{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O34707","uniProtkbId":"YTPB_BACSU","entryAudit":{"firstPublicDate":"2003-07-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-01-01","entryVersion":108,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Bacillus subtilis (strain 168)","taxonId":224308,"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Bacillaceae","Bacillus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Tetraprenyl-beta-curcumene synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21627333"}],"value":"4.2.3.130"}]}},"genes":[{"geneName":{"value":"ytpB"},"orderedLocusNames":[{"value":"BSU30500"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21627333"}],"value":"Catalyzes the transformation of a linear C35 prenyl diphosphate chain to form tetraprenyl-beta-curcumene"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"all-trans-heptaprenyl diphosphate = (R)-tetraprenyl-beta-curcumene + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:33123"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58206"},{"database":"ChEBI","id":"CHEBI:64801"}],"ecNumber":"4.2.3.130","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21627333"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the large terpene synthase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"Tetraprenyl-beta-curcumene synthase","featureId":"PRO_0000049901"}],"keywords":[{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"9387221","citationType":"journal article","authors":["Lapidus A.","Galleron N.","Sorokin A.","Ehrlich S.D."],"citationCrossReferences":[{"database":"PubMed","id":"9387221"},{"database":"DOI","id":"10.1099/00221287-143-11-3431"}],"title":"Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.","publicationDate":"1997","journal":"Microbiology","firstPage":"3431","lastPage":"3441","volume":"143"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9384377","citationType":"journal article","authors":["Kunst F.","Ogasawara N.","Moszer I.","Albertini A.M.","Alloni G.","Azevedo V.","Bertero M.G.","Bessieres P.","Bolotin A.","Borchert S.","Borriss R.","Boursier L.","Brans A.","Braun M.","Brignell S.C.","Bron S.","Brouillet S.","Bruschi C.V.","Caldwell B.","Capuano V.","Carter N.M.","Choi S.-K.","Codani J.-J.","Connerton I.F.","Cummings N.J.","Daniel R.A.","Denizot F.","Devine K.M.","Duesterhoeft A.","Ehrlich S.D.","Emmerson P.T.","Entian K.-D.","Errington J.","Fabret C.","Ferrari E.","Foulger D.","Fritz C.","Fujita M.","Fujita Y.","Fuma S.","Galizzi A.","Galleron N.","Ghim S.-Y.","Glaser P.","Goffeau A.","Golightly E.J.","Grandi G.","Guiseppi G.","Guy B.J.","Haga K.","Haiech J.","Harwood C.R.","Henaut A.","Hilbert H.","Holsappel S.","Hosono S.","Hullo M.-F.","Itaya M.","Jones L.-M.","Joris B.","Karamata D.","Kasahara Y.","Klaerr-Blanchard M.","Klein C.","Kobayashi Y.","Koetter P.","Koningstein G.","Krogh S.","Kumano M.","Kurita K.","Lapidus A.","Lardinois S.","Lauber J.","Lazarevic V.","Lee S.-M.","Levine A.","Liu H.","Masuda S.","Mauel C.","Medigue C.","Medina N.","Mellado R.P.","Mizuno M.","Moestl D.","Nakai S.","Noback M.","Noone D.","O'Reilly M.","Ogawa K.","Ogiwara A.","Oudega B.","Park S.-H.","Parro V.","Pohl T.M.","Portetelle D.","Porwollik S.","Prescott A.M.","Presecan E.","Pujic P.","Purnelle B.","Rapoport G.","Rey M.","Reynolds S.","Rieger M.","Rivolta C.","Rocha E.","Roche B.","Rose M.","Sadaie Y.","Sato T.","Scanlan E.","Schleich S.","Schroeter R.","Scoffone F.","Sekiguchi J.","Sekowska A.","Seror S.J.","Serror P.","Shin B.-S.","Soldo B.","Sorokin A.","Tacconi E.","Takagi T.","Takahashi H.","Takemaru K.","Takeuchi M.","Tamakoshi A.","Tanaka T.","Terpstra P.","Tognoni A.","Tosato V.","Uchiyama S.","Vandenbol M.","Vannier F.","Vassarotti A.","Viari A.","Wambutt R.","Wedler E.","Wedler H.","Weitzenegger T.","Winters P.","Wipat A.","Yamamoto H.","Yamane K.","Yasumoto K.","Yata K.","Yoshida K.","Yoshikawa H.-F.","Zumstein E.","Yoshikawa H.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"9384377"},{"database":"DOI","id":"10.1038/36786"}],"title":"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.","publicationDate":"1997","journal":"Nature","firstPage":"249","lastPage":"256","volume":"390"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"21627333","citationType":"journal article","authors":["Sato T.","Yoshida S.","Hoshino H.","Tanno M.","Nakajima M.","Hoshino T."],"citationCrossReferences":[{"database":"PubMed","id":"21627333"},{"database":"DOI","id":"10.1021/ja203779h"}],"title":"Sesquarterpenes (C35 terpenes) biosynthesized via the cyclization of a linear C35 isoprenoid by a tetraprenyl-beta-curcumene synthase and a tetraprenyl-beta-curcumene cyclase: identification of a new terpene cyclase.","publicationDate":"2011","journal":"J. Am. Chem. Soc.","firstPage":"9734","lastPage":"9737","volume":"133"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF008220","properties":[{"key":"ProteinId","value":"AAC00246.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL009126","properties":[{"key":"ProteinId","value":"CAB15028.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"E69998","properties":[{"key":"EntryName","value":"E69998"}]},{"database":"RefSeq","id":"WP_004399076.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"AlphaFoldDB","id":"O34707","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O34707","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O34707","properties":[{"key":"Number of interactors","value":"12"}]},{"database":"STRING","id":"224308.BSU30500","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"224308-BSU30500","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"CAB15028","properties":[{"key":"ProteinId","value":"CAB15028"},{"key":"GeneId","value":"BSU_30500"}]},{"database":"GeneID","id":"936222","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"bsu:BSU30500","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|224308.179.peg.3308","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"eggNOG","id":"ENOG502Z812","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"O34707","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2371262at2","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"BSUB:BSU30500-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"4.2.3.130","properties":[{"key":"OrganismId","value":"656"}]},{"database":"Proteomes","id":"UP000001570","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"O34707","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR019712","properties":[{"key":"EntryName","value":"YtpB-like"}]},{"database":"Pfam","id":"PF10776","properties":[{"key":"EntryName","value":"DUF2600"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDFRMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLLELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVAYSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMMDRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC","length":367,"molWeight":42843,"crc64":"7E9CC567E5DB6E4B","md5":"58B480CBD33F01D6135EAD80C4ED8128"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI0000060940"}}