ID   TECTA_HUMAN             Reviewed;        2155 AA.
AC   O75443;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 3.
DT   24-JAN-2024, entry version 190.
DE   RecName: Full=Alpha-tectorin;
DE   Flags: Precursor;
GN   Name=TECTA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS DFNA12 PHE-1820; ASP-1824 AND
RP   CYS-1870, AND VARIANTS GLY-371; ALA-932 AND ASN-1724.
RX   PubMed=9590290; DOI=10.1038/ng0598-60;
RA   Verhoeven K., Van Laer L., Kirschhofer K., Legan P.K., Hughes D.C.,
RA   Schatteman I., Verstreken M., Van Hauwe P., Coucke P., Chen A.,
RA   Smith R.J.H., Somers T., Offeciers F.E., Van de Heyning P.,
RA   Richardson G.P., Wachtler F., Kimberling W.J., Willems P.J., Govaerts P.J.,
RA   Van Camp G.;
RT   "Mutations in the human alpha-tectorin gene cause autosomal dominant non-
RT   syndromic hearing impairment.";
RL   Nat. Genet. 19:60-62(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   INTERACTION WITH CEACAM16.
RX   PubMed=21368133; DOI=10.1073/pnas.1005842108;
RA   Zheng J., Miller K.K., Yang T., Hildebrand M.S., Shearer A.E., DeLuca A.P.,
RA   Scheetz T.E., Drummond J., Scherer S.E., Legan P.K., Goodyear R.J.,
RA   Richardson G.P., Cheatham M.A., Smith R.J., Dallos P.;
RT   "Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with
RT   alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:4218-4223(2011).
RN   [4]
RP   VARIANT DFNA12 SER-1619.
RX   PubMed=10196713; DOI=10.1038/sj.ejhg.5200273;
RA   Alloisio N., Morle L., Bozon M., Godet J., Verhoeven K., Van Camp G.,
RA   Plauchu H., Muller P., Collet L., Lina-Granade G.;
RT   "Mutation in the zonadhesin-like domain of alpha-tectorin associated with
RT   autosomal dominant non-syndromic hearing loss.";
RL   Eur. J. Hum. Genet. 7:255-258(1999).
RN   [5]
RP   VARIANT DFNA12 SER-1057, AND VARIANTS GLY-371; ALA-932 AND THR-2100.
RX   PubMed=10987647; DOI=10.1007/s004390051091;
RA   Balciuniene J., Dahl N., Jalonen P., Verhoeven K., Van Camp G., Borg E.,
RA   Pettersson U., Jazin E.E.;
RT   "Alpha-tectorin involvement in hearing disabilities: one gene -- two
RT   phenotypes.";
RL   Hum. Genet. 105:211-216(1999).
RN   [6]
RP   INVOLVEMENT IN DFNB21.
RX   PubMed=9949200; DOI=10.1093/hmg/8.3.409;
RA   Mustapha M., Weil D., Chardenoux S., Elias S., El-Zir E., Beckmann J.S.,
RA   Loiselet J., Petit C.;
RT   "An alpha-tectorin gene defect causes a newly identified autosomal
RT   recessive form of sensorineural pre-lingual non-syndromic deafness,
RT   DFNB21.";
RL   Hum. Mol. Genet. 8:409-412(1999).
RN   [7]
RP   VARIANT GLY-1837.
RX   PubMed=11333869; DOI=10.1136/jmg.38.5.e13;
RA   Moreno-Pelayo M.A., del Castillo I., Villamar M., Romero L.,
RA   Hernandez-Calvin F.J., Herraiz C., Barbera R., Navas C., Moreno F.;
RT   "A cysteine substitution in the zona pellucida domain of alpha-tectorin
RT   results in autosomal dominant, postlingual, progressive, mid frequency
RT   hearing loss in a Spanish family.";
RL   J. Med. Genet. 38:E13-E13(2001).
RN   [8]
RP   VARIANT DFNA12 HIS-2021.
RX   PubMed=12162770; DOI=10.1001/archotol.128.8.913;
RA   Iwasaki S., Harada D., Usami S., Nagura M., Takeshita T., Hoshino T.;
RT   "Association of clinical features with mutation of TECTA in a family with
RT   autosomal dominant hearing loss.";
RL   Arch. Otolaryngol. Head Neck Surg. 128:913-917(2002).
RN   [9]
RP   INVOLVEMENT IN DFNB21.
RX   PubMed=12746400; DOI=10.1136/jmg.40.5.360;
RA   Naz S., Alasti F., Mowjoodi A., Riazuddin S., Sanati M.H., Friedman T.B.,
RA   Griffith A.J., Wilcox E.R., Riazuddin S.;
RT   "Distinctive audiometric profile associated with DFNB21 alleles of TECTA.";
RL   J. Med. Genet. 40:360-363(2003).
RN   [10]
RP   VARIANT DFNA12 GLY-1509.
RX   PubMed=15319541; DOI=10.1159/000080347;
RA   Pfister M., Thiele H., Van Camp G., Fransen E., Apaydin F., Aydin O.,
RA   Leistenschneider P., Devoto M., Zenner H.P., Blin N., Nurnberg P.,
RA   Ozkarakas H., Kupka S.;
RT   "A genotype-phenotype correlation with gender-effect for hearing impairment
RT   caused by TECTA mutations.";
RL   Cell. Physiol. Biochem. 14:369-376(2004).
RN   [11]
RP   VARIANT DFNA12 CYS-1890.
RX   PubMed=16718611; DOI=10.1007/s10162-006-0033-z;
RA   Plantinga R.F., de Brouwer A.P., Huygen P.L., Kunst H.P., Kremer H.,
RA   Cremers C.W.;
RT   "A novel TECTA mutation in a Dutch DFNA8/12 family confirms genotype-
RT   phenotype correlation.";
RL   J. Assoc. Res. Otolaryngol. 7:173-181(2006).
RN   [12]
RP   VARIANTS [LARGE SCALE ANALYSIS] HIS-284; ASN-771 AND THR-813.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
RN   [13]
RP   VARIANT DFNA12 ARG-1837.
RX   PubMed=17661817; DOI=10.1111/j.1399-0004.2007.00828.x;
RA   Meyer N.C., Nishimura C.J., McMordie S., Smith R.J.;
RT   "Audioprofiling identifies TECTA and GJB2-related deafness segregating in a
RT   single extended pedigree.";
RL   Clin. Genet. 72:130-137(2007).
RN   [14]
RP   VARIANTS DFNA12 GLU-317 AND MET-1866.
RX   PubMed=20947814;
RA   Sagong B., Park R., Kim Y.H., Lee K.Y., Baek J.I., Cho H.J., Cho I.J.,
RA   Kim U.K., Lee S.H.;
RT   "Two novel missense mutations in the TECTA gene in Korean families with
RT   autosomal dominant nonsyndromic hearing loss.";
RL   Ann. Clin. Lab. Sci. 40:380-385(2010).
RN   [15]
RP   VARIANTS DFNA12 ASN-197; SER-211; CYS-362; LYS-465; MET-562; MET-815;
RP   SER-886; TYR-1036; VAL-1098; HIS-1136; LEU-1248; ARG-1517; ARG-1791;
RP   GLY-1837; MET-1866; ARG-1867; CYS-1890; ARG-1898; CYS-1947 AND THR-2009.
RX   PubMed=21520338; DOI=10.1002/humu.21512;
RA   Hildebrand M.S., Morin M., Meyer N.C., Mayo F., Modamio-Hoybjor S.,
RA   Mencia A., Olavarrieta L., Morales-Angulo C., Nishimura C.J., Workman H.,
RA   DeLuca A.P., del Castillo I., Taylor K.R., Tompkins B., Goodman C.W.,
RA   Schrauwen I., Wesemael M.V., Lachlan K., Shearer A.E., Braun T.A.,
RA   Huygen P.L., Kremer H., Van Camp G., Moreno F., Casavant T.L., Smith R.J.,
RA   Moreno-Pelayo M.A.;
RT   "DFNA8/12 caused by TECTA mutations is the most identified subtype of
RT   nonsyndromic autosomal dominant hearing loss.";
RL   Hum. Mutat. 32:825-834(2011).
CC   -!- FUNCTION: One of the major non-collagenous components of the tectorial
CC       membrane (By similarity). The tectorial membrane is an extracellular
CC       matrix of the inner ear that covers the neuroepithelium of the cochlea
CC       and contacts the stereocilia bundles of specialized sensory hair cells.
CC       Sound induces movement of these hair cells relative to the tectorial
CC       membrane, deflects the stereocilia and leads to fluctuations in hair-
CC       cell membrane potential, transducing sound into electrical signals.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: May form homomeric filament after self-association or
CC       heteromeric filament after association with beta-tectorin (Probable).
CC       Interacts with CEACAM16. {ECO:0000269|PubMed:21368133, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted,
CC       extracellular space, extracellular matrix. Note=Found in the non-
CC       collagenous matrix of the tectorial membrane. {ECO:0000250}.
CC   -!- DOMAIN: Zona pellucida domain may enable to form filaments.
CC   -!- PTM: The presence of a hydrophobic C-terminus preceded by a potential
CC       cleavage site strongly suggests that tectorins are synthesized as
CC       glycosylphosphatidylinositol-linked, membrane-bound precursors.
CC       Tectorins are targeted to the apical surface of the inner ear epithelia
CC       by the lipid and proteolytically released into the extracellular
CC       compartment.
CC   -!- DISEASE: Deafness, autosomal dominant, 12 (DFNA12) [MIM:601543]: A form
CC       of non-syndromic sensorineural hearing loss. Sensorineural deafness
CC       results from damage to the neural receptors of the inner ear, the nerve
CC       pathways to the brain, or the area of the brain that receives sound
CC       information. {ECO:0000269|PubMed:12746400, ECO:0000269|PubMed:9949200}.
CC       Note=The disease is caused by variants affecting the gene represented
CC       in this entry.
CC   -!- DISEASE: Deafness, autosomal recessive, 21 (DFNB21) [MIM:603629]: A
CC       form of non-syndromic sensorineural hearing loss. Sensorineural
CC       deafness results from damage to the neural receptors of the inner ear,
CC       the nerve pathways to the brain, or the area of the brain that receives
CC       sound information. {ECO:0000269|PubMed:12746400,
CC       ECO:0000269|PubMed:9949200}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
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DR   EMBL; AF055136; AAC26019.1; -; Genomic_DNA.
DR   EMBL; AF055114; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055115; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055116; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055117; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055118; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055119; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055120; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055121; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055122; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055123; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055124; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055125; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055126; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055127; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055128; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055129; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055130; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055131; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055132; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055133; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055134; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AF055135; AAC26019.1; JOINED; Genomic_DNA.
DR   EMBL; AP000646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS8434.1; -.
DR   RefSeq; NP_005413.2; NM_005422.2.
DR   AlphaFoldDB; O75443; -.
DR   SMR; O75443; -.
DR   BioGRID; 112866; 8.
DR   IntAct; O75443; 2.
DR   MINT; O75443; -.
DR   STRING; 9606.ENSP00000376543; -.
DR   TCDB; 9.B.87.1.35; the selenoprotein p receptor (selp-receptor) family.
DR   GlyCosmos; O75443; 30 sites, No reported glycans.
DR   GlyGen; O75443; 30 sites.
DR   iPTMnet; O75443; -.
DR   PhosphoSitePlus; O75443; -.
DR   BioMuta; TECTA; -.
DR   MassIVE; O75443; -.
DR   PaxDb; 9606-ENSP00000376543; -.
DR   PeptideAtlas; O75443; -.
DR   ProteomicsDB; 50008; -.
DR   Antibodypedia; 18890; 33 antibodies from 15 providers.
DR   DNASU; 7007; -.
DR   Ensembl; ENST00000264037.2; ENSP00000264037.2; ENSG00000109927.11.
DR   Ensembl; ENST00000392793.6; ENSP00000376543.1; ENSG00000109927.11.
DR   GeneID; 7007; -.
DR   KEGG; hsa:7007; -.
DR   MANE-Select; ENST00000392793.6; ENSP00000376543.1; NM_005422.4; NP_005413.2.
DR   UCSC; uc010rzo.2; human.
DR   AGR; HGNC:11720; -.
DR   CTD; 7007; -.
DR   DisGeNET; 7007; -.
DR   GeneCards; TECTA; -.
DR   GeneReviews; TECTA; -.
DR   HGNC; HGNC:11720; TECTA.
DR   HPA; ENSG00000109927; Low tissue specificity.
DR   MalaCards; TECTA; -.
DR   MIM; 601543; phenotype.
DR   MIM; 602574; gene.
DR   MIM; 603629; phenotype.
DR   neXtProt; NX_O75443; -.
DR   OpenTargets; ENSG00000109927; -.
DR   Orphanet; 90635; Rare autosomal dominant non-syndromic sensorineural deafness type DFNA.
DR   Orphanet; 90636; Rare autosomal recessive non-syndromic sensorineural deafness type DFNB.
DR   VEuPathDB; HostDB:ENSG00000109927; -.
DR   eggNOG; KOG1216; Eukaryota.
DR   eggNOG; KOG4291; Eukaryota.
DR   GeneTree; ENSGT00950000183155; -.
DR   HOGENOM; CLU_001423_0_0_1; -.
DR   InParanoid; O75443; -.
DR   OMA; RVQTGCV; -.
DR   OrthoDB; 2872912at2759; -.
DR   PhylomeDB; O75443; -.
DR   TreeFam; TF300299; -.
DR   PathwayCommons; O75443; -.
DR   Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR   SignaLink; O75443; -.
DR   BioGRID-ORCS; 7007; 5 hits in 1145 CRISPR screens.
DR   ChiTaRS; TECTA; human.
DR   GeneWiki; TECTA; -.
DR   GenomeRNAi; 7007; -.
DR   Pharos; O75443; Tbio.
DR   PRO; PR:O75443; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; O75443; Protein.
DR   Bgee; ENSG00000109927; Expressed in oocyte and 132 other cell types or tissues.
DR   ExpressionAtlas; O75443; baseline and differential.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR   GO; GO:0060088; P:auditory receptor cell stereocilium organization; IEA:Ensembl.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; TAS:ProtInc.
DR   CDD; cd19941; TIL; 3.
DR   Gene3D; 2.10.25.10; Laminin; 4.
DR   Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR   Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR003886; NIDO_dom.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR025615; TILa_dom.
DR   InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   InterPro; IPR042235; ZP-C.
DR   InterPro; IPR001507; ZP_dom.
DR   InterPro; IPR017977; ZP_dom_CS.
DR   PANTHER; PTHR46160:SF3; ALPHA-TECTORIN; 1.
DR   PANTHER; PTHR46160; ALPHA-TECTORIN-RELATED; 1.
DR   Pfam; PF08742; C8; 4.
DR   Pfam; PF06119; NIDO; 1.
DR   Pfam; PF01826; TIL; 3.
DR   Pfam; PF12714; TILa; 2.
DR   Pfam; PF00094; VWD; 4.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   SMART; SM00832; C8; 4.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00539; NIDO; 1.
DR   SMART; SM00215; VWC_out; 3.
DR   SMART; SM00216; VWD; 4.
DR   SMART; SM00241; ZP; 1.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 3.
DR   PROSITE; PS51220; NIDO; 1.
DR   PROSITE; PS51233; VWFD; 4.
DR   PROSITE; PS00682; ZP_1; 1.
DR   PROSITE; PS51034; ZP_2; 1.
DR   Genevisible; O75443; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Deafness; Disease variant; Disulfide bond;
KW   Extracellular matrix; Glycoprotein; GPI-anchor; Hearing; Lipoprotein;
KW   Membrane; Non-syndromic deafness; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..2091
FT                   /note="Alpha-tectorin"
FT                   /id="PRO_0000041735"
FT   PROPEP          2092..2155
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000041736"
FT   DOMAIN          98..252
FT                   /note="NIDO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00570"
FT   DOMAIN          260..314
FT                   /note="VWFC"
FT   DOMAIN          320..500
FT                   /note="VWFD 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          597..650
FT                   /note="TIL 1"
FT   DOMAIN          711..886
FT                   /note="VWFD 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          984..1036
FT                   /note="TIL 2"
FT   DOMAIN          1098..1278
FT                   /note="VWFD 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          1372..1425
FT                   /note="TIL 3"
FT   DOMAIN          1485..1666
FT                   /note="VWFD 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          1805..2059
FT                   /note="ZP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00375"
FT   LIPID           2091
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        187
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        215
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        278
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        455
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        506
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        528
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        560
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        670
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        687
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        813
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        843
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        855
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        898
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        920
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        931
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        949
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1048
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1235
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1364
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1538
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1565
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1756
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1772
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1794
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1851
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1864
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1880
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1920
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1939
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        322..461
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        344..499
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        713..849
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1100..1241
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1122..1277
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1487..1622
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1509..1665
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1717..1775
FT                   /evidence="ECO:0000250|UniProtKB:P07911"
FT   DISULFID        1741..1784
FT                   /evidence="ECO:0000250|UniProtKB:P07911"
FT   DISULFID        1786..1818
FT                   /evidence="ECO:0000250|UniProtKB:P07911"
FT   DISULFID        1806..1898
FT                   /evidence="ECO:0000250|UniProtKB:P07911"
FT   DISULFID        1837..1857
FT                   /evidence="ECO:0000250|UniProtKB:P07911"
FT   DISULFID        1980..2040
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2001..2056
FT                   /evidence="ECO:0000250|UniProtKB:P07911"
FT   DISULFID        2045..2052
FT                   /evidence="ECO:0000250|UniProtKB:P07911"
FT   VARIANT         19
FT                   /note="Q -> R (in dbSNP:rs35507522)"
FT                   /id="VAR_057500"
FT   VARIANT         197
FT                   /note="D -> N (in DFNA12)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066076"
FT   VARIANT         211
FT                   /note="F -> S (in DFNA12)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066077"
FT   VARIANT         284
FT                   /note="R -> H (in a breast cancer sample; somatic mutation;
FT                   dbSNP:rs886047837)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036423"
FT   VARIANT         317
FT                   /note="V -> E (in DFNA12)"
FT                   /evidence="ECO:0000269|PubMed:20947814"
FT                   /id="VAR_066078"
FT   VARIANT         362
FT                   /note="S -> C (in DFNA12; dbSNP:rs779123206)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066079"
FT   VARIANT         371
FT                   /note="R -> G (in dbSNP:rs612969)"
FT                   /evidence="ECO:0000269|PubMed:10987647,
FT                   ECO:0000269|PubMed:9590290"
FT                   /id="VAR_018968"
FT   VARIANT         465
FT                   /note="N -> K (in DFNA12)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066080"
FT   VARIANT         562
FT                   /note="T -> M (in DFNA12; dbSNP:rs779401654)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066081"
FT   VARIANT         771
FT                   /note="I -> N (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036424"
FT   VARIANT         813
FT                   /note="N -> T (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036425"
FT   VARIANT         815
FT                   /note="T -> M (in DFNA12; dbSNP:rs111759871)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066082"
FT   VARIANT         886
FT                   /note="N -> S (in DFNA12; dbSNP:rs146175803)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066083"
FT   VARIANT         932
FT                   /note="V -> A (in dbSNP:rs520805)"
FT                   /evidence="ECO:0000269|PubMed:10987647,
FT                   ECO:0000269|PubMed:9590290"
FT                   /id="VAR_018969"
FT   VARIANT         1036
FT                   /note="C -> Y (in DFNA12; dbSNP:rs772606235)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066084"
FT   VARIANT         1057
FT                   /note="C -> S (in DFNA12; progressive deafness with late
FT                   onset; dbSNP:rs121909059)"
FT                   /evidence="ECO:0000269|PubMed:10987647"
FT                   /id="VAR_018970"
FT   VARIANT         1098
FT                   /note="A -> V (in DFNA12; dbSNP:rs761524812)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066085"
FT   VARIANT         1136
FT                   /note="D -> H (in DFNA12; dbSNP:rs147890616)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066086"
FT   VARIANT         1248
FT                   /note="P -> L (in DFNA12; dbSNP:rs138768918)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066087"
FT   VARIANT         1509
FT                   /note="C -> G (in DFNA12)"
FT                   /evidence="ECO:0000269|PubMed:15319541"
FT                   /id="VAR_066088"
FT   VARIANT         1517
FT                   /note="C -> R (in DFNA12)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066089"
FT   VARIANT         1584
FT                   /note="S -> T (in dbSNP:rs34963131)"
FT                   /id="VAR_057501"
FT   VARIANT         1619
FT                   /note="C -> S (in DFNA12; dbSNP:rs121909060)"
FT                   /evidence="ECO:0000269|PubMed:10196713"
FT                   /id="VAR_018971"
FT   VARIANT         1724
FT                   /note="S -> N (in dbSNP:rs526433)"
FT                   /evidence="ECO:0000269|PubMed:9590290"
FT                   /id="VAR_018972"
FT   VARIANT         1791
FT                   /note="P -> R (in DFNA12; dbSNP:rs754213928)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066090"
FT   VARIANT         1820
FT                   /note="L -> F (in DFNA12; prelingual and stable deafness;
FT                   dbSNP:rs281865415)"
FT                   /evidence="ECO:0000269|PubMed:9590290"
FT                   /id="VAR_018973"
FT   VARIANT         1824
FT                   /note="G -> D (in DFNA12; prelingual and stable deafness;
FT                   dbSNP:rs267607107)"
FT                   /evidence="ECO:0000269|PubMed:9590290"
FT                   /id="VAR_018974"
FT   VARIANT         1837
FT                   /note="C -> G (in DFNA12; postlingual and progressive;
FT                   dbSNP:rs121909061)"
FT                   /evidence="ECO:0000269|PubMed:11333869,
FT                   ECO:0000269|PubMed:21520338"
FT                   /id="VAR_018975"
FT   VARIANT         1837
FT                   /note="C -> R (in DFNA12; dbSNP:rs121909061)"
FT                   /evidence="ECO:0000269|PubMed:17661817"
FT                   /id="VAR_066091"
FT   VARIANT         1866
FT                   /note="T -> M (in DFNA12; dbSNP:rs140236996)"
FT                   /evidence="ECO:0000269|PubMed:20947814,
FT                   ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066092"
FT   VARIANT         1867
FT                   /note="H -> R (in DFNA12)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066093"
FT   VARIANT         1870
FT                   /note="Y -> C (in DFNA12; prelingual and stable deafness;
FT                   dbSNP:rs121909058)"
FT                   /evidence="ECO:0000269|PubMed:9590290"
FT                   /id="VAR_018976"
FT   VARIANT         1878
FT                   /note="S -> R (in dbSNP:rs202045605)"
FT                   /id="VAR_059965"
FT   VARIANT         1890
FT                   /note="R -> C (in DFNA12; dbSNP:rs121909063)"
FT                   /evidence="ECO:0000269|PubMed:16718611,
FT                   ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066094"
FT   VARIANT         1898
FT                   /note="C -> R (in DFNA12)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066095"
FT   VARIANT         1947
FT                   /note="R -> C (in DFNA12; dbSNP:rs1428598791)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066096"
FT   VARIANT         2009
FT                   /note="I -> T (in DFNA12)"
FT                   /evidence="ECO:0000269|PubMed:21520338"
FT                   /id="VAR_066097"
FT   VARIANT         2021
FT                   /note="R -> H (in DFNA12; prelingual and stable deafness;
FT                   dbSNP:rs121909062)"
FT                   /evidence="ECO:0000269|PubMed:12162770"
FT                   /id="VAR_018977"
FT   VARIANT         2100
FT                   /note="S -> T"
FT                   /evidence="ECO:0000269|PubMed:10987647"
FT                   /id="VAR_018978"
SQ   SEQUENCE   2155 AA;  239527 MW;  A7CB1CD9E7C594C3 CRC64;
     MNYSSFLRIW VSFIFALVQH QAQPRELMYP FWQNDTKTPK VDDGSSSEIK LAIPVFFFGV
     PYRTVYVNNN GVVSFNVLVS QFTPESFPLT DGRAFVAPFW ADVHNGIRGE IYYRETMEPA
     ILKRATKDIR KYFKDMATFS ATWVFIVTWE EVTFYGGSST TPVNTFQAVL VSDGSYTFTL
     FNYYEINWTT GTASGGDPLT GLGGVMAQAG FNGGNLTNFF SLPGSRTPEI VNIQETTNVN
     VPGRWAFKVD GKEIDPANGC TSRGQFLRRG EVFWDDLNCT VKCRCLDFNN EIYCQEASCS
     PYEVCEPKGK FFYCSAVETS TCVVFGEPHY HTFDGFLFHF QGSCAYLLAR QCLQTSSLPF
     FSVEAKNEHR RGSAVSWVKE LSVEVNGYKI LIPKGSYGRV KVNDLVTSLP VTLDLGTVKI
     YQSGISTAVE TDFGLLVTFD GQHYASISVP GSYINSTCGL CGNYNKNPLD DFLRPDGRPA
     MSVLDLGESW RVYHADWKCD SGCVDNCTQC DAATEALYFG SDYCGFLNKT DGPLWECGTV
     VDPTAFVHSC VYDLCSVRDN GTLLCQAIQA YALVCQALGI PIGDWRTQTG CVSTVQCPSF
     SHYSVCTSSC PDTCSDLTAS RNCATPCTEG CECNQGFVLS TSQCVPLHKC GCDFDGHYYT
     MGEFFWATAN CTVQCLCEEG GDVYCFNKTC GSGEVCAVED GYQGCFPKRE TVCLLSQNQV
     LHTFDGASYA FPSEFSYTLL KTCPERPEYL EIDINKKKPD AGPAWLRGLR ILVADQEVKI
     GGIGASEVKL NGQEVELPFF HPSGKLEIYR NKNSTTVESK GVVTVQYSDI GLLYIRLSTT
     YFNCTGGLCG FYNANASDEF CLPNGKCTDN LAVFLESWTT FEEICNGECG DLLKACNNDS
     ELLKFYRSRS RCGIINDPSN SSFLECHGVV NVTAYYRTCL FRLCQSGGNE SELCDSVARY
     ASACKNADVE VGPWRTYDFC PLECPENSHF EECITCTETC ETLTLGPICV DSCSEGCQCD
     EGYALLGSQC VTRSECGCNF EGHQLATNET FWVDLDCQIF CYCSGTDNRV HCETIPCKDD
     EYCMEEGGLY YCQARTDASC IVSGYGHYLT FDGFPFDFQT SCPLILCTTG SRPSSDSFPK
     FVVTAKNEDR DPSLALWVKQ VDVTVFGYSI VIHRAYKHTV LVNSERLYLP LKLGQGKINI
     FSFGFHVVVE TDFGLKVVYD WKTFLSITVP RSMQNSTYGL CGRYNGNPDD DLEMPMGLLA
     SSVNEFGQSW VKRDTFCQVG CGDRCPSCAK VEGFSKVQQL CSLIPNQNAA FSKCHSKVNP
     TFFYKNCLFD SCIDGGAVQT ACSWLQNYAS TCQTQGITVT GWRNYTSCTV TCPPNSHYES
     CVSVCQPRCA AIRLKSDCSH YCVEGCHCDA GYVLNGKSCI LPHSCGCYSD GKYYEPKQLF
     WNSDCTRRCR CFRRNVIQCD PRQCKSDEEC ALRNGVRGCF STKTSYCLAA GGGVFRTFDG
     AFLRFPANCA FVLSTICQKL PDISFQLIIN FDKWSAPNLT IISPVYFYIN EEQILINDRN
     TVKVNGTQVN VPFITGLATK IYSSEGFLVI DTSPDIQIYY NGFNVIKISI SERLQNKVCG
     LCGNFNGDLT DDYVTLRGKP VVSSVVLAQS WKTNGMQKRP LAPSCNELQF SQYAAMCDNV
     HIQKMQGDGY CLKLTDMKGF FQPCYGLLDP LPFYESCYLD GCYSHKKFQL CGSLAAYGEA
     CRSFGILSTE WIEKENCSGV VEDPCVGADC PNRTCELGNG RELCGCIEPP PYGNNSHDII
     DAEVTCKAAQ MEVSISKCKL FQLGFEREGV RINDRQCTGI EGEDFISFQI NNTKGNCGNI
     VQSNGTHIMY KNTLWIESAN NTGNIITRDR TINVEFSCAY ELDIKISLDS VVKPMLSVIN
     LTVPTQEGSF ITKMALYKNA SYKHPYRQGE VVLTTRDVLY VGVFVVGADA THLILTLNKC
     YATPTRDSND KLRYFIIEGG CQNLKDNTIG IEENAVSLTC RFHVTVFKFI GDYDEVHLHC
     AVSLCDSEKY SCKITCPHNS RIATDYTKEP KEQIISVGPI RRKRLDWCED NGGCEQICTS
     RVDGPLCSCV TGTLQEDGKS CRASNSSMEL QVWTLLLIMI QISLWHFVYK SGTTS
//