ID   ANGL1_HUMAN             Reviewed;         491 AA.
AC   O95841; Q5T5Z5;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 162.
DE   RecName: Full=Angiopoietin-related protein 1;
DE   AltName: Full=Angiopoietin-3;
DE            Short=ANG-3;
DE   AltName: Full=Angiopoietin-like protein 1;
DE   Flags: Precursor;
GN   Name=ANGPTL1; Synonyms=ANG3, ANGPT3, ARP1;
GN   ORFNames=PSEC0154, UNQ162/PRO188;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Heart;
RX   PubMed=10025962; DOI=10.1016/s0014-5793(99)00008-3;
RA   Kim I., Kwak H.J., Ahn J.E., So J.-N., Liu M., Koh K.N., Koh G.Y.;
RT   "Molecular cloning and characterization of a novel angiopoietin family
RT   protein, angiopoietin-3.";
RL   FEBS Lett. 443:353-356(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA   Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA   Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA   Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA   Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA   Isogai T.;
RT   "Signal sequence and keyword trap in silico for selection of full-length
RT   human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT   libraries.";
RL   DNA Res. 12:117-126(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10025962}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in adrenal gland, placenta,
CC       thyroid gland, heart, skeletal muscle and small intestine. Weakly
CC       expressed in testis, ovary, colon, pancreas, kidney and stomach.
CC       {ECO:0000269|PubMed:10025962}.
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DR   EMBL; AF107253; AAD19608.1; -; mRNA.
DR   EMBL; AY358278; AAQ88645.1; -; mRNA.
DR   EMBL; AB056476; BAB40691.1; -; mRNA.
DR   EMBL; AL355520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC050640; AAH50640.1; -; mRNA.
DR   CCDS; CCDS1327.1; -.
DR   RefSeq; NP_004664.1; NM_004673.3.
DR   RefSeq; XP_005245634.1; XM_005245577.2.
DR   AlphaFoldDB; O95841; -.
DR   SMR; O95841; -.
DR   BioGRID; 114526; 1.
DR   STRING; 9606.ENSP00000234816; -.
DR   GlyCosmos; O95841; 2 sites, No reported glycans.
DR   GlyGen; O95841; 2 sites.
DR   iPTMnet; O95841; -.
DR   PhosphoSitePlus; O95841; -.
DR   BioMuta; ANGPTL1; -.
DR   EPD; O95841; -.
DR   jPOST; O95841; -.
DR   MassIVE; O95841; -.
DR   PaxDb; 9606-ENSP00000234816; -.
DR   PeptideAtlas; O95841; -.
DR   ProteomicsDB; 51085; -.
DR   Antibodypedia; 1217; 457 antibodies from 30 providers.
DR   DNASU; 9068; -.
DR   Ensembl; ENST00000234816.7; ENSP00000234816.2; ENSG00000116194.13.
DR   Ensembl; ENST00000367629.1; ENSP00000356601.1; ENSG00000116194.13.
DR   GeneID; 9068; -.
DR   KEGG; hsa:9068; -.
DR   MANE-Select; ENST00000234816.7; ENSP00000234816.2; NM_004673.4; NP_004664.1.
DR   UCSC; uc001gma.4; human.
DR   AGR; HGNC:489; -.
DR   CTD; 9068; -.
DR   DisGeNET; 9068; -.
DR   GeneCards; ANGPTL1; -.
DR   HGNC; HGNC:489; ANGPTL1.
DR   HPA; ENSG00000116194; Tissue enhanced (placenta).
DR   MIM; 603874; gene.
DR   neXtProt; NX_O95841; -.
DR   OpenTargets; ENSG00000116194; -.
DR   PharmGKB; PA24794; -.
DR   VEuPathDB; HostDB:ENSG00000116194; -.
DR   eggNOG; KOG2579; Eukaryota.
DR   GeneTree; ENSGT00940000155091; -.
DR   HOGENOM; CLU_038628_0_0_1; -.
DR   InParanoid; O95841; -.
DR   OMA; CQHAKDA; -.
DR   OrthoDB; 3134470at2759; -.
DR   PhylomeDB; O95841; -.
DR   TreeFam; TF336658; -.
DR   PathwayCommons; O95841; -.
DR   SignaLink; O95841; -.
DR   SIGNOR; O95841; -.
DR   BioGRID-ORCS; 9068; 11 hits in 1154 CRISPR screens.
DR   ChiTaRS; ANGPTL1; human.
DR   GeneWiki; ANGPTL1; -.
DR   GenomeRNAi; 9068; -.
DR   Pharos; O95841; Tbio.
DR   PRO; PR:O95841; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; O95841; Protein.
DR   Bgee; ENSG00000116194; Expressed in left uterine tube and 158 other cell types or tissues.
DR   ExpressionAtlas; O95841; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   NCBIfam; NF040941; GGGWT_bact; 1.
DR   PANTHER; PTHR19143:SF25; ANGIOPOIETIN-RELATED PROTEIN 1; 1.
DR   PANTHER; PTHR19143; FIBRINOGEN/TENASCIN/ANGIOPOEITIN; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR   Genevisible; O95841; HS.
PE   2: Evidence at transcript level;
KW   Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..491
FT                   /note="Angiopoietin-related protein 1"
FT                   /id="PRO_0000009118"
FT   DOMAIN          271..491
FT                   /note="Fibrinogen C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   COILED          80..168
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        280..309
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   DISULFID        432..445
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
SQ   SEQUENCE   491 AA;  56720 MW;  3C4DB8DEF6CF7E99 CRC64;
     MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA YTFLVPEQRI
     TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID VLQLVVDVDG NIVNEVKLLR
     KESRNMNSRV TQLYMQLLHE IIRKRDNSLE LSQLENKILN VTTEMLKMAT RYRELEVKYA
     SLTDLVNNQS VMITLLEEQC LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ
     RDPGYPRDLM PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN
     SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW LGLENIYMLS
     NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG TYQGNAGDSM MWHNGKQFTT
     LDRDKDMYAG NCAHFHKGGW WYNACAHSNL NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL
     RAVQMMIKPI D
//