{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O15244","secondaryAccessions":["Q5T7Q6","Q6PIQ8","Q8NG62","Q9NQB9"],"uniProtkbId":"S22A2_HUMAN","entryAudit":{"firstPublicDate":"2008-02-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-11-30","entryVersion":200,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12538837"}],"value":"Solute carrier family 22 member 2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9260930"}],"value":"Organic cation transporter 2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9260930"}],"value":"hOCT2"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:10966"}],"value":"SLC22A2"},"synonyms":[{"value":"OCT2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9R0W2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11907186"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12089365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12395288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15212162"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15783073"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15817714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16394027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17072098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24961373"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35307651"}],"value":"Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9260930, PubMed:9687576). Functions as a Na(+)-independent, bidirectional uniporter (PubMed:21128598, PubMed:9687576). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:15212162, PubMed:9260930, PubMed:9687576). However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (PubMed:15783073). Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters (PubMed:16581093, PubMed:17460754, PubMed:9687576). Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system (PubMed:17460754). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN) (PubMed:12089365, PubMed:15212162, PubMed:17072098, PubMed:24961373, PubMed:9260930). Mediates the uptake and efflux of choline (PubMed:9260930). Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine (PubMed:12538837, PubMed:21128598). Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (PubMed:11907186). Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:12395288, PubMed:16394027). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12089365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15212162"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16272756"}],"value":"In contrast with isoform 1, not able to transport guanidine, creatinine, cimetidine and metformin"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(R)-noradrenaline(out) = (R)-noradrenaline(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73871"},{"database":"ChEBI","id":"CHEBI:72587"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(R)-adrenaline(out) = (R)-adrenaline(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73875"},{"database":"ChEBI","id":"CHEBI:71406"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"serotonin(out) = serotonin(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73867"},{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dopamine(out) = dopamine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73863"},{"database":"ChEBI","id":"CHEBI:59905"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"histamine(out) = histamine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73879"},{"database":"ChEBI","id":"CHEBI:58432"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"thiamine(in) = thiamine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34919"},{"database":"ChEBI","id":"CHEBI:18385"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24961373"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"creatinine(in) = creatinine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74539"},{"database":"ChEBI","id":"CHEBI:16737"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15212162"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17072098"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-methylnicotinamide(out) = 1-methylnicotinamide(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73859"},{"database":"ChEBI","id":"CHEBI:16797"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"guanidine(out) = guanidine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73883"},{"database":"ChEBI","id":"CHEBI:30087"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12089365"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"choline(out) = choline(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:32751"},{"database":"ChEBI","id":"CHEBI:15354"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40972734"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"agmatine(out) = agmatine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72131"},{"database":"ChEBI","id":"CHEBI:58145"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:72132"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21128598"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:72133"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21128598"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"putrescine(out) = putrescine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72135"},{"database":"ChEBI","id":"CHEBI:326268"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"spermidine(in) = spermidine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:35039"},{"database":"ChEBI","id":"CHEBI:57834"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O70577"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tyramine(in) = tyramine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74783"},{"database":"ChEBI","id":"CHEBI:327995"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74787"},{"database":"ChEBI","id":"CHEBI:90039"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(R)-salsolinol(in) = (R)-salsolinol(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74791"},{"database":"ChEBI","id":"CHEBI:194082"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-methyl-(R)-salsolinol(in) = N-methyl-(R)-salsolinol(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74795"},{"database":"ChEBI","id":"CHEBI:194083"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"acetylcholine(in) = acetylcholine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74663"},{"database":"ChEBI","id":"CHEBI:15355"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15817714"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin F2alpha(out) = prostaglandin F2alpha(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50988"},{"database":"ChEBI","id":"CHEBI:57404"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11907186"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E2(out) = prostaglandin E2(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50984"},{"database":"ChEBI","id":"CHEBI:606564"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11907186"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12395288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26979622"}],"value":"Tyrosine phosphorylation of the transporter leads to activation of the transport activity (PubMed:26979622). TEA uptake is activated by tyrosine phosphorylation (PubMed:26979622). Inhibited by cGMP, most likely through a cGMP-binding protein that interacts with OCT2 (PubMed:12395288)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":3.0,"unit":"nmol/min/mg","enzyme":"enzyme for cyclo(his-pro) uptake","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"}]},{"velocity":2.7,"unit":"nmol/min/mg","enzyme":"enzyme for salsolinol uptake","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"}]},{"velocity":4.56,"unit":"nmol/min/mg","enzyme":"enzyme for thiamine uptake","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24961373"}]},{"velocity":23.5,"unit":"nmol/min/mg","enzyme":"enzyme for creatinine uptake","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":24.1,"unit":"nmol/min/mg","enzyme":"enzyme for agmatine uptake (at pH 6.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":11.5,"unit":"nmol/min/mg","enzyme":"enzyme for agmatine uptake (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538837"}]},{"velocity":12.9,"unit":"nmol/min/mg","enzyme":"enzyme for agmatine uptake (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":13.9,"unit":"nmol/min/mg","enzyme":"enzyme for agmatine uptake (at pH 8.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":16.0,"unit":"nmol/min/mg","enzyme":"enzyme for agmatine uptake (at pH 9.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":24.9,"unit":"nmol/min/mg","enzyme":"enzyme for putrescine uptake (at pH 6.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":15.6,"unit":"nmol/min/mg","enzyme":"enzyme for putrescine uptake (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":38.9,"unit":"nmol/min/mg","enzyme":"enzyme for putrescine uptake (at pH 8.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":52.3,"unit":"nmol/min/mg","enzyme":"enzyme for putrescine uptake (at pH 9.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":265.339,"unit":"nmol/min/mg","enzyme":"enzyme for choline uptake","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40972734"}]}],"michaelisConstants":[{"constant":74.0,"unit":"uM","substrate":"cyclo(his-pro)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"}]},{"constant":80.0,"unit":"uM","substrate":"serotonin","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"}]},{"constant":290.0,"unit":"uM","substrate":"serotonin","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"}]},{"constant":130.0,"unit":"uM","substrate":"salsolinol","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"}]},{"constant":150.0,"unit":"uM","substrate":"acetylcholine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15817714"}]},{"constant":210.0,"unit":"uM","substrate":"choline","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"}]},{"constant":26536.0,"unit":"uM","substrate":"choline","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40972734"}]},{"constant":300.0,"unit":"uM","substrate":"NMN","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"}]},{"constant":390.0,"unit":"uM","substrate":"dopamine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"}]},{"constant":420.0,"unit":"uM","substrate":"adrenaline","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"}]},{"constant":750.0,"unit":"uM","substrate":"thiamine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24961373"}]},{"constant":940.0,"unit":"uM","substrate":"histamine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"}]},{"constant":1300.0,"unit":"uM","substrate":"histamine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"}]},{"constant":1400.0,"unit":"uM","substrate":"dopamine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"}]},{"constant":1500.0,"unit":"uM","substrate":"noradrenaline","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"}]},{"constant":1900.0,"unit":"uM","substrate":"noradrenaline","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"}]},{"constant":4000.0,"unit":"uM","substrate":"creatinine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15212162"}]},{"constant":19010.0,"unit":"uM","substrate":"agmatine (at pH 6.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"constant":1400.0,"unit":"uM","substrate":"agmatine (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538837"}]},{"constant":1840.0,"unit":"uM","substrate":"agmatine (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"constant":740.0,"unit":"uM","substrate":"agmatine (at pH 8.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"constant":390.0,"unit":"uM","substrate":"agmatine (at pH 9.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"constant":33450.0,"unit":"uM","substrate":"putrescine (at pH 6.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"constant":11290.0,"unit":"uM","substrate":"putrescine (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"constant":3600.0,"unit":"uM","substrate":"putrescine (at pH 8.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"constant":1410.0,"unit":"uM","substrate":"putrescine (at pH 9.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"constant":0.0289,"unit":"uM","substrate":"prostaglandin E2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11907186"}]},{"constant":0.334,"unit":"uM","substrate":"prostaglandin F2-alpha","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11907186"}]},{"constant":19.0,"unit":"uM","substrate":"MPP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"}]},{"constant":24.0,"unit":"uM","substrate":"ASP (at 8 degrees Celsius)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16394027"}]}]},"phDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}],"value":"Optimum pH is 9 for agmatine and putrescine uptake."}]}},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11912245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15817714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35307651"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"}],"value":"Localized to the basal membrane of Sertoli cells (PubMed:35307651). Localized to the basolateral membrane of proximal tubule (PubMed:11912245). Localized to the luminal/apical membrane of distal tubule (PubMed:9260930). Localized to the luminal/apical membrane of ciliated epithelial cells in bronchi (PubMed:15817714)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9R0W2"}],"value":"Basolateral cell membrane","id":"SL-0026"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35307651"}],"value":"Basal cell membrane","id":"SL-0024"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15817714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"}],"value":"Apical cell membrane","id":"SL-0015"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["O15244-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"OCT2-A"}],"isoformIds":["O15244-2"],"sequenceIds":["VSP_031773","VSP_031774"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["O15244-3"],"sequenceIds":["VSP_031771","VSP_031772"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11912245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12089365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15817714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17393420"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460754"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35307651"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"}],"value":"Mainly expressed in kidney, in the cortex and medulla (PubMed:11912245, PubMed:12089365, PubMed:9260930). Localized in testis, mostly to peritubular myoid cells and Leydig cells and also detected along the basal membrane of Sertoli cells (PubMed:12089365, PubMed:35307651). Expressed in brain, in neurons of the cerebral cortex and in various subcortical nuclei (PubMed:12089365, PubMed:9260930, PubMed:9687576). In the brain, also detected in the dopaminergic regions of the substantia nigra (PubMed:17460754). Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract (PubMed:15817714). Also detected in secretory phase endometrium, in scattered stromal cells (PubMed:17393420). Expressed in spleen, placenta, small intestine and spinal cord (PubMed:12089365, PubMed:9260930). Weakly expressed in prostate, uterus and lung (PubMed:12089365)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12089365"}],"value":"Mainly expressed in kidney, bone marrow and testis (PubMed:12089365). Expressed in colon, skeletal muscle, spinal cord, placenta and liver (PubMed:12089365)"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16314463"}],"value":"May be down-regulated in diabetic patients"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26979622"}],"value":"Contains one proline-rich sequence (Pro-Glu-Ser-Pro-Arg) that may be involved in tyrosine-protein kinase YES1 binding and is required for the activation of substrate transport"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26979622"}],"value":"Tyrosine phosphorylated by tyrosine-protein kinase YES1"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9R0W2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12089365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15496291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15783073"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16006492"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16272756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16314463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16394027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16581093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16914559"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16951202"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24961373"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9687576"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12089365"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16272756"}],"value":"Mediates the renal secretion of many clinically used cationic drugs (PubMed:12089365, PubMed:16272756). Transports drugs such as diabetes treatment medicine metformin, 1-methyl-4-phenylpyridinium (MPP(+)), famotidine, ranitidine, amantadine, acriflavine, amiloride, memantine, cimetidine, platinum-based drugs cisplatin and oxaliplatin, 3'-azido-3'-deoxythymidine (AZT) and tetraethylammonium (TEA) (PubMed:12089365, PubMed:15496291, PubMed:15783073, PubMed:16006492, PubMed:16272756, PubMed:16314463, PubMed:16394027, PubMed:16581093, PubMed:16914559, PubMed:16951202, PubMed:24961373, PubMed:9260930). Mediates the bidirectional transport of MPP(+) (PubMed:12089365, PubMed:9260930, PubMed:9687576). Metformin competitively inhibits OCT1-mediated thiamine uptake, leading to a decrease in hepatic steatosis (PubMed:24961373). Plays a predominant role in the anticancer activity of cisplatin and oxaliplatin and may contribute to antitumor specificity (PubMed:16914559, PubMed:16951202). Involved in cisplatin-induced nephrotoxicity (By similarity)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11912245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9260930"}],"value":"Most authors have deduced a localization at the basolateral membrane of proximal tubules (PubMed:11912245). 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