{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O32870","uniProtkbId":"Y007_MYCLE","entryAudit":{"firstPublicDate":"2001-11-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-01-01","entryVersion":105,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Mycobacterium leprae (strain TN)","taxonId":272631,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Mycobacteriales","Mycobacteriaceae","Mycobacterium"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein ML0007"}}},"genes":[{"orderedLocusNames":[{"value":"ML0007"}],"orfNames":[{"value":"MLB1770.07"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"To M.tuberculosis Rv0007"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Uncharacterized protein ML0007","featureId":"PRO_0000103638"},{"type":"Transmembrane","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6O12KN1BL02VD","citationType":"submission","authors":["Fsihi H.","Salazar L.","Takiff H.E.","Cole S.T."],"publicationDate":"APR-1996","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"11234002","citationType":"journal article","authors":["Cole S.T.","Eiglmeier K.","Parkhill J.","James K.D.","Thomson N.R.","Wheeler P.R.","Honore N.","Garnier T.","Churcher C.M.","Harris D.E.","Mungall K.L.","Basham D.","Brown D.","Chillingworth T.","Connor R.","Davies R.M.","Devlin K.","Duthoy S.","Feltwell T.","Fraser A.","Hamlin N.","Holroyd S.","Hornsby T.","Jagels K.","Lacroix C.","Maclean J.","Moule S.","Murphy L.D.","Oliver K.","Quail M.A.","Rajandream M.A.","Rutherford K.M.","Rutter S.","Seeger K.","Simon S.","Simmonds M.","Skelton J.","Squares R.","Squares S.","Stevens K.","Taylor K.","Whitehead S.","Woodward J.R.","Barrell B.G."],"citationCrossReferences":[{"database":"PubMed","id":"11234002"},{"database":"DOI","id":"10.1038/35059006"}],"title":"Massive gene decay in the leprosy bacillus.","publicationDate":"2001","journal":"Nature","firstPage":"1007","lastPage":"1011","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"TN","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z70722","properties":[{"key":"ProteinId","value":"CAA94717.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL583917","properties":[{"key":"ProteinId","value":"CAC29515.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"T10007","properties":[{"key":"EntryName","value":"T10007"}]},{"database":"RefSeq","id":"WP_010907460.1","properties":[{"key":"NucleotideSequenceId","value":"NC_002677.1"}]},{"database":"AlphaFoldDB","id":"O32870","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O32870","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"272631.gene:17573816","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mle:ML0007","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|272631.5.peg.7","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"Leproma","id":"ML0007","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG3266","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_046697_0_1_11","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"3240216at2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000806","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR021949","properties":[{"key":"EntryName","value":"DUF3566_TM"}]},{"database":"InterPro","id":"IPR062015","properties":[{"key":"EntryName","value":"ML2630"}]},{"database":"Pfam","id":"PF12089","properties":[{"key":"EntryName","value":"DUF3566"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF29656","properties":[{"key":"EntryName","value":"ML2630"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTSPNESRAFNAADDLIGDGSVERAGLHRATSVPGESSEGLQRGHSPEPNDSPPWQRGSARASQSGYRPSDPLTTTRQSNPAPGANVRSNRFISGMTAPALSGQLPKKNNSTQALEPVLMSNEVPFTESYASELPDLSGPVQRTVPCKPSPDRGSSTPRMGRLEITKVRGTGEIRSQISRRSHGPVRASMQIRRIDPWSMLKVSLLLSVALFFVWMIAVAFLYLLLGGMGVWAKLNSNVGDLLNNTGGNSGELVSNSTIFGCAVLVGLVNIVLMTTMAAIAAFVYNLSSDLVGGVEVTLADLD","length":303,"molWeight":32237,"crc64":"9761DD87391C11E4","md5":"E11128557C4D80DB38125E7EC60D4CEF"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Region":2,"Compositional bias":1},"uniParcId":"UPI00001390C8"}}