{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O60216","secondaryAccessions":["A8K0E0","Q15001","Q99568"],"uniProtkbId":"RAD21_HUMAN","entryAudit":{"firstPublicDate":"2002-11-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-11-15","entryVersion":215,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Double-strand-break repair protein rad21 homolog"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8812457"}],"value":"hHR21"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10623634"}],"value":"Nuclear matrix protein 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10623634"}],"value":"NXP-1"}]},{"fullName":{"value":"SCC1 homolog"}}],"contains":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12417729"}],"value":"64-kDa C-terminal product"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12417729"}],"value":"64-kDa carboxy-terminal product"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11875078"}],"value":"65-kDa carboxy-terminal product"}}]}]},"genes":[{"geneName":{"value":"RAD21"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11483345"}],"value":"HR21"},{"value":"KIAA0078"},{"value":"NXP1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11509732"}],"value":"SCC1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q61550"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6TEL1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11509732"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11590136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25575569"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25575569"}],"value":"As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity)"}],"commentType":"FUNCTION","molecule":"Double-strand-break repair protein rad21 homolog"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11875078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}],"value":"May promote apoptosis"}],"commentType":"FUNCTION","molecule":"64-kDa C-terminal product"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10931856"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11590136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15837422"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17105772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19696148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22628566"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25575569"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32409525"}],"value":"Component of the cohesin complex, which consists of an SMC1A/B and SMC3 heterodimer core and 2 non-Smc subunits RAD21 and STAG1/SA1, STAG2/SA2 or STAG3/SA3 (PubMed:10931856, PubMed:11590136, PubMed:22628566, PubMed:25575569, PubMed:32409525). Interacts (via C-terminus) with SMC1A and (via N-terminus) with SMC3; these interactions are direct (PubMed:12198550, PubMed:32409525). The cohesin complex interacts with NUMA1 (PubMed:11590136). The cohesin complex also interacts with CDCA5, PDS5A and PDS5B; this interaction might regulate the ability of the cohesin complex to mediate sister chromatid cohesion (PubMed:15837422). The interaction with PDS5B is direct and is stimulated by STAG1/SA1 (PubMed:19696148). The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4 (PubMed:22628566). NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (PubMed:32409525). The cohesin complex interacts with DDX11/ChIR1 (PubMed:17105772). Directly interacts with WAPL; this interaction is stimulated by STAG1/SA1 (PubMed:19696148). Interacts with the ISWI chromatin remodeling complex component SMARCA5/SNF2h; the interaction is direct (PubMed:12198550). Interacts with the NuRD complex component CHD4; the interaction is direct (PubMed:12198550)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O60216","intActId":"EBI-80739"},"interactantTwo":{"uniProtKBAccession":"Q14674","geneName":"ESPL1","intActId":"EBI-2554882"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60216","intActId":"EBI-80739"},"interactantTwo":{"uniProtKBAccession":"Q13643","geneName":"FHL3","intActId":"EBI-741101"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60216","intActId":"EBI-80739"},"interactantTwo":{"uniProtKBAccession":"Q29RF7","geneName":"PDS5A","intActId":"EBI-1175454"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60216","intActId":"EBI-80739"},"interactantTwo":{"uniProtKBAccession":"Q9NTI5","geneName":"PDS5B","intActId":"EBI-1175604"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60216","intActId":"EBI-80739"},"interactantTwo":{"uniProtKBAccession":"Q14683","geneName":"SMC1A","intActId":"EBI-80690"},"numberOfExperiments":19,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60216","intActId":"EBI-80739"},"interactantTwo":{"uniProtKBAccession":"Q9UQE7","geneName":"SMC3","intActId":"EBI-80718"},"numberOfExperiments":19,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60216","intActId":"EBI-80739"},"interactantTwo":{"uniProtKBAccession":"Q9NP77","geneName":"SSU72","intActId":"EBI-2515416"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60216","intActId":"EBI-80739"},"interactantTwo":{"uniProtKBAccession":"Q8N3U4","geneName":"STAG2","intActId":"EBI-1057252"},"numberOfExperiments":23,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60216","intActId":"EBI-80739"},"interactantTwo":{"uniProtKBAccession":"Q7Z5K2","geneName":"WAPL","intActId":"EBI-1022242"},"numberOfExperiments":19,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Double-strand-break repair protein rad21 homolog","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11073952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11509732"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11590136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11931760"}],"value":"Associates with chromatin (PubMed:11073952, PubMed:11590136). Before prophase, scattered along chromosome arms (PubMed:11073952). During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (PubMed:11931760). A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (PubMed:11073952, PubMed:11509732)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11073952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11509732"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10623634"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11590136"}],"value":"Nucleus matrix","id":"SL-0181"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11073952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11590136"}],"value":"Chromosome","id":"SL-0468"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11073952"}],"value":"Chromosome, centromere","id":"SL-0047"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11073952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11590136"}],"value":"Cytoplasm, cytoskeleton, spindle pole","id":"SL-0448"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"64-kDa C-terminal product","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11875078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11875078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25575569"}],"value":"Expressed in the gut (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11073952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8812457"}],"value":"Regulated in a cell cycle-dependent manner: expression increases in late S phase and reaches maximum in G2 at the nucleotide level (PubMed:8812457). Not regulated during the cell cycle (at protein level) (PubMed:11073952)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32409525"}],"value":"The C-terminal part associates with the ATPase head of SMC1A, while the N-terminal part binds to the ATPase head of SMC3"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11509732"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11875078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}],"value":"Cleaved by separase/ESPL1 at the onset of anaphase; this cleavage is required for sister chromatid separation and cytokinesis (PubMed:11509732). Cleaved by caspase-3/CASP3 or caspase-7/CASP7 at the beginning of apoptosis (PubMed:11875078, PubMed:12417729)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11073952"}],"value":"Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to its phosphorylation by PLK1"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Cornelia de Lange syndrome 4 with or without midline brain defects","diseaseAccession":"DI-03491","acronym":"CDLS4","description":"A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. It is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.","diseaseCrossReference":{"database":"MIM","id":"614701"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22633399"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31334757"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Mungan syndrome","diseaseAccession":"DI-05340","acronym":"MGS","description":"An autosomal recessive disease characterized by visceral neuromyopathy, intestinal dysmotility and chronic intestinal pseudoobstruction, megaduodenum, long-segment Barrett esophagus, and a variety of cardiac valve or septal defects such as membranous ventricular septal defect, pulmonary and tricuspid valve regurgitation.","diseaseCrossReference":{"database":"MIM","id":"611376"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25575569"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the rad21 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA07554.2","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":631,"modifier":"EXACT"}},"description":"Double-strand-break repair protein rad21 homolog","featureId":"PRO_0000097872"},{"type":"Chain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":631,"modifier":"EXACT"}},"description":"64-kDa C-terminal product","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}],"featureId":"PRO_0000446317"},{"type":"Region","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Required for interaction with SMARCA5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198550"}]},{"type":"Region","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Interaction with NIPBL","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32409525"}]},{"type":"Region","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Interaction with WAPL and PDS5B","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19696148"}]},{"type":"Region","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Interaction with STAG1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19696148"}]},{"type":"Region","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":522,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":533,"modifier":"EXACT"},"end":{"value":551,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Cleavage; by ESPL1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11509732"}]},{"type":"Site","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Cleavage; by caspase-3 or caspase-7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}]},{"type":"Site","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Cleavage; by ESPL1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11509732"}]},{"type":"Modified residue","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":545,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":623,"modifier":"EXACT"},"end":{"value":623,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Cross-link","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Natural variant","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":631,"modifier":"EXACT"}},"description":"in CDLS4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31334757"}],"featureId":"VAR_083980","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"in CDLS4; dbSNP:rs387907212","featureCrossReferences":[{"database":"dbSNP","id":"rs387907212"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22633399"}],"featureId":"VAR_068691","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"found in a radiation-sensitive cancer patient; dbSNP:rs755168088","featureCrossReferences":[{"database":"dbSNP","id":"rs755168088"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11483345"}],"featureId":"VAR_014281","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":585,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"in CDLS4; dbSNP:rs387907213","featureCrossReferences":[{"database":"dbSNP","id":"rs387907213"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22633399"}],"featureId":"VAR_068692","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"in MGS; causes delayed food transit along the gut, when tested in zebrafish; may affect RUNX1 and APOB expression; dbSNP:rs775266057","featureCrossReferences":[{"database":"dbSNP","id":"rs775266057"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25575569"}],"featureId":"VAR_081285","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Abolishes interaction with SMC1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198550"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Abolishes binding to SMARCA5.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198550"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Abolishes first cleavage by ESPL1, no effect on nuclear localization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11509732"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Loss of cleavage by caspase-3 or caspase-7.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}],"alternativeSequence":{"originalSequence":"DSPDS","alternativeSequences":["AAPAA"]}},{"type":"Mutagenesis","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Loss of cleavage by caspase-3 or caspase-7.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11875078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A","E"]}},{"type":"Mutagenesis","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"No effect on cleavage by caspase-3 or caspase-7.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11875078"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"Abolishes second cleavage by ESPL1, no effect on nuclear localization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11509732"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"in Ref. 1; CAA66940","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Beta strand","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROK"}]},{"type":"Helix","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROK"}]},{"type":"Helix","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROK"}]},{"type":"Helix","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROK"}]},{"type":"Helix","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROK"}]},{"type":"Helix","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROK"}]},{"type":"Helix","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HN5"}]},{"type":"Helix","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HN5"}]},{"type":"Helix","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6RRC"}]},{"type":"Helix","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMV"}]},{"type":"Helix","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Turn","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4PK7"}]},{"type":"Helix","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMS"}]},{"type":"Helix","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HN0"}]},{"type":"Beta strand","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMS"}]},{"type":"Helix","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HN4"}]},{"type":"Helix","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HN4"}]},{"type":"Helix","location":{"start":{"value":468,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HN4"}]},{"type":"Turn","location":{"start":{"value":569,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROC"}]},{"type":"Helix","location":{"start":{"value":581,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROE"}]},{"type":"Turn","location":{"start":{"value":585,"modifier":"EXACT"},"end":{"value":587,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROE"}]},{"type":"Helix","location":{"start":{"value":590,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROE"}]},{"type":"Beta strand","location":{"start":{"value":608,"modifier":"EXACT"},"end":{"value":615,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROE"}]},{"type":"Beta strand","location":{"start":{"value":620,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ROE"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0137","category":"Cellular component","name":"Centromere"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0159","category":"Biological process","name":"Chromosome partition"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"8812457","citationType":"journal article","authors":["McKay M.J.","Troelstra C.","van der Spek P.","Kanaar R.","Smit B.","Hagemeijer A.","Bootsma D.","Hoeijmakers J.H.J."],"citationCrossReferences":[{"database":"PubMed","id":"8812457"},{"database":"DOI","id":"10.1006/geno.1996.0466"}],"title":"Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse.","publicationDate":"1996","journal":"Genomics","firstPage":"305","lastPage":"315","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"7584044","citationType":"journal article","authors":["Nomura N.","Nagase T.","Miyajima N.","Sazuka T.","Tanaka A.","Sato S.","Seki N.","Kawarabayasi Y.","Ishikawa K.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"7584044"},{"database":"DOI","id":"10.1093/dnares/1.5.223"}],"title":"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.","publicationDate":"1994","journal":"DNA Res.","firstPage":"223","lastPage":"229","volume":"1"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-86ALB6QA9JIIK","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"JUL-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Cerebellum","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"10931856","citationType":"journal article","authors":["Losada A.","Yokochi T.","Kobayashi R.","Hirano T."],"citationCrossReferences":[{"database":"PubMed","id":"10931856"},{"database":"DOI","id":"10.1083/jcb.150.3.405"}],"title":"Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes.","publicationDate":"2000","journal":"J. Cell Biol.","firstPage":"405","lastPage":"416","volume":"150"},"referencePositions":["IDENTIFICATION IN THE COHESIN COMPLEX"]},{"referenceNumber":8,"citation":{"id":"11590136","citationType":"journal article","authors":["Gregson H.C.","Schmiesing J.A.","Kim J.-S.","Kobayashi T.","Zhou S.","Yokomori K."],"citationCrossReferences":[{"database":"PubMed","id":"11590136"},{"database":"DOI","id":"10.1074/jbc.m103364200"}],"title":"A potential role for human cohesin in mitotic spindle aster assembly.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"47575","lastPage":"47582","volume":"276"},"referencePositions":["PROTEIN SEQUENCE OF 406-418","IDENTIFICATION IN THE COHESIN COMPLEX","INTERACTION WITH NUMA1","SUBCELLULAR LOCATION","FUNCTION"]},{"referenceNumber":9,"citation":{"id":"11931760","citationType":"journal article","authors":["Sumara I.","Vorlaufer E.","Stukenberg P.T.","Kelm O.","Redemann N.","Nigg E.A.","Peters J.-M."],"citationCrossReferences":[{"database":"PubMed","id":"11931760"},{"database":"DOI","id":"10.1016/s1097-2765(02)00473-2"}],"title":"The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase.","publicationDate":"2002","journal":"Mol. Cell","firstPage":"515","lastPage":"525","volume":"9"},"referencePositions":["PHOSPHORYLATION BY PLK1"]},{"referenceNumber":10,"citation":{"id":"12417729","citationType":"journal article","authors":["Pati D.","Zhang N.","Plon S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12417729"},{"database":"DOI","id":"10.1128/mcb.22.23.8267-8277.2002"}],"title":"Linking sister chromatid cohesion and apoptosis: role of rad21.","publicationDate":"2002","journal":"Mol. Cell. Biol.","firstPage":"8267","lastPage":"8277","volume":"22"},"referencePositions":["PROTEIN SEQUENCE OF 280-286 (64-KDA C-TERMINAL PRODUCT)","CLEAVAGE BY CASPASE-3 OR CASPASE-7","FUNCTION","MUTAGENESIS OF 276-ASP--SER-280 AND ASP-279","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"10623634","citationType":"journal article","authors":["Sadano H.","Sugimoto H.","Sakai F.","Nomura N.","Osumi T."],"citationCrossReferences":[{"database":"PubMed","id":"10623634"},{"database":"DOI","id":"10.1006/bbrc.1999.1969"}],"title":"NXP-1, a human protein related to Rad21/Scc1/Mcd1, is a component of the nuclear matrix.","publicationDate":"2000","journal":"Biochem. Biophys. Res. Commun.","firstPage":"418","lastPage":"422","volume":"267"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":12,"citation":{"id":"11073952","citationType":"journal article","authors":["Hoque M.T.","Ishikawa F."],"citationCrossReferences":[{"database":"PubMed","id":"11073952"},{"database":"DOI","id":"10.1074/jbc.m007809200"}],"title":"Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"5059","lastPage":"5067","volume":"276"},"referencePositions":["SUBCELLULAR LOCATION","DEVELOPMENTAL STAGE","PHOSPHORYLATION"]},{"referenceNumber":13,"citation":{"id":"11509732","citationType":"journal article","authors":["Hauf S.","Waizenegger I.C.","Peters J.-M."],"citationCrossReferences":[{"database":"PubMed","id":"11509732"},{"database":"DOI","id":"10.1126/science.1061376"}],"title":"Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.","publicationDate":"2001","journal":"Science","firstPage":"1320","lastPage":"1323","volume":"293"},"referencePositions":["FUNCTION","CLEAVAGE BY ESPL1","MUTAGENESIS OF ARG-172 AND ARG-450","SUBCELLULAR LOCATION"]},{"referenceNumber":14,"citation":{"id":"11875078","citationType":"journal article","authors":["Chen F.","Kamradt M.","Mulcahy M.","Byun Y.","Xu H.","McKay M.J.","Cryns V.L."],"citationCrossReferences":[{"database":"PubMed","id":"11875078"},{"database":"DOI","id":"10.1074/jbc.m201322200"}],"title":"Caspase proteolysis of the cohesin component RAD21 promotes apoptosis.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"16775","lastPage":"16781","volume":"277"},"referencePositions":["FUNCTION","CLEAVAGE BY CASPASE-3 OR CASPASE-7","SUBCELLULAR LOCATION","MUTAGENESIS OF ASP-279 AND ASP-282"]},{"referenceNumber":15,"citation":{"id":"12198550","citationType":"journal article","authors":["Hakimi M.-A.","Bochar D.A.","Schmiesing J.A.","Dong Y.","Barak O.G.","Speicher D.W.","Yokomori K.","Shiekhattar R."],"citationCrossReferences":[{"database":"PubMed","id":"12198550"},{"database":"DOI","id":"10.1038/nature01024"}],"title":"A chromatin remodelling complex that loads cohesin onto human chromosomes.","publicationDate":"2002","journal":"Nature","firstPage":"994","lastPage":"998","volume":"418"},"referencePositions":["INTERACTION WITH SMARCA5; SMC1A AND CHD4","MUTAGENESIS OF 1-MET--ASP-126 AND 126-ASP--ASP-282"]},{"referenceNumber":16,"citation":{"id":"15837422","citationType":"journal article","authors":["Rankin S.","Ayad N.G.","Kirschner M.W."],"citationCrossReferences":[{"database":"PubMed","id":"15837422"},{"database":"DOI","id":"10.1016/j.molcel.2005.03.017"}],"title":"Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.","publicationDate":"2005","journal":"Mol. Cell","firstPage":"185","lastPage":"200","volume":"18"},"referencePositions":["INTERACTION WITH CDCA5; PDS5A AND PDS5B"]},{"referenceNumber":17,"citation":{"id":"CI-AJON8EU8OKM21","citationType":"journal article","authors":["Rankin S.","Ayad N.G.","Kirschner M.W."],"publicationDate":"2005","journal":"Mol. Cell","firstPage":"609","lastPage":"609","volume":"18"},"referencePositions":["ERRATUM OF PUBMED:15837422"]},{"referenceNumber":18,"citation":{"id":"17105772","citationType":"journal article","authors":["Parish J.L.","Rosa J.","Wang X.","Lahti J.M.","Doxsey S.J.","Androphy E.J."],"citationCrossReferences":[{"database":"PubMed","id":"17105772"},{"database":"DOI","id":"10.1242/jcs.03262"}],"title":"The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.","publicationDate":"2006","journal":"J. Cell Sci.","firstPage":"4857","lastPage":"4865","volume":"119"},"referencePositions":["INTERACTION WITH DDX11"]},{"referenceNumber":19,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-175","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":20,"citation":{"id":"19696148","citationType":"journal article","authors":["Shintomi K.","Hirano T."],"citationCrossReferences":[{"database":"PubMed","id":"19696148"},{"database":"DOI","id":"10.1101/gad.1844309"}],"title":"Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.","publicationDate":"2009","journal":"Genes Dev.","firstPage":"2224","lastPage":"2236","volume":"23"},"referencePositions":["INTERACTION WITH PDS5B; STAG1 AND WAPL"]},{"referenceNumber":21,"citation":{"id":"11483345","citationType":"journal article","authors":["Severin D.M.","Leong T.","Cassidy B.","Elsaleh H.","Peters L.","Venter D.","Southey M.","McKay M."],"citationCrossReferences":[{"database":"PubMed","id":"11483345"},{"database":"DOI","id":"10.1016/s0360-3016(01)01608-x"}],"title":"Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients.","publicationDate":"2001","journal":"Int. J. Radiat. Oncol. Biol. Phys.","firstPage":"1323","lastPage":"1331","volume":"50"},"referencePositions":["VARIANT ARG-481"]},{"referenceNumber":22,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153 AND SER-175","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-153","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":25,"citation":{"id":"22628566","citationType":"journal article","authors":["Bermudez V.P.","Farina A.","Higashi T.L.","Du F.","Tappin I.","Takahashi T.S.","Hurwitz J."],"citationCrossReferences":[{"database":"PubMed","id":"22628566"},{"database":"DOI","id":"10.1073/pnas.1206840109"}],"title":"In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9366","lastPage":"9371","volume":"109"},"referencePositions":["IDENTIFICATION IN THE COHESIN COMPLEX","INTERACTION WITH NIPBL AND MAU2"]},{"referenceNumber":26,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394; SER-454; SER-545 AND THR-623","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153 AND SER-249","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":28,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-48; LYS-216 AND LYS-418","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"32409525","citationType":"journal article","authors":["Shi Z.","Gao H.","Bai X.C.","Yu H."],"citationCrossReferences":[{"database":"PubMed","id":"32409525"},{"database":"DOI","id":"10.1126/science.abb0981"}],"title":"Cryo-EM structure of the human cohesin-NIPBL-DNA complex.","publicationDate":"2020","journal":"Science","firstPage":"1454","lastPage":"1459","volume":"368"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.90 ANGSTROMS)","IDENTIFICATION IN THE COHESIN COMPLEX","INTERACTION WITH NIPBL"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6WG3"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6WGE"}]},{"referenceNumber":30,"citation":{"id":"22633399","citationType":"journal article","authors":["Deardorff M.A.","Wilde J.J.","Albrecht M.","Dickinson E.","Tennstedt S.","Braunholz D.","Monnich M.","Yan Y.","Xu W.","Gil-Rodriguez M.C.","Clark D.","Hakonarson H.","Halbach S.","Michelis L.D.","Rampuria A.","Rossier E.","Spranger S.","Van Maldergem L.","Lynch S.A.","Gillessen-Kaesbach G.","Ludecke H.J.","Ramsay R.G.","McKay M.J.","Krantz I.D.","Xu H.","Horsfield J.A.","Kaiser F.J."],"citationCrossReferences":[{"database":"PubMed","id":"22633399"},{"database":"DOI","id":"10.1016/j.ajhg.2012.04.019"}],"title":"RAD21 mutations cause a human cohesinopathy.","publicationDate":"2012","journal":"Am. J. Hum. Genet.","firstPage":"1014","lastPage":"1027","volume":"90"},"referencePositions":["INVOLVEMENT IN CDLS4","VARIANTS CDLS4 ARG-376 AND ARG-585"]},{"referenceNumber":31,"citation":{"id":"25575569","citationType":"journal article","authors":["Bonora E.","Bianco F.","Cordeddu L.","Bamshad M.","Francescatto L.","Dowless D.","Stanghellini V.","Cogliandro R.F.","Lindberg G.","Mungan Z.","Cefle K.","Ozcelik T.","Palanduz S.","Ozturk S.","Gedikbasi A.","Gori A.","Pippucci T.","Graziano C.","Volta U.","Caio G.","Barbara G.","D'Amato M.","Seri M.","Katsanis N.","Romeo G.","De Giorgio R."],"citationCrossReferences":[{"database":"PubMed","id":"25575569"},{"database":"DOI","id":"10.1053/j.gastro.2014.12.034"}],"title":"Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstruction.","publicationDate":"2015","journal":"Gastroenterology","firstPage":"771","lastPage":"782","volume":"148"},"referencePositions":["INVOLVEMENT IN MGS","VARIANT MGS THR-622","CHARACTERIZATION OF VARIANT MGS THR-622","FUNCTION","INTERACTION WITH SMC1","TISSUE SPECIFICITY"]},{"referenceNumber":32,"citation":{"id":"31334757","citationType":"journal article","authors":["Kruszka P.","Berger S.I.","Casa V.","Dekker M.R.","Gaesser J.","Weiss K.","Martinez A.F.","Murdock D.R.","Louie R.J.","Prijoles E.J.","Lichty A.W.","Brouwer O.F.","Zonneveld-Huijssoon E.","Stephan M.J.","Hogue J.","Hu P.","Tanima-Nagai M.","Everson J.L.","Prasad C.","Cereda A.","Iascone M.","Schreiber A.","Zurcher V.","Corsten-Janssen N.","Escobar L.","Clegg N.J.","Delgado M.R.","Hajirnis O.","Balasubramanian M.","Kayserili H.","Deardorff M.","Poot R.A.","Wendt K.S.","Lipinski R.J.","Muenke M."],"citationCrossReferences":[{"database":"PubMed","id":"31334757"},{"database":"DOI","id":"10.1093/brain/awz210"}],"title":"Cohesin complex-associated holoprosencephaly.","publicationDate":"2019","journal":"Brain","firstPage":"2631","lastPage":"2643","volume":"142"},"referencePositions":["VARIANT CDLS4 197-GLN--ILE-631 DEL"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X98294","properties":[{"key":"ProteinId","value":"CAA66940.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D38551","properties":[{"key":"ProteinId","value":"BAA07554.2"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY675320","properties":[{"key":"ProteinId","value":"AAT70725.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK289505","properties":[{"key":"ProteinId","value":"BAF82194.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471060","properties":[{"key":"ProteinId","value":"EAW91963.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC050381","properties":[{"key":"ProteinId","value":"AAH50381.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS6321.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_006256.1","properties":[{"key":"NucleotideSequenceId","value":"NM_006265.3"}]},{"database":"PDB","id":"4PJU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"B=281-420"}]},{"database":"PDB","id":"4PJW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"B=281-420"}]},{"database":"PDB","id":"4PK7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"B=281-420"}]},{"database":"PDB","id":"6QNX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B=281-420"}]},{"database":"PDB","id":"6RRC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.37 A"},{"key":"Chains","value":"B/D=321-345"}]},{"database":"PDB","id":"6RRK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.17 A"},{"key":"Chains","value":"C/D=356-395"}]},{"database":"PDB","id":"6WG3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.30 A"},{"key":"Chains","value":"C=1-631"}]},{"database":"PDB","id":"6WGE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"C=1-631"}]},{"database":"PDB","id":"7W1M","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.50 A"},{"key":"Chains","value":"C=1-631"}]},{"database":"PDB","id":"7ZJS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.24 A"},{"key":"Chains","value":"B/D=1-631"}]},{"database":"PDB","id":"8K4D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.52 A"},{"key":"Chains","value":"B=281-420"}]},{"database":"PDB","id":"8P0A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.67 A"},{"key":"Chains","value":"C=558-629"}]},{"database":"PDB","id":"8PQ5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.40 A"},{"key":"Chains","value":"C=558-629"}]},{"database":"PDB","id":"8RO6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B=558-629"}]},{"database":"PDB","id":"8RO7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"B=558-629"}]},{"database":"PDB","id":"8RO8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"B=558-629"}]},{"database":"PDB","id":"8RO9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.77 A"},{"key":"Chains","value":"B/D=558-629"}]},{"database":"PDB","id":"8ROA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.44 A"},{"key":"Chains","value":"B/D=558-629"}]},{"database":"PDB","id":"8ROB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B=558-629"}]},{"database":"PDB","id":"8ROC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"B=558-629"}]},{"database":"PDB","id":"8ROD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"B=558-629"}]},{"database":"PDB","id":"8ROE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.36 A"},{"key":"Chains","value":"B=558-629"}]},{"database":"PDB","id":"8ROF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"B=558-629"}]},{"database":"PDB","id":"8ROG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.94 A"},{"key":"Chains","value":"B=558-629"}]},{"database":"PDB","id":"8ROH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B=1-102"}]},{"database":"PDB","id":"8ROI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"B=1-102"}]},{"database":"PDB","id":"8ROJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"B=1-102"}]},{"database":"PDB","id":"8ROK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"B/D=1-102"}]},{"database":"PDB","id":"8ROL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.11 A"},{"key":"Chains","value":"B=1-102"}]},{"database":"PDB","id":"9EP3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.08 A"},{"key":"Chains","value":"B=281-420"}]},{"database":"PDB","id":"9HMS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"B=310-550"}]},{"database":"PDB","id":"9HMV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B=310-550"}]},{"database":"PDB","id":"9HN0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=310-550"}]},{"database":"PDB","id":"9HN4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.93 A"},{"key":"Chains","value":"A=310-550"}]},{"database":"PDB","id":"9HN5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.96 A"},{"key":"Chains","value":"B=100-320"}]},{"database":"PDB","id":"9HVY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A=1-631"}]},{"database":"PDBsum","id":"4PJU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4PJW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4PK7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6QNX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RRC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RRK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WG3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WGE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7W1M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZJS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8K4D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8P0A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PQ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RO6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RO7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RO8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8RO9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ROL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EP3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HMS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HMV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HN0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HN4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HN5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HVY","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17331","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17820","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21658","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21663","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32252","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-4029","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-4030","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-4031","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52297","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52298","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52303","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52306","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52307","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111822","properties":[{"key":"Interactions","value":"414"}]},{"database":"ComplexPortal","id":"CPX-5989","properties":[{"key":"EntryName","value":"Nuclear mitotic cohesin complex, STAG1 variant"}]},{"database":"ComplexPortal","id":"CPX-5991","properties":[{"key":"EntryName","value":"Nuclear mitotic cohesin complex, STAG2 variant"}]},{"database":"ComplexPortal","id":"CPX-6082","properties":[{"key":"EntryName","value":"Nuclear meiotic cohesin complex, RAD21 variant"}]},{"database":"CORUM","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-29201N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O60216","properties":[{"key":"Number of interactors","value":"4618"}]},{"database":"IntAct","id":"O60216","properties":[{"key":"Interactions","value":"118"}]},{"database":"MINT","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-RAD21","properties":[{"key":"Evidences","value":"9 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000297338","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"O60216","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"RAD21","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000297338","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"49246","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"13592","properties":[{"key":"antibodies","value":"355 antibodies from 39 providers"}]},{"database":"DNASU","id":"5885","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000297338.7","properties":[{"key":"ProteinId","value":"ENSP00000297338.2"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000517485.6","properties":[{"key":"ProteinId","value":"ENSP00000427923.2"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000517749.2","properties":[{"key":"ProteinId","value":"ENSP00000430273.2"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000519837.6","properties":[{"key":"ProteinId","value":"ENSP00000430524.2"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000520992.6","properties":[{"key":"ProteinId","value":"ENSP00000429342.2"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000522699.2","properties":[{"key":"ProteinId","value":"ENSP00000428158.2"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000687358.1","properties":[{"key":"ProteinId","value":"ENSP00000509687.1"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000900009.1","properties":[{"key":"ProteinId","value":"ENSP00000570068.1"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000900010.1","properties":[{"key":"ProteinId","value":"ENSP00000570069.1"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000927340.1","properties":[{"key":"ProteinId","value":"ENSP00000597399.1"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"Ensembl","id":"ENST00000958519.1","properties":[{"key":"ProteinId","value":"ENSP00000628578.1"},{"key":"GeneId","value":"ENSG00000164754.17"}]},{"database":"GeneID","id":"5885","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5885","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000297338.7","properties":[{"key":"ProteinId","value":"ENSP00000297338.2"},{"key":"RefSeqNucleotideId","value":"NM_006265.3"},{"key":"RefSeqProteinId","value":"NP_006256.1"}]},{"database":"UCSC","id":"uc003yod.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:9811","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA34170","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5885","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5885","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"RAD21","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"RAD21","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9811","properties":[{"key":"GeneName","value":"RAD21"}]},{"database":"HPA","id":"ENSG00000164754","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"RAD21","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"606462","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"611376","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"614701","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000164754","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"199","properties":[{"key":"Disease","value":"Cornelia de Lange syndrome"}]},{"database":"Orphanet","id":"502","properties":[{"key":"Disease","value":"Trichorhinophalangeal syndrome type 2"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000164754","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1213","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154655","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_015775_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HEDYEFP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10071381at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O60216","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:ENSG00000164754-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1221632","properties":[{"key":"PathwayName","value":"Meiotic synapsis"}]},{"database":"Reactome","id":"R-HSA-2467813","properties":[{"key":"PathwayName","value":"Separation of Sister Chromatids"}]},{"database":"Reactome","id":"R-HSA-2468052","properties":[{"key":"PathwayName","value":"Establishment of Sister Chromatid Cohesion"}]},{"database":"Reactome","id":"R-HSA-2470946","properties":[{"key":"PathwayName","value":"Cohesin Loading onto Chromatin"}]},{"database":"Reactome","id":"R-HSA-2500257","properties":[{"key":"PathwayName","value":"Resolution of Sister Chromatid Cohesion"}]},{"database":"Reactome","id":"R-HSA-3108214","properties":[{"key":"PathwayName","value":"SUMOylation of DNA damage response and repair proteins"}]},{"database":"Reactome","id":"R-HSA-9018519","properties":[{"key":"PathwayName","value":"Estrogen-dependent gene expression"}]},{"database":"SignaLink","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000164754","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"5885","properties":[{"key":"hits","value":"728 hits in 1136 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"ChiTaRS","id":"RAD21","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"O60216","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"RAD21","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5885","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O60216","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:O60216","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"O60216","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000164754","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 215 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O60216","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11073952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11590136"}]},{"database":"GO","id":"GO:0000775","properties":[{"key":"GoTerm","value":"C:chromosome, centromeric region"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0008278","properties":[{"key":"GoTerm","value":"C:cohesin complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11590136"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22628566"}]},{"database":"GO","id":"GO:0000794","properties":[{"key":"GoTerm","value":"C:condensed nuclear chromosome"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030893","properties":[{"key":"GoTerm","value":"C:meiotic cohesin complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0030892","properties":[{"key":"GoTerm","value":"C:mitotic cohesin complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23242214"}]},{"database":"GO","id":"GO:0016363","properties":[{"key":"GoTerm","value":"C:nuclear matrix"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11590136"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11073952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11509732"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11875078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12417729"}]},{"database":"GO","id":"GO:0000922","properties":[{"key":"GoTerm","value":"C:spindle pole"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000987","properties":[{"key":"GoTerm","value":"F:cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0140297","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0106222","properties":[{"key":"GoTerm","value":"F:lncRNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006310","properties":[{"key":"GoTerm","value":"P:DNA recombination"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8812457"}]},{"database":"GO","id":"GO:0006302","properties":[{"key":"GoTerm","value":"P:double-strand break repair"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8812457"}]},{"database":"GO","id":"GO:0034089","properties":[{"key":"GoTerm","value":"P:establishment of meiotic sister chromatid cohesion"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32409525"}]},{"database":"GO","id":"GO:0034087","properties":[{"key":"GoTerm","value":"P:establishment of mitotic sister chromatid cohesion"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32409525"}]},{"database":"GO","id":"GO:0010972","properties":[{"key":"GoTerm","value":"P:negative regulation of G2/M transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034351","properties":[{"key":"GoTerm","value":"P:negative regulation of glial cell apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032691","properties":[{"key":"GoTerm","value":"P:negative regulation of interleukin-1 beta production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045841","properties":[{"key":"GoTerm","value":"P:negative regulation of mitotic metaphase/anaphase transition"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043524","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032720","properties":[{"key":"GoTerm","value":"P:negative regulation of tumor necrosis factor production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032733","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-10 production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045876","properties":[{"key":"GoTerm","value":"P:positive regulation of sister chromatid cohesion"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18499658"}]},{"database":"GO","id":"GO:0071168","properties":[{"key":"GoTerm","value":"P:protein localization to chromatin"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21111234"}]},{"database":"GO","id":"GO:0007131","properties":[{"key":"GoTerm","value":"P:reciprocal meiotic recombination"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8812457"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19468298"}]},{"database":"GO","id":"GO:1990414","properties":[{"key":"GoTerm","value":"P:replication-born double-strand break repair via sister chromatid exchange"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd21792","properties":[{"key":"EntryName","value":"Rad21_Rec8_M_NXP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.580:FF:000001","properties":[{"key":"EntryName","value":"double-strand-break repair protein rad21 homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.580","properties":[{"key":"EntryName","value":"Structural maintenance of chromosome 1. Chain E"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00642","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR049589","properties":[{"key":"EntryName","value":"NXP1_M-like"}]},{"database":"InterPro","id":"IPR039781","properties":[{"key":"EntryName","value":"Rad21/Rec8-like"}]},{"database":"InterPro","id":"IPR006909","properties":[{"key":"EntryName","value":"Rad21/Rec8_C_eu"}]},{"database":"InterPro","id":"IPR006910","properties":[{"key":"EntryName","value":"Rad21_Rec8_N"}]},{"database":"InterPro","id":"IPR023093","properties":[{"key":"EntryName","value":"ScpA-like_C"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR12585:SF20","properties":[{"key":"EntryName","value":"DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21 HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12585","properties":[{"key":"EntryName","value":"SCC1 / RAD21 FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04824","properties":[{"key":"EntryName","value":"Rad21_Rec8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04825","properties":[{"key":"EntryName","value":"Rad21_Rec8_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSRLQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII","length":631,"molWeight":71690,"crc64":"7D4A6EA6392BE73D","md5":"2D00B37F6C0E81E0A1BA49C0731F454E"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"INTERACTION":9,"SUBCELLULAR LOCATION":2,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DOMAIN":1,"PTM":2,"DISEASE":2,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":2,"Region":7,"Compositional bias":4,"Site":3,"Modified residue":8,"Cross-link":3,"Natural variant":5,"Mutagenesis":7,"Sequence conflict":1,"Beta strand":4,"Helix":19,"Turn":3},"uniParcId":"UPI0000133018"}}