{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O18973","uniProtkbId":"RABX5_BOVIN","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-01-01","entryVersion":132,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Bos taurus","commonName":"Bovine","taxonId":9913,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Laurasiatheria","Artiodactyla","Ruminantia","Pecora","Bovidae","Bovinae","Bos"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Rab5 GDP/GTP exchange factor"}},"alternativeNames":[{"fullName":{"value":"Rabex-5"}}]},"genes":[{"geneName":{"value":"RABGEF1"},"synonyms":[{"value":"RABEX5"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16462746"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323142"}],"value":"Acts as a guanine-nucleotide releasing factor (GEF) for RAB5A by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:9323142). Forms a complex with RABEP1 that acts as Rab4/Rab5 effector regulating endosome fusion. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:9323142). Also functions as a ubiquitin ligase (PubMed:16462746)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2 (By similarity). Interacts with RAB21, and with 100-fold lower affinity also with RAB22 (By similarity). Interacts with ubiquitinated EGFR. Interacts with RGS14; the interaction is GTP-dependent (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O18973","intActId":"EBI-447376"},"interactantTwo":{"uniProtKBAccession":"P62990","geneName":"UBC","intActId":"EBI-413053"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O18973","intActId":"EBI-447376"},"interactantTwo":{"uniProtKBAccession":"Q9UJY5","geneName":"GGA1","intActId":"EBI-447141"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323142"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323142"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323142"}],"value":"Recycling endosome","id":"SL-0232"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323142"}],"value":"Detected in brain"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Monoubiquitinated"}],"commentType":"PTM"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"Rab5 GDP/GTP exchange factor","featureId":"PRO_0000191314"},{"type":"Domain","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"VPS9","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00550"}]},{"type":"Zinc finger","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"A20-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00451"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Interaction with ubiquitinated proteins"},{"type":"Region","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00451"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00451"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00451"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00451"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Modified residue","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UJ41"}]},{"type":"Modified residue","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UJ41"}]},{"type":"Modified residue","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UJ41"}]},{"type":"Modified residue","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UJ41"}]},{"type":"Modified residue","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UJ41"}]},{"type":"Modified residue","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UJ41"}]},{"type":"Modified residue","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JM13"}]},{"type":"Modified residue","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UJ41"}]},{"type":"Mutagenesis","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Strongly reduced ubiquitin binding. Loss of ubiquitin binding; when associated with D-58. Loss of ubiquitin ligase activity; when associated with A-26.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16462746"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A","P"]}},{"type":"Mutagenesis","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Strongly reduced ubiquitin binding. Loss of ubiquitin ligase activity; when associated with A-25.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16462746"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A","P"]}},{"type":"Mutagenesis","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Strongly reduced ubiquitin binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16462746"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Strongly reduced ubiquitin binding. Loss of ubiquitin binding; when associated with A-25.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16462746"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Beta strand","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2FIF"}]},{"type":"Helix","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2FIF"}]},{"type":"Helix","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2FIF"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0254","category":"Biological process","name":"Endocytosis"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"9323142","citationType":"journal article","authors":["Horiuchi H.","Lippe R.","McBride H.M.","Rubino M.","Woodman P.","Stenmark H.","Rybin V.","Wilm M.","Ashman K.","Mann M.","Zerial M."],"citationCrossReferences":[{"database":"PubMed","id":"9323142"},{"database":"DOI","id":"10.1016/s0092-8674(00)80380-3"}],"title":"A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function.","publicationDate":"1997","journal":"Cell","firstPage":"1149","lastPage":"1159","volume":"90"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","PROTEIN SEQUENCE OF 50-60; 142-148; 181-189; 272-283; 332-341 AND 414-427","FUNCTION","INTERACTION WITH RABEP1","IDENTIFICATION BY MASS SPECTROMETRY","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16462746","citationType":"journal article","authors":["Lee S.","Tsai Y.C.","Mattera R.","Smith W.J.","Kostelansky M.S.","Weissman A.M.","Bonifacino J.S.","Hurley J.H."],"citationCrossReferences":[{"database":"PubMed","id":"16462746"},{"database":"DOI","id":"10.1038/nsmb1064"}],"title":"Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.","publicationDate":"2006","journal":"Nat. Struct. Mol. Biol.","firstPage":"264","lastPage":"271","volume":"13"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-73 IN COMPLEX WITH UBIQUITIN","FUNCTION","UBIQUITINATION","MUTAGENESIS OF TYR-25; TYR-26; LEU-57 AND ALA-58"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ001119","properties":[{"key":"ProteinId","value":"CAA04545.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_777016.1","properties":[{"key":"NucleotideSequenceId","value":"NM_174591.1"}]},{"database":"PDB","id":"2FID","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B=9-73"}]},{"database":"PDB","id":"2FIF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.49 A"},{"key":"Chains","value":"B/D/F=9-73"}]},{"database":"PDBsum","id":"2FID","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2FIF","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O18973","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O18973","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"159596","properties":[{"key":"Interactions","value":"4"}]},{"database":"DIP","id":"DIP-29059N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O18973","properties":[{"key":"Number of interactors","value":"779"}]},{"database":"IntAct","id":"O18973","properties":[{"key":"Interactions","value":"8"}]},{"database":"STRING","id":"9913.ENSBTAP00000005011","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9913-ENSBTAP00000005011","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSBTAT00000143472.1","properties":[{"key":"ProteinId","value":"ENSBTAP00000104018.1"},{"key":"GeneId","value":"ENSBTAG00000003842.8"}]},{"database":"Ensembl","id":"ENSBTAT00085074017","properties":[{"key":"ProteinId","value":"ENSBTAP00085026736"},{"key":"GeneId","value":"ENSBTAG00085022055"}]},{"database":"Ensembl","id":"ENSBTAT00090053627","properties":[{"key":"ProteinId","value":"ENSBTAP00090027768"},{"key":"GeneId","value":"ENSBTAG00090025586"}]},{"database":"GeneID","id":"282335","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"bta:282335","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"27342","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2319","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG3173","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154540","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_018416_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O18973","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"300289at2759","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"O18973","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000009136","properties":[{"key":"Component","value":"Chromosome 25"}]},{"database":"ExpressionAtlas","id":"O18973","properties":[{"key":"ExpressionPatterns","value":"baseline"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323142"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323142"}]},{"database":"GO","id":"GO:0030139","properties":[{"key":"GoTerm","value":"C:endocytic vesicle"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0055037","properties":[{"key":"GoTerm","value":"C:recycling endosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323142"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005085","properties":[{"key":"GoTerm","value":"F:guanyl-nucleotide exchange factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016192","properties":[{"key":"GoTerm","value":"P:vesicle-mediated transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.246.120:FF:000002","properties":[{"key":"EntryName","value":"rab5 GDP/GTP exchange factor isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.4770:FF:000002","properties":[{"key":"EntryName","value":"rab5 GDP/GTP exchange factor isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1050.80:FF:000003","properties":[{"key":"EntryName","value":"rab5 GDP/GTP exchange factor isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.246.120","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.4770","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1050.80","properties":[{"key":"EntryName","value":"VPS9 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR041545","properties":[{"key":"EntryName","value":"DUF5601"}]},{"database":"InterPro","id":"IPR003123","properties":[{"key":"EntryName","value":"VPS9"}]},{"database":"InterPro","id":"IPR045046","properties":[{"key":"EntryName","value":"Vps9-like"}]},{"database":"InterPro","id":"IPR037191","properties":[{"key":"EntryName","value":"VPS9_dom_sf"}]},{"database":"InterPro","id":"IPR002653","properties":[{"key":"EntryName","value":"Znf_A20"}]},{"database":"PANTHER","id":"PTHR23101","properties":[{"key":"EntryName","value":"RAB GDP/GTP EXCHANGE FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23101:SF126","properties":[{"key":"EntryName","value":"RAB5 GDP_GTP EXCHANGE FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18151","properties":[{"key":"EntryName","value":"DUF5601"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02204","properties":[{"key":"EntryName","value":"VPS9"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01754","properties":[{"key":"EntryName","value":"zf-A20"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00167","properties":[{"key":"EntryName","value":"VPS9"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00259","properties":[{"key":"EntryName","value":"ZnF_A20"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57716","properties":[{"key":"EntryName","value":"Glucocorticoid receptor-like (DNA-binding domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF109993","properties":[{"key":"EntryName","value":"VPS9 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51205","properties":[{"key":"EntryName","value":"VPS9"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51036","properties":[{"key":"EntryName","value":"ZF_A20"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSLKSERRGIHVDQSELLCKKGCGYYGNPAWQGFCSKCWREEYHKARQKQIQEDWELAERLQREEEEAFASSQSSQGAQSLTFSKFEEKKTNEKTRKVTTVKKFFSASSRVGAKKAEIQEAKAPSPSINRQTSIETDRVSKEFIEFLKTFHKTGQEIYKQTKLFLEAMHYKRDLSIEEQSECTQDFYQNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLAIQKRIRALHWVTPQMLCVPVNEEIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQESENWSPDACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAKEVQDIVEKYPLEIRPPNQSVAAIDSENVENDKLPPPLQPQVYAG","length":492,"molWeight":57009,"crc64":"98828A4344B15EE7","md5":"D9AFF2FF866D603BF567A9A57EF3F555"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"PTM":1},"countByFeatureType":{"Chain":1,"Domain":1,"Zinc finger":1,"Region":3,"Coiled coil":1,"Compositional bias":1,"Binding site":4,"Modified residue":8,"Mutagenesis":4,"Beta strand":1,"Helix":2},"uniParcId":"UPI0000086802"}}