{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O94903","secondaryAccessions":["Q6FI94"],"uniProtkbId":"PLPHP_HUMAN","entryAudit":{"firstPublicDate":"2001-01-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1999-05-01","entryVersion":199,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03225"}],"value":"Pyridoxal phosphate homeostasis protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03225"}],"value":"PLP homeostasis protein"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03225"}],"value":"Proline synthase co-transcribed bacterial homolog protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:9457"}],"value":"Pyridoxal phosphate-binding protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03225"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:9457"}],"value":"PLPBP"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03225"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:9457"}],"value":"PROSC"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27912044"}],"value":"Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6"}],"commentType":"FUNCTION"},{"texts":[{"value":"Ubiquitous"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Epilepsy, early-onset, 1, vitamin B6-dependent","diseaseAccession":"DI-04934","acronym":"EPEO1","description":"An autosomal recessive neurologic disorder characterized by seizures responsive to treatment with activated vitamin B6 and/or pyridoxine. Most patients show delayed psychomotor development, intellectual disability and learning disability. Seizures onset is in the first days or months of life.","diseaseCrossReference":{"database":"MIM","id":"617290"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27912044"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03225"}],"value":"Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Pyridoxal phosphate homeostasis protein","featureId":"PRO_0000163210"},{"type":"Region","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03225"}]},{"type":"Modified residue","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z2Y8"}]},{"type":"Modified residue","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"N6-succinyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z2Y8"}]},{"type":"Modified residue","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Natural variant","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"in dbSNP:rs35423325","featureCrossReferences":[{"database":"dbSNP","id":"rs35423325"}],"featureId":"VAR_052476","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"in EPEO1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27912044"}],"featureId":"VAR_078004","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"in EPEO1; decreased expression at the mRNA level; undetectable at the protein level in patient's fibroblasts","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27912044"}],"featureId":"VAR_078005","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"in EPEO1; dbSNP:rs755946598","featureCrossReferences":[{"database":"dbSNP","id":"rs755946598"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27912044"}],"featureId":"VAR_078006","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in EPEO1; decreased expression at the mRNA level; undetectable at the protein level in patient's fibroblasts; dbSNP:rs752753379","featureCrossReferences":[{"database":"dbSNP","id":"rs752753379"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27912044"}],"featureId":"VAR_078007","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in EPEO1; dbSNP:rs760609867","featureCrossReferences":[{"database":"dbSNP","id":"rs760609867"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27912044"}],"featureId":"VAR_078008","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}}],"keywords":[{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0887","category":"Disease","name":"Epilepsy"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10496079","citationType":"journal article","authors":["Ikegawa S.","Isomura M.","Koshizuka Y.","Nakamura Y."],"citationCrossReferences":[{"database":"PubMed","id":"10496079"},{"database":"DOI","id":"10.1007/s100380050172"}],"title":"Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes.","publicationDate":"1999","journal":"J. Hum. Genet.","firstPage":"337","lastPage":"342","volume":"44"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"11230166","citationType":"journal article","authors":["Wiemann S.","Weil B.","Wellenreuther R.","Gassenhuber J.","Glassl S.","Ansorge W.","Boecher M.","Bloecker H.","Bauersachs S.","Blum H.","Lauber J.","Duesterhoeft A.","Beyer A.","Koehrer K.","Strack N.","Mewes H.-W.","Ottenwaelder B.","Obermaier B.","Tampe J.","Heubner D.","Wambutt R.","Korn B.","Klein M.","Poustka A."],"citationCrossReferences":[{"database":"PubMed","id":"11230166"},{"database":"DOI","id":"10.1101/gr.gr1547r"}],"title":"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.","publicationDate":"2001","journal":"Genome Res.","firstPage":"422","lastPage":"435","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-D49P6QQO8F5LU","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":6,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-244","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226 AND SER-244","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"27912044","citationType":"journal article","authors":["Darin N.","Reid E.","Prunetti L.","Samuelsson L.","Husain R.A.","Wilson M.","El Yacoubi B.","Footitt E.","Chong W.K.","Wilson L.C.","Prunty H.","Pope S.","Heales S.","Lascelles K.","Champion M.","Wassmer E.","Veggiotti P.","de Crecy-Lagard V.","Mills P.B.","Clayton P.T."],"citationCrossReferences":[{"database":"PubMed","id":"27912044"},{"database":"DOI","id":"10.1016/j.ajhg.2016.10.011"}],"title":"Mutations in PROSC disrupt cellular pyridoxal phosphate homeostasis and cause vitamin-B6-dependent epilepsy.","publicationDate":"2016","journal":"Am. J. Hum. Genet.","firstPage":"1325","lastPage":"1337","volume":"99"},"referencePositions":["INVOLVEMENT IN EPEO1","FUNCTION","VARIANTS EPEO1 71-GLN--HIS-275 DEL; 78-SER--HIS-275 DEL; LEU-87; PRO-175 AND GLN-241","CHARACTERIZATION OF VARIANTS EPEO1 78-SER--HIS-275 DEL AND PRO-175"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB018566","properties":[{"key":"ProteinId","value":"BAA36842.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL136616","properties":[{"key":"ProteinId","value":"CAB66551.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR533532","properties":[{"key":"ProteinId","value":"CAG38563.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC012334","properties":[{"key":"ProteinId","value":"AAH12334.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS6096.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_009129.1","properties":[{"key":"NucleotideSequenceId","value":"NM_007198.4"}]},{"database":"AlphaFoldDB","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"116381","properties":[{"key":"Interactions","value":"132"}]},{"database":"FunCoup","id":"O94903","properties":[{"key":"Number of interactors","value":"2143"}]},{"database":"IntAct","id":"O94903","properties":[{"key":"Interactions","value":"54"}]},{"database":"MINT","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-PLPBP","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000333551","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5725171","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB00172","properties":[{"key":"GenericName","value":"Proline"}]},{"database":"DrugBank","id":"DB00114","properties":[{"key":"GenericName","value":"Pyridoxal phosphate"}]},{"database":"GlyGen","id":"O94903","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PLPBP","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000333551","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"50537","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4465","properties":[{"key":"antibodies","value":"293 antibodies from 24 providers"}]},{"database":"DNASU","id":"11212","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000328195.8","properties":[{"key":"ProteinId","value":"ENSP00000333551.3"},{"key":"GeneId","value":"ENSG00000147471.13"}]},{"database":"GeneID","id":"11212","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:11212","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000328195.8","properties":[{"key":"ProteinId","value":"ENSP00000333551.3"},{"key":"RefSeqNucleotideId","value":"NM_007198.4"},{"key":"RefSeqProteinId","value":"NP_009129.1"}]},{"database":"UCSC","id":"uc003xkh.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:9457","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA33810","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"11212","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"11212","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PLPBP","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"PLPBP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9457","properties":[{"key":"GeneName","value":"PLPBP"}]},{"database":"HPA","id":"ENSG00000147471","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"PLPBP","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"604436","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"617290","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000147471","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"3006","properties":[{"key":"Disease","value":"Pyridoxine-dependent-developmental and epileptic encephalopathy"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000147471","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3157","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000004928","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_059988_2_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PLEWHMI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10264196at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O94903","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"O94903","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000147471","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"11212","properties":[{"key":"hits","value":"15 hits in 1161 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"PROSC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"PROSC","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"11212","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O94903","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:O94903","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"O94903","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000147471","properties":[{"key":"ExpressionPatterns","value":"Expressed in cardia of stomach and 219 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O94903","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10496079"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"HTP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0006056","source":"PubMed","id":"34800366"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042816","properties":[{"key":"GoTerm","value":"P:vitamin B6 metabolic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd06822","properties":[{"key":"EntryName","value":"PLPDE_III_YBL036c_euk"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.10:FF:000007","properties":[{"key":"EntryName","value":"Pyridoxal phosphate homeostasis protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.10","properties":[{"key":"EntryName","value":"Alanine racemase"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_02087","properties":[{"key":"EntryName","value":"PLP_homeostasis"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001608","properties":[{"key":"EntryName","value":"Ala_racemase_N"}]},{"database":"InterPro","id":"IPR029066","properties":[{"key":"EntryName","value":"PLP-binding_barrel"}]},{"database":"InterPro","id":"IPR011078","properties":[{"key":"EntryName","value":"PyrdxlP_homeostasis"}]},{"database":"NCBIfam","id":"TIGR00044","properties":[{"key":"EntryName","value":"YggS family pyridoxal phosphate-dependent enzyme"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10146","properties":[{"key":"EntryName","value":"PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10146:SF14","properties":[{"key":"EntryName","value":"PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01168","properties":[{"key":"EntryName","value":"Ala_racemase_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF004848","properties":[{"key":"EntryName","value":"YBL036c_PLPDEIII"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51419","properties":[{"key":"EntryName","value":"PLP-binding barrel"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01211","properties":[{"key":"EntryName","value":"UPF0001"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHAVEVGSTNVRIGSTIFGERDYSKKPTPDKCAADVKAPLEVAQEH","length":275,"molWeight":30344,"crc64":"A81049432B1A8732","md5":"7F6BCB7A967B4A0184E36A30032A8C1C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"TISSUE SPECIFICITY":1,"DISEASE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Modified residue":6,"Natural variant":6},"uniParcId":"UPI0000131F89"}}