{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O44518","secondaryAccessions":["Q95YG2"],"uniProtkbId":"CYFIP_CAEEL","entryAudit":{"firstPublicDate":"2007-03-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":142,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Caenorhabditis elegans","taxonId":6239,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Nematoda","Chromadorea","Rhabditida","Rhabditina","Rhabditomorpha","Rhabditoidea","Rhabditidae","Peloderinae","Caenorhabditis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cytoplasmic FMR1-interacting protein homolog"}},"alternativeNames":[{"fullName":{"value":"Gut on exterior protein 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"WormBase","id":"F56A11.1"}],"value":"gex-2"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"WormBase","id":"F56A11.1"}],"value":"F56A11.1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11877381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19798448"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27123983"}],"value":"Required for initial steps of body morphogenesis (PubMed:11877381). May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11877381"}],"value":"Interacts with gex-3"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O44518","intActId":"EBI-1570205"},"interactantTwo":{"uniProtKBAccession":"P55163","geneName":"gex-3","intActId":"EBI-1570181"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11877381"}],"value":"Enriched at cell boundaries"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11877381"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11877381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19798448"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27123983"}],"value":"Embryonic lethal with cells differentiating, but failing to become organized (PubMed:11877381). The external hypodermal cells fail to spread over and enclose the embryo, but instead cluster on the dorsal side (PubMed:11877381). In one study, animals are viable and there is defective extension of body wall muscle connections or arms towards the ventral nerve cord (PubMed:27123983). In this same study, double knockout with madd-3 results in severe muscle arm extension defects (PubMed:27123983). RNAi-mediated knockdown results in reduced egg laying and in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space (PubMed:19798448)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Belongs to the CYFIP family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1262,"modifier":"EXACT"}},"description":"Cytoplasmic FMR1-interacting protein homolog","featureId":"PRO_0000279713"},{"type":"Region","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-1185","category":"Technical 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growth and embryonic epidermal morphogenesis.","publicationDate":"2009","journal":"PLoS Genet.","firstPage":"E1000675","lastPage":"E1000675","volume":"5"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":4,"citation":{"id":"27123983","citationType":"journal article","authors":["D'Souza S.A.","Rajendran L.","Bagg R.","Barbier L.","van Pel D.M.","Moshiri H.","Roy P.J."],"citationCrossReferences":[{"database":"PubMed","id":"27123983"},{"database":"DOI","id":"10.1371/journal.pgen.1006010"}],"title":"The MADD-3 LAMMER kinase interacts with a p38 MAP kinase pathway to regulate the display of the EVA-1 guidance receptor in Caenorhabditis elegans.","publicationDate":"2016","journal":"PLoS Genet.","firstPage":"E1006010","lastPage":"E1006010","volume":"12"},"referencePositions":["FUNCTION","DISRUPTION 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