{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O94763","secondaryAccessions":["A8K805","H7BY42","Q8TC23","Q9UNU3"],"uniProtkbId":"RMP_HUMAN","entryAudit":{"firstPublicDate":"2002-03-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-06-16","entryVersion":196,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Unconventional prefoldin RPB5 interactor 1"}},"alternativeNames":[{"fullName":{"value":"Protein NNX3"}},{"fullName":{"value":"Protein phosphatase 1 regulatory subunit 19"}},{"fullName":{"value":"RNA polymerase II subunit 5-mediating protein"},"shortNames":[{"value":"RPB5-mediating protein"}]}]},"genes":[{"geneName":{"value":"URI1"},"synonyms":[{"value":"C19orf2"},{"value":"NNX3"},{"value":"PPP1R19"},{"value":"RMP"},{"value":"URI"}]}],"comments":[{"texts":[{"value":"Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein"}],"commentType":"FUNCTION"},{"texts":[{"value":"Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12737519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14615539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15367675"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21397856"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21730289"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28561026"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31738558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9819440"}],"value":"Homodimer. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (PubMed:31738558). Interacts with POLR2E/RPB5, RUVBL2 and RUVBL1 (PubMed:14615539, PubMed:9819440). Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occur in a growth-dependent manner in the mitochondrion (PubMed:14615539). Interacts with UXT (PubMed:21730289). Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner (PubMed:21397856). Interacts (via the middle C-terminal region) with GTF2F1 and GTF2F2 (PubMed:12737519). Interacts with DMAP1 (PubMed:15367675). Interacts with TSC1 and TSC2 (PubMed:28561026). Interacts with PRPF8 and EFTUD2 in a ZNHIT2-dependent manner (PubMed:28561026)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"P35269","geneName":"GTF2F1","intActId":"EBI-457886"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"P13984","geneName":"GTF2F2","intActId":"EBI-1030560"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"O15294","geneName":"OGT","intActId":"EBI-539828"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"Q9UHV9","geneName":"PFDN2","intActId":"EBI-359873"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"P19388","geneName":"POLR2E","intActId":"EBI-395189"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"P36873","geneName":"PPP1CC","intActId":"EBI-356283"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"Q15185","geneName":"PTGES3","intActId":"EBI-1049387"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"Q9H6T3","geneName":"RPAP3","intActId":"EBI-356928"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"P30561","geneName":"Ahr","intActId":"EBI-78863"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O94763","intActId":"EBI-357067"},"interactantTwo":{"uniProtKBAccession":"P19785","geneName":"Esr1","intActId":"EBI-346765"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O94763-1","intActId":"EBI-12590720"},"interactantTwo":{"uniProtKBAccession":"O15294","geneName":"OGT","intActId":"EBI-539828"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94763-1","intActId":"EBI-12590720"},"interactantTwo":{"uniProtKBAccession":"P36873","geneName":"PPP1CC","intActId":"EBI-356283"},"numberOfExperiments":8,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}},{"location":{"value":"Mitochondrion","id":"SL-0173"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell projection, dendrite","id":"SL-0283"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["O94763-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["O94763-2"],"sequenceIds":["VSP_032773"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["O94763-3"],"sequenceIds":["VSP_042259"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["O94763-4"],"sequenceIds":["VSP_044769","VSP_044770"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21397856"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21730289"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9819440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9878255"}],"value":"Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17936702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21397856"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21730289"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9878255"}],"value":"Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the RNA polymerase II subunit 5-mediating protein family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH26184.2","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":535,"modifier":"EXACT"}},"description":"Unconventional prefoldin RPB5 interactor 1","featureId":"PRO_0000097365"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"Phosphoserine; 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