{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O82872","uniProtkbId":"DTA_ARTSP","entryAudit":{"firstPublicDate":"2011-02-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-11-01","entryVersion":61,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Arthrobacter sp","taxonId":1667,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Micrococcales","Micrococcaceae","Arthrobacter"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9642221"}],"value":"D-threonine aldolase"},"ecNumbers":[{"value":"4.1.2.42"}]}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}],"value":"Catalyzes the reversible cleavage of D-threonine or D-allothreonine into glycine and acetaldehyde. Can also cleave D-beta-phenylserine, D-beta-hydroxy-alpha-aminovaleric acid, D-beta-3,4-dihydroxyphenylserine and D-beta-3,4-methylenedioxyphenylserine into glycine and the corresponding aldehyde compounds. Inactive towards D-serine, beta-hydroxyaspartate and O-phospho-DL-threonine"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-threonine = acetaldehyde + glycine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15257"},{"database":"ChEBI","id":"CHEBI:15343"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:57757"}],"ecNumber":"4.1.2.42","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-allo-threonine = acetaldehyde + glycine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20073"},{"database":"ChEBI","id":"CHEBI:15343"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:58645"}],"ecNumber":"4.1.2.42","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}],"value":"Binds 1 pyridoxal phosphate per subunit."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}},{"name":"Co(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:48828"}},{"name":"Ni(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:49786"}},{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9642221"}],"value":"Binds 1 Mn(2+) ion per subunit. Can also use Co(2+), Ni(2+) and Mg(2+)."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9346293"}],"value":"Inhibited by the carbonyl reagents hydroxylamine, phenylhydrazine and semicarbazide. Inhibited by the chelating agent EDTA. Inhibited by the sulfhydryl reagent p-chloromercuribenzoic acid, and by sodium cyanide. Inhibited by iodoacetate, Ag(2)SO(4), HgCl(2) and CdCl(2). 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