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Mediates asymmetric arginine dimethylation of histone H4 'Arg-3' (H4R3me2a) in the promoter region of miRNA miR-3648, to promote its transcription and osteogenesis (PubMed:31378783)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48100"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:11990"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:65280"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33495566"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48101"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33495566"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48096"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:11991"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61897"}],"ecNumber":"2.1.1.319","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22795084"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23445220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25728001"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33495566"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"39513743"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48097"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22795084"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23445220"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25728001"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33495566"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"39513743"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O70467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22795084"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23445220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25728001"}],"value":"Inhibited by N-ethylmaleimide and high concentrations of zinc chloride (By similarity). 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