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May play a role in tumor development (PubMed:10564580)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q78TU8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20543869"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21969592"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28604741"}],"value":"Interacts with ACTB (PubMed:21969592, PubMed:28604741). Interacts with COMMD1; this interaction stabilizes COMMD1 in the nucleus (PubMed:28604741). Interacts with MAP1A (PubMed:20543869). Interacts with PRDX1 (PubMed:21969592). Interacts with F-actin (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O95990-3","intActId":"EBI-10192902"},"interactantTwo":{"uniProtKBAccession":"Q96JN2-2","geneName":"CCDC136","intActId":"EBI-10171416"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-3","intActId":"EBI-10192902"},"interactantTwo":{"uniProtKBAccession":"A1L4K1","geneName":"FSD2","intActId":"EBI-5661036"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-3","intActId":"EBI-10192902"},"interactantTwo":{"uniProtKBAccession":"Q6A162","geneName":"KRT40","intActId":"EBI-10171697"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-3","intActId":"EBI-10192902"},"interactantTwo":{"uniProtKBAccession":"Q9BRK4","geneName":"LZTS2","intActId":"EBI-741037"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-3","intActId":"EBI-10192902"},"interactantTwo":{"uniProtKBAccession":"Q9UJV3-2","geneName":"MID2","intActId":"EBI-10172526"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-3","intActId":"EBI-10192902"},"interactantTwo":{"uniProtKBAccession":"Q8ND90","geneName":"PNMA1","intActId":"EBI-302345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-3","intActId":"EBI-10192902"},"interactantTwo":{"uniProtKBAccession":"Q6NUQ1","geneName":"RINT1","intActId":"EBI-726876"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-3","intActId":"EBI-10192902"},"interactantTwo":{"uniProtKBAccession":"O94972","geneName":"TRIM37","intActId":"EBI-741602"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-3","intActId":"EBI-10192902"},"interactantTwo":{"uniProtKBAccession":"Q8N6Y0","geneName":"USHBP1","intActId":"EBI-739895"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-4","intActId":"EBI-11977223"},"interactantTwo":{"uniProtKBAccession":"Q86Z20","geneName":"CCDC125","intActId":"EBI-11977221"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-4","intActId":"EBI-11977223"},"interactantTwo":{"uniProtKBAccession":"Q2TAC2-2","geneName":"CCDC57","intActId":"EBI-10961624"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-4","intActId":"EBI-11977223"},"interactantTwo":{"uniProtKBAccession":"P62508-3","geneName":"ESRRG","intActId":"EBI-12001340"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-4","intActId":"EBI-11977223"},"interactantTwo":{"uniProtKBAccession":"A6NEM1","geneName":"GOLGA6L9","intActId":"EBI-5916454"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-4","intActId":"EBI-11977223"},"interactantTwo":{"uniProtKBAccession":"O75031","geneName":"HSF2BP","intActId":"EBI-7116203"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-4","intActId":"EBI-11977223"},"interactantTwo":{"uniProtKBAccession":"Q7Z3Y8","geneName":"KRT27","intActId":"EBI-3044087"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-4","intActId":"EBI-11977223"},"interactantTwo":{"uniProtKBAccession":"Q5JR59-3","geneName":"MTUS2","intActId":"EBI-11522433"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-4","intActId":"EBI-11977223"},"interactantTwo":{"uniProtKBAccession":"Q8NI38","geneName":"NFKBID","intActId":"EBI-10271199"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O95990-4","intActId":"EBI-11977223"},"interactantTwo":{"uniProtKBAccession":"Q12933","geneName":"TRAF2","intActId":"EBI-355744"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20543869"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28604741"}],"value":"Colocalizes with F-actin and COMMD1 in the nucleus (PubMed:28604741). Colocalizes with MAP1A along actin stress fibers and membrane ruffles (PubMed:20543869)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10564580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11256614"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20543869"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28604741"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20543869"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28604741"}],"value":"Cytoplasm, cytoskeleton, stress fiber","id":"SL-0501"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20543869"}],"value":"Cell junction, focal adhesion","id":"SL-0118"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20543869"}],"value":"Cell projection, ruffle membrane","id":"SL-0301"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q78TU8"}],"value":"Synapse","id":"SL-0258"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["O95990-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["O95990-2"],"sequenceIds":["VSP_009232"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["O95990-3"],"sequenceIds":["VSP_054803"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["O95990-4"],"sequenceIds":["VSP_054804"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10564580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20543869"}],"value":"Widely expressed (PubMed:10564580). Expressed in neurons (PubMed:20543869). Expressed in malignant glial tumors (PubMed:20543869). Expression is reduced or absent in a number of cancer cell lines (PubMed:10564580)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"May be due to an intron retention"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the FAM107 family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/42728/FAM107A","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"Actin-associated protein FAM107A","featureId":"PRO_0000080014"},{"type":"Region","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Motif","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28604741"}]},{"type":"Compositional bias","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_054803","alternativeSequence":{"originalSequence":"M","alternativeSequences":["MAQRLGEWARGPSDATGLYRAVLLRSAAM"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_054804","alternativeSequence":{"originalSequence":"M","alternativeSequences":["MGAAQGKKKTYSPQARFHSENEKQRRNGSAAM"]}},{"type":"Alternative sequence","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_009232","alternativeSequence":{"originalSequence":"LEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL","alternativeSequences":["VGDGHPAGTTHPPGLSSREELCCGHS"]}},{"type":"Natural variant","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"in ovarian cancer and renal cell carcinoma cell lines","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10564580"}],"featureId":"VAR_017238","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"in renal cell carcinoma cell line","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10564580"}],"featureId":"VAR_017239","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"in dbSNP:rs1043942","featureCrossReferences":[{"database":"dbSNP","id":"rs1043942"}],"featureId":"VAR_049016","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"in dbSNP:rs11539086","featureCrossReferences":[{"database":"dbSNP","id":"rs11539086"}],"featureId":"VAR_049017","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Increases nuclear and diffused cytoplasm localization, decreases interaction with MAP1A, alters actin cytoskeleton organization and decreases focal adhesion (FA) disassembly and cell migration.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20543869"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Increases diffused cytoplasm localization, loss of interaction with ACTB and colocalization with nuclear F-actin, decreases COMMD1 protein stability and ubiquitination of NF-kappa-B subunit RELA and decreases focal adhesion (FA) disassembly and cell migration; 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