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Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16469701"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23687264"}],"value":"By Spo0A during nutrient starvation, through its direct negative control of AbrB, repressed by AbrB during regular growth when nutrients are plentiful, and also by SdpR (PubMed:16469701). Induced by expression of SDP (active peptide of sdpC) (PubMed:16469701, PubMed:23687264)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16629676"}],"value":"Results in increased SigW expression which is dependent on SdpC. Results in weaker growth (70% of wild-type cell density) on LB medium, with more pronounced effects on sporulation medium (15% of wild-type). Concomitant deletion of SigW results in greatly diminished growth (5% of wild-type on LB and 3% on sporulation medium). Over time, single SdpI mutant stops growing on sporulation medium, while the SdpI SigW double mutant eventually lyses. Deletion of RsiW restores growth of the SdpI single mutant to near wild-type levels"}],"commentType":"DISRUPTION PHENOTYPE"},{"commentType":"WEB RESOURCE","resourceName":"Protein Spotlight","resourceUrl":"https://www.proteinspotlight.org/back_issues/090","ftp":false,"note":"I'll have you for supper - Issue 90 of January 2008"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Immunity protein SdpI","featureId":"PRO_0000312744"},{"type":"Transmembrane","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Mutagenesis","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16469701"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16469701"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16469701"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["I"]}},{"type":"Mutagenesis","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16469701"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16469701"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Ability to bypass the requirement of SdpC binding for expression of the sdpRI genes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16469701"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["K"]}},{"type":"Mutagenesis","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Loss of ability to promote transcription of the sdpRI genes in response to SdpC binding. 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