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Interacts (via IBD domain) with KMT2A (via IBM motifs) with a moderate affinity whereas interacts with the KMT2A-MEN1 complex with a greater affinity; MEN1 enhances interaction of KMT2A with PSIP1 (PubMed:22327296, PubMed:25082813, PubMed:25305204, PubMed:29997176). Interacts with fusion protein KMT2A-MLLT3 (PubMed:25305204). Interacts (via IBD domain) with IWS1 (via IBM motif), MED1 (via IBM motif) and DBF4 (via IBM motifs) (PubMed:29997176)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15475359"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15749713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15797927"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15895093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19244240"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25082813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25305204"}],"value":"(Microbial infection) Interacts (via IBD domain) with human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome"}],"commentType":"SUBUNIT","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15749713"}],"value":"(Microbial infection) Interacts with HIV-2 IN"}],"commentType":"SUBUNIT","molecule":"Isoform 1"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O75475","intActId":"EBI-1801773"},"interactantTwo":{"uniProtKBAccession":"Q99708","geneName":"RBBP8","intActId":"EBI-745715"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75475","intActId":"EBI-1801773"},"interactantTwo":{"uniProtKBAccession":"P63165","geneName":"SUMO1","intActId":"EBI-80140"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75475","intActId":"EBI-1801773"},"interactantTwo":{"uniProtKBAccession":"P04585","geneName":"gag-pol","intActId":"EBI-3989067"},"numberOfExperiments":21,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O75475-1","intActId":"EBI-5279836"},"interactantTwo":{"uniProtKBAccession":"P04585","geneName":"gag-pol","chainId":"PRO_0000042447","intActId":"EBI-9872653"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O75475-1","intActId":"EBI-5279836"},"interactantTwo":{"uniProtKBAccession":"P12497","geneName":"gag-pol","chainId":"PRO_0000042402","intActId":"EBI-10131955"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Remains chromatin-associated throughout the cell cycle"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15642333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9885563"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"p75"},{"value":"PSIP1"}],"isoformIds":["O75475-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"p52"},{"value":"PSIP2"}],"isoformIds":["O75475-2"],"sequenceIds":["VSP_014297","VSP_014298"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["O75475-3"],"sequenceIds":["VSP_044435"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15642333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822615"}],"value":"Widely expressed. 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