{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O94708","secondaryAccessions":["P78923","Q1L839"],"uniProtkbId":"YC58_SCHPO","entryAudit":{"firstPublicDate":"2008-11-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1999-05-01","entryVersion":98,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","commonName":"Fission yeast","taxonId":284812,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Taphrinomycotina","Schizosaccharomycetes","Schizosaccharomycetales","Schizosaccharomycetaceae","Schizosaccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein C1259.08"}}},"genes":[{"orfNames":[{"value":"SPCC1259.08"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16823372"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous termination","sequence":"BAA13935.1","note":"Truncated C-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAA13935.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Uncharacterized protein C1259.08","featureId":"PRO_0000353135"},{"type":"Region","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18257517"}]},{"type":"Modified residue","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18257517"}]},{"type":"Modified residue","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18257517"}]},{"type":"Sequence conflict","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"in Ref. 2; BAA13935","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11859360","citationType":"journal article","authors":["Wood V.","Gwilliam R.","Rajandream M.A.","Lyne M.H.","Lyne R.","Stewart A.","Sgouros J.G.","Peat N.","Hayles J.","Baker S.G.","Basham D.","Bowman S.","Brooks K.","Brown D.","Brown S.","Chillingworth T.","Churcher C.M.","Collins M.","Connor R.","Cronin A.","Davis P.","Feltwell T.","Fraser A.","Gentles S.","Goble A.","Hamlin N.","Harris D.E.","Hidalgo J.","Hodgson G.","Holroyd S.","Hornsby T.","Howarth S.","Huckle E.J.","Hunt S.","Jagels K.","James K.D.","Jones L.","Jones M.","Leather S.","McDonald S.","McLean J.","Mooney P.","Moule S.","Mungall K.L.","Murphy L.D.","Niblett D.","Odell C.","Oliver K.","O'Neil S.","Pearson D.","Quail M.A.","Rabbinowitsch E.","Rutherford K.M.","Rutter S.","Saunders D.","Seeger K.","Sharp S.","Skelton J.","Simmonds M.N.","Squares R.","Squares S.","Stevens K.","Taylor K.","Taylor R.G.","Tivey A.","Walsh S.V.","Warren T.","Whitehead S.","Woodward J.R.","Volckaert G.","Aert R.","Robben J.","Grymonprez B.","Weltjens I.","Vanstreels E.","Rieger M.","Schaefer M.","Mueller-Auer S.","Gabel C.","Fuchs M.","Duesterhoeft A.","Fritzc C.","Holzer E.","Moestl D.","Hilbert H.","Borzym K.","Langer I.","Beck A.","Lehrach H.","Reinhardt R.","Pohl T.M.","Eger P.","Zimmermann W.","Wedler H.","Wambutt R.","Purnelle B.","Goffeau A.","Cadieu E.","Dreano S.","Gloux S.","Lelaure V.","Mottier S.","Galibert F.","Aves S.J.","Xiang Z.","Hunt C.","Moore K.","Hurst S.M.","Lucas M.","Rochet M.","Gaillardin C.","Tallada V.A.","Garzon A.","Thode G.","Daga R.R.","Cruzado L.","Jimenez J.","Sanchez M.","del Rey F.","Benito J.","Dominguez A.","Revuelta J.L.","Moreno S.","Armstrong J.","Forsburg S.L.","Cerutti L.","Lowe T.","McCombie W.R.","Paulsen I.","Potashkin J.","Shpakovski G.V.","Ussery D.","Barrell B.G.","Nurse P."],"citationCrossReferences":[{"database":"PubMed","id":"11859360"},{"database":"DOI","id":"10.1038/nature724"}],"title":"The genome sequence of Schizosaccharomyces pombe.","publicationDate":"2002","journal":"Nature","firstPage":"871","lastPage":"880","volume":"415"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"972 / ATCC 24843","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9501991","citationType":"journal article","authors":["Yoshioka S.","Kato K.","Nakai K.","Okayama H.","Nojima H."],"citationCrossReferences":[{"database":"PubMed","id":"9501991"},{"database":"DOI","id":"10.1093/dnares/4.6.363"}],"title":"Identification of open reading frames in Schizosaccharomyces pombe cDNAs.","publicationDate":"1997","journal":"DNA Res.","firstPage":"363","lastPage":"369","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-157"],"referenceComments":[{"value":"PR745","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16823372","citationType":"journal article","authors":["Matsuyama A.","Arai R.","Yashiroda Y.","Shirai A.","Kamata A.","Sekido S.","Kobayashi Y.","Hashimoto A.","Hamamoto M.","Hiraoka Y.","Horinouchi S.","Yoshida M."],"citationCrossReferences":[{"database":"PubMed","id":"16823372"},{"database":"DOI","id":"10.1038/nbt1222"}],"title":"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"841","lastPage":"847","volume":"24"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":4,"citation":{"id":"18257517","citationType":"journal article","authors":["Wilson-Grady J.T.","Villen J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18257517"},{"database":"DOI","id":"10.1021/pr7006335"}],"title":"Phosphoproteome analysis of fission yeast.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1088","lastPage":"1097","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-121 AND SER-379","IDENTIFICATION BY MASS SPECTROMETRY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CU329672","properties":[{"key":"ProteinId","value":"CAA22546.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"D89274","properties":[{"key":"ProteinId","value":"BAA13935.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"T40897","properties":[{"key":"EntryName","value":"T40897"}]},{"database":"PIR","id":"T43204","properties":[{"key":"EntryName","value":"T43204"}]},{"database":"RefSeq","id":"NP_588064.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001023056.3"}]},{"database":"AlphaFoldDB","id":"O94708","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"275664","properties":[{"key":"Interactions","value":"22"}]},{"database":"STRING","id":"284812.O94708","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"O94708","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"284812-O94708","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"spo:2539092","properties":[{"key":"Description","value":"-"}]},{"database":"PomBase","id":"SPCC1259.08","properties":[{"key":"GeneName","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:SPCC1259.08","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S9SC","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_716019_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O94708","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LNREQQY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PRO","id":"PR:O94708","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002485","properties":[{"key":"Component","value":"Chromosome III"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"HDA:PomBase"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"16823372"}]},{"database":"InterPro","id":"IPR018853","properties":[{"key":"EntryName","value":"DUF2457"}]},{"database":"Pfam","id":"PF10446","properties":[{"key":"EntryName","value":"DUF2457"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTGLLSILLHYKGNGDLATTDIPSHEKIPSAKRTAVQFCIGPTHEQSPRMSTVSQGRVTFAVLPTKPKDEVTSMKANGSRQSSCIVSNARKRQSVHCLSRSPIPSTRLKENDSRLCSPLASPTGGLKRPAKVSFALANTPSRKGNLVPQSPRRTIATTCKGVLEDVLKKDNELKFNDSDEEDEVDDEEIESFNSFSRKMQTISNSRYRGSPKPNIEKQSCSSESDRVSQISDDEEDEEGSADEEDEEDSDVELSESSLSDDEDSPLRCPSTPVQTAAAPNESQIPDDTDFVPGTFDEDQPACLAFACSLTHANSKRSIMLPQDIDPTFPDSEPEDDGHASSTVGSLSKEEARFKAKAKWNYKSSFSAHVSSEVLRNSKSPPLDIARKAVGAHRV","length":394,"molWeight":43005,"crc64":"537B5BAC1061DFA4","md5":"D4D8FC8607862FC04CA6B7FD341C4D7B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Region":3,"Compositional bias":6,"Modified residue":3,"Sequence conflict":1},"uniParcId":"UPI000006C837"}}