{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O75417","secondaryAccessions":["O95160","Q6VMB5"],"uniProtkbId":"DPOLQ_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-03-08","entryVersion":179,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10395804"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14576298"}],"value":"DNA polymerase theta"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"value":"DNA polymerase eta"}}],"includes":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Helicase POLQ"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29444826"}],"value":"5.6.2.4"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"DNA polymerase POLQ"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14576298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18503084"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22135286"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27591252"}],"value":"2.7.7.7"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"RNA-directed DNA polymerase POLQ"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34117057"}],"value":"2.7.7.49"}]}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10395804"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14576298"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:9186"}],"value":"POLQ"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"value":"POLH"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CGS6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14576298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18503084"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19188258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21050863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22135286"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24648516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25642963"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25643323"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26636256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311885"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27591252"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28695890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29444826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30655289"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31562312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32234782"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32873648"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34117057"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34140467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34179826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36455556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37440612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}],"value":"Low-fidelity DNA polymerase with a putative helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34140467, PubMed:34179826, PubMed:36455556, PubMed:37440612, PubMed:37674080). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37440612, PubMed:37674080). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Promotes dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890). DNA helicase activity has been examined and has (PubMed:29444826) and has not (PubMed:14576298, PubMed:36455556) been demonstrated (PubMed:14576298, PubMed:29444826, PubMed:36455556)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22508"},{"database":"Rhea","id":"RHEA-COMP:17339"},{"database":"Rhea","id":"RHEA-COMP:17340"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61560"},{"database":"ChEBI","id":"CHEBI:173112"}],"ecNumber":"2.7.7.7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14576298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18503084"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22135286"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311885"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27591252"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22508"},{"database":"Rhea","id":"RHEA-COMP:17339"},{"database":"Rhea","id":"RHEA-COMP:17340"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61560"},{"database":"ChEBI","id":"CHEBI:173112"}],"ecNumber":"2.7.7.49","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34117057"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14576298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25642963"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31562312"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.","ecNumber":"5.6.2.4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29444826"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"5.6.2.4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29444826"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311885"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34140467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34179826"}],"value":"Specifically inhibited by the antibiotic novobiocin (PubMed:34179826). The polymerase activity is specifically inhibited by the small molecule ART558 (PubMed:34140467). Novobiocin and ART558 confer specific killing of BRCA1/2-deficient cells and synergize with the poly [ADP-ribose] polymerase (PARP) inhibitor olaparib (PubMed:34140467, PubMed:34179826)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":1.095,"unit":"uM","substrate":"dATP:T","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22135286"}]},{"constant":0.622,"unit":"uM","substrate":"dATP: abasic site","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22135286"}]},{"constant":3.08,"unit":"uM","substrate":"dGTP: no template","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22135286"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24989122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25642963"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25643323"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26636256"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31562312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37440612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}],"value":"Homomultimer; forms homodimers and homotetramers (PubMed:25643323, PubMed:26636256, PubMed:31562312). Interacts with RAD51 (PubMed:25642963). Interacts with ORC2 and ORC4 (PubMed:24989122). Interacts with RHNO1; interaction takes place during mitosis and promotes POLQ recruitment to DNA damage sites (PubMed:37440612). Interacts (when phosphorylated) with TOPBP1 (via BRCT domains 7 and 8); promoting POLQ recruitment to DNA damage sites (PubMed:37674080)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O75417","intActId":"EBI-11062063"},"interactantTwo":{"uniProtKBAccession":"P49756","geneName":"RBM25","intActId":"EBI-2211856"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75417-1","intActId":"EBI-16141065"},"interactantTwo":{"uniProtKBAccession":"O75417-1","geneName":"POLQ","intActId":"EBI-16141065"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75417-1","intActId":"EBI-16141065"},"interactantTwo":{"uniProtKBAccession":"Q06609","geneName":"RAD51","intActId":"EBI-297202"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24989122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25642963"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34179826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37440612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}],"value":"Enriched in chromatin in response to ultaviolet (UV) light (PubMed:25642963, PubMed:34179826). Binds to chromatin during early G1 (PubMed:24989122). Recruited to DNA damage sites, such as double-stranded breaks (DSBs), following interaction with TOPBP1 and RHNO1 (PubMed:37440612, PubMed:37674080)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O18475"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25642963"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34179826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37440612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["O75417-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["O75417-2"],"sequenceIds":["VSP_040747","VSP_040748"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14576298"}],"value":"Highly expressed in testis"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29444826"}],"value":"The N-terminal helicase-like domain (residues 1-894) unwinds DNA with 3'-5' polarity on substrates with 3' and 5' overhangs, blunt ends and replication forks. It also unwinds RNA:DNA hybrids with a 3' DNA overhang; it does not translocate on RNA and does not unwind RNA:RNA hybrids"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25643323"}],"value":"The loop 2 region is involved in the binding of the 2 ends of resected double-strand breaks and homomultimerization"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}],"value":"Phosphorylated by PLK1; promoting interaction with TOPBP1 and recruitment to DNA damage sites"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Breast cancer","diseaseAccession":"DI-02602","acronym":"BC","description":"A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.","diseaseCrossReference":{"database":"MIM","id":"114480"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20624954"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20700469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25409685"}]},"note":{"texts":[{"value":"The gene represented in this entry may be involved in disease pathogenesis"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the DNA polymerase type-A family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38640889"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33577776"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"38640897"}],"value":"A publication reported some endonuclease activity required to trim the 3' ends before synthesis can occur. However, subsequent research from the same group showed that DNA synthesis products generated by POLQ that migrate more quickly on denaturing polyacrylamide gels arise by production of stable stem-loop structures rather than from nuclease activity (PubMed:38640889). The original publication was therefore retracted"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Was wrongly named DNA polymerase eta (POLH) by some authors (Ref.4). This protein corresponds to DNA polymerase theta (POLQ) and should not be confused with DNA polymerase eta (POLH) (AC Q9Y253)"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAD05272.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2590,"modifier":"EXACT"}},"description":"DNA polymerase theta","featureId":"PRO_0000101279"},{"type":"Domain","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"Helicase ATP-binding","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00541"}]},{"type":"Domain","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":554,"modifier":"EXACT"}},"description":"Helicase C-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00542"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":554,"modifier":"EXACT"}},"description":"Helicase activity","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":847,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Interaction with RAD51","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25642963"}]},{"type":"Region","location":{"start":{"value":1034,"modifier":"EXACT"},"end":{"value":1060,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1594,"modifier":"EXACT"},"end":{"value":1622,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1777,"modifier":"EXACT"},"end":{"value":1797,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2097,"modifier":"EXACT"},"end":{"value":2584,"modifier":"EXACT"}},"description":"DNA polymerase activity","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":2142,"modifier":"EXACT"},"end":{"value":2177,"modifier":"EXACT"}},"description":"Loop 1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21050863"}]},{"type":"Region","location":{"start":{"value":2257,"modifier":"EXACT"},"end":{"value":2322,"modifier":"EXACT"}},"description":"Loop 2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21050863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25643323"}]},{"type":"Region","location":{"start":{"value":2491,"modifier":"EXACT"},"end":{"value":2535,"modifier":"EXACT"}},"description":"Loop 3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21050863"}]},{"type":"Motif","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"DEAH box"},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1040,"modifier":"EXACT"},"end":{"value":1050,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1598,"modifier":"EXACT"},"end":{"value":1619,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26636256"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5A9F"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5AGA"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00541"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26636256"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5A9F"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5AGA"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":2330,"modifier":"EXACT"},"end":{"value":2330,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X0Q"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":2331,"modifier":"EXACT"},"end":{"value":2331,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X0Q"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":2540,"modifier":"EXACT"},"end":{"value":2540,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X0Q"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Modified residue","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1289,"modifier":"EXACT"},"end":{"value":1289,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Modified residue","location":{"start":{"value":1482,"modifier":"EXACT"},"end":{"value":1482,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Modified residue","location":{"start":{"value":1486,"modifier":"EXACT"},"end":{"value":1486,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Modified residue","location":{"start":{"value":1488,"modifier":"EXACT"},"end":{"value":1488,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Modified residue","location":{"start":{"value":1493,"modifier":"EXACT"},"end":{"value":1493,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Modified residue","location":{"start":{"value":1555,"modifier":"EXACT"},"end":{"value":1555,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Modified residue","location":{"start":{"value":1563,"modifier":"EXACT"},"end":{"value":1563,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Modified residue","location":{"start":{"value":1628,"modifier":"EXACT"},"end":{"value":1628,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Modified residue","location":{"start":{"value":1635,"modifier":"EXACT"},"end":{"value":1635,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Modified residue","location":{"start":{"value":1755,"modifier":"EXACT"},"end":{"value":1755,"modifier":"EXACT"}},"description":"Phosphothreonine; by PLK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":828,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10395804"}],"featureId":"VSP_040747","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":829,"modifier":"EXACT"},"end":{"value":840,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10395804"}],"featureId":"VSP_040748","alternativeSequence":{"originalSequence":"VEVILKNAVPFK","alternativeSequences":["MNSFLSFPISLC"]}},{"type":"Natural variant","location":{"start":{"value":1056,"modifier":"EXACT"},"end":{"value":1056,"modifier":"EXACT"}},"description":"in dbSNP:rs34778629","featureCrossReferences":[{"database":"dbSNP","id":"rs34778629"}],"featureId":"VAR_055707","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Loss of DNA helicase activity. Abolished ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29444826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31562312"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["M"]}},{"type":"Mutagenesis","location":{"start":{"value":1482,"modifier":"EXACT"},"end":{"value":1493,"modifier":"EXACT"}},"description":"In 4S-P mutant; decreased phosphorylation by PLK1, leading to impaired interaction with TOPBP1 and recruitment to DNA damage sites.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}],"alternativeSequence":{"originalSequence":"SLNMSDSLLFDS","alternativeSequences":["ALNMADALLFDA"]}},{"type":"Mutagenesis","location":{"start":{"value":1977,"modifier":"EXACT"},"end":{"value":1977,"modifier":"EXACT"}},"description":"Decreased protein stability.","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25775267"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Mutagenesis","location":{"start":{"value":2181,"modifier":"EXACT"},"end":{"value":2181,"modifier":"EXACT"}},"description":"Impaired ability to bypass abasic sites.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":2202,"modifier":"EXACT"},"end":{"value":2202,"modifier":"EXACT"}},"description":"Impaired ability to bypass abasic sites. In Pol-theta(RR) mutant; abolished polymerase activity; when associated with V-2254.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311885"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":2254,"modifier":"EXACT"},"end":{"value":2254,"modifier":"EXACT"}},"description":"Impaired ability to bypass abasic sites.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A","V"]}},{"type":"Mutagenesis","location":{"start":{"value":2254,"modifier":"EXACT"},"end":{"value":2254,"modifier":"EXACT"}},"description":"In Pol-theta(RR) mutant; abolished polymerase activity; when associated with A-2202.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311885"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":2540,"modifier":"EXACT"},"end":{"value":2541,"modifier":"EXACT"}},"description":"Abolishes DNA polymerase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19188258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24648516"}],"alternativeSequence":{"originalSequence":"DE","alternativeSequences":["AA"]}},{"type":"Sequence conflict","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"in Ref. 2; AAR08421","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":982,"modifier":"EXACT"},"end":{"value":982,"modifier":"EXACT"}},"description":"in Ref. 2; AAR08421","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":2013,"modifier":"EXACT"},"end":{"value":2013,"modifier":"EXACT"}},"description":"in Ref. 4; AAD05272","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":2513,"modifier":"EXACT"},"end":{"value":2513,"modifier":"EXACT"}},"description":"in Ref. 1; AAC33565 and 2; AAR08421","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":2547,"modifier":"EXACT"},"end":{"value":2547,"modifier":"EXACT"}},"description":"in Ref. 1; AAC33565","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Helix","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Turn","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5Q"}]},{"type":"Helix","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8W0A"}]},{"type":"Helix","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Turn","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5Q"}]},{"type":"Beta strand","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8W0A"}]},{"type":"Helix","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5Q"}]},{"type":"Helix","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BH9"}]},{"type":"Beta strand","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":464,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":479,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BHA"}]},{"type":"Turn","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":490,"modifier":"EXACT"},"end":{"value":496,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Turn","location":{"start":{"value":498,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5Q"}]},{"type":"Helix","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":512,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5Q"}]},{"type":"Helix","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":556,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Turn","location":{"start":{"value":559,"modifier":"EXACT"},"end":{"value":562,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":581,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":594,"modifier":"EXACT"},"end":{"value":598,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":611,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":638,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":640,"modifier":"EXACT"},"end":{"value":643,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8W0A"}]},{"type":"Beta strand","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":648,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":658,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BH6"}]},{"type":"Beta strand","location":{"start":{"value":659,"modifier":"EXACT"},"end":{"value":662,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5Q"}]},{"type":"Helix","location":{"start":{"value":663,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ASJ"}]},{"type":"Helix","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":674,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":678,"modifier":"EXACT"},"end":{"value":687,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":691,"modifier":"EXACT"},"end":{"value":698,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Turn","location":{"start":{"value":708,"modifier":"EXACT"},"end":{"value":711,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":712,"modifier":"EXACT"},"end":{"value":728,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Turn","location":{"start":{"value":729,"modifier":"EXACT"},"end":{"value":731,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":734,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":745,"modifier":"EXACT"},"end":{"value":768,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":772,"modifier":"EXACT"},"end":{"value":778,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":781,"modifier":"EXACT"},"end":{"value":787,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":794,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":796,"modifier":"EXACT"},"end":{"value":798,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":799,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BH9"}]},{"type":"Helix","location":{"start":{"value":804,"modifier":"EXACT"},"end":{"value":811,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Turn","location":{"start":{"value":812,"modifier":"EXACT"},"end":{"value":814,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":818,"modifier":"EXACT"},"end":{"value":822,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":826,"modifier":"EXACT"},"end":{"value":834,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":835,"modifier":"EXACT"},"end":{"value":837,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5Q"}]},{"type":"Beta strand","location":{"start":{"value":840,"modifier":"EXACT"},"end":{"value":842,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":850,"modifier":"EXACT"},"end":{"value":857,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5Q"}]},{"type":"Beta strand","location":{"start":{"value":858,"modifier":"EXACT"},"end":{"value":861,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9C5Q"}]},{"type":"Beta strand","location":{"start":{"value":862,"modifier":"EXACT"},"end":{"value":864,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BP9"}]},{"type":"Helix","location":{"start":{"value":867,"modifier":"EXACT"},"end":{"value":869,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Helix","location":{"start":{"value":872,"modifier":"EXACT"},"end":{"value":889,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5AGA"}]},{"type":"Beta strand","location":{"start":{"value":1826,"modifier":"EXACT"},"end":{"value":1829,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":1830,"modifier":"EXACT"},"end":{"value":1832,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":1834,"modifier":"EXACT"},"end":{"value":1845,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":1848,"modifier":"EXACT"},"end":{"value":1858,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Turn","location":{"start":{"value":1862,"modifier":"EXACT"},"end":{"value":1864,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8E24"}]},{"type":"Helix","location":{"start":{"value":1865,"modifier":"EXACT"},"end":{"value":1867,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8E24"}]},{"type":"Beta strand","location":{"start":{"value":1889,"modifier":"EXACT"},"end":{"value":1892,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":1895,"modifier":"EXACT"},"end":{"value":1908,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":1911,"modifier":"EXACT"},"end":{"value":1916,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Turn","location":{"start":{"value":1928,"modifier":"EXACT"},"end":{"value":1930,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":1941,"modifier":"EXACT"},"end":{"value":1952,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":1961,"modifier":"EXACT"},"end":{"value":1963,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":1967,"modifier":"EXACT"},"end":{"value":1978,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":1983,"modifier":"EXACT"},"end":{"value":1987,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":1989,"modifier":"EXACT"},"end":{"value":1996,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2001,"modifier":"EXACT"},"end":{"value":2003,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8E24"}]},{"type":"Helix","location":{"start":{"value":2005,"modifier":"EXACT"},"end":{"value":2012,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2014,"modifier":"EXACT"},"end":{"value":2020,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Turn","location":{"start":{"value":2021,"modifier":"EXACT"},"end":{"value":2023,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6XBU"}]},{"type":"Helix","location":{"start":{"value":2024,"modifier":"EXACT"},"end":{"value":2027,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2028,"modifier":"EXACT"},"end":{"value":2030,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Turn","location":{"start":{"value":2032,"modifier":"EXACT"},"end":{"value":2034,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2037,"modifier":"EXACT"},"end":{"value":2040,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2042,"modifier":"EXACT"},"end":{"value":2067,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2069,"modifier":"EXACT"},"end":{"value":2072,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6XBU"}]},{"type":"Helix","location":{"start":{"value":2073,"modifier":"EXACT"},"end":{"value":2077,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2078,"modifier":"EXACT"},"end":{"value":2090,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2092,"modifier":"EXACT"},"end":{"value":2094,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2096,"modifier":"EXACT"},"end":{"value":2121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2130,"modifier":"EXACT"},"end":{"value":2134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2135,"modifier":"EXACT"},"end":{"value":2140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2143,"modifier":"EXACT"},"end":{"value":2146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8E23"}]},{"type":"Helix","location":{"start":{"value":2181,"modifier":"EXACT"},"end":{"value":2187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Turn","location":{"start":{"value":2188,"modifier":"EXACT"},"end":{"value":2190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2192,"modifier":"EXACT"},"end":{"value":2206,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2207,"modifier":"EXACT"},"end":{"value":2211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2212,"modifier":"EXACT"},"end":{"value":2217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2219,"modifier":"EXACT"},"end":{"value":2221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Turn","location":{"start":{"value":2222,"modifier":"EXACT"},"end":{"value":2225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2226,"modifier":"EXACT"},"end":{"value":2229,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2232,"modifier":"EXACT"},"end":{"value":2234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2238,"modifier":"EXACT"},"end":{"value":2240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2243,"modifier":"EXACT"},"end":{"value":2247,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2249,"modifier":"EXACT"},"end":{"value":2251,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2252,"modifier":"EXACT"},"end":{"value":2255,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2256,"modifier":"EXACT"},"end":{"value":2260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2303,"modifier":"EXACT"},"end":{"value":2306,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8GD7"}]},{"type":"Beta strand","location":{"start":{"value":2308,"modifier":"EXACT"},"end":{"value":2312,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2314,"modifier":"EXACT"},"end":{"value":2317,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2325,"modifier":"EXACT"},"end":{"value":2331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2334,"modifier":"EXACT"},"end":{"value":2343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2346,"modifier":"EXACT"},"end":{"value":2354,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2358,"modifier":"EXACT"},"end":{"value":2367,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2371,"modifier":"EXACT"},"end":{"value":2373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2376,"modifier":"EXACT"},"end":{"value":2390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2395,"modifier":"EXACT"},"end":{"value":2402,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2406,"modifier":"EXACT"},"end":{"value":2419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2421,"modifier":"EXACT"},"end":{"value":2437,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2438,"modifier":"EXACT"},"end":{"value":2441,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2443,"modifier":"EXACT"},"end":{"value":2445,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9AU5"}]},{"type":"Beta strand","location":{"start":{"value":2447,"modifier":"EXACT"},"end":{"value":2449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2451,"modifier":"EXACT"},"end":{"value":2453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2458,"modifier":"EXACT"},"end":{"value":2494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2502,"modifier":"EXACT"},"end":{"value":2506,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2527,"modifier":"EXACT"},"end":{"value":2529,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8E24"}]},{"type":"Beta strand","location":{"start":{"value":2531,"modifier":"EXACT"},"end":{"value":2537,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2539,"modifier":"EXACT"},"end":{"value":2546,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2548,"modifier":"EXACT"},"end":{"value":2550,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2551,"modifier":"EXACT"},"end":{"value":2563,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Beta strand","location":{"start":{"value":2564,"modifier":"EXACT"},"end":{"value":2566,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9AU5"}]},{"type":"Helix","location":{"start":{"value":2571,"modifier":"EXACT"},"end":{"value":2573,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8E24"}]},{"type":"Beta strand","location":{"start":{"value":2574,"modifier":"EXACT"},"end":{"value":2581,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZUS"}]},{"type":"Helix","location":{"start":{"value":2582,"modifier":"EXACT"},"end":{"value":2584,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZX1"}]},{"type":"Beta strand","location":{"start":{"value":2586,"modifier":"EXACT"},"end":{"value":2588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8E24"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"id":"KW-0239","category":"Molecular function","name":"DNA-directed DNA polymerase"},{"id":"KW-0347","category":"Molecular function","name":"Helicase"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"10395804","citationType":"journal article","authors":["Sharief F.S.","Vojta P.J.","Ropp P.A.","Copeland W.C."],"citationCrossReferences":[{"database":"PubMed","id":"10395804"},{"database":"DOI","id":"10.1006/geno.1999.5843"}],"title":"Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase.","publicationDate":"1999","journal":"Genomics","firstPage":"90","lastPage":"96","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Spleen","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14576298","citationType":"journal article","authors":["Seki M.","Marini F.","Wood R.D."],"citationCrossReferences":[{"database":"PubMed","id":"14576298"},{"database":"DOI","id":"10.1093/nar/gkg814"}],"title":"POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.","publicationDate":"2003","journal":"Nucleic Acids Res.","firstPage":"6117","lastPage":"6126","volume":"31"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION AS AN ATPASE","NO HELICASE ACTIVITY","TISSUE SPECIFICITY","CATALYTIC ACTIVITY"]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.-S.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-A9BI7TQ6LCOSD","citationType":"submission","authors":["Harris P.V.","Kaelin C.B.","Burtis K.C."],"title":"Catalytic activity of Pol eta, a new human DNA polymerase related to the bacterial DNA polymerase I family and Drosophila Mus308.","publicationDate":"JAN-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1435-2590"]},{"referenceNumber":5,"citation":{"id":"18503084","citationType":"journal article","authors":["Arana M.E.","Seki M.","Wood R.D.","Rogozin I.B.","Kunkel T.A."],"citationCrossReferences":[{"database":"PubMed","id":"18503084"},{"database":"DOI","id":"10.1093/nar/gkn310"}],"title":"Low-fidelity DNA synthesis by human DNA polymerase theta.","publicationDate":"2008","journal":"Nucleic Acids Res.","firstPage":"3847","lastPage":"3856","volume":"36"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":6,"citation":{"id":"19188258","citationType":"journal article","authors":["Prasad R.","Longley M.J.","Sharief F.S.","Hou E.W.","Copeland W.C.","Wilson S.H."],"citationCrossReferences":[{"database":"PubMed","id":"19188258"},{"database":"DOI","id":"10.1093/nar/gkp035"}],"title":"Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro.","publicationDate":"2009","journal":"Nucleic Acids Res.","firstPage":"1868","lastPage":"1877","volume":"37"},"referencePositions":["FUNCTION","MUTAGENESIS OF 2540-ASP-GLU-2541"]},{"referenceNumber":7,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-990","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"20700469","citationType":"journal article","authors":["Higgins G.S.","Harris A.L.","Prevo R.","Helleday T.","McKenna W.G.","Buffa F.M."],"citationCrossReferences":[{"database":"PubMed","id":"20700469"},{"database":"DOI","id":"10.18632/oncotarget.124"}],"title":"Overexpression of POLQ confers a poor prognosis in early breast cancer patients.","publicationDate":"2010","journal":"Oncotarget","firstPage":"175","lastPage":"184","volume":"1"},"referencePositions":["INVOLVEMENT IN BC"]},{"referenceNumber":9,"citation":{"id":"20624954","citationType":"journal article","authors":["Lemee F.","Bergoglio V.","Fernandez-Vidal A.","Machado-Silva A.","Pillaire M.J.","Bieth A.","Gentil C.","Baker L.","Martin A.L.","Leduc C.","Lam E.","Magdeleine E.","Filleron T.","Oumouhou N.","Kaina B.","Seki M.","Grimal F.","Lacroix-Triki M.","Thompson A.","Roche H.","Bourdon J.C.","Wood R.D.","Hoffmann J.S.","Cazaux C."],"citationCrossReferences":[{"database":"PubMed","id":"20624954"},{"database":"DOI","id":"10.1073/pnas.0910759107"}],"title":"DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"13390","lastPage":"13395","volume":"107"},"referencePositions":["INVOLVEMENT IN BC"]},{"referenceNumber":10,"citation":{"id":"21050863","citationType":"journal article","authors":["Hogg M.","Seki M.","Wood R.D.","Doublie S.","Wallace S.S."],"citationCrossReferences":[{"database":"PubMed","id":"21050863"},{"database":"DOI","id":"10.1016/j.jmb.2010.10.041"}],"title":"Lesion bypass activity of DNA polymerase theta (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.","publicationDate":"2011","journal":"J. Mol. Biol.","firstPage":"642","lastPage":"652","volume":"405"},"referencePositions":["FUNCTION"]},{"referenceNumber":11,"citation":{"id":"22135286","citationType":"journal article","authors":["Hogg M.","Sauer-Eriksson A.E.","Johansson E."],"citationCrossReferences":[{"database":"PubMed","id":"22135286"},{"database":"DOI","id":"10.1093/nar/gkr1102"}],"title":"Promiscuous DNA synthesis by human DNA polymerase theta.","publicationDate":"2012","journal":"Nucleic Acids Res.","firstPage":"2611","lastPage":"2622","volume":"40"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","BIOPHYSICOCHEMICAL PROPERTIES"]},{"referenceNumber":12,"citation":{"id":"25409685","citationType":"journal article","authors":["Brandalize A.P.","Schueler-Faccini L.","Hoffmann J.S.","Caleffi M.","Cazaux C.","Ashton-Prolla P."],"citationCrossReferences":[{"database":"PubMed","id":"25409685"},{"database":"DOI","id":"10.1186/1471-2407-14-850"}],"title":"A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.","publicationDate":"2014","journal":"BMC Cancer","firstPage":"850","lastPage":"850","volume":"14"},"referencePositions":["INVOLVEMENT IN BC"]},{"referenceNumber":13,"citation":{"id":"24648516","citationType":"journal article","authors":["Yoon J.H.","Roy Choudhury J.","Park J.","Prakash S.","Prakash L."],"citationCrossReferences":[{"database":"PubMed","id":"24648516"},{"database":"DOI","id":"10.1074/jbc.m114.556977"}],"title":"A role for DNA polymerase theta in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"13177","lastPage":"13185","volume":"289"},"referencePositions":["FUNCTION","MUTAGENESIS OF 2540-ASP-GLU-2541"]},{"referenceNumber":14,"citation":{"id":"24989122","citationType":"journal article","authors":["Fernandez-Vidal A.","Guitton-Sert L.","Cadoret J.C.","Drac M.","Schwob E.","Baldacci G.","Cazaux C.","Hoffmann J.S."],"citationCrossReferences":[{"database":"PubMed","id":"24989122"},{"database":"DOI","id":"10.1038/ncomms5285"}],"title":"A role for DNA polymerase theta in the timing of DNA replication.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4285","lastPage":"4285","volume":"5"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH ORC2 AND ORC4"]},{"referenceNumber":15,"citation":{"id":"25642963","citationType":"journal article","authors":["Ceccaldi R.","Liu J.C.","Amunugama R.","Hajdu I.","Primack B.","Petalcorin M.I.","O'Connor K.W.","Konstantinopoulos P.A.","Elledge S.J.","Boulton S.J.","Yusufzai T.","D'Andrea A.D."],"citationCrossReferences":[{"database":"PubMed","id":"25642963"},{"database":"DOI","id":"10.1038/nature14184"}],"title":"Homologous-recombination-deficient tumours are dependent on Poltheta-mediated repair.","publicationDate":"2015","journal":"Nature","firstPage":"258","lastPage":"262","volume":"518"},"referencePositions":["FUNCTION","ATPASE ACTIVITY","INTERACTION WITH RAD51","SUBCELLULAR LOCATION"]},{"referenceNumber":16,"citation":{"id":"25643323","citationType":"journal article","authors":["Kent T.","Chandramouly G.","McDevitt S.M.","Ozdemir A.Y.","Pomerantz R.T."],"citationCrossReferences":[{"database":"PubMed","id":"25643323"},{"database":"DOI","id":"10.1038/nsmb.2961"}],"title":"Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase theta.","publicationDate":"2015","journal":"Nat. Struct. Mol. Biol.","firstPage":"230","lastPage":"237","volume":"22"},"referencePositions":["FUNCTION","SUBUNIT","DOMAIN"]},{"referenceNumber":17,"citation":{"id":"27311885","citationType":"journal article","authors":["Kent T.","Mateos-Gomez P.A.","Sfeir A.","Pomerantz R.T."],"citationCrossReferences":[{"database":"PubMed","id":"27311885"},{"database":"DOI","id":"10.7554/elife.13740"}],"title":"Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining.","publicationDate":"2016","journal":"Elife","firstPage":"0","lastPage":"0","volume":"5"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","COFACTOR","MUTAGENESIS OF ARG-2202 AND ARG-2254"]},{"referenceNumber":18,"citation":{"id":"27591252","citationType":"journal article","authors":["Kent T.","Rusanov T.D.","Hoang T.M.","Velema W.A.","Krueger A.T.","Copeland W.C.","Kool E.T.","Pomerantz R.T."],"citationCrossReferences":[{"database":"PubMed","id":"27591252"},{"database":"DOI","id":"10.1093/nar/gkw721"}],"title":"DNA polymerase theta specializes in incorporating synthetic expanded-size (xDNA) nucleotides.","publicationDate":"2016","journal":"Nucleic Acids Res.","firstPage":"9381","lastPage":"9392","volume":"44"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":19,"citation":{"id":"28695890","citationType":"journal article","authors":["Saito S.","Maeda R.","Adachi N."],"citationCrossReferences":[{"database":"PubMed","id":"28695890"},{"database":"DOI","id":"10.1038/ncomms16112"}],"title":"Dual loss of human POLQ and LIG4 abolishes random integration.","publicationDate":"2017","journal":"Nat. Commun.","firstPage":"16112","lastPage":"16112","volume":"8"},"referencePositions":["FUNCTION"]},{"referenceNumber":20,"citation":{"id":"29444826","citationType":"journal article","authors":["Ozdemir A.Y.","Rusanov T.","Kent T.","Siddique L.A.","Pomerantz R.T."],"citationCrossReferences":[{"database":"PubMed","id":"29444826"},{"database":"DOI","id":"10.1074/jbc.ra117.000565"}],"title":"Polymerase theta-helicase efficiently unwinds DNA and RNA-DNA hybrids.","publicationDate":"2018","journal":"J. Biol. Chem.","firstPage":"5259","lastPage":"5269","volume":"293"},"referencePositions":["FUNCTION AS A 3'-5' DNA HELICASE","DOMAIN","MUTAGENESIS OF LYS-121"]},{"referenceNumber":21,"citation":{"id":"30655289","citationType":"journal article","authors":["Wang Z.","Song Y.","Li S.","Kurian S.","Xiang R.","Chiba T.","Wu X."],"citationCrossReferences":[{"database":"PubMed","id":"30655289"},{"database":"DOI","id":"10.1074/jbc.ra118.005188"}],"title":"DNA polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.","publicationDate":"2019","journal":"J. Biol. Chem.","firstPage":"3909","lastPage":"3919","volume":"294"},"referencePositions":["FUNCTION"]},{"referenceNumber":22,"citation":{"id":"31562312","citationType":"journal article","authors":["Black S.J.","Ozdemir A.Y.","Kashkina E.","Kent T.","Rusanov T.","Ristic D.","Shin Y.","Suma A.","Hoang T.","Chandramouly G.","Siddique L.A.","Borisonnik N.","Sullivan-Reed K.","Mallon J.S.","Skorski T.","Carnevale V.","Murakami K.S.","Wyman C.","Pomerantz R.T."],"citationCrossReferences":[{"database":"PubMed","id":"31562312"},{"database":"DOI","id":"10.1038/s41467-019-12272-9"}],"title":"Molecular basis of microhomology-mediated end-joining by purified full-length Poltheta.","publicationDate":"2019","journal":"Nat. Commun.","firstPage":"4423","lastPage":"4423","volume":"10"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","SUBUNIT","MUTAGENESIS OF LYS-121"]},{"referenceNumber":23,"citation":{"id":"32273507","citationType":"journal article","authors":["Black S.J.","Ozdemir A.Y.","Kashkina E.","Kent T.","Rusanov T.","Ristic D.","Shin Y.","Suma A.","Hoang T.","Chandramouly G.","Siddique L.A.","Borisonnik N.","Sullivan-Reed K.","Mallon J.S.","Skorski T.","Carnevale V.","Murakami K.S.","Wyman C.","Pomerantz R.T."],"citationCrossReferences":[{"database":"PubMed","id":"32273507"},{"database":"DOI","id":"10.1038/s41467-020-15551-y"}],"publicationDate":"2020","journal":"Nat. Commun.","firstPage":"1831","lastPage":"1831","volume":"11"},"referencePositions":["ERRATUM OF PUBMED:31562312"]},{"referenceNumber":24,"citation":{"id":"32234782","citationType":"journal article","authors":["Carvajal-Garcia J.","Cho J.E.","Carvajal-Garcia P.","Feng W.","Wood R.D.","Sekelsky J.","Gupta G.P.","Roberts S.A.","Ramsden D.A."],"citationCrossReferences":[{"database":"PubMed","id":"32234782"},{"database":"DOI","id":"10.1073/pnas.1921791117"}],"title":"Mechanistic basis for microhomology identification and genome scarring by polymerase theta.","publicationDate":"2020","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"8476","lastPage":"8485","volume":"117"},"referencePositions":["FUNCTION"]},{"referenceNumber":25,"citation":{"id":"32873648","citationType":"journal article","authors":["Davis L.","Khoo K.J.","Zhang Y.","Maizels N."],"citationCrossReferences":[{"database":"PubMed","id":"32873648"},{"database":"DOI","id":"10.1073/pnas.2008073117"}],"title":"POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks.","publicationDate":"2020","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"22900","lastPage":"22909","volume":"117"},"referencePositions":["FUNCTION"]},{"referenceNumber":26,"citation":{"id":"33577776","citationType":"journal article","authors":["Zahn K.E.","Jensen R.B.","Wood R.D.","Doublie S."],"citationCrossReferences":[{"database":"PubMed","id":"33577776"},{"database":"DOI","id":"10.1016/j.molcel.2021.01.021"}],"title":"Human DNA polymerase theta harbors DNA end-trimming activity critical for DNA repair.","publicationDate":"2021","journal":"Mol. Cell","firstPage":"1534","lastPage":"1547","volume":"81"},"referencePositions":["RETRACTED PAPER"]},{"referenceNumber":27,"citation":{"id":"38640897","citationType":"journal article","authors":["Zahn K.E.","Jensen R.B.","Wood R.D.","Doublie S."],"citationCrossReferences":[{"database":"PubMed","id":"38640897"},{"database":"DOI","id":"10.1016/j.molcel.2024.03.024"}],"title":"Retraction Notice to: Human DNA polymerase theta harbors DNA end-trimming activity critical for DNA repair.","publicationDate":"2024","journal":"Mol. Cell","firstPage":"1626","lastPage":"1626","volume":"84"},"referencePositions":["RETRACTION NOTICE OF PUBMED:33577776"]},{"referenceNumber":28,"citation":{"id":"34179826","citationType":"journal article","authors":["Zhou J.","Gelot C.","Pantelidou C.","Li A.","Yuecel H.","Davis R.E.","Faerkkilae A.","Kochupurakkal B.","Syed A.","Shapiro G.I.","Tainer J.A.","Blagg B.S.J.","Ceccaldi R.","D'Andrea A.D."],"citationCrossReferences":[{"database":"PubMed","id":"34179826"},{"database":"DOI","id":"10.1038/s43018-021-00203-x"}],"title":"A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.","publicationDate":"2021","journal":"Nat. Cancer","firstPage":"598","lastPage":"610","volume":"2"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","SUBCELLULAR LOCATION"]},{"referenceNumber":29,"citation":{"id":"34140467","citationType":"journal article","authors":["Zatreanu D.","Robinson H.M.R.","Alkhatib O.","Boursier M.","Finch H.","Geo L.","Grande D.","Grinkevich V.","Heald R.A.","Langdon S.","Majithiya J.","McWhirter C.","Martin N.M.B.","Moore S.","Neves J.","Rajendra E.","Ranzani M.","Schaedler T.","Stockley M.","Wiggins K.","Brough R.","Sridhar S.","Gulati A.","Shao N.","Badder L.M.","Novo D.","Knight E.G.","Marlow R.","Haider S.","Callen E.","Hewitt G.","Schimmel J.","Prevo R.","Alli C.","Ferdinand A.","Bell C.","Blencowe P.","Bot C.","Calder M.","Charles M.","Curry J.","Ekwuru T.","Ewings K.","Krajewski W.","MacDonald E.","McCarron H.","Pang L.","Pedder C.","Rigoreau L.","Swarbrick M.","Wheatley E.","Willis S.","Wong A.C.","Nussenzweig A.","Tijsterman M.","Tutt A.","Boulton S.J.","Higgins G.S.","Pettitt S.J.","Smith G.C.M.","Lord C.J."],"citationCrossReferences":[{"database":"PubMed","id":"34140467"},{"database":"DOI","id":"10.1038/s41467-021-23463-8"}],"title":"Poltheta inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.","publicationDate":"2021","journal":"Nat. Commun.","firstPage":"3636","lastPage":"3636","volume":"12"},"referencePositions":["FUNCTION","ACTIVITY REGULATION"]},{"referenceNumber":30,"citation":{"id":"36455556","citationType":"journal article","authors":["Belan O.","Sebald M.","Adamowicz M.","Anand R.","Vancevska A.","Neves J.","Grinkevich V.","Hewitt G.","Segura-Bayona S.","Bellelli R.","Robinson H.M.R.","Higgins G.S.","Smith G.C.M.","West S.C.","Rueda D.S.","Boulton S.J."],"citationCrossReferences":[{"database":"PubMed","id":"36455556"},{"database":"DOI","id":"10.1016/j.molcel.2022.11.008"}],"title":"POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.","publicationDate":"2022","journal":"Mol. Cell","firstPage":"4664","lastPage":"4680","volume":"82"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","NO HELICASE ACTIVITY"]},{"referenceNumber":31,"citation":{"id":"37674080","citationType":"journal article","authors":["Gelot C.","Kovacs M.T.","Miron S.","Mylne E.","Haan A.","Boeffard-Dosierre L.","Ghouil R.","Popova T.","Dingli F.","Loew D.","Guirouilh-Barbat J.","Del Nery E.","Zinn-Justin S.","Ceccaldi R."],"citationCrossReferences":[{"database":"PubMed","id":"37674080"},{"database":"DOI","id":"10.1038/s41586-023-06506-6"}],"title":"Poltheta is phosphorylated by PLK1 to repair double-strand breaks in mitosis.","publicationDate":"2023","journal":"Nature","firstPage":"415","lastPage":"422","volume":"621"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH TOPBP1","PHOSPHORYLATION AT SER-1289; SER-1482; SER-1486; SER-1488; SER-1493; SER-1555; SER-1563; SER-1628; SER-1635 AND THR-1755","MUTAGENESIS OF 1482-SER--SER-1493"]},{"referenceNumber":32,"citation":{"id":"37440612","citationType":"journal article","authors":["Brambati A.","Sacco O.","Porcella S.","Heyza J.","Kareh M.","Schmidt J.C.","Sfeir A."],"citationCrossReferences":[{"database":"PubMed","id":"37440612"},{"database":"DOI","id":"10.1126/science.adh3694"}],"title":"RHINO directs MMEJ to repair DNA breaks in mitosis.","publicationDate":"2023","journal":"Science","firstPage":"653","lastPage":"660","volume":"381"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH RHNO1"]},{"referenceNumber":33,"citation":{"id":"38640889","citationType":"journal article","authors":["Carvajal-Maldonado D.","Zahn K.","Jensen R.","Wood R.D.","Doublie S."],"citationCrossReferences":[{"database":"PubMed","id":"38640889"},{"database":"DOI","id":"10.1016/j.molcel.2024.03.009"}],"title":"Human DNA polymerase theta does not harbor intrinsic nuclease activity.","publicationDate":"2024","journal":"Mol. Cell","firstPage":"1394","lastPage":"1395","volume":"84"},"referencePositions":["CAUTION"]},{"referenceNumber":34,"citation":{"id":"25775267","citationType":"journal article","authors":["Zahn K.E.","Averill A.M.","Aller P.","Wood R.D.","Doublie S."],"citationCrossReferences":[{"database":"PubMed","id":"25775267"},{"database":"DOI","id":"10.1038/nsmb.2993"}],"title":"Human DNA polymerase theta grasps the primer terminus to mediate DNA repair.","publicationDate":"2015","journal":"Nat. Struct. Mol. Biol.","firstPage":"304","lastPage":"311","volume":"22"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.90 ANGSTROMS) OF 1819-2590 IN COMPLEX WITH CA(2+) AND MG(2+)","FUNCTION","CATALYTIC ACTIVITY","COFACTOR","MUTAGENESIS OF SER-1977; LYS-2181; ARG-2202 AND ARG-2254"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X0P"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X0Q"}]},{"referenceNumber":35,"citation":{"id":"26636256","citationType":"journal article","authors":["Newman J.A.","Cooper C.D.O.","Aitkenhead H.","Gileadi O."],"citationCrossReferences":[{"database":"PubMed","id":"26636256"},{"database":"DOI","id":"10.1016/j.str.2015.10.014"}],"title":"Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology-mediated end-joining pathway.","publicationDate":"2015","journal":"Structure","firstPage":"2319","lastPage":"2330","volume":"23"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 67-894 IN COMPLEX WITH ADP","FUNCTION","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5A9F"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5A9J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5AGA"}]},{"referenceNumber":36,"citation":{"id":"34117057","citationType":"journal article","authors":["Chandramouly G.","Zhao J.","McDevitt S.","Rusanov T.","Hoang T.","Borisonnik N.","Treddinick T.","Lopezcolorado F.W.","Kent T.","Siddique L.A.","Mallon J.","Huhn J.","Shoda Z.","Kashkina E.","Brambati A.","Stark J.M.","Chen X.S.","Pomerantz R.T."],"citationCrossReferences":[{"database":"PubMed","id":"34117057"},{"database":"DOI","id":"10.1126/sciadv.abf1771"}],"title":"Poltheta reverse transcribes RNA and promotes RNA-templated DNA repair.","publicationDate":"2021","journal":"Sci. Adv.","firstPage":"0","lastPage":"0","volume":"7"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.29 ANGSTROMS) OF 1819-2590","FUNCTION","CATALYTIC ACTIVITY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6XBU"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF052573","properties":[{"key":"ProteinId","value":"AAC33565.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY338826","properties":[{"key":"ProteinId","value":"AAR08421.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC069239","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC079841","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF043628","properties":[{"key":"ProteinId","value":"AAD05272.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS33833.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O75417-1"},{"database":"RefSeq","id":"NP_955452.3","properties":[{"key":"NucleotideSequenceId","value":"NM_199420.4"}],"isoformId":"O75417-1"},{"database":"PDB","id":"4X0P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.91 A"},{"key":"Chains","value":"A/B/C/D=1792-2590"}]},{"database":"PDB","id":"4X0Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"A/B=1819-2590"}]},{"database":"PDB","id":"5A9F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=67-894"}]},{"database":"PDB","id":"5A9J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.55 A"},{"key":"Chains","value":"A/B/C/D=1-894"}]},{"database":"PDB","id":"5AGA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=67-894"}]},{"database":"PDB","id":"6XBU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.29 A"},{"key":"Chains","value":"A=1819-1860, A=1896-1917, A=1935-2145, A=2176-2260, A=2265-2512, A=2527-2590"}]},{"database":"PDB","id":"7ZUS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.26 A"},{"key":"Chains","value":"AAA/BBB/CCC=1820-2590"}]},{"database":"PDB","id":"7ZX0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.99 A"},{"key":"Chains","value":"AAA/BBB/CCC/DDD/EEE/FFF=1820-2590"}]},{"database":"PDB","id":"7ZX1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.83 A"},{"key":"Chains","value":"AAA/BBB/CCC/DDD/EEE/FFF=1820-2590"}]},{"database":"PDB","id":"8E23","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.59 A"},{"key":"Chains","value":"A/D=1818-2590"}]},{"database":"PDB","id":"8E24","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.34 A"},{"key":"Chains","value":"A/D=1818-2590"}]},{"database":"PDB","id":"8GD7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.24 A"},{"key":"Chains","value":"A=1819-2590"}]},{"database":"PDB","id":"8W0A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/C=1-894"}]},{"database":"PDB","id":"9ASJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B=1-894"}]},{"database":"PDB","id":"9ASK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A/B=1-894"}]},{"database":"PDB","id":"9ASL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B/C/D=1-894"}]},{"database":"PDB","id":"9AU5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.11 A"},{"key":"Chains","value":"A=1792-2590"}]},{"database":"PDB","id":"9AU8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.44 A"},{"key":"Chains","value":"A=1792-2590"}]},{"database":"PDB","id":"9AU9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.32 A"},{"key":"Chains","value":"A=1792-2590"}]},{"database":"PDB","id":"9BH6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A/B/C/D=2-894"}]},{"database":"PDB","id":"9BH7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B=2-894"}]},{"database":"PDB","id":"9BH8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A/B=2-894"}]},{"database":"PDB","id":"9BH9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B=2-894"}]},{"database":"PDB","id":"9BHA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B=2-894"}]},{"database":"PDB","id":"9BP9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.21 A"},{"key":"Chains","value":"A/C=1-894"}]},{"database":"PDB","id":"9BPA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.21 A"},{"key":"Chains","value":"A/C/E/G=1-894"}]},{"database":"PDB","id":"9C5Q","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/C=68-891"}]},{"database":"PDB","id":"9D6N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.43 A"},{"key":"Chains","value":"A/B=1819-1860, A/B=1863-2515, A/B=2525-2590"}]},{"database":"PDB","id":"9D6O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.31 A"},{"key":"Chains","value":"A=1819-1860, A=1863-2515, A=2525-2590"}]},{"database":"PDB","id":"9OSW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.67 A"},{"key":"Chains","value":"A/B/C/D=1-904"}]},{"database":"PDB","id":"9OSY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B/C/D=1-904"}]},{"database":"PDBsum","id":"4X0P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4X0Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5A9F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5A9J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5AGA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XBU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZUS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZX0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZX1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8E23","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8E24","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GD7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8W0A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ASJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ASK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ASL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9AU5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9AU8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9AU9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BH6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BH7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BH8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BH9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BHA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BP9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BPA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9C5Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9D6N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9D6O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OSW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OSY","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43706","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43816","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43817","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43818","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43855","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43874","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43875","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44534","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44535","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44536","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44537","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44538","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44765","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44766","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45218","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70812","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70813","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"115946","properties":[{"key":"Interactions","value":"23"}]},{"database":"DIP","id":"DIP-61500N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O75417","properties":[{"key":"Number of interactors","value":"2403"}]},{"database":"IntAct","id":"O75417","properties":[{"key":"Interactions","value":"9"}]},{"database":"STRING","id":"9606.ENSP00000264233","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6025","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB12151","properties":[{"key":"GenericName","value":"Brincidofovir"}]},{"database":"GuidetoPHARMACOLOGY","id":"3230","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"O75417","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"POLQ","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5890","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000264233","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"49988","properties":[{"key":"Description","value":"-"}],"isoformId":"O75417-1"},{"database":"ProteomicsDB","id":"49989","properties":[{"key":"Description","value":"-"}],"isoformId":"O75417-2"},{"database":"Pumba","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"32825","properties":[{"key":"antibodies","value":"78 antibodies from 25 providers"}]},{"database":"DNASU","id":"10721","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000264233.6","properties":[{"key":"ProteinId","value":"ENSP00000264233.5"},{"key":"GeneId","value":"ENSG00000051341.16"}],"isoformId":"O75417-1"},{"database":"GeneID","id":"10721","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:10721","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000264233.6","properties":[{"key":"ProteinId","value":"ENSP00000264233.5"},{"key":"RefSeqNucleotideId","value":"NM_199420.4"},{"key":"RefSeqProteinId","value":"NP_955452.3"}]},{"database":"UCSC","id":"uc003eee.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"O75417-1"},{"database":"AGR","id":"HGNC:9186","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA33506","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10721","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10721","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"POLQ","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9186","properties":[{"key":"GeneName","value":"POLQ"}]},{"database":"HPA","id":"ENSG00000051341","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (bone marrow, lymphoid tissue)"}]},{"database":"MalaCards","id":"POLQ","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"114480","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"604419","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000051341","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000051341","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0950","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158694","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000818_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2320933at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O75417","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-5685939","properties":[{"key":"PathwayName","value":"HDR through MMEJ (alt-NHEJ)"}]},{"database":"SABIO-RK","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000051341","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"10721","properties":[{"key":"hits","value":"114 hits in 1159 CRISPR screens"}]},{"database":"ChiTaRS","id":"POLQ","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"O75417","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"POLQ","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"10721","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O75417","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:O75417","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"O75417","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000051341","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 113 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O75417","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25642963"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34179826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37440612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37674080"}]},{"database":"GO","id":"GO:0042645","properties":[{"key":"GoTerm","value":"C:mitochondrial nucleoid"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29509408"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29509408"}]},{"database":"GO","id":"GO:0090734","properties":[{"key":"GoTerm","value":"C:site of DNA damage"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34179826"}]},{"database":"GO","id":"GO:0035861","properties":[{"key":"GoTerm","value":"C:site of double-strand break"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37440612"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37674080"}]},{"database":"GO","id":"GO:0043138","properties":[{"key":"GoTerm","value":"F:3'-5' DNA helicase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0051575","properties":[{"key":"GoTerm","value":"F:5'-deoxyribose-5-phosphate lyase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19188258"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36455556"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25642963"}]},{"database":"GO","id":"GO:0003684","properties":[{"key":"GoTerm","value":"F:damaged DNA binding"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10395804"}]},{"database":"GO","id":"GO:0003678","properties":[{"key":"GoTerm","value":"F:DNA helicase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36455556"}]},{"database":"GO","id":"GO:0034061","properties":[{"key":"GoTerm","value":"F:DNA polymerase activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14576298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22135286"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311885"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27591252"}]},{"database":"GO","id":"GO:0003887","properties":[{"key":"GoTerm","value":"F:DNA-directed DNA polymerase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14576298"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25643323"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27311885"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27591252"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31562312"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34140467"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34179826"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25775267"}]},{"database":"GO","id":"GO:0003964","properties":[{"key":"GoTerm","value":"F:RNA-directed DNA polymerase activity"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"34117057"}]},{"database":"GO","id":"GO:0017116","properties":[{"key":"GoTerm","value":"F:single-stranded DNA helicase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14576298"}]},{"database":"GO","id":"GO:0006284","properties":[{"key":"GoTerm","value":"P:base-excision repair"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19188258"}]},{"database":"GO","id":"GO:0006974","properties":[{"key":"GoTerm","value":"P:DNA damage response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25642963"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25643323"}]},{"database":"GO","id":"GO:0006281","properties":[{"key":"GoTerm","value":"P:DNA repair"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10395804"}]},{"database":"GO","id":"GO:0006302","properties":[{"key":"GoTerm","value":"P:double-strand break repair"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22135286"}]},{"database":"GO","id":"GO:0097681","properties":[{"key":"GoTerm","value":"P:double-strand break repair via alternative nonhomologous end joining"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25643323"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25775267"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27311885"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27591252"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31562312"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32234782"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34179826"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36455556"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37440612"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37674080"}]},{"database":"GO","id":"GO:0042276","properties":[{"key":"GoTerm","value":"P:error-prone translesion synthesis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30655289"}]},{"database":"GO","id":"GO:2000042","properties":[{"key":"GoTerm","value":"P:negative regulation of double-strand break repair via homologous recombination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25642963"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36455556"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25643323"}]},{"database":"GO","id":"GO:0031297","properties":[{"key":"GoTerm","value":"P:replication fork processing"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30655289"}]},{"database":"GO","id":"GO:0016446","properties":[{"key":"GoTerm","value":"P:somatic hypermutation of immunoglobulin genes"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd18026","properties":[{"key":"EntryName","value":"DEXHc_POLQ-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd08638","properties":[{"key":"EntryName","value":"DNA_pol_A_theta"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd18795","properties":[{"key":"EntryName","value":"SF2_C_Ski2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.3380.20:FF:000001","properties":[{"key":"EntryName","value":"DNA polymerase theta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.10:FF:000066","properties":[{"key":"EntryName","value":"DNA polymerase theta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000885","properties":[{"key":"EntryName","value":"DNA polymerase theta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.20:FF:000036","properties":[{"key":"EntryName","value":"Polymerase (DNA directed), theta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1060.10:FF:000002","properties":[{"key":"EntryName","value":"Polymerase (DNA directed), theta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000753","properties":[{"key":"EntryName","value":"Polymerase (DNA directed), theta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.3380.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.370","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.20","properties":[{"key":"EntryName","value":"5' to 3' exonuclease, C-terminal subdomain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.420.10","properties":[{"key":"EntryName","value":"Ribonuclease H-like superfamily/Ribonuclease H"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1060.10","properties":[{"key":"EntryName","value":"Taq DNA Polymerase, Chain T, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00761","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR011545","properties":[{"key":"EntryName","value":"DEAD/DEAH_box_helicase_dom"}]},{"database":"InterPro","id":"IPR019760","properties":[{"key":"EntryName","value":"DNA-dir_DNA_pol_A_CS"}]},{"database":"InterPro","id":"IPR001098","properties":[{"key":"EntryName","value":"DNA-dir_DNA_pol_A_palm_dom"}]},{"database":"InterPro","id":"IPR043502","properties":[{"key":"EntryName","value":"DNA/RNA_pol_sf"}]},{"database":"InterPro","id":"IPR002298","properties":[{"key":"EntryName","value":"DNA_polymerase_A"}]},{"database":"InterPro","id":"IPR057220","properties":[{"key":"EntryName","value":"DUF7898"}]},{"database":"InterPro","id":"IPR014001","properties":[{"key":"EntryName","value":"Helicase_ATP-bd"}]},{"database":"InterPro","id":"IPR001650","properties":[{"key":"EntryName","value":"Helicase_C-like"}]},{"database":"InterPro","id":"IPR046931","properties":[{"key":"EntryName","value":"HTH_61"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR048960","properties":[{"key":"EntryName","value":"POLQ-like_helical"}]},{"database":"InterPro","id":"IPR012337","properties":[{"key":"EntryName","value":"RNaseH-like_sf"}]},{"database":"InterPro","id":"IPR036397","properties":[{"key":"EntryName","value":"RNaseH_sf"}]},{"database":"PANTHER","id":"PTHR10133","properties":[{"key":"EntryName","value":"DNA POLYMERASE I"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10133:SF62","properties":[{"key":"EntryName","value":"DNA POLYMERASE THETA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00270","properties":[{"key":"EntryName","value":"DEAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00476","properties":[{"key":"EntryName","value":"DNA_pol_A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25453","properties":[{"key":"EntryName","value":"DUF7898"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00271","properties":[{"key":"EntryName","value":"Helicase_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20470","properties":[{"key":"EntryName","value":"HTH_61"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21099","properties":[{"key":"EntryName","value":"POLQ_helical"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00868","properties":[{"key":"EntryName","value":"DNAPOLI"}]},{"database":"SMART","id":"SM00487","properties":[{"key":"EntryName","value":"DEXDc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00490","properties":[{"key":"EntryName","value":"HELICc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00482","properties":[{"key":"EntryName","value":"POLAc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56672","properties":[{"key":"EntryName","value":"DNA/RNA polymerases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53098","properties":[{"key":"EntryName","value":"Ribonuclease H-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF158702","properties":[{"key":"EntryName","value":"Sec63 N-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00447","properties":[{"key":"EntryName","value":"DNA_POLYMERASE_A"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51192","properties":[{"key":"EntryName","value":"HELICASE_ATP_BIND_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51194","properties":[{"key":"EntryName","value":"HELICASE_CTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQSHEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDISRTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFEDSFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQHPLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDSQLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKLTGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQEVISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV","length":2590,"molWeight":289619,"crc64":"F5550BED2DAD8013","md5":"B5B13CDED60832C617B450167C09FE73"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":5,"COFACTOR":1,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DOMAIN":2,"PTM":1,"DISEASE":1,"SIMILARITY":1,"CAUTION":2,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":2,"Region":10,"Motif":1,"Compositional bias":4,"Binding site":5,"Modified residue":11,"Alternative sequence":2,"Natural variant":1,"Mutagenesis":8,"Sequence conflict":5,"Helix":91,"Beta strand":60,"Turn":14},"uniParcId":"UPI0000D61B5F"}}