM1","intActId":"EBI-79819"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q15393","geneName":"SF3B3","intActId":"EBI-346977"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q2NKQ1-4","geneName":"SGSM1","intActId":"EBI-10182463"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9GZS3","geneName":"SKIC8","intActId":"EBI-358545"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P37840","geneName":"SNCA","intActId":"EBI-985879"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P00441","geneName":"SOD1","intActId":"EBI-990792"},"numberOfExperiments":22,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q3SY56","geneName":"SP6","intActId":"EBI-11175533"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8NHS9","geneName":"SPATA22","intActId":"EBI-7067260"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q96MF2","geneName":"STAC3","intActId":"EBI-745680"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q92797-2","geneName":"SYMPK","intActId":"EBI-21560407"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9BZK7","geneName":"TBL1XR1","intActId":"EBI-765729"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q15554-4","geneName":"TERF2","intActId":"EBI-25840535"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q9H3N1","geneName":"TMX1","intActId":"EBI-1051115"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q13829","geneName":"TNFAIP1","intActId":"EBI-2505861"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P07951-2","geneName":"TPM2","intActId":"EBI-10977815"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P07437","geneName":"TUBB","intActId":"EBI-350864"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P0CG47","geneName":"UBB","intActId":"EBI-413034"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"O75604-3","geneName":"USP2","intActId":"EBI-10696113"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q96NC0","geneName":"ZMAT2","intActId":"EBI-2682299"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"O95789-4","geneName":"ZMYM6","intActId":"EBI-12949277"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q8NBB4-2","geneName":"ZSCAN1","intActId":"EBI-12021938"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"Q2QGD7","geneName":"ZXDC","intActId":"EBI-1538838"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P26339","geneName":"Chga","intActId":"EBI-990900"},"numberOfExperiments":5,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P16014","geneName":"Chgb","intActId":"EBI-990820"},"numberOfExperiments":6,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P01041","geneName":"Cstb","intActId":"EBI-26602017"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P00441","intActId":"EBI-990792"},"interactantTwo":{"uniProtKBAccession":"P20029","geneName":"Hspa5","intActId":"EBI-772325"},"numberOfExperiments":7,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19741096"}],"value":"Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19741096"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22496122"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19741096"}],"value":"Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20600836"}],"value":"The ditryptophan cross-link at Trp-33 is responsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22496122"}],"value":"Palmitoylation helps nuclear targeting and decreases catalytic activity"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24140062"}],"value":"Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Amyotrophic lateral sclerosis 1","diseaseAccession":"DI-00108","acronym":"ALS1","description":"A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.","diseaseCrossReference":{"database":"MIM","id":"105400"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10430435"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10732812"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11369193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11535232"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12210393"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12402272"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754496"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15056757"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18301754"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18378676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19741096"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20460594"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21220647"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21247266"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24283821"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27604643"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31086828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7496169"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7501156"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7647793"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7655468"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7655469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7655471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7700376"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7795609"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7836951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7870076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7881433"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7951252"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7980516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7997024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8069312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8179602"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8528216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8682505"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8875253"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8907321"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8938700"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8990014"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9101297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9131652"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9365366"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9455977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9541385"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9696308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9706719"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.86"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Spastic tetraplegia and axial hypotonia, progressive","diseaseAccession":"DI-05666","acronym":"STAHP","description":"An autosomal recessive, neurologic disorder characterized by loss of motor abilities in the first year of life, after which severe, progressive spastic tetraparesis develops. Affected individuals have severe axial hypotonia, hyperekplexia, hypertonia, and myokymia, reflecting upper motor neuron involvement. Cognitive development may be affected.","diseaseCrossReference":{"database":"MIM","id":"618598"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31314961"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31332433"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"value":"The protein (both wild-type and ALS1 variants) has a tendency to form fibrillar aggregates in the absence of the intramolecular disulfide bond or of bound zinc ions. These aggregates may have cytotoxic effects. Zinc binding promotes dimerization and stabilizes the native form"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Cu-Zn superoxide dismutase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAC41773.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"CAA25917.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Alsod","resourceUrl":"https://alsod.ac.uk","ftp":false,"note":"ALS genetic mutations db"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Superoxide_dismutase","ftp":false,"note":"Superoxide dismutase entry"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6770891"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7002610"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25944712"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Superoxide dismutase [Cu-Zn]","featureId":"PRO_0000164057"},{"type":"Binding site","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:23378"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17548825"}],"ligand":{"name":"Cu cation","id":"ChEBI:CHEBI:23378","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:23378"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17548825"}],"ligand":{"name":"Cu cation","id":"ChEBI:CHEBI:23378","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:23378"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17548825"}],"ligand":{"name":"Cu cation","id":"ChEBI:CHEBI:23378","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20727846"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"structural"}},{"type":"Binding site","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20727846"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"structural"}},{"type":"Binding site","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20727846"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"structural"}},{"type":"Binding site","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20727846"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"structural"}},{"type":"Binding site","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:23378"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17548825"}],"ligand":{"name":"Cu cation","id":"ChEBI:CHEBI:23378","note":"catalytic"}},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1463506"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7002610"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25944712"}]},{"type":"Modified residue","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"N6-succinyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08228"}]},{"type":"Modified residue","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"N6-succinyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08228"}]},{"type":"Modified residue","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"N6-succinyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08228"}]},{"type":"Modified residue","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07632"}]},{"type":"Modified residue","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08228"}]},{"type":"Modified residue","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24140062"}]},{"type":"Modified residue","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08228"}]},{"type":"Modified residue","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08228"}]},{"type":"Lipidation","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22496122"}]},{"type":"Disulfide bond","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1463506"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15326189"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16406071"}]},{"type":"Cross-link","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20600836"}]},{"type":"Natural variant","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912444","featureCrossReferences":[{"database":"dbSNP","id":"rs121912444"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9696308"}],"featureId":"VAR_013518","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912444","featureCrossReferences":[{"database":"dbSNP","id":"rs121912444"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8179602"}],"featureId":"VAR_007130","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"in ALS1; severe form; reduces structural stability and enzyme activity; increases tendency to form fibrillar aggregates; dbSNP:rs121912442","featureCrossReferences":[{"database":"dbSNP","id":"rs121912442"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15056757"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9365366"}],"featureId":"VAR_007131","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912448","featureCrossReferences":[{"database":"dbSNP","id":"rs121912448"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8907321"}],"featureId":"VAR_008717","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568807330","featureCrossReferences":[{"database":"dbSNP","id":"rs1568807330"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7980516"}],"featureId":"VAR_007132","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568807342","featureCrossReferences":[{"database":"dbSNP","id":"rs1568807342"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9131652"}],"featureId":"VAR_013519","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568807333","featureCrossReferences":[{"database":"dbSNP","id":"rs1568807333"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_013520","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912456","featureCrossReferences":[{"database":"dbSNP","id":"rs121912456"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10430435"}],"featureId":"VAR_013521","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1202989817","featureCrossReferences":[{"database":"dbSNP","id":"rs1202989817"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9365366"}],"featureId":"VAR_013522","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568807400","featureCrossReferences":[{"database":"dbSNP","id":"rs1568807400"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7655471"}],"featureId":"VAR_007133","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"in ALS1; sporadic young onset; dbSNP:rs121912453","featureCrossReferences":[{"database":"dbSNP","id":"rs121912453"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9101297"}],"featureId":"VAR_007134","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1555836169","featureCrossReferences":[{"database":"dbSNP","id":"rs1555836169"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_045876","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568807435","featureCrossReferences":[{"database":"dbSNP","id":"rs1568807435"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9706719"}],"featureId":"VAR_013523","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912450","featureCrossReferences":[{"database":"dbSNP","id":"rs121912450"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8069312"}],"featureId":"VAR_007135","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1169198442","featureCrossReferences":[{"database":"dbSNP","id":"rs1169198442"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_045877","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"in ALS1; mild form; ubiquitinated by RNF19A. Ubiquitinated by MARCHF5; leading to the degradation of mitochondrial SOD1; dbSNP:rs121912431","featureCrossReferences":[{"database":"dbSNP","id":"rs121912431"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12210393"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9541385"}],"featureId":"VAR_007136","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1555836520","featureCrossReferences":[{"database":"dbSNP","id":"rs1555836520"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9706719"}],"featureId":"VAR_013524","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912432","featureCrossReferences":[{"database":"dbSNP","id":"rs121912432"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"}],"featureId":"VAR_007137","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912434","featureCrossReferences":[{"database":"dbSNP","id":"rs121912434"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"}],"featureId":"VAR_007139","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912433","featureCrossReferences":[{"database":"dbSNP","id":"rs121912433"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"}],"featureId":"VAR_007138","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"in ALS1; reduces structural stability and enzyme activity; increases tendency to form fibrillar aggregates; dbSNP:rs121912435","featureCrossReferences":[{"database":"dbSNP","id":"rs121912435"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"}],"featureId":"VAR_007140","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"in ALS1; slow progression; dbSNP:rs121912457","featureCrossReferences":[{"database":"dbSNP","id":"rs121912457"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11369193"}],"featureId":"VAR_013525","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"in ALS1; 80% of wild-type activity; ubiquitinated by RNF19A; dbSNP:rs121912443","featureCrossReferences":[{"database":"dbSNP","id":"rs121912443"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754496"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7836951"}],"featureId":"VAR_007141","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568809175","featureCrossReferences":[{"database":"dbSNP","id":"rs1568809175"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8528216"}],"featureId":"VAR_007142","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568809172","featureCrossReferences":[{"database":"dbSNP","id":"rs1568809172"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_045878","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568809178","featureCrossReferences":[{"database":"dbSNP","id":"rs1568809178"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9706719"}],"featureId":"VAR_013526","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"in ALS1; reduces tendency to form fibrillar aggregates; dbSNP:rs986277034","featureCrossReferences":[{"database":"dbSNP","id":"rs986277034"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18301754"}],"featureId":"VAR_045879","alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568810275","featureCrossReferences":[{"database":"dbSNP","id":"rs1568810275"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12210393"}],"featureId":"VAR_013527","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568810289","featureCrossReferences":[{"database":"dbSNP","id":"rs1568810289"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21247266"}],"featureId":"VAR_065560","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568810289","featureCrossReferences":[{"database":"dbSNP","id":"rs1568810289"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9706719"}],"featureId":"VAR_013528","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912455","featureCrossReferences":[{"database":"dbSNP","id":"rs121912455"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9455977"}],"featureId":"VAR_008718","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1601157750","featureCrossReferences":[{"database":"dbSNP","id":"rs1601157750"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9365366"}],"featureId":"VAR_013529","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"in ALS1; sporadic form; interferes with zinc binding; dbSNP:rs121912458","featureCrossReferences":[{"database":"dbSNP","id":"rs121912458"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12402272"}],"featureId":"VAR_016874","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1315541036","featureCrossReferences":[{"database":"dbSNP","id":"rs1315541036"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9706719"}],"featureId":"VAR_013530","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912452","featureCrossReferences":[{"database":"dbSNP","id":"rs121912452"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7655471"}],"featureId":"VAR_007143","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"in ALS1; ubiquitinated by RNF19A; interferes with zinc-binding; ubiquitinated by MARCHF5; leading to the degradation of mitochondrial SOD1; dbSNP:rs121912436","featureCrossReferences":[{"database":"dbSNP","id":"rs121912436"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18378676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19741096"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.52"}],"featureId":"VAR_007144","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs11556620","featureCrossReferences":[{"database":"dbSNP","id":"rs11556620"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27604643"}],"featureId":"VAR_013531","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1339283341","featureCrossReferences":[{"database":"dbSNP","id":"rs1339283341"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27604643"}],"featureId":"VAR_045880","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568810660","featureCrossReferences":[{"database":"dbSNP","id":"rs1568810660"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_045881","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1280042397","featureCrossReferences":[{"database":"dbSNP","id":"rs1280042397"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31086828"}],"featureId":"VAR_013532","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"in ALS1; does not seem to be linked with a decrease in activity; dbSNP:rs80265967","featureCrossReferences":[{"database":"dbSNP","id":"rs80265967"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18301754"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20460594"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7647793"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7655469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9365366"}],"featureId":"VAR_007145","alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs80265967","featureCrossReferences":[{"database":"dbSNP","id":"rs80265967"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.86"}],"featureId":"VAR_013533","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in ALS1; increases tendency to form fibrillar aggregates; ubiquitinated by RNF19A; ubiquitinated by MARCHF5; dbSNP:rs121912438","featureCrossReferences":[{"database":"dbSNP","id":"rs121912438"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18301754"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19741096"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"}],"featureId":"VAR_007146","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912437","featureCrossReferences":[{"database":"dbSNP","id":"rs121912437"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"}],"featureId":"VAR_007147","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912438","featureCrossReferences":[{"database":"dbSNP","id":"rs121912438"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18301754"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7951252"}],"featureId":"VAR_007148","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in ALS1; 30% of wild-type activity; dbSNP:rs121912437","featureCrossReferences":[{"database":"dbSNP","id":"rs121912437"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7700376"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8528216"}],"featureId":"VAR_007149","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912438","featureCrossReferences":[{"database":"dbSNP","id":"rs121912438"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8938700"}],"featureId":"VAR_008719","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568810690","featureCrossReferences":[{"database":"dbSNP","id":"rs1568810690"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21220647"}],"featureId":"VAR_065194","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"in ALS1; increases tendency to form fibrillar aggregates; dbSNP:rs1555836806","featureCrossReferences":[{"database":"dbSNP","id":"rs1555836806"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18301754"}],"featureId":"VAR_045882","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912439","featureCrossReferences":[{"database":"dbSNP","id":"rs121912439"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"}],"featureId":"VAR_007150","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs76731700","featureCrossReferences":[{"database":"dbSNP","id":"rs76731700"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20460594"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8875253"}],"featureId":"VAR_013534","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568810721","featureCrossReferences":[{"database":"dbSNP","id":"rs1568810721"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27604643"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7655468"}],"featureId":"VAR_007151","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568810715","featureCrossReferences":[{"database":"dbSNP","id":"rs1568810715"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27604643"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7870076"}],"featureId":"VAR_007152","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912445","featureCrossReferences":[{"database":"dbSNP","id":"rs121912445"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7501156"}],"featureId":"VAR_008720","alternativeSequence":{"originalSequence":"I","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1378590183","featureCrossReferences":[{"database":"dbSNP","id":"rs1378590183"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_013535","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912440","featureCrossReferences":[{"database":"dbSNP","id":"rs121912440"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"}],"featureId":"VAR_007153","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1359299834","featureCrossReferences":[{"database":"dbSNP","id":"rs1359299834"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24283821"}],"featureId":"VAR_013536","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1601158483","featureCrossReferences":[{"database":"dbSNP","id":"rs1601158483"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27604643"}],"featureId":"VAR_077327","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1299542356","featureCrossReferences":[{"database":"dbSNP","id":"rs1299542356"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12210393"}],"featureId":"VAR_013537","alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs74315452","featureCrossReferences":[{"database":"dbSNP","id":"rs74315452"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7951252"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8528216"}],"featureId":"VAR_007154","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"in ALS1; destabilizes dimeric protein structure and increases tendency to form fibrillar aggregates; dbSNP:rs121912441","featureCrossReferences":[{"database":"dbSNP","id":"rs121912441"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10732812"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15056757"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7997024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8446170"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8528216"}],"featureId":"VAR_007155","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568810789","featureCrossReferences":[{"database":"dbSNP","id":"rs1568810789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_013538","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1301635320","featureCrossReferences":[{"database":"dbSNP","id":"rs1301635320"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7881433"}],"featureId":"VAR_007156","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1235629842","featureCrossReferences":[{"database":"dbSNP","id":"rs1235629842"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_045883","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"in ALS1","featureId":"VAR_008721","alternativeSequence":{"originalSequence":"V","alternativeSequences":["VFLQ"]}},{"type":"Natural variant","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568811366","featureCrossReferences":[{"database":"dbSNP","id":"rs1568811366"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_045884","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568811366","featureCrossReferences":[{"database":"dbSNP","id":"rs1568811366"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8938700"}],"featureId":"VAR_008722","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568811372","featureCrossReferences":[{"database":"dbSNP","id":"rs1568811372"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8528216"}],"featureId":"VAR_007157","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912454","featureCrossReferences":[{"database":"dbSNP","id":"rs121912454"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11535232"}],"featureId":"VAR_013539","alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"in ALS; dbSNP:rs1568811423","featureCrossReferences":[{"database":"dbSNP","id":"rs1568811423"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8938700"}],"featureId":"VAR_008723","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in ALS1; reduced metal binding; increases tendency to form fibrillar aggregates; dbSNP:rs121912451","featureCrossReferences":[{"database":"dbSNP","id":"rs121912451"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754496"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8990014"}],"featureId":"VAR_007158","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1804449","featureCrossReferences":[{"database":"dbSNP","id":"rs1804449"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887412"}],"featureId":"VAR_007159","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1482760341","featureCrossReferences":[{"database":"dbSNP","id":"rs1482760341"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18301754"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"}],"featureId":"VAR_007160","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912446","featureCrossReferences":[{"database":"dbSNP","id":"rs121912446"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7496169"}],"featureId":"VAR_008724","alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912447","featureCrossReferences":[{"database":"dbSNP","id":"rs121912447"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7496169"}],"featureId":"VAR_008725","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568811515","featureCrossReferences":[{"database":"dbSNP","id":"rs1568811515"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8875253"}],"featureId":"VAR_013540","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1568811520","featureCrossReferences":[{"database":"dbSNP","id":"rs1568811520"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506936"}],"featureId":"VAR_045885","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1476760624","featureCrossReferences":[{"database":"dbSNP","id":"rs1476760624"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8351519"}],"featureId":"VAR_007161","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs567511139","featureCrossReferences":[{"database":"dbSNP","id":"rs567511139"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7795609"}],"featureId":"VAR_007162","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs1424014997","featureCrossReferences":[{"database":"dbSNP","id":"rs1424014997"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7887412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8528216"}],"featureId":"VAR_007163","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"in ALS1; dbSNP:rs121912449","featureCrossReferences":[{"database":"dbSNP","id":"rs121912449"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8682505"}],"featureId":"VAR_007164","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"No palmitoylation, reduced nuclear targeting. Enhances formation of fibrillar aggregates in the absence of bound zinc; when associated with S-58; S-112 and S-147.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17070542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22496122"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Abolishes dimerization; when associated with Q-134.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10329151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"}],"alternativeSequence":{"originalSequence":"FG","alternativeSequences":["EE"]}},{"type":"Mutagenesis","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Exhibits very slow copper acquisition.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17070542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23625804"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Enhances formation of fibrillar aggregates in the absence of bound zinc; when associated with S-7; S-112 and S-147.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17070542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23625804"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Loss of zinc binding and enhanced tendency to form aggregates; when associated with A-84.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17888947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Destabilization of dimer and loss of zinc binding; when associated with S-84.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17888947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Loss of zinc binding and enhanced tendency to form aggregates; when associated with A-81.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17888947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Destabilization of dimer and loss of zinc binding; when associated with S-81.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17888947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Enhances formation of fibrillar aggregates in the absence of bound zinc; when associated with S-7; S-58 and S-147.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17070542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Decreased succinylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24140062"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Mimicks constitutive succinylation state; decreased activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24140062"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Abolishes dimerization; when associated with E-50 and E-51.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10329151"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"Exhibits very slow copper acquisition.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17070542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23625804"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"Enhances formation of fibrillar aggregates in the absence of bound zinc; when associated with S-7; S-58 and S-112.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17070542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18552350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23625804"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"in Ref. 3; no nucleotide entry","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"in Ref. 3; no nucleotide entry","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["V"]}},{"type":"Beta strand","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RK7"}]},{"type":"Beta strand","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NAM"}]},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7FB6"}]},{"type":"Helix","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KMG"}]},{"type":"Beta strand","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KMG"}]},{"type":"Beta strand","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RK7"}]},{"type":"Beta strand","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1MFM"}]},{"type":"Turn","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2MP3"}]},{"type":"Beta strand","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Helix","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1SPD"}]},{"type":"Beta strand","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Helix","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VZF"}]},{"type":"Beta strand","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8IHV"}]},{"type":"Beta strand","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LU5"}]},{"type":"Beta strand","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Helix","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Turn","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A7U"}]},{"type":"Beta strand","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5O3Y"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0036","category":"Disease","name":"Amyotrophic lateral sclerosis"},{"id":"KW-0049","category":"Molecular function","name":"Antioxidant"},{"id":"KW-0186","category":"Ligand","name":"Copper"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0523","category":"Disease","name":"Neurodegeneration"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"6577438","citationType":"journal article","authors":["Sherman L.","Dafni N.","Lieman-Hurwitz J.","Groner Y."],"citationCrossReferences":[{"database":"PubMed","id":"6577438"},{"database":"DOI","id":"10.1073/pnas.80.18.5465"}],"title":"Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA.","publicationDate":"1983","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"5465","lastPage":"5469","volume":"80"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"3160582","citationType":"journal article","authors":["Levanon D.","Lieman-Hurwitz J.","Dafni N.","Wigderson M.","Sherman L.","Bernstein Y.","Laver-Rudich Z.","Danciger E.","Stein O.","Groner Y."],"citationCrossReferences":[{"database":"PubMed","id":"3160582"},{"database":"DOI","id":"10.1002/j.1460-2075.1985.tb02320.x"}],"title":"Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase.","publicationDate":"1985","journal":"EMBO J.","firstPage":"77","lastPage":"84","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"3889846","citationType":"journal article","authors":["Hallewell R.A.","Masiarz F.R.","Najarian R.C.","Puma J.P.","Quiroga M.R.","Randolph A.","Sanchez-Pescador R.","Scandella C.J.","Smith B.","Steimer K.S.","Mullenbach G.T."],"citationCrossReferences":[{"database":"PubMed","id":"3889846"},{"database":"DOI","id":"10.1093/nar/13.6.2017"}],"title":"Human Cu/Zn superoxide dismutase cDNA: isolation of clones synthesising high levels of active or inactive enzyme from an expression library.","publicationDate":"1985","journal":"Nucleic Acids Res.","firstPage":"2017","lastPage":"2034","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":4,"citation":{"id":"2853161","citationType":"journal article","authors":["Kajihara J.","Enomoto M.","Nishijima K.","Yabuuchi M.","Katoh K."],"citationCrossReferences":[{"database":"PubMed","id":"2853161"},{"database":"DOI","id":"10.1093/oxfordjournals.jbchem.a122562"}],"title":"Comparison of properties between human recombinant and placental copper-zinc SOD.","publicationDate":"1988","journal":"J. Biochem.","firstPage":"851","lastPage":"854","volume":"104"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":5,"citation":{"id":"CI-4DBCSGCOR841P","citationType":"submission","authors":["Xu Y.","Hu X.","Zhou Y.","Peng X.","Yuan J.","Qiang B."],"publicationDate":"JUL-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":6,"citation":{"id":"CI-DT8Q1C3BTEBRL","citationType":"submission","authors":["Lu X.","Hui L."],"publicationDate":"OCT-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":7,"citation":{"id":"CI-E4S0L36PQ5ENR","citationType":"submission","authors":["Staege M.S.","Bergmann S.","Heins S."],"title":"Direct sequencing and cloning of superoxide dismutase 1 from peripheral blood.","publicationDate":"NOV-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":8,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Colon","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"CI-65UA89QGSSD50","citationType":"submission","authors":["Halleck A.","Ebert L.","Mkoundinya M.","Schick M.","Eisenstein S.","Neubert P.","Kstrang K.","Schatten R.","Shen B.","Henze S.","Mar W.","Korn B.","Zuo D.","Hu Y.","LaBaer J."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":10,"citation":{"id":"CI-54UT03IDST7RQ","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":11,"citation":{"id":"CI-86ALM2TFFQ300","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"NOV-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":12,"citation":{"id":"10830953","citationType":"journal article","authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.-S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.-K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Shibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brandt P.","Scharfe M.","Schoen O.","Desario A.","Reichelt J.","Kauer G.","Bloecker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.-L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":13,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":14,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"6770891","citationType":"journal article","authors":["Jabusch J.R.","Farb D.L.","Kerschensteiner D.A.","Deutsch H.F."],"citationCrossReferences":[{"database":"PubMed","id":"6770891"},{"database":"DOI","id":"10.1021/bi00552a005"}],"title":"Some sulfhydryl properties and primary structure of human erythrocyte superoxide dismutase.","publicationDate":"1980","journal":"Biochemistry","firstPage":"2310","lastPage":"2316","volume":"19"},"referencePositions":["PROTEIN SEQUENCE OF 2-154"]},{"referenceNumber":16,"citation":{"id":"7002610","citationType":"journal article","authors":["Barra D.","Martini F.","Bannister J.V.","Schinina M.E.","Rotilio G.","Bannister W.H.","Bossa F."],"citationCrossReferences":[{"database":"PubMed","id":"7002610"},{"database":"DOI","id":"10.1016/0014-5793(80)81044-1"}],"title":"The complete amino acid sequence of human Cu/Zn superoxide dismutase.","publicationDate":"1980","journal":"FEBS Lett.","firstPage":"53","lastPage":"56","volume":"120"},"referencePositions":["PROTEIN SEQUENCE OF 2-154","CLEAVAGE OF INITIATOR METHIONINE","ACETYLATION AT ALA-2"]},{"referenceNumber":17,"citation":{"id":"CI-652NQH91LIDA8","citationType":"submission","authors":["Lubec G.","Chen W.-Q.","Sun Y."],"publicationDate":"DEC-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 11-24 AND 81-116"],"referenceComments":[{"value":"Fetal brain cortex","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"8528216","citationType":"journal article","authors":["Enayat Z.E.","Orrell R.W.","Claus A.","Ludolph A.","Bachus R.","Brockmueller J.","Ray-Chaudhuri K.","Radunovic A.","Shaw C.","Wilkinson J.","King A.","Swash M.","Leigh P.N.","de Belleroche J.","Powell J."],"citationCrossReferences":[{"database":"PubMed","id":"8528216"},{"database":"DOI","id":"10.1093/hmg/4.7.1239"}],"title":"Two novel mutations in the gene for copper zinc superoxide dismutase in UK families with amyotrophic lateral sclerosis.","publicationDate":"1995","journal":"Hum. Mol. Genet.","firstPage":"1239","lastPage":"1240","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-56 AND 120-154","VARIANTS ALS1 GLN-49; ARG-94; THR-113; THR-114; HIS-126 AND THR-150"]},{"referenceNumber":19,"citation":{"id":"8682505","citationType":"journal article","authors":["Kostrzewa M.","Daamian M.","Mueller U."],"citationCrossReferences":[{"database":"PubMed","id":"8682505"},{"database":"DOI","id":"10.1007/s004390050157"}],"title":"Superoxide dismutase 1: identification of a novel mutation in a case of familial amyotrophic lateral sclerosis.","publicationDate":"1996","journal":"Hum. Genet.","firstPage":"48","lastPage":"50","volume":"98"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-154","VARIANT ALS1 THR-152"]},{"referenceNumber":20,"citation":{"id":"15326189","citationType":"journal article","authors":["Arnesano F.","Banci L.","Bertini I.","Martinelli M.","Furukawa Y.","O'Halloran T.V."],"citationCrossReferences":[{"database":"PubMed","id":"15326189"},{"database":"DOI","id":"10.1074/jbc.m406021200"}],"title":"The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"47998","lastPage":"48003","volume":"279"},"referencePositions":["SUBUNIT","DISULFIDE BOND"]},{"referenceNumber":21,"citation":{"id":"18948262","citationType":"journal article","authors":["Kirby K.","Jensen L.T.","Binnington J.","Hilliker A.J.","Ulloa J.","Culotta V.C.","Phillips J.P."],"citationCrossReferences":[{"database":"PubMed","id":"18948262"},{"database":"DOI","id":"10.1074/jbc.m807131200"}],"title":"Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"35393","lastPage":"35401","volume":"283"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","ACTIVITY REGULATION"]},{"referenceNumber":22,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-123","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":24,"citation":{"id":"20600836","citationType":"journal article","authors":["Medinas D.B.","Gozzo F.C.","Santos L.F.","Iglesias A.H.","Augusto O."],"citationCrossReferences":[{"database":"PubMed","id":"20600836"},{"database":"DOI","id":"10.1016/j.freeradbiomed.2010.06.018"}],"title":"A ditryptophan cross-link is responsible for the covalent dimerization of human superoxide dismutase 1 during its bicarbonate-dependent peroxidase activity.","publicationDate":"2010","journal":"Free Radic. Biol. Med.","firstPage":"1046","lastPage":"1053","volume":"49"},"referencePositions":["SUBUNIT","DITRYPTOPHAN CROSS-LINK AT TRP-33"]},{"referenceNumber":25,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":27,"citation":{"id":"22496122","citationType":"journal article","authors":["Marin E.P.","Derakhshan B.","Lam T.T.","Davalos A.","Sessa W.C."],"citationCrossReferences":[{"database":"PubMed","id":"22496122"},{"database":"DOI","id":"10.1161/circresaha.112.269514"}],"title":"Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.","publicationDate":"2012","journal":"Circ. Res.","firstPage":"1336","lastPage":"1344","volume":"110"},"referencePositions":["PALMITOYLATION AT CYS-7","SUBCELLULAR LOCATION","MUTAGENESIS OF CYS-7"]},{"referenceNumber":28,"citation":{"id":"22905912","citationType":"journal article","authors":["Rosenow A.","Noben J.P.","Jocken J.","Kallendrusch S.","Fischer-Posovszky P.","Mariman E.C.","Renes J."],"citationCrossReferences":[{"database":"PubMed","id":"22905912"},{"database":"DOI","id":"10.1021/pr300539b"}],"title":"Resveratrol-induced changes of the human adipocyte secretion profile.","publicationDate":"2012","journal":"J. Proteome Res.","firstPage":"4733","lastPage":"4743","volume":"11"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"24140062","citationType":"journal article","authors":["Lin Z.F.","Xu H.B.","Wang J.Y.","Lin Q.","Ruan Z.","Liu F.B.","Jin W.","Huang H.H.","Chen X."],"citationCrossReferences":[{"database":"PubMed","id":"24140062"},{"database":"DOI","id":"10.1016/j.bbrc.2013.10.033"}],"title":"SIRT5 desuccinylates and activates SOD1 to eliminate ROS.","publicationDate":"2013","journal":"Biochem. Biophys. Res. Commun.","firstPage":"191","lastPage":"195","volume":"441"},"referencePositions":["SUCCINYLATION AT LYS-123","DESUCCINYLATION BY SIRT5","MUTAGENESIS OF LYS-123","CATALYTIC ACTIVITY","FUNCTION"]},{"referenceNumber":30,"citation":{"id":"23625804","citationType":"journal article","authors":["Banci L.","Cantini F.","Kozyreva T.","Rubino J.T."],"citationCrossReferences":[{"database":"PubMed","id":"23625804"},{"database":"DOI","id":"10.1002/cbic.201300042"}],"title":"Mechanistic aspects of hSOD1 maturation from the solution structure of Cu(I) -loaded hCCS domain 1 and analysis of disulfide-free hSOD1 mutants.","publicationDate":"2013","journal":"ChemBioChem","firstPage":"1839","lastPage":"1844","volume":"14"},"referencePositions":["MUTAGENESIS OF CYS-58 AND CYS-147"]},{"referenceNumber":31,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND SER-103","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":32,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":33,"citation":{"id":"30037290","citationType":"journal article","authors":["Wang M.","Saw H.P.","Cui F.F.","Lin S.Y.","Chang H.T.","Chiu C.D."],"citationCrossReferences":[{"database":"PubMed","id":"30037290"},{"database":"DOI","id":"10.1080/10715762.2018.1504293"}],"title":"pLG72 induces superoxide radicals via interaction and aggregation with SOD1.","publicationDate":"2018","journal":"Free Radic. Res.","firstPage":"970","lastPage":"976","volume":"52"},"referencePositions":["INTERACTION WITH DAOA"]},{"referenceNumber":34,"citation":{"id":"31292775","citationType":"journal article","authors":["Skopp A.","Boyd S.D.","Ullrich M.S.","Liu L.","Winkler D.D."],"citationCrossReferences":[{"database":"PubMed","id":"31292775"},{"database":"DOI","id":"10.1007/s10534-019-00206-3"}],"title":"Copper-zinc superoxide dismutase (Sod1) activation terminates interaction between its copper chaperone (Ccs) and the cytosolic metal-binding domain of the copper importer Ctr1.","publicationDate":"2019","journal":"BioMetals","firstPage":"695","lastPage":"705","volume":"32"},"referencePositions":["INTERACTION WITH CCS","SUBUNIT"]},{"referenceNumber":35,"citation":{"id":"31332433","citationType":"journal article","authors":["Park J.H.","Elpers C.","Reunert J.","McCormick M.L.","Mohr J.","Biskup S.","Schwartz O.","Rust S.","Grueneberg M.","Seelhoefer A.","Schara U.","Boltshauser E.","Spitz D.R.","Marquardt T."],"citationCrossReferences":[{"database":"PubMed","id":"31332433"},{"database":"DOI","id":"10.1093/brain/awz182"}],"title":"SOD1 deficiency: a novel syndrome distinct from amyotrophic lateral sclerosis.","publicationDate":"2019","journal":"Brain","firstPage":"2230","lastPage":"2237","volume":"142"},"referencePositions":["INVOLVEMENT IN STAHP"]},{"referenceNumber":36,"citation":{"id":"31314961","citationType":"journal article","authors":["Andersen P.M.","Nordstroem U.","Tsiakas K.","Johannsen J.","Volk A.E.","Bierhals T.","Zetterstroem P.","Marklund S.L.","Hempel M.","Santer R."],"citationCrossReferences":[{"database":"PubMed","id":"31314961"},{"database":"DOI","id":"10.1056/nejmc1905039"}],"title":"Phenotype in an Infant with SOD1 Homozygous Truncating Mutation.","publicationDate":"2019","journal":"N. Engl. J. Med.","firstPage":"486","lastPage":"488","volume":"381"},"referencePositions":["INVOLVEMENT IN STAHP"]},{"referenceNumber":37,"citation":{"id":"36630448","citationType":"journal article","authors":["Switzer C.H.","Kasamatsu S.","Ihara H.","Eaton P."],"citationCrossReferences":[{"database":"PubMed","id":"36630448"},{"database":"DOI","id":"10.1073/pnas.2205044120"}],"title":"SOD1 is an essential H2S detoxifying enzyme.","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2205044120","lastPage":"e2205044120","volume":"120"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","COFACTOR"]},{"referenceNumber":38,"citation":{"id":"1463506","citationType":"journal article","authors":["Parge H.E.","Hallewell R.A.","Tainer J.A."],"citationCrossReferences":[{"database":"PubMed","id":"1463506"},{"database":"DOI","id":"10.1073/pnas.89.13.6109"}],"title":"Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6109","lastPage":"6113","volume":"89"},"referencePositions":["X-RAY CRYSTALLOGRAPHY"]},{"referenceNumber":39,"citation":{"id":"9541385","citationType":"journal article","authors":["Hart P.J.","Liu H.","Pellegrini M.","Nersissian A.M.","Gralla E.B.","Valentine J.S.","Eisenberg D."],"citationCrossReferences":[{"database":"PubMed","id":"9541385"},{"database":"DOI","id":"10.1002/pro.5560070302"}],"title":"Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis.","publicationDate":"1998","journal":"Protein Sci.","firstPage":"545","lastPage":"555","volume":"7"},"referencePositions":["X-RAY CRYSTALLOGRAPHY OF VARIANT ALS1 ARG-38"]},{"referenceNumber":40,"citation":{"id":"9718300","citationType":"journal article","authors":["Banci L.","Benedetto M.","Bertini I.","del Conte R.","Piccioli M.","Viezzoli M.S."],"citationCrossReferences":[{"database":"PubMed","id":"9718300"},{"database":"DOI","id":"10.1021/bi9803473"}],"title":"Solution structure of reduced monomeric Q133M2 copper, zinc superoxide dismutase (SOD). Why is SOD a dimeric enzyme?","publicationDate":"1998","journal":"Biochemistry","firstPage":"11780","lastPage":"11791","volume":"37"},"referencePositions":["STRUCTURE BY NMR"]},{"referenceNumber":41,"citation":{"id":"10329151","citationType":"journal article","authors":["Ferraroni M.","Rypniewski W.","Wilson K.S.","Viezzoli M.S.","Banci L.","Bertini I.","Mangani S."],"citationCrossReferences":[{"database":"PubMed","id":"10329151"},{"database":"DOI","id":"10.1006/jmbi.1999.2681"}],"title":"The crystal structure of the monomeric human SOD mutant F50E/G51E/E133Q at atomic resolution. The enzyme mechanism revisited.","publicationDate":"1999","journal":"J. Mol. Biol.","firstPage":"413","lastPage":"426","volume":"288"},"referencePositions":["X-RAY CRYSTALLOGRAPHY OF MUTANT GLU-51/GLU-52/GLN-134","SUBUNIT","MUTAGENESIS OF 51-PHE-GLY-52 AND GLU-134"]},{"referenceNumber":42,"citation":{"id":"12911296","citationType":"journal article","authors":["Banci L.","Bertini I.","Cramaro F.","Del Conte R.","Viezzoli M.S."],"citationCrossReferences":[{"database":"PubMed","id":"12911296"},{"database":"DOI","id":"10.1021/bi034324m"}],"title":"Solution structure of Apo Cu,Zn superoxide dismutase: role of metal ions in protein folding.","publicationDate":"2003","journal":"Biochemistry","firstPage":"9543","lastPage":"9553","volume":"42"},"referencePositions":["STRUCTURE BY NMR OF MUTANT GLU51/GLU-52/GLN-134","SUBUNIT"]},{"referenceNumber":43,"citation":{"id":"12963370","citationType":"journal article","authors":["DiDonato M.","Craig L.","Huff M.E.","Thayer M.M.","Cardoso R.M.","Kassmann C.J.","Lo T.P.","Bruns C.K.","Powers E.T.","Kelly J.W.","Getzoff E.D.","Tainer J.A."],"citationCrossReferences":[{"database":"PubMed","id":"12963370"},{"database":"DOI","id":"10.1016/s0022-2836(03)00889-1"}],"title":"ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization.","publicationDate":"2003","journal":"J. Mol. Biol.","firstPage":"601","lastPage":"615","volume":"332"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH COPPER AND ZINC IONS","DISULFIDE BOND","SUBUNIT","CHARACTERIZATION OF VARIANTS ALS1 VAL-5 AND ARG-44"]},{"referenceNumber":44,"citation":{"id":"12754496","citationType":"journal article","authors":["Elam J.S.","Taylor A.B.","Strange R.","Antonyuk S.","Doucette P.A.","Rodriguez J.A.","Hasnain S.S.","Hayward L.J.","Valentine J.S.","Yeates T.O.","Hart P.J."],"citationCrossReferences":[{"database":"PubMed","id":"12754496"},{"database":"DOI","id":"10.1038/nsb935"}],"title":"Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS.","publicationDate":"2003","journal":"Nat. Struct. Biol.","firstPage":"461","lastPage":"467","volume":"10"},"referencePositions":["X-RAY CRYSTALLOGRAPHY OF VARIANTS ALS1 ASN-135 AND ARG-47","FORMATION OF FIBRILLAR AGGREGATES"]},{"referenceNumber":45,"citation":{"id":"15056757","citationType":"journal article","authors":["Hough M.A.","Grossmann J.G.","Antonyuk S.V.","Strange R.W.","Doucette P.A.","Rodriguez J.A.","Whitson L.J.","Hart P.J.","Hayward L.J.","Valentine J.S.","Hasnain S.S."],"citationCrossReferences":[{"database":"PubMed","id":"15056757"},{"database":"DOI","id":"10.1073/pnas.0305143101"}],"title":"Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"5976","lastPage":"5981","volume":"101"},"referencePositions":["X-RAY CRYSTALLOGRAPHY OF VARIANTS ALS1 VAL-5 AND THR-114","CHARACTERIZATION OF VARIANTS ALS1 VAL-5 AND THR-114"]},{"referenceNumber":46,"citation":{"id":"16291742","citationType":"journal article","authors":["Banci L.","Bertini I.","Cantini F.","D'Amelio N.","Gaggelli E."],"citationCrossReferences":[{"database":"PubMed","id":"16291742"},{"database":"DOI","id":"10.1074/jbc.m506497200"}],"title":"Human SOD1 before harboring the catalytic metal: solution structure of copper-depleted, disulfide-reduced form.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"2333","lastPage":"2337","volume":"281"},"referencePositions":["STRUCTURE BY NMR OF MUTANT ALA-7/SER-112","SUBUNIT"]},{"referenceNumber":47,"citation":{"id":"16406071","citationType":"journal article","authors":["Strange R.W.","Antonyuk S.V.","Hough M.A.","Doucette P.A.","Valentine J.S.","Hasnain S.S."],"citationCrossReferences":[{"database":"PubMed","id":"16406071"},{"database":"DOI","id":"10.1016/j.jmb.2005.11.081"}],"title":"Variable metallation of human superoxide dismutase: atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes.","publicationDate":"2006","journal":"J. Mol. Biol.","firstPage":"1152","lastPage":"1162","volume":"356"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEXES WITH COPPER AND ZINC IONS","DISULFIDE BOND","SUBUNIT"]},{"referenceNumber":48,"citation":{"id":"17070542","citationType":"journal article","authors":["Hoernberg A.","Logan D.T.","Marklund S.L.","Oliveberg M."],"citationCrossReferences":[{"database":"PubMed","id":"17070542"},{"database":"DOI","id":"10.1016/j.jmb.2006.09.048"}],"title":"The coupling between disulphide status, metallation and dimer interface strength in Cu/Zn superoxide dismutase.","publicationDate":"2007","journal":"J. Mol. Biol.","firstPage":"333","lastPage":"342","volume":"365"},"referencePositions":["X-RAY CRYSTALLOGRAPHY OF MUTANTS ALA-7/ALA-112 AND ALA-7/ALA-58/ALA-112/ALA-147","MUTAGENESIS OF CYS-7; CYS-58; CYS-112 AND CYS-147"]},{"referenceNumber":49,"citation":{"id":"17888947","citationType":"journal article","authors":["Roberts B.R.","Tainer J.A.","Getzoff E.D.","Malencik D.A.","Anderson S.R.","Bomben V.C.","Meyers K.R.","Karplus P.A.","Beckman J.S."],"citationCrossReferences":[{"database":"PubMed","id":"17888947"},{"database":"DOI","id":"10.1016/j.jmb.2007.07.043"}],"title":"Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS.","publicationDate":"2007","journal":"J. Mol. Biol.","firstPage":"877","lastPage":"890","volume":"373"},"referencePositions":["X-RAY CRYSTALLOGRAPHY OF MUTANT SER-81/SER-84 IN COMPLEX WITH COPPER IONS","SUBUNIT","MUTAGENESIS OF HIS-81 AND ASP-84","COFACTOR"]},{"referenceNumber":50,"citation":{"id":"17548825","citationType":"journal article","authors":["Strange R.W.","Yong C.W.","Smith W.","Hasnain S.S."],"citationCrossReferences":[{"database":"PubMed","id":"17548825"},{"database":"DOI","id":"10.1073/pnas.0703857104"}],"title":"Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu-Zn superoxide dismutase.","publicationDate":"2007","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10040","lastPage":"10044","volume":"104"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH COPPER AND ZINC IONS","SUBUNIT","FORMATION OF FIBRILLAR AGGREGATES BY ZINC-DEPLETED SOD1"]},{"referenceNumber":51,"citation":{"id":"18378676","citationType":"journal article","authors":["Cao X.","Antonyuk S.V.","Seetharaman S.V.","Whitson L.J.","Taylor A.B.","Holloway S.P.","Strange R.W.","Doucette P.A.","Valentine J.S.","Tiwari A.","Hayward L.J.","Padua S.","Cohlberg J.A.","Hasnain S.S.","Hart P.J."],"citationCrossReferences":[{"database":"PubMed","id":"18378676"},{"database":"DOI","id":"10.1074/jbc.m801522200"}],"title":"Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"16169","lastPage":"16177","volume":"283"},"referencePositions":["X-RAY CRYSTALLOGRAPHY OF VARIANT ALS1 ARG-86","CHARACTERIZATION OF VARIANT ALS1 ARG-86"]},{"referenceNumber":52,"citation":{"id":"CI-BB2LVBROS7G2O","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Crystal structure of human Cu-Zn superoxide dismutase mutant G85R (P21).","publicationDate":"APR-2008","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY OF VARIANT ALS1 ARG-86"]},{"referenceNumber":53,"citation":{"id":"8592323","citationType":"journal article","authors":["de Belleroche J.","Orrell R.","King A."],"citationCrossReferences":[{"database":"PubMed","id":"8592323"},{"database":"DOI","id":"10.1136/jmg.32.11.841"}],"title":"Familial amyotrophic lateral sclerosis/motor neurone disease (FALS): a review of current developments.","publicationDate":"1995","journal":"J. Med. Genet.","firstPage":"841","lastPage":"847","volume":"32"},"referencePositions":["REVIEW ON VARIANTS"]},{"referenceNumber":54,"citation":{"id":"20727846","citationType":"journal article","authors":["Seetharaman S.V.","Taylor A.B.","Holloway S.","Hart P.J."],"citationCrossReferences":[{"database":"PubMed","id":"20727846"},{"database":"DOI","id":"10.1016/j.abb.2010.08.014"}],"title":"Structures of mouse SOD1 and human/mouse SOD1 chimeras.","publicationDate":"2010","journal":"Arch. Biochem. Biophys.","firstPage":"183","lastPage":"190","volume":"503"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH ZINC"]},{"referenceNumber":55,"citation":{"id":"8446170","citationType":"journal article","authors":["Rosen D.R.","Siddique T.","Patterson D.","Figlewicz D.A.","Sapp P.","Hentati A.","Donaldson D.","Goto J.","O'Regan J.P.","Deng H.-X.","Rahmani Z.","Krizus A.","McKenna-Yasek D.","Cayabyab A.","Gaston S.M.","Berger R.","Tanzi R.E.","Halperin J.J.","Herzfeldt B.","van den Bergh R.","Hung W.-Y.","Bird T.","Deng G.","Mulder D.W.","Smyth C.","Laing N.G.","Soriano E.","Pericak-Vance M.A.","Haines J.","Rouleau G.A.","Gusella J.S.","Horvitz H.R.","Brown R.H. Jr."],"citationCrossReferences":[{"database":"PubMed","id":"8446170"},{"database":"DOI","id":"10.1038/362059a0"}],"title":"Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.","publicationDate":"1993","journal":"Nature","firstPage":"59","lastPage":"62","volume":"362"},"referencePositions":["VARIANTS ALS1 ARG-38; VAL-39; ASP-42; SER-42; ARG-44; ARG-86; ALA-94; CYS-94; GLY-101; VAL-107 AND THR-114"]},{"referenceNumber":56,"citation":{"id":"8332197","citationType":"journal article","authors":["Rosen D.R."],"citationCrossReferences":[{"database":"PubMed","id":"8332197"},{"database":"DOI","id":"10.1038/364362c0"}],"publicationDate":"1993","journal":"Nature","firstPage":"362","lastPage":"362","volume":"364"},"referencePositions":["ERRATUM OF PUBMED:8446170"]},{"referenceNumber":57,"citation":{"id":"8351519","citationType":"journal article","authors":["Deng H.-X.","Hentati A.","Tainer J.A.","Iqbal Z.","Cayabyab A.","Hung W.-Y.","Getzoff E.D.","Hu P.","Herzfeldt B.","Roos R.P.","Warner C.","Deng G.","Soriano E.","Smyth C.","Parge H.E.","Ahmed A.","Roses A.D.","Hallewell R.A.","Pericak-Vance M.A.","Siddique T."],"citationCrossReferences":[{"database":"PubMed","id":"8351519"},{"database":"DOI","id":"10.1126/science.8351519"}],"title":"Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.","publicationDate":"1993","journal":"Science","firstPage":"1047","lastPage":"1051","volume":"261"},"referencePositions":["VARIANTS ALS1 VAL-5; ARG-38; VAL-39; ASP-42; SER-42; ARG-44; ARG-86; ALA-94; CYS-94; GLY-101; VAL-107; THR-114; PHE-145 AND GLY-149"]},{"referenceNumber":58,"citation":{"id":"8179602","citationType":"journal article","authors":["Nakano R.","Sato S.","Inuzuka T.","Sakimura K.","Mishina M.","Takahashi H.","Ikuta F.","Honma Y.","Fujii J.","Taniguchi N.","Tsuji S."],"citationCrossReferences":[{"database":"PubMed","id":"8179602"},{"database":"DOI","id":"10.1006/bbrc.1994.1506"}],"title":"A novel mutation in Cu/Zn superoxide dismutase gene in Japanese familial amyotrophic lateral sclerosis.","publicationDate":"1994","journal":"Biochem. Biophys. Res. Commun.","firstPage":"695","lastPage":"703","volume":"200"},"referencePositions":["VARIANT ALS1 THR-5"]},{"referenceNumber":59,"citation":{"id":"7980516","citationType":"journal article","authors":["Hirano M.","Fujii J.","Nagai Y.","Sonobe M.","Okamoto K.","Araki H.","Taniguchi N.","Ueno S."],"citationCrossReferences":[{"database":"PubMed","id":"7980516"},{"database":"DOI","id":"10.1006/bbrc.1994.2497"}],"title":"A new variant Cu/Zn superoxide dismutase (Val7-->Glu) deduced from lymphocyte mRNA sequences from Japanese patients with familial amyotrophic lateral sclerosis.","publicationDate":"1994","journal":"Biochem. Biophys. Res. Commun.","firstPage":"572","lastPage":"577","volume":"204"},"referencePositions":["VARIANT ALS1 GLU-8"]},{"referenceNumber":60,"citation":{"id":"8069312","citationType":"journal article","authors":["Jones C.T.","Swinger R.J.","Brock D.J.H."],"citationCrossReferences":[{"database":"PubMed","id":"8069312"},{"database":"DOI","id":"10.1093/hmg/3.4.649"}],"title":"Identification of a novel SOD1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of Ile113Thr in three others.","publicationDate":"1994","journal":"Hum. Mol. Genet.","firstPage":"649","lastPage":"650","volume":"3"},"referencePositions":["VARIANT ALS1 LYS-22"]},{"referenceNumber":61,"citation":{"id":"7951252","citationType":"journal article","authors":["Esteban J.","Rosen D.R.","Bowling A.C.","Sapp P.","McKenna-Yasek D.","O'Regan J.P.","Beal M.F.","Horvitz H.R.","Brown R.H. Jr."],"citationCrossReferences":[{"database":"PubMed","id":"7951252"},{"database":"DOI","id":"10.1093/hmg/3.6.997"}],"title":"Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis.","publicationDate":"1994","journal":"Hum. Mol. Genet.","firstPage":"997","lastPage":"998","volume":"3"},"referencePositions":["VARIANTS ALS1 ASP-94 AND THR-113"]},{"referenceNumber":62,"citation":{"id":"7881433","citationType":"journal article","authors":["Kostrzewa M.","Burck-Lehmann U.","Mueller U."],"citationCrossReferences":[{"database":"PubMed","id":"7881433"},{"database":"DOI","id":"10.1093/hmg/3.12.2261"}],"title":"Autosomal dominant amyotrophic lateral sclerosis: a novel mutation in the Cu/Zn superoxide dismutase-1 gene.","publicationDate":"1994","journal":"Hum. Mol. Genet.","firstPage":"2261","lastPage":"2262","volume":"3"},"referencePositions":["VARIANT ALS1 GLY-116"]},{"referenceNumber":63,"citation":{"id":"7836951","citationType":"journal article","authors":["Aoki M.","Ogasawara M.","Matsubara Y.","Narisawa K.","Nakamura S.","Itoyama Y.","Abe K."],"citationCrossReferences":[{"database":"PubMed","id":"7836951"},{"database":"DOI","id":"10.1016/0022-510x(94)90097-3"}],"title":"Familial amyotrophic lateral sclerosis (ALS) in Japan associated with H46R mutation in Cu/Zn superoxide dismutase gene: a possible new subtype of familial ALS.","publicationDate":"1994","journal":"J. Neurol. Sci.","firstPage":"77","lastPage":"83","volume":"126"},"referencePositions":["VARIANT ALS1 ARG-47"]},{"referenceNumber":64,"citation":{"id":"7997024","citationType":"journal article","authors":["Suthers G.","Laing N.","Wilton S.","Dorosz S.","Waddy H."],"citationCrossReferences":[{"database":"PubMed","id":"7997024"},{"database":"DOI","id":"10.1016/s0140-6736(94)92913-0"}],"title":"'Sporadic' motoneuron disease due to familial SOD1 mutation with low penetrance.","publicationDate":"1994","journal":"Lancet","firstPage":"1773","lastPage":"1773","volume":"344"},"referencePositions":["VARIANT ALS1 THR-114"]},{"referenceNumber":65,"citation":{"id":"7870076","citationType":"journal article","authors":["Jones C.T.","Shaw P.J.","Chari G.","Brock D.J."],"citationCrossReferences":[{"database":"PubMed","id":"7870076"},{"database":"DOI","id":"10.1006/mcpr.1994.1046"}],"title":"Identification of a novel exon 4 SOD1 mutation in a sporadic amyotrophic lateral sclerosis patient.","publicationDate":"1994","journal":"Mol. Cell. Probes","firstPage":"329","lastPage":"330","volume":"8"},"referencePositions":["VARIANT ALS1 ASN-102"]},{"referenceNumber":66,"citation":{"id":"7887412","citationType":"journal article","authors":["Pramatarova A.","Figlewicz D.A.","Krizus A.","Han F.Y.","Ceballos-Picot I.","Nicole A.","Dib M.","Meininger V.","Brown R.H. Jr.","Rouleau G.A."],"citationCrossReferences":[{"database":"PubMed","id":"7887412"}],"title":"Identification of new mutations in the Cu/Zn superoxide dismutase gene of patients with familial amyotrophic lateral sclerosis.","publicationDate":"1995","journal":"Am. J. Hum. Genet.","firstPage":"592","lastPage":"596","volume":"56"},"referencePositions":["VARIANTS ALS1 VAL-5; ARG-38; THR-114; LYS-140; PHE-145 AND THR-150"]},{"referenceNumber":67,"citation":{"id":"7795609","citationType":"journal article","authors":["Ikeda M.","Abe K.","Aoki M.","Ogasawara M.","Kameya T.","Watanabe M.","Shoji M.","Hirai S.","Itoyama Y."],"citationCrossReferences":[{"database":"PubMed","id":"7795609"},{"database":"DOI","id":"10.1093/hmg/4.3.491"}],"title":"A novel point mutation in the Cu/Zn superoxide dismutase gene in a patient with familial amyotrophic lateral sclerosis.","publicationDate":"1995","journal":"Hum. Mol. Genet.","firstPage":"491","lastPage":"492","volume":"4"},"referencePositions":["VARIANT ALS1 ILE-149"]},{"referenceNumber":68,"citation":{"id":"7655468","citationType":"journal article","authors":["Yulug I.G.","Katsanis N.","de Belleroche J.","Collinge J.","Fisher E.M.C."],"citationCrossReferences":[{"database":"PubMed","id":"7655468"},{"database":"DOI","id":"10.1093/hmg/4.6.1101"}],"title":"An improved protocol for the analysis of SOD1 gene mutations, and a new mutation in exon 4.","publicationDate":"1995","journal":"Hum. Mol. Genet.","firstPage":"1101","lastPage":"1104","volume":"4"},"referencePositions":["VARIANT ALS1 GLY-102"]},{"referenceNumber":69,"citation":{"id":"7655469","citationType":"journal article","authors":["Sjaelander A.","Beckman G.","Deng H.-X.","Iqbal Z.","Tainer J.A.","Siddique T."],"citationCrossReferences":[{"database":"PubMed","id":"7655469"},{"database":"DOI","id":"10.1093/hmg/4.6.1105"}],"title":"The D90A mutation results in a polymorphism of Cu,Zn superoxide dismutase that is prevalent in northern Sweden and Finland.","publicationDate":"1995","journal":"Hum. Mol. Genet.","firstPage":"1105","lastPage":"1108","volume":"4"},"referencePositions":["VARIANT ALS1 ALA-91"]},{"referenceNumber":70,"citation":{"id":"7655471","citationType":"journal article","authors":["Deng H.-X.","Tainer J.A.","Mitsumoto H.","Ohnishi A.","He X.","Hung W.-Y.","Zhao Y.","Juneja T.","Hentati A.","Siddique T."],"citationCrossReferences":[{"database":"PubMed","id":"7655471"},{"database":"DOI","id":"10.1093/hmg/4.6.1113"}],"title":"Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis.","publicationDate":"1995","journal":"Hum. Mol. Genet.","firstPage":"1113","lastPage":"1116","volume":"4"},"referencePositions":["VARIANTS ALS1 MET-15 AND VAL-85"]},{"referenceNumber":71,"citation":{"id":"7700376","citationType":"journal article","authors":["Orrell R.","de Belleroche J.","Marklund S.","Bowe F.","Hallewell R."],"citationCrossReferences":[{"database":"PubMed","id":"7700376"},{"database":"DOI","id":"10.1038/374504a0"}],"title":"A novel SOD mutant and ALS.","publicationDate":"1995","journal":"Nature","firstPage":"504","lastPage":"505","volume":"374"},"referencePositions":["VARIANT ALS1 ARG-94"]},{"referenceNumber":72,"citation":{"id":"7647793","citationType":"journal article","authors":["Andersen P.M.","Nilsson P.","Ala-Hurula V.","Keraenen M.-L.","Tarvainen I.","Haltia T.","Nilsson L.","Binzer M.","Forsgren L.","Marklund S.L."],"citationCrossReferences":[{"database":"PubMed","id":"7647793"},{"database":"DOI","id":"10.1038/ng0595-61"}],"title":"Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase.","publicationDate":"1995","journal":"Nat. Genet.","firstPage":"61","lastPage":"66","volume":"10"},"referencePositions":["VARIANT ALS1 ALA-91"]},{"referenceNumber":73,"citation":{"id":"7501156","citationType":"journal article","authors":["Ikeda M.","Abe K.","Aoki M.","Sahara M.","Watanabe M.","Shoji M.","St George-Hyslop P.H.","Hirai S.","Itoyama Y."],"citationCrossReferences":[{"database":"PubMed","id":"7501156"},{"database":"DOI","id":"10.1212/wnl.45.11.2038"}],"title":"Variable clinical symptoms in familial amyotrophic lateral sclerosis with a novel point mutation in the Cu/Zn superoxide dismutase gene.","publicationDate":"1995","journal":"Neurology","firstPage":"2038","lastPage":"2042","volume":"45"},"referencePositions":["VARIANT ALS1 PHE-105"]},{"referenceNumber":74,"citation":{"id":"7496169","citationType":"journal article","authors":["Sapp P.C.","Rosen D.R.","Hosler B.A.","Esteban J.","McKenna-Yasek D.","O'Regan J.P.","Horvitz H.R.","Brown R.H. Jr."],"citationCrossReferences":[{"database":"PubMed","id":"7496169"},{"database":"DOI","id":"10.1016/0960-8966(95)00007-a"}],"title":"Identification of three novel mutations in the gene for Cu/Zn superoxide dismutase in patients with familial amyotrophic lateral sclerosis.","publicationDate":"1995","journal":"Neuromuscul. Disord.","firstPage":"353","lastPage":"357","volume":"5"},"referencePositions":["VARIANTS ALS1 SER-145; THR-146 AND PHE-LEU-GLN-119 INS"]},{"referenceNumber":75,"citation":{"id":"8875253","citationType":"journal article","authors":["Siddique T.","Deng H.X."],"citationCrossReferences":[{"database":"PubMed","id":"8875253"},{"database":"DOI","id":"10.1093/hmg/5.supplement_1.1465"}],"title":"Genetics of amyotrophic lateral sclerosis.","publicationDate":"1996","journal":"Hum. Mol. Genet.","firstPage":"1465","lastPage":"1470","volume":"5"},"referencePositions":["VARIANTS ALS1 LYS-101 AND ARG-147"]},{"referenceNumber":76,"citation":{"id":"8938700","citationType":"journal article","authors":["Hosler B.A.","Nicholson G.A.","Sapp P.C.","Chin W.","Orrell R.W.","de Belleroche J.S.","Esteban J.","Hayward L.J.","Mckenna-Yasek D.","Yeung L.","Cherryson A.K.","Dench J.E.","Wilton S.D.","Laing N.G.","Horvitz R.H.","Brown R.H. Jr."],"citationCrossReferences":[{"database":"PubMed","id":"8938700"},{"database":"DOI","id":"10.1016/0960-8966(96)00353-7"}],"title":"Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis.","publicationDate":"1996","journal":"Neuromuscul. Disord.","firstPage":"361","lastPage":"366","volume":"6"},"referencePositions":["VARIANTS ALS1 VAL-94; VAL-125 AND GLU-134 DEL"]},{"referenceNumber":77,"citation":{"id":"8907321","citationType":"journal article","authors":["Morita M.","Aoki M.","Abe K.","Hasegawa T.","Sakuma R.","Onodera Y.","Ichikawa N.","Nishizawa M.","Itoyama Y."],"citationCrossReferences":[{"database":"PubMed","id":"8907321"},{"database":"DOI","id":"10.1016/0304-3940(96)12378-8"}],"title":"A novel two-base mutation in the Cu/Zn superoxide dismutase gene associated with familial amyotrophic lateral sclerosis in Japan.","publicationDate":"1996","journal":"Neurosci. Lett.","firstPage":"79","lastPage":"82","volume":"205"},"referencePositions":["VARIANT ALS1 PHE-7"]},{"referenceNumber":78,"citation":{"id":"9365366","citationType":"journal article","authors":["Andersen P.M.","Nilsson P.","Keraenen M.L.","Forsgren L.","Haegglund J.","Karlsborg M.","Ronnevi L.O.","Gredal O.","Marklund S.L."],"citationCrossReferences":[{"database":"PubMed","id":"9365366"},{"database":"DOI","id":"10.1093/brain/120.10.1723"}],"title":"Phenotypic heterogeneity in motor neuron disease patients with CuZn-superoxide dismutase mutations in Scandinavia.","publicationDate":"1997","journal":"Brain","firstPage":"1723","lastPage":"1737","volume":"120"},"referencePositions":["VARIANTS ALS1 VAL-5; GLY-15; TYR-77 AND ALA-91"]},{"referenceNumber":79,"citation":{"id":"24283821","citationType":"journal article","authors":["Orrell R.W.","Habgood J.J.","Shepherd D.I.","Donnai D.","de Belleroche J."],"citationCrossReferences":[{"database":"PubMed","id":"24283821"},{"database":"DOI","id":"10.1111/j.1468-1331.1997.tb00298.x"}],"title":"A novel mutation of SOD-1 (Gly 108 Val) in familial amyotrophic lateral sclerosis.","publicationDate":"1997","journal":"Eur. J. Neurol.","firstPage":"48","lastPage":"51","volume":"4"},"referencePositions":["VARIANT ALS1 VAL-109"]},{"referenceNumber":80,"citation":{"id":"8990014","citationType":"journal article","authors":["Watanabe M.","Aoki M.","Abe K.","Shoji M.","Lizuka T.","Ikeda Y.","Hirai S.","Kurokawa K.","Kato T.","Sasaki H.","Itoyama Y."],"citationCrossReferences":[{"database":"PubMed","id":"8990014"},{"database":"DOI","id":"10.1002/(sici)1098-1004(1997)9:1<69::aid-humu14>3.0.co;2-n"}],"title":"A novel missense point mutation (S134N) of the Cu/Zn superoxide dismutase gene in a patient with familial motor neuron disease.","publicationDate":"1997","journal":"Hum. Mutat.","firstPage":"69","lastPage":"71","volume":"9"},"referencePositions":["VARIANT ALS1 ASN-135"]},{"referenceNumber":81,"citation":{"id":"9101297","citationType":"journal article","authors":["Kawamata J.","Shimohama S.","Takano S.","Harada K.","Ueda K.","Kimura J."],"citationCrossReferences":[{"database":"PubMed","id":"9101297"},{"database":"DOI","id":"10.1002/(sici)1098-1004(1997)9:4<356::aid-humu9>3.0.co;2-3"}],"title":"Novel G16S (GGC-AGC) mutation in the SOD-1 gene in a patient with apparently sporadic young-onset amyotrophic lateral sclerosis.","publicationDate":"1997","journal":"Hum. Mutat.","firstPage":"356","lastPage":"358","volume":"9"},"referencePositions":["VARIANT ALS1 SER-17"]},{"referenceNumber":82,"citation":{"id":"9455977","citationType":"journal article","authors":["Orrell R.W.","Marklund S.L.","deBelleroche J.S."],"citationCrossReferences":[{"database":"PubMed","id":"9455977"},{"database":"DOI","id":"10.1016/s0022-510x(97)00181-0"}],"title":"Familial ALS is associated with mutations in all exons of SOD1: a novel mutation in exon 3 (Gly72Ser).","publicationDate":"1997","journal":"J. Neurol. Sci.","firstPage":"46","lastPage":"49","volume":"153"},"referencePositions":["VARIANT ALS1 SER-73"]},{"referenceNumber":83,"citation":{"id":"10732812","citationType":"journal article","authors":["Kikugawa K.","Nakano R.","Inuzuka T.","Kokubo Y.","Narita Y.","Kuzuhara S.","Yoshida S.","Tsuji S."],"citationCrossReferences":[{"database":"PubMed","id":"10732812"},{"database":"DOI","id":"10.1007/s100480050016"}],"title":"A missense mutation in the SOD1 gene in patients with amyotrophic lateral sclerosis from the Kii Peninsula and its vicinity, Japan.","publicationDate":"1997","journal":"Neurogenetics","firstPage":"113","lastPage":"115","volume":"1"},"referencePositions":["VARIANT ALS1 THR-114"]},{"referenceNumber":84,"citation":{"id":"9131652","citationType":"journal article","authors":["Bereznai B.","Winkler A.","Borasio G.D.","Gasser T."],"citationCrossReferences":[{"database":"PubMed","id":"9131652"},{"database":"DOI","id":"10.1016/s0960-8966(96)00419-1"}],"title":"A novel SOD1 mutation in an Austrian family with amyotrophic lateral sclerosis.","publicationDate":"1997","journal":"Neuromuscul. Disord.","firstPage":"113","lastPage":"116","volume":"7"},"referencePositions":["VARIANT ALS1 GLN-9"]},{"referenceNumber":85,"citation":{"id":"9706719","citationType":"journal article","authors":["Boukaftane Y.","Khoris J.","Moulard B.","Salachas F.","Meininger V.","Malafosse A.","Camu W.","Rouleau G.A."],"citationCrossReferences":[{"database":"PubMed","id":"9706719"},{"database":"DOI","id":"10.1017/s0317167100034004"}],"title":"Identification of six novel SOD1 gene mutations in familial amyotrophic lateral sclerosis.","publicationDate":"1998","journal":"Can. J. Neurol. Sci.","firstPage":"192","lastPage":"196","volume":"25"},"referencePositions":["VARIANTS ALS1 GLY-22; ARG-39; LYS-50; ARG-68 AND PHE-85"]},{"referenceNumber":86,"citation":{"id":"CI-CEV55R8SONF33","citationType":"journal article","authors":["Morita M.","Abe K.","Takahashi M.","Onodera Y.","Okumura H.","Niino M.","Tashiro K.","Nakano I.","Itoyama Y."],"citationCrossReferences":[{"database":"DOI","id":"10.1046/j.1468-1331.1998.540389.x"}],"title":"A novel mutation Asp90Val in the SOD1 gene associated with Japanese familial ALS.","publicationDate":"1998","journal":"Eur. J. Neurol.","firstPage":"389","lastPage":"392","volume":"5"},"referencePositions":["VARIANT ALS1 VAL-91"]},{"referenceNumber":87,"citation":{"id":"9696308","citationType":"journal article","authors":["Nakanishi T.","Kishikawa M.","Miyazaki A.","Shimizu A.","Ogawa Y.","Sakoda S.","Ohi T.","Shoji H."],"citationCrossReferences":[{"database":"PubMed","id":"9696308"},{"database":"DOI","id":"10.1016/s0165-0270(98)00012-0"}],"title":"Simple and defined method to detect the SOD-1 mutants from patients with familial amyotrophic lateral sclerosis by mass spectrometry.","publicationDate":"1998","journal":"J. Neurosci. Methods","firstPage":"41","lastPage":"44","volume":"81"},"referencePositions":["VARIANT ALS1 SER-5"]},{"referenceNumber":88,"citation":{"id":"10400992","citationType":"journal article","authors":["Ratovitski T.","Corson L.B.","Strain J.","Wong P.","Cleveland D.W.","Culotta V.C.","Borchelt D.R."],"citationCrossReferences":[{"database":"PubMed","id":"10400992"},{"database":"DOI","id":"10.1093/hmg/8.8.1451"}],"title":"Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.","publicationDate":"1999","journal":"Hum. Mol. Genet.","firstPage":"1451","lastPage":"1460","volume":"8"},"referencePositions":["CHARACTERIZATION OF VARIANTS ALS1 VAL-5; ARG-38; ARG-47; GLN-49; ARG-86 AND THR-114"]},{"referenceNumber":89,"citation":{"id":"10430435","citationType":"journal article","authors":["Penco S.","Schenone A.","Bordo D.","Bolognesi M.","Abbruzzese M.","Bugiani O.","Ajmar F.","Garre C."],"citationCrossReferences":[{"database":"PubMed","id":"10430435"},{"database":"DOI","id":"10.1212/wnl.53.2.404"}],"title":"A SOD1 gene mutation in a patient with slowly progressing familial ALS.","publicationDate":"1999","journal":"Neurology","firstPage":"404","lastPage":"406","volume":"53"},"referencePositions":["VARIANT ALS1 ARG-13"]},{"referenceNumber":90,"citation":{"id":"CI-1429TR8AP60PC","citationType":"journal article","authors":["Penco S.","Schenone A.","Bordo D.","Bolognesi M.","Abbruzzese M.","Bugiani O.","Ajmar F.","Garre C."],"publicationDate":"2001","journal":"Neurology","firstPage":"1146","lastPage":"1146","volume":"57"},"referencePositions":["ERRATUM OF PUBMED:10430435"]},{"referenceNumber":91,"citation":{"id":"11535232","citationType":"journal article","authors":["Murakami T.","Warita H.","Hayashi T.","Sato K.","Manabe Y.","Mizuno S.","Yamane K.","Abe K."],"citationCrossReferences":[{"database":"PubMed","id":"11535232"},{"database":"DOI","id":"10.1016/s0022-510x(01)00558-5"}],"title":"A novel SOD1 gene mutation in familial ALS with low penetrance in females.","publicationDate":"2001","journal":"J. Neurol. Sci.","firstPage":"45","lastPage":"47","volume":"189"},"referencePositions":["VARIANT ALS1 SER-127"]},{"referenceNumber":92,"citation":{"id":"11369193","citationType":"journal article","authors":["Gellera C.","Castellotti B.","Riggio M.C.","Silani V.","Morandi L.","Testa D.","Casali C.","Taroni F.","Di Donato S.","Zeviani M.","Mariotti C."],"citationCrossReferences":[{"database":"PubMed","id":"11369193"},{"database":"DOI","id":"10.1016/s0960-8966(00)00215-7"}],"title":"Superoxide dismutase gene mutations in Italian patients with familial and sporadic amyotrophic lateral sclerosis: identification of three novel missense mutations.","publicationDate":"2001","journal":"Neuromuscul. Disord.","firstPage":"404","lastPage":"410","volume":"11"},"referencePositions":["VARIANT ALS1 CYS-46"]},{"referenceNumber":93,"citation":{"id":"12402272","citationType":"journal article","authors":["Alexander M.D.","Traynor B.J.","Miller N.","Corr B.","Frost E.","McQuaid S.","Brett F.M.","Green A.","Hardiman O."],"citationCrossReferences":[{"database":"PubMed","id":"12402272"},{"database":"DOI","id":"10.1002/ana.10369"}],"title":"'True' sporadic ALS associated with a novel SOD-1 mutation.","publicationDate":"2002","journal":"Ann. Neurol.","firstPage":"680","lastPage":"683","volume":"52"},"referencePositions":["VARIANT ALS1 ARG-81"]},{"referenceNumber":94,"citation":{"id":"12145308","citationType":"journal article","authors":["Niwa J.","Ishigaki S.","Hishikawa N.","Yamamoto M.","Doyu M.","Murata S.","Tanaka K.","Taniguchi N.","Sobue G."],"citationCrossReferences":[{"database":"PubMed","id":"12145308"},{"database":"DOI","id":"10.1074/jbc.m206559200"}],"title":"Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"36793","lastPage":"36798","volume":"277"},"referencePositions":["CHARACTERIZATION OF VARIANTS ALS1 ARG-38; ARG-47; ARG-86 AND ALA-94","INTERACTION WITH RNF19A","UBIQUITINATION"]},{"referenceNumber":95,"citation":{"id":"12210393","citationType":"journal article","authors":["Garcia-Redondo A.","Bustos F.","Juan Y Seva B.","Del Hoyo P.","Jimenez S.","Campos Y.","Martin M.A.","Rubio J.C.","Canadillas F.","Arenas J.","Esteban J."],"citationCrossReferences":[{"database":"PubMed","id":"12210393"},{"database":"DOI","id":"10.1002/mus.10193"}],"title":"Molecular analysis of the superoxide dismutase 1 gene in Spanish patients with sporadic or familial amyotrophic lateral sclerosis.","publicationDate":"2002","journal":"Muscle Nerve","firstPage":"274","lastPage":"278","volume":"26"},"referencePositions":["VARIANTS ALS1 ARG-38; SER-66 AND MET-113"]},{"referenceNumber":96,"citation":{"id":"14506936","citationType":"journal article","authors":["Andersen P.M.","Sims K.B.","Xin W.W.","Kiely R.","O'Neill G.","Ravits J.","Pioro E.","Harati Y.","Brower R.D.","Levine J.S.","Heinicke H.U.","Seltzer W.","Boss M.","Brown R.H. Jr."],"citationCrossReferences":[{"database":"PubMed","id":"14506936"},{"database":"DOI","id":"10.1080/14660820310011700"}],"title":"Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes.","publicationDate":"2003","journal":"Amyotroph. Lateral Scler.","firstPage":"62","lastPage":"73","volume":"4"},"referencePositions":["VARIANTS ALS1 VAL-9; CYS-21; LEU-23; ARG-49; ARG-55; ALA-88; THR-90; MET-98; LEU-106; ALA-115; LEU-119; GLY-125 AND ARG-148"]},{"referenceNumber":97,"citation":{"id":"18552350","citationType":"journal article","authors":["Furukawa Y.","Kaneko K.","Yamanaka K.","O'Halloran T.V.","Nukina N."],"citationCrossReferences":[{"database":"PubMed","id":"18552350"},{"database":"DOI","id":"10.1074/jbc.m802083200"}],"title":"Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"24167","lastPage":"24176","volume":"283"},"referencePositions":["CHARACTERIZATION OF VARIANTS ALS1 ARG-38; ARG-86 AND ARG-94","MUTAGENESIS OF CYS-7; 51-PHE-GLY-52; CYS-58; HIS-81; ASP-84; CYS-112 AND CYS-147","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":98,"citation":{"id":"18301754","citationType":"journal article","authors":["Banci L.","Bertini I.","Boca M.","Girotto S.","Martinelli M.","Valentine J.S.","Vieru M."],"citationCrossReferences":[{"database":"PubMed","id":"18301754"},{"database":"DOI","id":"10.1371/journal.pone.0001677"}],"title":"SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization.","publicationDate":"2008","journal":"PLoS ONE","firstPage":"E1677","lastPage":"E1677","volume":"3"},"referencePositions":["CHARACTERIZATION OF VARIANTS ALS1 ARG-55; ALA-91; ALA-94; ASP-94; MET-98 AND PHE-145"]},{"referenceNumber":99,"citation":{"id":"19741096","citationType":"journal article","authors":["Yonashiro R.","Sugiura A.","Miyachi M.","Fukuda T.","Matsushita N.","Inatome R.","Ogata Y.","Suzuki T.","Dohmae N.","Yanagi S."],"citationCrossReferences":[{"database":"PubMed","id":"19741096"},{"database":"DOI","id":"10.1091/mbc.e09-02-0112"}],"title":"Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.","publicationDate":"2009","journal":"Mol. Biol. Cell","firstPage":"4524","lastPage":"4530","volume":"20"},"referencePositions":["CHARACTERIZATION OF VARIANTS ALS1 ARG-86 AND ALA-94","UBIQUITINATION BY MARCH5","SUBCELLULAR LOCATION"]},{"referenceNumber":100,"citation":{"id":"20460594","citationType":"journal article","authors":["Felbecker A.","Camu W.","Valdmanis P.N.","Sperfeld A.D.","Waibel S.","Steinbach P.","Rouleau G.A.","Ludolph A.C.","Andersen P.M."],"citationCrossReferences":[{"database":"PubMed","id":"20460594"},{"database":"DOI","id":"10.1136/jnnp.2009.192310"}],"title":"Four familial ALS pedigrees discordant for two SOD1 mutations: are all SOD1 mutations pathogenic?","publicationDate":"2010","journal":"J. Neurol. Neurosurg. Psych.","firstPage":"572","lastPage":"577","volume":"81"},"referencePositions":["VARIANTS ALS1 ALA-91 AND LYS-101"]},{"referenceNumber":101,"citation":{"id":"21247266","citationType":"journal article","authors":["del Grande A.","Luigetti M.","Conte A.","Mancuso I.","Lattante S.","Marangi G.","Stipa G.","Zollino M.","Sabatelli M."],"citationCrossReferences":[{"database":"PubMed","id":"21247266"},{"database":"DOI","id":"10.3109/17482968.2011.551939"}],"title":"A novel L67P SOD1 mutation in an Italian ALS patient.","publicationDate":"2011","journal":"Amyotroph. Lateral Scler.","firstPage":"150","lastPage":"152","volume":"12"},"referencePositions":["VARIANT ALS1 PRO-68"]},{"referenceNumber":102,"citation":{"id":"21220647","citationType":"journal article","authors":["Chio A.","Borghero G.","Pugliatti M.","Ticca A.","Calvo A.","Moglia C.","Mutani R.","Brunetti M.","Ossola I.","Marrosu M.G.","Murru M.R.","Floris G.","Cannas A.","Parish L.D.","Cossu P.","Abramzon Y.","Johnson J.O.","Nalls M.A.","Arepalli S.","Chong S.","Hernandez D.G.","Traynor B.J.","Restagno G."],"citationCrossReferences":[{"database":"PubMed","id":"21220647"},{"database":"DOI","id":"10.1001/archneurol.2010.352"}],"title":"Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene.","publicationDate":"2011","journal":"Arch. Neurol.","firstPage":"594","lastPage":"598","volume":"68"},"referencePositions":["VARIANT ALS1 GLY-96"]},{"referenceNumber":103,"citation":{"id":"27604643","citationType":"journal article","authors":["Hou L.","Jiao B.","Xiao T.","Zhou L.","Zhou Z.","Du J.","Yan X.","Wang J.","Tang B.","Shen L."],"citationCrossReferences":[{"database":"PubMed","id":"27604643"},{"database":"DOI","id":"10.1038/srep32478"}],"title":"Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.","publicationDate":"2016","journal":"Sci. Rep.","firstPage":"32478","lastPage":"32478","volume":"6"},"referencePositions":["VARIANTS ALS1 SER-87; ALA-88; ASN-102; GLY-102 AND TYR-112"]},{"referenceNumber":104,"citation":{"id":"31086828","citationType":"journal article","authors":["Kuuluvainen L.","Kaivola K.","Moenkaere S.","Laaksovirta H.","Jokela M.","Udd B.","Valori M.","Pasanen P.","Paetau A.","Traynor B.J.","Stone D.J.","Schleutker J.","Poeyhoenen M.","Tienari P.J.","Myllykangas L."],"citationCrossReferences":[{"database":"PubMed","id":"31086828"},{"database":"DOI","id":"10.1212/nxg.0000000000000335"}],"title":"Oligogenic basis of sporadic ALS: The example of SOD1 p.Ala90Val mutation.","publicationDate":"2019","journal":"Neurol. Genet.","firstPage":"e335","lastPage":"e335","volume":"5"},"referencePositions":["VARIANT ALS1 VAL-90"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L44139","properties":[{"key":"ProteinId","value":"AAB05662.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L44135","properties":[{"key":"ProteinId","value":"AAB05662.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L44136","properties":[{"key":"ProteinId","value":"AAB05662.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L44137","properties":[{"key":"ProteinId","value":"AAB05662.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L44139","properties":[{"key":"ProteinId","value":"AAB05661.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L44135","properties":[{"key":"ProteinId","value":"AAB05661.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L44136","properties":[{"key":"ProteinId","value":"AAB05661.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L44137","properties":[{"key":"ProteinId","value":"AAB05661.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X02317","properties":[{"key":"ProteinId","value":"CAA26182.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X01780","properties":[{"key":"ProteinId","value":"CAA25915.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X01781","properties":[{"key":"ProteinId","value":"CAA25916.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X01782","properties":[{"key":"ProteinId","value":"CAA25917.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X01783","properties":[{"key":"ProteinId","value":"CAA25918.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X01784","properties":[{"key":"ProteinId","value":"CAA25919.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY049787","properties":[{"key":"ProteinId","value":"AAL15444.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY450286","properties":[{"key":"ProteinId","value":"AAR21563.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF151142","properties":[{"key":"ProteinId","value":"ABL96616.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK312116","properties":[{"key":"ProteinId","value":"BAG35052.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR450355","properties":[{"key":"ProteinId","value":"CAG29351.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR541742","properties":[{"key":"ProteinId","value":"CAG46542.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT006676","properties":[{"key":"ProteinId","value":"AAP35322.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY835629","properties":[{"key":"ProteinId","value":"AAV80422.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP000253","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471079","properties":[{"key":"ProteinId","value":"EAX09889.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471079","properties":[{"key":"ProteinId","value":"EAX09890.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC001034","properties":[{"key":"ProteinId","value":"AAH01034.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L46374","properties":[{"key":"ProteinId","value":"AAB59626.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L46375","properties":[{"key":"ProteinId","value":"AAB59627.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L44746","properties":[{"key":"ProteinId","value":"AAC41773.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X95228","properties":[{"key":"ProteinId","value":"CAA64520.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS33536.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A22703","properties":[{"key":"EntryName","value":"DSHUCZ"}]},{"database":"RefSeq","id":"NP_000445.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000454.5"}]},{"database":"PDB","id":"1AZV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"1BA9","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"1DSW","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"1FUN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=2-154"}]},{"database":"PDB","id":"1HL4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"1HL5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/S=2-154"}]},{"database":"PDB","id":"1KMG","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"1L3N","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"1MFM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.02 A"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"1N18","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-154"}]},{"database":"PDB","id":"1N19","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A/B=1-154"}]},{"database":"PDB","id":"1OEZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"W/X/Y/Z=2-154"}]},{"database":"PDB","id":"1OZT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"G/H/I/J/K/L/M/N=2-154"}]},{"database":"PDB","id":"1OZU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"1P1V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B/C=2-154"}]},{"database":"PDB","id":"1PTZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"1PU0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=2-154"}]},{"database":"PDB","id":"1RK7","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"1SOS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=2-154"}]},{"database":"PDB","id":"1SPD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"1UXL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=2-154"}]},{"database":"PDB","id":"1UXM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=2-154"}]},{"database":"PDB","id":"2AF2","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"2C9S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.24 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2C9U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.24 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2C9V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.07 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2GBT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"2GBU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"2GBV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=2-154"}]},{"database":"PDB","id":"2LU5","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"2MP3","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-126"}]},{"database":"PDB","id":"2NAM","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"2NNX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"2R27","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=1-154"}]},{"database":"PDB","id":"2V0A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.15 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2VR6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2VR7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2VR8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.36 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2WKO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.97 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2WYT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.00 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2WYZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2WZ0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.72 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2WZ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2WZ6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"2XJK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"2XJL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"2ZKW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=1-154"}]},{"database":"PDB","id":"2ZKX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.72 A"},{"key":"Chains","value":"A/B/C/D=1-154"}]},{"database":"PDB","id":"2ZKY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-154"}]},{"database":"PDB","id":"3CQP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"3CQQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"3ECU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"3ECV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"3ECW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"3GQF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D/E/F=2-154"}]},{"database":"PDB","id":"3GTV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=2-90"}]},{"database":"PDB","id":"3GZO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=2-154"}]},{"database":"PDB","id":"3GZP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"3GZQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"3H2P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"3H2Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"3HFF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"3K91","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"3KH3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=2-154"}]},{"database":"PDB","id":"3KH4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B/C/D/E/F=2-154"}]},{"database":"PDB","id":"3LTV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A/B/C/D/E/F=91-154"}]},{"database":"PDB","id":"3QQD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"3RE0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.28 A"},{"key":"Chains","value":"A/B/C/D=2-154"}]},{"database":"PDB","id":"3T5W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/D/E/F/G/H/I/J/K/L/M=2-154"}]},{"database":"PDB","id":"4A7G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.24 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"4A7Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.22 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"4A7S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.06 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"4A7T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"4A7U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.98 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"4A7V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.00 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"4B3E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-154"}]},{"database":"PDB","id":"4BCY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.27 A"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"4BCZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.93 A"},{"key":"Chains","value":"A/B=2-49, A/B=83-124, A/B=141-154"}]},{"database":"PDB","id":"4BD4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.78 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I=2-49, A/B/C/D/E/F/G/H/I=83-124, A/B/C/D/E/F/G/H/I=141-154"}]},{"database":"PDB","id":"4FF9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"4MCM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=2-154"}]},{"database":"PDB","id":"4MCN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"4NIN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=102-108"}]},{"database":"PDB","id":"4NIO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A=148-154"}]},{"database":"PDB","id":"4NIP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=148-154"}]},{"database":"PDB","id":"4OH2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.38 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=2-154"}]},{"database":"PDB","id":"4XCR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"5DLI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=29-39"}]},{"database":"PDB","id":"5IIW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=29-39"}]},{"database":"PDB","id":"5J07","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=14-49, A/B=84-124, A/B=141-154"}]},{"database":"PDB","id":"5J0C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=29-49, A/B=84-124, A/B=141-154"}]},{"database":"PDB","id":"5J0F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.25 A"},{"key":"Chains","value":"A/B=2-49"}]},{"database":"PDB","id":"5J0G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=2-124"}]},{"database":"PDB","id":"5K02","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=2-154"}]},{"database":"PDB","id":"5O3Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"5O40","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"5U9M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A/C=2-154"}]},{"database":"PDB","id":"5WMJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=31-36"}]},{"database":"PDB","id":"5WOR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.77 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=29-39"}]},{"database":"PDB","id":"5YTO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-154"}]},{"database":"PDB","id":"5YTU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-154"}]},{"database":"PDB","id":"5YUL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-154"}]},{"database":"PDB","id":"6A9O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-154"}]},{"database":"PDB","id":"6B79","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=29-39"}]},{"database":"PDB","id":"6DTK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/C/E/G/I=1-154"}]},{"database":"PDB","id":"6FFK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.94 A"},{"key":"Chains","value":"A/B/D/F=2-154"}]},{"database":"PDB","id":"6FLH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"6FOI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/D/F/G/I/K/M/O/Q/S/U/W=2-154"}]},{"database":"PDB","id":"6FOL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"B/C/F/G=2-154"}]},{"database":"PDB","id":"6FON","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"B/D=2-154"}]},{"database":"PDB","id":"6FP6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/C/E/G/I/K/M/O/Q/S/U/W=2-154"}]},{"database":"PDB","id":"6SPA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/C/E/G/J/L=2-154"}]},{"database":"PDB","id":"6SPH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A/C/E/G/J/L=2-154"}]},{"database":"PDB","id":"6SPI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-154"}]},{"database":"PDB","id":"6SPJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.97 A"},{"key":"Chains","value":"A/B/E/F/I/J=2-154"}]},{"database":"PDB","id":"6SPK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.77 A"},{"key":"Chains","value":"A/B/E/F/I/J=2-154"}]},{"database":"PDB","id":"6Z3V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.25 A"},{"key":"Chains","value":"AAA/BBB=2-154"}]},{"database":"PDB","id":"6Z4G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"AAA/BBB=2-154"}]},{"database":"PDB","id":"6Z4H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"AAA/BBB=2-154"}]},{"database":"PDB","id":"6Z4I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"AAA/FFF=2-154"}]},{"database":"PDB","id":"6Z4J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"AAA/BBB=2-154"}]},{"database":"PDB","id":"6Z4K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"AAA/BBB=2-154"}]},{"database":"PDB","id":"6Z4L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"AAA/BBB=2-154"}]},{"database":"PDB","id":"6Z4M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"AAA/BBB=2-154"}]},{"database":"PDB","id":"6Z4O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"AAA/BBB=2-154"}]},{"database":"PDB","id":"7CJV","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"7CJW","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"7FB6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=1-154"}]},{"database":"PDB","id":"7FB9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-154"}]},{"database":"PDB","id":"7NXX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.19 A"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"7T8E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"7T8F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"7T8G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"7T8H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/F=2-154"}]},{"database":"PDB","id":"7VZF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"A/B/C=1-154"}]},{"database":"PDB","id":"7XX3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-154"}]},{"database":"PDB","id":"8CCX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A/F=1-154"}]},{"database":"PDB","id":"8GSQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D/F/I/J=1-154"}]},{"database":"PDB","id":"8IHU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.97 A"},{"key":"Chains","value":"A/B/C=1-154"}]},{"database":"PDB","id":"8IHV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.11 A"},{"key":"Chains","value":"A/B/C=1-154"}]},{"database":"PDB","id":"8K33","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.13 A"},{"key":"Chains","value":"A/C/E/G/I/K/L/N/P/U/W/Y=2-154"}]},{"database":"PDB","id":"8K3A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.74 A"},{"key":"Chains","value":"A=2-154"}]},{"database":"PDB","id":"8K3L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/C/E/G=2-154"}]},{"database":"PDB","id":"8Q6M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.77 A"},{"key":"Chains","value":"A/B=1-154"}]},{"database":"PDB","id":"8YAF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.28 A"},{"key":"Chains","value":"A/D/H/L/P/T=2-154"}]},{"database":"PDB","id":"8YAT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.94 A"},{"key":"Chains","value":"A/E/I/M=2-154"}]},{"database":"PDB","id":"8YD3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.96 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-154"}]},{"database":"PDB","id":"9IYD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.09 A"},{"key":"Chains","value":"A/B/C=1-154"}]},{"database":"PDB","id":"9IYJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.92 A"},{"key":"Chains","value":"A/B/C=2-154"}]},{"database":"PDB","id":"9IYK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.34 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-154"}]},{"database":"PDB","id":"9JBO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.39 A"},{"key":"Chains","value":"A/B/C=1-154"}]},{"database":"PDB","id":"9JBP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.18 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-154"}]},{"database":"PDB","id":"9LI1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.74 A"},{"key":"Chains","value":"A/B/C=1-154"}]},{"database":"PDB","id":"9MIL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=29-40"}]},{"database":"PDB","id":"9XJ0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"PDB","id":"9XJI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.37 A"},{"key":"Chains","value":"A/B=2-154"}]},{"database":"AlphaFoldDB","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32227","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35459","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35460","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60996","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60998","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61321","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61322","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-63109","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112530","properties":[{"key":"Interactions","value":"444"}]},{"database":"ComplexPortal","id":"CPX-21824","properties":[{"key":"EntryName","value":"CCS-SOD1, oxidative stress response complex"}]},{"database":"ComplexPortal","id":"CPX-2897","properties":[{"key":"EntryName","value":"[Cu-Zn] Superoxide dismutase complex"}]},{"database":"DIP","id":"DIP-44941N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P00441","properties":[{"key":"Number of interactors","value":"1586"}]},{"database":"IntAct","id":"P00441","properties":[{"key":"Interactions","value":"344"}]},{"database":"NDEx","id":"IQUERY-CP-SOD1","properties":[{"key":"Evidences","value":"17 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000270142","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2354","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB01629","properties":[{"key":"GenericName","value":"5-fluorouridine"}]},{"database":"DrugBank","id":"DB14511","properties":[{"key":"GenericName","value":"Acetate"}]},{"database":"DrugBank","id":"DB05874","properties":[{"key":"GenericName","value":"AEOL-10150"}]},{"database":"DrugBank","id":"DB14001","properties":[{"key":"GenericName","value":"alpha-Tocopherol succinate"}]},{"database":"DrugBank","id":"DB17641","properties":[{"key":"GenericName","value":"Ammonium tetrathiomolybdate"}]},{"database":"DrugBank","id":"DB09096","properties":[{"key":"GenericName","value":"Benzoyl peroxide"}]},{"database":"DrugBank","id":"DB09061","properties":[{"key":"GenericName","value":"Cannabidiol"}]},{"database":"DrugBank","id":"DB00958","properties":[{"key":"GenericName","value":"Carboplatin"}]},{"database":"DrugBank","id":"DB00515","properties":[{"key":"GenericName","value":"Cisplatin"}]},{"database":"DrugBank","id":"DB09130","properties":[{"key":"GenericName","value":"Copper"}]},{"database":"DrugBank","id":"DB14002","properties":[{"key":"GenericName","value":"D-alpha-Tocopherol acetate"}]},{"database":"DrugBank","id":"DB00988","properties":[{"key":"GenericName","value":"Dopamine"}]},{"database":"DrugBank","id":"DB01064","properties":[{"key":"GenericName","value":"Isoprenaline"}]},{"database":"DrugBank","id":"DB14009","properties":[{"key":"GenericName","value":"Medical Cannabis"}]},{"database":"DrugBank","id":"DB14011","properties":[{"key":"GenericName","value":"Nabiximols"}]},{"database":"DrugBank","id":"DB00526","properties":[{"key":"GenericName","value":"Oxaliplatin"}]},{"database":"DrugBank","id":"DB09221","properties":[{"key":"GenericName","value":"Polaprezinc"}]},{"database":"DrugBank","id":"DB03382","properties":[{"key":"GenericName","value":"S-oxy-L-cysteine"}]},{"database":"DrugBank","id":"DB12449","properties":[{"key":"GenericName","value":"Tempol"}]},{"database":"DrugBank","id":"DB05088","properties":[{"key":"GenericName","value":"Tetrathiomolybdate"}]},{"database":"DrugBank","id":"DB14782","properties":[{"key":"GenericName","value":"Tofersen"}]},{"database":"DrugBank","id":"DB00163","properties":[{"key":"GenericName","value":"Vitamin E"}]},{"database":"DrugBank","id":"DB01593","properties":[{"key":"GenericName","value":"Zinc"}]},{"database":"DrugBank","id":"DB14487","properties":[{"key":"GenericName","value":"Zinc acetate"}]},{"database":"DrugBank","id":"DB14533","properties":[{"key":"GenericName","value":"Zinc chloride"}]},{"database":"DrugBank","id":"DB14548","properties":[{"key":"GenericName","value":"Zinc sulfate, unspecified form"}]},{"database":"DrugCentral","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"CarbonylDB","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P00441","properties":[{"key":"glycosylation","value":"2 N-Linked glycans (1 site)"}]},{"database":"GlyCosmos","id":"P00441","properties":[{"key":"glycosylation","value":"1 site, 2 glycans"}]},{"database":"GlyGen","id":"P00441","properties":[{"key":"glycosylation","value":"2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SOD1","properties":[{"key":"Description","value":"-"}]},{"database":"OGP","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"IPI00783680","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000270142","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51250","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P00441","properties":[{"key":"antibodies","value":"35 sequenced antibodies"}]},{"database":"Antibodypedia","id":"786","properties":[{"key":"antibodies","value":"1727 antibodies from 53 providers"}]},{"database":"DNASU","id":"6647","properties":[{"key":"Description","value":"-"}]},{"database":"YCharOS","id":"P00441","properties":[{"key":"antibodies","value":"Tested 12 antibodies from 6 manufacturers"}]},{"database":"Ensembl","id":"ENST00000270142.11","properties":[{"key":"ProteinId","value":"ENSP00000270142.7"},{"key":"GeneId","value":"ENSG00000142168.16"}]},{"database":"GeneID","id":"6647","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6647","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000270142.11","properties":[{"key":"ProteinId","value":"ENSP00000270142.7"},{"key":"RefSeqNucleotideId","value":"NM_000454.5"},{"key":"RefSeqProteinId","value":"NP_000445.1"}]},{"database":"AGR","id":"HGNC:11179","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA334","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6647","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6647","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SOD1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11179","properties":[{"key":"GeneName","value":"SOD1"}]},{"database":"HPA","id":"ENSG00000142168","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (liver)"}]},{"database":"MalaCards","id":"SOD1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"105400","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"147450","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"618598","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000142168","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"803","properties":[{"key":"Disease","value":"Amyotrophic lateral sclerosis"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000142168","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0441","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155551","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_056632_4_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACGKTHM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2015551at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P00441","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:HS06899-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"1.15.1.1","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-114608","properties":[{"key":"PathwayName","value":"Platelet degranulation"}]},{"database":"Reactome","id":"R-HSA-3299685","properties":[{"key":"PathwayName","value":"Detoxification of Reactive Oxygen Species"}]},{"database":"Reactome","id":"R-HSA-8950505","properties":[{"key":"PathwayName","value":"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"}]},{"database":"SignaLink","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000142168","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6647","properties":[{"key":"hits","value":"803 hits in 1146 CRISPR screens"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"CD-CODE","id":"F1AC7DF2","properties":[{"key":"EntryName","value":"Synthetic Condensate 000382"}]},{"database":"ChiTaRS","id":"SOD1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P00441","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"SOD1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6647","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P00441","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P00441","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"RNAct","id":"P00441","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000142168","properties":[{"key":"ExpressionPatterns","value":"Expressed in pons and 213 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P00441","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:1904115","properties":[{"key":"GoTerm","value":"C:axon cytoplasm"},{"key":"GoEvidenceType","value":"IEA:GOC"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11527942"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17077646"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17504823"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19741096"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24023695"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9726962"}]},{"database":"GO","id":"GO:0031410","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17077646"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16790527"}]},{"database":"GO","id":"GO:0032839","properties":[{"key":"GoTerm","value":"C:dendrite cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17324120"}]},{"database":"GO","id":"GO:0031045","properties":[{"key":"GoTerm","value":"C:dense core granule"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9453566"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005758","properties":[{"key":"GoTerm","value":"C:mitochondrial intermembrane space"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24026195"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17008312"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16790527"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19741096"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17324120"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1332049"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17504823"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22496122"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24023695"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9726962"}]},{"database":"GO","id":"GO:0005777","properties":[{"key":"GoTerm","value":"C:peroxisome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1332049"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17324120"}]},{"database":"GO","id":"GO:1902694","properties":[{"key":"GoTerm","value":"C:superoxide dismutase copper chaperone complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"30735496"}]},{"database":"GO","id":"GO:0005507","properties":[{"key":"GoTerm","value":"F:copper ion binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17008312"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17592131"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19022905"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19171884"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19369197"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19828437"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21257910"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23831581"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"26643113"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"31999698"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24567322"}]},{"database":"GO","id":"GO:0030346","properties":[{"key":"GoTerm","value":"F:protein phosphatase 2B binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17324120"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"9726962"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18219391"}]},{"database":"GO","id":"GO:0004784","properties":[{"key":"GoTerm","value":"F:superoxide dismutase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15544046"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17324120"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24140062"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17381088"}]},{"database":"GO","id":"GO:0008089","properties":[{"key":"GoTerm","value":"P:anterograde axonal transport"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"20510358"}]},{"database":"GO","id":"GO:0060088","properties":[{"key":"GoTerm","value":"P:auditory receptor cell stereocilium organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071318","properties":[{"key":"GoTerm","value":"P:cellular response to ATP"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071276","properties":[{"key":"GoTerm","value":"P:cellular response to cadmium ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035865","properties":[{"key":"GoTerm","value":"P:cellular response to potassium ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007566","properties":[{"key":"GoTerm","value":"P:embryo implantation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006749","properties":[{"key":"GoTerm","value":"P:glutathione metabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060047","properties":[{"key":"GoTerm","value":"P:heart contraction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9539776"}]},{"database":"GO","id":"GO:0050665","properties":[{"key":"GoTerm","value":"P:hydrogen peroxide biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15544046"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007626","properties":[{"key":"GoTerm","value":"P:locomotory behavior"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046716","properties":[{"key":"GoTerm","value":"P:muscle cell cellular homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0002262","properties":[{"key":"GoTerm","value":"P:myeloid cell homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050728","properties":[{"key":"GoTerm","value":"P:negative regulation of inflammatory response"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043524","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060052","properties":[{"key":"GoTerm","value":"P:neurofilament cytoskeleton organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001541","properties":[{"key":"GoTerm","value":"P:ovarian follicle development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032287","properties":[{"key":"GoTerm","value":"P:peripheral nervous system myelin maintenance"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001890","properties":[{"key":"GoTerm","value":"P:placenta development"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12485882"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IC:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16790527"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15544046"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1902177","properties":[{"key":"GoTerm","value":"P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12551919"}]},{"database":"GO","id":"GO:0050766","properties":[{"key":"GoTerm","value":"P:positive regulation of phagocytosis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032930","properties":[{"key":"GoTerm","value":"P:positive regulation of superoxide anion generation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18219391"}]},{"database":"GO","id":"GO:0072593","properties":[{"key":"GoTerm","value":"P:reactive oxygen species metabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24140062"}]},{"database":"GO","id":"GO:0008217","properties":[{"key":"GoTerm","value":"P:regulation of blood pressure"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043087","properties":[{"key":"GoTerm","value":"P:regulation of GTPase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18219391"}]},{"database":"GO","id":"GO:0051881","properties":[{"key":"GoTerm","value":"P:regulation of mitochondrial membrane potential"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16790527"}]},{"database":"GO","id":"GO:0040014","properties":[{"key":"GoTerm","value":"P:regulation of multicellular organism growth"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046620","properties":[{"key":"GoTerm","value":"P:regulation of organ growth"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16716898"}]},{"database":"GO","id":"GO:0033081","properties":[{"key":"GoTerm","value":"P:regulation of T cell differentiation in thymus"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16716898"}]},{"database":"GO","id":"GO:0060087","properties":[{"key":"GoTerm","value":"P:relaxation of vascular associated smooth muscle"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0019430","properties":[{"key":"GoTerm","value":"P:removal of superoxide radicals"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16254550"}]},{"database":"GO","id":"GO:0001975","properties":[{"key":"GoTerm","value":"P:response to amphetamine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097332","properties":[{"key":"GoTerm","value":"P:response to antipsychotic drug"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048678","properties":[{"key":"GoTerm","value":"P:response to axon injury"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0034465","properties":[{"key":"GoTerm","value":"P:response to carbon monoxide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046688","properties":[{"key":"GoTerm","value":"P:response to copper ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045471","properties":[{"key":"GoTerm","value":"P:response to ethanol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0009408","properties":[{"key":"GoTerm","value":"P:response to heat"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042542","properties":[{"key":"GoTerm","value":"P:response to hydrogen peroxide"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031667","properties":[{"key":"GoTerm","value":"P:response to nutrient levels"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000303","properties":[{"key":"GoTerm","value":"P:response to superoxide"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16790527"}]},{"database":"GO","id":"GO:0001895","properties":[{"key":"GoTerm","value":"P:retina homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008090","properties":[{"key":"GoTerm","value":"P:retrograde axonal transport"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"20510358"}]},{"database":"GO","id":"GO:0007605","properties":[{"key":"GoTerm","value":"P:sensory perception of sound"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007283","properties":[{"key":"GoTerm","value":"P:spermatogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006801","properties":[{"key":"GoTerm","value":"P:superoxide metabolic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12551919"}]},{"database":"GO","id":"GO:0048538","properties":[{"key":"GoTerm","value":"P:thymus development"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16716898"}]},{"database":"GO","id":"GO:0019226","properties":[{"key":"GoTerm","value":"P:transmission of nerve impulse"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd00305","properties":[{"key":"EntryName","value":"Cu-Zn_Superoxide_Dismutase"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP00652","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.60.40.200:FF:000001","properties":[{"key":"EntryName","value":"Superoxide dismutase [Cu-Zn]"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.200","properties":[{"key":"EntryName","value":"Superoxide dismutase, copper/zinc binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036423","properties":[{"key":"EntryName","value":"SOD-like_Cu/Zn_dom_sf"}]},{"database":"InterPro","id":"IPR024134","properties":[{"key":"EntryName","value":"SOD_Cu/Zn/SOD-chaperone"}]},{"database":"InterPro","id":"IPR018152","properties":[{"key":"EntryName","value":"SOD_Cu/Zn_BS"}]},{"database":"InterPro","id":"IPR001424","properties":[{"key":"EntryName","value":"SOD_Cu_Zn_dom"}]},{"database":"PANTHER","id":"PTHR10003","properties":[{"key":"EntryName","value":"SUPEROXIDE DISMUTASE CU-ZN -RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00080","properties":[{"key":"EntryName","value":"Sod_Cu"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00068","properties":[{"key":"EntryName","value":"CUZNDISMTASE"}]},{"database":"SUPFAM","id":"SSF49329","properties":[{"key":"EntryName","value":"Cu,Zn superoxide dismutase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00087","properties":[{"key":"EntryName","value":"SOD_CU_ZN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00332","properties":[{"key":"EntryName","value":"SOD_CU_ZN_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ","length":154,"molWeight":15936,"crc64":"25CA38DA8D564483","md5":"A25927AAA0D8BA452E707AA9B1B9A977"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":2,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":81,"SUBCELLULAR LOCATION":1,"PTM":4,"DISEASE":2,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":2,"WEB RESOURCE":2},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Binding site":8,"Modified residue":12,"Lipidation":1,"Disulfide bond":1,"Cross-link":1,"Natural variant":81,"Mutagenesis":14,"Sequence conflict":2,"Beta strand":22,"Helix":4,"Turn":2},"uniParcId":"UPI0000000C20"}}