{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O43426","secondaryAccessions":["O43425","O94984","Q4KMR1"],"uniProtkbId":"SYNJ1_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-25","entryVersion":224,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Polyphosphatidylinositol phosphatase SYNJ1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"9428629"}],"value":"Synaptojanin-1"}}],"includes":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"SAC-like phosphoinositide phosphatase SYNJ1"}},"alternativeNames":[{"fullName":{"value":"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase SYNJ1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10224048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"}],"value":"3.1.3.95"}]},{"fullName":{"value":"Phosphatidylinositol-4-phosphatase SYNJ1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10224048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"}],"value":"3.1.3.-"}]}]},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Phosphoinositide 5-phosphatase SYNJ1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40969890"}],"value":"3.1.3.36"}]},"alternativeNames":[{"fullName":{"value":"Inositol polyphosphate-5-phosphatase G"}},{"fullName":{"value":"Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1"}}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:11503"}],"value":"SYNJ1"},"synonyms":[{"value":"INPP5G"},{"value":"KIAA0910"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O18964"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CHC4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10224048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40969890"}],"value":"Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner (PubMed:10224048, PubMed:18093523, PubMed:23804563, PubMed:27435091, PubMed:33349335, PubMed:40969890). The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (PubMed:18093523, PubMed:23804563, PubMed:27435091, PubMed:33349335, PubMed:40969890). The SAC domain hydrolyzes phosphates at the 3- and 4-positions of the inositol ring, targeting phosphatidylinositol-3-phosphate (PI(3)P), phosphatidylinositol-4-phosphate (PI(4)P), and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) (PubMed:10224048, PubMed:18093523, PubMed:23804563, PubMed:27435091). Plays a role in the phosphatidylinositol metabolic process during an unconventional endocytic mechanism, the ultrafast endocytosis where it participates in the rapide neck formation of the newly generated synaptic vesicle through its phosphoinositide 5-phosphatase activity (By similarity). Also, participates in the clathrin uncoating of synaptc vesicle formed via budding from synaptic endosomes after ultrafast endocytosis through combined activity of its phosphatase domains (By similarity). Additionally, regulates actin filament rearrangement by hydrolyzing PIP2 bound to actin regulatory proteins (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12316"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57880"},{"database":"ChEBI","id":"CHEBI:58088"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10224048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:12317"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:55652"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57880"},{"database":"ChEBI","id":"CHEBI:58178"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10224048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:55653"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45836"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:65221"},{"database":"ChEBI","id":"CHEBI:85468"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45837"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:39019"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57795"},{"database":"ChEBI","id":"CHEBI:57923"}],"ecNumber":"3.1.3.95","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10224048"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:39020"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10224048"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22764"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58178"},{"database":"ChEBI","id":"CHEBI:58456"}],"ecNumber":"3.1.3.36","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:22765"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19797"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58282"},{"database":"ChEBI","id":"CHEBI:203600"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40969890"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19798"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40969890"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11392"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57895"},{"database":"ChEBI","id":"CHEBI:58414"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62910"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11393"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62910"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:25528"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57658"},{"database":"ChEBI","id":"CHEBI:57836"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:25529"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43548"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:83416"},{"database":"ChEBI","id":"CHEBI:83417"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40969890"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43549"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40969890"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41147"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57795"},{"database":"ChEBI","id":"CHEBI:57880"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41148"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:42308"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:65221"},{"database":"ChEBI","id":"CHEBI:78911"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:42309"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:86551"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:83419"},{"database":"ChEBI","id":"CHEBI:85468"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:86552"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01427"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40969890"}],"value":"Inositol 1,4,5-trisphosphate 5-phosphatase is inhibited by epigallocatechin with an IC(50) of 0.51 uM for gambogic acid (GA) and epigallocatechin monogallate (EGCG) wih an IC(50) of 94 uM (PubMed:40969890). Gambogic acid is the more selective inhibitor and acts through a non competitive inhibition mechanism, (PubMed:40969890)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":18.0,"unit":"uM","substrate":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},{"constant":39.0,"unit":"uM","substrate":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (with Mg(2+))","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},{"constant":96.0,"unit":"uM","substrate":"1D-myo-inositol 1,4,5-trisphosphate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},{"constant":133.0,"unit":"uM","substrate":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},{"constant":289.0,"unit":"uM","substrate":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (without Mg(2+))","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},{"constant":16.0,"unit":"uM","substrate":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40969890"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40969890"}],"value":"kcat is 30.6 sec(-1) with 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) as substrate. kcat is 85.3 sec(-1) with 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) as substrate with Mg(2+). kcat is 16.4 sec(-1) with 1D-myo-inositol 1,4,5-trisphosphate as substrate. kcat is 0.09 sec(-1) with 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) as substrate. kcat is 0.06 sec(-1) with 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) as substrate without Mg(2+) (PubMed:33349335). kcat is 12.2 sec(-1) with 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) as substrate (PubMed:40969890)."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O18964"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62910"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CHC4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10542231"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17257598"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"}],"value":"Interacts with ASH/GRB2. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with AMPH, SH3GL1, SH3GL2 and SH3GL3 (PubMed:10542231, PubMed:18093523). Interacts with MYO1E (via SH3 domain) (PubMed:17257598). Interacts with BIN1 and DNM1 (By similarity). Interacts with EPS15 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O43426","intActId":"EBI-2821539"},"interactantTwo":{"uniProtKBAccession":"Q15811","geneName":"ITSN1","intActId":"EBI-602041"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62910"}],"value":"Concentrates at clathrin-coated endocytic intermediates in nerve terminals. Also recruited to clathrin- and dynamin-coated intermediates"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O18964"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"}],"value":"Presynapse","id":"SL-0516"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62910"}],"value":"Membrane","id":"SL-0162"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Synaptojanin-170"}],"isoformIds":["O43426-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Synaptojanin-145"}],"isoformIds":["O43426-2"],"sequenceIds":["VSP_002682","VSP_002683"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["O43426-4"],"sequenceIds":["VSP_041578","VSP_002682","VSP_002683"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["O43426-5"],"sequenceIds":["VSP_035709","VSP_035710","VSP_035711"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62910"}],"value":"Interacts with EPS15 (a clathrin coat-associated protein) via a C-terminal domain containing three Asn-Pro-Phe (NPF) repeats"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10542231"}],"value":"The C-terminal proline-rich region mediates binding to a variety of SH3 domain-containing proteins including AMPH, SH3GL1, SH3GL2 and SH3GL3"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10224048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"}],"value":"The SAC domain mediates phosphatidylinositol-3-phosphate phosphatase activity and phosphatidylinositol-4-phosphate phosphatase activity (PubMed:10224048, PubMed:18093523, PubMed:23804563, PubMed:27435091). Also dephosphorylates a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)(PI(3,5)P2) (PubMed:10224048, PubMed:23804563, PubMed:27435091). The SAC domain is required for uncoating vesicles (PubMed:18093523)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CHC4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18093523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27435091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}],"value":"The 5-PPase domain mediates phosphoinositide 5-phosphatase activity (PubMed:18093523, PubMed:23804563, PubMed:27435091, PubMed:33349335). The preferred substrates of the 5-phosphatase domain are PI(4,5)P2 and PI(3,4,5)P3 (PubMed:23804563, PubMed:27435091, PubMed:33349335). The 5-phosphatase domain is required for the neck formation of endocytic pits during ultrafast endocytosis and uncoating vesicles (By similarity)"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Parkinson disease 20, early-onset","diseaseAccession":"DI-03964","acronym":"PARK20","description":"An early-onset form of Parkinson disease, a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK20 is characterized by young adult-onset of parkinsonism. Additional features may include seizures, cognitive decline, abnormal eye movements, and dystonia.","diseaseCrossReference":{"database":"MIM","id":"615530"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23804577"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27496670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28502045"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31751865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33349335"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Developmental and epileptic encephalopathy 53","diseaseAccession":"DI-04961","acronym":"DEE53","description":"A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. 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