{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O81323","secondaryAccessions":["A0MF43","B7XG73","Q1PED1"],"uniProtkbId":"LBD30_ARATH","entryAudit":{"firstPublicDate":"2003-01-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-11-01","entryVersion":126,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"LOB domain-containing protein 30"}},"alternativeNames":[{"fullName":{"value":"ASYMMETRIC LEAVES 2-like protein 19"},"shortNames":[{"value":"AS2-like protein 19"}]}]},"genes":[{"geneName":{"value":"LBD30"},"synonyms":[{"value":"ASL19"}],"orderedLocusNames":[{"value":"At4g00220"}],"orfNames":[{"value":"F6N15.4"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19088331"}],"value":"Involved in the positive regulation of tracheary element (TE) differentiation. Involved in a positive feedback loop that maintains or promotes NAC030/VND7 expression that regulates TE differentiation-related genes"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O81323","intActId":"EBI-15201724"},"interactantTwo":{"uniProtKBAccession":"Q9SHE9","geneName":"LBD4","intActId":"EBI-4445715"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O81323","intActId":"EBI-15201724"},"interactantTwo":{"uniProtKBAccession":"Q93Z00","geneName":"TCP14","intActId":"EBI-4424563"},"numberOfExperiments":3,"organismDiffer":false}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12068116"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19088331"}],"value":"Expressed in roots, stems, leaves and flowers (PubMed:12068116). Expressed in vascular tissues of hypocotyls, leaves, roots, developing floral organs and siliques (PubMed:19088331)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19088331"}],"value":"Plants over-expressing LBD30 have a dwarf and bushy phenotype, with short petioles, curled downward leaves, ectopic shoots from the adaxial side of cotyledons, shrunken root tips and disorganized columella cells"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the LOB domain-containing protein family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous termination","sequence":"ABK28616.1","note":"Extended C-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"LOB domain-containing protein 30","featureId":"PRO_0000132281"},{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"LOB","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00291"}]},{"type":"Region","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"12068116","citationType":"journal article","authors":["Shuai B.","Reynaga-Pena C.G.","Springer P.S."],"citationCrossReferences":[{"database":"PubMed","id":"12068116"},{"database":"DOI","id":"10.1104/pp.010926"}],"title":"The LATERAL ORGAN BOUNDARIES gene defines a novel, plant-specific gene family.","publicationDate":"2002","journal":"Plant Physiol.","firstPage":"747","lastPage":"761","volume":"129"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY","GENE FAMILY","NOMENCLATURE"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"19154202","citationType":"journal article","authors":["Matsumura Y.","Iwakawa H.","Machida Y.","Machida C."],"citationCrossReferences":[{"database":"PubMed","id":"19154202"},{"database":"DOI","id":"10.1111/j.1365-313x.2009.03797.x"}],"title":"Characterization of genes in the ASYMMETRIC LEAVES2/LATERAL ORGAN BOUNDARIES (AS2/LOB) family in Arabidopsis thaliana, and functional and molecular comparisons between AS2 and other family members.","publicationDate":"2009","journal":"Plant J.","firstPage":"525","lastPage":"537","volume":"58"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"10617198","citationType":"journal article","authors":["Mayer K.F.X.","Schueller C.","Wambutt R.","Murphy G.","Volckaert G.","Pohl T.","Duesterhoeft A.","Stiekema W.","Entian K.-D.","Terryn N.","Harris B.","Ansorge W.","Brandt P.","Grivell L.A.","Rieger M.","Weichselgartner M.","de Simone V.","Obermaier B.","Mache R.","Mueller M.","Kreis M.","Delseny M.","Puigdomenech P.","Watson M.","Schmidtheini T.","Reichert B.","Portetelle D.","Perez-Alonso M.","Boutry M.","Bancroft I.","Vos P.","Hoheisel J.","Zimmermann W.","Wedler H.","Ridley P.","Langham S.-A.","McCullagh B.","Bilham L.","Robben J.","van der Schueren J.","Grymonprez B.","Chuang Y.-J.","Vandenbussche F.","Braeken M.","Weltjens I.","Voet M.","Bastiaens I.","Aert R.","Defoor E.","Weitzenegger T.","Bothe G.","Ramsperger U.","Hilbert H.","Braun M.","Holzer E.","Brandt A.","Peters S.","van Staveren M.","Dirkse W.","Mooijman P.","Klein Lankhorst R.","Rose M.","Hauf J.","Koetter P.","Berneiser S.","Hempel S.","Feldpausch M.","Lamberth S.","Van den Daele H.","De Keyser A.","Buysshaert C.","Gielen J.","Villarroel R.","De Clercq R.","van Montagu M.","Rogers J.","Cronin A.","Quail M.A.","Bray-Allen S.","Clark L.","Doggett J.","Hall S.","Kay M.","Lennard N.","McLay K.","Mayes R.","Pettett A.","Rajandream M.A.","Lyne M.","Benes V.","Rechmann S.","Borkova D.","Bloecker H.","Scharfe M.","Grimm M.","Loehnert T.-H.","Dose S.","de Haan M.","Maarse A.C.","Schaefer M.","Mueller-Auer S.","Gabel C.","Fuchs M.","Fartmann B.","Granderath K.","Dauner D.","Herzl A.","Neumann S.","Argiriou A.","Vitale D.","Liguori R.","Piravandi E.","Massenet O.","Quigley F.","Clabauld G.","Muendlein A.","Felber R.","Schnabl S.","Hiller R.","Schmidt W.","Lecharny A.","Aubourg S.","Chefdor F.","Cooke R.","Berger C.","Monfort A.","Casacuberta E.","Gibbons T.","Weber N.","Vandenbol M.","Bargues M.","Terol J.","Torres A.","Perez-Perez A.","Purnelle B.","Bent E.","Johnson S.","Tacon D.","Jesse T.","Heijnen L.","Schwarz S.","Scholler P.","Heber S.","Francs P.","Bielke C.","Frishman D.","Haase D.","Lemcke K.","Mewes H.-W.","Stocker S.","Zaccaria P.","Bevan M.","Wilson R.K.","de la Bastide M.","Habermann K.","Parnell L.","Dedhia N.","Gnoj L.","Schutz K.","Huang E.","Spiegel L.","Sekhon M.","Murray J.","Sheet P.","Cordes M.","Abu-Threideh J.","Stoneking T.","Kalicki J.","Graves T.","Harmon G.","Edwards J.","Latreille P.","Courtney L.","Cloud J.","Abbott A.","Scott K.","Johnson D.","Minx P.","Bentley D.","Fulton B.","Miller N.","Greco T.","Kemp K.","Kramer J.","Fulton L.","Mardis E.","Dante M.","Pepin K.","Hillier L.W.","Nelson J.","Spieth J.","Ryan E.","Andrews S.","Geisel C.","Layman D.","Du H.","Ali J.","Berghoff A.","Jones K.","Drone K.","Cotton M.","Joshu C.","Antonoiu B.","Zidanic M.","Strong C.","Sun H.","Lamar B.","Yordan C.","Ma P.","Zhong J.","Preston R.","Vil D.","Shekher M.","Matero A.","Shah R.","Swaby I.K.","O'Shaughnessy A.","Rodriguez M.","Hoffman J.","Till S.","Granat S.","Shohdy N.","Hasegawa A.","Hameed A.","Lodhi M.","Johnson A.","Chen E.","Marra M.A.","Martienssen R.","McCombie W.R."],"citationCrossReferences":[{"database":"PubMed","id":"10617198"},{"database":"DOI","id":"10.1038/47134"}],"title":"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.","publicationDate":"1999","journal":"Nature","firstPage":"769","lastPage":"777","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"17147637","citationType":"journal article","authors":["Underwood B.A.","Vanderhaeghen R.","Whitford R.","Town C.D.","Hilson P."],"citationCrossReferences":[{"database":"PubMed","id":"17147637"},{"database":"DOI","id":"10.1111/j.1467-7652.2006.00183.x"}],"title":"Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.","publicationDate":"2006","journal":"Plant Biotechnol. J.","firstPage":"317","lastPage":"324","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"CI-BMBMTRNO8P1ED","citationType":"submission","authors":["Quinitio C.","Chen H.","Kim C.J.","Shinn P.","Ecker J.R."],"title":"Arabidopsis ORF clones.","publicationDate":"AUG-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":8,"citation":{"id":"12040093","citationType":"journal article","authors":["Iwakawa H.","Ueno Y.","Semiarti E.","Onouchi H.","Kojima S.","Tsukaya H.","Hasebe M.","Soma T.","Ikezaki M.","Machida C.","Machida Y."],"citationCrossReferences":[{"database":"PubMed","id":"12040093"},{"database":"DOI","id":"10.1093/pcp/pcf077"}],"title":"The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana, required for formation of a symmetric flat leaf lamina, encodes a member of a novel family of proteins characterized by cysteine repeats and a leucine zipper.","publicationDate":"2002","journal":"Plant Cell Physiol.","firstPage":"467","lastPage":"478","volume":"43"},"referencePositions":["GENE FAMILY","NOMENCLATURE"]},{"referenceNumber":9,"citation":{"id":"19088331","citationType":"journal article","authors":["Soyano T.","Thitamadee S.","Machida Y.","Chua N.-H."],"citationCrossReferences":[{"database":"PubMed","id":"19088331"},{"database":"DOI","id":"10.1105/tpc.108.061796"}],"title":"ASYMMETRIC LEAVES2-LIKE19/LATERAL ORGAN BOUNDARIES DOMAIN30 and ASL20/LBD18 regulate tracheary element differentiation in Arabidopsis.","publicationDate":"2008","journal":"Plant Cell","firstPage":"3359","lastPage":"3373","volume":"20"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF432232","properties":[{"key":"ProteinId","value":"AAL27613.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB473852","properties":[{"key":"ProteinId","value":"BAH10563.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF069299","properties":[{"key":"ProteinId","value":"AAC19300.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161471","properties":[{"key":"ProteinId","value":"CAB80780.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002687","properties":[{"key":"ProteinId","value":"AEE81839.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408686","properties":[{"key":"ProteinId","value":"CAO7045590.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"DQ446787","properties":[{"key":"ProteinId","value":"ABE66037.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ653168","properties":[{"key":"ProteinId","value":"ABK28616.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT026407","properties":[{"key":"ProteinId","value":"ABH04514.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"T01350","properties":[{"key":"EntryName","value":"T01350"}]},{"database":"RefSeq","id":"NP_191933.1","properties":[{"key":"NucleotideSequenceId","value":"NM_116239.4"}]},{"database":"AlphaFoldDB","id":"O81323","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O81323","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"13375","properties":[{"key":"Interactions","value":"11"}]},{"database":"FunCoup","id":"O81323","properties":[{"key":"Number of interactors","value":"4"}]},{"database":"IntAct","id":"O81323","properties":[{"key":"Interactions","value":"6"}]},{"database":"STRING","id":"3702.O81323","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-O81323","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"250726","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"828084","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT4G00220","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT4G00220","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT4G00220","properties":[{"key":"GeneName","value":"JLO"}]},{"database":"eggNOG","id":"ENOG502QR68","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_058353_3_5_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O81323","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"STWAMQQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"O81323","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:O81323","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0001216","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37501369"}]},{"database":"GO","id":"GO:0010199","properties":[{"key":"GoTerm","value":"P:organ boundary specification between lateral organs and the meristem"},{"key":"GoEvidenceType","value":"IMP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17557810"}]},{"database":"GO","id":"GO:0010089","properties":[{"key":"GoTerm","value":"P:xylem development"},{"key":"GoEvidenceType","value":"IMP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19088331"}]},{"database":"InterPro","id":"IPR004883","properties":[{"key":"EntryName","value":"LOB"}]},{"database":"PANTHER","id":"PTHR31529","properties":[{"key":"EntryName","value":"LOB DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31529:SF4","properties":[{"key":"EntryName","value":"LOB DOMAIN-CONTAINING PROTEIN 30"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03195","properties":[{"key":"EntryName","value":"LOB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50891","properties":[{"key":"EntryName","value":"LOB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSSGNPSSSSGGGGGPCGACKFLRRKCVAGCIFAPYFDSEQGAAHFAAVHKVFGASNVSKLLHHVPEHKRPDAVVSICFEAQARLRDPIYGCVSHIVSLQQQVVSLQTELSYLQAHLATLELPQPQPPQVPVSSSGSLQALSITDLPTISPSVYDLSSIFEPVMSSTWAMQQQPRPSDHLFGVPSSSNMGGGGELQALAREFIHGGQMPAQPSPGTSGSASSVIKRE","length":228,"molWeight":23968,"crc64":"CAE3F2DA4C78A209","md5":"76A3197BE32C2C2E019A9B535BE8A1AC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":2,"TISSUE SPECIFICITY":1,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000012E247"}}