{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O59045","uniProtkbId":"Y1321_PYRHO","entryAudit":{"firstPublicDate":"2003-07-11","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1998-08-01","entryVersion":96,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)","taxonId":70601,"lineage":["Archaea","Methanobacteriati","Methanobacteriota","Thermococci","Thermococcales","Thermococcaceae","Pyrococcus"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"UPF0252 protein PH1321"}}},"genes":[{"orderedLocusNames":[{"value":"PH1321"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0252 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"UPF0252 protein PH1321","featureId":"PRO_0000159561"},{"type":"Transmembrane","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9679194","citationType":"journal article","authors":["Kawarabayasi Y.","Sawada M.","Horikawa H.","Haikawa Y.","Hino Y.","Yamamoto S.","Sekine M.","Baba S.","Kosugi H.","Hosoyama A.","Nagai Y.","Sakai M.","Ogura K.","Otsuka R.","Nakazawa H.","Takamiya M.","Ohfuku Y.","Funahashi T.","Tanaka T.","Kudoh Y.","Yamazaki J.","Kushida N.","Oguchi A.","Aoki K.","Yoshizawa T.","Nakamura Y.","Robb F.T.","Horikoshi K.","Masuchi Y.","Shizuya H.","Kikuchi H."],"citationCrossReferences":[{"database":"PubMed","id":"9679194"},{"database":"DOI","id":"10.1093/dnares/5.2.55"}],"title":"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3.","publicationDate":"1998","journal":"DNA Res.","firstPage":"55","lastPage":"76","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BA000001","properties":[{"key":"ProteinId","value":"BAA30427.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"C71003","properties":[{"key":"EntryName","value":"C71003"}]},{"database":"RefSeq","id":"WP_010885413.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000961.1"}]},{"database":"AlphaFoldDB","id":"O59045","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O59045","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"70601.gene:9378294","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"BAA30427","properties":[{"key":"ProteinId","value":"BAA30427"},{"key":"GeneId","value":"BAA30427"}]},{"database":"GeneID","id":"1443650","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"pho:PH1321","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"arCOG07144","properties":[{"key":"ToxonomicScope","value":"Archaea"}]},{"database":"OrthoDB","id":"86147at2157","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000752","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"Gene3D","id":"3.10.620.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007562","properties":[{"key":"EntryName","value":"Transglutaminase-like_domain"}]},{"database":"Pfam","id":"PF04473","properties":[{"key":"EntryName","value":"DUF553"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQEYKELIKECAKELEGLMPEISQKLVNIAKINSPDRAFLEYLKVVEQVSLMKTERKQKNKALIILWRYGEALEKELYSDVKFFAKPLHKRIFRFVDWKIIGMLFLVFIILPAITSNLWSFRSEHYVLYLNENVDFPRELCNYRTSWLYDFRTSMVCVLKYGYGSINVTLRGNSWEKGVEAQRFISDMEYDFDRVKSPITYIQTPKETLRYKKGVCSDFALLVANILLDNNVSPVYIVHTVVRKEPSGGHAAAGIYVNGTLWILDWGSKPTKFQEYLENIDRIWEIREVRIYRITRDRITLERIYKARLEDDRWRFLYSVIIMLGIFILKRREWWIM","length":337,"molWeight":40240,"crc64":"63F38D12BA6DA765","md5":"A193A584DE6A0DD930B5D4C3433121C5"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":1},"uniParcId":"UPI0000063050"}}