{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O75525","secondaryAccessions":["Q6NUL8","Q9UPA8"],"uniProtkbId":"KHDR3_HUMAN","entryAudit":{"firstPublicDate":"2006-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-11-01","entryVersion":204,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"KH domain-containing, RNA-binding, signal transduction-associated protein 3"}},"alternativeNames":[{"fullName":{"value":"RNA-binding protein T-Star"}},{"fullName":{"value":"Sam68-like mammalian protein 2"},"shortNames":[{"value":"SLM-2"}]},{"fullName":{"value":"Sam68-like phosphotyrosine protein"}}]},"genes":[{"geneName":{"value":"KHDRBS3"},"synonyms":[{"value":"SALP"},{"value":"SLM2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JLP1"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9R226"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10564820"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15901763"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19561594"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26758068"}],"value":"RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11741900"}],"value":"(Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JLP1"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9R226"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10332027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10564820"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10749975"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15163637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21725612"}],"value":"Self-associates to form homooligomers; dimerization increases RNA affinity (PubMed:26758068). Interacts with KHDRBS2/SLM-1 (By similarity). Interacts with KHDRBS1/SAM68; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity (PubMed:10332027). Interacts with the splicing regulatory proteins SFRS9, SAFB and YTHDC1. Interacts with HNRPL (By similarity). Interacts with RBMX, RBMY1A1, p85 subunit of PI3-kinase, SERPINB5 (PubMed:10332027, PubMed:10564820, PubMed:10749975, PubMed:21725612). Interacts with SIAH1 which promotes targeting for degradation (PubMed:15163637)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"P29972","geneName":"AQP1","intActId":"EBI-745213"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q8TBE0","geneName":"BAHD1","intActId":"EBI-742750"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q8NE01","geneName":"CNNM3","intActId":"EBI-741032"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q9NQL9","geneName":"DMRT3","intActId":"EBI-9679045"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q92608","geneName":"DOCK2","intActId":"EBI-448771"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"P02008","geneName":"HBZ","intActId":"EBI-719843"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"P61978-2","geneName":"HNRNPK","intActId":"EBI-7060731"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q92835","geneName":"INPP5D","intActId":"EBI-1380477"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q92835-2","geneName":"INPP5D","intActId":"EBI-9092209"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q07666","geneName":"KHDRBS1","intActId":"EBI-1364"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q5VWX1","geneName":"KHDRBS2","intActId":"EBI-742808"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q8IXW0","geneName":"LMNTD2","intActId":"EBI-12028858"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q6IPE9","geneName":"MARK4","intActId":"EBI-10250211"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q8IVT4","geneName":"MGC50722","intActId":"EBI-14086479"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q86VE0","geneName":"MYPOP","intActId":"EBI-2858213"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q8WX92","geneName":"NELFB","intActId":"EBI-347721"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q9Y5E9","geneName":"PCDHB14","intActId":"EBI-10329013"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q8WWY3","geneName":"PRPF31","intActId":"EBI-1567797"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"P79522","geneName":"PRR3","intActId":"EBI-2803328"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"P25786","geneName":"PSMA1","intActId":"EBI-359352"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q86YV0","geneName":"RASAL3","intActId":"EBI-3437896"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q9Y272","geneName":"RASD1","intActId":"EBI-740818"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"P98179","geneName":"RBM3","intActId":"EBI-2949699"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"P38159","geneName":"RBMX","intActId":"EBI-743526"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"P40938","geneName":"RFC3","intActId":"EBI-1055010"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q9UNE2","geneName":"RPH3AL","intActId":"EBI-2855824"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q9BYB0","geneName":"SHANK3","intActId":"EBI-1752330"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q96RF0","geneName":"SNX18","intActId":"EBI-298169"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q3SY00","geneName":"TSGA10IP","intActId":"EBI-10241197"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"P29597","geneName":"TYK2","intActId":"EBI-1383454"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q96MU7","geneName":"YTHDC1","intActId":"EBI-2849854"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q5BKZ1","geneName":"ZNF326","intActId":"EBI-2560158"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q9H9D4","geneName":"ZNF408","intActId":"EBI-347633"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q86XF7","geneName":"ZNF575","intActId":"EBI-14069183"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"Q9UK33","geneName":"ZNF580","intActId":"EBI-746277"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75525","intActId":"EBI-722504"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z5X4","geneName":"ZNF688","intActId":"EBI-16429014"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10332027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15901763"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"SALP-alpha"}],"isoformIds":["O75525-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"SALP-beta"}],"isoformIds":["O75525-2"],"sequenceIds":["VSP_017905","VSP_017906"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10077576"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10332027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10564820"}],"value":"Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11714634"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15901763"}],"value":"Induced in proteinuric diseases. Down-regulated in immortalized fibroblasts isolated after a proliferative crisis accompanied with massive cell death"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10564820"}],"value":"The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10564820"}],"value":"Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the KHDRBS family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"KH domain-containing, RNA-binding, signal transduction-associated protein 3","featureId":"PRO_0000232522"},{"type":"Domain","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"KH"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Involved in homodimerization","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26758068"}]},{"type":"Region","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"Interaction with SIAH1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15163637"}]},{"type":"Region","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Cross-link","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10564820"}],"featureId":"VSP_017905","alternativeSequence":{"originalSequence":"DY","alternativeSequences":["WC"]}},{"type":"Alternative sequence","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10564820"}],"featureId":"VSP_017906","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Fails to influence alternative splicing of CD44, NRXN2 and NRXN3.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26758068"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"Complete loss of SIAH1-mediated degradation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15163637"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Complete loss of nuclear sublocalization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11714634"}],"alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"in Ref. 3; AAH68536","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}},{"type":"Helix","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5ELT"}]},{"type":"Helix","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5ELT"}]},{"type":"Helix","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5ELT"}]},{"type":"Turn","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5ELT"}]},{"type":"Beta strand","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]},{"type":"Turn","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]},{"type":"Helix","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]},{"type":"Helix","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5ELT"}]},{"type":"Helix","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]},{"type":"Beta strand","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]},{"type":"Beta strand","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5ELS"}]},{"type":"Helix","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]},{"type":"Helix","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]},{"type":"Beta strand","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]},{"type":"Helix","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]},{"type":"Helix","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EL3"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0729","category":"Domain","name":"SH3-binding"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"10564820","citationType":"journal article","authors":["Lee J.-S.","Burr J.G."],"citationCrossReferences":[{"database":"PubMed","id":"10564820"},{"database":"DOI","id":"10.1016/s0378-1119(99)00421-7"}],"title":"Salpalpha and Salpbeta, growth-arresting homologs of Sam68.","publicationDate":"1999","journal":"Gene","firstPage":"133","lastPage":"147","volume":"240"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","NUCLEOTIDE SEQUENCE [MRNA] OF 8-346 (ISOFORM 2)","FUNCTION","TISSUE SPECIFICITY","INTERACTION WITH P85 SUBUNIT OF PI3-KINASE","PHOSPHORYLATION"],"referenceComments":[{"value":"Retina","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10332027","citationType":"journal article","authors":["Venables J.P.","Vernet C.","Chew S.L.","Elliott D.J.","Cowmeadow R.B.","Wu J.","Cooke H.J.","Artzt K.","Eperon I.C."],"citationCrossReferences":[{"database":"PubMed","id":"10332027"},{"database":"DOI","id":"10.1093/hmg/8.6.959"}],"title":"T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.","publicationDate":"1999","journal":"Hum. Mol. Genet.","firstPage":"959","lastPage":"969","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","INTERACTION WITH KHDRBS1 AND RBMX","TISSUE SPECIFICITY","SUBCELLULAR LOCATION"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-1JHOERUSSD7UO","citationType":"submission","authors":["Lubec G.","Chen W.-Q."],"publicationDate":"JAN-2009","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 45-52 AND 154-164","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"10077576","citationType":"journal article","authors":["Di Fruscio M.","Chen T.","Richard S."],"citationCrossReferences":[{"database":"PubMed","id":"10077576"},{"database":"DOI","id":"10.1073/pnas.96.6.2710"}],"title":"Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.","publicationDate":"1999","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2710","lastPage":"2715","volume":"96"},"referencePositions":["TISSUE SPECIFICITY"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"10749975","citationType":"journal article","authors":["Venables J.P.","Elliott D.J.","Makarova O.V.","Makarov E.M.","Cooke H.J.","Eperon E.C."],"citationCrossReferences":[{"database":"PubMed","id":"10749975"},{"database":"DOI","id":"10.1093/hmg/9.5.685"}],"title":"RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.","publicationDate":"2000","journal":"Hum. Mol. Genet.","firstPage":"685","lastPage":"694","volume":"9"},"referencePositions":["INTERACTION WITH RBMY1A1"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"11714634","citationType":"journal article","authors":["Kool J.","van Zaane W.","van der Eb A.J.","Terleth C."],"citationCrossReferences":[{"database":"PubMed","id":"11714634"}],"title":"Down-regulation of T-STAR, a growth inhibitory protein, after SV40-mediated immortalization.","publicationDate":"2001","journal":"Cell Growth Differ.","firstPage":"535","lastPage":"541","volume":"12"},"referencePositions":["INDUCTION","MUTAGENESIS OF 327-LYS--TYR-346"]},{"referenceNumber":8,"citation":{"id":"11741900","citationType":"journal article","authors":["Reddy T.R.","Suhasini M.","Xu W.","Yeh L.-Y.","Yang J.-P.","Wu J.","Artzt K.","Wong-Staal F."],"citationCrossReferences":[{"database":"PubMed","id":"11741900"},{"database":"DOI","id":"10.1074/jbc.m106836200"}],"title":"A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"5778","lastPage":"5784","volume":"277"},"referencePositions":["FUNCTION"]},{"referenceNumber":9,"citation":{"id":"15163637","citationType":"journal article","authors":["Venables J.P.","Dalgliesh C.","Paronetto M.P.","Skitt L.","Thornton J.K.","Saunders P.T.","Sette C.","Jones K.T.","Elliott D.J."],"citationCrossReferences":[{"database":"PubMed","id":"15163637"},{"database":"DOI","id":"10.1093/hmg/ddh165"}],"title":"SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome.","publicationDate":"2004","journal":"Hum. Mol. Genet.","firstPage":"1525","lastPage":"1534","volume":"13"},"referencePositions":["INTERACTION WITH SIAH1","DOMAIN","MUTAGENESIS OF 212-ARG--PRO-251"]},{"referenceNumber":10,"citation":{"id":"15901763","citationType":"journal article","authors":["Cohen C.D.","Doran P.P.","Blattner S.M.","Merkle M.","Wang G.Q.","Schmid H.","Mathieson P.W.","Saleem M.A.","Henger A.","Rastaldi M.P.","Kretzler M."],"citationCrossReferences":[{"database":"PubMed","id":"15901763"},{"database":"DOI","id":"10.1681/asn.2005020204"}],"title":"Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor.","publicationDate":"2005","journal":"J. Am. Soc. Nephrol.","firstPage":"1958","lastPage":"1965","volume":"16"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION","FUNCTION"]},{"referenceNumber":11,"citation":{"id":"19561594","citationType":"journal article","authors":["Ray D.","Kazan H.","Chan E.T.","Pena Castillo L.","Chaudhry S.","Talukder S.","Blencowe B.J.","Morris Q.","Hughes T.R."],"citationCrossReferences":[{"database":"PubMed","id":"19561594"},{"database":"DOI","id":"10.1038/nbt.1550"}],"title":"Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.","publicationDate":"2009","journal":"Nat. Biotechnol.","firstPage":"667","lastPage":"670","volume":"27"},"referencePositions":["RNA-BINDING"]},{"referenceNumber":12,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"21725612","citationType":"journal article","authors":["Lei K.F.","Liu B.Y.","Wang Y.F.","Chen X.H.","Yu B.Q.","Guo Y.","Zhu Z.G."],"citationCrossReferences":[{"database":"PubMed","id":"21725612"},{"database":"DOI","id":"10.3892/or.2011.1369"}],"title":"SerpinB5 interacts with KHDRBS3 and FBXO32 in gastric cancer cells.","publicationDate":"2011","journal":"Oncol. Rep.","firstPage":"1115","lastPage":"1120","volume":"26"},"referencePositions":["INTERACTION WITH SERPINB5"]},{"referenceNumber":14,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-4","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"26758068","citationType":"journal article","authors":["Feracci M.","Foot J.N.","Grellscheid S.N.","Danilenko M.","Stehle R.","Gonchar O.","Kang H.S.","Dalgliesh C.","Meyer N.H.","Liu Y.","Lahat A.","Sattler M.","Eperon I.C.","Elliott D.J.","Dominguez C."],"citationCrossReferences":[{"database":"PubMed","id":"26758068"},{"database":"DOI","id":"10.1038/ncomms10355"}],"title":"Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.","publicationDate":"2016","journal":"Nat. Commun.","firstPage":"10355","lastPage":"10355","volume":"7"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS) OF 1-183 IN COMPLEX WITH RNA SUBSTRATES","FUNCTION","MUTAGENESIS OF TYR-141","SELF-ASSOCIATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF051321","properties":[{"key":"ProteinId","value":"AAC99294.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF051322","properties":[{"key":"ProteinId","value":"AAC99295.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF069681","properties":[{"key":"ProteinId","value":"AAC24857.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC032606","properties":[{"key":"ProteinId","value":"AAH32606.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC068536","properties":[{"key":"ProteinId","value":"AAH68536.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS6374.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O75525-1"},{"database":"RefSeq","id":"NP_006549.1","properties":[{"key":"NucleotideSequenceId","value":"NM_006558.3"}],"isoformId":"O75525-1"},{"database":"PDB","id":"5EL3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A/B/C/D=50-160"}]},{"database":"PDB","id":"5ELR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"C/D=50-183"}]},{"database":"PDB","id":"5ELS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.87 A"},{"key":"Chains","value":"A/B/C/D/E/F=50-160"}]},{"database":"PDB","id":"5ELT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.13 A"},{"key":"Chains","value":"A/B=1-160"}]},{"database":"PDB","id":"5EMO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.03 A"},{"key":"Chains","value":"A/B=1-183"}]},{"database":"PDBsum","id":"5EL3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5ELR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5ELS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5ELT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5EMO","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"115899","properties":[{"key":"Interactions","value":"103"}]},{"database":"FunCoup","id":"O75525","properties":[{"key":"Number of interactors","value":"1266"}]},{"database":"IntAct","id":"O75525","properties":[{"key":"Interactions","value":"83"}]},{"database":"MINT","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"MUSIC2-C5228-KHDRBS3","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - RNA metabolism and nuclear transport regulation (23 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000348108","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"O75525","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"KHDRBS3","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000348108","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"50061","properties":[{"key":"Description","value":"-"}],"isoformId":"O75525-1"},{"database":"ProteomicsDB","id":"50062","properties":[{"key":"Description","value":"-"}],"isoformId":"O75525-2"},{"database":"Pumba","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"O75525-2","properties":[{"key":"Description","value":"-"}],"isoformId":"O75525-2"},{"database":"Antibodypedia","id":"612","properties":[{"key":"antibodies","value":"197 antibodies from 28 providers"}]},{"database":"DNASU","id":"10656","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000355849.10","properties":[{"key":"ProteinId","value":"ENSP00000348108.5"},{"key":"GeneId","value":"ENSG00000131773.15"}],"isoformId":"O75525-1"},{"database":"GeneID","id":"10656","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:10656","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000355849.10","properties":[{"key":"ProteinId","value":"ENSP00000348108.5"},{"key":"RefSeqNucleotideId","value":"NM_006558.3"},{"key":"RefSeqProteinId","value":"NP_006549.1"}]},{"database":"UCSC","id":"uc003yuv.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"O75525-1"},{"database":"AGR","id":"HGNC:18117","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30094","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10656","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10656","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"KHDRBS3","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:18117","properties":[{"key":"GeneName","value":"KHDRBS3"}]},{"database":"HPA","id":"ENSG00000131773","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (testis)"}]},{"database":"MIM","id":"610421","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000131773","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000131773","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1588","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157280","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_034976_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"SYREQPY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6777263at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O75525","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-8849468","properties":[{"key":"PathwayName","value":"PTK6 Regulates Proteins Involved in RNA Processing"}]},{"database":"SignaLink","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000131773","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"10656","properties":[{"key":"hits","value":"11 hits in 1151 CRISPR screens"}]},{"database":"CD-CODE","id":"62EA6512","properties":[{"key":"EntryName","value":"Sam68 nuclear body"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"ChiTaRS","id":"KHDRBS3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"O75525","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"KHDRBS3","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"10656","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O75525","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:O75525","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"O75525","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000131773","properties":[{"key":"ExpressionPatterns","value":"Expressed in cortical plate and 190 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O75525","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10332027"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10332027"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10749975"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10332027"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10749975"}]},{"database":"GO","id":"GO:0019904","properties":[{"key":"GoTerm","value":"F:protein domain specific binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10332027"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10749975"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19561594"}]},{"database":"GO","id":"GO:0000381","properties":[{"key":"GoTerm","value":"P:regulation of alternative mRNA splicing, via spliceosome"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd22470","properties":[{"key":"EntryName","value":"KH-I_KHDRBS3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1370.10:FF:000030","properties":[{"key":"EntryName","value":"KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoformX2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1370.10","properties":[{"key":"EntryName","value":"K Homology domain, type 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045071","properties":[{"key":"EntryName","value":"BBP-like"}]},{"database":"InterPro","id":"IPR055256","properties":[{"key":"EntryName","value":"KH_1_KHDC4/BBP-like"}]},{"database":"InterPro","id":"IPR004087","properties":[{"key":"EntryName","value":"KH_dom"}]},{"database":"InterPro","id":"IPR036612","properties":[{"key":"EntryName","value":"KH_dom_type_1_sf"}]},{"database":"InterPro","id":"IPR032571","properties":[{"key":"EntryName","value":"Qua1_dom"}]},{"database":"InterPro","id":"IPR032335","properties":[{"key":"EntryName","value":"Sam68-YY"}]},{"database":"PANTHER","id":"PTHR11208:SF29","properties":[{"key":"EntryName","value":"KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11208","properties":[{"key":"EntryName","value":"RNA-BINDING PROTEIN RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22675","properties":[{"key":"EntryName","value":"KH-I_KHDC4-BBP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16274","properties":[{"key":"EntryName","value":"Qua1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16568","properties":[{"key":"EntryName","value":"Sam68-YY"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00322","properties":[{"key":"EntryName","value":"KH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54791","properties":[{"key":"EntryName","value":"Eukaryotic type KH-domain (KH-domain type I)"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEEKYLPELMAEKDSLDPSFTHALRLVNQEIEKFQKGEGKDEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKPTLRTRGVPAPAITRGRGGVTARPVGVVVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSGADYYDYGHGLSEETYDSYGQEEWTNSRHKAPSARTAKGVYRDQPYGRY","length":346,"molWeight":38800,"crc64":"CA37968A4DF6D573","md5":"AD5537476A939B5F430F30414F1BB72C"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"INTERACTION":36,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":4,"Compositional bias":2,"Cross-link":1,"Alternative sequence":2,"Mutagenesis":3,"Sequence conflict":1,"Helix":10,"Turn":2,"Beta strand":4},"uniParcId":"UPI0000073E6F"}}