{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O15294","secondaryAccessions":["Q7Z3K0","Q8WWM8","Q96CC1","Q9UG57"],"uniProtkbId":"OGT1_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-06-21","entryVersion":251,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21240259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285374"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30699359"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37541260"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26369908"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26678539"}],"value":"2.4.1.255"}]},"alternativeNames":[{"fullName":{"value":"O-GlcNAc transferase subunit p110"}},{"fullName":{"value":"O-linked N-acetylglucosamine transferase 110 kDa subunit"},"shortNames":[{"value":"OGT"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11773972"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:8127"}],"value":"OGT"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P56558"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CGY8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12150998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19451179"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20018852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20018868"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20200153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21240259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285374"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22121020"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22923583"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23103939"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23353889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24474760"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24563466"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26237509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26369908"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27527864"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28302723"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28584052"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30699359"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34074792"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34667079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37541260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37962578"}],"value":"Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:12150998, PubMed:15361863, PubMed:19451179, PubMed:20018868, PubMed:21240259, PubMed:21285374, PubMed:23103939, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27713473, PubMed:37541260, PubMed:37962578). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 (PubMed:19451179, PubMed:20200153, PubMed:21285374, PubMed:22923583, PubMed:23353889, PubMed:24474760, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27527864, PubMed:30699359, PubMed:34074792, PubMed:34667079, PubMed:37541260, PubMed:37962578). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (PubMed:26678539). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28302723, PubMed:28584052). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B (PubMed:27527864). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (PubMed:30699359, PubMed:37541260)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20824293"}],"value":"The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527085"}],"value":"Has N-acetylglucosaminyltransferase activity: glycosylates proteins, such as HNRNPU, NEUROD1, NUP62 and PDCD6IP (PubMed:31527085). Displays specific substrate selectivity compared to other isoforms (PubMed:31527085)"}],"commentType":"FUNCTION","molecule":"Isoform 4"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48904"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:12251"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:57705"},{"database":"ChEBI","id":"CHEBI:58223"},{"database":"ChEBI","id":"CHEBI:90838"}],"ecNumber":"2.4.1.255","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21240259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285374"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23103939"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24563466"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26237509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27713473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30699359"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34074792"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26369908"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26678539"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48905"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24563466"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26237509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27713473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30699359"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34074792"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48908"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:12252"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:57705"},{"database":"ChEBI","id":"CHEBI:58223"},{"database":"ChEBI","id":"CHEBI:90840"}],"ecNumber":"2.4.1.255","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21240259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285374"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24563466"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26237509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37541260"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26678539"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48909"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24563466"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26237509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27713473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37541260"}]}]},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 4","reaction":{"name":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48904"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:12251"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:57705"},{"database":"ChEBI","id":"CHEBI:58223"},{"database":"ChEBI","id":"CHEBI:90838"}],"ecNumber":"2.4.1.255","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527085"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48905"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527085"}]}]},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 4","reaction":{"name":"L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48908"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:12252"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:57705"},{"database":"ChEBI","id":"CHEBI:58223"},{"database":"ChEBI","id":"CHEBI:90840"}],"ecNumber":"2.4.1.255","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527085"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48909"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527085"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21240259"}],"value":"Subject to product inhibition by UDP"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":1.8,"unit":"uM","substrate":"UDP-N-acetyl-D-glucosamine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21240259"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21240259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285374"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23103939"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27713473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527085"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37541260"}],"value":"Protein modification; protein glycosylation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P56558"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CGY8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12150998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20018852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20200153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21240259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23222540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23353889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23629655"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24995978"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34667079"}],"value":"Monomer; may exist in different oligomerization states in cells (PubMed:21240259, PubMed:27713473). Homotrimer, oligomerizes via TPR repeats 6 and 7. Trimerization is not necessary for activity in vitro, however it increases affinity for UDP-GlcNAc (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex (PubMed:12670868, PubMed:20200153). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852). Found in a complex with KIF5B, RHOT1, RHOT2 and TRAK1 (PubMed:24995978). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Component of a complex composed of KMT2E/MLL5 (isoform 3), OGT (isoform 1) and USP7; the complex stabilizes KMT2E/MLL5, preventing KMT2E/MLL5 ubiquitination and proteasomal-mediated degradation (PubMed:23629655, PubMed:26678539). Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase (PubMed:12150998). Interacts (via TPR 5-6) with TET1, TET2 and TET3 (PubMed:23222540, PubMed:23353889). Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Interacts with NSD2 (By similarity). Interacts with PROSER1; this interaction mediates TET2 O-GlcNAcylation and stability by promoting the interaction between OGT and TET2 (PubMed:34667079)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"}],"value":"Interacts with USP7"}],"commentType":"SUBUNIT","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28742148"}],"value":"(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein Tax; this interaction increases Tax interacting partner CREB1 O-GlcNAcylation"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"Q9BTC0","geneName":"DIDO1","intActId":"EBI-739985"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"P51610","geneName":"HCFC1","intActId":"EBI-396176"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"O95644","geneName":"NFATC1","intActId":"EBI-6907210"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"Q9H1M0","geneName":"NUP62CL","intActId":"EBI-751933"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"Q8NDX5","geneName":"PHC3","intActId":"EBI-1223801"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"P36873","geneName":"PPP1CC","intActId":"EBI-356283"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"P11464","geneName":"PSG1","intActId":"EBI-716740"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"Q04206","geneName":"RELA","intActId":"EBI-73886"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"O95721","geneName":"SNAP29","intActId":"EBI-490676"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"Q15750","geneName":"TAB1","intActId":"EBI-358643"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"E7EQS8","geneName":"TET2","intActId":"EBI-10177000"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"Q6N021","geneName":"TET2","intActId":"EBI-310727"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"Q6N021-1","geneName":"TET2","intActId":"EBI-20717492"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"O43151","geneName":"TET3","intActId":"EBI-2831148"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"Q9UPV9","geneName":"TRAK1","intActId":"EBI-1105048"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"O94763","geneName":"URI1","intActId":"EBI-357067"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"O94763-1","geneName":"URI1","intActId":"EBI-12590720"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"P09022","geneName":"Hoxa1","intActId":"EBI-3957603"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"P63088","geneName":"Ppp1cc","intActId":"EBI-80049"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O15294","intActId":"EBI-539828"},"interactantTwo":{"uniProtKBAccession":"Q8BG87","geneName":"Tet3","intActId":"EBI-9031997"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O15294-3","intActId":"EBI-11536584"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z5B5","geneName":"NUP62CL","intActId":"EBI-16439000"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294-3","intActId":"EBI-11536584"},"interactantTwo":{"uniProtKBAccession":"Q9H1M0","geneName":"NUP62CL","intActId":"EBI-751933"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294-3","intActId":"EBI-11536584"},"interactantTwo":{"uniProtKBAccession":"Q9UHR5","geneName":"SAP30BP","intActId":"EBI-751683"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294-3","intActId":"EBI-11536584"},"interactantTwo":{"uniProtKBAccession":"Q8N9R8","geneName":"SCAI","intActId":"EBI-4395514"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15294-3","intActId":"EBI-11536584"},"interactantTwo":{"uniProtKBAccession":"Q15973","geneName":"ZNF124","intActId":"EBI-2555767"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27713473"}],"value":"Predominantly localizes to the nucleus (PubMed:26678539). Translocates into the nucleus via association with importin KPNA1 (PubMed:27713473)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27713473"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27713473"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20824293"}],"value":"Associates with the mitochondrial inner membrane"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20824293"}],"value":"Mitochondrion","id":"SL-0173"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20824293"}],"value":"Membrane","id":"SL-0162"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 3","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P56558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285374"}],"value":"Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1 (PubMed:21285374). After insulin induction, translocated from the nucleus to the cell membrane via phosphatidylinositide binding. Colocalizes with AKT1 at the plasma membrane. TRAK1 recruits this protein to mitochondria. 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